Ryuichi Wada

Summary

Affiliation: Hirosaki University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint Granulomatous colitis associated with botryomycosis of Propionibacterium acnes
    R Wada
    Department of Pathology, Hirosaki University School of Medicine, Hirosaki, Japan
    Arch Pathol Lab Med 125:1491-3. 2001
  2. ncbi request reprint Nitric oxide generation and poly(ADP ribose) polymerase activation precede beta-cell death in rats with a single high-dose injection of streptozotocin
    Ryuichi Wada
    Department of Pathology, Hirosaki University School of Medicine, 5 Zaifu cho, 036 8562, Hirosaki, Japan
    Virchows Arch 444:375-82. 2004
  3. pmc Chronic granulomatous pleuritis caused by nocardia: PCR based diagnosis by nocardial 16S rDNA in pathological specimens
    R Wada
    Department of Pathology, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562 Japan
    J Clin Pathol 56:966-9. 2003
  4. doi request reprint Granulomatous prostatitis due to Cryptococcus neoformans: diagnostic usefulness of special stains and molecular analysis of 18S rDNA
    R Wada
    Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Prostate Cancer Prostatic Dis 11:203-6. 2008
  5. doi request reprint Profiling of somatostatin receptor subtype expression by quantitative PCR and correlation with clinicopathological features in pancreatic endocrine tumors
    Yoshihito Nakayama
    Departments of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Pancreas 39:1147-54. 2010
  6. ncbi request reprint Role of advanced glycation end products and their receptors in development of diabetic neuropathy
    Ryuichi Wada
    Department of Pathology, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562 Japan
    Ann N Y Acad Sci 1043:598-604. 2005
  7. doi request reprint Small cell carcinoma with skeletal muscle differentiation of urinary bladder
    Nobuhisa Yajima
    Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Pathol Int 59:748-51. 2009
  8. doi request reprint Augmented beta cell loss and mitochondrial abnormalities in sucrose-fed GK rats
    Hiroki Mizukami
    Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Virchows Arch 452:383-92. 2008
  9. ncbi request reprint Pancreatic malignant fibrous histiocytoma, inflammatory myofibroblastic tumor, and inflammatory pseudotumor related to autoimmune pancreatitis: characterization and differential diagnosis
    Hiroki Mizukami
    Department of Pathology, Hirosaki University School of Medicine, and Division of Surgical Pathology, National Hirosaki Hospital, 036 8562, Japan
    Virchows Arch 448:552-60. 2006
  10. ncbi request reprint Pathology and pathogenetic mechanisms of diabetic neuropathy: correlation with clinical signs and symptoms
    Soroku Yagihashi
    Department of Pathology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Diabetes Res Clin Pract 77:S184-9. 2007

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Granulomatous colitis associated with botryomycosis of Propionibacterium acnes
    R Wada
    Department of Pathology, Hirosaki University School of Medicine, Hirosaki, Japan
    Arch Pathol Lab Med 125:1491-3. 2001
    ..The patient developed a postoperative P acnes-induced peritonitis, which subsided with treatment with antibiotics and surgical drainage. The present case indicates that P acnes is one of the possible pathogens for granulomatous colitis...
  2. ncbi request reprint Nitric oxide generation and poly(ADP ribose) polymerase activation precede beta-cell death in rats with a single high-dose injection of streptozotocin
    Ryuichi Wada
    Department of Pathology, Hirosaki University School of Medicine, 5 Zaifu cho, 036 8562, Hirosaki, Japan
    Virchows Arch 444:375-82. 2004
    ..The current study documented serial processes of STZ-induced beta-cell death, starting with NO generation and PARP activation followed by a clearance with macrophages, where the activation of PARP plays a central role in beta-cell death...
  3. pmc Chronic granulomatous pleuritis caused by nocardia: PCR based diagnosis by nocardial 16S rDNA in pathological specimens
    R Wada
    Department of Pathology, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562 Japan
    J Clin Pathol 56:966-9. 2003
    ..In this patient, polymerase chain reaction analysis of 16S ribosomal DNA in pathological specimens was useful in making an accurate diagnosis of nocardiosis and in determining the appropriate treatment...
  4. doi request reprint Granulomatous prostatitis due to Cryptococcus neoformans: diagnostic usefulness of special stains and molecular analysis of 18S rDNA
    R Wada
    Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Prostate Cancer Prostatic Dis 11:203-6. 2008
    ..Careful histological and molecular studies are beneficial to reach the correct diagnosis and to prevent an unfavorable outcome of disseminated cryptococcosis...
  5. doi request reprint Profiling of somatostatin receptor subtype expression by quantitative PCR and correlation with clinicopathological features in pancreatic endocrine tumors
    Yoshihito Nakayama
    Departments of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Pancreas 39:1147-54. 2010
    ..In this paper, we explore the correlation between the SSTR subtype messenger RNA (mRNA) expression and clinicopathological features of PET...
  6. ncbi request reprint Role of advanced glycation end products and their receptors in development of diabetic neuropathy
    Ryuichi Wada
    Department of Pathology, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562 Japan
    Ann N Y Acad Sci 1043:598-604. 2005
    ..The roles of these mechanisms, in particular on the molecular mechanisms of AGE-RAGE interactions in the development of diabetic neuropathy are largely still speculative and yet to be explored...
  7. doi request reprint Small cell carcinoma with skeletal muscle differentiation of urinary bladder
    Nobuhisa Yajima
    Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Pathol Int 59:748-51. 2009
    ..This rare tumor indicates a potential of myoid differentiation in SCC of the urinary bladder and differential diagnosis from primitive neuroectodermal tumor is important because the treatment is different...
  8. doi request reprint Augmented beta cell loss and mitochondrial abnormalities in sucrose-fed GK rats
    Hiroki Mizukami
    Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Virchows Arch 452:383-92. 2008
    ..Current results suggest that nutritional insults like sucrose feeding may exert deleterious effects on mitochondria, resulting in augmented beta cell loss in type 2 diabetes...
  9. ncbi request reprint Pancreatic malignant fibrous histiocytoma, inflammatory myofibroblastic tumor, and inflammatory pseudotumor related to autoimmune pancreatitis: characterization and differential diagnosis
    Hiroki Mizukami
    Department of Pathology, Hirosaki University School of Medicine, and Division of Surgical Pathology, National Hirosaki Hospital, 036 8562, Japan
    Virchows Arch 448:552-60. 2006
    ....
  10. ncbi request reprint Pathology and pathogenetic mechanisms of diabetic neuropathy: correlation with clinical signs and symptoms
    Soroku Yagihashi
    Department of Pathology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Diabetes Res Clin Pract 77:S184-9. 2007
    ..Clinical trials based on this background confirmed that fundamental treatment is in fact beneficial for the prevention and halting of this intractable disorder...
  11. ncbi request reprint Whipple disease diagnosed with PCR using formalin-fixed paraffin-embedded specimens of the intestinal mucosa
    Nobuhisa Yajima
    Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Japan
    Intern Med 52:219-22. 2013
    ..The use of FFPE specimens for PCR should be considered for the prompt diagnosis and prevention of disease progression...
  12. ncbi request reprint Localized amyloidosis at the site of repeated insulin injection in a diabetic patient
    Yasuyoshi Shikama
    Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine
    Intern Med 49:397-401. 2010
    ..Thus, the case suggested that her insulin resistance, i.e. refractoriness of insulin treatment, may be ascribed to poor penetration of injected insulin and human insulin itself or its analogue is amyloidogenic to form a local mass...
  13. ncbi request reprint [An adult with chronic active Epstein-Barr virus infection associated with repeated liver dysfunction]
    Tetsu Endo
    Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine
    Nihon Shokakibyo Gakkai Zasshi 107:1312-8. 2010
    ..Therefore, CAEBV associated with liver dysfunction should be considered during the differential diagnosis of patients showing persistent liver dysfunction...
  14. doi request reprint Pheochromocytoma with histologic transformation to composite type, complicated by watery diarrhea, hypokalemia, and achlorhydria syndrome
    Yuki Kikuchi
    Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Endocr Pract 18:e91-6. 2012
    ..To describe the rare occurrence of histologic transformation of a pheochromocytoma to a composite type of tumor during a long-term follow-up, which was complicated by watery diarrhea, hypokalemia, and achlorhydria syndrome...
  15. ncbi request reprint VIP and calcitonin-producing pancreatic neuroendocrine tumor with watery diarrhea: clinicopathological features and the effect of somatostatin analogue
    Tomoya Kon
    Department of Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    JOP 13:226-30. 2012
    ..Pancreatic neuroendocrine tumor (pNET) secretes various peptide hormones; however, calcitonin hypersecretion is rare. Its clinicopathological significance and treatment is still controversial...
  16. ncbi request reprint [A case of brain nocardiosis successfully treated with minocycline]
    Chieko Suzuki
    Department of Neurology, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    No To Shinkei 58:505-8. 2006
    ..The lesson from the present case is that identification of the type of nocardia by PCR analysis of 16S ribosomal DNA could help accomplish tailor-made antibiotic therapy...
  17. ncbi request reprint [Perspective for the treatment of diabetic neuropathy: translation from molecular studies to bedside]
    Soroku Yagihashi
    Department of Pathology, Hirosaki University School of Medicine
    Rinsho Shinkeigaku 45:966-8. 2005
    ..Consequently, inhibition of hyperglycemia as well as specific intervention of single molecules related to altered cellular signaling is the essential approach for the primary prevention of diabetic neuropathy...
  18. ncbi request reprint Prolonged ischemic conduction failure after reperfusion in diabetic nerve
    Masayuki Baba
    Department of Neurology, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Muscle Nerve 33:350-5. 2006
    ..In conclusion, diabetic nerve shows delayed recovery of ischemic conduction failure after brief ischemia, compared to controls, suggesting that patients with diabetic neuropathy have a worse prognosis when faced with nerve ischemia...
  19. ncbi request reprint Tumor Microenvironment and RIG-I Signaling Molecules in Epstein Barr Virus-Positive and -Negative Classical Hodgkin Lymphoma of the Elderly
    Tsugumi Satoh
    Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine
    J Clin Exp Hematop 54:75-84. 2014
    ..J Clin Exp Hematop 54(1): 75-84, 2014]. ..
  20. ncbi request reprint Disseminated infection and pulmonary embolization of Cunninghamella bertholletiae complicated with hemophagocytic lymphohistiocytosis
    Yoji Hirayama
    Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Japan
    Intern Med 52:2275-9. 2013
    ..C. bertholletiae is aggressive as well as resistant to antifungal agents. This rare species should therefore be taken into consideration as a potential causative agent of zygomycosis. ..
  21. ncbi request reprint Mycobacterial infection of the musculoskeletal tissues: the use of pathological specimens for identification of causative species by PCR-direct sequencing of 16S rDNA
    Noriyuki Nakano
    Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Zaifu cho, Hirosaki, Japan
    Jpn J Infect Dis 63:188-91. 2010
    ..Therefore, PCR-direct sequencing of 16S rDNA containing hypervariable region using pathological specimens is useful for the diagnosis and identification of causative species in mycobacterial infection of musculoskeletal tissues...
  22. ncbi request reprint Promoter methylation and protein expression of the E-cadherin gene in the clinicopathologic assessment of adenoid cystic carcinoma
    Shin ichiro Maruya
    Department of Pathology, Hirosaki University School of Medicine, Hirosaki, Japan
    Mod Pathol 17:637-45. 2004
    ....
  23. ncbi request reprint Immunohistochemical expressions of cytokeratins, mucin core proteins, p53, and neuroendocrine cell markers in epithelial neoplasm of appendix
    Nobuhisa Yajima
    Department of Pathology I, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Hum Pathol 36:1217-25. 2005
    ....
  24. ncbi request reprint Intracytoplasmic immunoglobulin crystals in follicular lymphoma
    Ryuichi Wada
    Department of Pathology, Hirosaki University School of Medicine, Hirosaki, Japan
    Hum Pathol 33:1141-4. 2002
    ..The cases did not accompany paraproteinemia and crystal-storing histiocytosis and appear to follow a favorable clinical outcome...
  25. ncbi request reprint Decreased blood glucose excursion by nateglinide ameliorated neuropathic changes in Goto-Kakizaki rats, an animal model of non-obese type 2 diabetes
    Yoshiro Kitahara
    Pharmaceutical Research Laboratories, Ajinomoto, Kawasaki, Japan
    Metabolism 51:1452-7. 2002
    ..These results suggest that meticulous control of postprandial hyperglycemia is essential to inhibit the development of neuropathy in type 2 diabetes...
  26. ncbi request reprint Nonulcerative keratouveitis as a manifestation of Leptospiral infection in a horse
    Shinya Wada
    Racehorse Hospital, Miho Training Center, The Japan Racing Association JRA, 2500 2 Oaza Mikoma, Miho mura, Inashiki Gun, Ibaraki 300 0493, Japan
    Vet Ophthalmol 6:191-5. 2003
    ..There was also polymerase chain reaction amplification of the leptospiral gene in the kidney. From these findings nonulcerative keratouveitis was believed to be caused by systemic infection with Leptospira...
  27. ncbi request reprint Polymerase chain reaction-restriction fragment length polymorphism analysis of the SzP gene of Streptococcus zooepidemicus isolated from the respiratory tract of horses
    Toru Anzai
    Epizootic Research Station, Equine Research Institute, Japan Racing Association, Shimotsuga gun, Tochigi
    Am J Vet Res 63:1298-301. 2002
    ....
  28. ncbi request reprint Comparison of Salmonella enterica serovar Abortusequi isolates of equine origin by pulsed-field gel electrophoresis and fluorescent amplified-fragment length polymorphism fingerprinting
    Masato Akiba
    Kyusyu Research Station, National Institute of Animal Health, 2702 Chuzan cho, Kagoshima shi, Japan
    Vet Microbiol 92:379-88. 2003
    ..One polymorphic fragment was observed among the 20 S. Abortusequi isolates in Japan. These data indicate the close relation of this agent in Japan. S. Abortusequi strains sharing a common ancestry might have been conserved in Japan...
  29. pmc Systemic inflammation in glucocerebrosidase-deficient mice with minimal glucosylceramide storage
    Hiroki Mizukami
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 109:1215-21. 2002
    ..However, the mutant mice do not accumulate large amounts of glucosylceramide or exhibit classic Gaucher cells in tissues...
  30. ncbi request reprint [Role of cytokine in diabetic neuropathy]
    Soroku Yagihashi
    Department of Pathology I, Hirosaki University School of Medicine
    Nihon Rinsho 63:509-15. 2005