Affiliation: Health Sciences University of Hokkaido
Suzuki Y. Role of IGFBPs in the morphogenesis of lingual papillae. Anat Rec A Discov Mol Cell Evol Biol. 2005;286:841-7 pubmed
..As previously suggested from a study on postnatal mice (Suzuki et al. J Comp Neurol 2005;482:74-84), IGFBP-4 acts in the epithelial invagination to form the trenches, grooves, or furrows of lingual papillae during development. ..
Suzuki Y, Takeda M, Obara N. Expression of NeuroD in the mouse taste buds. Cell Tissue Res. 2002;307:423-8 pubmed
..These results suggest that NeuroD is expressed in a mature cell type, type-II cells, but not in type-III cells. ..
Suzuki Y, Mizoguchi I, Nishiyama H, Takeda M, Obara N. Expression of Hes6 and NeuroD in the olfactory epithelium, vomeronasal organ and non-sensory patches. Chem Senses. 2003;28:197-205 pubmed
..At P3-P7, expression of NeuroD and Hes6 disappeared in the region corresponding to the presumptive non-sensory patches. The loss of these genes may stop the differentiation and may cause apoptosis of GBCs and ORNs. ..
Suzuki Y, Tsuruga E, Yajima T, Takeda M. Expression of bHLH transcription factors NSCL1 and NSCL2 in the mouse olfactory system. Chem Senses. 2003;28:603-8 pubmed
..Moreover, the temporal pattern of expression suggests that NSCL1 and NSCL2 may function during development rather than in the adult stage...
Suzuki Y. Expression of Sox2 in mouse taste buds and its relation to innervation. Cell Tissue Res. 2008;332:393-401 pubmed publisher
..Sox2-IR cells were found in the populations of basal cells and of immature and some mature taste bud cells. A large number of Sox2-IR cells were identified as type-I cells, with a few being type-II and type-III cells. ..
Suzuki Y, Ikeda K, Kawakami K. Regulatory role of Six1 in the development of taste papillae. Cell Tissue Res. 2010;339:513-25 pubmed publisher
..Thus, the modulation of signaling events in Six1 ( -/- ) leads to the earlier formation of the gustatory papillae, the abnormal distribution of fungiform papillae, and malformed trenches in circumvallate and foliate papillae. ..
Suzuki Y, Ikeda K, Kawakami K. Expression of Six1 and Six4 in mouse taste buds. J Mol Histol. 2010;41:205-14 pubmed publisher
..These results suggest that Six1 and Six4 genes are expressed in the taste bud cells, in newly formed or surviving type-II cells. ..
Suzuki Y, Ikeda K, Kawakami K. Development of gustatory papillae in the absence of Six1 and Six4. J Anat. 2011;219:710-21 pubmed publisher
..The foliate papillae elevated initially, and showed stunted trenches. Therefore, Six1 and Six4 function synergistically to form gustatory papillae during development of the tongue. ..