Akira Harashima

Summary

Affiliation: Hayashibara Biochemical Laboratories
Country: Japan

Publications

  1. ncbi Transforming growth factor-beta(1) augments granulocyte-macrophage colony-stimulating factor-induced proliferation of umbilical cord blood CD34(+) cells with an associated tyrosine phosphorylation of STAT5
    Motoyuki Suzuki
    Fujisaki Cell Center, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    Exp Hematol 30:1132-8. 2002
  2. ncbi A novel ALL-L3 cell line, BALM-25, expressing both immunoglobulin light chains
    Yoshinobu Matsuo
    Fujisaki Cell Center, Hayashibara Biochemical Labs Inc, Okayama 702 8006, Japan
    Leuk Lymphoma 45:575-81. 2004
  3. ncbi Transcription factor expression in B-cell precursor-leukemia cell lines: preferential expression of T-bet
    Akira Harashima
    Fujisaki Cell Center, Hayashibara Biochemical Labs Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    Leuk Res 29:841-8. 2005
  4. ncbi A thymus-specific noncoding RNA, Thy-ncR1, is a cytoplasmic riboregulator of MFAP4 mRNA in immature T-cell lines
    Kazuma Aoki
    Biomedicinal Information Research Center, National Institute of Advanced Industrial Science and Technology, Koutou, Tokyo, Japan
    BMC Mol Biol 11:99. 2010
  5. ncbi Interleukin-8 and RANTES are signature cytokines made by HOZOT, a new type of regulatory T cells
    Akira Harashima
    Cell Biology Institute, Research Center, Hayashibara Biochemical Laboratories Inc, Okayama, Japan
    Mol Immunol 46:3310-9. 2009
  6. ncbi The production of IL-10 by human regulatory T cells is enhanced by IL-2 through a STAT5-responsive intronic enhancer in the IL-10 locus
    Kazue Tsuji-Takayama
    Cell Biology Institute, Research Center, Hayashibara Biochemical Laboratories, Fujisaki, Okayama, Japan
    J Immunol 181:3897-905. 2008
  7. ncbi IL-2 activation of STAT5 enhances production of IL-10 from human cytotoxic regulatory T cells, HOZOT
    Kazue Tsuji-Takayama
    Cell Biology Institute, Research Center, Hayashibara Biochemical Laboratories, Inc, Fujisaki, Okayama, Japan
    Exp Hematol 36:181-92. 2008
  8. ncbi IL-2-independent generation of FOXP3(+)CD4(+)CD8(+)CD25(+) cytotoxic regulatory T cell lines from human umbilical cord blood
    Shuji Nakamura
    Cell Biology Institute, Research Center, Hayashibara Biochemical Laboratories, Inc, Okayama, Okayama, Japan
    Exp Hematol 35:287-96. 2007
  9. ncbi CD45 tyrosine phosphatase inhibits erythroid differentiation of umbilical cord blood CD34+ cells associated with selective inactivation of Lyn
    Akira Harashima
    Fujisaki Cell Center, Hayashibara Biochemical Labs, and the Kurashiki Medical Center, Kurashiki, Okayama, Japan
    Blood 100:4440-5. 2002
  10. ncbi miR-155, a Modulator of FOXO3a Protein Expression, Is Underexpressed and Cannot Be Upregulated by Stimulation of HOZOT, a Line of Multifunctional Treg
    Mayuko Yamamoto
    Cell Biology Institute, Research Center, Hayashibara Biochemical Laboratories Inc, Okayama, Japan
    PLoS ONE 6:e16841. 2011

Collaborators

Detail Information

Publications19

  1. ncbi Transforming growth factor-beta(1) augments granulocyte-macrophage colony-stimulating factor-induced proliferation of umbilical cord blood CD34(+) cells with an associated tyrosine phosphorylation of STAT5
    Motoyuki Suzuki
    Fujisaki Cell Center, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    Exp Hematol 30:1132-8. 2002
    ..To clarify the mechanisms of the synergistic action of TGF-beta(1) and GM-CSF, we compared the activation states of STAT5 and mitogen-activated protein kinase in CD34(+) cells and in GM-CSF-dependent hematopoietic cell lines...
  2. ncbi A novel ALL-L3 cell line, BALM-25, expressing both immunoglobulin light chains
    Yoshinobu Matsuo
    Fujisaki Cell Center, Hayashibara Biochemical Labs Inc, Okayama 702 8006, Japan
    Leuk Lymphoma 45:575-81. 2004
    ..The established cell line, BALM-25, provides an unlimited supply of cell material for analyzing the unique (patho)physiology of Ig expression in general and for clarifying the pathogenesis of this type of B-cell malignancy in particular...
  3. ncbi Transcription factor expression in B-cell precursor-leukemia cell lines: preferential expression of T-bet
    Akira Harashima
    Fujisaki Cell Center, Hayashibara Biochemical Labs Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    Leuk Res 29:841-8. 2005
    ..No significant changes were observed for the other 12 TFs. The present report could provide useful information in the study of the role of TFs on normal and malignant human BCPs...
  4. ncbi A thymus-specific noncoding RNA, Thy-ncR1, is a cytoplasmic riboregulator of MFAP4 mRNA in immature T-cell lines
    Kazuma Aoki
    Biomedicinal Information Research Center, National Institute of Advanced Industrial Science and Technology, Koutou, Tokyo, Japan
    BMC Mol Biol 11:99. 2010
    ..We investigated the characteristics and function of ncRNAs that were specifically expressed in the thymus, the site of T-cell selection and maturation...
  5. ncbi Interleukin-8 and RANTES are signature cytokines made by HOZOT, a new type of regulatory T cells
    Akira Harashima
    Cell Biology Institute, Research Center, Hayashibara Biochemical Laboratories Inc, Okayama, Japan
    Mol Immunol 46:3310-9. 2009
    ..In particular, the dual production of IL-8 and RANTES by distinct mechanisms is a hallmark of HOZOT...
  6. ncbi The production of IL-10 by human regulatory T cells is enhanced by IL-2 through a STAT5-responsive intronic enhancer in the IL-10 locus
    Kazue Tsuji-Takayama
    Cell Biology Institute, Research Center, Hayashibara Biochemical Laboratories, Fujisaki, Okayama, Japan
    J Immunol 181:3897-905. 2008
    ....
  7. ncbi IL-2 activation of STAT5 enhances production of IL-10 from human cytotoxic regulatory T cells, HOZOT
    Kazue Tsuji-Takayama
    Cell Biology Institute, Research Center, Hayashibara Biochemical Laboratories, Inc, Fujisaki, Okayama, Japan
    Exp Hematol 36:181-92. 2008
    ..In this study, we examined the mechanisms of high IL-10 production by HOZOT, focusing on Janus activating kinase (JAK)/signal transducers and activators of transcription (STAT) signaling pathway...
  8. ncbi IL-2-independent generation of FOXP3(+)CD4(+)CD8(+)CD25(+) cytotoxic regulatory T cell lines from human umbilical cord blood
    Shuji Nakamura
    Cell Biology Institute, Research Center, Hayashibara Biochemical Laboratories, Inc, Okayama, Okayama, Japan
    Exp Hematol 35:287-96. 2007
    ..Here we show the establishment of novel Treg cell lines possessing unique characteristics...
  9. ncbi CD45 tyrosine phosphatase inhibits erythroid differentiation of umbilical cord blood CD34+ cells associated with selective inactivation of Lyn
    Akira Harashima
    Fujisaki Cell Center, Hayashibara Biochemical Labs, and the Kurashiki Medical Center, Kurashiki, Okayama, Japan
    Blood 100:4440-5. 2002
    ..These findings suggest that CD45 may play a pivotal role in erythropoiesis...
  10. ncbi miR-155, a Modulator of FOXO3a Protein Expression, Is Underexpressed and Cannot Be Upregulated by Stimulation of HOZOT, a Line of Multifunctional Treg
    Mayuko Yamamoto
    Cell Biology Institute, Research Center, Hayashibara Biochemical Laboratories Inc, Okayama, Japan
    PLoS ONE 6:e16841. 2011
    ..Further studies by gain- and loss-of-function experiments supported a role for miR-155 in the regulation of FOXO3a protein expression in conventional T and HOZOT cells...
  11. ncbi Acute myeloid leukemia cell lines MOLM-17 and MOLM-18 derived from patient with advanced myelodysplastic syndromes
    Yoshinobu Matsuo
    Fujisaki Cell Center, Hayashibara Biochemical Labs Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    Leuk Res 29:701-10. 2005
    ....
  12. ncbi Induction of CD28 on the new myeloma cell line MOLP-8 with t(11;14)(q13;q32) expressing delta/lambda type immunoglobulin
    Yoshinobu Matsuo
    Fujisaki Cell Center, Hayashibara Biochemical Labs, Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    Leuk Res 28:869-77. 2004
    ..The novel MOLP-8 cell line together with the present myeloma cell lines will present useful model systems in the investigation of the biology of MM...
  13. ncbi 5-Azacytidine supports the long-term repopulating activity of cord blood CD34(+) cells
    Motoyuki Suzuki
    Fujisaki Cell Center, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    Am J Hematol 77:313-5. 2004
    ..These results indicated the involvement of DNA methylation and demethylation in controlling immaturity of hematopoietic progenitor cells and the usefulness of 5-AzaC for regulating this immaturity...
  14. ncbi Comprehensive analysis of FOXP3 mRNA expression in leukemia and transformed cell lines
    Mayuko Yamamoto
    Cell Biology Institute, Research Center, Hayashibara Biochemical Laboratories Inc, 675 1 Fujisaki, Okayama 702 8006, Japan
    Leuk Res 32:651-8. 2008
    ..The broad mRNA expression contrasts with the restricted protein expression of FOXP3 in human hematopoietic cell lines, suggesting that post-transcriptional control mechanisms may control FOXP3 protein expression...
  15. ncbi Novel mechanisms of suppressor activity exhibited by cytotoxic regulatory T cell lines, HOZOT
    Motoyuki Suzuki
    Cell Biology Institute, Research Center, Hayashibara Biochemical Laboratories, Inc, Okayama, Okayama, Japan
    Exp Hematol 37:92-100. 2009
    ..The line was established by cocultivating human umbilical cord blood cells with mouse stromal cells in the absence of exogenous cytokines. In this study, we investigated the mechanism of HOZOT's suppressor activity...
  16. ncbi Novel B-cell acute lymphoblastic leukemia sister cell lines BALM 19-23 and BALM-26 with interclonal proliferative and phenotypic heterogeneity from a patient with hypercalcemia
    Yoshinobu Matsuo
    Fujisaki Cell Center, Hayashibara Biochemical Labs Inc, Okayama, Japan
    Hum Cell 15:160-70. 2002
    ..The scientific significance of this panel of cell lines lies in the availability of a series of clonally derived but phenotypically different sister cell lines established at different phases of the disease...
  17. ncbi Transcription factor expression in cell lines derived from natural killer-cell and natural killer-like T-cell leukemia-lymphoma
    Yoshinobu Matsuo
    Fujisaki Cell Center, Hayashibara Biochemical Labs, Okayama 702 8006, Japan
    Hum Cell 17:85-92. 2004
    ..Expression analysis of TFs revealed that NK- and NKT-cell lines showed identical profiles, clearly distinct from those of the other T-ALL or BCP-ALL leukemia-derived cell lines....
  18. ncbi Establishment and characterization of new B-cell precursor leukemia cell line NALM-35
    Yoshinobu Matsuo
    Fujisaki Cell Center, Hayashibara Biochemical Labs, Inc, Okayama, Japan
    Hum Cell 15:215-23. 2002
    ..The established cell line may provide a useful model system and unprecedented opportunities for analyzing the multitude of biological aspects of normal and neoplastic B-lymphocytes and their precursors...
  19. ncbi NF-ATc2 induces apoptosis in Burkitt's lymphoma cells through signaling via the B cell antigen receptor
    Eisaku Kondo
    Department of Pathology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Eur J Immunol 33:1-11. 2003
    ..Therefore, NF-ATc2 plays a crucial role in BCR-mediated apoptosis in type IBL, providing greater insight into unique BL characteristics through BCR signaling...