S Nakaji

Summary

Affiliation: Hirosaki University School of Medicine
Country: Japan

Publications

  1. pmc Comparison of ankle-brachial pressure index and pulse wave velocity as markers of cognitive function in a community-dwelling population
    Norio Sugawara
    Department of Psychiatry, Hirosaki Aiseikai Hospital, Hirosaki, Japan
    BMC Psychiatry 10:46. 2010
  2. pmc Hearing impairment and cognitive function among a community-dwelling population in Japan
    Norio Sugawara
    Department of Psychiatry, Hirosaki Aiseikai Hospital, Hirosaki, 036 8151, Japan
    Ann Gen Psychiatry 10:27. 2011
  3. ncbi request reprint Relationship between lifestyle factors and defecation in a Japanese population
    Shigeyuki Nakaji
    Department of Hygiene, Hirosaki University School of Medicine, 5 Zaifu cho, Japan
    Eur J Nutr 41:244-8. 2002
  4. ncbi request reprint Explanations for the smoking paradox in Japan
    S Nakaji
    Department of Hygiene Hirosaki University School of Medicine, Zaifu cho 5, Hirosaki 036 8562, Japan
    Eur J Epidemiol 18:381-3. 2003
  5. ncbi request reprint Life expectancies in the United Kingdom and Japan
    Shigeyuki Nakaji
    Department of Hygiene, Hirosaki University School of Medicine, Zaifu cho 5, Hirosaki, 036 8562, Japan
    J Public Health Med 25:120-4. 2003
  6. ncbi request reprint A tube-fed liquid formula diet containing dietary fiber increased stool weight in bed-ridden elderly patients
    Shigeyuki Nakaji
    Department of Hygiene, Hirosaki University, Aomori, Japan
    Nutrition 20:955-60. 2004
  7. ncbi request reprint Relationship between mineral and trace element concentrations in drinking water and gastric cancer mortality in Japan
    S Nakaji
    Department of Hygiene, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Nutr Cancer 40:99-102. 2001
  8. ncbi request reprint Environmental factors affect colon carcinoma and rectal carcinoma in men and women differently
    Shigeyuki Nakaji
    Department of Hygiene, Hirosaki University School of Medicine, 5 Zaifu cho, 036 8562, Hirosaki, Japan
    Int J Colorectal Dis 18:481-6. 2003
  9. ncbi request reprint Comparison of etiology of right-sided diverticula in Japan with that of left-sided diverticula in the West
    Shigeyuki Nakaji
    Department of Hygiene, Hirosaki University School of Medicine, Zaifu cho 5, Hirosaki, 036 8562 Japan
    Int J Colorectal Dis 17:365-73. 2002
  10. ncbi request reprint Trends in dietary fiber intake in Japan over the last century
    Shigeyuki Nakaji
    Department of Hygiene, Hirosaki University School of Medicine, Zaifu cho 5, Japan
    Eur J Nutr 41:222-7. 2002

Collaborators

Detail Information

Publications80

  1. pmc Comparison of ankle-brachial pressure index and pulse wave velocity as markers of cognitive function in a community-dwelling population
    Norio Sugawara
    Department of Psychiatry, Hirosaki Aiseikai Hospital, Hirosaki, Japan
    BMC Psychiatry 10:46. 2010
    ..The purpose of this study is to determine the association of the Ankle Brachial pressure Index (ABI) and brachial-ankle Pulse Wave Velocity (ba-PWV) to cognitive impairment in a community-dwelling population...
  2. pmc Hearing impairment and cognitive function among a community-dwelling population in Japan
    Norio Sugawara
    Department of Psychiatry, Hirosaki Aiseikai Hospital, Hirosaki, 036 8151, Japan
    Ann Gen Psychiatry 10:27. 2011
    ..abstract:..
  3. ncbi request reprint Relationship between lifestyle factors and defecation in a Japanese population
    Shigeyuki Nakaji
    Department of Hygiene, Hirosaki University School of Medicine, 5 Zaifu cho, Japan
    Eur J Nutr 41:244-8. 2002
    ..There is a paucity of accurate data regarding any association in the general population between defecation and lifestyle factors such as diet, exercise, physique, and childbirth...
  4. ncbi request reprint Explanations for the smoking paradox in Japan
    S Nakaji
    Department of Hygiene Hirosaki University School of Medicine, Zaifu cho 5, Hirosaki 036 8562, Japan
    Eur J Epidemiol 18:381-3. 2003
    ..Furthermore, low carcinogenic ingredients in Japanese cigarettes and a congenitally-related resistance to smoking-related lung carcinogenesis emerged as the main factors which have brought the 'Japanese smoking paradox'...
  5. ncbi request reprint Life expectancies in the United Kingdom and Japan
    Shigeyuki Nakaji
    Department of Hygiene, Hirosaki University School of Medicine, Zaifu cho 5, Hirosaki, 036 8562, Japan
    J Public Health Med 25:120-4. 2003
    ..Compared with other developed countries, the United Kingdom has exhibited less of an increase in life expectancy over the past 30 years...
  6. ncbi request reprint A tube-fed liquid formula diet containing dietary fiber increased stool weight in bed-ridden elderly patients
    Shigeyuki Nakaji
    Department of Hygiene, Hirosaki University, Aomori, Japan
    Nutrition 20:955-60. 2004
    ..The number of bedridden elderly patients who need a liquid diet has been increasing. We evaluated the usefulness of a tube-fed liquid diet containing cellulose and oligosaccharide for elderly bedridden patients...
  7. ncbi request reprint Relationship between mineral and trace element concentrations in drinking water and gastric cancer mortality in Japan
    S Nakaji
    Department of Hygiene, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Nutr Cancer 40:99-102. 2001
    ..However, the significant relationship of sodium (a component of salt) to gastric carcinogenesis was not observed, although many previous epidemiological studies in Japan have shown this relationship...
  8. ncbi request reprint Environmental factors affect colon carcinoma and rectal carcinoma in men and women differently
    Shigeyuki Nakaji
    Department of Hygiene, Hirosaki University School of Medicine, 5 Zaifu cho, 036 8562, Hirosaki, Japan
    Int J Colorectal Dis 18:481-6. 2003
    ..We examined whether there are differences in the degree of environmental effect on colon cancer and rectal cancer in Japan...
  9. ncbi request reprint Comparison of etiology of right-sided diverticula in Japan with that of left-sided diverticula in the West
    Shigeyuki Nakaji
    Department of Hygiene, Hirosaki University School of Medicine, Zaifu cho 5, Hirosaki, 036 8562 Japan
    Int J Colorectal Dis 17:365-73. 2002
    ..This study compared the etiology of right-sided diverticula in Japan with that of left-sided diverticula in the West...
  10. ncbi request reprint Trends in dietary fiber intake in Japan over the last century
    Shigeyuki Nakaji
    Department of Hygiene, Hirosaki University School of Medicine, Zaifu cho 5, Japan
    Eur J Nutr 41:222-7. 2002
    ..Insufficient intake of dietary fiber (DF) is currently a major problem in the overall promotion of health in the general population in Japan...
  11. ncbi request reprint Seasonal changes in mortality rates from main causes of death in Japan (1970--1999)
    Shigeyuki Nakaji
    Department of Hygiene, Hirosaki University School of Medicine, Zaifu cho 5, Hirosaki, Japan
    Eur J Epidemiol 19:905-13. 2004
    ..It is well recognized that the season of the year exerts an influence on some diseases and causes of death such as coronary heart diseases, stroke, infectious diseases and so on...
  12. ncbi request reprint A population-based study on defecatory conditions in Japanese subjects: methods for self-evaluation
    Shigeyuki Nakaji
    Department of Hygiene, First Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Tohoku J Exp Med 203:97-104. 2004
    ..In conclusion, the study elucidated that personal and subjective evaluation of bowel habits in normal subjects consisted of various factors under the heading of "bowel movement frequency"...
  13. ncbi request reprint Firm measures are required to effect any significant decrease in the Japanese age-adjusted mortality rate from malignant neoplasms for the 21st century
    Shigeyuki Nakaji
    Department of Hygiene, Hirosaki University School of Medicine, Zaifu cho 5, Hirosaki, Japan
    Eur J Epidemiol 19:123-8. 2004
    ....
  14. ncbi request reprint The prevention of colon carcinogenesis in rats by dietary cellulose is greater than the promotive effect of dietary lard as assessed by repeated endoscopic observation
    Shigeyuki Nakaji
    Department of Hygiene, Hirosaki University School of Medicine, Hirosaki, 036 8562 Japan
    J Nutr 134:935-9. 2004
    ..008), independent of the lard concentration. These results suggest that the preventive effect of cellulose against large bowel tumorigenesis is greater than the promotive effect of fat under the current experimental conditions...
  15. ncbi request reprint Effect of decaglycerol mono-oleate on chemiluminescence of human neutrophils
    Q Liu
    Department of Hygiene, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Luminescence 14:327-30. 1999
    ..These results suggest that DGMO downregulates ROS generation by human neutrophils...
  16. ncbi request reprint Effects of zinc on the reactive oxygen species generating capacity of human neutrophils and on the serum opsonic activity in vitro
    H Hasegawa
    Department of Hygiene, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori, 036 8562, Japan
    Luminescence 15:321-7. 2000
    ....
  17. ncbi request reprint Effect of exhaustive exercise on human neutrophils in athletes
    M Yamada
    Department of Hygiene, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    Luminescence 15:15-20. 2000
    ..05). These data indicated that maximal exercise not only mobilized neutrophils from marginated pools into the circulation, but also caused increased ROS generation...
  18. ncbi request reprint Effect of sodium butyrate on reactive oxygen species generation by human neutrophils
    Q Liu
    Dept of Hygiene, Hirosaki University School of Medicine, Aomori, Japan
    Scand J Gastroenterol 36:744-50. 2001
    ..The aims of this study were to investigate the effect sodium butyrate has on reactive oxygen species (ROS) generation by human neutrophils, which are responsible for mucosal injury...
  19. ncbi request reprint Applicability of chemiluminescence to assess the degree of operative stress in patients undergoing spinal surgery
    K Kowatari
    Department of Hygiene, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    Luminescence 14:331-4. 1999
    ....
  20. ncbi request reprint Exercise training and energy restriction decrease neutrophil phagocytic activity in judoists
    K Kowatari
    Department of Hygiene, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    Med Sci Sports Exerc 33:519-24. 2001
    ..To investigate the effects of weight reduction as the result of exercise training and energy restriction on neutrophil function...
  21. ncbi request reprint Effect of decaglycerol monooleate on phagocytosis and respiratory burst activity of human neutrophils: an in vitro study
    Q Liu
    Department of Hygiene, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Japan
    Food Chem Toxicol 38:423-8. 2000
    ..However, this phenomenon was not seen in DGMO-treated neutrophils when DGMO was removed after incubation. The present data suggest that DGMO does not affect phagocytosis of human neutrophils but down-regulates respiratory burst activity...
  22. ncbi request reprint Ecabet sodium inhibits the ability of Helicobacter pylori to induce neutrophil production of reactive oxygen species and interleukin-8
    T Shimoyama
    First Department of Internal Medicine, Hirosaki University School of Medicine, Japan
    J Gastroenterol 36:153-7. 2001
    ..05). Ecabet sodium has preventive effects on the ability of H. pylori to stimulate human neutrophils. It may lead to reduced gastritis activity and decreased oxidative damage of the gastric mucosa in H. pylori-associated gastritis...
  23. ncbi request reprint Depressed humoral immunity after weight reduction in competitive judoists
    Seikou Ohta
    Department of School Health Science, Faculty of Education, Hirosaki University, Japan
    Luminescence 17:150-7. 2002
    ..This study demonstrated that such immunosuppression appeared in the recovery period after the competition rather than immediately before the competition...
  24. pmc Dietary fiber showed no preventive effect against colon and rectal cancers in Japanese with low fat intake: an analysis from the results of nutrition surveys from 23 Japanese prefectures
    S Nakaji
    Department of Hygiene, Hirosaki University School of Medicine Zaifu cho 5, Hirosaki, 036 8562 Japan
    BMC Cancer 1:14. 2001
    ..The aim of this study is to evaluate the association between diet, especially dietary fiber and fat and colorectal cancer in Japan...
  25. doi request reprint The oro-ileal transit of cellulose
    T Oyama
    Department of Social Medicine, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, Aomori, 036 8562, Japan
    J Food Sci 73:H229-34. 2008
    ..However, there were large interindividual variations in the oro-ileal transit time and the percentage of cellulose recovered...
  26. pmc Effects of rugby sevens matches on human neutrophil-related non-specific immunity
    I Takahashi
    Department of Social Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562, Aomori, Japan
    Br J Sports Med 41:13-8. 2007
    ..To evaluate the influences of the accumulative effect of two consecutive rugby sevens matches (Sevens) on aspects of human neutrophil-related non-specific immunity...
  27. ncbi request reprint Circulating cytokines and hormones with immunosuppressive but neutrophil-priming potentials rise after endurance exercise in humans
    K Suzuki
    Department of Hygiene, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    Eur J Appl Physiol 81:281-7. 2000
    ..These results suggested that exercise-induced pathogenesis including previously reported immunosuppression and neutrophil hyper-reactivity might be attributed, at least partly, to the systemic dynamics of the above bioactive substances...
  28. ncbi request reprint Analysis and assessment of the capacity of neutrophils to produce reactive oxygen species in a 96-well microplate format using lucigenin- and luminol-dependent chemiluminescence
    H Hasegawa
    Department of Hygiene, Hirosaki University School of Medicine, Aomori, Japan
    J Immunol Methods 210:1-10. 1997
    ..Such microplate-based multiple measurements facilitate the accurate assessment of phagocytic function...
  29. ncbi request reprint Contribution of nitric oxide synthase to human neutrophil chemiluminescence
    S Kudoh
    Department of Hygiene, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori, 036 8562, Japan
    Luminescence 14:335-9. 1999
    ..3 +/- 15.0%. Therefore, approximately 12% of the LPS-primed luminol-dependent CL decrease induced by L-NAME indicated the contribution of NOS activity to the CL response...
  30. ncbi request reprint Evaluation of the association between serum anti-Lewis X antibody and inflammatory infiltration into the gastric mucosa infected with Helicobacter pylori
    T Shimoyama
    First Department of Internal Medicine, Hirosaki University School of Medicine, Japan
    Dig Liver Dis 33:326-9. 2001
    ..Lipopolysaccharides of Helicobacter pylori have an antigenic structure that mimics Lewis X occurring in gastric mucosa. The pathogenic role of antigenic mimicry in Helicobacter pylori-induced gastritis has been of recent interest...
  31. pmc Effect of incorporating low intensity exercise into the recovery period after a rugby match
    M Suzuki
    Hirosaki University, School of Medicine, Zaifu cho 5, Hirosaki 036 8562, Aomori, Japan
    Br J Sports Med 38:436-40. 2004
    ..Rugby is an intense sport which appears to impose psychological and physiological stress on players. However, there have been few studies of the most appropriate resting techniques to deliver effective recovery from a match...
  32. ncbi request reprint Effect of interferon-alpha on production of reactive oxygen species by human neutrophils
    T Koie
    Department of Hygiene, Hirosaki University School of Medicine, Zaifu-cho 5, Hirosaki, Aomori, 036-8562 Japan
    Luminescence 16:39-43. 2001
    ..The increase of LgCL might be due to the inhibitory effect of IFN-alpha on myeloperoxidase degranulation, in view of the decreased LmCL responses...
  33. ncbi request reprint Effect of 6 months' training on the reactive oxygen species production capacity of neutrophils and serum opsonic activity in judoists
    Masashi Miura
    Department of Hygiene, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    Luminescence 20:1-7. 2005
    ..This could be categorized as a long-term training effect. However, no such change was seen in ROS...
  34. ncbi request reprint Effects of weight reduction on neutrophil phagocytic activity and oxidative burst activity in female judoists
    Masahiro Suzuki
    Department of Hygiene, Hirosaki University School of Medicine, Hirosaki, Aomori, Japan
    Luminescence 18:214-7. 2003
    ..Therefore, to avoid this problem, female judoists are recommended to keep their weight within those limits determined by their class, and which can be reduced by exercise...
  35. pmc Change in the capability of reactive oxygen species production by neutrophils following weight reduction in female judoists
    Makoto Yaegaki
    Department of Social Medicine, Hirosaki University School of Medicine, Zaifu cho, Hirosaki, Aomori, Japan
    Br J Sports Med 41:322-7. 2007
    ..Few studies exist for athletes on the weight reduction-mediated changes in neutrophil function and related activities such as reactive oxygen species (ROS) production capability, phagocytic activity (PA) and serum opsonic activity (SOA)...
  36. doi request reprint The effects of a two-hour judo training session on the neutrophil immune functions in university judoists
    Takashi Umeda
    Department of Social Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562 Aomori, Japan
    Luminescence 23:49-53. 2008
    ....
  37. ncbi request reprint Inhibitory factors of serum opsonic activity in serum from patients with chronic renal failure
    T Kikuchi
    Department of Hygiene, Hirosaki University, School of Medicine, Aomori, Japan
    Ren Fail 19:137-44. 1997
    ..The presumed molecular weight of these fractions is between 300 and 2800 daltons. These findings indicate that the inhibitory factors of serum opsonic activity may belong to middle molecules...
  38. ncbi request reprint Pattern of dietary fiber intake among the Japanese general population
    S Fukuda
    First Department of Internal Medicine, Hirosaki University School of Medicine, Aomori, Japan
    Eur J Clin Nutr 61:99-103. 2007
    ..To evaluate the dietary fiber (DF) intake pattern among the Japanese general population...
  39. ncbi request reprint Adverse effects of energy restriction on changes in immunoglobulins and complements during weight reduction in judoists
    T Umeda
    Department of Hygiene, Hirosaki University School of Medicine, Aomori, Japan
    J Sports Med Phys Fitness 44:328-34. 2004
    ..A preliminary study to investigate the combined effects of dietary restriction and weight reduction through exercise on markers of immune function in college judoists before and after a single competition...
  40. ncbi request reprint No preventive effect of dietary fiber against colon cancer in the Japanese population: a cross-sectional analysis
    Shigeyuki Nakaji
    Department of Hygiene, Hirosaki University School of Medicine, Zaifu cho 5, Hirosaki 036 8562, Japan
    Nutr Cancer 45:156-9. 2003
    ..In conclusion, our data do not demonstrate any protective effect of DF on colon cancer in subjects with a low fat intake (Japanese subjects), which supports Fuchs' findings in subjects with high fat intake (U.S. subjects)...
  41. ncbi request reprint Impact of a competitive marathon race on systemic cytokine and neutrophil responses
    Katsuhiko Suzuki
    Department of Hygiene, Hirosaki University School of Medicine, Aomori, Japan
    Med Sci Sports Exerc 35:348-55. 2003
    ..To investigate whether cytokines and neutrophils mediate exercise-related pathogenesis, we examined their responses and possible association after exhaustive exercise...
  42. ncbi request reprint The main neutrophil and neutrophil-related functions may compensate for each other following exercise-a finding from training in university judoists
    Noriko Mochida
    Department of Social Medicine, Hirosaki University School of Medicine, Zaifu cho 5, Hirosaki, 036 8562 Aomori, Japan
    Luminescence 22:20-8. 2007
    ....
  43. ncbi request reprint The prevalence of obesity and its relationship with lifestyle factors in Jamaica
    Manabu Ichinohe
    Department of Otorhinolaryngology, Hirosaki University School of Medicine, Hirosaki, Japan
    Tohoku J Exp Med 207:21-32. 2005
    ..In conclusions, these findings suggest that social and lifestyle factors such as the educational level, marital status and dietary habits of the general population influence Jamaican obesity...
  44. doi request reprint Knee osteoarthritis, knee joint pain and aging in relation to increasing serum hyaluronan level in the Japanese population
    R Inoue
    Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan
    Osteoarthritis Cartilage 19:51-7. 2011
    ..To investigate relationship between serum hyaluronan (HA) level and the presence and severity of radiographic knee osteoarthritis (OA) as well as degree of knee pain in Japanese population...
  45. pmc Gender differences in physical and psychological stress responses among college judoists undergoing weight reduction
    T Umeda
    Department of Hygiene, Hirosaki University School of Medicine, Aomori
    Environ Health Prev Med 4:146-50. 1999
    ..Although the men and women had the same BW reduction, significant physical stress response was seen only in men, and psychological stress due to weight reduction and mental pressure of an upcoming competition were seen more in women...
  46. ncbi request reprint Changes in intraluminal pressure in rat large intestines with aging and effects of dietary fiber
    H Murakami
    First Department of Internal Medicine, Hirosaki University School of Medicine, Japan
    Dig Dis Sci 46:1247-54. 2001
    ..This result suggests that long-term ingestion of dietary fiber might have a prophylactic effect on the development of diverticula...
  47. ncbi request reprint Differences in carcinogenesis by the length of carcinogen exposure period in rat colon
    T Endo
    Department of Hygiene, Hirosaki University School of Medicine, Japan
    Dig Dis Sci 46:109-17. 2001
    ..Thus, our results suggest that the carcinogenesis patterns in rat colon are dependent on the length of exposure to carcinogen and that K-ras mutations were partly involved in a subset of them...
  48. doi request reprint Effects of intense exercise on the physiological and mental condition of female university judoists during a training camp
    Takashi Umeda
    Department of Social Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    J Sports Sci 26:897-904. 2008
    ..032). Our results suggest that intense exercise during training camps for female judoists leads to the appearance and accumulation of mental and physical fatigue, which are related to each other...
  49. ncbi request reprint Effects of cellulose supplementation on fecal consistency and fecal weight
    Kazuma Danjo
    Department of Social Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Dig Dis Sci 53:712-8. 2008
    ..However, these changes were not observed in the constipated group...
  50. doi request reprint Effects of a bout of traditional and original sumo training on neutrophil immune function in amateur university sumo wrestlers
    Takashi Umeda
    Department of Social Medicine, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    Luminescence 23:115-20. 2008
    ..In this time, although OBA increased, PA decreased after training. Compensation between PA and reactive oxygen species production may exist to maintain the overall integrity of the neutrophil immune function...
  51. ncbi request reprint [Effects of gender-related weight reduction on the physical condition of male and female college judoists]
    Takashi Umeda
    Department of Hygiene, Hirosaki University School of Medicine, Hirosaki City, Aomori, Japan
    Nihon Eiseigaku Zasshi 59:326-34. 2004
    ....
  52. ncbi request reprint Systemic inflammatory response to exhaustive exercise. Cytokine kinetics
    Katsuhiko Suzuki
    Department of Hygiene, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    Exerc Immunol Rev 8:6-48. 2002
    ..The sources and stimuli of cytokine production are not fully elucidated at present, but several hypotheses based on recent experimental evidence are discussed in this review herein...
  53. ncbi request reprint A competitive marathon race decreases neutrophil functions in athletes
    Daisuke Chinda
    Department of Hygiene, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 0368562, Japan
    Luminescence 18:324-9. 2003
    ..The increase in total neutrophil counts might reflect a compensatory response to counteract the decrease in neutrophil functions...
  54. ncbi request reprint Effects of long-distance running on serum opsonic activity measured by chemiluminescence
    Daisuke Saito
    Department of Hygiene, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    Luminescence 18:122-4. 2003
    ..The increase of ROS production may suggest that serum opsonic activity is accelerated after running 30 km. Thus, serum opsonic activity might not play a significant role in the susceptibility to infection after long-distance running...
  55. ncbi request reprint Break point of serum creatine kinase release after endurance exercise
    Manabu Totsuka
    Department of Health and Physical Education, Faculty of Education, Hirosaki University, Hirosaki, Aomori 036 8560, Japan
    J Appl Physiol (1985) 93:1280-6. 2002
    ..Thus the break point of CK release after endurance exercise under these conditions is 300-500 IU/l, two or three times higher than in the resting condition, and is associated with properties of the QFM...
  56. ncbi request reprint Adverse effects of energy restriction on myogenic enzymes in judoists
    Takashi Umeda
    Department of Hygiene, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    J Sports Sci 22:329-38. 2004
    ....
  57. pmc Helicobacter pylori water soluble surface proteins prime human neutrophils for enhanced production of reactive oxygen species and stimulate chemokine production
    T Shimoyama
    First Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    J Clin Pathol 56:348-51. 2003
    ..The aim of this study was to examine the effects of H pylori water extracts on the oxidative burst and chemokine production of human neutrophils...
  58. doi request reprint Measuring neutrophil functions might be a good predictive marker of overtraining in athletes
    Makoto Yaegaki
    Department of Social Medicine, Hirosaki University Graduate School of Medicine, Zaifu cho 5, Hirosaki, Aomori 036 8562, Japan
    Luminescence 23:281-6. 2008
    ..Therefore, regularly examining neutrophil functions such as ROS and PA might be a good preventative measure against overtraining in athletes participating in training camps...
  59. doi request reprint Effects of 2.5-hour sumo training on serum opsonic activity
    Arata Kojima
    Department of Social Medicine, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562 Aomori, Japan
    Luminescence 24:224-9. 2009
    ..In conclusion, daily actual sumo training for 2.5 h increases SOA, thus possibly activating the reactive oxygen species production of neutrophils...
  60. ncbi request reprint Inhibitory effect of small amounts of cellulose on colonic carcinogenesis with low-dose carcinogen
    Satoru Iwane
    First Department of Internal Medicine, Hirosaki University School of Medicine, Japan
    Dig Dis Sci 47:1257-65. 2002
    ..It is likely that the inhibitory effect of 3% cellulose could be confirmed only by a long-term experiment on carcinogenesis following the administration of a low dose of carcinogen...
  61. ncbi request reprint Production of chemokines and reactive oxygen species by human neutrophils stimulated by Helicobacter pylori
    Tadashi Shimoyama
    First Department of Internal Medicine, Hirosaki University School of Medicine, Japan
    Helicobacter 7:170-4. 2002
    ..This study examined the ability of Helicobacter pylori to induce production of ROS and chemokines by human neutrophils...
  62. ncbi request reprint Gender differences in the psychological response to weight reduction in judoists
    Yoshiko Yoshioka
    Dept of Hygiene, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    Int J Sport Nutr Exerc Metab 16:187-98. 2006
    ..The psychological stress may be caused by anxiety engendered by the overall concept of weight reduction before actual weight reduction in females, whereas in males it may be caused by the actual weight reduction...
  63. ncbi request reprint Confounding by dietary factors in case-control studies on the efficacy of cancer screening in Japan
    Ko Jun Suzuki
    Department of Hygiene, Hirosaki University School of Medicine, Hirosaki, Japan
    Eur J Epidemiol 20:73-8. 2005
    ..The value of the odds ratio will probably not decrease, but it might increase when other dietary factors or smoking are taken into consideration...
  64. ncbi request reprint The acute response of neutrophil function to a bout of judo training
    Daisuke Chinda
    Department of Hygiene, Hirosaki University School of Medicine, Hirosaki, Aomori, Japan
    Luminescence 18:278-82. 2003
    ..In conclusion, judo training induced a decrease in phagocytic activity through the lowered expression of CD11b and CD16 on the surface of neutrophils, and increased the oxidative burst activity of neutrophils...
  65. ncbi request reprint Exhaustive exercise and type-1/type-2 cytokine balance with special focus on interleukin-12 p40/p70
    Katsuhiko Suzuki
    Department of Hygiene, Hirosaki University School of Medicine, Aomori, Japan
    Exerc Immunol Rev 9:48-57. 2003
    ....
  66. ncbi request reprint The fermentation of different dietary fibers is associated with fecal clostridia levels in men
    Daisuke Chinda
    Department of Hygiene, Hirosaki University School of Medicine, Hirosaki, Japan
    J Nutr 134:1881-6. 2004
    ..The hydrogen breath test results of DFs depend on both the type of DF and the individual colonic microflora. The amount and constitution of colonic microflora might be predicted by the hydrogen-breath test using different DFs...
  67. ncbi request reprint Bowel habits before and during menses in Japanese women of climacteric age: a population based study
    Shinsaku Fukuda
    First Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    Tohoku J Exp Med 206:99-104. 2005
    ..Our data thus suggest that the changes in the bowel habits of women of climacteric age at menstruation are greater for those suffering from constipation than those who are not...
  68. ncbi request reprint New method for the determination of fecal consistency and its optimal value in the general population
    Shigeyuki Nakaji
    Department of Hygiene, Hirosaki University School of Medicine, Japan
    J Gastroenterol Hepatol 17:1278-82. 2002
    ..We developed a new method to measure fecal consistency and studied the relationship between fecal consistency and other fecal factors, including water content and weight...
  69. ncbi request reprint Low-level laser irradiation attenuates production of reactive oxygen species by human neutrophils
    Yuji Fujimaki
    Department of Hygiene, Hirosaki University School of Medicine, Japan
    J Clin Laser Med Surg 21:165-70. 2003
    ..The aim of this study was to examine the effects of low-level laser therapy (LLLT) on production of reactive oxygen (ROS) species by human neutrophils...
  70. ncbi request reprint Characteristics of attenuating effects of rebamipide, an anti-ulcer agent, on oxidative burst of human neutrophils
    Tadashi Shimoyama
    First Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    J Pharmacol Sci 91:153-7. 2003
    ..Thus, addition of rebamipide to H(2)-receptor antagonists can be considered for the treatment of gastric mucosal injury associated with oxidative stress...
  71. ncbi request reprint The decreasing burden of gastric cancer in Japan
    Masashi Matsuzaka
    Department of Social Medicine, Hirosaki University School of Medicine, Japan
    Tohoku J Exp Med 212:207-19. 2007
    ..In the future, changes in these environmental factors and progresses in the diagnosis of and therapeutic strategies for gastric cancer will lead to further decrease in the incidence and mortality rates of this disease in Japan...
  72. doi request reprint Hypercholesterolemia accelerates bone loss in postmenopausal women
    A Tarakida
    Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, Aomori, Japan
    Climacteric 14:105-11. 2011
    ..To clarify the effect of lipid profiles on postmenopausal bone loss using a longitudinal method and to determine whether cytokines are involved in bone loss...
  73. doi request reprint Are individuals with lower neutrophil oxidative burst activity more prone to Helicobacter pylori infection?
    Masashi Matsuzaka
    Department of Social Medicine, Hirosaki University Graduate School of Medicine, Zaifu cho 5, Hirosaki, 036 8562 Aomori, Japan
    Luminescence 23:132-8. 2008
    ..It was concluded that H. pylori infection does not lower OBA, but those individuals in whom OBA was lower were more prone to H. pylori infection...
  74. doi request reprint Comparison of a stool antigen test and serology for the diagnosis of Helicobacter pylori infection in mass survey
    Tadashi Shimoyama
    Department of Gastroenterology and Department of Social Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Helicobacter 14:87-90. 2009
    ..We examined H. pylori infection by both serology and stool antigen test in a mass survey and compared the results to estimate applicability of stool antigen test for mass survey...
  75. doi request reprint The recovery rate at the human terminal ileum of an orally administered non-digestive oligosaccharide (raffinose)
    Sen Shimaya
    Department of Social Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan
    Int J Food Sci Nutr 60:344-51. 2009
    ..6+/-0.7 h and 4.9+/-0.7 h, respectively. In conclusion, approximately 100% of ingested raffinose was recovered in the terminal ileum in the present study. This corresponds with the present generally accepted definition of a dietary fibre...
  76. ncbi request reprint Prognostic factors for survival in stage III non-small-cell lung cancer treated with definitive radiation therapy: impact of tumor volume
    Kiyoshi Basaki
    Department of Radiology, Hirosaki University School of Medicine, Aomori, Japan
    Int J Radiat Oncol Biol Phys 64:449-54. 2006
    ..To investigate the impact of tumor volume on overall survival in patients with Stage III non-small-cell lung cancer (NSCLC) treated with definitive radiation therapy (RT)...
  77. ncbi request reprint Comparison of the amount of pectin in the human terminal ileum with the amount of orally administered pectin
    Daisuke Saito
    Department of Hygiene, Hirosaki University School of Medicine, Aomori, Japan
    Nutrition 21:914-9. 2005
    ..We compared the amount of pectin in the human terminal ileum with that of orally administered pectin...
  78. ncbi request reprint Raised plasma G-CSF and IL-6 after exercise may play a role in neutrophil mobilization into the circulation
    Mutsuo Yamada
    Department of Hygiene, Hirosaki University School of Medicine, Aomori 036 8562, Japan
    J Appl Physiol 92:1789-94. 2002
    ..05). The increase in the levels of plasma G-CSF and IL-6 after intensive exercise may play a role in the mobilization of neutrophils into the circulatory system...
  79. ncbi request reprint Morphologic criteria using biopsy specimens to define the risk of gastric cancer in patients with Helicobacter pylori infection
    Shinsaku Fukuda
    First Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    Jpn J Clin Oncol 33:396-8. 2003
    ..Calculation of PCA, which requires only two biopsy specimens, may be useful to define the patients at high or low risk of intestinal-type gastric cancer among patients infected with H. pylori...
  80. ncbi request reprint Nutritional effects of supplementing liquid-formula diet with dietary fiber on elderly bed-ridden patients
    Seiko Wada
    Department of Nursing, Akita Keijo Junior College, Odate 017 0046, Japan
    Tohoku J Exp Med 203:9-16. 2004
    ....