Tadaatsu Imaizumi

Summary

Affiliation: Hirosaki University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint Listeria monocytogenes induces the expression of retinoic acid-inducible gene-I
    Tadaatsu Imaizumi
    Vascular Biology, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    Microbiol Immunol 50:811-5. 2006
  2. pmc Involvement of retinoic acid-inducible gene-I in inflammation of rheumatoid fibroblast-like synoviocytes
    T Imaizumi
    Departments of Vascular Biology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Clin Exp Immunol 153:240-4. 2008
  3. doi request reprint MDA5 and ISG56 mediate CXCL10 expression induced by toll-like receptor 4 activation in U373MG human astrocytoma cells
    Tadaatsu Imaizumi
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Neurosci Res 76:195-206. 2013
  4. doi request reprint Interaction between interferon-stimulated gene 56 and melanoma differentiation-associated gene 5 in Toll-like receptor 3 signaling in normal human mesangial cells
    Tadaatsu Imaizumi
    Department of Vascular Biology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Am J Nephrol 37:118-25. 2013
  5. ncbi request reprint Melanoma differentiation-associated gene 5 regulates the expression of a chemokine CXCL10 in human mesangial cells: implications for chronic inflammatory renal diseases
    Tadaatsu Imaizumi
    Department of Vascular Biology, Hirosaki University Graduate School of Medicine, Hirosaki 036 8562, Japan
    Tohoku J Exp Med 228:17-26. 2012
  6. ncbi request reprint 15-deoxy-delta(12,14)-prostaglandin J2 inhibits IFN-gamma-induced galectin-9 expression in cultured human umbilical vein endothelial cells
    Tadaatsu Imaizumi
    Department of Vascular Biology, Hirosaki University School of Medicine, Hirosaki, Japan
    Int Arch Allergy Immunol 131:57-61. 2003
  7. ncbi request reprint Effect of double-stranded RNA on the expression of epithelial neutrophil activating peptide-78/CXCL-5 in human endothelial cells
    Tadaatsu Imaizumi
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Inflammation 28:215-9. 2004
  8. ncbi request reprint Interferon-gamma induces retinoic acid-inducible gene-I in endothelial cells
    T Imaizumi
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Endothelium 11:169-73. 2004
  9. ncbi request reprint Upregulation of retinoic acid-inducible gene-I in T24 urinary bladder carcinoma cells stimulated with interferon-gamma
    Tadaatsu Imaizumi
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Zaifu cho, Japan
    Tohoku J Exp Med 203:313-8. 2004
  10. ncbi request reprint Expression of retinoic acid-inducible gene-I in vascular smooth muscle cells stimulated with interferon-gamma
    Tadaatsu Imaizumi
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Life Sci 75:1171-80. 2004

Collaborators

Detail Information

Publications101 found, 100 shown here

  1. ncbi request reprint Listeria monocytogenes induces the expression of retinoic acid-inducible gene-I
    Tadaatsu Imaizumi
    Vascular Biology, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    Microbiol Immunol 50:811-5. 2006
    ..Both heat-killed L. monocytogenes and live L. monocytogenes induced the expression of RIG-I in cultured RAW264.7 murine macrophage-like cells in vitro. RIG-I may also be involved in innate immunity against Listeria infection...
  2. pmc Involvement of retinoic acid-inducible gene-I in inflammation of rheumatoid fibroblast-like synoviocytes
    T Imaizumi
    Departments of Vascular Biology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Clin Exp Immunol 153:240-4. 2008
    ..These findings suggest that RIG-I may play an important role in the pathogenesis of synovial inflammation in RA, at least in part, by regulating the IFN-gamma-induced expression of CXCL10/IP-10...
  3. doi request reprint MDA5 and ISG56 mediate CXCL10 expression induced by toll-like receptor 4 activation in U373MG human astrocytoma cells
    Tadaatsu Imaizumi
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Neurosci Res 76:195-206. 2013
    ....
  4. doi request reprint Interaction between interferon-stimulated gene 56 and melanoma differentiation-associated gene 5 in Toll-like receptor 3 signaling in normal human mesangial cells
    Tadaatsu Imaizumi
    Department of Vascular Biology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Am J Nephrol 37:118-25. 2013
    ....
  5. ncbi request reprint Melanoma differentiation-associated gene 5 regulates the expression of a chemokine CXCL10 in human mesangial cells: implications for chronic inflammatory renal diseases
    Tadaatsu Imaizumi
    Department of Vascular Biology, Hirosaki University Graduate School of Medicine, Hirosaki 036 8562, Japan
    Tohoku J Exp Med 228:17-26. 2012
    ..MDA5 may be involved not only in physiological antiviral reactions but also in chronic inflammation in glomerular mesangial cells...
  6. ncbi request reprint 15-deoxy-delta(12,14)-prostaglandin J2 inhibits IFN-gamma-induced galectin-9 expression in cultured human umbilical vein endothelial cells
    Tadaatsu Imaizumi
    Department of Vascular Biology, Hirosaki University School of Medicine, Hirosaki, Japan
    Int Arch Allergy Immunol 131:57-61. 2003
    ..15-deoxy-delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) is a ligand for peroxisome proliferator-activated receptor-gamma (PPAR-gamma), and known to modulate the expression of various genes...
  7. ncbi request reprint Effect of double-stranded RNA on the expression of epithelial neutrophil activating peptide-78/CXCL-5 in human endothelial cells
    Tadaatsu Imaizumi
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Inflammation 28:215-9. 2004
    ..2-Aminopurine, an inhibitor of dsRNA-dependent kinase, suppressed the induction of ENA-78 by poly IC. ENA-78 may be involved in the inflammatory reactions elicited by viral infection in endothelial cells...
  8. ncbi request reprint Interferon-gamma induces retinoic acid-inducible gene-I in endothelial cells
    T Imaizumi
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Endothelium 11:169-73. 2004
    ..Although the physiological function of RIG-I is still unknown, induction of RIG-I by IFN-gamma may play an important role in inflammatory or immunological reactions in endothelial cells...
  9. ncbi request reprint Upregulation of retinoic acid-inducible gene-I in T24 urinary bladder carcinoma cells stimulated with interferon-gamma
    Tadaatsu Imaizumi
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Zaifu cho, Japan
    Tohoku J Exp Med 203:313-8. 2004
    ..We conclude that RIG-I may play some role in inflammatory reactions in the urinary tract epithelium...
  10. ncbi request reprint Expression of retinoic acid-inducible gene-I in vascular smooth muscle cells stimulated with interferon-gamma
    Tadaatsu Imaizumi
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Life Sci 75:1171-80. 2004
    ..Immunohistochemical analysis revealed the expression of RIG-I in SMC in vivo. We conclude that RIG-I may play some pathophysiological role in immune and inflammatory reactions in SMC...
  11. ncbi request reprint Regulation of CX3CL1/fractalkine expression in endothelial cells
    Tadaatsu Imaizumi
    Department of Vascular Biology, Hirosaki University School of Medicine, Aomori, Japan
    J Atheroscler Thromb 11:15-21. 2004
    ..The expression of fractalkine is tightly regulated and fractalkine plays an important role in the interaction between leukocytes and endothelial cells...
  12. ncbi request reprint Effect of 15-deoxy-delta12,14-prostaglandin J2 on IL-1beta-induced expression of epithelial neutrophil-activating protein-78 in human endothelial cells
    Tadaatsu Imaizumi
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Prostaglandins Leukot Essent Fatty Acids 69:323-7. 2003
    ..15d-PGJ(2) may modulate inflammatory reactions by regulating the balance of CXC chemokines in endothelial cells...
  13. ncbi request reprint 15-Deoxy-delta 12,14-prostaglandin J2 inhibits the expression of granulocyte-macrophage colony-stimulating factor in endothelial cells stimulated with lipopolysaccharide
    Tadaatsu Imaizumi
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 4562, Japan
    Prostaglandins Other Lipid Mediat 71:293-9. 2003
    ..15d-PGJ2 induced, by itself, the expression of interleukin-8, a potent proinflammatory chemokine, in HUVEC. 15d-PGJ2 may regulate inflammatory reactions by controlling the balance of various cytokines...
  14. ncbi request reprint Involvement of retinoic acid-inducible gene-I in the IFN-{gamma}/STAT1 signalling pathway in BEAS-2B cells
    T Imaizumi
    Dept of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Eur Respir J 25:1077-83. 2005
    ..It is concluded that retinoic acid-inducible gene-I may play an important role in the regulation of immunological reactions in bronchial epithelial cells elicited by interferon-gamma...
  15. ncbi request reprint Effect of peroxisome proliferator-activated receptor-gamma ligands on the expression of retinoic acid-inducible gene-I in endothelial cells stimulated with lipopolysaccharide
    Tadaatsu Imaizumi
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Prostaglandins Other Lipid Mediat 78:46-54. 2005
    ..These results suggest that 15d-PGJ2 inhibits LPS-induced RIG-I expression through a mechanism independent on PPAR-gamma. 15d-PGJ2 may regulate inflammatory reactions, at least in part, by inhibiting the expression of RIG-I...
  16. doi request reprint Polyinosinic-polycytidylic acid induces the expression of interferon-stimulated gene 20 in mesangial cells
    Tadaatsu Imaizumi
    Department of Vascular Biology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Nephron Exp Nephrol 119:e40-8. 2011
    ..The expression and the role of ISG20 in mesangial cells have not been reported...
  17. doi request reprint Basic-helix-loop-helix transcription factor DEC2 constitutes negative feedback loop in IFN-β-mediated inflammatory responses in human mesangial cells
    Tadaatsu Imaizumi
    Department of Vascular Biology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Immunol Lett 136:37-43. 2011
    ..DEC2 expression may constitute a negative feedback system for the IFN-β/RIG-I/CCL5 pathway in the glomerulus, which may play a role in controlling protracted inflammatory reactions in the kidney...
  18. doi request reprint IFN-γ and TNF-α synergistically induce microRNA-155 which regulates TAB2/IP-10 expression in human mesangial cells
    Tadaatsu Imaizumi
    Department of Vascular Biology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Am J Nephrol 32:462-8. 2010
    ..However, the role of miR-155 in inflammatory responses in mesangial cells is not known. In the present study, we examined the expression of miR-155 in mesangial cells...
  19. doi request reprint Tumor-necrosis factor-alpha induces retinoic acid-inducible gene-I in rheumatoid fibroblast-like synoviocytes
    Tadaatsu Imaizumi
    Department of Vascular Biology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Immunol Lett 122:89-93. 2009
    ..These findings suggest that the TNF-alpha/IFN-beta/RIG-I/CCL5 pathway may be involved in the pathogenesis of synovial inflammation in RA...
  20. doi request reprint Expression of interferon-stimulated gene 20 in vascular endothelial cells
    Tadaatsu Imaizumi
    Department of Vascular Biology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Microbiol Immunol 52:30-5. 2008
    ..These results suggest that ISG20 induction by poly IC may not be dependent on the IRF-3-mediated type I IFN induction pathway in HUVEC. ISG20 may be involved in innate immunity against viral infection in vascular endothelial cells...
  21. ncbi request reprint Expression of retinoic acid-inducible gene-I (RIG-I) in macrophages: possible involvement of RIG-I in atherosclerosis
    Tadaatsu Imaizumi
    Department of Vascular Biology, Hirosaki University School of Medicine, Hirosaki, Japan
    J Atheroscler Thromb 14:51-5. 2007
    ..Retinoic acid-inducible gene-I (RIG-I) is one of the genes induced by interferon (IFN)-gamma which plays an important role in atherosclerosis. The aim of this study is to examine if RIG-I is involved in atherosclerosis...
  22. ncbi request reprint Double-stranded RNA induces galectin-9 in vascular endothelial cells: involvement of TLR3, PI3K, and IRF3 pathway
    Tadaatsu Imaizumi
    Department of Vascular Biology, Hirosaki University School of Medicine, Hirosaki, Japan
    Glycobiology 17:12C-5C. 2007
    ..RNAi against interferon regulatory factor 3 (IRF3) also inhibited poly IC-induced galectin-9 expression. We conclude that TLR3, PI3K, and IRF3 are involved in the poly IC-induced galectin-9 expression in HUVECs...
  23. ncbi request reprint 15-Deoxy-D12,14-prostaglandin J2 inhibits CX3CL1/fractalkine expression in human endothelial cells
    Tadaatsu Imaizumi
    Departments of Vascular Biology, Hirosaki University School of Medicine, Japan
    Immunol Cell Biol 80:531-6. 2002
    ..The data suggest that 15d-PGJ2 regulates inflammatoryreactions, at least in part, through the inhibition of fractalkineexpression and leucocyte traffic through the endothelium...
  24. ncbi request reprint Retinoic acid-inducible gene-I is induced in endothelial cells by LPS and regulates expression of COX-2
    Tadaatsu Imaizumi
    Department of Vascular Biology, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Biochem Biophys Res Commun 292:274-9. 2002
    ..RIG-I is an inducible gene in stimulated endothelial cells that may have important roles in vascular pathology by virtue of its ability to regulate expression of the COX-2 gene product...
  25. ncbi request reprint Expression of vascular endothelial growth factor in human umbilical vein endothelial cells stimulated with interleukin-1alpha--an autocrine regulation of angiogenesis and inflammatory reactions
    T Imaizumi
    Department of Pathological Physiology, Institute of Neurological Diseases, Hirosaki University School of Medicine, Japan
    Thromb Haemost 83:949-55. 2000
    ..The growth of HUVEC stimulated with IL-1alpha was inhibited by a neutralizing antibody against VEGF. We conclude that IL-1alpha and VEGF may play an important role in autocrine growth regulation of HUVEC...
  26. ncbi request reprint Interferon-gamma stimulates the expression of CX3CL1/fractalkine in cultured human endothelial cells
    T Imaizumi
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Japan
    Tohoku J Exp Med 192:127-39. 2000
    ..Vascular endothelial cells produce fractalkine in response to IFN-gamma, and this may play an important role in immune responses by eliciting a traffic of mononuclear cells through the vascular wall...
  27. ncbi request reprint Expression of tumor necrosis factor-alpha in cultured human endothelial cells stimulated with lipopolysaccharide or interleukin-1alpha
    T Imaizumi
    Department of Pathological Physiology, Institute of Neurological Diseases, Hirosaki University School of Medicine, Japan
    Arterioscler Thromb Vasc Biol 20:410-5. 2000
    ..Secreted TNF-alpha may be involved in autocrine activation of endothelial cells, and TNF-alpha retained in cell membrane may serve as a juxtacrine system to activate target cells on the endothelial surface...
  28. ncbi request reprint Interferon-gamma stimulates the expression of galectin-9 in cultured human endothelial cells
    Tadaatsu Imaizumi
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Japan
    J Leukoc Biol 72:486-91. 2002
    ..IFN-gamma-induced production of galectin-9 by endothelial cells may play an important role in immune responses by regulating interactions between the vascular wall and eosinophils...
  29. ncbi request reprint Retinoic acid-inducible gene-I mediates RANTES/CCL5 expression in U373MG human astrocytoma cells stimulated with double-stranded RNA
    Hidemi Yoshida
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Neurosci Res 58:199-206. 2007
    ..We conclude that RIG-I may be involved in immune reactions against viral infection, at least in part, through the regulation of RANTES expression in astrocytes...
  30. doi request reprint Edaravone improves the expression of nerve growth factor in human astrocytes subjected to hypoxia/reoxygenation
    Hidemi Yoshida
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Zaifu cho, Hirosaki, Japan
    Neurosci Res 66:284-9. 2010
    ..We conclude that edaravone enhances, via the JNK pathway, NGF expression in astrocytes. This agent may exert a neurotrophic effect in the therapy of brain injury in ischemia/reperfusion...
  31. ncbi request reprint Expression of vascular endothelial growth factor by photodynamic therapy with mono-L-aspartyl chlorin e6 (NPe6) in oral squamous cell carcinoma
    Hiroshi Nakagawa
    Department of Dentistry and Oral Surgery, Hirosaki University School of Medicine, Hirosaki, Japan
    Oral Oncol 43:544-50. 2007
    ..We conclude that Npe6-mediated PDT induces the expression of VEGF, c-jun and c-fos in human oral carcinoma cell line, HSC-3 cell, and at least partly, through the activation of p38 MAPK...
  32. ncbi request reprint Platelet-activating factor enhances the expression of vascular endothelial growth factor in normal human astrocytes
    Hidemi Yoshida
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Brain Res 944:65-72. 2002
    ..We conclude that PAF induces VEGF gene expression in human astrocytes, and the PAF-induced increase in the expression of VEGF may modulate nervous tissue injury due to hypoxia...
  33. ncbi request reprint Effect of MG132, a proteasome inhibitor, on the expression of growth related oncogene protein-alpha in human umbilical vein endothelial cells
    Takeo Shibata
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Cytokine 24:67-73. 2003
    ..We conclude that MG132 upregulates GRO-alpha expression in vascular endothelial cells, at least in part, through the activation of p38 MAPK...
  34. ncbi request reprint Interleukin-1beta enhances the angiotensin-induced expression of plasminogen activator inhibitor-1 through angiotensin receptor upregulation in human astrocytes
    Hidemi Yoshida
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Brain Res 1073:38-47. 2006
    ..We conclude that IL-1beta increases angiotensin II-induced PAI-1 secretion by astrocytes through the induction of AT1, and the enhanced secretion of PAI-1 may modulate functions of plasminogen activators in the nervous system...
  35. ncbi request reprint Double-stranded RNA stimulates the expression of monocyte chemoattractant protein-1 in BEAS-2B bronchial epithelial cells
    Kageaki Taima
    The Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    Exp Lung Res 31:361-75. 2005
    ..The poly IC-induced up-regulation of MCP-1 was blocked by 2-aminopurine, a specific inhibitor of dsRNA-dependent protein kinase, but not by nuclear factor (NF)-kappaB inhibitor SN50...
  36. ncbi request reprint Expression of IP-10/CXCL10 is upregulated by double-stranded RNA in BEAS-2B bronchial epithelial cells
    Kageaki Taima
    Second Department of Internal Medicine, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Respiration 73:360-4. 2006
    ..Polyinosinic-polycytidylic acid (poly IC) is a synthetic double-stranded RNA (dsRNA) and induces antiviral reactions in cells...
  37. ncbi request reprint Effect of hypoxia on the expression of fractalkine in human endothelial cells
    Koji Yamashita
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Tohoku J Exp Med 200:187-94. 2003
    ..Inhibition of fractalkine expression by hypoxia may be involved in the pathophysiology of ischemic diseases...
  38. doi request reprint Glomerular expression of fractalkine is induced by polyinosinic-polycytidylic acid in human mesangial cells: possible involvement of fractalkine after viral infection
    Tomomi Aizawa-Yashiro
    Department of Pediatrics, Hirosaki University Hospital, Hirosaki, Japan
    Pediatr Res 73:180-6. 2013
    ..To examine the involvement of glomerular Fkn expression in the development of glomerulonephritis after viral infection, we conducted experimental studies using human mesangial cells (MCs) in culture...
  39. ncbi request reprint Polyinosinic-polycytidylic acid induces the expression of GRO-alpha in BEAS-2B cells
    Koji Yamashita
    Department of Vascular Biology, Institute of Brain Science, University School of Medicine, Hirosaki, Japan
    Inflammation 29:17-21. 2005
    ..Airway viral infection may elicit GRO-alpha expression in the bronchial epithelium, which may be implicated in inflammatory and immune reactions...
  40. ncbi request reprint Platelet-activating factor enhances the expression of nerve growth factor in normal human astrocytes under hypoxia
    Hidemi Yoshida
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Brain Res Mol Brain Res 133:95-101. 2005
    ..We conclude that PAF enhances NGF gene expression in human astrocytes, and the PAF-induced increase in the expression of NGF under hypoxia may benefit the protection of the nervous tissue by promoting neuronal survival...
  41. ncbi request reprint Edaravone inhibits the expression of vascular endothelial growth factor in human astrocytes exposed to hypoxia
    Akira Ishikawa
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Neurosci Res 59:406-12. 2007
    ..These findings offer a partial explanation for the protective effect of edaravone on the development of brain edema in patients with acute ischemic stroke...
  42. ncbi request reprint Upregulation of alpha-synuclein by lipopolysaccharide and interleukin-1 in human macrophages
    Kunikazu Tanji
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Pathol Int 52:572-7. 2002
    ..These findings suggest that the function of alpha-synuclein is not exclusive to the nervous system and that alpha-synuclein may play a role in inflammatory processes and immune responses...
  43. doi request reprint Edaravone and carnosic acid synergistically enhance the expression of nerve growth factor in human astrocytes under hypoxia/reoxygenation
    Hidemi Yoshida
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Neurosci Res 69:291-8. 2011
    ..We conclude that the use of edaravone and CA in combination may have therapeutic potential in the treatment of brain damage, particularly ischemia/reperfusion injury...
  44. ncbi request reprint Glycogen synthase kinase-3beta phosphorylates synphilin-1 in vitro
    Kunikazu Tanji
    Department of Neuropathology, Hirosaki University School of Medicine, Hirosaki, Japan
    Neuropathology 23:199-202. 2003
    ..Therefore, phosphorylation of synphilin-1 may play an important role in the function of this protein in the brain...
  45. doi request reprint Carnosic acid suppresses the production of amyloid-β 1-42 by inducing the metalloprotease gene TACE/ADAM17 in SH-SY5Y human neuroblastoma cells
    Pengfei Meng
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Neurosci Res 75:94-102. 2013
    ..These results suggest that CA reduces Aβ42 production by activating TACE without promoting BACE1 in human neuroblastoma cells. The use of CA may have a potential in the prevention of Aβ-mediated diseases, particularly AD...
  46. doi request reprint Effects of Brazilian green propolis on double-stranded RNA-mediated induction of interferon-inducible gene and inhibition of recruitment of polymorphonuclear cells
    Ryo Hayakari
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    J Sci Food Agric 93:646-51. 2013
    ..Propolis is a bee product with various biological properties, including an antiviral activity when taken orally. However, its mechanisms at the cellular and molecular level are not well understood...
  47. ncbi request reprint Interferon-alpha2b induces p21cip1/waf1 degradation and cell proliferation in HeLa cells
    Ken Ota
    Department of Gastroenterology and Hematology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Cell Cycle 9:131-9. 2010
    ..These results provide a novel role of Type I IFNs in cell cycle regulation and may define an importance of individualized IFN-based therapy against specific types of cancer...
  48. ncbi request reprint 15-Deoxy-delta(12,14)-prostaglandin J2 inhibits the IL-1beta-induced expression of granulocyte-macrophage colony-stimulating factor in BEAS-2B bronchial epithelial cells
    Mika Kumagai
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Tohoku J Exp Med 202:69-76. 2004
    ..15d-PGJ2 regulates GM-CSF expression in the bronchial epithelium, which may be mediated through a mechanism unrelated to PPAR-gamma...
  49. ncbi request reprint Interferon-gamma upregulates retinoic acid-inducible gene-I in human pericardial mesothelial cells
    Masaharu Hatakeyama
    Department of Surgery, Hirosaki University School of Medicine, Hirosaki, Japan
    Acta Cardiol 62:553-7. 2007
    ..We have addressed the expression of RIG-I in pericardial mesothelial cells...
  50. ncbi request reprint Upregulation of vascular endothelial growth factor by heat-killed Listeria monocytogenes in macrophages
    Fuyuki Sato
    Department of Pathology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Biochem Biophys Res Commun 354:608-12. 2007
    ..monocytogenes (L. monocytogenes). VEGF is thought to be involved in inflammatory reactions induced by L. monocytogenes infection...
  51. doi request reprint Retinoic acid-inducible gene-I is induced by double-stranded RNA and regulates the expression of CC chemokine ligand (CCL) 5 in human mesangial cells
    Tadaatsu Imaizumi
    Department Vascular Biology, Hirosaki University Graduate School of Medicine, Zaifu cho, Hirosaki, Japan
    Nephrol Dial Transplant 25:3534-9. 2010
    ..The purpose of the present study was to investigate the role of RIG-I in glomerular diseases...
  52. doi request reprint Characterization of synergistic induction of CX3CL1/fractalkine by TNF-alpha and IFN-gamma in vascular endothelial cells: an essential role for TNF-alpha in post-transcriptional regulation of CX3CL1
    Tomoh Matsumiya
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    J Immunol 184:4205-14. 2010
    ..CX3CL1 expression is under control of posttranscriptional regulation, which is involved in the synergistic induction of CX3CL1 in response to the combined stimulation with TNF-alpha and IFN-gamma...
  53. doi request reprint Basic-helix-loop-helix (bHLH) transcription factor DEC2 negatively regulates vascular endothelial growth factor expression
    Fuyuki Sato
    Department of Pathology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Genes Cells 13:131-44. 2008
    ..DEC2 had a circadian oscillation in implanted Sarcoma 180 cells. We conclude that DEC2 negatively regulates VEGF expression and plays an important role in the pathological conditions in which VEGF is involved...
  54. pmc Double-stranded RNA induces biphasic STAT1 phosphorylation by both type I interferon (IFN)-dependent and type I IFN-independent pathways
    Junichi Dempoya
    Department of Cardiology, Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    J Virol 86:12760-9. 2012
    ..Collectively, our study provides evidence of a comprehensive regulatory mechanism in which dsRNA induces STAT1 phosphorylation, indicating the importance of STAT1 in maintaining very tight regulation of the innate immune system...
  55. ncbi request reprint Interleukin-1 induces the expression of vascular endothelial growth factor in human pericardial mesothelial cells
    Masaharu Hatakeyama
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Heart Vessels 22:123-7. 2007
    ..We conclude that pericardial mesothelial cells express VEGF, which may serve as an autocrine growth-regulatory mechanism...
  56. ncbi request reprint Proteasome inhibitor MG-132 enhances the expression of interleukin-6 in human umbilical vein endothelial cells: Involvement of MAP/ERK kinase
    Takeo Shibata
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Immunol Cell Biol 80:226-30. 2002
    ..We conclude that a protease inhibitor MG-132 upregulates IL-6 expression in vascular endothelial cells, at least in part, through the activation of MEK 1/2...
  57. ncbi request reprint Heparin inhibits IFN-gamma-induced fractalkine/CX3CL1 expression in human endothelial cells
    Masaharu Hatakeyama
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Inflammation 28:7-13. 2004
    ..Heparin may play a regulatory role in inflammatory and immune responses by modulating the interaction between leukocytes and the vascular endothelium...
  58. ncbi request reprint Photodynamic therapy with mono-L-aspartyl chlorin e6 can cause necrosis of squamous cell carcinoma of tongue: experimental study on an animal model of nude mouse
    Wataru Kobayashi
    Department of Oral and Maxillofacial Surgery, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Oral Oncol 42:46-50. 2006
    ..3 mm. Tumor thickness coincided with the depth of necrosis. NPe6-induced PDT exhibited tumor selectivity and can effectively cause necrosis of tongue cancers. This therapy could be suggested for treatment of other superficial oral cancer...
  59. ncbi request reprint Expression of alpha-synuclein, the precursor of non-amyloid beta component of Alzheimer's disease amyloid, in human cerebral blood vessels
    Wakako Tamo
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Neurosci Lett 326:5-8. 2002
    ..alpha-S is normally expressed in vascular cells and may play some physiological role in the vascular wall...
  60. ncbi request reprint Double-stranded RNA enhances the expression of galectin-9 in vascular endothelial cells
    Akira Ishikawa
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifucho, 036 8562, Japan
    Immunol Cell Biol 82:410-4. 2004
    ..We conclude that poly IC upregulates galectin-9 expression in the vascular endothelium and this may explain part of the mechanism for leucocyte traffic through the vascular wall...
  61. ncbi request reprint Expression of vascular endothelial growth factor in human monocyte/macrophages stimulated with lipopolysaccharide
    H Itaya
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Japan
    Thromb Haemost 85:171-6. 2001
    ..We conclude that macrophages produce VEGF in response to the stimulation with LPS, which may be partly mediated by the p38 MAP kinase pathway...
  62. ncbi request reprint Retinoic acid-inducible gene-I is induced by interferon-gamma and regulates the expression of interferon-gamma stimulated gene 15 in MCF-7 cells
    Xue fan Cui
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562, Japan
    Biochem Cell Biol 82:401-5. 2004
    ..We conclude that IFN-gamma induces the expression of RIG-I, which may play a role in the immunological effects of IFN-gamma...
  63. pmc Foreign RNA induces the degradation of mitochondrial antiviral signaling protein (MAVS): the role of intracellular antiviral factors
    Fei Xing
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    PLoS ONE 7:e45136. 2012
    ..Taken together, these results suggest that the comprehensive regulation of MAVS in response to foreign RNA may be essential to antiviral host defenses...
  64. ncbi request reprint Parkin is expressed in vascular endothelial cells
    Wakako Tamo
    Department of Vascular Biology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Neurosci Lett 419:199-201. 2007
    ..Expression of parkin in HUVEC was not altered with tunicamycin treatment, which exerts unfolded protein stress on cells. We conclude that parkin is expressed in VEC, and that unfolded protein stress may not regulate its expression...
  65. doi request reprint Retinoic acid-inducible gene-I is induced by interferon-gamma and regulates CXCL11 expression in HeLa cells
    Ei Yuzawa
    Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562, Japan
    Life Sci 82:670-5. 2008
    ..Immunohistochemical studies revealed the RIG-I expression in the normal human endometrium, suggesting a possible role of RIG-I in human reproductive organs...
  66. ncbi request reprint Hypoxia enhances the expression of plasminogen activator inhibitor-1 in human lung cancer cells, EBC-1
    Daisuke Kimura
    The First Department of Surgery, Institute of Brain Science, Hirosaki University School of Medicine, Japan
    Tohoku J Exp Med 196:259-67. 2002
    ..We conclude that hypoxia induces PAI-1 expression, in EBC-1 cells, through the stabilization of HIF-1 complex and this may be related to cancer metastasis...
  67. ncbi request reprint Interleukin-1 induces tau phosphorylation and morphological changes in cultured human astrocytes
    Kunikazu Tanji
    Department of Molecular Biology, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Neuroreport 14:413-7. 2003
    ..The early tau phosphorylation induced by IL-1alpha might create a plastic environment for morphological changes in astrocytes...
  68. doi request reprint Characterization of retinoic acid-inducible gene-I (RIG-I) expression corresponding to viral infection and UVB in human keratinocytes
    Kazuyuki Kimura
    Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    J Dermatol Sci 66:64-70. 2012
    ..In human keratinocytes, RIG-I is induced by IFN-γ and tumor necrosis factor-α stimulation, and is abundantly expressed in psoriatic keratinocytes of the spinous and basal layers...
  69. doi request reprint PERIOD1 (PER1) has anti-apoptotic effects, and PER3 has pro-apoptotic effects during cisplatin (CDDP) treatment in human gingival cancer CA9-22 cells
    Fuyuki Sato
    Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine, Hirosaki 036 8562, Japan
    Eur J Cancer 47:1747-58. 2011
    ..These findings suggest that PER1 and PER3 have anti-apoptotic and pro-apoptotic effects in human gingival cancer CA9-22 cells, respectively. The balance of PER1 and PER3 may modulate apoptotic reactions in gingival cancer cells...
  70. doi request reprint Retinoic acid-inducible gene-I is constitutively expressed and involved in IFN-gamma-stimulated CXCL9-11 production in intestinal epithelial cells
    Shogo Kawaguchi
    Department of Gastroenterology and Hematology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562, Japan
    Immunol Lett 123:9-13. 2009
    ..In conclusion, RIG-I might regulate the gut barrier function in homeostatic and inflammatory conditions...
  71. ncbi request reprint Production of growth related oncogene protein-alpha in human umbilical vein endothelial cells stimulated with soluble interleukin-6 receptor-alpha: role of signal transducers, janus kinase 2 and mitogen-activated kinase kinase
    Tomoh Matsumiya
    Department of Dentistry and Oral Surgery, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Life Sci 70:3179-90. 2002
    ..AG490 pretreatment inhibited the MEK phosphorylation but did not affect the STAT3 phosphorylation. We conclude that sIL-6R induces GRO-alpha expression in HUVEC through the activation of JAK2 and MEK...
  72. doi request reprint PERIOD1 is an anti-apoptotic factor in human pancreatic and hepatic cancer cells
    Fuyuki Sato
    Department of Pathology and Bioscience, Hirosaki University Graduate School of Medicine, Hirosaki 036 8562, Japan
    J Biochem 146:833-8. 2009
    ..These results indicate that PER1 acts as an anti-apoptotic factor in pancreatic cancer cells...
  73. ncbi request reprint Soluble interleukin-6 receptor alpha inhibits the cytokine-Induced fractalkine/CX3CL1 expression in human vascular endothelial cells in culture
    T Matsumiya
    Department of Dentistry and Oral Surgery, Hirosaki University School of Medicine, Hirosaki, 036-8562, Japan
    Exp Cell Res 269:35-41. 2001
    ..sIL-6R may play a regulatory role in immune responses by modulating the interaction between leukocytes and the vascular endothelium...
  74. ncbi request reprint Retinoic acid-inducible gene-I is induced in gingival fibroblasts by lipopolysaccharide or poly IC: possible roles in interleukin-1beta, -6 and -8 expression
    K Kubota
    Department of Dentistry and Oral Surgery, Hirosaki University School of Medicine, Hirosaki, Japan
    Oral Microbiol Immunol 21:399-406. 2006
    ..RIG-I may have important roles in the innate immune response in the regulation of IL-1beta, IL-6 and IL-8 expression in gingival fibroblasts in response to LPS and dsRNA...
  75. ncbi request reprint Cytokine modulation of retinoic acid-inducible gene-I (RIG-I) expression in human epidermal keratinocytes
    Hideo Kitamura
    Department of Dermatology, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    J Dermatol Sci 45:127-34. 2007
    ..Retinoic acid-inducible gene-I (RIG-I) is a member of the DExH/D box family proteins and designated as a putative RNA helicase, which plays various roles in gene expression and cellular functions in response to a variety of RNA viruses...
  76. ncbi request reprint Interleukin-1beta induces matrix metalloproteinase-1 expression in cultured human gingival fibroblasts: role of cyclooxygenase-2 and prostaglandin E2
    H Sakaki
    Department of Dentistry and Oral Surgery, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Oral Dis 10:87-93. 2004
    ....
  77. ncbi request reprint Retinoic acid-inducible gene-I is induced by interleukin-1beta in cultured human gingival fibroblasts
    H Sakaki
    Department of Dentistry and Oral Surgery, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Oral Microbiol Immunol 20:47-50. 2005
    ..In contrast, RIG-I overexpression did not alter the level of mRNA for monocyte chemoattractant protein-1. We conclude that IL-1beta stimulates RIG-I expression in human gingival fibroblasts...
  78. ncbi request reprint Interferon-gamma stimulates fractalkine expression in human bronchial epithelial cells and regulates mononuclear cell adherence
    K Fujimoto
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Am J Respir Cell Mol Biol 25:233-8. 2001
    ..We conclude that IFN-gamma stimulates fractalkine expression by bronchial epithelial cells, which may play an important role in inflammatory responses by recruiting mononuclear leukocytes to the bronchial epithelium...
  79. ncbi request reprint Interleukin-1beta stimulates galectin-9 expression in human astrocytes
    H Yoshida
    Departments of Vascular Biology, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan
    Neuroreport 12:3755-8. 2001
    ..Dexamethasone pretreatment almost completely suppressed the production. We conclude that astrocytes produce galectin-9 in response to the stimulation with IL-1beta, and this may contribute to inflammatory reactions in the CNS...
  80. ncbi request reprint Photodynamic therapy upregulates expression of Mac-1 and generation of leukotriene B(4) by human polymorphonuclear leukocytes
    Wataru Kobayashi
    Department of Oral and Maxillofacial Surgery, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Oral Oncol 40:506-10. 2004
    ..These results suggest that PDT can induce PMNs to express extensively Mac-1 and generate a certain amount of LTB(4) that may play an important cytocidal role in the treatment of oral cancer...
  81. doi request reprint Antiviral signaling through retinoic acid-inducible gene-I-like receptors
    Tomoh Matsumiya
    Department of Vascular Biology, Institute of Brain Science, Graduate School of Medicine, Hirosaki University, 5 Zaifu cho, Hirosaki City, Aomori, 036 8562, Japan
    Arch Immunol Ther Exp (Warsz) 59:41-8. 2011
    ..In this review, we comprehensively update RLR-dependent antiviral signaling with special reference to the RLRs/MAVS-mediated responses...
  82. ncbi request reprint Desferrioxamine, an iron chelator, upregulates cyclooxygenase-2 expression and prostaglandin production in a human macrophage cell line
    K Tanji
    Department of Molecular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Japan
    Biochim Biophys Acta 1530:227-35. 2001
    ..These findings suggest that iron metabolism may regulate inflammatory processes by modulating PGs as well as other inflammatory mediators...
  83. ncbi request reprint Synergistic stimulation, by tumor necrosis factor-alpha and interferon-gamma, of fractalkine expression in human astrocytes
    H Yoshida
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifu cho, 036 8562, Hirosaki, Japan
    Neurosci Lett 303:132-6. 2001
    ..We conclude that normal human astrocytes produce fractalkine by co-stimulation with pro-inflammatory cytokines and it may serve as a potential signal for immune and inflammatory responses in the central nervous system...
  84. ncbi request reprint An oxidized derivative of cholesterol increases the release of soluble vascular cell adhesion molecule-1 from human umbilical vein endothelial cells in culture
    N Tamasawa
    Third Department of Internal Medicine, Hirosaki University School of Medicine, Japan
    Biochim Biophys Acta 1531:178-87. 2001
    ..We conclude that 7-ketocholesterol releases VCAM-1 from the endothelium probably by a proteolytic process...
  85. ncbi request reprint Double-stranded RNA induces the synthesis of retinoic acid-inducible gene-I in vascular endothelial cells
    T Imaizumi
    Department of Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Endothelium 12:133-7. 2005
    ..Induction of RIG-I by poly IC may be involved in the antiviral responses in endothelial cells...
  86. ncbi request reprint Expression of alpha-synuclein in a human glioma cell line and its up-regulation by interleukin-1beta
    K Tanji
    Departments of Molecular Biology and 1Vascular Biology, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan
    Neuroreport 12:1909-12. 2001
    ..These findings suggest that human astrocytes can produce alpha-synuclein in culture and that certain inflammatory cytokines and cell stress increase alpha-synuclein expression...
  87. ncbi request reprint Cisplatin inhibits the expression of X-chromosome-linked inhibitor of apoptosis protein in an oral carcinoma cell line
    T Matsumiya
    Department of Dentistry and Oral Surgery, School of Medicine, Hirosaki University, Hirosaki, 036-8562, Japan
    Oral Oncol 37:296-300. 2001
    ..Overexpression of XIAP, by a transfection experiment, inhibited the cisplatin-induced apoptosis. We conclude that cisplatin induces apoptosis mediated not only by the activation of MAPK pathway but by the inhibition of XIAP...
  88. doi request reprint Metformin restores impaired HDL-mediated cholesterol efflux due to glycation
    Kota Matsuki
    Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036 8562, Japan
    Atherosclerosis 206:434-8. 2009
    ..Metformin serves as a possible candidate to restore impaired cholesterol efflux and reverse cholesterol transport...
  89. ncbi request reprint Differential regulation of CREB and ERK phosphorylation through corticotropin-releasing factor receptors type 1 and 2 in AtT-20 and A7r5 cells
    Kazunori Kageyama
    Department of Endocrinology, Metabolism and Infectious Diseases, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    Mol Cell Endocrinol 263:90-102. 2007
    ..These findings suggest differential regulation of CREB and ERK 1/2 phosphorylation through CRF receptors...
  90. ncbi request reprint Expression of beta-synuclein in normal human astrocytes
    K Tanji
    Department of Molecular Biology, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Neuroreport 12:2845-8. 2001
    ..The novel expression of beta-synuclein in astrocytes may provide an important insight about the role of this protein...
  91. doi request reprint Retinoic acid-inducible gene-I (RIG-I) is induced by IFN-{gamma} in human mesangial cells in culture: possible involvement of RIG-I in the inflammation in lupus nephritis
    T Imaizumi
    Department of Vascular Biology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Lupus 19:830-6. 2010
    ..These findings suggest that retinoic acid-inducible gene-I produced by mesangial cells may be involved in the pathogenesis of lupus nephritis...
  92. pmc Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD
    Minying Zhang
    Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 283:18621-6. 2008
    ..These findings establish CYLD as a key negative regulator of IKKepsilon/TBK1 and suggest a role for CYLD in the control of RIG-I ubiquitination...
  93. ncbi request reprint Selective eosinophil adhesion to fibroblast via IFN-gamma-induced galectin-9
    Hirofumi Asakura
    Department of Radiology, Kagawa Medical University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
    J Immunol 169:5912-8. 2002
    ....
  94. pmc Regulation of CXCL-8 (interleukin-8) induction by double-stranded RNA signaling pathways during hepatitis C virus infection
    Jessica Wagoner
    Department of Laboratory Medicine, University of Washington, Virology 359690, 325 9th Avenue, Seattle, WA 98104 2499, USA
    J Virol 81:309-18. 2007
    ....
  95. ncbi request reprint Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity
    Mitsutoshi Yoneyama
    Antiviral Innate Immunity Project, Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, Honkomagome, Tokyo, Japan
    J Immunol 175:2851-8. 2005
    ..These results highlight ingenious mechanisms for initiating antiviral innate immune responses and the action of virus-encoded inhibitors...
  96. pmc Negative feedback regulation of RIG-I-mediated antiviral signaling by interferon-induced ISG15 conjugation
    Min Jung Kim
    Department of Life Sciences, Pohang University of Science and Technology POSTECH, Pohang 790 784, Republic of Korea
    J Virol 82:1474-83. 2008
    ..Based on these results, we propose a novel negative feedback loop which adjusts the strength of the RIG-I-mediated antiviral response and IFN production through the regulation of RIG-I protein by IFN-induced ISG15 conjugation...
  97. ncbi request reprint The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
    Mitsutoshi Yoneyama
    Department of Tumor Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, 3 18 22 Honkomagome, Bunkyo ku, Tokyo 113 8613, Japan
    Nat Immunol 5:730-7. 2004
    ..Subsequent gene activation by these factors induced antiviral functions, including type I interferon production. Thus, RIG-I is key in the detection and subsequent eradication of the replicating viral genomes...
  98. pmc EB virus-encoded RNAs are recognized by RIG-I and activate signaling to induce type I IFN
    Mrinal Samanta
    Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    EMBO J 25:4207-14. 2006
    ..It was also shown that EBERs co-precipitated with RIG-I. These results indicate that EBERs are recognized by RIG-I and activate signaling to induce type I IFN in EBV-infected cells...
  99. ncbi request reprint Quantification of galectin-7 and its localization in adult mouse tissues
    Miki Sato
    Department of Plastic and Reconstructive Surgery, Faculty of Medicine, Kagawa Medical University, Kagawa 761 0793, Japan
    J Biochem 131:255-60. 2002
    ..Thus, galectin-7 protein might be produced primarily in stratified epithelia, but also in some wet epithelia, and plays a unique role in cell-mucus contact, or the growth of ovarian follicles...
  100. ncbi request reprint Retinoic acid inducible gene-I and mda-5 are involved in influenza A virus-induced expression of antiviral cytokines
    Jukka Sirén
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    Microbes Infect 8:2013-20. 2006
    ..In conclusion, our results show that in epithelial cells influenza A virus-induced antiviral cytokine gene expression is triggered by RIG-I and mda-5, whose expression is positively regulated by IFN-alpha...
  101. ncbi request reprint Expression of retinoic acid-inducible gene-I in lupus nephritis
    Koichi Suzuki
    Nephrol Dial Transplant 22:2407-9. 2007