Norio Yasui-Furukori

Summary

Affiliation: Hirosaki University School of Medicine
Country: Japan

Publications

  1. pmc Worsened hypertension control induced by aripiprazole
    Norio Yasui-Furukori
    Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan
    Neuropsychiatr Dis Treat 9:505-7. 2013
  2. pmc Differential effects of the catechol-O-methyltransferase Val158Met genotype on the cognitive function of schizophrenia patients and healthy Japanese individuals
    Shoko Tsuchimine
    Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan
    PLoS ONE 8:e76763. 2013
  3. pmc Lithium in tap water and suicide mortality in Japan
    Norio Sugawara
    Department of Neuropsychiatry, Hirosaki University School of Medicine, 5 Zaifucho, Hirosaki, Aomori 036 8562, Japan
    Int J Environ Res Public Health 10:6044-8. 2013
  4. pmc Interaction between paliperidone extended release and TS-1(®), an oral anticancer drug containing a 5-fluorouracil derivative, in a schizophrenic patient
    Norio Yasui-Furukori
    Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan
    Neuropsychiatr Dis Treat 9:317-9. 2013
  5. ncbi request reprint Association between plasma brain-derived neurotrophic factor levels and personality traits in healthy Japanese subjects
    Norio Yasui-Furukori
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan Electronic address
    Psychiatry Res 210:220-3. 2013
  6. pmc Body mass index and quality of life among outpatients with schizophrenia in Japan
    Norio Sugawara
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, Japan
    BMC Psychiatry 13:108. 2013
  7. pmc Body composition in patients with schizophrenia: Comparison with healthy controls
    Norio Sugawara
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, Japan
    Ann Gen Psychiatry 11:11. 2012
  8. doi request reprint The efficacy of low-dose aripiprazole treatment for trichotillomania
    Norio Yasui-Furukori
    Department of Neuropsychiatry Graduate School of Medicine, Hirosaki University, Hirosaki, Japan
    Clin Neuropharmacol 34:258-9. 2011
  9. doi request reprint Effect of adjunctive treatment with aripiprazole to atypical antipsychotics on cognitive function in schizophrenia patients
    Norio Yasui-Furukori
    Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan
    J Psychopharmacol 26:806-12. 2012
  10. pmc Update on the development of lurasidone as a treatment for patients with acute schizophrenia
    Norio Yasui-Furukori
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Aomori, Japan
    Drug Des Devel Ther 6:107-15. 2012

Collaborators

Detail Information

Publications87

  1. pmc Worsened hypertension control induced by aripiprazole
    Norio Yasui-Furukori
    Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan
    Neuropsychiatr Dis Treat 9:505-7. 2013
    ..The hypertensive state of these patients recovered after switching back to other antipsychotics, and these cases suggest that aripiprazole may lead to hypertension...
  2. pmc Differential effects of the catechol-O-methyltransferase Val158Met genotype on the cognitive function of schizophrenia patients and healthy Japanese individuals
    Shoko Tsuchimine
    Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan
    PLoS ONE 8:e76763. 2013
    ..We investigated whether the COMT Val158Met genotype was associated with cognitive function in 149 healthy controls and 118 patients with schizophrenia...
  3. pmc Lithium in tap water and suicide mortality in Japan
    Norio Sugawara
    Department of Neuropsychiatry, Hirosaki University School of Medicine, 5 Zaifucho, Hirosaki, Aomori 036 8562, Japan
    Int J Environ Res Public Health 10:6044-8. 2013
    ..These findings indicate that natural levels of lithium in drinking water might have a protective effect on the risk of suicide among females. Future research is warranted to confirm this association. ..
  4. pmc Interaction between paliperidone extended release and TS-1(®), an oral anticancer drug containing a 5-fluorouracil derivative, in a schizophrenic patient
    Norio Yasui-Furukori
    Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan
    Neuropsychiatr Dis Treat 9:317-9. 2013
    ..This case suggests there is drug interaction between paliperidone extended-release tablets and TS-1...
  5. ncbi request reprint Association between plasma brain-derived neurotrophic factor levels and personality traits in healthy Japanese subjects
    Norio Yasui-Furukori
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan Electronic address
    Psychiatry Res 210:220-3. 2013
    ..177, p=0.018) and self-directedness scores (r=0.165, p=0.028). Our findings suggest that plasma BDNF levels are associated with depression-related personality traits...
  6. pmc Body mass index and quality of life among outpatients with schizophrenia in Japan
    Norio Sugawara
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, Japan
    BMC Psychiatry 13:108. 2013
    ..This investigation evaluated the relationship between body weight and the self-reported quality of life (QOL) of Japanese patients with schizophrenia...
  7. pmc Body composition in patients with schizophrenia: Comparison with healthy controls
    Norio Sugawara
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, Japan
    Ann Gen Psychiatry 11:11. 2012
    ..abstract:..
  8. doi request reprint The efficacy of low-dose aripiprazole treatment for trichotillomania
    Norio Yasui-Furukori
    Department of Neuropsychiatry Graduate School of Medicine, Hirosaki University, Hirosaki, Japan
    Clin Neuropharmacol 34:258-9. 2011
    ..After stopping treatment, 1.5 to 3.0 mg/d of aripiprazole alone improved TMM symptoms upon recurrence. These findings indicate that further investigation of low-dose aripiprazole for the treatment of TTM is warranted...
  9. doi request reprint Effect of adjunctive treatment with aripiprazole to atypical antipsychotics on cognitive function in schizophrenia patients
    Norio Yasui-Furukori
    Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan
    J Psychopharmacol 26:806-12. 2012
    ..These results suggest that adjunctive treatment with aripiprazole improves motor speed but worsens some cognitive functions. It is likely that these effects are due to the dopamine D2 antagonistic effect of aripiprazole...
  10. pmc Update on the development of lurasidone as a treatment for patients with acute schizophrenia
    Norio Yasui-Furukori
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Aomori, Japan
    Drug Des Devel Ther 6:107-15. 2012
    ..These sources have not been subjected to the peer review processes of medical journals; thus, the results presented in these forums may require further quality review and subsequent revision prior to final publication...
  11. pmc Effect of age and disease on bone mass in Japanese patients with schizophrenia
    Norio Sugawara
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, Japan
    Ann Gen Psychiatry 11:5. 2012
    ..abstract:..
  12. doi request reprint Paroxetine-associated hypereosinophilia may clinically resemble a panic attack
    Norio Yasui-Furukori
    Department of Neuropsychiatry, and Integrated Medical Education, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan
    Clin Neuropharmacol 35:47-8. 2012
    ..Because it is sometimes difficult to distinguish between psychiatric symptoms such as panic attack and eosinophilia-related symptoms, frequent hematologic examination is required for patients treated with paroxetine...
  13. pmc Hearing impairment and cognitive function among a community-dwelling population in Japan
    Norio Sugawara
    Department of Psychiatry, Hirosaki Aiseikai Hospital, Hirosaki, 036 8151, Japan
    Ann Gen Psychiatry 10:27. 2011
    ..abstract:..
  14. pmc Comparison of prevalence of metabolic syndrome in hospital and community-based Japanese patients with schizophrenia
    Norio Sugawara
    Department of Psychiatry, Hirosaki Aiseikai Hospital, Hirosaki, Japan
    Ann Gen Psychiatry 10:21. 2011
    ..abstract:..
  15. pmc Cognitive function among hemodialysis patients in Japan
    Gen Odagiri
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, Japan
    Ann Gen Psychiatry 10:20. 2011
    ..abstract:..
  16. ncbi request reprint Association between multidrug resistance 1 (MDR1) gene polymorphisms and therapeutic response to bromperidol in schizophrenic patients: a preliminary study
    Norio Yasui-Furukori
    Department of Neuropsychiatry, Hirosaki University, School of Medicine, Hirosaki, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:286-91. 2006
    ..The present results suggest that the C3435T polymorphism is associated with some therapeutic response to bromperidol in schizophrenic patients, possibly by different drug concentration in the brain...
  17. doi request reprint Association between dopamine-related polymorphisms and plasma concentrations of prolactin during risperidone treatment in schizophrenic patients
    Norio Yasui-Furukori
    Department of Neuropsychiatry, Hirosaki University School of Medicine, and Department of Psychiatry, Hirosaki Aiseikai Hospital, Hirosaki 036 8562, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1491-5. 2008
    ..These findings suggest that plasma prolactin concentrations in females are much higher than in males but the dopamine-related variants are not predominantly associated with plasma concentration of prolactin...
  18. doi request reprint Hallucination induced by paroxetine discontinuation in patients with major depressive disorders
    Norio Yasui-Furukori
    Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan
    Psychiatry Clin Neurosci 65:384-5. 2011
    ..These observations suggest that hallucinations are a part of the discontinuation syndrome that results from paroxetine discontinuation. Physicians should be aware of this symptom...
  19. ncbi request reprint Digitalis intoxication induced by paroxetine co-administration
    Norio Yasui-Furukori
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Lancet 367:788. 2006
  20. ncbi request reprint Effect of itraconazole on pharmacokinetics of paroxetine: the role of gut transporters
    Norio Yasui-Furukori
    Department of Neuropsychiatry Hirosaki University School of Medicine, Hirosaki, Japan
    Ther Drug Monit 29:45-8. 2007
    ..05), the alteration was small (1.1 fold). The present study demonstrated that the bioavailability of paroxetine was increased by itraconazole, suggesting a possible involvement of P-glycoprotein in the pharmacokinetics of paroxetine...
  21. ncbi request reprint Association between major Multidrug Resistance 1 (MDR1) gene polymorphisms and plasma concentration of prolactin during risperidone treatment in schizophrenic patients
    Norio Yasui-Furukori
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:1230-4. 2007
    ..These findings suggest that prolactin concentrations in females are much higher than in males but the major MDR1 variants are not associated with the plasma concentration of prolactin...
  22. ncbi request reprint [Clinical pharmacogenetics in the treatment of schizophrenia]
    Norio Furukori
    Department of Neuropsychiatry, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 30:65-9. 2010
    ..Clinical pharmacogenetical studies from both a phamacokinetical and a pharmacogynamical point of view are required in order to introduce and practice individualized medicine in the psychiatric field easily...
  23. ncbi request reprint Association between cytochrome P450 (CYP) 2C19 polymorphisms and harm avoidance in Japanese
    Norio Yasui-Furukori
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, Japan
    Am J Med Genet B Neuropsychiatr Genet 144:724-7. 2007
    ..350, n.s.), reward dependence (RD; F = 1.080, n.s.), or persistence (P; F = 0.786, n.s.) among CYP2C19 genotypes. This study demonstrated that a significant association between CYP2C19 activity and HA is present in Japanese...
  24. doi request reprint Prolactin fluctuation over the course of a day during treatments with three atypical antipsychotics in schizophrenic patients
    Norio Yasui-Furukori
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, Japan
    Hum Psychopharmacol 25:236-42. 2010
    ..The plasma concentration of prolactin during perospirone treatment therefore depends on the time of sampling...
  25. ncbi request reprint Terbinafine increases the plasma concentration of paroxetine after a single oral administration of paroxetine in healthy subjects
    Norio Yasui-Furukori
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Eur J Clin Pharmacol 63:51-6. 2007
    ..The aim of this study was to examine the effects of terbinafine, a potent inhibitor of CYP2D6, on pharmacokinetics of paroxetine...
  26. doi request reprint Gender-specific prolactin response to antipsychotic treatments with risperidone and olanzapine and its relationship to drug concentrations in patients with acutely exacerbated schizophrenia
    Norio Yasui-Furukori
    Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki 036 8562, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:537-40. 2010
    ..01). The present study suggests that the predominant factors influencing hyperprolactinemia are young female for risperidone treatment, and being female and lower drug concentration as a predictor for hyperprolactinemia under olanzapine...
  27. ncbi request reprint Different serum concentrations of steady-state valproic acid in two sustained-release formulations
    Norio Yasui-Furukori
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, Japan
    Psychiatry Clin Neurosci 61:308-12. 2007
    ..When a prescription for valproic acid is switched from one drug to the other, prescribers should be aware that the therapeutic drug monitoring data are not consistent...
  28. doi request reprint No association between polymorphism in tyrosine hydroxylase and personality traits in healthy Japanese subjects
    Shoko Tsuchimine
    Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan
    Psychiatry Clin Neurosci 64:196-8. 2010
    ..These findings suggest that the (TCAT)(n) repeat polymorphism in the TH gene does not contribute to the personality traits evaluated on the TCI in healthy Japanese subjects...
  29. ncbi request reprint Clinical response to risperidone in relation to plasma drug concentrations in acutely exacerbated schizophrenic patients
    N Yasui-Furukori
    Department of Neuropsychiatry, Hirosaki Graduate University, School of Medicine, Hirosaki 036 8562, Japan
    J Psychopharmacol 24:987-94. 2010
    ..These findings should be replicated with a larger patient sample...
  30. doi request reprint Dose-dependent effects of adjunctive treatment with aripiprazole on hyperprolactinemia induced by risperidone in female patients with schizophrenia
    Norio Yasui-Furukori
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, Japan
    J Clin Psychopharmacol 30:596-9. 2010
    ..The effect occurs even when a low dosage (3 mg/d) of aripiprazole was used and achieves a plateau at dosages beyond 6 mg/d...
  31. ncbi request reprint Glucose metabolism in Japanese schizophrenia patients treated with risperidone or olanzapine
    Norio Yasui-Furukori
    Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan
    J Clin Psychiatry 70:95-100. 2009
    ....
  32. ncbi request reprint Poor reliability of therapeutic drug monitoring data for haloperidol and bromperidol using enzyme immunoassay
    Norio Yasui-Furukori
    Department of Clinical Pharmacology, Hirosaki University School of Medicine, Hirosaki, Japan
    Ther Drug Monit 25:709-14. 2003
    ..Therefore, some limitation of TDM data of haloperidol and bromperidol using the EIA kits, ie, high precision but poor accuracy, should be kept in mind...
  33. ncbi request reprint Determination of donepezil, an acetylcholinesterase inhibitor, in human plasma by high-performance liquid chromatography with ultraviolet absorbance detection
    Norio Yasui-Furukori
    Department of Clinical Pharmacology, Hirosaki University School of Medicine, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 768:261-5. 2002
    ..The method shows good specificity with respect to commonly prescribed psychotropic drugs, and it could be successfully applied for pharmacokinetic studies and therapeutic drug monitoring...
  34. ncbi request reprint The characteristics of side-effects of bromperidol in schizophrenic patients
    Norio Yasui-Furukori
    Department of Clinical Pharmacology, Hirosaki University School of Medicine, Hirosaki, Japan
    Psychiatry Clin Neurosci 56:103-6. 2002
    ..These findings suggest that acute dystonia is affected by age factor, and that daily dosage or monitoring of drug concentration is unlikely to be a useful marker for the prediction of side-effects during bromperidol treatment...
  35. ncbi request reprint Comparison of prolactin concentrations between haloperidol and risperidone treatments in the same female patients with schizophrenia
    Norio Yasui-Furukori
    Department of Clinical Pharmacology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Psychopharmacology (Berl) 162:63-6. 2002
    ....
  36. doi request reprint No association between hormonal abnormality and sexual dysfunction in Japanese schizophrenia patients treated with antipsychotics
    Norio Yasui-Furukori
    Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan
    Hum Psychopharmacol 27:82-9. 2012
    ..Although sexual dysfunction is believed to be caused by hormonal abnormalities, few reports have studied sexual dysfunction and its association with hormonal abnormalities in Asian populations with schizophrenia...
  37. pmc Time effects of food intake on the pharmacokinetics and pharmacodynamics of quazepam
    Norio Yasui-Furukori
    Department of Clinical Pharmacology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Br J Clin Pharmacol 55:382-8. 2003
    ..There is little information on interaction between food and the hypnotic agent quazepam. We therefore studied the effects of food and its time interval on the pharmacokinetics and pharmacodynamics of quazepam...
  38. ncbi request reprint Fluvoxamine dose-dependent interaction with haloperidol and the effects on negative symptoms in schizophrenia
    Norio Yasui-Furukori
    Department of Clinical Pharmacology, Hirosaki University School of Medicine, 036 8562, Hirosaki, Japan
    Psychopharmacology (Berl) 171:223-7. 2004
    ..However, relatively small elevations in haloperidol concentration did not lead to the development of extrapyramidal symptoms under the conditions of this study...
  39. ncbi request reprint Significant dose effect of carbamazepine on reduction of steady-state plasma concentration of haloperidol in schizophrenic patients
    Norio Yasui-Furukori
    Department of Clinical Pharmacology, Hirosaki University School of Medicine, Hirosaki, Japan
    J Clin Psychopharmacol 23:435-40. 2003
    ....
  40. doi request reprint Inverse correlation between clinical response to paroxetine and plasma drug concentration in patients with major depressive disorders
    Norio Yasui-Furukori
    Department of Neuropsychiatry, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Hum Psychopharmacol 26:602-8. 2011
    ..There are few data concerning a clear relationship between the clinical effect of paroxetine and plasma drug concentrations, although therapeutic ranges have been established for some tricyclic antidepressants...
  41. pmc Effects of various factors on steady-state plasma concentrations of risperidone and 9-hydroxyrisperidone: lack of impact of MDR-1 genotypes
    Norio Yasui-Furukori
    Department of Clinical Pharmacology, Hirosaki University School of Medicine, Hirosaki, Japan
    Br J Clin Pharmacol 57:569-75. 2004
    ..An in vitro study has suggested that risperidone is a substrate of P-glycoprotein, which is coded by MDR-1 gene. Thus, we studied the effects of major polymorphisms of the MDR-1 gene on plasma drug concentrations...
  42. ncbi request reprint Simultaneous determination of haloperidol and bromperidol and their reduced metabolites by liquid-liquid extraction and automated column-switching high-performance liquid chromatography
    Norio Yasui-Furukori
    Department of Clinical Pharmacology, School of Medicine, Hirosaki University, Hirosaki 036 8562, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 805:175-80. 2004
    ....
  43. ncbi request reprint Establishment of new cloned enzyme donor immunoassays (CEDIA) for haloperidol and bromperidol
    Norio Yasui-Furukori
    Department of Clinical Pharmacology, Hirosaki University School of Medicine, Hirosaki, Japan
    Ther Drug Monit 26:336-41. 2004
    ..914, P < 0.001) concentrations. This study has, therefore, demonstrated that the CEDIA assay has a quick run time with high precision and accuracy, and this method is a useful tool for the TDM of haloperidol or bromperidol...
  44. ncbi request reprint Steady-state pharmacokinetics of a new antipsychotic agent perospirone and its active metabolite, and its relationship with prolactin response
    Norio Yasui-Furukori
    Department of Clinical Pharmacology, Hirosaki University School of Medicine, Hirosaki, Japan
    Ther Drug Monit 26:361-5. 2004
    ..The active metabolite hydroxyperospirone may play an important role in the antipsychotic effect because the plasma concentration of this metabolite is higher than that of the parent compound...
  45. doi request reprint Comparing the influence of dopamine D₂ polymorphisms and plasma drug concentrations on the clinical response to risperidone
    Norio Yasui-Furukori
    Department of Neuropsychiatry, Hirosaki Graduate University, School of Medicine, Hirosaki, Japan
    J Clin Psychopharmacol 31:633-7. 2011
    ..Both the genotyping of DRD2 and the monitoring of plasma drug concentrations may be useful for improving clinically dominant symptoms. Further work involving replication in a larger sample is required to support our findings...
  46. ncbi request reprint Sensitive determination of midazolam and 1'-hydroxymidazolam in plasma by liquid-liquid extraction and column-switching liquid chromatography with ultraviolet absorbance detection and its application for measuring CYP3A activity
    Norio Yasui-Furukori
    Department of Clinical Pharmacology, School of Medicine, Hirosaki University, 5 Zaifu, Hirosaki 036 8562, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 811:153-7. 2004
    ..This method was sensitive enough for pharmacokinetic studies measuring CYP3A activity in human volunteers following an intravenous (1 mg) and a single-oral administration (2 mg) of a subtherapeutic midazolam dose...
  47. ncbi request reprint Different effects of three transporting inhibitors, verapamil, cimetidine, and probenecid, on fexofenadine pharmacokinetics
    Norio Yasui-Furukori
    Department of Clinical Pharmacology, Hirosaki University Schoo of Medicine, Hirosaki 036 8502, Japan
    Clin Pharmacol Ther 77:17-23. 2005
    ..Fexofenadine is a substrate of P-glycoprotein and organic anion transporting polypeptides. The aim of this study was to compare the inhibitory effects of different transporting inhibitors on fexofenadine pharmacokinetics...
  48. ncbi request reprint Determination of fluvoxamine and its metabolite fluvoxamino acid by liquid-liquid extraction and column-switching high-performance liquid chromatography
    Norio Yasui-Furukori
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Zaifu cho 5, Hirosaki 0368562, Japan
    J Pharm Biomed Anal 37:121-5. 2005
    ..The limit of quantification was 1.2 and 0.9 ng/ml for fluvoxamine and fluvoxamino acid, respectively. This method shows successful application for pharmacokinetic studies and therapeutic drug monitoring...
  49. pmc Different inhibitory effect of fluvoxamine on omeprazole metabolism between CYP2C19 genotypes
    Norio Yasui-Furukori
    Department of Clinical Pharmacology, Hirosaki University, School of Medicine, Hirosaki, Japan
    Br J Clin Pharmacol 57:487-94. 2004
    ..The inhibitory effect of fluvoxamine, an inhibitor of CYP2C19 as well as CYP1A2, on the metabolism of omeprazole was compared between different genotypes for CYP2C19...
  50. ncbi request reprint Effect of verapamil on pharmacokinetics and pharmacodynamics of risperidone: in vivo evidence of involvement of P-glycoprotein in risperidone disposition
    Taku Nakagami
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Clin Pharmacol Ther 78:43-51. 2005
    ..A recent in vitro study has shown that risperidone is a substrate of P-glycoprotein. The aim of this study was to confirm the effects of verapamil, a P-glycoprotein inhibitor, on the pharmacokinetics of risperidone...
  51. ncbi request reprint Effects of CYP2D6 genotypes on plasma concentrations of risperidone and enantiomers of 9-hydroxyrisperidone in Japanese patients with schizophrenia
    Norio Yasui-Furukori
    Department of Clinical Pharmacology, Hirosaki University School of Medicine, Hirosaki, Japan
    J Clin Pharmacol 43:122-7. 2003
    ....
  52. pmc Effects of clarithromycin on lansoprazole pharmacokinetics between CYP2C19 genotypes
    Masato Saito
    First Department of Internal Medicine, Hirosaki University School of Medicine, Hirosako, Japan
    Br J Clin Pharmacol 59:302-9. 2005
    ..Lansoprazole is a substrate of CYP2C19 and CYP3A. The aim of this study was to compare the inhibitory effects of clarithromycin, an inhibitor of CYP3A on the metabolism of lansoprazole between CYP2C19 genotypes...
  53. ncbi request reprint Identification of the time-point which gives a plasma rabeprazole concentration that adequately reflects the area under the concentration-time curve
    Takenori Niioka
    Department of Pharmacy, Hirosaki University Hospital, Hirosaki, Japan
    Eur J Clin Pharmacol 62:855-61. 2006
    ..The purpose of this study is to evaluate whether a simple formula using limited blood samples can predict the area under the plasma rabeprazole concentration-time curve (AUC) in co-administration with CYP inhibitors...
  54. ncbi request reprint Absolute bioavailability and metabolism of omeprazole in relation to CYP2C19 genotypes following single intravenous and oral administrations
    Tsukasa Uno
    Department of Clinical Pharmacology, Hirosaki University School of Medicine, Hirosaki, Japan
    Eur J Clin Pharmacol 63:143-9. 2007
    ..The aim of this study was to evaluate the absolute bioavailability and the metabolism of omeprazole following single intravenous and oral administrations to healthy subjects in relation to CYP2C19 genotypes...
  55. ncbi request reprint Single oral dose pharmacokinetics of quazepam is influenced by CYP2C19 activity
    Takashi Fukasawa
    Department of Neuropsychiatry, Yamagata University School of Medicine, Yamagata, Japan
    Ther Drug Monit 26:529-33. 2004
    ..The present study suggests that the single oral dose pharmacokinetics of quazepam are influenced by CYP2C19 activity but not by cigarette smoking...
  56. ncbi request reprint Effects of fluvoxamine on lansoprazole pharmacokinetics in relation to CYP2C19 genotypes
    Norio Yasui-Furukori
    Department of Clinical Pharmacology, Hirosaki University, School of Medicine, Hirosaki 036 8562, Japan
    J Clin Pharmacol 44:1223-9. 2004
    ..The present study indicates that there are significant drug interactions between lansoprazole and fluvoxamine in EMs. CYP2C19 is predominantly involved in lansoprazole metabolism in EMs...
  57. pmc Different effects of fluvoxamine on rabeprazole pharmacokinetics in relation to CYP2C19 genotype status
    Tsukasa Uno
    Department of Clinical Pharmacology, Hirosaki University School of Medicine, Japan
    Br J Clin Pharmacol 61:309-14. 2006
    ..Our objective was to evaluate the possible effect of an inhibitor of CYP2C19, fluvoxamine, and compare the inhibitory effect of fluvoxamine on the metabolism of rabeprazole between CYP2C19 genotypes...
  58. ncbi request reprint Effects of clarithromycin and verapamil on rabeprazole pharmacokinetics between CYP2C19 genotypes
    Mikiko Shimizu
    Department of Clinical Pharmacology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Eur J Clin Pharmacol 62:597-603. 2006
    ..The aim of this study was to compare possible effects of clarithromycin and verapamil as inhibitors of CYP3A4 on the pharmacokinetics of rabeprazole among CYP2C19 genotypes...
  59. ncbi request reprint Identification of a single time-point for plasma lansoprazole measurement that adequately reflects area under the concentration-time curve
    Takenori Niioka
    Department of Pharmacy, Hirosaki University School of Medicine, Hirosaki, Japan
    Ther Drug Monit 28:321-5. 2006
    ..This method of plasma concentration monitoring at one time-point might be more suitable for AUC estimation than reference to CYP2C19 genotypes, particularly in coadministration of CYP mediators...
  60. ncbi request reprint Dopamine D2 receptor gene polymorphisms predict well the response to dopamine antagonists at therapeutic dosages in patients with schizophrenia
    Noboru Sakumoto
    Department of Neuropsychiatry, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    Psychiatry Clin Neurosci 61:174-80. 2007
    ....
  61. ncbi request reprint Effects of various CYP2D6 genotypes on the steady-state plasma concentrations of risperidone and its active metabolite, 9-hydroxyrisperidone, in Japanese patients with schizophrenia
    Kazuo Mihara
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, Japan
    Ther Drug Monit 25:287-93. 2003
    ..However, similar active moiety of risperidone among different genotype groups suggests that the determination of the CYP2D6 genotype has little importance for clinical situations...
  62. doi request reprint Association between monoamine oxidase A (MAOA) and personality traits in Japanese individuals
    Shoko Tsuchimine
    Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, 036 8562 Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1932-5. 2008
    ..There were no differences between other scores of TCI subscales and MAOA-VNTR polymorphism. Our results suggest a gender-specific contribution of MAOA-VNTR polymorphism to persistence scores...
  63. doi request reprint Ankle brachial pressure index as a marker of apathy in a community-dwelling population
    Norio Sugawara
    Department of Psychiatry, Hirosaki Aiseikai Hospital, Hirosaki, Japan
    Int J Geriatr Psychiatry 26:409-14. 2011
    ..Several studies have shown the relationship between apathy and atherosclerotic change in poststroke patients. Although apathy is confused with depression, it might be a specific neuropsychiatric syndrome separate from depression...
  64. ncbi request reprint Significant pharmacokinetic interaction between risperidone and carbamazepine: its relationship with CYP2D6 genotypes
    Shingo Ono
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Psychopharmacology (Berl) 162:50-4. 2002
    ..The present study suggests that carbamazepine induces the metabolism of risperidone and 9-hydroxyrisperidone, and that the decrease in risperidone concentration is dependent on the CYP2D6 activity...
  65. ncbi request reprint Effect of dietary fat content in meals on pharmacokinetics of quazepam
    Norio Yasui-Furukori
    Department of Clinical Pharmacology, Hirosaki University School of Medicine, Hirosaki, Japan
    J Clin Pharmacol 42:1335-40. 2002
    ..5-fold for Cmax and 2.1-fold for AUC(0-8), on average). It might not be necessary to do dose adjustment with meal content because quazepam is well tolerated...
  66. doi request reprint Effect of dose timing in relation to food intake on systemic exposure to blonanserin
    Junji Saruwatari
    Department of Neuropsychiatry, Hirosaki University School of Medicine, 5 Zaifucho, Hirosaki 036 8562, Japan
    Eur J Clin Pharmacol 66:899-902. 2010
    ..The aim of this study was to investigate prandial effects on systemic exposure to blonanserin in healthy volunteers, with particular attention paid to the effect of dose timing relative to meal intake...
  67. doi request reprint Comparing the influences of age and disease on distortion in the clock drawing test in Japanese patients with schizophrenia
    Ayako Kaneda
    Department of Neuropsychiatry, Hirosaki University Graduate School of Medicine, Japan
    Am J Geriatr Psychiatry 18:908-16. 2010
    ..The objective of this study was to investigate the influence of schizophrenia and aging on performance in the CDT...
  68. ncbi request reprint Combination of dopamine D2 receptor gene polymorphisms as a possible predictor of treatment-resistance to dopamine antagonists in schizophrenic patients
    Tsuyoshi Kondo
    Department of Neuropsychiatry, University of the Ryukyus Faculty of Medicine, Okinawa 903 0215, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 27:921-6. 2003
    ..4+/-38.0%) or A1 noncarriers without Del alleles (n=10, 65.4+/-29.2%). However, these preliminary results should be replicated in further research with a larger number of the subjects in each haplotype subgroup...
  69. ncbi request reprint Histamine H1-receptor antagonists, promethazine and homochlorcyclizine, increase the steady-state plasma concentrations of haloperidol and reduced haloperidol
    Akihito Suzuki
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, Japan
    Ther Drug Monit 25:192-6. 2003
    ....
  70. ncbi request reprint Relationship between functional dopamine D2 and D3 receptors gene polymorphisms and neuroleptic malignant syndrome
    Kazuo Mihara
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, Japan
    Am J Med Genet B Neuropsychiatr Genet 117:57-60. 2003
    ..The present study suggests that only the TaqI A polymorphism is at least partly useful as a predictor of NMS, but the -141 C Ins/Del and Ser(9)Gly polymorphisms are not...
  71. ncbi request reprint Lack of correlation between the steady-state plasma concentrations of haloperidol and risperidone
    Norio Yasui-Furukori
    Department of Clinical Pharmacology, Hirosaki University School of Medicine, Japan
    J Clin Pharmacol 42:1083-8. 2002
    ....
  72. ncbi request reprint Interaction study between fluvoxamine and quazepam
    Hideto Kanda
    Department of Neuropsychiatry, Yamagata University School of Medicine, Yamagata 990 9585, Japan
    J Clin Pharmacol 43:1392-7. 2003
    ..The present study suggests that fluvoxamine slightly inhibits the metabolism of quazepam to OQ, but this interaction appears to have minimal clinical significance...
  73. pmc Comparison of ankle-brachial pressure index and pulse wave velocity as markers of cognitive function in a community-dwelling population
    Norio Sugawara
    Department of Psychiatry, Hirosaki Aiseikai Hospital, Hirosaki, Japan
    BMC Psychiatry 10:46. 2010
    ..The purpose of this study is to determine the association of the Ankle Brachial pressure Index (ABI) and brachial-ankle Pulse Wave Velocity (ba-PWV) to cognitive impairment in a community-dwelling population...
  74. ncbi request reprint Fexofenadine does not affect omeprazole pharmacokinetics: both are putative P-glycoprotein substrates
    Takenori Takahata
    Department of Clinical Pharmacology, Hirosaki University School of Medicine, Hirosaki, Japan
    Basic Clin Pharmacol Toxicol 94:252-6. 2004
    ....
  75. doi request reprint Clock drawing performance in a community-dwelling population: Normative data for Japanese subjects
    Norio Sugawara
    Department of Psychiatry, Hirosaki Aiseikai Hospital, Aomori, Japan
    Aging Ment Health 14:587-92. 2010
    ..This study also investigates the effect of demographic factors on the performance of the subjects in this task...
  76. ncbi request reprint The effect of aging on the relationship between the cytochrome P450 2C19 genotype and omeprazole pharmacokinetics
    Yukio Ishizawa
    Department of Clinical Pharmacology, Hirosaki University School of Medicine, Hirosaki, Japan
    Clin Pharmacokinet 44:1179-89. 2005
    ..The objective of the present study was to evaluate the effect of aging on the relationship between the CYP2C19 genotype and its phenotype...
  77. ncbi request reprint Lack of significant effect of grapefruit juice on the pharmacokinetics of lansoprazole and its metabolites in subjects with different CYP2C19 genotypes
    Tsukasa Uno
    Department of Pharmacy, Hirosaki University Hospital, Hirosaki, Japan
    J Clin Pharmacol 45:690-4. 2005
  78. doi request reprint The effect of smoking status on the plasma concentration of prolactin already elevated by risperidone treatment in schizophrenia patients
    Chikako Ohta
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:573-6. 2011
    ..232, p<0.01). These findings suggest that smoking status has an impact on prolactin concentration during risperidone treatment. However, further study is required to determine whether these findings have clinical implications...
  79. ncbi request reprint Altered pharmacokinetics and metabolism of valproate after replacement of conventional valproate with the slow-release formulation in epileptic patients
    Tsuyoshi Kondo
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Japan
    Pharmacol Toxicol 90:135-8. 2002
    ....
  80. ncbi request reprint Comparison of prolactin concentrations between haloperidol and bromperidol treatments in schizophrenic patients
    Norio Yasui-Furukori
    Department of Clinical Pharmacology, Hirosaki University School of Medicine, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 26:575-8. 2002
    ..In addition, it is suggested that both drugs show similar pharmacodynamic response despite the difference in pharmacokinetics in the same individuals...
  81. doi request reprint Minor genetic variants of the dopamine D4 receptor (DRD4) polymorphism are associated with novelty seeking in healthy Japanese subjects
    Shoko Tsuchimine
    Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 33:1232-5. 2009
    ..long alleles), there were no significant associations between the DRD4 VNTR polymorphism and any TCI scores. Our results suggest that minor 5-repeat allele is associated with high novelty-seeking scores in healthy Japanese subjects...
  82. pmc No association between CYP2D6 polymorphisms and personality trait in Japanese
    Kumiko Iwashima
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Br J Clin Pharmacol 64:96-9. 2007
    ..CYP2D6 mediates, to some extent, the synthesis of the neurotransmitters, serotonin and dopamine. We investigated a possible association between the genetic polymorphism of CYP2D6 and individual personality trait...
  83. ncbi request reprint Therapeutic effects of bromperidol on the five dimensions of schizophrenic symptoms
    Norio Yasui-Furukori
    Department of Clinical Pharmacology, Hirosaki University, Shool of Medicine, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 26:53-7. 2002
    ..Plasma drug monitoring may have a limited predictive value for improvement in positive symptoms...
  84. doi request reprint Characteristics of the tree-drawing test in chronic schizophrenia
    Ayako Kaneda
    Department of Neuropsychiatry, Hirosaki University Graduate School of Medicine, Hirosaki Aiseikai Hospital, Hirosaki, Japan
    Psychiatry Clin Neurosci 64:141-8. 2010
    ....
  85. ncbi request reprint Effects of itraconazole on the plasma kinetics of quazepam and its two active metabolites after a single oral dose of the drug
    Kimiyasu Kato
    Department of Neuropsychiatry, Yamagata University School of Medicine, Yamagata, Japan
    Ther Drug Monit 25:473-7. 2003
    ..Itraconazole treatment did not affect either of the psychomotor function parameters. The present study thus suggests that CYP 3A4 is partly involved in the metabolism of quazepam...