Keizo Kohno

Summary

Affiliation: Hayashibara Biochemical Laboratories
Country: Japan

Publications

  1. ncbi request reprint Effects of dietary lactosucrose (4G-beta-D-galactosylsucrose) on the IgE response in mice
    Yoshifumi Taniguchi
    Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc Okayama 702 8006, Japan
    Biosci Biotechnol Biochem 71:2766-73. 2007
  2. ncbi request reprint IL-18 prevents the development of chronic graft-versus-host disease in mice
    I Okamoto
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    J Immunol 164:6067-74. 2000
  3. ncbi request reprint Anti-inflammatory and immunomodulatory properties of 2-amino-3H-phenoxazin-3-one
    Keizo Kohno
    Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    Biol Pharm Bull 31:1938-45. 2008
  4. ncbi request reprint Royal jelly inhibits the production of proinflammatory cytokines by activated macrophages
    Keizo Kohno
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    Biosci Biotechnol Biochem 68:138-45. 2004
  5. ncbi request reprint Major royal jelly protein 3 modulates immune responses in vitro and in vivo
    Iwao Okamoto
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, 702 8006 Okayama, Japan
    Life Sci 73:2029-45. 2003
  6. ncbi request reprint Effect of AgK114 on picryl chloride-induced chronic contact hypersensitivity responses
    Chikako Arai
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    In Vivo 20:347-51. 2006
  7. ncbi request reprint The flavonoid Kaempferol suppresses the graft-versus-host reaction by inhibiting type 1 cytokine production and CD8+ T cell engraftment
    Iwao Okamoto
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Incorporated, Japan
    Clin Immunol 103:132-44. 2002
  8. ncbi request reprint Oral administration of royal jelly inhibits the development of atopic dermatitis-like skin lesions in NC/Nga mice
    Yoshifumi Taniguchi
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, Fujisaki 675 1, Okayama 702 8006, Japan
    Int Immunopharmacol 3:1313-24. 2003
  9. ncbi request reprint Antitumor activity of interleukin-18 against the murine T-cell leukemia/lymphoma EL-4 in syngeneic mice
    Sachiko Akamatsu
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    J Immunother 25:S28-34. 2002
  10. ncbi request reprint Lactosucrose inhibits body fat accumulation in rats by decreasing intestinal lipid absorption
    Akiko Mizote
    Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    Biosci Biotechnol Biochem 73:582-7. 2009

Collaborators

  • Kanso Iwaki
  • Yoshifumi Taniguchi
  • Kazuyuki Oku
  • Shigeyuki Arai
  • Tetsuya Mori
  • Hikaru Watanabe
  • H Ikegami
  • Shigeharu Fukuda
  • Chikako Arai
  • Akiko Mizote
  • Toshio Kunikata
  • Shimpei Ushio
  • Norie Arai
  • Masao Ikeda
  • Masashi Kurimoto
  • Iwao Okamoto
  • Osamu Sano
  • Mutsuko Taniguchi
  • Masaki Miyake
  • Mayumi Kurose
  • Hiroto Chaen
  • Shin Ichiro Inoue
  • Tsunetaka Ohta
  • Toshiharu Hanaya
  • Mitsukiyo Fujii
  • Keiko Hino
  • Tomoki Tatefuji
  • Satomi Koya-Miyata
  • Tadao Tanimoto
  • Sachiko Akamatsu
  • Simpei Ushio
  • I Okamoto
  • Shigeto Yamamoto
  • Yasuhiko Takei
  • Takeo Sakurai
  • Mark J Micallef
  • T Ishihara
  • S Akamatsu
  • M Kurimoto
  • T Tanimoto

Detail Information

Publications18

  1. ncbi request reprint Effects of dietary lactosucrose (4G-beta-D-galactosylsucrose) on the IgE response in mice
    Yoshifumi Taniguchi
    Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc Okayama 702 8006, Japan
    Biosci Biotechnol Biochem 71:2766-73. 2007
    ..Our findings indicate the further possibility that dietary LS supplementation can be used to prevent IgE-mediated allergic diseases...
  2. ncbi request reprint IL-18 prevents the development of chronic graft-versus-host disease in mice
    I Okamoto
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    J Immunol 164:6067-74. 2000
    ..Thus, our results suggest that IL-18 has beneficial effects in the prevention and treatment of chronic GVHD...
  3. ncbi request reprint Anti-inflammatory and immunomodulatory properties of 2-amino-3H-phenoxazin-3-one
    Keizo Kohno
    Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    Biol Pharm Bull 31:1938-45. 2008
    ....
  4. ncbi request reprint Royal jelly inhibits the production of proinflammatory cytokines by activated macrophages
    Keizo Kohno
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    Biosci Biotechnol Biochem 68:138-45. 2004
    ..Thus, our results suggest that RJ has anti-inflammatory actions through inhibiting proinflammatory cytokine production by activated macrophages...
  5. ncbi request reprint Major royal jelly protein 3 modulates immune responses in vitro and in vivo
    Iwao Okamoto
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, 702 8006 Okayama, Japan
    Life Sci 73:2029-45. 2003
    ..Furthermore, considering the intriguing immunomodulatory effects of MRJP3, it may be of clinical significance to design MRJP3-derived antiallergic peptides by identifying the associated polypeptide regions...
  6. ncbi request reprint Effect of AgK114 on picryl chloride-induced chronic contact hypersensitivity responses
    Chikako Arai
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    In Vivo 20:347-51. 2006
    ..In this study, the effects of AgK114 on the systemic immune response were examined in contact hypersensitivity (CHS) model mice...
  7. ncbi request reprint The flavonoid Kaempferol suppresses the graft-versus-host reaction by inhibiting type 1 cytokine production and CD8+ T cell engraftment
    Iwao Okamoto
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Incorporated, Japan
    Clin Immunol 103:132-44. 2002
    ..Thus, our study indicates that Kaempferol has the capacity to modulate the Th1/Th2 balance and could be useful for the treatment of cell-mediated immune diseases, such as acute GVHD...
  8. ncbi request reprint Oral administration of royal jelly inhibits the development of atopic dermatitis-like skin lesions in NC/Nga mice
    Yoshifumi Taniguchi
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, Fujisaki 675 1, Okayama 702 8006, Japan
    Int Immunopharmacol 3:1313-24. 2003
    ..Thus, our results suggest that RJ suppresses the development of AD-like skin lesions in PiCl-treated NC/Nga mice, possibly by a combination of down-regulating TNP-specific IFN-gamma production and up-regulating iNOS expression...
  9. ncbi request reprint Antitumor activity of interleukin-18 against the murine T-cell leukemia/lymphoma EL-4 in syngeneic mice
    Sachiko Akamatsu
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    J Immunother 25:S28-34. 2002
    ..These results suggest that antitumor efficacy of IL-18 is mediated primarily by NK cells, but that T cells are also required for the complete antitumor efficacy of IL-18...
  10. ncbi request reprint Lactosucrose inhibits body fat accumulation in rats by decreasing intestinal lipid absorption
    Akiko Mizote
    Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    Biosci Biotechnol Biochem 73:582-7. 2009
    ..Thus, LS may reduce adipose tissue accumulation by inhibiting intestinal lipid absorption via a direct interaction with TG...
  11. doi request reprint Trehalose prevents adipocyte hypertrophy and mitigates insulin resistance
    Chikako Arai
    Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    Nutr Res 30:840-8. 2010
    ..These findings further suggest that trehalose is a functional saccharide that mitigates insulin resistance...
  12. ncbi request reprint Characterization of royal jelly proteins in both Africanized and European honeybees (Apis mellifera) by two-dimensional gel electrophoresis
    Osamu Sano
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    J Agric Food Chem 52:15-20. 2004
    ..Thus, the results suggest that two-dimensional gel electrophoresis provides a suitable method for the qualitative analysis of the proteins contained in RJ derived from different honeybee species...
  13. ncbi request reprint Inhibitory effects of 2-amino-3H-phenoxazin-3-one on the melanogenesis of murine B16 melanoma cell line
    Masaki Miyake
    Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    Biosci Biotechnol Biochem 74:753-8. 2010
    ..These results suggest that APO is a promising depigmenting agent with both therapeutic and cosmetic value in preventing melanogenesis...
  14. doi request reprint Tryptanthrin inhibits Th2 development, and IgE-mediated degranulation and IL-4 production by rat basophilic leukemia RBL-2H3 cells
    Kanso Iwaki
    Drugs, Cosmetics and Chemicals Development Center, Hayashibara Biochemical Laboratories, Inc, Japan
    J Ethnopharmacol 134:450-9. 2011
    ..Tryptanthrin is a compound isolated from Polygonum tinctorium, which is a known folk medicine with various biological activities...
  15. ncbi request reprint [Activation of natural killer T cells by NK-4, a criptocyanine dye]
    Toshio Kunikata
    Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    Yakugaku Zasshi 131:1667-74. 2011
    ....
  16. ncbi request reprint mAgK114 suppresses lymphocyte infiltration into epidermis in the picryl chloride-induced atopic dermatitis-like skin lesions of NC/Nga mice
    Chikako Arai
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    In Vivo 20:77-83. 2006
    ..This suggests that mAgK114 has an important effect on skin wound repairing...
  17. doi request reprint Anti-oxidative and anti-aging activities of 2-O-α-glucopyranosyl-L-ascorbic acid on human dermal fibroblasts
    Mutsuko Taniguchi
    Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, Naka ku, Okayama 702 8006, Japan
    Eur J Pharmacol 674:126-31. 2012
    ..Together, these results suggest that AA-2G protects dermal fibroblasts from oxidative stress and cellular senescence. These characteristics indicate that AA-2G could become a promising material for its anti-aging properties...
  18. ncbi request reprint Effect of dietary cyclic nigerosylnigerose on intestinal immune functions in mice
    Keiko Hino
    Glycoscience Institute, Research Center, Hayashibara Biochemical Laboratories, Inc, Japan
    Biosci Biotechnol Biochem 70:2481-7. 2006
    ..These findings were not observed in the NOS- or IMO-fed group of mice. They suggest that CNN supplementation changes the intestinal environment of microflora and indirectly enhances the immune function in the gut...