Fumiaki Mori

Summary

Affiliation: Hirosaki University School of Medicine
Country: Japan

Publications

  1. doi request reprint Ubiquilin immunoreactivity in cytoplasmic and nuclear inclusions in synucleinopathies, polyglutamine diseases and intranuclear inclusion body disease.
    Fumiaki Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562, Japan
    Acta Neuropathol 124:149-51. 2012
  2. pmc Analysis of microRNA from archived formalin-fixed paraffin-embedded specimens of amyotrophic lateral sclerosis
    Koichi Wakabayashi
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562, Japan
    Acta Neuropathol Commun 2:173. 2014
  3. doi request reprint Autophagy-related proteins (p62, NBR1 and LC3) in intranuclear inclusions in neurodegenerative diseases
    Fumiaki Mori
    Department of Neuropathology, Cell Biology and Histology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Neurosci Lett 522:134-8. 2012
  4. doi request reprint Ubiquitin-related proteins in neuronal and glial intranuclear inclusions in intranuclear inclusion body disease
    Fumiaki Mori
    Department of Neuropathology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Pathol Int 62:407-11. 2012
  5. doi request reprint FUS immunoreactivity of neuronal and glial intranuclear inclusions in intranuclear inclusion body disease
    F Mori
    Departments of Neuropathology Neuroanatomy, Cell Biology and Histology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Neuropathol Appl Neurobiol 38:322-8. 2012
  6. ncbi request reprint Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain
    F Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Neurosci Lett 285:57-60. 2000
  7. ncbi request reprint Widespread calcium deposits, as detected using the alizarin red S technique, in the nervous system of rats treated with dimethyl mercury
    F Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Japan
    Neuropathology 20:210-5. 2000
  8. ncbi request reprint Thiophene, a sulfur-containing heterocyclic hydrocarbon, causes widespread neuronal degeneration in rats
    F Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Japan
    Neuropathology 20:283-8. 2000
  9. ncbi request reprint Convulsive effects of thiophene, a heterocyclic hydrocarbon: behavioral, electrographic and c-Fos immunocytochemical studies
    F Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Japan
    Neuropathology 20:304-8. 2000
  10. ncbi request reprint Alpha-synuclein immunoreactivity in normal and neoplastic Schwann cells
    Fumiaki Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Acta Neuropathol 103:145-51. 2002

Collaborators

Detail Information

Publications139 found, 100 shown here

  1. doi request reprint Ubiquilin immunoreactivity in cytoplasmic and nuclear inclusions in synucleinopathies, polyglutamine diseases and intranuclear inclusion body disease.
    Fumiaki Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562, Japan
    Acta Neuropathol 124:149-51. 2012
  2. pmc Analysis of microRNA from archived formalin-fixed paraffin-embedded specimens of amyotrophic lateral sclerosis
    Koichi Wakabayashi
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562, Japan
    Acta Neuropathol Commun 2:173. 2014
    ..This study investigated whether formalin-fixed paraffin-embedded (FFPE) specimens from postmortem cases of neurodegenerative disorders would be suitable for miRNA profiling...
  3. doi request reprint Autophagy-related proteins (p62, NBR1 and LC3) in intranuclear inclusions in neurodegenerative diseases
    Fumiaki Mori
    Department of Neuropathology, Cell Biology and Histology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Neurosci Lett 522:134-8. 2012
    ..2%), DRPLA (5.5%) and INIBD (13.2%) and negative for LC3 in MJD, DRPLA and INIBD, except for one case of INIBD. These findings suggest that autophagy-lysosome pathway is not involved in the formation/degradation of NIIs...
  4. doi request reprint Ubiquitin-related proteins in neuronal and glial intranuclear inclusions in intranuclear inclusion body disease
    Fumiaki Mori
    Department of Neuropathology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Pathol Int 62:407-11. 2012
    ..05). These findings suggest that proteins related to ubiquitination and proteasomal degradation are involved in the formation of INI in INIBD...
  5. doi request reprint FUS immunoreactivity of neuronal and glial intranuclear inclusions in intranuclear inclusion body disease
    F Mori
    Departments of Neuropathology Neuroanatomy, Cell Biology and Histology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Neuropathol Appl Neurobiol 38:322-8. 2012
    ..However, the extent and frequency of FUS-immunoreactive structures in INIBD are uncertain...
  6. ncbi request reprint Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain
    F Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Neurosci Lett 285:57-60. 2000
    ..Therefore, RyR expression undergoes dynamic changes during the early postnatal period, when neurons are undergoing structural and functional differentiation...
  7. ncbi request reprint Widespread calcium deposits, as detected using the alizarin red S technique, in the nervous system of rats treated with dimethyl mercury
    F Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Japan
    Neuropathology 20:210-5. 2000
    ..These findings suggest that widespread calcium deposition could occur in the nervous system following dimethyl mercury exposure, and that in the rat the mechanism of calcium deposition differs depending upon the brain region...
  8. ncbi request reprint Thiophene, a sulfur-containing heterocyclic hydrocarbon, causes widespread neuronal degeneration in rats
    F Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Japan
    Neuropathology 20:283-8. 2000
    ..These findings suggest that thiophene causes widespread neuronal degeneration in rats and that the regional distribution of brain lesions induced by thiophene is different from that caused by methyl mercury poisoning...
  9. ncbi request reprint Convulsive effects of thiophene, a heterocyclic hydrocarbon: behavioral, electrographic and c-Fos immunocytochemical studies
    F Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Japan
    Neuropathology 20:304-8. 2000
    ..In contrast, c-Fos was induced widely in the cerebral cortex and hippocampus, and was most marked in the dentate gyrus. These findings suggest that the hippocampus plays a crucial role in seizure onset following thiophene injection...
  10. ncbi request reprint Alpha-synuclein immunoreactivity in normal and neoplastic Schwann cells
    Fumiaki Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Acta Neuropathol 103:145-51. 2002
    ..No beta- or gamma-synuclein immunoreactivity was found in those cells. These results indicate that in the PNS, alpha-synuclein is a useful marker of Schwann cells and that it is not involved in tumorigenesis...
  11. ncbi request reprint Immunohistochemical comparison of alpha- and beta-synuclein in adult rat central nervous system
    Fumiaki Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Brain Res 941:118-26. 2002
    ..Furthermore, the distribution of alphaS-positive neurons is similar to that of intraneuronal inclusions in alphaS transgenic animals as well as in human alpha-synucleinopathies...
  12. ncbi request reprint Demonstration of alpha-synuclein immunoreactivity in neuronal and glial cytoplasm in normal human brain tissue using proteinase K and formic acid pretreatment
    Fumiaki Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Japan
    Exp Neurol 176:98-104. 2002
    ..These findings suggest that a significant amount of alphaS is also present in the neuronal and glial cytoplasm in the normal human brain...
  13. ncbi request reprint Pick's disease: alpha- and beta-synuclein-immunoreactive Pick bodies in the dentate gyrus
    Fumiaki Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Acta Neuropathol 104:455-61. 2002
    ....
  14. ncbi request reprint Thalamic retrograde degeneration in the congenitally hydrocephalic rat is attributable to apoptotic cell death
    Fumiaki Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Japan
    Neuropathology 22:186-93. 2002
    ....
  15. ncbi request reprint Alpha-synuclein accumulates in Purkinje cells in Lewy body disease but not in multiple system atrophy
    Fumiaki Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    J Neuropathol Exp Neurol 62:812-9. 2003
    ..No such inclusions were observed in MSA, tauopathies, or controls. These findings indicate that Purkinje cells are also the victims of a-synuclein pathology in PD and DLB, but not in MSA...
  16. ncbi request reprint Reciprocal accumulation of beta-synuclein in alpha-synuclein lesions in multiple system atrophy
    Fumiaki Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Neuroreport 14:1783-6. 2003
    ..Thus, neuronal alpha-synuclein inclusions appear to occur only rarely in neurons in which beta-synuclein accumulates. These findings support the possibility that beta-synuclein is a negative regulator of alpha-synuclein aggregation...
  17. ncbi request reprint Accumulation of NEDD8 in neuronal and glial inclusions of neurodegenerative disorders
    F Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki Shi, Aomori 036 8562, Japan
    Neuropathol Appl Neurobiol 31:53-61. 2005
    ..These findings suggest that NEDD8 is involved in the formation of various ubiquitinated inclusions via the ubiquitin-proteasome system...
  18. ncbi request reprint Hydranencephaly with extensive periventricular necrosis and numerous ectopic glioneuronal nests
    Fumiaki Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Neuropathology 24:315-9. 2004
    ..These lesions date later than hydranencephaly. Considering that numerous glioneuronal nests were found in the present case, it is likely that the encephaloclastic process developed toward the end of gestation...
  19. ncbi request reprint Effects of ryanodine receptor activation on neurotransmitter release and neuronal cell death following kainic acid-induced status epilepticus
    Fumiaki Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Epilepsy Res 65:59-70. 2005
    ..These findings suggest that intracellular Ca(2+) release via the RyR might be one of the mechanisms involved in KA-induced neuronal cell death...
  20. ncbi request reprint Hypoglycemic encephalopathy with extensive lesions in the cerebral white matter
    Fumiaki Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Neuropathology 26:147-52. 2006
    ..Since the cerebral blood flow is reported to be decreased during severe hypoglycemia, the present findings suggest that white matter lesions and boundary-zone infarctions may develop primarily in uncomplicated hypoglycemia...
  21. ncbi request reprint alpha-Synuclein pathology in the neostriatum in Parkinson's disease
    Fumiaki Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, 036 8562, Japan
    Acta Neuropathol 115:453-9. 2008
    ..001). These findings suggest that intrinsic neostriatal neurons degenerate through alphaS aggregation during PD progression...
  22. doi request reprint Maturation process of TDP-43-positive neuronal cytoplasmic inclusions in amyotrophic lateral sclerosis with and without dementia
    Fumiaki Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562, Japan
    Acta Neuropathol 116:193-203. 2008
    ..These findings suggest that there are differences in the formation process between skein-like and round inclusions, despite the antigenic and ultrastructural similarities...
  23. doi request reprint Decreased cystatin C immunoreactivity in spinal motor neurons and astrocytes in amyotrophic lateral sclerosis
    Fumiaki Mori
    Department of Neuropathology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    J Neuropathol Exp Neurol 68:1200-6. 2009
    ....
  24. doi request reprint Widespread occurrence of eosinophilic neuronal cytoplasmic inclusions in an asymptomatic adult: a novel ubiquitin-negative filamentous inclusion
    Fumiaki Mori
    Department of Neuropathology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Neuropathology 30:648-53. 2010
    ..This inclusion seems to represent a new type of neuronal cytoplasmic inclusion...
  25. doi request reprint Relationship between Bunina bodies and TDP-43 inclusions in spinal anterior horn in amyotrophic lateral sclerosis
    F Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, Japan
    Neuropathol Appl Neurobiol 36:345-52. 2010
    ..To elucidate the relationship between BBs and TDP-43 inclusions, we examined the spinal cord from 18 patients with ALS...
  26. doi request reprint Incipient intranuclear inclusion body disease in a 78-year-old woman
    Fumiaki Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Neuropathology 31:188-93. 2011
    ..These findings suggest that INIBD may occur in non-demented elderly individuals and that oligodendrocyte is also involved in the disease process of INIBD...
  27. doi request reprint Enhancement of native and phosphorylated TDP-43 immunoreactivity by proteinase K treatment following autoclave heating
    Fumiaki Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki Department of Pathology, Resource Branch for Brain Disease Research CBBR, Brain Research Institute, University of Niigata, Niigata, Japan
    Neuropathology 31:401-4. 2011
    ..This retrieval method is the best of immunohistochemical techniques for demonstrating TDP-43 pathology, especially in the neuropil...
  28. doi request reprint Accumulation of phosphorylated α-synuclein in subpial and periventricular astrocytes in multiple system atrophy of long duration
    Keiko Nakamura
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki
    Neuropathology 36:157-67. 2016
    ..No such structures were found in Lewy body disease or controls. Accumulation of phosphorylated α-synuclein can occur in subpial and periventricular astrocytes in patients with MSA, especially in those with a long disease duration. ..
  29. pmc Synphilin-1-binding protein NUB1 is colocalized with nonfibrillar, proteinase K-resistant α-synuclein in presynapses in Lewy body disease
    Kunikazu Tanji
    Department of Neuropathology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    J Neuropathol Exp Neurol 70:879-89. 2011
    ..Biochemical analyses showed that NUB1 coexists with abnormal α-synuclein in the brain of DLB patients. These findings suggest that NUB1 along with abnormal α-synuclein is involved in the pathogenesis of Lewy body disease...
  30. ncbi request reprint Accumulation of phosphorylated alpha-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy
    Makoto Nishie
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifu cho, 036 8562, Hirosaki, Japan
    Acta Neuropathol 107:292-8. 2004
    ..Thus, the widespread accumulation of phosphorylated alpha-synuclein in both glial and neuronal cells is a pathological feature in patients suffering from MSA...
  31. doi request reprint Abnormal tau deposition in neurons, but not in glial cells in the cerebral tissue surrounding arteriovenous malformation
    Tomoya Kon
    Department of Neuropathology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Neuropathology 32:267-71. 2012
    ..The present findings indicate that abnormal tau deposition can occur in neurons, but not in glial cells, of the affected cerebral cortex surrounding AVM...
  32. doi request reprint G protein-coupled receptor 26 immunoreactivity in intranuclear inclusions associated with polyglutamine and intranuclear inclusion body diseases
    Fumiaki Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki
    Neuropathology 36:50-5. 2016
    ..These findings suggest that GPR26 may have a common role in the formation or degradation of intranuclear inclusions in several neurodegenerative diseases. ..
  33. ncbi request reprint Alpha-synuclein pathology affecting Bergmann glia of the cerebellum in patients with alpha-synucleinopathies
    Yue Shan Piao
    Department of Pathology, Brain Research Institute, Niigata University, 1 757 Asahimachi, 951 8585 Niigata, Japan
    Acta Neuropathol 105:403-9. 2003
    ..These findings indicate that, although not frequently, Bergmann glia of the cerebellum are also the targets of alpha-synuclein pathology in alpha-synucleinopathies such as PD, DLBD and MSA...
  34. ncbi request reprint TDP-43-immunoreactive neuronal and glial inclusions in the neostriatum in amyotrophic lateral sclerosis with and without dementia
    Haixin Zhang
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562, Japan
    Acta Neuropathol 115:115-22. 2008
    ..These findings suggest that the neostriatum is also involved in the disease process of ALS with and without dementia...
  35. doi request reprint Localization of nuclear receptor subfamily 4, group A, member 3 (NR4A3) in Lewy body disease and multiple system atrophy
    Tomoya Kon
    Department of Neuropathology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Neuropathology 35:503-9. 2015
    ..Neuronal and glial inclusions in other neurodegenerative disorders were NR4A3 negative. These findings suggest that accumulation of NR4A3 is specific to α-synucleinopathy. ..
  36. doi request reprint α-Synuclein pathology in the cranial and spinal nerves in Lewy body disease
    Keiko Nakamura
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki
    Neuropathology 36:262-9. 2016
    ..In the dorsal root ganglia, axonal lesions were seldom evident. These findings indicate that α-synuclein pathology in the peripheral nerves is axonal-predominant in LBD, whereas it is restricted to glial cells in MSA. ..
  37. ncbi request reprint Effects of interleukin-1beta on hippocampal glutamate and GABA releases associated with Ca2+-induced Ca2+ releasing systems
    Gang Zhu
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Epilepsy Res 71:107-16. 2006
    ..These results indicate that hyperactivation of IL-1beta leads to imbalance between glutamatergic and GABAergic transmission via toxic overload response of Ca2+ influx and CICR...
  38. ncbi request reprint Immunohistochemical localization of NUB1, a synphilin-1-binding protein, in neurodegenerative disorders
    Kunikazu Tanji
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki 036 8562, Japan
    Acta Neuropathol 114:365-71. 2007
    ..These findings indicate that the abnormal accumulation of NUB1 is specific for alpha-synucleinopathy lesions. However, yeast two-hybrid assay demonstrated that NUB1 did not directly interact with alpha-synuclein...
  39. doi request reprint Hippocampal sclerosis with four-repeat tau-positive round inclusions in the dentate gyrus: a new type of four-repeat tauopathy
    Yasuo Miki
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Acta Neuropathol 117:713-8. 2009
    ..It is likely that this case is a new variant of 4-repeat tauopathy presenting with hippocampal sclerosis...
  40. doi request reprint p62/sequestosome 1 binds to TDP-43 in brains with frontotemporal lobar degeneration with TDP-43 inclusions
    Kunikazu Tanji
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    J Neurosci Res 90:2034-42. 2012
    ..Our results suggest that the interaction of TDP-43 and p62 is disrupted and may participate in the pathogenesis of TDP-43 proteinopathy...
  41. ncbi request reprint Intrauterine methylmercury intoxication. Consequence of the inherent brain lesions and cognitive dysfunction in maturity
    A Kakita
    Department of Pathology, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951 8585, Japan
    Brain Res 877:322-30. 2000
    ..Thus, chronic intrauterine exposure to low-dose MeHg induces a decrease in neuron population in the limbic system, and the offspring have impaired higher brain function...
  42. ncbi request reprint Upregulation of alpha-synuclein by lipopolysaccharide and interleukin-1 in human macrophages
    Kunikazu Tanji
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Pathol Int 52:572-7. 2002
    ..These findings suggest that the function of alpha-synuclein is not exclusive to the nervous system and that alpha-synuclein may play a role in inflammatory processes and immune responses...
  43. ncbi request reprint Relationship among alpha-synuclein accumulation, dopamine synthesis, and neurodegeneration in Parkinson disease substantia nigra
    Fumiaki Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Japan
    J Neuropathol Exp Neurol 65:808-15. 2006
    ..Therefore, the decrease of TH immunoreactivity in pigmented neurons demonstrated here can be considered to represent a cytoprotective mechanism in PD...
  44. ncbi request reprint Listeria monocytogenes induces the expression of retinoic acid-inducible gene-I
    Tadaatsu Imaizumi
    Vascular Biology, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    Microbiol Immunol 50:811-5. 2006
    ..Both heat-killed L. monocytogenes and live L. monocytogenes induced the expression of RIG-I in cultured RAW264.7 murine macrophage-like cells in vitro. RIG-I may also be involved in innate immunity against Listeria infection...
  45. ncbi request reprint Upregulation of vascular endothelial growth factor by heat-killed Listeria monocytogenes in macrophages
    Fuyuki Sato
    Department of Pathology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Biochem Biophys Res Commun 354:608-12. 2007
    ..monocytogenes (L. monocytogenes). VEGF is thought to be involved in inflammatory reactions induced by L. monocytogenes infection...
  46. doi request reprint Rats harboring S284L Chrna4 mutation show attenuation of synaptic and extrasynaptic GABAergic transmission and exhibit the nocturnal frontal lobe epilepsy phenotype
    Gang Zhu
    Department of Neuropsychiatry, Institute of Brain Science, Graduate School of Medicine, Hirosaki University, Hirosaki 036 8562, Japan
    J Neurosci 28:12465-76. 2008
    ..The currently available genetically engineered animal models of epilepsy are limited to mice; thus, our transgenic rats offer another dimension to the epilepsy research field...
  47. pmc TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in the brain of Parkinson's disease and dementia with Lewy bodies
    Kunikazu Tanji
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Neurobiol Dis 38:210-8. 2010
    ..These results suggest that TRIM9 plays an important role in the regulation of neuronal functions and participates in pathological process of Lewy body disease through its ligase activity...
  48. doi request reprint Proteinase K-resistant alpha-synuclein is deposited in presynapses in human Lewy body disease and A53T alpha-synuclein transgenic mice
    Kunikazu Tanji
    Department of Neuropathology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Acta Neuropathol 120:145-54. 2010
    ..Considering that native alpha-synuclein is a soluble protein localized to the presynaptic terminals, our findings suggest that PK-resistant alpha-synuclein may disturb the neurotransmission in alpha-synucleinopathies...
  49. doi request reprint Autophagic adapter protein NBR1 is localized in Lewy bodies and glial cytoplasmic inclusions and is involved in aggregate formation in α-synucleinopathy
    Saori Odagiri
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562, Japan
    Acta Neuropathol 124:173-86. 2012
    ..Immunoblot analysis showed that the level of NBR1 was significantly increased by 2.5-fold in MSA, but not in DLB. These findings suggest that NBR1 is involved in the formation of cytoplasmic inclusions in α-synucleinopathy...
  50. doi request reprint Keap1 is localized in neuronal and glial cytoplasmic inclusions in various neurodegenerative diseases
    Kunikazu Tanji
    Department of Neuropathology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    J Neuropathol Exp Neurol 72:18-28. 2013
    ..Our pathologic and biochemical results suggest a molecular basis for stress response to be involved in the formation of cytoplasmic inclusions observed in several neurodegenerative diseases...
  51. ncbi request reprint Glycogen synthase kinase-3beta phosphorylates synphilin-1 in vitro
    Kunikazu Tanji
    Department of Neuropathology, Hirosaki University School of Medicine, Hirosaki, Japan
    Neuropathology 23:199-202. 2003
    ..Therefore, phosphorylation of synphilin-1 may play an important role in the function of this protein in the brain...
  52. ncbi request reprint Involvement of Ca(2+)-induced Ca2+ releasing system in interleukin-1beta-associated adenosine release
    Gang Zhu
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Eur J Pharmacol 532:246-52. 2006
    ....
  53. doi request reprint Brain expression level and activity of HDAC6 protein in neurodegenerative dementia
    Saori Odagiri
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Biochem Biophys Res Commun 430:394-9. 2013
    ..These findings suggest that the induced level of HDAC6 in the brain is insufficient for manifestation of its activity in FTLD-TDP and MSA...
  54. ncbi request reprint Process of repair in the neuroepithelium of developing rat brain during neurogenesis: chronological and quantitative observation of DNA-replicating cells
    K Oyanagi
    Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Japan
    Brain Res Dev Brain Res 108:229-38. 1998
    ....
  55. ncbi request reprint Distinct pattern of neuronal degeneration in the fetal rat brain induced by consecutive transplacental administration of methylmercury
    A Kakita
    Department of Pathology, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata, Japan
    Brain Res 859:233-9. 2000
    ..This experimental model could be a useful tool for research on the neurotoxicity of MeHg in the human fetal brain...
  56. pmc ErbB1 receptor ligands attenuate the expression of synaptic scaffolding proteins, GRIP1 and SAP97, in developing neocortex
    D Yokomaku
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi dori 1 757, Niigata 951 8585, Japan
    Neuroscience 136:1037-47. 2005
    ..These findings revealed a novel negative activity of ErbB1 receptor ligands that attenuates the expression of the PDZ proteins and inhibits postsynaptic maturation in developing neocortex...
  57. doi request reprint Valosin-containing protein immunoreactivity in tauopathies, synucleinopathies, polyglutamine diseases and intranuclear inclusion body disease
    Fumiaki Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Neuropathology 33:637-44. 2013
    ..These findings suggest that VCP may have common mechanisms in the formation or degradation of cytoplasmic and nuclear inclusions of neurons, but not of glial cells, in several neurodegenerative conditions. ..
  58. ncbi request reprint Interleukin-1 induces tau phosphorylation and morphological changes in cultured human astrocytes
    Kunikazu Tanji
    Department of Molecular Biology, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Neuroreport 14:413-7. 2003
    ..The early tau phosphorylation induced by IL-1alpha might create a plastic environment for morphological changes in astrocytes...
  59. doi request reprint Accumulation of histone deacetylase 6, an aggresome-related protein, is specific to Lewy bodies and glial cytoplasmic inclusions
    Yasuo Miki
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Neuropathology 31:561-8. 2011
    ..These findings suggest that accumulation of HDAC6 is specific to α-synucleinopathy and that both LBs and GCIs may represent cytoprotective responses to sequester toxic proteins...
  60. doi request reprint Immunohistochemical analysis of Marinesco bodies, using antibodies against proteins implicated in the ubiquitin-proteasome system, autophagy and aggresome formation
    Saori Odagiri
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki 036 8562, Japan
    Neuropathology 32:261-6. 2012
    ..These findings suggest that proteins related to ubiquitination, proteasomal degradation and autophagy are involved in the formation or disaggregation of MBs...
  61. doi request reprint The Lewy body in Parkinson's disease and related neurodegenerative disorders
    Koichi Wakabayashi
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Mol Neurobiol 47:495-508. 2013
    ..However, recent studies have indicated that nonfibrillar α-synuclein is cytotoxic and that fibrillar aggregates of α-synuclein (LBs and pale bodies) may represent a cytoprotective mechanism in PD...
  62. ncbi request reprint Accumulation of alpha-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy
    K Wakabayashi
    Brain Disease Research Center, Brain Research Institute, Niigata University, Japan
    Acta Neuropathol 96:445-52. 1998
    ..These findings strongly suggest that the accumulation of NACP is a cytopathological feature common to LB disease and MSA...
  63. ncbi request reprint The cellular and behavioral consequences of interleukin-1 alpha penetration through the blood-brain barrier of neonatal rats: a critical period for efficacy
    M Tohmi
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    Neuroscience 150:234-50. 2007
    ..During early development, therefore, circulating IL-1 alpha efficiently crosses the blood-brain barrier to induce inflammatory reactions in the brain and influences later behavioral traits...
  64. ncbi request reprint Expression of alpha-synuclein, the precursor of non-amyloid beta component of Alzheimer's disease amyloid, in human cerebral blood vessels
    Wakako Tamo
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Neurosci Lett 326:5-8. 2002
    ..alpha-S is normally expressed in vascular cells and may play some physiological role in the vascular wall...
  65. pmc Filamentous aggregations of phosphorylated α-synuclein in Schwann cells (Schwann cell cytoplasmic inclusions) in multiple system atrophy
    Keiko Nakamura
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562, Japan
    Acta Neuropathol Commun 3:29. 2015
    ..We immunohistochemically examined the cranial and spinal nerves, peripheral ganglia and visceral autonomic nervous system of patients with MSA (n = 14) and control subjects (n = 20)...
  66. doi request reprint Spontaneous epileptic seizures in transgenic rats harboring a human ADNFLE missense mutation in the β2-subunit of the nicotinic acetylcholine receptor
    Yuko Shiba
    Department of Neurophysiology, Hirosaki University Graduate School of Medicine, Hirosaki 036 8562, Japan Electronic address
    Neurosci Res 100:46-54. 2015
    ..Thus, the V286L-TG rat model could be a valuable tool for developing novel mechanism-driven treatment strategies for epilepsy and provide a better understanding of ADNFLE. ..
  67. pmc Phosphorylation of serine 349 of p62 in Alzheimer's disease brain
    Kunikazu Tanji
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Acta Neuropathol Commun 2:50. 2014
    ..However, it remains largely unknown whether p62 is phosphorylated in the Keap1-interacting region under neurodegenerative conditions...
  68. ncbi request reprint Oligodendrocytes within astrocytes ("emperipolesis") in the cerebral white matter in hepatic and hypoglycemic encephalopathy
    Makoto Nishie
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Neuropathology 26:62-5. 2006
    ..The present findings suggest that emperipolesis can occur even in chronic metabolic disorders that extensively involve the cerebral white matter...
  69. ncbi request reprint Co-localization of beta-peptide and phosphorylated tau in astrocytes in a patient with corticobasal degeneration
    Koichi Wakabayashi
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Neuropathology 26:66-71. 2006
    ..This phenomenon implies that phagocytosis of Abeta coincides with production of phosphorylated tau in the same reactive astrocytes...
  70. ncbi request reprint The Lewy body in Parkinson's disease: molecules implicated in the formation and degradation of alpha-synuclein aggregates
    Koichi Wakabayashi
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Neuropathology 27:494-506. 2007
    ..Recent studies have suggested that oligomers and protofibrils of alpha-synuclein are cytotoxic, and that LBs may represent a cytoprotective mechanism in PD...
  71. ncbi request reprint Interferon-gamma upregulates retinoic acid-inducible gene-I in human pericardial mesothelial cells
    Masaharu Hatakeyama
    Department of Surgery, Hirosaki University School of Medicine, Hirosaki, Japan
    Acta Cardiol 62:553-7. 2007
    ..We have addressed the expression of RIG-I in pericardial mesothelial cells...
  72. doi request reprint Sporadic amyotrophic lateral sclerosis with pallido-nigro-luysian degeneration: a TDP-43 immunohistochemical study
    Yasuo Miki
    Department of Neuropathology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Neuropathology 30:149-53. 2010
    ....
  73. doi request reprint Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy-Delta(12,14)-prostaglandin J(2)
    Hai Xin Zhang
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Exp Neurol 222:296-303. 2010
    ..These findings suggest that 15d-PGJ(2) is an endogenous modifier of TDP-43 protein in TDP-43 proteinopathy...
  74. doi request reprint Endosomal sorting related protein CHMP2B is localized in Lewy bodies and glial cytoplasmic inclusions in α-synucleinopathy
    Satoshi Tanikawa
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki 036 8562, Japan
    Neurosci Lett 527:16-21. 2012
    ..These findings suggest that endosomal and autophagic pathway is associated with degradation or formation of α-synuclein aggregates in α-synucleinopathy...
  75. doi request reprint ALS-associated protein FIG4 is localized in Pick and Lewy bodies, and also neuronal nuclear inclusions, in polyglutamine and intranuclear inclusion body diseases
    Tomoya Kon
    Department of Neuropathology, Hirosaki University Graduate School of Medicine, Hirosaki
    Neuropathology 34:19-26. 2014
    ..These findings suggest that FIG4 is not incorporated in TDP-43 inclusions and that it may have a common role in the formation or degradation of neuronal cytoplasmic and nuclear inclusions in several neurodegenerative diseases...
  76. doi request reprint Accumulation of the sigma-1 receptor is common to neuronal nuclear inclusions in various neurodegenerative diseases
    Yasuo Miki
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Neuropathology 34:148-58. 2014
    ..Neurodegenerative diseases characterized by neuronal nuclear inclusions might utilize the ER-related degradation machinery as a common pathway for the degradation of aberrant proteins. ..
  77. ncbi request reprint Apolipoprotein E epsilon4 allele and progression of cortical Lewy body pathology in Parkinson's disease
    K Wakabayashi
    Brain Disease Research Center, Brain Research Institute, Niigata University, Japan
    Acta Neuropathol 95:450-4. 1998
    ..It is possible that when PD occurs in individuals with APOE4, concomitantly evolving cortical LB pathology in a proportion of cases results in limbic (transitional) or neocortical-type LB disease...
  78. ncbi request reprint Expression of calbindin D-28k and parvalbumin in cerebral cortical dysgenesis induced by administration of ethylnitrosourea to rats at the stage of neurogenesis
    K Oyanagi
    Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu, Tokyo 183 8526, Japan
    Acta Neuropathol 101:375-82. 2001
    ....
  79. ncbi request reprint Experimentally induced leptomeningeal glioneuronal heterotopia and underlying cortical dysplasia of the lateral limbic area in rats treated transplacentally with methylmercury
    A Kakita
    Department of Pathology, Brain Research Institute, Niigata University, Japan
    J Neuropathol Exp Neurol 60:768-77. 2001
    ..Thus, cerebral LGH would be induced if a developing brain were insulted at the early stage of neurogenesis. accompanied by cortical dysplasia...
  80. ncbi request reprint Neonatal perturbation of neurotrophic signaling results in abnormal sensorimotor gating and social interaction in adults: implication for epidermal growth factor in cognitive development
    T Futamura
    Molecular Neurobiology, Brain Research Institute, Niigata University, Japan
    Mol Psychiatry 8:19-29. 2003
    ....
  81. doi request reprint The phenotype spectrum of Japanese multiple system atrophy
    T Ozawa
    Department of Neurology, Niigata University Brain Research Institute, Niigata, Japan
    J Neurol Neurosurg Psychiatry 81:1253-5. 2010
    ..This study also aimed to compare the pathological spectrum of Japanese MSA patients with the previously reported results in British MSA patients...
  82. doi request reprint Clinical availability of skin biopsy in the diagnosis of Parkinson's disease
    Yasuo Miki
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki 036 8562, Japan
    Neurosci Lett 469:357-9. 2010
    ..The skin remains to be a promising tissue to be examined for the premortem diagnosis of PD...
  83. doi request reprint Retinoic acid-inducible gene-I is induced by interferon-gamma and regulates CXCL11 expression in HeLa cells
    Ei Yuzawa
    Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562, Japan
    Life Sci 82:670-5. 2008
    ..Immunohistochemical studies revealed the RIG-I expression in the normal human endometrium, suggesting a possible role of RIG-I in human reproductive organs...
  84. doi request reprint Dysfunction of extrasynaptic GABAergic transmission in phospholipase C-related, but catalytically inactive protein 1 knockout mice is associated with an epilepsy phenotype
    Gang Zhu
    Department of Neuropsychiatry, Institute of Brain Science, Hirosaki University, Hirosaki, Japan
    J Pharmacol Exp Ther 340:520-8. 2012
    ..Consequently, the effect of DZP on PRIP-1 knockout mice was reduced. Dysfunction of extrasynaptic GABAergic transmission probably is involved in the epileptic phenotype of PRIP-1 knockout mice...
  85. doi request reprint Transient exposure of neonatal mice to neuregulin-1 results in hyperdopaminergic states in adulthood: implication in neurodevelopmental hypothesis for schizophrenia
    T Kato
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    Mol Psychiatry 16:307-20. 2011
    ..Collectively, our findings provide novel insights into neurotrophic contribution of NRG1 to dopaminergic maldevelopment and schizophrenia pathogenesis...
  86. pmc Beta-synuclein gene alterations in dementia with Lewy bodies
    H Ohtake
    Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan
    Neurology 63:805-11. 2004
    ..To determine whether mutations in the genes for alpha-synuclein or beta-synuclein are responsible for dementia with Lewy bodies (DLB), a disorder closely related to Parkinson disease (PD)...
  87. ncbi request reprint Abnormal expression of epidermal growth factor and its receptor in the forebrain and serum of schizophrenic patients
    T Futamura
    Molecular Neurobiology, Brain Research Institute, Niigata University, Japan
    Mol Psychiatry 7:673-82. 2002
    ....
  88. doi request reprint Co-occurrence of argyrophilic grain disease in sporadic amyotrophic lateral sclerosis
    K Soma
    Department of Pathology, Center for Bioresources, Brain Research Institute, University of Niigata, Niigata, Japan
    Neuropathol Appl Neurobiol 38:54-60. 2012
    ..To elucidate the association of ALS with AGD, we examined the brains from 37 consecutively autopsied patients with sporadic ALS (age range 45-84 years, mean 71.5 ± 9.0 years)...
  89. ncbi request reprint Hereditary dentatorubral-pallidoluysian atrophy: detection of widespread ubiquitinated neuronal and glial intranuclear inclusions in the brain
    Y Hayashi
    Department of Pathology, Brain Research Institute, Niigata University, Japan
    Acta Neuropathol 96:547-52. 1998
    ....
  90. ncbi request reprint Patients with temporal lobe epilepsy show an increase in brain-derived neurotrophic factor protein and its correlation with neuropeptide Y
    M Takahashi
    Division of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    Brain Res 818:579-82. 1999
    ..Thus, these results indicate the activity-dependent expression of BDNF in human subjects and its potential contribution to the pathophysiology of human epilepsy via neuropeptide Y...
  91. ncbi request reprint Ubiquitinated neuronal inclusions in the neostriatum in patients with amyotrophic lateral sclerosis with and without dementia--a study of 60 patients 31 to 87 years of age
    K Wakabayashi
    Brain Disease Research Center, Niigata University, Japan
    Clin Neuropathol 20:47-52. 2001
    ..Recently, similar inclusions were reported to occur in the neostriatum in a case of ALS-D. We, therefore, immunohistochemically examined the neostriatum from 60 patients with ALS and 60 control subjects...
  92. doi request reprint Progression of paralysis is the most useful factor for differentiating malignant from benign intramedullary tumors
    T Ito
    Department of Orthopaedic Surgery, Niigata City General Hospital, Niigata, Japan
    Spinal Cord 51:319-21. 2013
    ..Retrospective study...
  93. doi request reprint Pathologic and immunologic profiles of a limited form of neuromyelitis optica with myelitis
    K Yanagawa
    Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan
    Neurology 73:1628-37. 2009
    ..However, the detailed clinicopathologic features and long-term course of this limited form remain elusive...
  94. ncbi request reprint Aprosencephaly: histopathological features of the rudimentary forebrain and retina
    A Kakita
    Department of Pathology, Brain Research Institute, Niigata University, Japan
    Acta Neuropathol 102:110-6. 2001
    ..This case seems to represent a primary malformation, and the features imply that the failure occurs after neurulation and before the prosencephalic medium began its growth...
  95. ncbi request reprint A quantitative study on the expression of synapsin II and N-ethylmaleimide-sensitive fusion protein in schizophrenic patients
    C Imai
    Molecular Neurobiology, Brain Research Institute, Niigata University, 951 8585, Niigata, Japan
    Neurosci Lett 305:185-8. 2001
    ..These observations suggest that the neurochemical impairments of synapses reported in schizophrenia are not evident for all presynaptic markers and needs to be re-evaluated at molecular levels...
  96. ncbi request reprint Cerebellar cortical tau pathology in progressive supranuclear palsy and corticobasal degeneration
    Yue Shan Piao
    Department of Pathology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata 951 8585, Japan
    Acta Neuropathol 103:469-74. 2002
    ..In conclusion, we have demonstrated a novel tau pathology that affects Purkinje cells and Bergmann's glia in patients with PSP and CBD, indicating that the cerebellar cortex can be involved in the disease processes in PSP and CBD...
  97. ncbi request reprint Neuronal migration disturbance and consequent cytoarchitecture in the cerebral cortex following transplacental administration of methylmercury
    Akiyoshi Kakita
    The Brain Disease Research Center, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951 8585, Japan
    Acta Neuropathol 104:409-17. 2002
    ..These results suggest that it is the extrinsic circumstances - rather than the timing of neuron generation - that regulates the expression of these proteins...
  98. ncbi request reprint Evaluation of changes in methylmercury accumulation in the developing rat brain and its effects: a study with consecutive and moderate dose exposure throughout gestation and lactation periods
    Mineshi Sakamoto
    Department of Epidemiology, National Institute for Minamata Disease, 4058 18 Hama, Minamata, Kumamoto 867 0008, Japan
    Brain Res 949:51-9. 2002
    ..Thus, although offspring are subjected to consecutive and moderate dose MeHg exposure throughout both the gestation and suckling periods, the risk is especially high during gestation but may decrease during lactation...
  99. ncbi request reprint Selective reduction of a PDZ protein, SAP-97, in the prefrontal cortex of patients with chronic schizophrenia
    Kazuhiko Toyooka
    Molecular Neurobiology, Brain Research Institute, Niigata University, Japan
    J Neurochem 83:797-806. 2002
    ..In addition, neuroleptic treatment failed to mimic the SAP97 change. These findings suggest that a phenotypic loss of SAP97 is associated with the postsynaptic impairment in prefrontal excitatory circuits of schizophrenic patients...
  100. ncbi request reprint Neuropathology with clinical correlations of sporadic amyotrophic lateral sclerosis: 102 autopsy cases examined between 1962 and 2000
    Yue Shan Piao
    Department of Pathology, Brain Research Institute, Niigata University, Japan
    Brain Pathol 13:10-22. 2003
    ..The present findings may be helpful for designing further studies on the mechanisms underlying the development of ALS...
  101. ncbi request reprint Some glial progenitors in the neonatal subventricular zone migrate through the corpus callosum to the contralateral cerebral hemisphere
    Akiyoshi Kakita
    Department of Pathology, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Comp Neurol 458:381-8. 2003
    ..Thus, glial progenitors migrate across the CC, presumably in conjunction with unmyelinated axons, to colonize the contralateral hemisphere...