Kanso Iwaki

Summary

Affiliation: Hayashibara Biochemical Laboratories
Country: Japan

Publications

  1. ncbi Pulmonary carcinogenesis induced by ferric nitrilotriacetate in mice and protection from it by Brazilian propolis and artepillin C
    T Kimoto
    Hayashibara Biochemical Laboratories Inc, Fujisaki Institute, Fujisaki 675 1, Okayama 702 8006, Japan
    Virchows Arch 438:259-70. 2001
  2. ncbi mAgK114 suppresses lymphocyte infiltration into epidermis in the picryl chloride-induced atopic dermatitis-like skin lesions of NC/Nga mice
    Chikako Arai
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    In Vivo 20:77-83. 2006
  3. ncbi Interferon gamma induction in human melanoma cell/allogeneic leukocyte co-cultures is enhanced by interleukin 18 but drug resistant melanoma cells are poorer inducers of IFN-gamma
    M J Micallef
    Department of Clinical Pharmacology and Therapeutics, Faculty of Medicine and Surgery, University of Malta, Msida
    Int Immunopharmacol 1:295-305. 2001
  4. ncbi Identification of the novel membrane-associated protein AgK114 on hamster keratinocytes recognized by a monoclonal antibody K114
    Tomoki Tatefuji
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    Biol Pharm Bull 27:1742-9. 2004
  5. ncbi Immuno-potentiating effects of the antler-shaped fruiting body of Ganoderma lucidum (Rokkaku-Reishi)
    Michihiro Kohguchi
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    Biosci Biotechnol Biochem 68:881-7. 2004
  6. ncbi Identification of a collagen production-promoting factor from an extract of royal jelly and its possible mechanism
    Satomi Koya-Miyata
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, Fujisaki, Okayama, Japan
    Biosci Biotechnol Biochem 68:767-73. 2004
  7. ncbi Royal Jelly prolongs the life span of C3H/HeJ mice: correlation with reduced DNA damage
    Shin Ichiro Inoue
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    Exp Gerontol 38:965-9. 2003
  8. ncbi Analysis of the antiviral activities of natural IFN-alpha preparations and their subtype compositions
    Y Yanai
    Fujisaka Institute, Hayashibara Biochemical Laboratories, Inc, Okayama 702 8006, Japan
    J Interferon Cytokine Res 21:835-41. 2001
  9. ncbi Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose
    Toshio Ariyasu
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    In Vitro Cell Dev Biol Anim 39:80-8. 2003
  10. ncbi Prevention of azoxymethane-induced intestinal tumors by a crude ethyl acetate-extract and tryptanthrin extracted from Polygonum tinctorium Lour
    S Koya-Miyata
    Hayashibara Biochemical Laboratories Inc, Fujisaki Institute, Okayama, Japan
    Anticancer Res 21:3295-300. 2001

Collaborators

Detail Information

Publications69

  1. ncbi Pulmonary carcinogenesis induced by ferric nitrilotriacetate in mice and protection from it by Brazilian propolis and artepillin C
    T Kimoto
    Hayashibara Biochemical Laboratories Inc, Fujisaki Institute, Fujisaki 675 1, Okayama 702 8006, Japan
    Virchows Arch 438:259-70. 2001
    ..Propolis and artepillin C therefore appear to inhibit lipid peroxidation and the development of pulmonary cancers...
  2. ncbi mAgK114 suppresses lymphocyte infiltration into epidermis in the picryl chloride-induced atopic dermatitis-like skin lesions of NC/Nga mice
    Chikako Arai
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    In Vivo 20:77-83. 2006
    ..This suggests that mAgK114 has an important effect on skin wound repairing...
  3. ncbi Interferon gamma induction in human melanoma cell/allogeneic leukocyte co-cultures is enhanced by interleukin 18 but drug resistant melanoma cells are poorer inducers of IFN-gamma
    M J Micallef
    Department of Clinical Pharmacology and Therapeutics, Faculty of Medicine and Surgery, University of Malta, Msida
    Int Immunopharmacol 1:295-305. 2001
    ....
  4. ncbi Identification of the novel membrane-associated protein AgK114 on hamster keratinocytes recognized by a monoclonal antibody K114
    Tomoki Tatefuji
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    Biol Pharm Bull 27:1742-9. 2004
    ..In addition, AgK114 was also induced in elongating edge epidermal keratinocytes during tissue regeneration after an excised wounding. These results suggest that AgK114 is involved in the recovering process from injury...
  5. ncbi Immuno-potentiating effects of the antler-shaped fruiting body of Ganoderma lucidum (Rokkaku-Reishi)
    Michihiro Kohguchi
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    Biosci Biotechnol Biochem 68:881-7. 2004
    ..Our results suggest that the oral administration of RR resulted in Th1-associated immuno-potentiating activities in vivo...
  6. ncbi Identification of a collagen production-promoting factor from an extract of royal jelly and its possible mechanism
    Satomi Koya-Miyata
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, Fujisaki, Okayama, Japan
    Biosci Biotechnol Biochem 68:767-73. 2004
    ..These result suggest that HBRJ-CPF identified as 10H2DA promoted the collagen production of AA-2G-treated fibroblasts by inducing TGF-beta 1 production...
  7. ncbi Royal Jelly prolongs the life span of C3H/HeJ mice: correlation with reduced DNA damage
    Shin Ichiro Inoue
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    Exp Gerontol 38:965-9. 2003
    ..However, RJ did not extend the total life span. These results indicated that dietary RJ increased the average life span of C3H/HeJ mice, possibly through the mechanism of reduced oxidative damage...
  8. ncbi Analysis of the antiviral activities of natural IFN-alpha preparations and their subtype compositions
    Y Yanai
    Fujisaka Institute, Hayashibara Biochemical Laboratories, Inc, Okayama 702 8006, Japan
    J Interferon Cytokine Res 21:835-41. 2001
    ..Our results suggest that optimal preparations of synergistically acting subtypes may provide more therapeutic benefit to patients...
  9. ncbi Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose
    Toshio Ariyasu
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    In Vitro Cell Dev Biol Anim 39:80-8. 2003
    ..Our system is a valuable tool not only for understanding the relationship between sweeteners and their receptors but also for exploring the diversities of their receptors, resulting in the design of new high-potency sweeteners...
  10. ncbi Prevention of azoxymethane-induced intestinal tumors by a crude ethyl acetate-extract and tryptanthrin extracted from Polygonum tinctorium Lour
    S Koya-Miyata
    Hayashibara Biochemical Laboratories Inc, Fujisaki Institute, Okayama, Japan
    Anticancer Res 21:3295-300. 2001
    ..These results show that the AcOEt-extract of Indigo and tryptanthrin have cancer chemopreventive activity...
  11. ncbi The natural plant product tryptanthrin ameliorates dextran sodium sulfate-induced colitis in mice
    Mark J Micallef
    Fujisaki Institute, Hayashibara Biochemical Laboratories Inc, Okayama, Japan
    Int Immunopharmacol 2:565-78. 2002
    ..Remarkably, whereas 90% of the vehicle-treated mice died from wasting disease, all the TRYP-treated mice survived, suggesting that TRYP may have a therapeutic effect on colitis...
  12. ncbi Trehalose augments osteoprotegerin production in the FHs74Int human intestinal epithelial cell line
    Toshio Ariyasu
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    In Vitro Cell Dev Biol Anim 38:30-4. 2002
    ..Thus, these results suggest that trehalose promotes the production of OPG by intestinal epithelial cells, which then acts on bone marrow cells, resulting in the suppression of osteoclastogenesis...
  13. ncbi Promoting effect of kaempferol on the differentiation and mineralization of murine pre-osteoblastic cell line MC3T3-E1
    Masaki Miyake
    Fujisaki Institute, Hayashibara Biochemical Laboratories Inc 675 Fujisaki, Okayama 702 8006, Japan
    Biosci Biotechnol Biochem 67:1199-205. 2003
    ..These results suggest that kaempferol may be a promising agent for the prevention or treatment of bone loss, especially when combined with ipriflavone...
  14. ncbi The anti-tumor activities of interferon (IFN)-alpha in chronic myelogenous leukaemia (CML)-derived cell lines depends on the IFN-alpha subtypes
    Yoshiaki Yanai
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    Cancer Lett 185:173-9. 2002
    ..IFN-alpha8 was the most potent at upregulating immunomodulatory molecule expression while IFN-alpha1 was least potent. These data indicate in vitro distinctions between IFN-alpha subtypes that should be appreciated more in the clinic...
  15. ncbi Lumin, a cyanine dye, enhances interleukin 12-dependent interferon gamma production by lipopolysaccharide-stimulated mouse splenocytes
    Toshio Kunikata
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    Biol Pharm Bull 25:1018-21. 2002
    ....
  16. ncbi The effect of AgK114 on wound healing
    Tomoki Tatefuji
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, Fujisaki, Okayama, Japan
    Biol Pharm Bull 29:896-902. 2006
    ..These results suggest that the AgK114 participates in the wound response during the healing process, and promotes wound repair...
  17. ncbi Apoptosis of human leukemia cells induced by Artepillin C, an active ingredient of Brazilian propolis
    T Kimoto
    Fujisaki Institute, Hayashibara Biochemical Laboratories Inc, Fujisaki 675 1, Okayama 702 8006, Japan
    Anticancer Res 21:221-8. 2001
    ..These results suggested that Artepillin C, an active ingredient of Brazilian propolis, has anti-leukemic effects with limited inhibitory effects on normal lymphocytes...
  18. doi Trehalose prevents adipocyte hypertrophy and mitigates insulin resistance
    Chikako Arai
    Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    Nutr Res 30:840-8. 2010
    ..These findings further suggest that trehalose is a functional saccharide that mitigates insulin resistance...
  19. ncbi Inhibitory effects of 2-amino-3H-phenoxazin-3-one on the melanogenesis of murine B16 melanoma cell line
    Masaki Miyake
    Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    Biosci Biotechnol Biochem 74:753-8. 2010
    ..These results suggest that APO is a promising depigmenting agent with both therapeutic and cosmetic value in preventing melanogenesis...
  20. ncbi Suppressive effects of a cyanine dye against herpes simplex virus (HSV)-1 infection
    Chie Ushio
    Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    Biomed Res 30:365-8. 2009
    ..These results suggest that lumin exerts an antiviral action against HSV-1 with the independent pathways of IFN-alpha and also it would become a therapeutically effective drug in clinical practice...
  21. ncbi Propolis prevents diet-induced hyperlipidemia and mitigates weight gain in diet-induced obesity in mice
    Satomi Koya-Miyata
    Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, Naka ku, Okayama 702 8006, Japan
    Biol Pharm Bull 32:2022-8. 2009
    ..These results suggest that propolis extract prevented and mitigated high-fat diet-induced hyperlipidemia by down-regulating the expression of genes associated with lipid metabolism...
  22. ncbi Cloning and expression of interleukin-18 binding protein
    Y Aizawa
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Okayama, Japan
    FEBS Lett 445:338-42. 1999
    ..In addition, they inhibited interleukine-18 dependent IFN-gamma production from KG-1 cells effectively. These results suggest that the interleukin-18 binding protein may possess interleukine-18 antagonist activity...
  23. ncbi Lactosucrose inhibits body fat accumulation in rats by decreasing intestinal lipid absorption
    Akiko Mizote
    Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    Biosci Biotechnol Biochem 73:582-7. 2009
    ..Thus, LS may reduce adipose tissue accumulation by inhibiting intestinal lipid absorption via a direct interaction with TG...
  24. ncbi Intracellular production of interleukin-18 in human epithelial-like cell lines is enhanced by hyperosmotic stress in vitro
    M Takeuchi
    Fujisaki Institute, Hayashibara Biochemical Laboratories, 675 1, Fujisaki, Okayama 702 8006, Japan
    Cell Tissue Res 297:467-73. 1999
    ..These results show for the first time that hyperosmotic stress is a stimulator of interleukin-18 production in epithelial-like cells...
  25. ncbi In vivo therapeutic effects of IFN-gamma on human myelogenous leukemia in a severe combined immunodeficiency mouse model
    C Arai
    Nagano Laboratory, Hayashibara Biochemical Labs, Inc, Okayama, Japan
    In Vivo 13:445-51. 1999
    ..In this study, we have re-evaluated the anti-leukemic effects of natural human IFN-gamma (nHuIFN-gamma) using an established human myelogenous leukemia model in SCID mice...
  26. ncbi Regulation of Candida albicans morphogenesis by tumor necrosis factor-alpha and potential for treatment of oral candidiasis
    Hitomi Ohta
    Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, Okayama, Japan
    In Vivo 21:25-32. 2007
    ..albicans). However, it is unclear whether exogenous TNF-alpha has a beneficial or detrimental effect against Candida...
  27. ncbi Tryptanthrin inhibits nitric oxide and prostaglandin E(2) synthesis by murine macrophages
    T Ishihara
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, 702 8006, Okayama, Japan
    Eur J Pharmacol 407:197-204. 2000
    ..5 microM. Thus, tryptanthrin has the dual functions of inhibiting both NO and prostaglandin E(2) production by activated macrophages, suggesting that tryptanthrin exhibits anti-inflammatory properties...
  28. ncbi Indirubin inhibits inflammatory reactions in delayed-type hypersensitivity
    T Kunikata
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, 675 1, Okayama 702 8006, Fujisaki, Japan
    Eur J Pharmacol 410:93-100. 2000
    ..The amount of interferon-gamma in the culture supernatants of elicited mouse lymphocytes was inhibited by indirubin treatment. These results suggest that indirubin is a compound with anti-inflammatory effects...
  29. ncbi Enhanced antioxidant defense due to extracellular catalase activity in Syrian hamster during arousal from hibernation
    Hitomi Ohta
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc 675 1 Fujisaki, Okayama 702 8006, Japan
    Comp Biochem Physiol C Toxicol Pharmacol 143:484-91. 2006
    ..These results suggest that extracellular catalase is effective for protecting hibernators from oxidative stress evoked by arousal from hibernation...
  30. ncbi Effect of AgK114 on picryl chloride-induced chronic contact hypersensitivity responses
    Chikako Arai
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    In Vivo 20:347-51. 2006
    ..In this study, the effects of AgK114 on the systemic immune response were examined in contact hypersensitivity (CHS) model mice...
  31. ncbi Oral administration of royal jelly inhibits the development of atopic dermatitis-like skin lesions in NC/Nga mice
    Yoshifumi Taniguchi
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, Fujisaki 675 1, Okayama 702 8006, Japan
    Int Immunopharmacol 3:1313-24. 2003
    ..Thus, our results suggest that RJ suppresses the development of AD-like skin lesions in PiCl-treated NC/Nga mice, possibly by a combination of down-regulating TNP-specific IFN-gamma production and up-regulating iNOS expression...
  32. ncbi Major royal jelly protein 3 modulates immune responses in vitro and in vivo
    Iwao Okamoto
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, 702 8006 Okayama, Japan
    Life Sci 73:2029-45. 2003
    ..Furthermore, considering the intriguing immunomodulatory effects of MRJP3, it may be of clinical significance to design MRJP3-derived antiallergic peptides by identifying the associated polypeptide regions...
  33. ncbi Anti-inflammatory and immunomodulatory properties of 2-amino-3H-phenoxazin-3-one
    Keizo Kohno
    Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    Biol Pharm Bull 31:1938-45. 2008
    ....
  34. ncbi Royal jelly inhibits the production of proinflammatory cytokines by activated macrophages
    Keizo Kohno
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    Biosci Biotechnol Biochem 68:138-45. 2004
    ..Thus, our results suggest that RJ has anti-inflammatory actions through inhibiting proinflammatory cytokine production by activated macrophages...
  35. ncbi Tryptanthrin inhibits interferon-gamma production by Peyer's patch lymphocytes derived from mice that had been orally administered staphylococcal enterotoxin
    Yasuhiko Takei
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    Biol Pharm Bull 26:365-7. 2003
    ..These results suggest that tryptanthrin may be effective in the treatment of disorders of the intestines, such as food poisoning, that are associated with activated lymphocytes...
  36. ncbi Effects of dietary lactosucrose (4G-beta-D-galactosylsucrose) on the IgE response in mice
    Yoshifumi Taniguchi
    Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc Okayama 702 8006, Japan
    Biosci Biotechnol Biochem 71:2766-73. 2007
    ..Our findings indicate the further possibility that dietary LS supplementation can be used to prevent IgE-mediated allergic diseases...
  37. doi Tryptanthrin inhibits Th2 development, and IgE-mediated degranulation and IL-4 production by rat basophilic leukemia RBL-2H3 cells
    Kanso Iwaki
    Drugs, Cosmetics and Chemicals Development Center, Hayashibara Biochemical Laboratories, Inc, Japan
    J Ethnopharmacol 134:450-9. 2011
    ..Tryptanthrin is a compound isolated from Polygonum tinctorium, which is a known folk medicine with various biological activities...
  38. ncbi The flavonoid Kaempferol suppresses the graft-versus-host reaction by inhibiting type 1 cytokine production and CD8+ T cell engraftment
    Iwao Okamoto
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Incorporated, Japan
    Clin Immunol 103:132-44. 2002
    ..Thus, our study indicates that Kaempferol has the capacity to modulate the Th1/Th2 balance and could be useful for the treatment of cell-mediated immune diseases, such as acute GVHD...
  39. ncbi Inhibition of chlamydia trachomatis growth by human interferon-alpha: mechanisms and synergistic effect with interferon-gamma and tumor necrosis factor-alpha
    Tatsuya Ishihara
    Fujisaki Institute, Hayashibara Biochemical Laboratories Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    Biomed Res 26:179-85. 2005
    ....
  40. ncbi Characterization of royal jelly proteins in both Africanized and European honeybees (Apis mellifera) by two-dimensional gel electrophoresis
    Osamu Sano
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    J Agric Food Chem 52:15-20. 2004
    ..Thus, the results suggest that two-dimensional gel electrophoresis provides a suitable method for the qualitative analysis of the proteins contained in RJ derived from different honeybee species...
  41. ncbi Purification, identification, characterization, and cDNA cloning of a high molecular weight extracellular superoxide dismutase of hamster that transiently increases in plasma during arousal from hibernation
    Kenji Akita
    Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    Comp Biochem Physiol A Mol Integr Physiol 146:223-32. 2007
    ..Furthermore, results obtained here also propose the involvement of EC-SOD in the antioxidative defense of hibernating hamsters...
  42. ncbi Suppressed Nna1 gene expression in the brain of ataxic Syrian hamsters
    Kenji Akita
    Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Fujisaki, Okayama, Japan
    J Neurogenet 21:19-29. 2007
    ..These results strongly suggest that pcd-type mutation is involved in the ataxic phenotype of mutant hamsters...
  43. ncbi Up-regulation of an extracellular superoxide dismutase-like activity in hibernating hamsters subjected to oxidative stress in mid- to late arousal from torpor
    Iwao Okamoto
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, Okayama, Japan
    Comp Biochem Physiol C Toxicol Pharmacol 144:47-56. 2006
    ..Our results suggest that the 260-kDa extracellular SOD-like activity plays a role in the tolerance for the oxidative stress during arousal from torpor...
  44. doi The ataxic Syrian hamster: an animal model homologous to the pcd mutant mouse?
    Kenji Akita
    Biomedical Institute, Research Center, Hayashibara Biochemical Laboratories, Inc, Okayama 702 8006, Japan
    Cerebellum 8:202-10. 2009
    ..A phenotypic comparison of ataxic hamsters with the pcd mutant mice suggests that the influence of the causal allele in ataxic hamsters is considerably milder than most of the alleles found in the mutant mice...
  45. ncbi IL-18 prevents the development of chronic graft-versus-host disease in mice
    I Okamoto
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    J Immunol 164:6067-74. 2000
    ..Thus, our results suggest that IL-18 has beneficial effects in the prevention and treatment of chronic GVHD...
  46. ncbi A novel phenomenon predicting the entry into a state of hibernation in Syrian hamsters (Mesocricetus auratus)
    Shigeyuki Arai
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    J Vet Med Sci 67:215-7. 2005
    ..Although the mechanism by which this phenomenon takes place is not clear, it is a sign from the body, which is useful for indicating if a hamster will enter hibernation shortly...
  47. ncbi Antitumor activity of interleukin-18 against the murine T-cell leukemia/lymphoma EL-4 in syngeneic mice
    Sachiko Akamatsu
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    J Immunother 25:S28-34. 2002
    ..These results suggest that antitumor efficacy of IL-18 is mediated primarily by NK cells, but that T cells are also required for the complete antitumor efficacy of IL-18...
  48. ncbi Cell differentiation and apoptosis of monocytic and promyelocytic leukemia cells (U-937 and HL-60) by tryptanthrin, an active ingredient of Polygonum tinctorium Lour
    T Kimoto
    Hayashibara Biochemical Laboratories Inc, Fujisaki Institute, Okayama, Japan
    Pathol Int 51:315-25. 2001
    ..These results show that low concentrations of tryptanthrin can induce differentiation of leukemia cells but higher concentrations will kill leukemia cells through apoptosis, possibly through a caspase-3/Fas antigen pathway...
  49. ncbi Antibacterial action of tryptanthrin and kaempferol, isolated from the indigo plant (Polygonum tinctorium Lour.), against Helicobacter pylori-infected Mongolian gerbils
    M Kataoka
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Okayama, Japan
    J Gastroenterol 36:5-9. 2001
    ..We concluded that tryptanthrin and kaempferol were effective against H. pylori in vivo...
  50. ncbi Preventive effect of Coriandrum sativum (Chinese parsley) on localized lead deposition in ICR mice
    M Aga
    Hayashibara Biochemical Laboratories, Inc, Fujisaki Institute, 675-1 Fujisaki, Okayama 702-8006, Japan
    J Ethnopharmacol 77:203-8. 2001
    ..These results suggest that Chinese parsley has suppressive activity on lead deposition, probably resulting from the chelation of lead by some substances contained in Chinese parsley...
  51. ncbi Age-dependent changes in phenotypes and candidate gene analysis in a polygenic animal model of Type II diabetes mellitus; NSY mouse
    H Ueda
    Department of Geriatric Medicine, Osaka University Medical School, Suita, Japan
    Diabetologia 43:932-8. 2000
    ..The aim of this study was to clarify the influence of age on the pathogenesis of diabetes and to analyse a candidate gene for Type II diabetes in this strain...
  52. ncbi Tissue-specific and glucose-dependent expression of receptor genes for glucagon and glucagon-like peptide-1 (GLP-1)
    E Yamato
    Department of Geriatric Medicine, Osaka University Medical School, Japan
    Horm Metab Res 29:56-9. 1997
    ..These results suggest that glucagon and GLP-1 receptor genes are expressed in pancreatic beta cells and their expression is upregulated by glucose...
  53. ncbi Purification and characterization of the human interleukin-18 receptor
    K Torigoe
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, 675 1 Fujisaki, Okayama, 702 Japan
    J Biol Chem 272:25737-42. 1997
    ..When expressed in COS-1 cells, the cDNA of IL-1Rrp conferred IL-18 binding properties on the cells and the capacity for signal transduction. From these results, we conclude that a functional IL-18 receptor component is IL-1Rrp...
  54. ncbi Augmentation of in vitro interleukin 10 production after in vivo administration of interleukin 18 is activated macrophage-dependent and is probably not involved in the antitumor effects of interleukin 18
    M J Micallef
    Fujisaki Institute, Hayashibara Biochemical Laboratories Inc, Okayama, Japan
    Anticancer Res 18:4267-74. 1998
    ..In vivo experiments using anti-IL-10 antibody indicated that IL-10 may not be directly involved in the antitumor effects of IL-18...
  55. ncbi Sequence analysis of candidate genes for common susceptibility to type 1 and type 2 diabetes in mice
    K Yamada
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Japan
    Endocr J 48:241-7. 2001
    ..The coding sequence of Txn was identical in the three strains. These data suggest that neither of the two genes is a common susceptiblity gene between type 1 and type 2 diabetes in mice...
  56. pmc Identification of a new susceptibility locus for insulin-dependent diabetes mellitus by ancestral haplotype congenic mapping
    H Ikegami
    Department of Geriatric Medicine, Osaka University Medical School, Japan
    J Clin Invest 96:1936-42. 1995
    ..Our results not only map a new MHC-linked diabetogenic gene(s) but also suggest a new way to fine map disease susceptibility genes within a region where strong linkage disequilibrium exists...
  57. ncbi beta-cell neogenesis induced by adenovirus-mediated gene delivery of transcription factor pdx-1 into mouse pancreas
    H Taniguchi
    Division of Stem Cell Regulation Research, Osaka University Graduate School of Medicine, Osaka, Japan
    Gene Ther 10:15-23. 2003
    ..Thus, beta-cell neogenesis induced by adenovirus-mediated expression of pdx-1 provides a novel strategy for gene therapy for a cure for diabetes mellitus...
  58. ncbi Mapping and promoter sequencing of HNF-1beta gene in diabetes-prone and -resistant mice
    H Ueda
    Department of Geriatric Medicine, Osaka University Medical School, 2 2 Yamadaoka, Suita, 565 0871, Osaka, Japan
    Diabetes Res Clin Pract 53:67-71. 2001
    ..3 cM)-Tcf2-(0.5 cM)-D11MIT195. A variant with insertion of C between -205 and -204 in the promoter region of Tcf2 was identified in NSY mice, but not NOD and C3H/He mice...
  59. ncbi Characterization of the antitumor activities of IFN-alpha8 on renal cell carcinoma cells in vitro
    Y Yanai
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, Okayama 702-8006, Japan
    J Interferon Cytokine Res 21:1129-36. 2001
    ..These data indicate that subtypes of IFN-alpha have disparate antitumor effects in vitro, and in vitro distinctions among the IFN-alpha subtypes should be appreciated more in clinical application...
  60. ncbi Allelic variation in class I K gene as candidate for a second component of MHC-linked susceptibility to type 1 diabetes in non-obese diabetic mice
    K Inoue
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Diabetologia 47:739-47. 2004
    ..In the non-obese diabetic (NOD) mouse, a second component (Idd16) has been mapped to a region adjacent to, but distinct from Idd1 in the class II region. In this study, we investigated the class I K gene as a candidate gene for Idd16...
  61. ncbi Insulin secretion to glucose as well as nonglucose stimuli is impaired in spontaneously diabetic Nagoya-Shibata-Yasuda mice
    Y Hamada
    Department of Geriatric Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan
    Metabolism 50:1282-5. 2001
    ..NSY mice, therefore, could be a novel animal model of type 2 diabetes with a defect in insulin secretion at a different site from that in previously known animal models...
  62. ncbi MHC-linked diabetogenic gene of the NOD mouse: molecular mapping of the 3' boundary of the diabetogenic region
    H Ikegami
    Department of Geriatric Medicine, Osaka University Medical School, Japan
    Biochem Biophys Res Commun 192:677-82. 1993
    ....
  63. ncbi Development of autoimmune diabetes in glutamic acid decarboxylase 65 (GAD65) knockout NOD mice
    T Yamamoto
    Division of Stem Cell Regulation Research, G6, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Diabetologia 47:221-4. 2004
    ..To investigate the role of glutamic acid decarboxylase 65 (GAD65) in the development of the Type 1 diabetes of non-obese diabetic (NOD) mice, we analysed and characterised NOD mice with targeted disruption of the GAD65 gene...
  64. ncbi Management of tight filum terminale
    M Komagata
    Department of Orthopaedic Surgery, Tokyo Medical University, Tokyo, Japan
    Minim Invasive Neurosurg 47:49-53. 2004
    ..The present study was designed to investigate surgical results concerning neurological perspectives and diagnostic methods for TFT...
  65. ncbi Genetic analysis of late-onset type 2 diabetes in a mouse model of human complex trait
    H Ueda
    Department of Geriatric Medicine, Osaka University Medical School, Suita, Japan
    Diabetes 48:1168-74. 1999
    ..The mouse model we used will serve as a useful model for future studies on the etiology of late-onset polygenic type 2 diabetes in humans...
  66. ncbi The Pro12 -->Ala substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes
    H Mori
    Second Department of Internal Medicine, Kobe University School of Medicine, Japan
    Diabetes 50:891-4. 2001
    ....
  67. ncbi Fatty liver and obesity: phenotypically correlated but genetically distinct traits in a mouse model of type 2 diabetes
    M Itoi-Babaya
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Diabetologia 50:1641-8. 2007
    ..Our aim was to investigate the association of fatty liver with obesity and other diabetes-related phenotypes and to define the genetic control of obesity and fatty liver...
  68. ncbi Polymorphism in gene for islet autoantigen, IA-2, and type 1 diabetes in Japanese subjects
    M Nishino
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Hum Immunol 62:518-22. 2001
    ..In conclusion, IA-2 gene polymorphism is not associated with either susceptibility to, or heterogeneity in type 1 diabetes in Japanese subjects...
  69. ncbi Major quantitative trait locus on chromosome 2 for glucose tolerance in diabetic SMXA-5 mouse established from non-diabetic SM/J and A/J strains
    M Kobayashi
    Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan
    Diabetologia 49:486-95. 2006
    ..These diabetic traits are worsened by feeding a high-fat diet. The aim of this study was to dissect the diabetogenic loci in the A/J regions of the SMXA-5 genome that contribute to diabetes-related traits...