Fumiaki Mori

Summary

Affiliation: Hirosaki University School of Medicine
Country: Japan

Publications

  1. Mori F, Tanji K, Zhang H, Nishihira Y, Tan C, Takahashi H, et al. Maturation process of TDP-43-positive neuronal cytoplasmic inclusions in amyotrophic lateral sclerosis with and without dementia. Acta Neuropathol. 2008;116:193-203 pubmed publisher
    ..These findings suggest that there are differences in the formation process between skein-like and round inclusions, despite the antigenic and ultrastructural similarities. ..
  2. Mori F, Tanji K, Odagiri S, Toyoshima Y, Yoshida M, Ikeda T, et al. Ubiquilin immunoreactivity in cytoplasmic and nuclear inclusions in synucleinopathies, polyglutamine diseases and intranuclear inclusion body disease. Acta Neuropathol. 2012;124:149-51 pubmed publisher
  3. Wakabayashi K, Mori F, Kakita A, Takahashi H, Utsumi J, Sasaki H. Analysis of microRNA from archived formalin-fixed paraffin-embedded specimens of amyotrophic lateral sclerosis. Acta Neuropathol Commun. 2014;2:173 pubmed publisher
    ..Although analysis was possible for just under half of the specimens examined, we were able to show that informative miRNA data can be derived from archived FFPE samples from postmortem cases of neurodegenerative disorders. ..
  4. request reprint
    Mori F, Fukaya M, Abe H, Wakabayashi K, Watanabe M. Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain. Neurosci Lett. 2000;285:57-60 pubmed
    ..Therefore, RyR expression undergoes dynamic changes during the early postnatal period, when neurons are undergoing structural and functional differentiation. ..
  5. request reprint
    Mori F, Hayashi S, Yamagishi S, Yoshimoto M, Yagihashi S, Takahashi H, et al. Pick's disease: alpha- and beta-synuclein-immunoreactive Pick bodies in the dentate gyrus. Acta Neuropathol. 2002;104:455-61 pubmed
    ....
  6. request reprint
    Mori F, Tanji K, Yoshida Y, Wakabayashi K. Thalamic retrograde degeneration in the congenitally hydrocephalic rat is attributable to apoptotic cell death. Neuropathology. 2002;22:186-93 pubmed
    ....
  7. request reprint
    Mori F, Nishie M, Tanno K, Sannohe S, Kuroda N, Wakabayashi K. Hydranencephaly with extensive periventricular necrosis and numerous ectopic glioneuronal nests. Neuropathology. 2004;24:315-9 pubmed
    ..These lesions date later than hydranencephaly. Considering that numerous glioneuronal nests were found in the present case, it is likely that the encephaloclastic process developed toward the end of gestation...
  8. Mori F, Tanji K, Miki Y, Wakabayashi K. Decreased cystatin C immunoreactivity in spinal motor neurons and astrocytes in amyotrophic lateral sclerosis. J Neuropathol Exp Neurol. 2009;68:1200-6 pubmed publisher
    ....
  9. Mori F, Tanji K, Odagiri S, Hattori M, Hoshikawa Y, Kono C, et al. Ubiquitin-related proteins in neuronal and glial intranuclear inclusions in intranuclear inclusion body disease. Pathol Int. 2012;62:407-11 pubmed publisher
    ..05). These findings suggest that proteins related to ubiquitination and proteasomal degradation are involved in the formation of INI in INIBD. ..
  10. Mori F, Tanji K, Odagiri S, Toyoshima Y, Yoshida M, Kakita A, et al. Autophagy-related proteins (p62, NBR1 and LC3) in intranuclear inclusions in neurodegenerative diseases. Neurosci Lett. 2012;522:134-8 pubmed publisher
    ..2%), DRPLA (5.5%) and INIBD (13.2%) and negative for LC3 in MJD, DRPLA and INIBD, except for one case of INIBD. These findings suggest that autophagy-lysosome pathway is not involved in the formation/degradation of NIIs. ..

Locale

Detail Information

Publications10

  1. Mori F, Tanji K, Zhang H, Nishihira Y, Tan C, Takahashi H, et al. Maturation process of TDP-43-positive neuronal cytoplasmic inclusions in amyotrophic lateral sclerosis with and without dementia. Acta Neuropathol. 2008;116:193-203 pubmed publisher
    ..These findings suggest that there are differences in the formation process between skein-like and round inclusions, despite the antigenic and ultrastructural similarities. ..
  2. Mori F, Tanji K, Odagiri S, Toyoshima Y, Yoshida M, Ikeda T, et al. Ubiquilin immunoreactivity in cytoplasmic and nuclear inclusions in synucleinopathies, polyglutamine diseases and intranuclear inclusion body disease. Acta Neuropathol. 2012;124:149-51 pubmed publisher
  3. Wakabayashi K, Mori F, Kakita A, Takahashi H, Utsumi J, Sasaki H. Analysis of microRNA from archived formalin-fixed paraffin-embedded specimens of amyotrophic lateral sclerosis. Acta Neuropathol Commun. 2014;2:173 pubmed publisher
    ..Although analysis was possible for just under half of the specimens examined, we were able to show that informative miRNA data can be derived from archived FFPE samples from postmortem cases of neurodegenerative disorders. ..
  4. request reprint
    Mori F, Fukaya M, Abe H, Wakabayashi K, Watanabe M. Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain. Neurosci Lett. 2000;285:57-60 pubmed
    ..Therefore, RyR expression undergoes dynamic changes during the early postnatal period, when neurons are undergoing structural and functional differentiation. ..
  5. request reprint
    Mori F, Hayashi S, Yamagishi S, Yoshimoto M, Yagihashi S, Takahashi H, et al. Pick's disease: alpha- and beta-synuclein-immunoreactive Pick bodies in the dentate gyrus. Acta Neuropathol. 2002;104:455-61 pubmed
    ....
  6. request reprint
    Mori F, Tanji K, Yoshida Y, Wakabayashi K. Thalamic retrograde degeneration in the congenitally hydrocephalic rat is attributable to apoptotic cell death. Neuropathology. 2002;22:186-93 pubmed
    ....
  7. request reprint
    Mori F, Nishie M, Tanno K, Sannohe S, Kuroda N, Wakabayashi K. Hydranencephaly with extensive periventricular necrosis and numerous ectopic glioneuronal nests. Neuropathology. 2004;24:315-9 pubmed
    ..These lesions date later than hydranencephaly. Considering that numerous glioneuronal nests were found in the present case, it is likely that the encephaloclastic process developed toward the end of gestation...
  8. Mori F, Tanji K, Miki Y, Wakabayashi K. Decreased cystatin C immunoreactivity in spinal motor neurons and astrocytes in amyotrophic lateral sclerosis. J Neuropathol Exp Neurol. 2009;68:1200-6 pubmed publisher
    ....
  9. Mori F, Tanji K, Odagiri S, Hattori M, Hoshikawa Y, Kono C, et al. Ubiquitin-related proteins in neuronal and glial intranuclear inclusions in intranuclear inclusion body disease. Pathol Int. 2012;62:407-11 pubmed publisher
    ..05). These findings suggest that proteins related to ubiquitination and proteasomal degradation are involved in the formation of INI in INIBD. ..
  10. Mori F, Tanji K, Odagiri S, Toyoshima Y, Yoshida M, Kakita A, et al. Autophagy-related proteins (p62, NBR1 and LC3) in intranuclear inclusions in neurodegenerative diseases. Neurosci Lett. 2012;522:134-8 pubmed publisher
    ..2%), DRPLA (5.5%) and INIBD (13.2%) and negative for LC3 in MJD, DRPLA and INIBD, except for one case of INIBD. These findings suggest that autophagy-lysosome pathway is not involved in the formation/degradation of NIIs. ..