Fumiaki Mori


Affiliation: Hirosaki University School of Medicine
Country: Japan


  1. request reprint
    Mori F, Okada M, Tomiyama M, Kaneko S, Wakabayashi K. Effects of ryanodine receptor activation on neurotransmitter release and neuronal cell death following kainic acid-induced status epilepticus. Epilepsy Res. 2005;65:59-70 pubmed
    ..These findings suggest that intracellular Ca(2+) release via the RyR might be one of the mechanisms involved in KA-induced neuronal cell death. ..
  2. Mori F, Tanji K, Kon T, Odagiri S, Hattori M, Hoshikawa Y, et al. FUS immunoreactivity of neuronal and glial intranuclear inclusions in intranuclear inclusion body disease. Neuropathol Appl Neurobiol. 2012;38:322-8 pubmed publisher
    ..These findings suggest that FUS is incorporated into INIBs in both neurones and glial cells and that loss of normal FUS immunoreactivity may result from reduced protein expression and/or sequestration within inclusions. ..
  3. request reprint
    Mori F, Tanji K, Wakabayashi K. Widespread calcium deposits, as detected using the alizarin red S technique, in the nervous system of rats treated with dimethyl mercury. Neuropathology. 2000;20:210-5 pubmed
    ..These findings suggest that widespread calcium deposition could occur in the nervous system following dimethyl mercury exposure, and that in the rat the mechanism of calcium deposition differs depending upon the brain region. ..
  4. request reprint
    Mori F, Inenaga C, Yoshimoto M, Umezu H, Tanaka R, Takahashi H, et al. Alpha-synuclein immunoreactivity in normal and neoplastic Schwann cells. Acta Neuropathol. 2002;103:145-51 pubmed
    ..No beta- or gamma-synuclein immunoreactivity was found in those cells. These results indicate that in the PNS, alpha-synuclein is a useful marker of Schwann cells and that it is not involved in tumorigenesis. ..
  5. Mori F, Miki Y, Tanji K, Kusumi T, Kijima H, Wakabayashi K. Widespread occurrence of eosinophilic neuronal cytoplasmic inclusions in an asymptomatic adult: a novel ubiquitin-negative filamentous inclusion. Neuropathology. 2010;30:648-53 pubmed publisher
    ..This inclusion seems to represent a new type of neuronal cytoplasmic inclusion. ..
  6. request reprint
    Mori F, Tanji K, Wakabayashi K. Thiophene, a sulfur-containing heterocyclic hydrocarbon, causes widespread neuronal degeneration in rats. Neuropathology. 2000;20:283-8 pubmed
    ..These findings suggest that thiophene causes widespread neuronal degeneration in rats and that the regional distribution of brain lesions induced by thiophene is different from that caused by methyl mercury poisoning. ..
  7. request reprint
    Mori F, Nishie M, Piao Y, Kito K, Kamitani T, Takahashi H, et al. Accumulation of NEDD8 in neuronal and glial inclusions of neurodegenerative disorders. Neuropathol Appl Neurobiol. 2005;31:53-61 pubmed
    ..These findings suggest that NEDD8 is involved in the formation of various ubiquitinated inclusions via the ubiquitin-proteasome system. ..
  8. Mori F, Tanji K, Kakita A, Takahashi H, Wakabayashi K. Enhancement of native and phosphorylated TDP-43 immunoreactivity by proteinase K treatment following autoclave heating. Neuropathology. 2011;31:401-4 pubmed publisher
    ..This retrieval method is the best of immunohistochemical techniques for demonstrating TDP-43 pathology, especially in the neuropil. ..
  9. Mori F, Miki Y, Tanji K, Ogura E, Yagihashi N, Jensen P, et al. Incipient intranuclear inclusion body disease in a 78-year-old woman. Neuropathology. 2011;31:188-93 pubmed publisher
    ..These findings suggest that INIBD may occur in non-demented elderly individuals and that oligodendrocyte is also involved in the disease process of INIBD. ..

More Information


  1. Mori F, Tanji K, Miki Y, Kakita A, Takahashi H, Wakabayashi K. Relationship between Bunina bodies and TDP-43 inclusions in spinal anterior horn in amyotrophic lateral sclerosis. Neuropathol Appl Neurobiol. 2010;36:345-52 pubmed publisher
    ..These findings suggest that there is a close relationship in the occurrence between BBs and TDP-43 inclusions. ..
  2. Wakabayashi K, Mori F, Kakita A, Takahashi H, Utsumi J, Sasaki H. Analysis of microRNA from archived formalin-fixed paraffin-embedded specimens of amyotrophic lateral sclerosis. Acta Neuropathol Commun. 2014;2:173 pubmed publisher
    ..Although analysis was possible for just under half of the specimens examined, we were able to show that informative miRNA data can be derived from archived FFPE samples from postmortem cases of neurodegenerative disorders. ..
  3. Mori F, Tanji K, Odagiri S, Toyoshima Y, Yoshida M, Ikeda T, et al. Ubiquilin immunoreactivity in cytoplasmic and nuclear inclusions in synucleinopathies, polyglutamine diseases and intranuclear inclusion body disease. Acta Neuropathol. 2012;124:149-51 pubmed publisher
  4. Mori F, Tanji K, Zhang H, Nishihira Y, Tan C, Takahashi H, et al. Maturation process of TDP-43-positive neuronal cytoplasmic inclusions in amyotrophic lateral sclerosis with and without dementia. Acta Neuropathol. 2008;116:193-203 pubmed publisher
    ..These findings suggest that there are differences in the formation process between skein-like and round inclusions, despite the antigenic and ultrastructural similarities. ..
  5. Mori F, Tanji K, Miki Y, Wakabayashi K. Decreased cystatin C immunoreactivity in spinal motor neurons and astrocytes in amyotrophic lateral sclerosis. J Neuropathol Exp Neurol. 2009;68:1200-6 pubmed publisher
  6. request reprint
    Mori F, Nishie M, Tanno K, Sannohe S, Kuroda N, Wakabayashi K. Hydranencephaly with extensive periventricular necrosis and numerous ectopic glioneuronal nests. Neuropathology. 2004;24:315-9 pubmed
    ..These lesions date later than hydranencephaly. Considering that numerous glioneuronal nests were found in the present case, it is likely that the encephaloclastic process developed toward the end of gestation...
  7. request reprint
    Mori F, Tanji K, Yoshida Y, Wakabayashi K. Thalamic retrograde degeneration in the congenitally hydrocephalic rat is attributable to apoptotic cell death. Neuropathology. 2002;22:186-93 pubmed
  8. Mori F, Tanji K, Odagiri S, Hattori M, Hoshikawa Y, Kono C, et al. Ubiquitin-related proteins in neuronal and glial intranuclear inclusions in intranuclear inclusion body disease. Pathol Int. 2012;62:407-11 pubmed publisher
    ..05). These findings suggest that proteins related to ubiquitination and proteasomal degradation are involved in the formation of INI in INIBD. ..
  9. request reprint
    Mori F, Hayashi S, Yamagishi S, Yoshimoto M, Yagihashi S, Takahashi H, et al. Pick's disease: alpha- and beta-synuclein-immunoreactive Pick bodies in the dentate gyrus. Acta Neuropathol. 2002;104:455-61 pubmed
  10. Mori F, Tanji K, Odagiri S, Toyoshima Y, Yoshida M, Kakita A, et al. Autophagy-related proteins (p62, NBR1 and LC3) in intranuclear inclusions in neurodegenerative diseases. Neurosci Lett. 2012;522:134-8 pubmed publisher
    ..2%), DRPLA (5.5%) and INIBD (13.2%) and negative for LC3 in MJD, DRPLA and INIBD, except for one case of INIBD. These findings suggest that autophagy-lysosome pathway is not involved in the formation/degradation of NIIs. ..
  11. request reprint
    Mori F, Fukaya M, Abe H, Wakabayashi K, Watanabe M. Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain. Neurosci Lett. 2000;285:57-60 pubmed
    ..Therefore, RyR expression undergoes dynamic changes during the early postnatal period, when neurons are undergoing structural and functional differentiation. ..