Tetsuya Endo

Summary

Affiliation: Health Sciences University of Hokkaido
Country: Japan

Publications

  1. ncbi request reprint Mercury and selenium concentrations in the internal organs of toothed whales and dolphins marketed for human consumption in Japan
    Tetsuya Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757, Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Sci Total Environ 300:15-22. 2002
  2. doi request reprint Carbon and nitrogen stable isotope ratios and mercury concentration in the scalp hair of residents from Taiji, a whaling town
    Tetsuya Endo
    School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Mar Pollut Bull 69:116-21. 2013
  3. doi request reprint Levels of mercury in muscle and liver of star-spotted dogfish (Mustelus manazo) from the northern region of Japan: a comparison with spiny dogfish (Squalus acanthias)
    Tetsuya Endo
    Faculty of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757, Ishikari Tobetsu, Hokkaido, 061 0293, Japan
    Arch Environ Contam Toxicol 64:467-74. 2013
  4. ncbi request reprint Levels of mercury and organohalogen compounds in the muscle and liver of kidako moray eels (Gymnothorax kidako) caught off the southern region of Japan
    Tetsuya Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Biol Pharm Bull 35:1745-51. 2012
  5. doi request reprint Stable isotope ratios and mercury levels in red meat products from baleen whales sold in Japanese markets
    Tetsuya Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757, Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Ecotoxicol Environ Saf 79:35-41. 2012
  6. ncbi request reprint Distribution of total mercury, methyl mercury and selenium in pod of killer whales (Orcinus Orca) stranded in the northern area of Japan: comparison of mature females with calves
    Tetsuya Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Environ Pollut 144:145-50. 2006
  7. ncbi request reprint Effects of P-glycoprotein inhibitors on cadmium accumulation in cultured renal epithelial cells, LLC-PK1, and OK
    Tetsuya Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757, Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Toxicol Appl Pharmacol 185:166-71. 2002
  8. ncbi request reprint Renal toxicity in rats after oral administration of mercury-contaminated boiled whale livers marketed for human consumption
    Tetsuya Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Arch Environ Contam Toxicol 44:412-6. 2003
  9. ncbi request reprint pH-dependent transport of cadmium in rat renal brush border membrane vesicles: cadmium efflux via H+-antiport
    T Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan
    Toxicol Lett 99:99-107. 1998
  10. ncbi request reprint Mercury contamination in the red meat of whales and dolphins marketed for human consumption in Japan
    T Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757, Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Environ Sci Technol 37:2681-5. 2003

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Mercury and selenium concentrations in the internal organs of toothed whales and dolphins marketed for human consumption in Japan
    Tetsuya Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757, Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Sci Total Environ 300:15-22. 2002
    ..15 g of liver exceeds the PTWI of 60 kg of body weight of the consumer, suggesting the possibility of an acute intoxication by T-Hg even after a single consumption of the product...
  2. doi request reprint Carbon and nitrogen stable isotope ratios and mercury concentration in the scalp hair of residents from Taiji, a whaling town
    Tetsuya Endo
    School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Mar Pollut Bull 69:116-21. 2013
    ..The consumption of whale meat may increase Hg concentration as well as δ(15)N and δ(13)C values in scalp hair...
  3. doi request reprint Levels of mercury in muscle and liver of star-spotted dogfish (Mustelus manazo) from the northern region of Japan: a comparison with spiny dogfish (Squalus acanthias)
    Tetsuya Endo
    Faculty of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757, Ishikari Tobetsu, Hokkaido, 061 0293, Japan
    Arch Environ Contam Toxicol 64:467-74. 2013
    ..Chemosphere 77:1333-1337, 2009). The greater lipid content in liver and the larger liver size in spiny dogfish may explain the much lower levels of Hg observed in liver of spiny dogfish compared with those in the star-spotted dogfish...
  4. ncbi request reprint Levels of mercury and organohalogen compounds in the muscle and liver of kidako moray eels (Gymnothorax kidako) caught off the southern region of Japan
    Tetsuya Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Biol Pharm Bull 35:1745-51. 2012
    ..The δ(13)C and δ(15)N values in the kidako moray eel were markedly higher than those in offshore habit predators reported elsewhere, which may reflect the inshore habitat of this eels...
  5. doi request reprint Stable isotope ratios and mercury levels in red meat products from baleen whales sold in Japanese markets
    Tetsuya Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757, Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Ecotoxicol Environ Saf 79:35-41. 2012
    ....
  6. ncbi request reprint Distribution of total mercury, methyl mercury and selenium in pod of killer whales (Orcinus Orca) stranded in the northern area of Japan: comparison of mature females with calves
    Tetsuya Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Environ Pollut 144:145-50. 2006
    ..In contrast, contamination level of T-Hg in the calf organs was much lower than that in the mature female organs. These results suggest that the transfer of Hg from the mother to the fetus via placenta and/or to calf via milk is trace...
  7. ncbi request reprint Effects of P-glycoprotein inhibitors on cadmium accumulation in cultured renal epithelial cells, LLC-PK1, and OK
    Tetsuya Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757, Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Toxicol Appl Pharmacol 185:166-71. 2002
    ..These results suggest that P-gp in LLC-PK(1) and OK cells appear to act as an efflux pump of Cd, decreasing cellular Cd accumulation...
  8. ncbi request reprint Renal toxicity in rats after oral administration of mercury-contaminated boiled whale livers marketed for human consumption
    Tetsuya Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Arch Environ Contam Toxicol 44:412-6. 2003
    ..These data indicate that the human consumption of boiled whale liver may cause acute intoxication by the contaminated inorganic mercury...
  9. ncbi request reprint pH-dependent transport of cadmium in rat renal brush border membrane vesicles: cadmium efflux via H+-antiport
    T Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan
    Toxicol Lett 99:99-107. 1998
    ..These findings suggest that the outwardly directed H+-gradient increases the Cd efflux across the renal brush border membrane via H+-antiport system...
  10. ncbi request reprint Mercury contamination in the red meat of whales and dolphins marketed for human consumption in Japan
    T Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757, Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Environ Sci Technol 37:2681-5. 2003
    ..On the other hand, T-Hg concentrations in all mystecete red meat samples except for one (0.01-0.54 microg/ wet g, n = 62) were below the permitted level of T-Hg, probably reflecting their lower trophic levels...
  11. ncbi request reprint Distribution and toxicity of mercury in rats after oral administration of mercury-contaminated whale red meat marketed for human consumption
    T Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Chemosphere 61:1069-73. 2005
    ..The occasional consumption of red meat from small cetaceans, therefore, could pose a health problem for not only pregnant women but also for the general population...
  12. ncbi request reprint Contamination by mercury and cadmium in the cetacean products from Japanese market
    T Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757, Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Chemosphere 54:1653-62. 2004
    ..Cadmium contamination levels in boiled liver, kidney and lung were 8.59+/-12.0, 10.4+/-8.6 and 1.66+/-1.27 (microg/wetg), respectively...
  13. ncbi request reprint Total mercury, methyl mercury, and selenium levels in the red meat of small cetaceans sold for human consumption in Japan
    Tetsuya Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Environ Sci Technol 39:5703-8. 2005
    ..The consumption of red meat from small cetaceans, therefore, could pose a health problem for not only pregnant women but also for the general population...
  14. ncbi request reprint Age-dependent accumulation of heavy metals in a pod of killer whales (Orcinus orca) stranded in the northern area of Japan
    Tetsuya Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Chemosphere 67:51-9. 2007
    ....
  15. ncbi request reprint Contamination level of mercury in red meat products from cetaceans available from South Korea markets
    Tetsuya Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Mar Pollut Bull 54:669-77. 2007
    ..Pregnant women and other vulnerable sectors of the population living in South Korea should therefore limit their consumption of odontocete products...
  16. doi request reprint Contamination levels of mercury and cadmium in melon-headed whales (Peponocephala electra) from a mass stranding on the Japanese coast
    Tetsuya Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Sci Total Environ 401:73-80. 2008
    ..05 microg/wet g). These results suggest that the formation of Hg-Se compounds mainly occurs in the liver after the demethylation of M-Hg, and Cd preferentially accumulates in the kidney of melon-headed whales...
  17. ncbi request reprint Bidirectional transport of cadmium across apical membrane of renal epithelial cell lines via H+-antiporter and inorganic anion exchanger
    T Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari Tobetsu, Japan
    Toxicology 131:183-92. 1998
    ..5. These results suggest bidirectional transport of Cd across the apical membrane of renal epithelial cells via a H+-antiport system (efflux) and an inorganic anion exchanger (influx), depending on the pH of the apical side...
  18. ncbi request reprint Further analysis of cadmium uptake from apical membrane of LLC-PK1 cells via inorganic anion exchanger
    T Endo
    Faculty of Pharmaceutical Sciences, Health Sciences, University of Hokkaido, Japan
    Pharmacol Toxicol 84:187-92. 1999
    ....
  19. ncbi request reprint Carrier-mediated uptake of cisplatin by the OK renal epithelial cell line
    T Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Ishikari Tobetsu, Hokkaido, Japan
    Toxicology 146:187-95. 2000
    ..These results suggest that the uptake and basolateral-to-apical transport of cisplatin are mediated by not only simple diffusion but also by the organic cation transport system...
  20. ncbi request reprint Secretory transport of cadmium through intestinal brush border membrane via H(+)-antiport
    T Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757, Ishikari Tobetsu, 061 0293, Hokkaido, Japan
    Toxicology 150:129-36. 2000
    ..These findings suggest the secretory transport of Cd through the intestinal brush border membrane not only via passive diffusion but also via H(+)-antiport of the putative organic cation transporter...
  21. doi request reprint Stable isotope ratios of carbon and nitrogen and mercury concentrations in 13 toothed whale species taken from the western Pacific Ocean off Japan
    Tetsuya Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari Tobetsu, Hokkaido, Japan
    Environ Sci Technol 44:2675-81. 2010
    ..Spatial variations in partial differential(13)C, partial differential(15)N, and T-Hg concentrations in the ocean may be the cause of these phenomena...
  22. doi request reprint High mercury levels in hair samples from residents of Taiji, a Japanese whaling town
    Tetsuya Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Mar Pollut Bull 60:743-7. 2010
    ..The T-Hg level found in the Taiji whale meat consumers was markedly higher than that observed in the Japanese population overall (about 2 microg/g)...
  23. doi request reprint Contamination levels of mercury in the muscle of female and male spiny dogfishes (Squalus acanthias) caught off the coast of Japan
    Tetsuya Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Chemosphere 77:1333-7. 2009
    ..3+/-0.4 per thousand and 12.4+/-0.8 per thousand, respectively). A positive correlation was found between partial differential(13)C and partial differential(15)N values, suggesting trophic enrichment due to the growth...
  24. doi request reprint Hg, Zn and Cu levels in the muscle and liver of tiger sharks (Galeocerdo cuvier) from the coast of Ishigaki Island, Japan: relationship between metal concentrations and body length
    Tetsuya Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Mar Pollut Bull 56:1774-80. 2008
    ..The high concentrations of the essential metals Zn and Cu in immature sharks may be explained by the physiological demands related to rapid growth...
  25. ncbi request reprint Effects of P-glycoprotein inhibitors on transepithelial transport of cadmium in cultured renal epithelial cells, LLC-PK1 and LLC-GA5-COL 150
    Osamu Kimura
    Clinical Toxicology and Metabolism, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Kanazawa, 1757 Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Toxicology 208:123-32. 2005
    ..These results suggest that Cd is extruded from the apical membrane of LLC-PK(1) and LLC-GA5-COL 150 cells, probably depending on the level of P-gp expression...
  26. doi request reprint Uptake of triclopyr (3,5,6-trichloro-2-pyridinyloxyacetic acid) and dicamba (3,6-dichloro-2-methoxybenzoic acid) from the apical membranes of the human intestinal Caco-2 cells
    Osamu Kimura
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari Tobetsu, Japan
    Arch Toxicol 86:55-61. 2012
    ..The uptake of dicamba appears to be mediated mainly via passive diffusion, which is in contrast to the uptake of benzoic acid via MCTs. We speculate that the substituted groups in dicamba may inhibit uptake via MCTs...
  27. doi request reprint Levels of mercury and organochlorine compounds and stable isotope ratios in three tuna species taken from different regions of Japan
    Yohsuke Hisamichi
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Environ Sci Technol 44:5971-8. 2010
    ....
  28. doi request reprint Transepithelial transport of 4-chloro-2-methylphenoxyacetic acid (MCPA) across human intestinal Caco-2 cell monolayers
    Osamu Kimura
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Hokkaido, Japan
    Basic Clin Pharmacol Toxicol 110:530-6. 2012
    ....
  29. doi request reprint Levels of mercury and organohalogen compounds in Pacific bluefin tuna (Thunnus orientalis) cultured in different regions of Japan
    Yohsuke Hisamichi
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Kanazawa, Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Arch Environ Contam Toxicol 62:296-305. 2012
    ..Thus, contamination levels of T-Hg, p,p'-DDE, and PCBs in the cultured tuna may reflect contamination levels not only in the marine environment but also in prey fish used as bait...
  30. ncbi request reprint 5-Hydroxytryptamine (5-HT)-induced depolarization in isolated abdominal vagus nerves in the rat: involvement of 5-HT3 and 5-HT4 receptors
    M Nemoto
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan
    Res Commun Mol Pathol Pharmacol 109:217-30. 2001
    ..These findings suggest that this electrophysiological method for evaluating isolated abdominal vagus nerve depolarization is a useful technique for the estimation of 5-HT-induced depolarization...
  31. doi request reprint Uptake of phenoxyacetic acid derivatives into Caco-2 cells by the monocarboxylic acid transporters
    Osamu Kimura
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Toxicol Lett 189:102-9. 2009
    ....
  32. ncbi request reprint Transport of cadmium across the apical membrane of epithelial cell lines
    Tetsuya Endo
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757, Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Comp Biochem Physiol C Toxicol Pharmacol 131:223-9. 2002
    ..In addition, passive diffusion of Cd appears to be decreased by low temperature and a decrease in pH...
  33. ncbi request reprint Functional roles of 5-hydroxytryptamine 3/4 receptors in neurons of rat dorsal motor nucleus of the vagus
    E Fukushi
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido 1757, Kanazawa, Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Neuroscience 141:675-85. 2006
    ....
  34. doi request reprint Carrier-mediated uptake of nobiletin, a citrus polymethoxyflavonoid, in human intestinal Caco-2 cells
    Osamu Kimura
    School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Kanazawa, Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Food Chem 154:145-50. 2014
    ..These results suggest that uptake of NBL from the apical membranes of Caco-2 cells is mainly mediated by an energy-independent facilitated diffusion process. ..
  35. ncbi request reprint Uptake of 4-chloro-2-methylphenoxyacetic acid (MCPA) from the apical membrane of Caco-2 cells by the monocarboxylic acid transporter
    Osamu Kimura
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Toxicol Appl Pharmacol 227:325-30. 2008
    ..These results suggest that the uptake of MCPA from the apical membrane of Caco-2 cells is mainly mediated by common MCTs along with benzoic acid but also in part by l-lactic acid...
  36. doi request reprint Transcellular transport of domoic acid across intestinal Caco-2 cell monolayers
    Osamu Kimura
    Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Food Chem Toxicol 49:2167-71. 2011
    ..These results suggest that the apical-to-basolateral transport of DA across the Caco-2 cell monolayers is mediated by DIDS-sensitive anion transporters...
  37. ncbi request reprint The effects of nabumetone, a cyclooxygenase-2 inhibitor, on cisplatin-induced 5-hydroxytryptamine release from the isolated rat ileum
    C Kudo
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan
    Res Commun Mol Pathol Pharmacol 110:117-32. 2001
    ..On the other hand, there is a possibility that dexamethasone works through a mechanism other than 5-HT release in delayed emesis...
  38. ncbi request reprint Antiemetic effects of sendide, a peptide tachykinin NK1 receptor antagonist, in the ferret
    M Minami
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari Tobetsu, Japan
    Eur J Pharmacol 363:49-55. 1998
    ..3%, P < 0.05). Since sendide does not penetrate the central nervous system, these results suggest that the antiemetic effects of sendide are due to the inhibition of NK1 and 5-HT3 receptors on the emetic peripheral detector sites...
  39. ncbi request reprint Noradrenaline stimulates 5-hydroxytryptamine release from mouse ileal tissues via alpha(2)-adrenoceptors
    M Hirafuji
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Eur J Pharmacol 432:149-52. 2001
    ..v.) for 2 days. These results suggest that noradrenaline causes 5-HT release from enterochromaffin cells in mouse ileal tissues via alpha(2)-adrenoceptor subtypes coupled to a pertussis toxin-sensitive G protein...
  40. ncbi request reprint Effects of CP-99, 994, a tachykinin NK(1) receptor antagonist, on abdominal afferent vagal activity in ferrets: evidence for involvement of NK(1) and 5-HT(3) receptors
    M Minami
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Kanazawa, Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Eur J Pharmacol 428:215-20. 2001
    ..g. modulation of 5-HT release or reduction of local inflammatory response) to the antiemetic effects of CP-99, 994 against cisplatin and other emetic agents acting primarily via the vagus...
  41. ncbi request reprint Neurochemistry and neuropharmacology of emesis - the role of serotonin
    T Endo
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757, Ishikari Tobetsu, 061 0293, Hokkaido, Japan
    Toxicology 153:189-201. 2000
    ..This vagal afferent nerve depolarization may evoke the vomiting reflex. This review describes the role of 5-HT in anticancer drug-induced emesis from the viewpoint of 5-HT release from EC cells and afferent vagus nerve activity...
  42. ncbi request reprint Inhibition by docosahexaenoic acid of receptor-mediated Ca(2+) influx in rat vascular smooth muscle cells stimulated with 5-hydroxytryptamine
    M Hirafuji
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Eur J Pharmacol 427:195-201. 2001
    ..These results suggest that the specific inhibition of intracellular Ca(2+) dynamics in vascular smooth muscle cells may contribute to the beneficial properties of docosahexaenoic acid on cardiovascular disorders...
  43. ncbi request reprint Effects of extract of Ginkgo biloba leaves and its constituents on carcinogen-metabolizing enzyme activities and glutathione levels in mouse liver
    Keiko Sasaki
    Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari Tobetsu, Japan
    Life Sci 70:1657-67. 2002
    ....
  44. ncbi request reprint A mixture of organisms affects cholesterol metabolism together with rat cecal flora
    M Fukushima
    Department of Bioresource Science, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan
    Biosci Biotechnol Biochem 63:1160-4. 1999
    ....
  45. ncbi request reprint Successful treatment with rituximab for autoimmune hemolytic anemia concomitant with proliferation of Epstein-Barr virus and monoclonal gammopathy in a post-nonmyeloablative stem cell transplant patient
    T Endo
    Department of Internal Medicine II, Hokkaido University School of Medicine, N 15, W 7, Kita ku, 060 8638, Sapporo, Hokkaido, Japan
    Ann Hematol 83:114-6. 2004
    ..Rituximab therapy deserves consideration for treatment of post-allogeneic stem cell transplant patients with AIHA, especially for patients who cannot be given immunosuppressive therapy...
  46. ncbi request reprint Identification, quantification, and synthesis of a novel dimethoxylated polybrominated biphenyl in marine mammals caught off the coast of Japan
    Göran Marsh
    Department of Environmental Chemistry, Stockholm University, SE 106 91 Stockholm, Sweden
    Environ Sci Technol 39:8684-90. 2005
    ..To obtain the necessary authentic standards, synthesis was performed of 2,2'-diMeO-BB80 and the known natural product 2',6-dimethoxy-2,3',4,5'-tetrabromodiphenyl ether (2',6-diMeO-BDE68)...
  47. ncbi request reprint Expression of MMP-9 in mesangial cells and its changes in anti-GBM glomerulonephritis in WKY rats
    Tadahide Kuroda
    Department of Structural Pathology, Institute of Nephrology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    Clin Exp Nephrol 8:206-15. 2004
    ....
  48. ncbi request reprint Vertebrate limb regeneration and the origin of limb stem cells
    Susan V Bryant
    Developmental Biology Center and Department of Developmental and Cell Biology, University of California, Irvine 92697 2275, USA
    Int J Dev Biol 46:887-96. 2002
    ..Advances in regeneration research will then feed back in terms of devising new strategies for therapies to induce regeneration in organisms such as humans that have traditionally been viewed as incapable of regeneration...
  49. ncbi request reprint Amphidinin B, a new polyketide metabolite from marine dinoflagellate Amphidinium sp
    Takaaki Kubota
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    J Antibiot (Tokyo) 59:512-6. 2006
    ..A new polyketide metabolite, amphidinin B (1), has been isolated from a marine dinoflagellate Amphidinium sp. and the structure and absolute stereochemistry were elucidated on the basis of spectroscopic data and chemical means...
  50. ncbi request reprint Studies on intestinal absorption of sulpiride (1): carrier-mediated uptake of sulpiride in the human intestinal cell line Caco-2
    Kazuhiro Watanabe
    Hokkaido College of Pharmacy, Otaru, Japan
    Biol Pharm Bull 25:885-90. 2002
    ..From these findings, we presumed that peptide transporter PEPT1 and organic cation transporters OCTN1 and OCTN2 are involved with this uptake. P-glycoprotein may also contribute to the efflux of sulpiride...
  51. ncbi request reprint Hemolytic crisis with fulminant hepatic failure in Wilson disease without consanguinity
    Junichi Kitazawa
    Department of Pediatrics, Hirosaki City Hospital, Aomori, Japan
    Pediatr Int 46:726-9. 2004