T Osanai

Summary

Affiliation: Hirosaki University School of Medicine
Country: Japan

Publications

  1. pmc Mitochondrial coupling factor 6 as a potent endogenous vasoconstrictor
    T Osanai
    The Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    J Clin Invest 108:1023-30. 2001
  2. doi request reprint Coupling factor 6-induced activation of ecto-F1F(o) complex induces insulin resistance, mild glucose intolerance and elevated blood pressure in mice
    T Osanai
    Department of Cardiology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Diabetologia 55:520-9. 2012
  3. ncbi request reprint Circulating coupling factor 6 in human hypertension: role of reactive oxygen species
    Tomohiro Osanai
    Second Deparment of Internal Medicine, Hirosaki University School of Medicine, Japan
    J Hypertens 21:2323-8. 2003
  4. ncbi request reprint Plasma concentration of coupling factor 6 and cardiovascular events in patients with end-stage renal disease
    Tomohiro Osanai
    The Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    Kidney Int 64:2291-7. 2003
  5. ncbi request reprint Effect of shear stress on asymmetric dimethylarginine release from vascular endothelial cells
    Tomohiro Osanai
    Second Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562 Japan
    Hypertension 42:985-90. 2003
  6. ncbi request reprint Intracellular signaling for vasoconstrictor coupling factor 6: novel function of beta-subunit of ATP synthase as receptor
    Tomohiro Osanai
    The Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, 036 8562, Japan
    Hypertension 46:1140-6. 2005
  7. doi request reprint Coupling factor 6-induced prostacyclin inhibition is enhanced in vascular smooth muscle cells from spontaneously hypertensive rats
    Tomohiro Osanai
    Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    J Hypertens 27:1823-8. 2009
  8. doi request reprint Coupling factor 6 as a novel vasoactive and proatherogenic peptide in vascular endothelial cells
    Tomohiro Osanai
    Department of Cardiology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, Japan
    Naunyn Schmiedebergs Arch Pharmacol 380:205-14. 2009
  9. doi request reprint Novel pro-atherogenic molecule coupling factor 6 is elevated in patients with stroke: a possible linkage to homocysteine
    Tomohiro Osanai
    Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Ann Med 42:79-86. 2010
  10. ncbi request reprint Cross talk between prostacyclin and nitric oxide under shear in smooth muscle cell: role in monocyte adhesion
    T Osanai
    Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, 036 8562 Japan
    Am J Physiol Heart Circ Physiol 281:H177-82. 2001

Collaborators

Detail Information

Publications44

  1. pmc Mitochondrial coupling factor 6 as a potent endogenous vasoconstrictor
    T Osanai
    The Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    J Clin Invest 108:1023-30. 2001
    ..These findings indicate that mitochondrial coupling factor 6 functions as a potent endogenous vasoconstrictor in the fashion of a circulating hormone and may suggest a new mechanism for hypertension...
  2. doi request reprint Coupling factor 6-induced activation of ecto-F1F(o) complex induces insulin resistance, mild glucose intolerance and elevated blood pressure in mice
    T Osanai
    Department of Cardiology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Diabetologia 55:520-9. 2012
    ..We investigated whether overexpression of CF6 contributes to diabetes and hypertension by intracellular acidosis...
  3. ncbi request reprint Circulating coupling factor 6 in human hypertension: role of reactive oxygen species
    Tomohiro Osanai
    Second Deparment of Internal Medicine, Hirosaki University School of Medicine, Japan
    J Hypertens 21:2323-8. 2003
    ..Coupling factor 6 is an endogenous inhibitor of prostacyclin synthesis and might function as an endogenous vasoconstrictor in the fashion of a circulating hormone in rats. We investigated the role of coupling factor 6 in human hypertension...
  4. ncbi request reprint Plasma concentration of coupling factor 6 and cardiovascular events in patients with end-stage renal disease
    Tomohiro Osanai
    The Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    Kidney Int 64:2291-7. 2003
    ..We investigated cross-sectionally the association between coupling factor 6 (CF6), an endogenous inhibitor of prostacyclin synthesis, and cardiovascular events in 95 hemodialysis patients...
  5. ncbi request reprint Effect of shear stress on asymmetric dimethylarginine release from vascular endothelial cells
    Tomohiro Osanai
    Second Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562 Japan
    Hypertension 42:985-90. 2003
    ..Shear stress at higher magnitudes facilitates the degradation of ADMA, thus returning ADMA release levels to baseline...
  6. ncbi request reprint Intracellular signaling for vasoconstrictor coupling factor 6: novel function of beta-subunit of ATP synthase as receptor
    Tomohiro Osanai
    The Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, 036 8562, Japan
    Hypertension 46:1140-6. 2005
    ..These indicate that membrane-bound ATP synthase functions as a receptor for CF6 and may have a previously unsuspected role in the genesis of hypertension by modulating the concentration of intracellular hydrogen...
  7. doi request reprint Coupling factor 6-induced prostacyclin inhibition is enhanced in vascular smooth muscle cells from spontaneously hypertensive rats
    Tomohiro Osanai
    Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    J Hypertens 27:1823-8. 2009
    ..We investigated the effect of endogenous and exogenous CF6 on prostacyclin generation in cultured vascular smooth muscle cells (VSMCs)...
  8. doi request reprint Coupling factor 6 as a novel vasoactive and proatherogenic peptide in vascular endothelial cells
    Tomohiro Osanai
    Department of Cardiology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, Japan
    Naunyn Schmiedebergs Arch Pharmacol 380:205-14. 2009
    ..It is likely that CF6 contributes to the pathogenesis of cardiovascular diseases, but further intensive investigation is needed...
  9. doi request reprint Novel pro-atherogenic molecule coupling factor 6 is elevated in patients with stroke: a possible linkage to homocysteine
    Tomohiro Osanai
    Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Ann Med 42:79-86. 2010
    ..We tested the hypothesis that CF6 is elevated with Hcy in stroke. We also examined the effect of vitamin treatment on CF6 and Hcy levels...
  10. ncbi request reprint Cross talk between prostacyclin and nitric oxide under shear in smooth muscle cell: role in monocyte adhesion
    T Osanai
    Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, 036 8562 Japan
    Am J Physiol Heart Circ Physiol 281:H177-82. 2001
    ..At sites of vascular damage, prostacyclin synthesis may prevent monocyte adhesiveness for VSMC through the concomitant enhancement of NO production...
  11. ncbi request reprint Mitochondrial coupling factor 6 is present on the surface of human vascular endothelial cells and is released by shear stress
    T Osanai
    Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    Circulation 104:3132-6. 2001
    ..We investigated the possibility of vascular endothelial cells as a source of circulating CF6...
  12. doi request reprint Coupling factor 6 enhances Src-mediated responsiveness to angiotensin II in resistance arterioles and cells
    Tomohiro Osanai
    Department of Cardiology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Cardiovasc Res 81:780-7. 2009
    ..Here we investigated the direct effect of exogenous CF6 on Ca2+ signalling in cultured VSMCs and the in vivo role of endogenous CF6 in the genesis of hypertension using CF6 transgenic (TG) mice...
  13. ncbi request reprint A novel inhibitory effect on prostacyclin synthesis of coupling factor 6 extracted from the heart of spontaneously hypertensive rats
    T Osanai
    Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    J Biol Chem 273:31778-83. 1998
    ....
  14. ncbi request reprint Salt-induced exacerbation of morning surge in blood pressure in patients with essential hypertension
    T Osanai
    The Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    J Hum Hypertens 14:57-64. 2000
    ..We conclude that the morning surge in BP is enhanced by salt loading in the NSS type of essential hyper- tension, presumably by the excessive activation of the sympathetic nervous system. Journal of Human Hypertension (2000) 14, 57-64...
  15. ncbi request reprint Troglitazone and 15-deoxy-delta(12,14)-prostaglandin J2 inhibit shear-induced coupling factor 6 release in endothelial cells
    Hirofumi Tomita
    The Second Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562 Japan
    Cardiovasc Res 67:134-41. 2005
    ....
  16. ncbi request reprint Effect of vasoconstrictor coupling factor 6 on gene expression profile in human vascular endothelial cells: enhanced release of asymmetric dimethylarginine
    Makoto Tanaka
    Second Department of Internal Medicine, Hirosaki University School of Medicine, Osaka, Japan
    J Hypertens 24:489-97. 2006
    ..We investigated the effect of CF6 on the gene expression profile in human umbilical vein endothelial cells...
  17. doi request reprint Coupling factor 6 downregulates platelet endothelial cell adhesion molecule-1 via c-Src activation and acts as a proatherogenic molecule
    Akiko Kumagai
    Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Atherosclerosis 200:45-50. 2008
    ..These suggest that CF6 downregulates PECAM-1 expression via c-Src activation and attenuates shear-induced NO release presumably by suppressing eNOS phosphorylation...
  18. ncbi request reprint Tumor necrosis factor alpha as an endogenous stimulator for circulating coupling factor 6
    Satoko Sasaki
    The Second Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Cardiovasc Res 62:578-86. 2004
    ..However, the regulation mechanism for circulating CF6 is unknown. We investigated the role of tumor necrosis factor-alpha (TNF-alpha) in the generation and release of CF6...
  19. ncbi request reprint Aldosterone causes vasoconstriction in coronary arterioles of rats via angiotensin II type-1 receptor: influence of hypertension
    Motoi Kushibiki
    The Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, 036 8562, Japan
    Eur J Pharmacol 572:182-8. 2007
    ..Aldosterone-induced vasoconstriction is mediated by angiotensin AT1 receptor presumably via oxidative stress...
  20. ncbi request reprint Relationship between salt intake, nitric oxide and asymmetric dimethylarginine and its relevance to patients with end-stage renal disease
    Tomohiro Osanai
    Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    Blood Purif 20:466-8. 2002
    ..The results indicate that ADMA is not only a modulator of salt sensitivity in hypertension but also a cardiovascular risk factor in end-stage renal disease...
  21. doi request reprint Elevated plasma brain natriuretic peptide levels independent of heart disease in acute ischemic stroke: correlation with stroke severity
    Hirofumi Tomita
    Division of Cerebrovascular Medicine, Hirosaki Stroke Center, Hirosaki, Japan
    Hypertens Res 31:1695-702. 2008
    ..The plasma BNP level transiently increased in patients with LAA independently of heart disease, and reflected infarct volume and the severity of acute ischemic stroke...
  22. doi request reprint Upregulation of soluble vascular endothelial growth factor receptor type 1 by endogenous prostacyclin inhibitor coupling factor 6 in vascular endothelial cells: a role of acidosis-induced c-Src activation
    Takashi Echizen
    Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Hypertens Res 32:182-7. 2009
    ..36+/-0.29-fold compared with that in wild-type mice (P<0.05). These indicate that CF6 might increase the expression and release of sFlt-1 in the vessels through acidosis-induced c-Src activation...
  23. ncbi request reprint Enhanced phospholipase C activity in the cultured skin fibroblast obtained from patients with coronary spastic angina: possible role for enhanced vasoconstrictor response
    K Okumura
    Second Department of Internal Medicine, Hirosaki University School of Medicine, Japan
    J Am Coll Cardiol 36:1847-52. 2000
    ..We measured phospholipase C (PLC) activity in the cultured skin fibroblasts obtained from patients with and without coronary spasm and examined its correlation with coronary artery vasomotility...
  24. doi request reprint Vasoconstrictor effect of aldosterone via angiotensin II type 1 (AT1) receptor: possible role of AT1 receptor dimerization
    Masahiro Yamada
    Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki 036 8562, Japan
    Cardiovasc Res 79:169-78. 2008
    ..The purpose of this study was to confirm the AT1-dependency of the vasoconstrictor effect of aldosterone using AT1a knockout (AT1aKO) mice and to investigate the role of intracellular transglutaminase and AT1 dimerization in this effect...
  25. ncbi request reprint High plasma level of asymmetric dimethylarginine in patients with acutely exacerbated congestive heart failure: role in reduction of plasma nitric oxide level
    Masayuki Saitoh
    Second Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Heart Vessels 18:177-82. 2003
    ..29, P < 0.05). These findings indicate that ADMA is related to exacerbation of chronic CHF by suppression of the compensatory higher level of plasma NO...
  26. ncbi request reprint Electron microscopic findings in benign deoxycorticosterone and 11-deoxycortisol-producing adrenal tumor
    T Osanai
    Second Department of Internal Medicine, Hirosaki University School of Medicine, Japan
    Arch Pathol Lab Med 114:829-31. 1990
    ..Thus, the adrenal tumor we examined was composed of the cells derived from the fascicular zone, which are associated with Cushing's syndrome, and the cells of the glomerular zone observed in association with primary aldosteronism...
  27. ncbi request reprint Increased pericardial fluid level of matrix metalloproteinase-9 activity in patients with acute myocardial infarction: possible role in the development of cardiac rupture
    Kunihiko Kameda
    Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    Circ J 70:673-8. 2006
    ..The present study sought to clarify how myocardial MMP-9 activity is related to the pathophysiologies of AMI and cardiac rupture in humans...
  28. ncbi request reprint Circulating level of gelatinase activity predicts ventricular remodeling in patients with acute myocardial infarction
    Toshiro Matsunaga
    Second Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu, Hirosaki, Aomori, Japan
    Int J Cardiol 105:203-8. 2005
    ..We examined whether circulating MMP activity can predict left ventricular (LV) remodeling after AMI in humans...
  29. ncbi request reprint Enhanced activities and gene expression of phosphodiesterase types 3 and 4 in pressure-induced congestive heart failure
    Koki Takahashi
    Second Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Heart Vessels 16:249-56. 2002
    ..In this animal model, gene expressions of PDE3 and PDE4 were augmented from the hypertrophic stage. PDE3 and PDE4 activities were subsequently enhanced in the CHF stage and seemed to contribute to the development and exacerbation of CHF...
  30. ncbi request reprint Phospholipase C activity is enhanced in skin fibroblasts obtained from patients with essential hypertension
    Takuo Kosugi
    Second Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    J Hypertens 21:583-90. 2003
    ..In human hypertension, the response of phospholipase C (PLC) to stimuli is enhanced in signal transduction where receptors are coupled to pertussis toxin-sensitive G protein. We investigated PLC activity and its role in human hypertension...
  31. ncbi request reprint Masked excitatory action of noradrenaline on rat islet beta-cells via activation of phospholipase C
    Sechiko Suga
    Department of Physiology, Hirosaki University School of Medicine, 5 Zaifu cho, 036 8562 Hirosaki, Japan
    Pflugers Arch 447:337-44. 2003
    ..This effect is, however, masked by the inhibitory action via a PTX-sensitive pathway also activated by NE...
  32. ncbi request reprint Nicorandil improves cardiac function and clinical outcome in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention: role of inhibitory effect on reactive oxygen species formation
    Hirotsugu Ono
    The Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    Am Heart J 148:E15. 2004
    ..We examined the effect of nicorandil, a hybrid of K(ATP) channel opener and nicotinamide nitrate, on reactive oxygen species (ROS) formation and clinical outcomes after primary percutaneous coronary intervention (PCI) for AMI...
  33. ncbi request reprint Nocturnal blood pressure decrease is associated with increased regional cerebral blood flow in patients with a history of ischemic stroke
    Naoto Fujiwara
    Department of Internal Medicine, Reimeikyo Rehabilitation Hospital, Ikarigaseki, Hirosaki, Japan
    J Hypertens 23:1055-60. 2005
    ..It remains controversial whether there is a J-shaped relationship between blood pressure and recurrent stroke among patients with a recent history of ischemic stroke...
  34. ncbi request reprint Enhanced activity of variant phospholipase C-delta1 protein (R257H) detected in patients with coronary artery spasm
    Takao Nakano
    Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    Circulation 105:2024-9. 2002
    ..We tested the hypothesis that structural abnormality in PLC-delta1 isoform is a cause of the enhanced activity...
  35. ncbi request reprint Nicorandil suppresses the increases in plasma level of matrix metalloproteinase activity and attenuates left ventricular remodeling in patients with acute myocardial infarction
    Takayuki Fujiwara
    Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Heart Vessels 22:303-9. 2007
    ..Nicorandil suppresses the increases in MMP levels and activities and prevents the development of ventricular remodeling in AMI...
  36. ncbi request reprint C-reactive protein-induced upregulation of extracellular matrix metalloproteinase inducer in macrophages: inhibitory effect of fluvastatin
    Naoki Abe
    Second Department of Internal Medicine, Hirosaki University School of Medicine 5 Zaifu, Hirosaki, Aomori, Japan
    Life Sci 78:1021-8. 2006
    ..We examined whether C-reactive protein (CRP) activates macrophages to express EMMPRIN and MMP-9 in vitro and whether statins inhibit it...
  37. ncbi request reprint Increased level of pericardial insulin-like growth factor-1 in patients with left ventricular dysfunction and advanced heart failure
    Naoki Abe
    Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    J Am Coll Cardiol 48:1387-95. 2006
    ..To test the hypothesis that the cardiac insulin-like growth factor-1 (IGF-1) system is up-regulated in the failing heart, we measured the pericardial (cardiac) and plasma (circulating) IGF-1 levels in coronary artery disease patients...
  38. ncbi request reprint Roxithromycin is an inhibitor of human coronary artery smooth muscle cells proliferation: a potential ability to prevent coronary heart disease
    Hirofumi Tomita
    The Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    Atherosclerosis 182:87-95. 2005
    ..These results indicate that RXM is an inhibitor of human CASMC proliferation through modulating cell cycle regulatory proteins and inhibiting NF-kappaB signaling pathway...
  39. ncbi request reprint Effect of allopurinol pretreatment on free radical generation after primary coronary angioplasty for acute myocardial infarction
    Weiping Guan
    Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    J Cardiovasc Pharmacol 41:699-705. 2003
    ..In conclusion, allopurinol pretreatment is effective in inhibiting generation of oxygen-derived radicals during reperfusion therapy and the recovery of left ventricular function in humans...
  40. ncbi request reprint Mutational analysis of Kir6.1 in Japanese patients with coronary spastic angina
    Hirofumi Tomita
    The Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Int J Mol Med 18:589-91. 2006
    ..No mutation that alters primary structure of Kir6.1 was detected in Japanese patients with CSA. The results indicate that abnormality in the primary structure of Kir6.1 may not be involved in the genetic pathogenesis of CSA in humans...
  41. doi request reprint Hydrogen peroxide mobilizes Ca2+ through two distinct mechanisms in rat hepatocytes
    Hirohiko Sato
    Department of Physiology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Acta Pharmacol Sin 30:78-89. 2009
    ..Hydrogen peroxide (H2O2) is produced during liver transplantation. Ischemia/reperfusion induces oxidation and causes intracellular Ca2+ overload, which harms liver cells. Our goal was to determine the precise mechanisms of these processes...
  42. doi request reprint Decreased plasma and cardiac matrix metalloproteinase activities in patients with coronary artery disease and treated with pravastatin
    Takayuki Fujiwara
    Division of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Eur J Pharmacol 594:146-51. 2008
    ..01). Thus, cardiac oxidative stress and MMP activities are reduced in patients with coronary artery disease and treated with pravastatin, which may be beneficial in preventing and reducing ventricular remodeling...
  43. doi request reprint Increased adiponectin synthesis in the visceral adipose tissue in men with coronary artery disease treated with pravastatin: a role of the attenuation of oxidative stress
    Shin Saito
    Division of Cardiology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, Japan
    Atherosclerosis 199:378-83. 2008
    ..05). Thus, adiponectin expression and generation in visceral adipose tissue is increased in men with coronary artery disease treated with pravastatin. Pravastatin-initiated attenuation of oxidative stress could be involved...
  44. ncbi request reprint Effect of losartan on nocturnal blood pressure in patients with stroke: comparison with angiotensin converting enzyme inhibitor
    Tomoyuki Okuguchi
    Department of Internal Medicine, Reimeikyo Rehabilitation Hospital, Ikarigaseki, Japan
    Am J Hypertens 15:998-1002. 2002
    ..We compared the effects of angiotensin II antagonist (losartan) and angiotensin converting enzyme inhibitor (quinapril) on nocturnal blood pressure (BP) and sympathetic nervous activity in patients with hypertension and stroke...