Tomohiro Osanai

Summary

Affiliation: Hirosaki University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint Relationship between salt intake, nitric oxide and asymmetric dimethylarginine and its relevance to patients with end-stage renal disease
    Tomohiro Osanai
    Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    Blood Purif 20:466-8. 2002
  2. ncbi request reprint Decreased plasma and cardiac matrix metalloproteinase activities in patients with coronary artery disease and treated with pravastatin
    Takayuki Fujiwara
    Division of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Eur J Pharmacol 594:146-51. 2008
  3. ncbi request reprint Troglitazone and 15-deoxy-delta(12,14)-prostaglandin J2 inhibit shear-induced coupling factor 6 release in endothelial cells
    Hirofumi Tomita
    The Second Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562 Japan
    Cardiovasc Res 67:134-41. 2005
  4. ncbi request reprint Nicorandil suppresses the increases in plasma level of matrix metalloproteinase activity and attenuates left ventricular remodeling in patients with acute myocardial infarction
    Takayuki Fujiwara
    Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Heart Vessels 22:303-9. 2007
  5. ncbi request reprint Upregulation of soluble vascular endothelial growth factor receptor type 1 by endogenous prostacyclin inhibitor coupling factor 6 in vascular endothelial cells: a role of acidosis-induced c-Src activation
    Takashi Echizen
    Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Hypertens Res 32:182-7. 2009
  6. ncbi request reprint Effect of vasoconstrictor coupling factor 6 on gene expression profile in human vascular endothelial cells: enhanced release of asymmetric dimethylarginine
    Makoto Tanaka
    Second Department of Internal Medicine, Hirosaki University School of Medicine, Osaka, Japan
    J Hypertens 24:489-97. 2006
  7. ncbi request reprint Circulating coupling factor 6 in human hypertension: role of reactive oxygen species
    Tomohiro Osanai
    Second Deparment of Internal Medicine, Hirosaki University School of Medicine, Japan
    J Hypertens 21:2323-8. 2003
  8. ncbi request reprint Increased pericardial fluid level of matrix metalloproteinase-9 activity in patients with acute myocardial infarction: possible role in the development of cardiac rupture
    Kunihiko Kameda
    Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    Circ J 70:673-8. 2006
  9. ncbi request reprint Tumor necrosis factor alpha as an endogenous stimulator for circulating coupling factor 6
    Satoko Sasaki
    The Second Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Cardiovasc Res 62:578-86. 2004
  10. ncbi request reprint Coupling factor 6 downregulates platelet endothelial cell adhesion molecule-1 via c-Src activation and acts as a proatherogenic molecule
    Akiko Kumagai
    Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Atherosclerosis 200:45-50. 2008

Collaborators

Detail Information

Publications54

  1. ncbi request reprint Relationship between salt intake, nitric oxide and asymmetric dimethylarginine and its relevance to patients with end-stage renal disease
    Tomohiro Osanai
    Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    Blood Purif 20:466-8. 2002
    ..The results indicate that ADMA is not only a modulator of salt sensitivity in hypertension but also a cardiovascular risk factor in end-stage renal disease...
  2. ncbi request reprint Decreased plasma and cardiac matrix metalloproteinase activities in patients with coronary artery disease and treated with pravastatin
    Takayuki Fujiwara
    Division of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Eur J Pharmacol 594:146-51. 2008
    ..01). Thus, cardiac oxidative stress and MMP activities are reduced in patients with coronary artery disease and treated with pravastatin, which may be beneficial in preventing and reducing ventricular remodeling...
  3. ncbi request reprint Troglitazone and 15-deoxy-delta(12,14)-prostaglandin J2 inhibit shear-induced coupling factor 6 release in endothelial cells
    Hirofumi Tomita
    The Second Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562 Japan
    Cardiovasc Res 67:134-41. 2005
    ....
  4. ncbi request reprint Nicorandil suppresses the increases in plasma level of matrix metalloproteinase activity and attenuates left ventricular remodeling in patients with acute myocardial infarction
    Takayuki Fujiwara
    Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Heart Vessels 22:303-9. 2007
    ..Nicorandil suppresses the increases in MMP levels and activities and prevents the development of ventricular remodeling in AMI...
  5. ncbi request reprint Upregulation of soluble vascular endothelial growth factor receptor type 1 by endogenous prostacyclin inhibitor coupling factor 6 in vascular endothelial cells: a role of acidosis-induced c-Src activation
    Takashi Echizen
    Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Hypertens Res 32:182-7. 2009
    ..36+/-0.29-fold compared with that in wild-type mice (P<0.05). These indicate that CF6 might increase the expression and release of sFlt-1 in the vessels through acidosis-induced c-Src activation...
  6. ncbi request reprint Effect of vasoconstrictor coupling factor 6 on gene expression profile in human vascular endothelial cells: enhanced release of asymmetric dimethylarginine
    Makoto Tanaka
    Second Department of Internal Medicine, Hirosaki University School of Medicine, Osaka, Japan
    J Hypertens 24:489-97. 2006
    ..We investigated the effect of CF6 on the gene expression profile in human umbilical vein endothelial cells...
  7. ncbi request reprint Circulating coupling factor 6 in human hypertension: role of reactive oxygen species
    Tomohiro Osanai
    Second Deparment of Internal Medicine, Hirosaki University School of Medicine, Japan
    J Hypertens 21:2323-8. 2003
    ..Coupling factor 6 is an endogenous inhibitor of prostacyclin synthesis and might function as an endogenous vasoconstrictor in the fashion of a circulating hormone in rats. We investigated the role of coupling factor 6 in human hypertension...
  8. ncbi request reprint Increased pericardial fluid level of matrix metalloproteinase-9 activity in patients with acute myocardial infarction: possible role in the development of cardiac rupture
    Kunihiko Kameda
    Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    Circ J 70:673-8. 2006
    ..The present study sought to clarify how myocardial MMP-9 activity is related to the pathophysiologies of AMI and cardiac rupture in humans...
  9. ncbi request reprint Tumor necrosis factor alpha as an endogenous stimulator for circulating coupling factor 6
    Satoko Sasaki
    The Second Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Cardiovasc Res 62:578-86. 2004
    ..However, the regulation mechanism for circulating CF6 is unknown. We investigated the role of tumor necrosis factor-alpha (TNF-alpha) in the generation and release of CF6...
  10. ncbi request reprint Coupling factor 6 downregulates platelet endothelial cell adhesion molecule-1 via c-Src activation and acts as a proatherogenic molecule
    Akiko Kumagai
    Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Atherosclerosis 200:45-50. 2008
    ..These suggest that CF6 downregulates PECAM-1 expression via c-Src activation and attenuates shear-induced NO release presumably by suppressing eNOS phosphorylation...
  11. ncbi request reprint Increased level of pericardial insulin-like growth factor-1 in patients with left ventricular dysfunction and advanced heart failure
    Naoki Abe
    Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    J Am Coll Cardiol 48:1387-95. 2006
    ..To test the hypothesis that the cardiac insulin-like growth factor-1 (IGF-1) system is up-regulated in the failing heart, we measured the pericardial (cardiac) and plasma (circulating) IGF-1 levels in coronary artery disease patients...
  12. doi request reprint p122 protein enhances intracellular calcium increase to acetylcholine: its possible role in the pathogenesis of coronary spastic angina
    Reiichi Murakami
    Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Arterioscler Thromb Vasc Biol 30:1968-75. 2010
    ....
  13. doi request reprint Overexpression of coupling factor 6 causes cardiac dysfunction under high-salt diet in mice
    Toshihiro Ashitate
    Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    J Hypertens 28:2243-51. 2010
    ..We investigated the effect of high-salt diet on the cardiac performance and reactive oxygen species generation in coupling factor 6-overexpressing transgenic mice...
  14. doi request reprint Increased serum anandamide level at ruptured plaque site in patients with acute myocardial infarction
    Naotaka Maeda
    Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Fundam Clin Pharmacol 23:351-7. 2009
    ..Anandamide was suggested to be derived from ruptured plaque and may exert beneficial effects in humans...
  15. doi request reprint Impact of telmisartan on coronary stenting in patients with acute myocardial infarction compared with enalapril
    Jin Yokoyama
    Department of Cardiology, Hirosaki University School of Medicine, Zaifu cho 5, Hirosaki, 036 8562, Japan
    Int J Cardiol 132:114-20. 2009
    ..To determine whether telmisartan reduces in-stent restenosis (ISR) after coronary angioplasty using bare metal stent (BMS) in patients with acute myocardial infarction (AMI) compared with an angiotensin converting enzyme (ACE) inhibitor...
  16. doi request reprint Coupling factor 6-induced prostacyclin inhibition is enhanced in vascular smooth muscle cells from spontaneously hypertensive rats
    Tomohiro Osanai
    Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    J Hypertens 27:1823-8. 2009
    ..We investigated the effect of endogenous and exogenous CF6 on prostacyclin generation in cultured vascular smooth muscle cells (VSMCs)...
  17. ncbi request reprint Nicorandil improves cardiac function and clinical outcome in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention: role of inhibitory effect on reactive oxygen species formation
    Hirotsugu Ono
    The Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    Am Heart J 148:E15. 2004
    ..We examined the effect of nicorandil, a hybrid of K(ATP) channel opener and nicotinamide nitrate, on reactive oxygen species (ROS) formation and clinical outcomes after primary percutaneous coronary intervention (PCI) for AMI...
  18. doi request reprint Coupling factor 6 enhances the spontaneous microaggregation of platelets by decreasing cytosolic cAMP irrespective of antiplatelet therapy
    Takanori Sukekawa
    Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Hypertens Res 36:520-7. 2013
    ..CF6 enhanced SMAPs by decreasing cytosolic cAMP. Because it was observed irrespective of antiplatelet agents, CF6 appears to be a novel target for antiplatelet therapy...
  19. ncbi request reprint Circulating level of gelatinase activity predicts ventricular remodeling in patients with acute myocardial infarction
    Toshiro Matsunaga
    Second Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu, Hirosaki, Aomori, Japan
    Int J Cardiol 105:203-8. 2005
    ..We examined whether circulating MMP activity can predict left ventricular (LV) remodeling after AMI in humans...
  20. ncbi request reprint Intracellular signaling for vasoconstrictor coupling factor 6: novel function of beta-subunit of ATP synthase as receptor
    Tomohiro Osanai
    The Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, 036 8562, Japan
    Hypertension 46:1140-6. 2005
    ..These indicate that membrane-bound ATP synthase functions as a receptor for CF6 and may have a previously unsuspected role in the genesis of hypertension by modulating the concentration of intracellular hydrogen...
  21. ncbi request reprint Elevated plasma brain natriuretic peptide levels independent of heart disease in acute ischemic stroke: correlation with stroke severity
    Hirofumi Tomita
    Division of Cerebrovascular Medicine, Hirosaki Stroke Center, Hirosaki, Japan
    Hypertens Res 31:1695-702. 2008
    ..The plasma BNP level transiently increased in patients with LAA independently of heart disease, and reflected infarct volume and the severity of acute ischemic stroke...
  22. ncbi request reprint Plasma concentration of coupling factor 6 and cardiovascular events in patients with end-stage renal disease
    Tomohiro Osanai
    The Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    Kidney Int 64:2291-7. 2003
    ..We investigated cross-sectionally the association between coupling factor 6 (CF6), an endogenous inhibitor of prostacyclin synthesis, and cardiovascular events in 95 hemodialysis patients...
  23. doi request reprint Overexpression of coupling factor 6 attenuates exercise-induced physiological cardiac hypertrophy by inhibiting PI3K/Akt signaling in mice
    Shigeki Sagara
    Department of Cardiology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, Japan
    J Hypertens 30:778-86. 2012
    ..We tested the hypothesis that coupling factor 6 attenuates physiological cardiac hypertrophy induced by exercise and its benefit in mice...
  24. doi request reprint Estrogen attenuates coupling factor 6-induced salt-sensitive hypertension and cardiac systolic dysfunction in mice
    Kei Izumiyama
    Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Hypertens Res 35:539-46. 2012
    ..Estrogen has an important role in the regulation of CF6-mediated pathophysiology, presumably via the downregulation of Rac1...
  25. ncbi request reprint Mutational analysis of Kir6.1 in Japanese patients with coronary spastic angina
    Hirofumi Tomita
    The Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Int J Mol Med 18:589-91. 2006
    ..No mutation that alters primary structure of Kir6.1 was detected in Japanese patients with CSA. The results indicate that abnormality in the primary structure of Kir6.1 may not be involved in the genetic pathogenesis of CSA in humans...
  26. doi request reprint Extracellular matrix metalloproteinase inducer is expressed in the proximal tubular epithelial cells of the human kidney
    Michiko Shimada
    Department of Nephrology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, Japan
    Nephrology (Carlton) 14:171-8. 2009
    ..In this study, we examined EMMPRIN expression in the human kidney with the biopsied specimens, cultured proximal tubular epithelial cells (PTEC) and human mesangial cells (HMC)...
  27. ncbi request reprint Feasibility and safety of thrombectomy with TVAC aspiration catheter system for patients with acute myocardial infarction
    Jin Yokoyama
    Second Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Heart Vessels 21:1-7. 2006
    ..045). Thus, thrombectomy using a TVAC system is feasible, safe, and may have the potential to enhance ST-segment resolution in patients with anterior AMI...
  28. doi request reprint Matrix metalloprotein-9 activation under cell-to-cell interaction between endothelial cells and monocytes: possible role of hypoxia and tumor necrosis factor-α
    Yuko Yamamoto
    Department of Cardiology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562, Japan
    Heart Vessels 27:624-33. 2012
    ..Cell-to-cell interaction between endothelial cells and monocytes promotes proMMP-9 synthesis and secretion. Hypoxia and inflammation are suggested to play an important role in activating proMMP-9, presumably via Hsp90...
  29. ncbi request reprint Roxithromycin is an inhibitor of human coronary artery smooth muscle cells proliferation: a potential ability to prevent coronary heart disease
    Hirofumi Tomita
    The Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    Atherosclerosis 182:87-95. 2005
    ..These results indicate that RXM is an inhibitor of human CASMC proliferation through modulating cell cycle regulatory proteins and inhibiting NF-kappaB signaling pathway...
  30. pmc Re-elevation of T-wave from day 2 to day 4 after successful percutaneous coronary intervention predicts chronic cardiac systolic dysfunction in patients with first anterior acute myocardial infarction
    Fumie Nishizaki
    Department of Cardiology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562, Japan
    Heart Vessels 28:704-13. 2013
    ..Re-elevation ≥0.25 mV of T-wave at the middle of JT interval after successful PCI predicts chronic cardiac systolic dysfunction in patients with first anterior STEMI. ..
  31. ncbi request reprint Enalapril suppresses ventricular remodeling more effectively than losartan in patients with acute myocardial infarction
    Hiroyuki Onodera
    Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Am Heart J 150:689. 2005
    ..We examined the effect of losartan on ventricular remodeling after AMI comparatively with that of enalapril...
  32. ncbi request reprint High plasma level of asymmetric dimethylarginine in patients with acutely exacerbated congestive heart failure: role in reduction of plasma nitric oxide level
    Masayuki Saitoh
    Second Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Heart Vessels 18:177-82. 2003
    ..29, P < 0.05). These findings indicate that ADMA is related to exacerbation of chronic CHF by suppression of the compensatory higher level of plasma NO...
  33. ncbi request reprint Aldosterone causes vasoconstriction in coronary arterioles of rats via angiotensin II type-1 receptor: influence of hypertension
    Motoi Kushibiki
    The Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, 036 8562, Japan
    Eur J Pharmacol 572:182-8. 2007
    ..Aldosterone-induced vasoconstriction is mediated by angiotensin AT1 receptor presumably via oxidative stress...
  34. ncbi request reprint Novel pro-atherogenic molecule coupling factor 6 is elevated in patients with stroke: a possible linkage to homocysteine
    Tomohiro Osanai
    Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Ann Med 42:79-86. 2010
    ..We tested the hypothesis that CF6 is elevated with Hcy in stroke. We also examined the effect of vitamin treatment on CF6 and Hcy levels...
  35. doi request reprint Effects of pravastatin and rosuvastatin on the generation of adiponectin in the visceral adipose tissue in patients with coronary artery disease
    Hiroaki Yokoyama
    Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Fundam Clin Pharmacol 25:378-87. 2011
    ..There was a negative correlation between the plasma adiponectin and VIS PC levels (r = -0.41, P < 0.05). Thus, pravastatin increases adiponectin generation, whereas rosuvastatin does not...
  36. pmc Hydrogen peroxide mobilizes Ca2+ through two distinct mechanisms in rat hepatocytes
    Hirohiko Sato
    Department of Physiology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Acta Pharmacol Sin 30:78-89. 2009
    ..Hydrogen peroxide (H2O2) is produced during liver transplantation. Ischemia/reperfusion induces oxidation and causes intracellular Ca2+ overload, which harms liver cells. Our goal was to determine the precise mechanisms of these processes...
  37. doi request reprint Increased adiponectin synthesis in the visceral adipose tissue in men with coronary artery disease treated with pravastatin: a role of the attenuation of oxidative stress
    Shin Saito
    Division of Cardiology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, Japan
    Atherosclerosis 199:378-83. 2008
    ..05). Thus, adiponectin expression and generation in visceral adipose tissue is increased in men with coronary artery disease treated with pravastatin. Pravastatin-initiated attenuation of oxidative stress could be involved...
  38. ncbi request reprint C-reactive protein-induced upregulation of extracellular matrix metalloproteinase inducer in macrophages: inhibitory effect of fluvastatin
    Naoki Abe
    Second Department of Internal Medicine, Hirosaki University School of Medicine 5 Zaifu, Hirosaki, Aomori, Japan
    Life Sci 78:1021-8. 2006
    ..We examined whether C-reactive protein (CRP) activates macrophages to express EMMPRIN and MMP-9 in vitro and whether statins inhibit it...
  39. ncbi request reprint Coupling factor 6 as a novel vasoactive and proatherogenic peptide in vascular endothelial cells
    Tomohiro Osanai
    Department of Cardiology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, Japan
    Naunyn Schmiedebergs Arch Pharmacol 380:205-14. 2009
    ..It is likely that CF6 contributes to the pathogenesis of cardiovascular diseases, but further intensive investigation is needed...
  40. ncbi request reprint Efficacy and safety of low-dose pioglitazone after primary coronary angioplasty with the use of bare metal stent in patients with acute myocardial infarction and with type 2 diabetes mellitus or impaired glucose tolerance
    Jin Yokoyama
    Department of Cardiology, Hirosaki University School of Medicine, Zaifu cho 5, Hirosaki, 036 8562, Japan
    Heart Vessels 22:146-51. 2007
    ..13 vs 5.16 ml/m(2), P = 0.482). Low-dose pioglitazone seems to have a potential to reduce ISR and does not adversely affect LV remodeling after AMI treated with coronary angioplasty using BMS in patients with type 2 DM or IGT...
  41. ncbi request reprint Hypoxic conditions stimulate the production of angiogenin and vascular endothelial growth factor by human renal proximal tubular epithelial cells in culture
    Masayuki Nakamura
    The Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, 036 8562 Aomori, Japan
    Nephrol Dial Transplant 21:1489-95. 2006
    ..Neovascularization is important for the maintenance of blood flow. We studied the production of angiogenic factors by culturing renal proximal tubular epithelial cells (PTEC) under hypoxic conditions...
  42. ncbi request reprint Imidapril and enalapril similarly inhibit plasma matrix metalloproteinase activities and attenuate left ventricular remodeling in patients with acute myocardial infarction
    Takashi Yokota
    Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan Department of Cardiology and Respiratory Medicine, Aomori City Hospital, Aomori, Japan Second Department of Internal Medicine, Goshogawara City Seihoku Central Hospital, Goshogawara, Japan Department of Cardiology, Hachinohe City Hospital, Hachinohe, Japan and Department of Cardiology and Respiratory Medicine, Aomori Rosai Hospital, Hachinohe, Japan
    J Cardiovasc Pharmacol 63:528-32. 2014
    ..These results demonstrate that imidapril exerts inhibitory effects on plasma MMP activities and attenuates left ventricular remodeling in patients with AMI similar to enalapril...
  43. ncbi request reprint Phospholipase C activity is enhanced in skin fibroblasts obtained from patients with essential hypertension
    Takuo Kosugi
    Second Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    J Hypertens 21:583-90. 2003
    ..In human hypertension, the response of phospholipase C (PLC) to stimuli is enhanced in signal transduction where receptors are coupled to pertussis toxin-sensitive G protein. We investigated PLC activity and its role in human hypertension...
  44. ncbi request reprint Effect of shear stress on asymmetric dimethylarginine release from vascular endothelial cells
    Tomohiro Osanai
    Second Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562 Japan
    Hypertension 42:985-90. 2003
    ..Shear stress at higher magnitudes facilitates the degradation of ADMA, thus returning ADMA release levels to baseline...
  45. ncbi request reprint Coupling factor 6 attenuates CXCR4 expression through the HIF-1α and c-Src pathways and promotes endothelial apoptosis and inflammation
    Akiko Suzuki
    Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Hypertens Res 37:708-15. 2014
    ..Because CXCR4 has an important role in survival function, CF6 may have a role in the progression of arteriosclerosis via these complex mechanisms. ..
  46. ncbi request reprint Correlation of oxidative stress with activity of matrix metalloproteinase in patients with coronary artery disease. Possible role for left ventricular remodelling
    Kunihiko Kameda
    The Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    Eur Heart J 24:2180-5. 2003
    ..Oxidative stress is implicated in the progression of heart failure, and matrix metalloproteinase (MMP) activity is increased in patients with congestive heart failure. We examined the role of oxidative stress on MMP activity in humans...
  47. doi request reprint Coupling factor 6 enhances Src-mediated responsiveness to angiotensin II in resistance arterioles and cells
    Tomohiro Osanai
    Department of Cardiology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Cardiovasc Res 81:780-7. 2009
    ..Here we investigated the direct effect of exogenous CF6 on Ca2+ signalling in cultured VSMCs and the in vivo role of endogenous CF6 in the genesis of hypertension using CF6 transgenic (TG) mice...
  48. ncbi request reprint Nocturnal blood pressure decrease is associated with increased regional cerebral blood flow in patients with a history of ischemic stroke
    Naoto Fujiwara
    Department of Internal Medicine, Reimeikyo Rehabilitation Hospital, Ikarigaseki, Hirosaki, Japan
    J Hypertens 23:1055-60. 2005
    ..It remains controversial whether there is a J-shaped relationship between blood pressure and recurrent stroke among patients with a recent history of ischemic stroke...
  49. ncbi request reprint Enhanced activities and gene expression of phosphodiesterase types 3 and 4 in pressure-induced congestive heart failure
    Koki Takahashi
    Second Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Heart Vessels 16:249-56. 2002
    ..In this animal model, gene expressions of PDE3 and PDE4 were augmented from the hypertrophic stage. PDE3 and PDE4 activities were subsequently enhanced in the CHF stage and seemed to contribute to the development and exacerbation of CHF...
  50. ncbi request reprint Masked excitatory action of noradrenaline on rat islet beta-cells via activation of phospholipase C
    Sechiko Suga
    Department of Physiology, Hirosaki University School of Medicine, 5 Zaifu cho, 036 8562 Hirosaki, Japan
    Pflugers Arch 447:337-44. 2003
    ..This effect is, however, masked by the inhibitory action via a PTX-sensitive pathway also activated by NE...
  51. ncbi request reprint Effect of allopurinol pretreatment on free radical generation after primary coronary angioplasty for acute myocardial infarction
    Weiping Guan
    Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    J Cardiovasc Pharmacol 41:699-705. 2003
    ..In conclusion, allopurinol pretreatment is effective in inhibiting generation of oxygen-derived radicals during reperfusion therapy and the recovery of left ventricular function in humans...
  52. ncbi request reprint Enhanced activity of variant phospholipase C-delta1 protein (R257H) detected in patients with coronary artery spasm
    Takao Nakano
    Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    Circulation 105:2024-9. 2002
    ..We tested the hypothesis that structural abnormality in PLC-delta1 isoform is a cause of the enhanced activity...
  53. ncbi request reprint Effect of losartan on nocturnal blood pressure in patients with stroke: comparison with angiotensin converting enzyme inhibitor
    Tomoyuki Okuguchi
    Department of Internal Medicine, Reimeikyo Rehabilitation Hospital, Ikarigaseki, Japan
    Am J Hypertens 15:998-1002. 2002
    ..We compared the effects of angiotensin II antagonist (losartan) and angiotensin converting enzyme inhibitor (quinapril) on nocturnal blood pressure (BP) and sympathetic nervous activity in patients with hypertension and stroke...
  54. ncbi request reprint Vasoconstrictor effect of aldosterone via angiotensin II type 1 (AT1) receptor: possible role of AT1 receptor dimerization
    Masahiro Yamada
    Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki 036 8562, Japan
    Cardiovasc Res 79:169-78. 2008
    ..The purpose of this study was to confirm the AT1-dependency of the vasoconstrictor effect of aldosterone using AT1a knockout (AT1aKO) mice and to investigate the role of intracellular transglutaminase and AT1 dimerization in this effect...