Hironobu Harada

Summary

Country: Japan

Publications

  1. ncbi request reprint Introduction of wild-type p53 enhances thrombospondin-1 expression in human glioma cells
    Hironobu Harada
    Department of Neurosurgery, Ehime University School of Medicine, Shigenobu cho, Onsen gun, Ehime 791 0295, Japan
    Cancer Lett 191:109-19. 2003
  2. ncbi request reprint PTEN gene transfer suppresses the invasive potential of human malignant gliomas by regulating cell invasion-related molecules
    Koji Furukawa
    Department of Neurosurgery, Ehime University School of Medicine, Shitsukawa, Toon shi, Ehime 791 0295, Japan
    Int J Oncol 29:73-81. 2006
  3. ncbi request reprint Silencing hypoxia-inducible factor-1alpha inhibits cell migration and invasion under hypoxic environment in malignant gliomas
    Satoshi Fujiwara
    Department of Neurosurgery, Ehime University School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan
    Int J Oncol 30:793-802. 2007
  4. ncbi request reprint Downregulation of SPARC expression inhibits cell migration and invasion in malignant gliomas
    Toshimoto Seno
    Department of Neurosurgery, Ehime University School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan
    Int J Oncol 34:707-15. 2009
  5. doi request reprint Oct-3/4 promotes migration and invasion of glioblastoma cells
    Kana Kobayashi
    Department of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Toon, Ehime 791 0295, Japan
    J Cell Biochem 113:508-17. 2012
  6. doi request reprint Accuracy of diffusion tensor magnetic resonance imaging-based tractography for surgery of gliomas near the pyramidal tract: a significant correlation between subcortical electrical stimulation and postoperative tractography
    Shiro Ohue
    Department of Neurosurgery, Ehime University Graduate School of Medicine, Toon, Ehime, Japan
    Neurosurgery 70:283-93; discussion 294. 2012
  7. ncbi request reprint Introduction of p16INK4a inhibits telomerase activity through transcriptional suppression of human telomerase reverse transcriptase expression in human gliomas
    Masahiro Saito
    Department of Neurosurgery, Ehime University School of Medicine, Ehime 791 0295, Japan
    Int J Oncol 24:1213-20. 2004
  8. ncbi request reprint Midkine promoter-based conditionally replicative adenovirus for malignant glioma therapy
    Shohei Kohno
    Department of Neurosurgery, Ehime University School of Medicine, Shitsukawa, Shigenobu, Onsen gun, Ehime 791 0295, Japan
    Oncol Rep 12:73-8. 2004
  9. ncbi request reprint Downregulation of laminin alpha4 chain expression inhibits glioma invasion in vitro and in vivo
    Shigeyuki Nagato
    Department of Neurosurgery, Ehime University School of Medicine, Ehime, Japan
    Int J Cancer 117:41-50. 2005
  10. ncbi request reprint Cancer stem-like cells of glioblastoma characteristically express MMP-13 and display highly invasive activity
    Akihiro Inoue
    Department of Neurosurgery, Graduate School of Medicine, Ehime University, Toon, Ehime 791 0295, Japan
    Int J Oncol 37:1121-31. 2010

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Introduction of wild-type p53 enhances thrombospondin-1 expression in human glioma cells
    Hironobu Harada
    Department of Neurosurgery, Ehime University School of Medicine, Shigenobu cho, Onsen gun, Ehime 791 0295, Japan
    Cancer Lett 191:109-19. 2003
    ..These studies may suggest that mutation of p53 gene endows gliomas with an angiogenic phenotype by reducing thrombospondin-1 production as well as enhancing the angiogenesis inducers in the early phase of malignant progression...
  2. ncbi request reprint PTEN gene transfer suppresses the invasive potential of human malignant gliomas by regulating cell invasion-related molecules
    Koji Furukawa
    Department of Neurosurgery, Ehime University School of Medicine, Shitsukawa, Toon shi, Ehime 791 0295, Japan
    Int J Oncol 29:73-81. 2006
    ....
  3. ncbi request reprint Silencing hypoxia-inducible factor-1alpha inhibits cell migration and invasion under hypoxic environment in malignant gliomas
    Satoshi Fujiwara
    Department of Neurosurgery, Ehime University School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan
    Int J Oncol 30:793-802. 2007
    ..Targeting the HIF-1alpha molecule may be a novel therapeutic strategy for malignant gliomas...
  4. ncbi request reprint Downregulation of SPARC expression inhibits cell migration and invasion in malignant gliomas
    Toshimoto Seno
    Department of Neurosurgery, Ehime University School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan
    Int J Oncol 34:707-15. 2009
    ..These results suggest that SPARC plays an essential role in the invasive activity of human glioma cells, under hypoxic conditions. Downregulation of SPARC may be a novel anti-invasion therapeutic strategy for malignant gliomas...
  5. doi request reprint Oct-3/4 promotes migration and invasion of glioblastoma cells
    Kana Kobayashi
    Department of Molecular and Cellular Physiology, Graduate School of Medicine, Ehime University, Toon, Ehime 791 0295, Japan
    J Cell Biochem 113:508-17. 2012
    ..Therefore, Oct-3/4 might contribute to tumor promoting activity in glioblastomas...
  6. doi request reprint Accuracy of diffusion tensor magnetic resonance imaging-based tractography for surgery of gliomas near the pyramidal tract: a significant correlation between subcortical electrical stimulation and postoperative tractography
    Shiro Ohue
    Department of Neurosurgery, Ehime University Graduate School of Medicine, Toon, Ehime, Japan
    Neurosurgery 70:283-93; discussion 294. 2012
    ..Diffusion tensor (DT) imaging-based fiber tracking is a noninvasive magnetic resonance technique that can delineate the course of white matter fibers...
  7. ncbi request reprint Introduction of p16INK4a inhibits telomerase activity through transcriptional suppression of human telomerase reverse transcriptase expression in human gliomas
    Masahiro Saito
    Department of Neurosurgery, Ehime University School of Medicine, Ehime 791 0295, Japan
    Int J Oncol 24:1213-20. 2004
    ..These results were similar to those from a p53 transfection study in p53-mutated cells. These findings implicate p16 in the transcriptional regulation of telomerase activity by inhibiting the function of Sp1 in human malignant gliomas...
  8. ncbi request reprint Midkine promoter-based conditionally replicative adenovirus for malignant glioma therapy
    Shohei Kohno
    Department of Neurosurgery, Ehime University School of Medicine, Shitsukawa, Shigenobu, Onsen gun, Ehime 791 0295, Japan
    Oncol Rep 12:73-8. 2004
    ..These findings indicate that midkine promoter-based conditionally replicative adenovirus might be a promising new modality of gene therapy for malignant glioma...
  9. ncbi request reprint Downregulation of laminin alpha4 chain expression inhibits glioma invasion in vitro and in vivo
    Shigeyuki Nagato
    Department of Neurosurgery, Ehime University School of Medicine, Ehime, Japan
    Int J Cancer 117:41-50. 2005
    ..These results suggest that mainly laminin-8 is essential for the invasive activity of human glioma cells; thus, a novel therapeutic strategy could target this molecule to treat patients with malignant glioma...
  10. ncbi request reprint Cancer stem-like cells of glioblastoma characteristically express MMP-13 and display highly invasive activity
    Akihiro Inoue
    Department of Neurosurgery, Graduate School of Medicine, Ehime University, Toon, Ehime 791 0295, Japan
    Int J Oncol 37:1121-31. 2010
    ..The results suggest that the highly invasive potential of cancer stem cells depends on MMP-13 enzymatic activity, thus MMP-13 might be a potential therapeutic target for glioblastomas...
  11. ncbi request reprint Evaluation of intraoperative brain shift using an ultrasound-linked navigation system for brain tumor surgery
    Shiro Ohue
    Department of Neurosurgery, Ehime University Graduate School of Medicine, Toon, Ehime, Japan
    Neurol Med Chir (Tokyo) 50:291-300. 2010
    ..This US-linked navigation system provides information on brain shift, and improves the accuracy and utility of image-guided surgery...
  12. ncbi request reprint [Intraventricular cryptococcoma successfully treated with liposomal amphotericin B and voriconazole: a case report]
    Akihiro Inoue
    Department of Neurosurgery, Ehime University School of Medicine, Japan
    No Shinkei Geka 40:777-84. 2012
    ..Furthermore, administration of L-AMB and VRCZ may be effective in treating cases of CNS cryptococcoma...
  13. ncbi request reprint [A case of neurosurgery for meningioma in a chronic hemodialysis patient: perioperative management of chronic hemodialysis patients requiring neurosurgery]
    Akihiro Inoue
    Department of Neurosurgery, Ehime University School of Medicine
    No Shinkei Geka 41:1087-92. 2013
    ..The postoperative course was uneventful. Three weeks after surgery, the patient was discharged with no neurological deficit and resumed his daily life on maintenance hemodialysis...
  14. doi request reprint Prognosis of primary central nervous system lymphoma treated with radiotherapy alone
    Senzo Taguchi
    Department of Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791 0295, Japan
    Jpn J Radiol 30:806-10. 2012
    ..However, chemotherapy is sometimes contraindicated, and radiotherapy alone becomes the only option. We retrospectively investigated the clinical outcomes of primary CNS lymphoma patients treated with radiotherapy alone...