Masahiko Endo

Summary

Affiliation: Hirosaki University School of Medicine
Country: Japan

Publications

  1. pmc Synthesis of neoproteoglycans using the transglycosylation reaction as a reverse reaction of endo-glycosidases
    Masahiko Endo
    Department of Glycobiochemistry, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Proc Jpn Acad Ser B Phys Biol Sci 88:327-44. 2012
  2. doi Mechanism for the hydrolysis of hyaluronan oligosaccharides by bovine testicular hyaluronidase
    Ikuko Kakizaki
    Department of Glycotechnology, Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine, Japan
    FEBS J 277:1776-86. 2010
  3. doi Epiphycan from salmon nasal cartilage is a novel type of large leucine-rich proteoglycan
    Yota Tatara
    Department of Glycotechnology, Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Glycobiology 23:993-1003. 2013
  4. ncbi Reconstruction of glycosaminoglycan chains in decorin
    Mito Iwafune
    Department of Biochemistry, Hirosaki University School of Medicine, 5 Zaifu cho, 036 8562, Hirosaki, Japan
    Biochem Biophys Res Commun 297:1167-70. 2002
  5. doi Hyaluronan-chondroitin hybrid oligosaccharides as new life science research tools
    Ikuko Kakizaki
    Department of Glycotechnology, Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Biochem Biophys Res Commun 423:344-9. 2012
  6. doi Stimulation of small proteoglycan synthesis by the hyaluronan synthesis inhibitor 4-methylumbelliferone in human skin fibroblasts
    Masaru Funahashi
    Department of Glycotechnology, Center for Advanced Medical Research, and Departments of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, Japan
    Connect Tissue Res 50:194-202. 2009
  7. doi Novel products in hyaluronan digested by bovine testicular hyaluronidase
    Fengchao Chen
    Department of Glycotechnology, Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Glycoconj J 26:559-66. 2009
  8. ncbi Interaction between proteoglycans and alpha-elastin in construction of extracellular matrix of human yellow ligament
    Taito Itabashi
    Departments of Biochemistry and Orthopaedic Surgery, Hirosaki University School of Medicine, Hirosaki, Japan
    Connect Tissue Res 46:67-73. 2005
  9. doi Identification of proteoglycan from salmon nasal cartilage
    Ikuko Kakizaki
    Department of Glycotechnology, Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Arch Biochem Biophys 506:58-65. 2011
  10. doi Chondroitin sulfate cluster of epiphycan from salmon nasal cartilage defines binding specificity to collagens
    Yota Tatara
    Department of Glycotechnology, Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine, Hirosaki 036 8562, Japan Department of Glycobiomedicine, Hirosaki University Graduate School of Medicine, Hirosaki 036 8562, Japan
    Glycobiology 25:557-69. 2015

Collaborators

Detail Information

Publications14

  1. pmc Synthesis of neoproteoglycans using the transglycosylation reaction as a reverse reaction of endo-glycosidases
    Masahiko Endo
    Department of Glycobiochemistry, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Proc Jpn Acad Ser B Phys Biol Sci 88:327-44. 2012
    ..We believe this approach will open a new field for the synthesis of homogeneous proteoglycans or their corresponding analogues...
  2. doi Mechanism for the hydrolysis of hyaluronan oligosaccharides by bovine testicular hyaluronidase
    Ikuko Kakizaki
    Department of Glycotechnology, Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine, Japan
    FEBS J 277:1776-86. 2010
    ....
  3. doi Epiphycan from salmon nasal cartilage is a novel type of large leucine-rich proteoglycan
    Yota Tatara
    Department of Glycotechnology, Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Glycobiology 23:993-1003. 2013
    ..EPY is heavily substituted by chondroitin sulfate, giving an overall molecular weight of just under 2 × 10(6). EPY from salmon nasal cartilage is a novel type of large leucine-rich proteoglycan. ..
  4. ncbi Reconstruction of glycosaminoglycan chains in decorin
    Mito Iwafune
    Department of Biochemistry, Hirosaki University School of Medicine, 5 Zaifu cho, 036 8562, Hirosaki, Japan
    Biochem Biophys Res Commun 297:1167-70. 2002
    ..Similarly, it was possible to reconstruct the glycosaminoglycan chain in decorin to chondroitin, chondroitin 4-sulfate or chondroitin 6-sulfate. Therefore, we succeeded in synthesizing an artificial family of decorins...
  5. doi Hyaluronan-chondroitin hybrid oligosaccharides as new life science research tools
    Ikuko Kakizaki
    Department of Glycotechnology, Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Biochem Biophys Res Commun 423:344-9. 2012
    ..We hope that these hybrid oligosaccharides will help to elucidate the involvement of hyaluronan, chondroitin, and chondroitin sulfates in the mechanisms of cell functions and diseases, based on the structures of these glycosaminoglycans...
  6. doi Stimulation of small proteoglycan synthesis by the hyaluronan synthesis inhibitor 4-methylumbelliferone in human skin fibroblasts
    Masaru Funahashi
    Department of Glycotechnology, Center for Advanced Medical Research, and Departments of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, Japan
    Connect Tissue Res 50:194-202. 2009
    ..Furthermore, the two decorins had galactosaminoglycan chains of different sizes. These results suggest that MU inhibits the synthesis of hyaluronan and accelerates production of the larger decorin in the extracellular matrix...
  7. doi Novel products in hyaluronan digested by bovine testicular hyaluronidase
    Fengchao Chen
    Department of Glycotechnology, Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Glycoconj J 26:559-66. 2009
    ....
  8. ncbi Interaction between proteoglycans and alpha-elastin in construction of extracellular matrix of human yellow ligament
    Taito Itabashi
    Departments of Biochemistry and Orthopaedic Surgery, Hirosaki University School of Medicine, Hirosaki, Japan
    Connect Tissue Res 46:67-73. 2005
    ..In the ossified ligaments, neodesmosine, one of the cross-linking amino acids, was significantly less than in the normal ligaments (p < .05)...
  9. doi Identification of proteoglycan from salmon nasal cartilage
    Ikuko Kakizaki
    Department of Glycotechnology, Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Arch Biochem Biophys 506:58-65. 2011
    ..Based on cDNA analysis and amino acid analysis after β-elimination, the ratio of serine attached to sugar chains was calculated to be approximately 37.7% of total serine, that is, 46 of 123 serine residues...
  10. doi Chondroitin sulfate cluster of epiphycan from salmon nasal cartilage defines binding specificity to collagens
    Yota Tatara
    Department of Glycotechnology, Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine, Hirosaki 036 8562, Japan Department of Glycobiomedicine, Hirosaki University Graduate School of Medicine, Hirosaki 036 8562, Japan
    Glycobiology 25:557-69. 2015
    ..The clustered CS was also involved in an inter-saccharide interaction, and formed self-associated EPY. CS of EPY promoted fibril formation of type I collagen. ..
  11. doi One set system for the synthesis and purification of glycosaminoglycan oligosaccharides reconstructed using a hyaluronidase-immobilized column
    Shinichiro Suto
    Department of Glycobiochemistry, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562, Japan Department of Glycotechnology, Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562, Japan
    Biopolymers 101:189-96. 2014
    ..Newly synthesized oligosaccharides were obtained by one complete cycle of the transglycosylation reaction and separation. © 2013 Wiley Periodicals, Inc. Biopolymers 101: 189-196, 2014. ..
  12. doi Inhibitory effect of chondroitin sulfate oligosaccharides on bovine testicular hyaluronidase
    Ikuko Kakizaki
    Department of Glycotechnology, Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan Department of Glycobiochemistry, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan Electronic address
    Carbohydr Polym 121:362-71. 2015
    ..A kinetic analysis of the hydrolysis reaction using hyaluronan octasaccharide revealed that the inhibition mode by chondroitin sulfate oligosaccharides was competitive. ..
  13. ncbi Inhibition of hyaluronan synthesis in Streptococcus equi FM100 by 4-methylumbelliferone
    Ikuko Kakizaki
    Departments of Biochemistry and Bacteriology, Hirosaki University School of Medicine, Hirosaki, Japan
    Eur J Biochem 269:5066-75. 2002
    ..These results suggest that MU treatment may cause a decrease in hyaluronan synthase activity by altering the lipid environment of membranes, especially the distribution of different cardiolipin species, surrounding hyaluronan synthase...
  14. ncbi Cleavage of the xylosyl serine linkage between a core peptide and a glycosaminoglycan chain by cellulases
    Keiichi Takagaki
    Department of Biochemistry, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Japan
    J Biol Chem 277:18397-403. 2002
    ....