Hirosaki University School of Medicine

Summary

Organization: Hirosaki University School of Medicine
Country: Japan

Top Publications

  1. doi Profiling of somatostatin receptor subtype expression by quantitative PCR and correlation with clinicopathological features in pancreatic endocrine tumors
    Yoshihito Nakayama
    Departments of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Pancreas 39:1147-54. 2010
  2. doi Granulomatous prostatitis due to Cryptococcus neoformans: diagnostic usefulness of special stains and molecular analysis of 18S rDNA
    R Wada
    Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Prostate Cancer Prostatic Dis 11:203-6. 2008
  3. pmc Anaplastic carcinoma associated with a mucinous cystic neoplasm of the pancreas during pregnancy: report of a case and a review of the literature
    Kenichi Hakamada
    Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    World J Gastroenterol 14:132-5. 2008
  4. ncbi Management of an aorto-caval fistula from a ruptured aortic false aneurysm using a covered stent graft
    Ikuo Fukuda
    Department of Cardiovascular Surgery, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori, 036 8562, Japan
    Interact Cardiovasc Thorac Surg 6:682-4. 2007
  5. ncbi Long-term intermittent pulse therapy with mizoribine attenuates histologic progression in young patients with severe lupus nephritis: report of two patients
    Hiroshi Tanaka
    Department of Pediatrics, Hirosaki University School of Medicine, Hirosaki, Japan
    Nephrology (Carlton) 12:376-9. 2007
  6. ncbi Upregulation of vascular endothelial growth factor by heat-killed Listeria monocytogenes in macrophages
    Fuyuki Sato
    Department of Pathology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Biochem Biophys Res Commun 354:608-12. 2007
  7. ncbi A pregnant woman with genetic variants of butyrylcholinesterase and inflammatory bowel disease
    M Futagami
    Department of Obstetrics and Gynaecology, Hirosaki University School of Medicine, Japan
    J Obstet Gynaecol 26:562-3. 2006
  8. ncbi Effect of clot removal and the different incidence of vasospasm between clipping and GDC
    Hiroki Ohkuma
    Department of Neurosurgery, Hirosaki University School of Medicine, Hirosaki, Japan
    Neurol Res 28:424-30. 2006
  9. ncbi Hypoglycemic encephalopathy with extensive lesions in the cerebral white matter
    Fumiaki Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Neuropathology 26:147-52. 2006
  10. ncbi Fatal Baylisascaris larva migrans in a colony of Japanese macaques kept by a safari-style zoo in Japan
    Hiroshi Sato
    Department of Parasitology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    J Parasitol 91:716-9. 2005

Detail Information

Publications62

  1. doi Profiling of somatostatin receptor subtype expression by quantitative PCR and correlation with clinicopathological features in pancreatic endocrine tumors
    Yoshihito Nakayama
    Departments of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Pancreas 39:1147-54. 2010
    ..In this paper, we explore the correlation between the SSTR subtype messenger RNA (mRNA) expression and clinicopathological features of PET...
  2. doi Granulomatous prostatitis due to Cryptococcus neoformans: diagnostic usefulness of special stains and molecular analysis of 18S rDNA
    R Wada
    Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Prostate Cancer Prostatic Dis 11:203-6. 2008
    ..Careful histological and molecular studies are beneficial to reach the correct diagnosis and to prevent an unfavorable outcome of disseminated cryptococcosis...
  3. pmc Anaplastic carcinoma associated with a mucinous cystic neoplasm of the pancreas during pregnancy: report of a case and a review of the literature
    Kenichi Hakamada
    Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    World J Gastroenterol 14:132-5. 2008
    ..Although the origin of anaplastic carcinoma has not been determined yet, it should be remembered that anaplastic carcinoma can occur in association with mucinous cystic neoplasm of more benign histology...
  4. ncbi Management of an aorto-caval fistula from a ruptured aortic false aneurysm using a covered stent graft
    Ikuo Fukuda
    Department of Cardiovascular Surgery, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori, 036 8562, Japan
    Interact Cardiovasc Thorac Surg 6:682-4. 2007
    ..Stent-grafting for abdominal aorta was performed. Intra- and postoperative examination revealed no leakage from the aorta to the vena cava. Endoluminal treatment for aorto-caval fistula is efficacious as less invasive treatment...
  5. ncbi Long-term intermittent pulse therapy with mizoribine attenuates histologic progression in young patients with severe lupus nephritis: report of two patients
    Hiroshi Tanaka
    Department of Pediatrics, Hirosaki University School of Medicine, Hirosaki, Japan
    Nephrology (Carlton) 12:376-9. 2007
    ..These clinical observations may lend further support, from the histologic standpoint, to the efficacy of long-term MZR intermittent pulse therapy for selected patients with active lupus nephritis...
  6. ncbi Upregulation of vascular endothelial growth factor by heat-killed Listeria monocytogenes in macrophages
    Fuyuki Sato
    Department of Pathology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Biochem Biophys Res Commun 354:608-12. 2007
    ..monocytogenes (L. monocytogenes). VEGF is thought to be involved in inflammatory reactions induced by L. monocytogenes infection...
  7. ncbi A pregnant woman with genetic variants of butyrylcholinesterase and inflammatory bowel disease
    M Futagami
    Department of Obstetrics and Gynaecology, Hirosaki University School of Medicine, Japan
    J Obstet Gynaecol 26:562-3. 2006
  8. ncbi Effect of clot removal and the different incidence of vasospasm between clipping and GDC
    Hiroki Ohkuma
    Department of Neurosurgery, Hirosaki University School of Medicine, Hirosaki, Japan
    Neurol Res 28:424-30. 2006
    ..From the results of studies reviewed, the incidence of cerebral vasospasm seems less in GDC cases than in clipping cases. It should be clarified why clipping could not be dominant in the prevention of cerebral vasospasm compared to GDC...
  9. ncbi Hypoglycemic encephalopathy with extensive lesions in the cerebral white matter
    Fumiaki Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Neuropathology 26:147-52. 2006
    ..Since the cerebral blood flow is reported to be decreased during severe hypoglycemia, the present findings suggest that white matter lesions and boundary-zone infarctions may develop primarily in uncomplicated hypoglycemia...
  10. ncbi Fatal Baylisascaris larva migrans in a colony of Japanese macaques kept by a safari-style zoo in Japan
    Hiroshi Sato
    Department of Parasitology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    J Parasitol 91:716-9. 2005
    ..This sporadic outbreak is the second record of Baylisascaris larva migrans in animals in Japan...
  11. ncbi Azulene-substituted aromatic amines. synthesis and amphoteric redox behavior of N,N-Di(6-azulenyl)-p-toluidine and N,N,N',N'-tetra(6-azulenyl)-p-phenylenediamine and their derivatives
    Shunji Ito
    Department of Materials Science and Technology, Faculty of Science and Technology, Hirosaki University, Hirosaki 036 8561, Japan
    J Org Chem 70:2285-93. 2005
    ....
  12. ncbi A tube-fed liquid formula diet containing dietary fiber increased stool weight in bed-ridden elderly patients
    Shigeyuki Nakaji
    Department of Hygiene, Hirosaki University, Aomori, Japan
    Nutrition 20:955-60. 2004
    ..The number of bedridden elderly patients who need a liquid diet has been increasing. We evaluated the usefulness of a tube-fed liquid diet containing cellulose and oligosaccharide for elderly bedridden patients...
  13. ncbi Analysis of clinical variables of donors and recipients with respect to short-term graft outcome in human liver transplantation
    E Totsuka
    Second Department of Surgery, Hirosaki University School of Medicine, Hirosaki, Japan
    Transplant Proc 36:2215-8. 2004
    ..This study was performed to analyze clinical characteristics of recipients and donors, which affect 30-day graft loss after OLT...
  14. ncbi Effects of static magnetic fields at the cellular level
    Junji Miyakoshi
    Department of Radiological Technology, School of Health Sciences, Faculty of Medicine, Hirosaki University, 66 1 Hon cho, Hirosaki 036 8564, Japan
    Prog Biophys Mol Biol 87:213-23. 2005
    ..In addition, many studies have found a strong magnetic field that can induce orientation phenomena in cell culture...
  15. doi Chemosensitivity determinants of irinotecan hydrochloride in hepatocellular carcinoma cell lines
    Takenori Takahata
    First Department of Internal Medicine, and Department of Clinical Pharmacology, Hirosaki University School of Medicine, Aomori, Japan
    Basic Clin Pharmacol Toxicol 102:399-407. 2008
    ..Those results suggest that BCRP is one of the chemosensitivity determinants of CPT-11 in HCC cells and its inhibition might be critical for cells expressing abundant BCRP...
  16. pmc Des-gamma-carboxy prothrombin as an important prognostic indicator in patients with small hepatocellular carcinoma
    Kenichi Hakamada
    Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    World J Gastroenterol 14:1370-7. 2008
    ..To clarify the effect of a high des-gamma-carboxy prothrombin (DCP) level on the invasiveness and prognosis of small hepatocellular carcinoma...
  17. doi Stability evaluation of single-bundle and double-bundle reconstruction during navigated ACL reconstruction
    Yasuyuki Ishibashi
    Department of Orthopaedic Surgery, Hirosaki University School of Medicine, Hirosaki, Aomori, Japan
    Sports Med Arthrosc 16:77-83. 2008
    ..Although traditional single-bundle reconstruction, reproducing the anteromedial bundle, is a reasonable procedure, double-bundle reconstruction has the potential to improve knee stability after ACL reconstruction...
  18. doi Facile preparation of gold nanoparticles through autoreduction of gold ions in the presence of fluoroalkyl end-capped cooligomeric aggregates: LCST-triggered sol-gel switching behavior of novel thermoresponsive fluoroalkyl end-capped cooligomeric nanocomp
    Hideo Sawada
    Department of Frontier Materials Chemistry, Graduate School of Science and Technology, Hirosaki University, Bunkyo cho, Hirosaki 036 8561, Japan
    J Colloid Interface Sci 351:166-70. 2010
    ....
  19. ncbi [An adult with chronic active Epstein-Barr virus infection associated with repeated liver dysfunction]
    Tetsu Endo
    Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine
    Nihon Shokakibyo Gakkai Zasshi 107:1312-8. 2010
    ..Therefore, CAEBV associated with liver dysfunction should be considered during the differential diagnosis of patients showing persistent liver dysfunction...
  20. ncbi Clinicopathological study on hepatitis C virus-associated glomerulonephritis without hepatitis C virus in the blood
    Hideaki Yamabe
    Department of Nephrology, Hirosaki University Graduate School of Medicine, Japan
    Intern Med 49:1321-3. 2010
    ..Patients with hepatitis C virus (HCV)-associated glomerulonephritis in whom HCV RNA was not detected in the blood have been reported. We attempted to uncover the differences between HCV RNA-negative and HCV RNA-positive cases...
  21. doi Involvement of the peripheral nervous system in synucleinopathies, tauopathies and other neurodegenerative proteinopathies of the brain
    Koichi Wakabayashi
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Acta Neuropathol 120:1-12. 2010
    ..Further elucidation and characterization of PNS lesions will have implications for intravital biopsy diagnosis in neurodegenerative proteinopathy, particularly in Parkinson's disease...
  22. doi Relationship between Bunina bodies and TDP-43 inclusions in spinal anterior horn in amyotrophic lateral sclerosis
    F Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, Japan
    Neuropathol Appl Neurobiol 36:345-52. 2010
    ..To elucidate the relationship between BBs and TDP-43 inclusions, we examined the spinal cord from 18 patients with ALS...
  23. doi Tunnel position and relationship to postoperative knee laxity after double-bundle anterior cruciate ligament reconstruction with a transtibial technique
    Eiichi Tsuda
    Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, Hirosaki 036 8562, Japan
    Am J Sports Med 38:698-706. 2010
    ..The tunnel malposition away from the anatomic attachment may result in increased postoperative knee laxity in double-bundle reconstruction...
  24. doi The role of the polyol pathway in acute kidney injury caused by hindlimb ischaemia in mice
    Soroku Yagihashi
    Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    J Pathol 220:530-41. 2010
    ..Thus, these findings suggest that the polyol pathway is implicated in AKI caused by ischaemic limb injury and that AR may be a potential therapeutic target for this condition...
  25. pmc Sagittal realignment osteotomy for increased posterior tibial slope after opening-wedge high tibial osteotomy: a case report
    Yuka Kimura
    Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Sports Med Arthrosc Rehabil Ther Technol 1:26. 2009
    ..We reviewed this unique technique for correction of sagittal malalignment using a closing-wedge osteotomy for revision after opening-wedge osteotomy...
  26. ncbi [Mutational analysis of a thiazide-sensitive Na-Cl cotransporter (SLC12A3) gene in a Japanese population--the Iwaki Health Promotion Project]
    Minoru Yasujima
    Department of Laboratory Medicine, Hirosaki University Graduate School of Medicine, Hirosaki 036 8562, Japan
    Rinsho Byori 57:391-6. 2009
    ..8% in a Japanese population. In addition, these findings suggest that the allele frequency of GS mutations may be higher than expected, although GS is considered to be a rare disorder...
  27. doi Efficacy of a single 24-hour pre-anesthetic dose of proton pump inhibitors
    Kazuyoshi Hirota
    Department of Anesthesiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    J Gastroenterol Hepatol 24:1244-7. 2009
    ..In the present study, we have compared the effects of roxatidine, rabeprazole and lansoprazole given singly at night as an alternative to the standard double roxatidine medication...
  28. doi Irrigation with thrombin solution reduces recurrence of chronic subdural hematoma in high-risk patients: preliminary report
    Norihito Shimamura
    Department of Neurosurgery, Hirosaki University School of Medicine, Hirosaki Aomori, Japan
    J Neurotrauma 26:1929-33. 2009
    ..No complication occurred in relation to thrombin irrigation. Irrigation of CSH with thrombin solution is an effective treatment option for high-risk cases of CSH without complication...
  29. doi Coupling factor 6 enhances Src-mediated responsiveness to angiotensin II in resistance arterioles and cells
    Tomohiro Osanai
    Department of Cardiology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Cardiovasc Res 81:780-7. 2009
    ..Here we investigated the direct effect of exogenous CF6 on Ca2+ signalling in cultured VSMCs and the in vivo role of endogenous CF6 in the genesis of hypertension using CF6 transgenic (TG) mice...
  30. ncbi A bioartificial liver that combines plasma dialysis and whole liver perfusion
    Minoru Umehara
    Department of Surgery, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    Hepatogastroenterology 55:1216-21. 2008
    ..In this system, the patient's plasma was dialyzed with normal plasma recycled through the pig liver...
  31. ncbi Correlation of N-cadherin expression in high grade gliomas with tissue invasion
    Kenichiro Asano
    Department of Neurosurgery, The University of Tennessee Health Science Center, Memphis, TN, USA
    J Neurooncol 70:3-15. 2004
    ..In summary, these data collectively demonstrate that N-cadherin levels are important in the malignant behavior of gliomas, and may serve as a prognostic indicator for patients with high-grade gliomas...
  32. ncbi Nonsurgical correction of congenital auricular deformities in children older than early neonates
    Takatoshi Yotsuyanagi
    Department of Plastic and Reconstructive Surgery, Hirosaki University School of Medicine, Japan
    Plast Reconstr Surg 114:190-1. 2004
  33. ncbi Unventilated airway is time-dependently constricted in paralyzed dogs
    K Hirota
    Department of Anesthesiology, University of Hirosaki School of Medicine, Japan
    Anesthesiology 95:1480-4. 2001
    ..In this study, the authors determined the mechanism of apnea-induced bronchoconstriction...
  34. pmc Orexin A and B evoke noradrenaline release from rat cerebrocortical slices
    K Hirota
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki 036 8563, Japan
    Br J Pharmacol 134:1461-6. 2001
    ..38+/-0.04 (42 mM) and 1240+/-50%, 1.47+/-0.02 (34 mM) and 480+/-10% and 1.40+/-0.05 (40 mM) and 560+/-60% respectively. 6. We conclude that the neuropeptides orexin A and B evoke noradrenaline release from rat cerebrocortical slices...
  35. ncbi Protocol to prevent shoulder-hand syndrome after stroke
    I Kondo
    Department of Rehabilitation Medicine, Institute of Brain Science, Hirosaki University, Japan
    Arch Phys Med Rehabil 82:1619-23. 2001
    ..To determine the effectiveness of a protocol designed to restrict passive movement of affected upper extremity on the incidence of shoulder-hand syndrome (SHS) after stroke...
  36. ncbi Intraoperative prostaglandin E1 improves antimicrobial and inflammatory responses in alveolar immune cells
    N Kotani
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki, Japan
    Crit Care Med 29:1943-9. 2001
    ..We tested the hypothesis that intraoperative prostaglandin E1 (PGE1) suppresses proinflammatory responses and prevents the reduction in antimicrobial responses of alveolar immune cells...
  37. ncbi Vitamin D deficiency and risk of hip fractures among disabled elderly stroke patients
    Y Sato
    Department of Neurology, Kurume University Medical Center, Japan
    Stroke 32:1673-7. 2001
    ..To determine the effects of vitamin D status on hip fracture risk, we prospectively studied a cohort of patients with hemiplegia after stroke who were aged at least 65 years...
  38. ncbi A murine osteosarcoma cell line with a potential to develop ossification upon transplantation
    T Kusumi
    Second Department of Pathology, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Jpn J Cancer Res 92:649-58. 2001
    ..These results suggest that the cell line has the properties of an osteoblastic lineage when cultured in vitro and has an ossifying ability through endochondral bone formation processes when transplanted in vivo...
  39. ncbi Primary non-Hodgkin's lymphoma of the uterine cervix
    Y Yokoyama
    Department of Obstetrics and Gynecology, Hirosaki University School of Medicine, Aomori, Japan
    Arch Gynecol Obstet 265:108-11. 2001
    ..She had a complete remission with a combination of chemotherapy and radiotherapy. Measurement of the serum soluble interleukin-2 receptor level was a useful index of the effectiveness of treatment...
  40. ncbi Adenosine receptor subtypes modulate two major functional pathways for hippocampal serotonin release
    M Okada
    Department of Neuropsychiatry, Hirosaki University, Hirosaki 036 8216, Japan
    J Neurosci 21:628-40. 2001
    ..Therefore, PKA activity plays an important role in the interaction between A1-R and A2-R on hippocampal serotonin release...
  41. ncbi Widespread calcium deposits, as detected using the alizarin red S technique, in the nervous system of rats treated with dimethyl mercury
    F Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Japan
    Neuropathology 20:210-5. 2000
    ..These findings suggest that widespread calcium deposition could occur in the nervous system following dimethyl mercury exposure, and that in the rat the mechanism of calcium deposition differs depending upon the brain region...
  42. ncbi Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain
    F Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Neurosci Lett 285:57-60. 2000
    ..Therefore, RyR expression undergoes dynamic changes during the early postnatal period, when neurons are undergoing structural and functional differentiation...
  43. ncbi Cardiopulmonary bypass produces greater pulmonary than systemic proinflammatory cytokines
    N Kotani
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki, Japan
    Anesth Analg 90:1039-45. 2000
    ..5-3 times greater in alveolar macrophages obtained at the end of surgery than in plasma monocytes obtained simultaneously (P < 0.005). Our data thus suggest that CPB provokes a greater pulmonary than systemic inflammatory response...
  44. ncbi Effect of exhaustive exercise on human neutrophils in athletes
    M Yamada
    Department of Hygiene, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    Luminescence 15:15-20. 2000
    ..05). These data indicated that maximal exercise not only mobilized neutrophils from marginated pools into the circulation, but also caused increased ROS generation...
  45. ncbi Neuropeptides in the livers of mice during bacterial infections
    A Nakane
    Department of Bacteriology, Hirosaki University School of Medicine, Aomori, Japan
    FEMS Immunol Med Microbiol 20:159-64. 1998
    ..However, no SP was detected. In contrast, SP, but not VIP was detected within granulomas in the livers of T. paurometabolum-injected mice, suggesting VIP and SP might be selectively induced in the liver by different bacterial infections...
  46. ncbi Current status of iodine deficiency in Mongolia in 1998-1999
    C Yamada
    Department of Health Sciences, School of Medicine, University of Hirosaki, 66 1 Honcho, Hirosaki 036 08564, Japan
    Asia Pac J Public Health 12:79-84. 2000
    ..However, stronger official commitments and community participation are needed to improve the programme so that iodized salt will be made more widely available...
  47. ncbi Pineal region tumor manifesting initially as hearing impairment
    Md Shafiqul Islam
    Department of Neurosurgery, Hirosaki University School of Medicine, Aomori, Japan
    Neurol Med Chir (Tokyo) 42:301-4. 2002
    ..Hydrocephalus caused conductive deafness by halting or arresting the footplate of stapes movement, as a consequence of high-pressure transmission through the cochlear aqueduct...
  48. ncbi Relationship between salt intake, nitric oxide and asymmetric dimethylarginine and its relevance to patients with end-stage renal disease
    Tomohiro Osanai
    Second Department of Internal Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    Blood Purif 20:466-8. 2002
    ..The results indicate that ADMA is not only a modulator of salt sensitivity in hypertension but also a cardiovascular risk factor in end-stage renal disease...
  49. pmc Effects of various factors on steady-state plasma concentrations of risperidone and 9-hydroxyrisperidone: lack of impact of MDR-1 genotypes
    Norio Yasui-Furukori
    Department of Clinical Pharmacology, Hirosaki University School of Medicine, Hirosaki, Japan
    Br J Clin Pharmacol 57:569-75. 2004
    ..An in vitro study has suggested that risperidone is a substrate of P-glycoprotein, which is coded by MDR-1 gene. Thus, we studied the effects of major polymorphisms of the MDR-1 gene on plasma drug concentrations...
  50. ncbi The prevention of colon carcinogenesis in rats by dietary cellulose is greater than the promotive effect of dietary lard as assessed by repeated endoscopic observation
    Shigeyuki Nakaji
    Department of Hygiene, Hirosaki University School of Medicine, Hirosaki, 036 8562 Japan
    J Nutr 134:935-9. 2004
    ..008), independent of the lard concentration. These results suggest that the preventive effect of cellulose against large bowel tumorigenesis is greater than the promotive effect of fat under the current experimental conditions...
  51. ncbi Nitric oxide generation and poly(ADP ribose) polymerase activation precede beta-cell death in rats with a single high-dose injection of streptozotocin
    Ryuichi Wada
    Department of Pathology, Hirosaki University School of Medicine, 5 Zaifu cho, 036 8562, Hirosaki, Japan
    Virchows Arch 444:375-82. 2004
    ..The current study documented serial processes of STZ-induced beta-cell death, starting with NO generation and PARP activation followed by a clearance with macrophages, where the activation of PARP plays a central role in beta-cell death...
  52. ncbi Effect of shear stress on asymmetric dimethylarginine release from vascular endothelial cells
    Tomohiro Osanai
    Second Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562 Japan
    Hypertension 42:985-90. 2003
    ..Shear stress at higher magnitudes facilitates the degradation of ADMA, thus returning ADMA release levels to baseline...
  53. ncbi Thrombolytic therapy for delayed, in-hospital stroke after cardiac surgery
    Ikuo Fukuda
    Department of Surgery I, Hirosaki University School of Medicine, Hirosaki, Aomori, Japan
    Ann Thorac Surg 76:1293-5. 2003
    ..All patients survived with moderate or full functional recovery. Immediate cerebral angiography and local thrombolysis may improve functional outcome and survival in patients with postcardiotomy cerebral thromboembolism...
  54. ncbi Alpha-synuclein accumulates in Purkinje cells in Lewy body disease but not in multiple system atrophy
    Fumiaki Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    J Neuropathol Exp Neurol 62:812-9. 2003
    ..No such inclusions were observed in MSA, tauopathies, or controls. These findings indicate that Purkinje cells are also the victims of a-synuclein pathology in PD and DLB, but not in MSA...
  55. ncbi Interleukin-1 induces tau phosphorylation and morphological changes in cultured human astrocytes
    Kunikazu Tanji
    Department of Molecular Biology, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Neuroreport 14:413-7. 2003
    ..The early tau phosphorylation induced by IL-1alpha might create a plastic environment for morphological changes in astrocytes...
  56. pmc Vascular endothelial growth factor-D is an independent prognostic factor in epithelial ovarian carcinoma
    Y Yokoyama
    Department of Obstetrics and Gynaecology, University of Cambridge, The Rose Maternity Hospital, UK
    Br J Cancer 88:237-44. 2003
    ..Since VEGF-D was found to be an independent predictor of poor outcome, its measurement, together with other prognostic markers may improve prospective identification of patients with a poor prognosis...
  57. ncbi Disseminated candidiasis following prednisolone therapy in systemic lupus erythematosus
    Hiroshi Tanaka
    Department of Pediatrics, Hirosaki University, School of Medicine, Hirosaki, Japan
    Pediatr Int 44:702-4. 2002
  58. ncbi 15-Deoxy-D12,14-prostaglandin J2 inhibits CX3CL1/fractalkine expression in human endothelial cells
    Tadaatsu Imaizumi
    Departments of Vascular Biology, Hirosaki University School of Medicine, Japan
    Immunol Cell Biol 80:531-6. 2002
    ..The data suggest that 15d-PGJ2 regulates inflammatoryreactions, at least in part, through the inhibition of fractalkineexpression and leucocyte traffic through the endothelium...
  59. ncbi Genetic identifiers of epilepsy
    Sunao Kaneko
    Department of Neuropsychiatry, Hirosaki University, Hirosaki, Japan
    Epilepsia 43:16-20. 2002
    ..Pathogenesis of epilepsy as a channelopathy and of BFNC also is discussed...
  60. ncbi Axonal injury in auditory nerve observed in reversible latency changes of brainstem auditory evoked potentials (BAEP) during cerebellopontine angle manipulations in rats
    Tetsuji Sekiya
    Department of Neurosurgery, Hirosaki University School of Medicine, 5 Zaifu cho, Japan
    Hear Res 173:91-9. 2002
    ..Changes in the amplitude of wave V of BAEP appears to be more sensitive than its latency change as an intraoperative indicator for axonal injury in the auditory nerve...
  61. ncbi Comparison of etiology of right-sided diverticula in Japan with that of left-sided diverticula in the West
    Shigeyuki Nakaji
    Department of Hygiene, Hirosaki University School of Medicine, Zaifu cho 5, Hirosaki, 036 8562 Japan
    Int J Colorectal Dis 17:365-73. 2002
    ..This study compared the etiology of right-sided diverticula in Japan with that of left-sided diverticula in the West...
  62. ncbi Aspartate is enriched in sensory cells and subpopulations of non-neuronal cells in the guinea pig inner ear: a quantitative immunoelectron microscopic analysis
    S Usami
    Department of Otorhinolaryngology, Hirosaki University School of Medicine, Japan
    Brain Res 742:43-9. 1996
    ..The present immunocytochemical results are consistent with the idea that aspartate is involved in neurotransmission in the inner ear, but also point to possible metabolic roles of aspartate...