Yoshihito Yokoyama


Affiliation: Hirosaki University School of Medicine
Country: Japan


  1. Matsumura Y, Yokoyama Y, Hirakawa H, Shigeto T, Futagami M, Mizunuma H. The prophylactic effects of a traditional Japanese medicine, goshajinkigan, on paclitaxel-induced peripheral neuropathy and its mechanism of action. Mol Pain. 2014;10:61 pubmed publisher
    ..These results showed that PTX induced hyperalgesia by enhancing TRPV4 expression, and suggested that GJG might alleviate hyperalgesia by preventing degeneration of the ganglion cells and suppressing TRPV4 expression. ..
  2. Futagami M, Yokoyama Y, Iino K, Aoki M, Shoji T, Sugiyama T, et al. Investigation of the clinicopathological features of squamous cell carcinoma of the vulva: a retrospective survey of the Tohoku Gynecologic Cancer Unit. Int J Clin Oncol. 2015;20:1005-11 pubmed publisher
    ..001). Although many patients had advanced-stage disease in the CCRT group, the therapeutic outcome for the surgery and CCRT groups was similar. Thus, CCRT may be a promising treatment for squamous cell carcinoma of the vulva. ..
  3. Tamura R, Yokoyama Y, Yoshida H, Imaizumi T, Mizunuma H. 4-Methylumbelliferone inhibits ovarian cancer growth by suppressing thymidine phosphorylase expression. J Ovarian Res. 2014;7:94 pubmed publisher
    ..These results suggest that 4-MU exerts its antitumor effect on ovarian cancer through suppressing TP expression. ..
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    Yokoyama Y, Charnock Jones D, Licence D, Yanaihara A, Hastings J, Holland C, et al. Expression of vascular endothelial growth factor (VEGF)-D and its receptor, VEGF receptor 3, as a prognostic factor in endometrial carcinoma. Clin Cancer Res. 2003;9:1361-9 pubmed
    ..In addition, VEGF-D and VEGFR-3 may be promising targets for new therapeutic strategies in endometrial carcinoma. ..
  5. Yokoyama Y, Charnock Jones D, Licence D, Yanaihara A, Hastings J, Holland C, et al. Vascular endothelial growth factor-D is an independent prognostic factor in epithelial ovarian carcinoma. Br J Cancer. 2003;88:237-44 pubmed
    ..Since VEGF-D was found to be an independent predictor of poor outcome, its measurement, together with other prognostic markers may improve prospective identification of patients with a poor prognosis. ..
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    Yokoyama Y, Ono Y, Sakamoto T, Fukuda I, Mizunuma H. Asymptomatic intracardiac metastasis from a low-grade endometrial stromal sarcoma with successful surgical resection. Gynecol Oncol. 2004;92:999-1001 pubmed
    ..A case of a patient who successfully underwent surgical extraction of metastatic tumors of the low-grade ESS in the right ventricle is described in the present report...
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    Yokoyama Y, Xin B, Shigeto T, Umemoto M, Kasai Sakamoto A, Futagami M, et al. Clofibric acid, a peroxisome proliferator-activated receptor alpha ligand, inhibits growth of human ovarian cancer. Mol Cancer Ther. 2007;6:1379-86 pubmed
    ..We conclude that CA could be an effective agent in ovarian cancer and should be tested alone and in combination with other anticancer drugs...
  8. Yokoyama Y, Xin B, Shigeto T, Mizunuma H. Combination of ciglitazone, a peroxisome proliferator-activated receptor gamma ligand, and cisplatin enhances the inhibition of growth of human ovarian cancers. J Cancer Res Clin Oncol. 2011;137:1219-28 pubmed publisher
    ..In this study, we investigated the effects of combination of ciglitazone, a PPAR? ligand, and cisplatin, a cytotoxic anti-cancer drug, on growth of ovarian cancer...
  9. Yokoyama Y, Hirakawa H, Wang H, Mizunuma H. Is omentectomy mandatory in the operation for ovarian cancer? Preliminary results in a rat study. Eur J Obstet Gynecol Reprod Biol. 2012;164:89-92 pubmed publisher
    ..Therefore, although omentectomy is rewarding if disseminated foci are present in the omentum, it is suggested that the timing of omentectomy requires reconsideration in the absence of omental metastasis. ..

More Information


  1. Yokoyama Y, Futagami M, Fujimoto T, Terada Y, Takatori E, Sugiyama T, et al. Investigation of the clinicopathological features of fallopian tube malignancy. Oncol Rep. 2013;30:79-84 pubmed publisher
    ..These results suggest that since FTM frequently results in solitary recurrence, aggressive recurrence treatment including SDS could improve prognosis...
  2. Matsushita Y, Yokoyama Y, Yoshida H, Osawa Y, Mizunuma M, Shigeto T, et al. The level of RECQL1 expression is a prognostic factor for epithelial ovarian cancer. J Ovarian Res. 2014;7:107 pubmed publisher
    ..These results suggest that RECQL1 is a prognostic factor for EOC and that RECQL1 contributes to potential malignancy by inhibiting apoptosis. ..