Tadaatsu Imaizumi

Summary

Affiliation: Hirosaki University School of Medicine
Country: Japan

Publications

  1. Imaizumi T, Sakashita N, Mushiga Y, Yoshida H, Hayakari R, Xing F, et al. Desferrioxamine, an iron chelator, inhibits CXCL10 expression induced by polyinosinic-polycytidylic acid in U373MG human astrocytoma cells. Neurosci Res. 2015;94:10-6 pubmed publisher
    ..Iron may contribute to innate immune and inflammatory reactions elicited by the TLR3 signaling in astrocytes, and may play an important role in neuroinflammatory diseases. ..
  2. Tamura R, Yokoyama Y, Yoshida H, Imaizumi T, Mizunuma H. 4-Methylumbelliferone inhibits ovarian cancer growth by suppressing thymidine phosphorylase expression. J Ovarian Res. 2014;7:94 pubmed publisher
    ..These results suggest that 4-MU exerts its antitumor effect on ovarian cancer through suppressing TP expression. ..
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    Imaizumi T, Kumagai M, Sasaki N, Kurotaki H, Mori F, Seki M, et al. Interferon-gamma stimulates the expression of galectin-9 in cultured human endothelial cells. J Leukoc Biol. 2002;72:486-91 pubmed
    ..IFN-gamma-induced production of galectin-9 by endothelial cells may play an important role in immune responses by regulating interactions between the vascular wall and eosinophils. ..
  4. Imaizumi T, Sato F, Tanaka H, Matsumiya T, Yoshida H, Yashiro Aizawa T, et al. Basic-helix-loop-helix transcription factor DEC2 constitutes negative feedback loop in IFN-?-mediated inflammatory responses in human mesangial cells. Immunol Lett. 2011;136:37-43 pubmed publisher
    ..DEC2 expression may constitute a negative feedback system for the IFN-?/RIG-I/CCL5 pathway in the glomerulus, which may play a role in controlling protracted inflammatory reactions in the kidney. ..
  5. Imaizumi T, Murakami K, Ohta K, Seki H, Matsumiya T, Meng P, et al. MDA5 and ISG56 mediate CXCL10 expression induced by toll-like receptor 4 activation in U373MG human astrocytoma cells. Neurosci Res. 2013;76:195-206 pubmed publisher
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    Imaizumi T, Aratani S, Nakajima T, Carlson M, Matsumiya T, Tanji K, et al. Retinoic acid-inducible gene-I is induced in endothelial cells by LPS and regulates expression of COX-2. Biochem Biophys Res Commun. 2002;292:274-9 pubmed
    ..RIG-I is an inducible gene in stimulated endothelial cells that may have important roles in vascular pathology by virtue of its ability to regulate expression of the COX-2 gene product. ..
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    Imaizumi T, Yagihashi N, Hatakeyama M, Yamashita K, Ishikawa A, Taima K, et al. Expression of retinoic acid-inducible gene-I in vascular smooth muscle cells stimulated with interferon-gamma. Life Sci. 2004;75:1171-80 pubmed
    ..Immunohistochemical analysis revealed the expression of RIG-I in SMC in vivo. We conclude that RIG-I may play some pathophysiological role in immune and inflammatory reactions in SMC. ..
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    Imaizumi T, Yagihashi N, Hatakeyama M, Yamashita K, Ishikawa A, Taima K, et al. Upregulation of retinoic acid-inducible gene-I in T24 urinary bladder carcinoma cells stimulated with interferon-gamma. Tohoku J Exp Med. 2004;203:313-8 pubmed
    ..We conclude that RIG-I may play some role in inflammatory reactions in the urinary tract epithelium. ..
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    Imaizumi T, Hatakeyama M, Yamashita K, Yoshida H, Ishikawa A, Taima K, et al. Interferon-gamma induces retinoic acid-inducible gene-I in endothelial cells. Endothelium. 2004;11:169-73 pubmed
    ..Although the physiological function of RIG-I is still unknown, induction of RIG-I by IFN-gamma may play an important role in inflammatory or immunological reactions in endothelial cells. ..

More Information

Publications14

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    Imaizumi T, Yoshida H, Nishi N, Sashinami H, Nakamura T, Hirashima M, et al. Double-stranded RNA induces galectin-9 in vascular endothelial cells: involvement of TLR3, PI3K, and IRF3 pathway. Glycobiology. 2007;17:12C-5C pubmed
    ..RNAi against interferon regulatory factor 3 (IRF3) also inhibited poly IC-induced galectin-9 expression. We conclude that TLR3, PI3K, and IRF3 are involved in the poly IC-induced galectin-9 expression in HUVECs. ..
  2. Imaizumi T, Matsumiya T, Yoshida H, Naraoka T, Uesato R, Ishibashi Y, et al. Tumor-necrosis factor-alpha induces retinoic acid-inducible gene-I in rheumatoid fibroblast-like synoviocytes. Immunol Lett. 2009;122:89-93 pubmed publisher
    ..These findings suggest that the TNF-alpha/IFN-beta/RIG-I/CCL5 pathway may be involved in the pathogenesis of synovial inflammation in RA. ..
  3. Imaizumi T, Tanaka H, Tajima A, Yokono Y, Matsumiya T, Yoshida H, et al. IFN-? and TNF-? synergistically induce microRNA-155 which regulates TAB2/IP-10 expression in human mesangial cells. Am J Nephrol. 2010;32:462-8 pubmed publisher
    ..miR-155 negatively regulates TAB2, as a negative feedback system, to lower IP-10 expression. miR-155 may play a role in the regulation of inflammatory and immune reactions in the kidney. ..
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    Imaizumi T, Aizawa Yashiro T, Tsuruga K, Tanaka H, Matsumiya T, Yoshida H, et al. Melanoma differentiation-associated gene 5 regulates the expression of a chemokine CXCL10 in human mesangial cells: implications for chronic inflammatory renal diseases. Tohoku J Exp Med. 2012;228:17-26 pubmed
    ..MDA5 may be involved not only in physiological antiviral reactions but also in chronic inflammation in glomerular mesangial cells. ..
  5. Imaizumi T, Aizawa Yashiro T, Matsumiya T, Yoshida H, Watanabe S, Tsuruga K, et al. Interaction between interferon-stimulated gene 56 and melanoma differentiation-associated gene 5 in Toll-like receptor 3 signaling in normal human mesangial cells. Am J Nephrol. 2013;37:118-25 pubmed publisher
    ..ISG56 may play a role in immune and inflammatory reactions induced by TLR3 signaling in human mesangial cells. ..