Katsuaki Suzuki

Summary

Affiliation: Hamamatsu University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint Genetic analyses of the brain-derived neurotrophic factor (BDNF) gene in autism
    Katsuhiko Nishimura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Biochem Biophys Res Commun 356:200-6. 2007
  2. pmc Perinatal asphyxia reduces dentate granule cells and exacerbates methamphetamine-induced hyperlocomotion in adulthood
    Tomoyasu Wakuda
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Shizuoka, Japan
    PLoS ONE 3:e3648. 2008
  3. pmc Vldlr overexpression causes hyperactivity in rats
    Keiko Iwata
    Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Mol Autism 3:11. 2012
  4. pmc Enzymes in the glutamate-glutamine cycle in the anterior cingulate cortex in postmortem brain of subjects with autism
    Chie Shimmura
    Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Mol Autism 4:6. 2013
  5. doi request reprint Metabolite alterations in the hippocampus of high-functioning adult subjects with autism
    Katsuaki Suzuki
    Osaka Hamamatsu Joint Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Int J Neuropsychopharmacol 13:529-34. 2010
  6. pmc Destruction of dopaminergic neurons in the midbrain by 6-hydroxydopamine decreases hippocampal cell proliferation in rats: reversal by fluoxetine
    Katsuaki Suzuki
    Osaka Hamamatsu Joint Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    PLoS ONE 5:e9260. 2010
  7. doi request reprint Reduced expression of apolipoprotein E receptor type 2 in peripheral blood lymphocytes from patients with major depressive disorder
    Katsuaki Suzuki
    Osaka Hamamatsu Joint Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:1007-10. 2010
  8. pmc Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders
    Katsuaki Suzuki
    Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    PLoS ONE 6:e20470. 2011
  9. doi request reprint Association studies and gene expression analyses of the DISC1-interacting molecules, pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (DBZ), with schizophrenia and with bipolar disorder
    Ayyappan Anitha
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Med Genet B Neuropsychiatr Genet 150:967-76. 2009
  10. doi request reprint Genetic analyses of roundabout (ROBO) axon guidance receptors in autism
    A Anitha
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:1019-27. 2008

Detail Information

Publications66

  1. ncbi request reprint Genetic analyses of the brain-derived neurotrophic factor (BDNF) gene in autism
    Katsuhiko Nishimura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Biochem Biophys Res Commun 356:200-6. 2007
    ..We suggest that BDNF has a possible role in the pathogenesis of autism through its neurotrophic effects on the serotonergic system...
  2. pmc Perinatal asphyxia reduces dentate granule cells and exacerbates methamphetamine-induced hyperlocomotion in adulthood
    Tomoyasu Wakuda
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Shizuoka, Japan
    PLoS ONE 3:e3648. 2008
    ..Hippocampus is one of the brain regions implicated in the late-onset dopaminergic dysfunction associated with hypoxic obstetric complications...
  3. pmc Vldlr overexpression causes hyperactivity in rats
    Keiko Iwata
    Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Mol Autism 3:11. 2012
    ..abstract:..
  4. pmc Enzymes in the glutamate-glutamine cycle in the anterior cingulate cortex in postmortem brain of subjects with autism
    Chie Shimmura
    Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Mol Autism 4:6. 2013
    ..We hypothesized that alterations in the glutamate-glutamine cycle in the ACC might play a role in the pathophysiology of autism...
  5. doi request reprint Metabolite alterations in the hippocampus of high-functioning adult subjects with autism
    Katsuaki Suzuki
    Osaka Hamamatsu Joint Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Int J Neuropsychopharmacol 13:529-34. 2010
    ..Results suggest that high-functioning adult subjects with autism have abnormal metabolite concentrations in the hippocampal formation, which may in part account for their aggression...
  6. pmc Destruction of dopaminergic neurons in the midbrain by 6-hydroxydopamine decreases hippocampal cell proliferation in rats: reversal by fluoxetine
    Katsuaki Suzuki
    Osaka Hamamatsu Joint Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    PLoS ONE 5:e9260. 2010
    ....
  7. doi request reprint Reduced expression of apolipoprotein E receptor type 2 in peripheral blood lymphocytes from patients with major depressive disorder
    Katsuaki Suzuki
    Osaka Hamamatsu Joint Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:1007-10. 2010
    ..Results from this preliminary study suggest that the expression of ApoER2 may serve as a trait marker for major depressive disorder...
  8. pmc Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders
    Katsuaki Suzuki
    Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    PLoS ONE 6:e20470. 2011
    ..The aim of the study was to explore immunological markers in peripheral plasma samples from non-medicated subjects with high-functioning ASD...
  9. doi request reprint Association studies and gene expression analyses of the DISC1-interacting molecules, pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (DBZ), with schizophrenia and with bipolar disorder
    Ayyappan Anitha
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Med Genet B Neuropsychiatr Genet 150:967-76. 2009
    ..We suggest a possible role of PCNT2 in the pathogenesis of schizophrenia. Abnormalities of PCNT2, the centrosomal protein essential for microtubule organization, may be suggested to lead to neurodevelopmental abnormalities...
  10. doi request reprint Genetic analyses of roundabout (ROBO) axon guidance receptors in autism
    A Anitha
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:1019-27. 2008
    ..Abnormalities of ROBO may lead to autism either by interfering with serotonergic system, or by disrupting neurodevelopment. To the best of our knowledge, this is the first report relating ROBO with autism...
  11. doi request reprint Genetic and expression analyses reveal elevated expression of syntaxin 1A ( STX1A) in high functioning autism
    Kazuhiko Nakamura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Int J Neuropsychopharmacol 11:1073-84. 2008
    ....
  12. ncbi request reprint Decreased expression of reelin receptor VLDLR in peripheral lymphocytes of drug-naive schizophrenic patients
    Katsuaki Suzuki
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Schizophr Res 98:148-56. 2008
    ..Our findings suggest that peripheral VLDLR mRNA levels may serve as a reliable peripheral biological marker of schizophrenia, and that the reelin-VLDLR/ApoER2 signaling pathway plays a role in the pathophysiology of schizophrenia...
  13. doi request reprint Brain serotonin and dopamine transporter bindings in adults with high-functioning autism
    Kazuhiko Nakamura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Arch Gen Psychiatry 67:59-68. 2010
    ..Although its neurobiological underpinnings are postulated to lie in abnormalities of the serotoninergic and dopaminergic systems, the details remain unknown...
  14. doi request reprint Short allele of 5-HTTLPR as a risk factor for the development of psychosis in Japanese methamphetamine abusers
    Norikazu Ezaki
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Ann N Y Acad Sci 1139:49-56. 2008
    ..Thus, we suggest a possible role for the 5-HTTLPR polymorphism in MAP psychosis...
  15. ncbi request reprint Disruption of reelin signaling attenuates methamphetamine-induced hyperlocomotion
    Hideo Matsuzaki
    Department of Anatomy and Neuroscience, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Eur J Neurosci 25:3376-84. 2007
    ..These results indicate that reelin signaling plays a pivotal role in the dopaminergic system in adult mice, especially in postsynaptic levels...
  16. ncbi request reprint Brain serotonin transporter density and aggression in abstinent methamphetamine abusers
    Yoshimoto Sekine
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Shizuoka, Japan
    Arch Gen Psychiatry 63:90-100. 2006
    ..It remains unknown whether methamphetamine damages serotonin neurons in humans...
  17. doi request reprint Downregulation of the expression of mitochondrial electron transport complex genes in autism brains
    Ayyappan Anitha
    Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Brain Pathol 23:294-302. 2013
    ..We report new candidate genes involved in abnormal brain bioenergetics in autism, supporting the hypothesis that mitochondria, critical for neurodevelopment, may play a role in autism...
  18. pmc Association of transcription factor gene LMX1B with autism
    Ismail Thanseem
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    PLoS ONE 6:e23738. 2011
    ..This is the first report on the association of LMX1B with autism, though it should be viewed with some caution considering the modest associations we report...
  19. ncbi request reprint SNP analyses of growth factor genes EGF, TGFbeta-1, and HGF reveal haplotypic association of EGF with autism
    Takao Toyoda
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu 431 3192, Japan
    Biochem Biophys Res Commun 360:715-20. 2007
    ..No significant SNP or haplotypic associations were observed for TGFbeta1 or HGF. Given the role of EGF in brain and neuronal development, we suggest a possible role of EGF in the pathogenesis of autism...
  20. ncbi request reprint An association study between catechol-O-methyl transferase gene polymorphism and methamphetamine psychotic disorder
    Atsuko Suzuki
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, and Ichihara Hospital, Chiba, Japan
    Psychiatr Genet 16:133-8. 2006
    ..This study aimed to investigate whether a functional polymorphism of the catechol-O-methyl transferase gene would be involved in the development of these psychiatric states...
  21. ncbi request reprint Gene and expression analyses reveal enhanced expression of pericentrin 2 (PCNT2) in bipolar disorder
    Ayyappan Anitha
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Biol Psychiatry 63:678-85. 2008
    ..PCNT2 has recently been identified as an interacting partner of DISC1. In this study, we investigated the role of PCNT2 in bipolar disorder, by gene expression analysis and genetic association study...
  22. ncbi request reprint Childhood-onset schizophrenia and tryptophan hydroxylase gene polymorphism
    Takahiro Sekizawa
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Shizuoka 431 3192, Japan
    Am J Med Genet B Neuropsychiatr Genet 128:24-6. 2004
    ..47, 95% CI = 0.97-2.37, P = 0.097). There was a nearly doubling of the risk for childhood-onset schizophrenia associated with the AA genotype compared to other genotype groups; OR = 1.97, 95% CI = 0.91-4.22, P = 0.058...
  23. pmc Protocadherin α (PCDHA) as a novel susceptibility gene for autism
    Ayyappan Anitha
    Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Psychiatry Neurosci 38:192-8. 2013
    ..We hypothesized that the protocadherin α gene cluster (PCDHA), which is involved in synaptic specificity and in serotonergic innervation of the brain, could be a suitable candidate gene for autism...
  24. doi request reprint An association study of monoamine oxidase A (MAOA) gene polymorphism in methamphetamine psychosis
    Kazuhiko Nakamura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Higashi ku, Hamamatsu, Shizuoka 431 3192, Japan
    Neurosci Lett 455:120-3. 2009
    ..We found no differences among females. The sample size of females with methamphetamine psychosis was too small to have significant analysis...
  25. doi request reprint Replication study of Japanese cohorts supports the role of STX1A in autism susceptibility
    Kazuhiko Nakamura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:454-8. 2011
    ..In the anterior cingulate gyrus region, STX1A expression in the autism group was found to be significantly lower than that of the control group. Thus, we suggest a possible role of STX1A in the pathogenesis of autism...
  26. doi request reprint Reduced acetylcholinesterase activity in the fusiform gyrus in adults with autism spectrum disorders
    Katsuaki Suzuki
    Research Center for Child Mental Development, Hamamatsu University School of Medicine, Japan
    Arch Gen Psychiatry 68:306-13. 2011
    ..The fusiform gyrus has been regarded as the key structure in face perception. The cholinergic system is known to regulate the function of the visual pathway, including the fusiform gyrus...
  27. doi request reprint Failure to confirm genetic association of the FXYD6 gene with schizophrenia: the Japanese population and meta-analysis
    Yasuhide Iwata
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Shizuoka, Japan
    Am J Med Genet B Neuropsychiatr Genet 153:1221-7. 2010
    ..We conclude that the FXYD6 gene does not have a major influence on susceptibility to schizophrenia across populations...
  28. ncbi request reprint Metabolite alterations in basal ganglia associated with methamphetamine-related psychiatric symptoms. A proton MRS study
    Yoshimoto Sekine
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Neuropsychopharmacology 27:453-61. 2002
    ..These findings suggest that protracted use of methamphetamine may cause metabolite alterations in the basal ganglia. Furthermore, residual psychiatric symptoms may be attributable to the metabolite alterations in the basal ganglia...
  29. doi request reprint Effects of brain amyloid deposition and reduced glucose metabolism on the default mode of brain function in normal aging
    Mitsuru Kikuchi
    Research Center for Child Mental Development, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8641, Japan
    J Neurosci 31:11193-9. 2011
    ..These findings suggest that traceable Aβ deposition, but not glucose hypometabolism, in the brain plays an important role in occurrence of neuronal discoordination in DMN along with poor working memory in healthy elderly people...
  30. ncbi request reprint Decreased serum levels of hepatocyte growth factor in male adults with high-functioning autism
    Genichi Sugihara
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:412-5. 2007
    ..In this study, we studied whether serum HGF levels are altered in subjects with high-functioning autism...
  31. doi request reprint Further evidence for the role of MET in autism susceptibility
    Ismail Thanseem
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashi ku, Hamamatsu, Shizuoka 431 3192, Japan
    Neurosci Res 68:137-41. 2010
    ..4 kb. Our results provide further evidence for a possible role of MET in the pathogenesis of ASD...
  32. ncbi request reprint Metabolite alterations in basal ganglia associated with psychiatric symptoms of abstinent toluene users: a proton MRS study
    Kiyokazu Takebayashi
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Neuropsychopharmacology 29:1019-26. 2004
    ..These findings suggest that long-term toluene use causes membrane disturbance in the basal ganglia, which is associated with residual psychiatric symptoms that persist even after long-term abstinence from toluene use...
  33. doi request reprint Serum levels of platelet-derived growth factor BB homodimers are increased in male children with autism
    Masanobu Kajizuka
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:154-8. 2010
    ..In this study, we screened serum levels of these growth factors in young male subjects with autism...
  34. ncbi request reprint Association analysis of SOD2 variants with methamphetamine psychosis in Japanese and Taiwanese populations
    Kazuhiko Nakamura
    Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Hum Genet 120:243-52. 2006
    ..014 and 0.016, respectively) and in the allelic (P value 0.004 and 0.047, respectively) frequencies. Our results suggest that Ala/Val polymorphism of the SOD2 gene could be associated with the risk of developing methamphetamine psychosis...
  35. ncbi request reprint Decreased serum levels of transforming growth factor-beta1 in patients with autism
    Kyoko Okada
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431 3192, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:187-90. 2007
    ..In this study, we studied whether serum levels of TGF-beta1 are altered in patients with autism...
  36. ncbi request reprint Decreased serum levels of epidermal growth factor in adult subjects with high-functioning autism
    Katsuaki Suzuki
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Biol Psychiatry 62:267-9. 2007
    ..In this study, we examined whether serum levels of EGF are altered in adult subjects with high-functioning autism...
  37. ncbi request reprint Increased levels of serum soluble L-selectin in unmedicated patients with schizophrenia
    Yasuhide Iwata
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Shizuoka, Japan
    Schizophr Res 89:154-60. 2007
    ..For specificity, we also investigated selectin levels in patients with major depression...
  38. doi request reprint Paternal age at birth and high-functioning autistic-spectrum disorder in offspring
    Kenji J Tsuchiya
    Osaka Hamamatsu Joint Research Center for Child Mental Development OHJRC CMD, Hamamatsu University School of Medicine, Hamamatsu 431 3192, Japan
    Br J Psychiatry 193:316-21. 2008
    ..Previous studies have reported the association between advanced paternal age at birth and the risk of autistic-spectrum disorder in offspring, including offspring with intellectual disability...
  39. pmc Alteration of plasma glutamate and glutamine levels in children with high-functioning autism
    Chie Shimmura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    PLoS ONE 6:e25340. 2011
    ....
  40. doi request reprint Decreased serum levels of adiponectin in subjects with autism
    Azusa Fujita-Shimizu
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431 3192, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:455-8. 2010
    ..This study suggests that decreased levels of serum adiponectin might be implicated in the pathophysiology of autism...
  41. doi request reprint Microglial activation in young adults with autism spectrum disorder
    Katsuaki Suzuki
    Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    JAMA Psychiatry 70:49-58. 2013
    ..However, to our knowledge, no information is available on the patterns of distribution of microglial activation in the brain in ASD...
  42. ncbi request reprint Acute and repeated administration of fluoxetine, citalopram, and paroxetine significantly alters the activity of midbrain dopamine neurons in rats: an in vivo electrophysiological study
    Yoshimoto Sekine
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Synapse 61:72-7. 2007
    ..Overall, our results indicate that the systemic administration of SSRI alters the activity of midbrain DA neurons with differential effects on VTA compared with SNC DA neurons...
  43. ncbi request reprint The effects of dentate granule cell destruction on behavioral activity and Fos protein expression induced by systemic MDMA in rats
    Mujun Won
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Shizuoka 431 3192, Japan
    Neurosci Res 46:153-60. 2003
    ....
  44. pmc Brain region-specific altered expression and association of mitochondria-related genes in autism
    Ayyappan Anitha
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, 431 3192, Japan
    Mol Autism 3:12. 2012
    ..abstract:..
  45. doi request reprint Elevated transcription factor specificity protein 1 in autistic brains alters the expression of autism candidate genes
    Ismail Thanseem
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Japan
    Biol Psychiatry 71:410-8. 2012
    ..We hypothesize that dysfunction of Sp1 could affect the expression of multiple autism candidate genes, contributing to the heterogeneity of autism...
  46. pmc Investigation of the serum levels of anterior pituitary hormones in male children with autism
    Keiko Iwata
    Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Mol Autism 2:16. 2011
    ..abstract:..
  47. pmc Decreased expression of axon-guidance receptors in the anterior cingulate cortex in autism
    Shiro Suda
    Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu 431 3192 Japan
    Mol Autism 2:14. 2011
    ..abstract:..
  48. doi request reprint Age-specific 3-month cumulative incidence of postpartum depression: the Hamamatsu Birth Cohort (HBC) Study
    Kaori Matsumoto
    Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Affect Disord 133:607-10. 2011
    ..To address this, we estimated the age-specific 3-month cumulative incidence of PPD using the Hamamatsu Birth Cohort for Mothers and Children (HBC)...
  49. pmc Serum levels of soluble platelet endothelial cell adhesion molecule-1 and vascular cell adhesion molecule-1 are decreased in subjects with autism spectrum disorder
    Yosuke Kameno
    Research Center for Child Mental Development, University of Fukui, 23 3 Matsuokashimoaizuki, Eiheiji, Fukui 910 1193, Japan
    Mol Autism 4:19. 2013
    ..However, information about school age (five to seventeen years old) ASD subjects is required to determine whether adhesion molecules are also reduced in individuals with ASD in this age range...
  50. doi request reprint Jiko-shisen-kyofu (fear of one's own glance), but not taijin-kyofusho (fear of interpersonal relations), is an east Asian culture-related specific syndrome
    Yasuhide Iwata
    Osaka Hamamatsu Joint Research Centre for Child Mental Development, Hamamatsu University School of Medicine, Handayama, Shizuoka, Japan
    Aust N Z J Psychiatry 45:148-52. 2011
    ..The aim of the study was to introduce clinical features of phobia of one's own glance to western psychiatrists...
  51. ncbi request reprint Early-onset schizophrenia and dopamine-related gene polymorphism
    Yasuhide Iwata
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Am J Med Genet B Neuropsychiatr Genet 116:23-6. 2003
    ..We did not find the relationship between the polymorphism of eight dopamine-related genes and susceptibility to EOS in a Japanese sample...
  52. ncbi request reprint Augmentation of milnacipran by risperidone in treatment for major depression
    Kunihiko Tani
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Japan
    Int J Neuropsychopharmacol 7:55-8. 2004
    ..Our experience suggests that an augmentation therapy of milnacipran plus risperidone is useful for treating patients with depression who only partially respond to various types of antidepressants and for treatment-refractory depression...
  53. pmc Irradiation in adulthood as a new model of schizophrenia
    Yasuhide Iwata
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Shizuoka, Japan
    PLoS ONE 3:e2283. 2008
    ..Epidemiological studies suggest that radiation exposure may be a potential risk factor for schizophrenia in adult humans. Here, we investigated whether adult irradiation in rats caused behavioral abnormalities relevant to schizophrenia...
  54. ncbi request reprint Evidence that variation in the peripheral benzodiazepine receptor (PBR) gene influences susceptibility to panic disorder
    Kazuhiko Nakamura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Med Genet B Neuropsychiatr Genet 141:222-6. 2006
    ..021 and 0.014, respectively). The present study provides new and important evidence that variation in the PBR gene influences susceptibility to PD...
  55. ncbi request reprint Increased serum levels of glutamate in adult patients with autism
    Atsuko Shinohe
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431 3192, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1472-7. 2006
    ..In this study, we studied whether amino acids (glutamate, glutamine, glycine, D-serine, and L-serine) related to glutamatergic neurotransmission are altered in serum of adult patients with autism...
  56. ncbi request reprint A transient lesion in splenium of the corpus callosum in a patient with childhood-onset anorexia nervosa
    Katsuhiko Nishimura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Int J Eat Disord 39:527-9. 2006
    ..This is a report of an SCC lesion in a patient with anorexia nervosa (AN)...
  57. doi request reprint In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer's disease
    Masamichi Yokokura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Eur J Nucl Med Mol Imaging 38:343-51. 2011
    ..The purpose of the present study was to clarify the in vivo relationship between Aβ accumulation and neuroinflammation in those specific brain regions in early AD...
  58. ncbi request reprint Acetaldehyde adducts in the brain of alcoholics
    Kazuhiko Nakamura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, 1 20 1 Handayama Hamamatsu shi, 431 3192 Shizuoka, Japan
    Arch Toxicol 77:591-3. 2003
    ..We demonstrated acetaldehyde adducts in the frontal cortex and the midbrain of an alcoholics. Our studies showed that an acetaldehyde adduct was produced in the brain of alcoholics...
  59. ncbi request reprint The acute and chronic administration of (+/-)-8-hydroxy-2-(Di-n-propylamino)tetralin significantly alters the activity of spontaneously active midbrain dopamine neurons in rats: an in vivo electrophysiological study
    Kazuhiko Nakamura
    Department of Psychiatry, Hamamatsu University School of Medicine 1 20 1, Handayama, Hamamatsu, 431 3192, Shizuoka, Japan
    Synapse 59:359-67. 2006
    ..01 and 0.1 mg/kg, but significantly decreased by 1 mg/kg of 8-OH-DPAT. Overall, the systemic administration of 8-OH-DPAT preferentially affects the activity of spontaneously active A10 DA neurons in rats...
  60. pmc Seasonal variations of neuromotor development by 14 months of age: Hamamatsu Birth Cohort for mothers and children (HBC Study)
    Kenji J Tsuchiya
    Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    PLoS ONE 7:e52057. 2012
    ..Neuromotor development showed cyclic seasonality during the first year of life. The effects brought about by month of birth disappeared around 1 year of age, and warmer months seemed to accelerate the neuromotor development...
  61. doi request reprint Psychosocial risk factors for postpartum depression and their relation to timing of onset: the Hamamatsu Birth Cohort (HBC) Study
    Tsuruko Mori
    Department of Child Development, United Graduate School of Child Development, Osaka University, Hamamatsu, Japan
    J Affect Disord 135:341-6. 2011
    ..To address potential difference in PPD in relation to onset of the illness, we investigated risk factors for early- and late-onset PPD using a representative birth cohort in Japan...
  62. ncbi request reprint Association of dopamine transporter loss in the orbitofrontal and dorsolateral prefrontal cortices with methamphetamine-related psychiatric symptoms
    Yoshimoto Sekine
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, 431 3192 Shizuoka, Japan
    Am J Psychiatry 160:1699-701. 2003
    ..The authors examined dopamine transporter density in the orbitofrontal cortex, dorsolateral prefrontal cortex, and amygdala in methamphetamine users and assessed the relationship of these measures to the subjects' clinical characteristics...
  63. doi request reprint Reliability and validity of autism diagnostic interview-revised, Japanese version
    Kenji J Tsuchiya
    Department of Child Development, United Graduate School of Child Development at Hamamatsu, Handayama 1 Higashiku, Hamamatsu, 431 3192, Japan
    J Autism Dev Disord 43:643-62. 2013
    ....
  64. ncbi request reprint CYP2E1 and clinical features in alcoholics
    Kazuhiko Nakamura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Neuropsychobiology 47:86-9. 2003
    ..05). In regard to liver disease or self-consciousness, this was at a trend level (p = 0.08). We have shown that the genotypes of CYP2E1 are associated with clinical features of alcoholics...
  65. ncbi request reprint Linkage disequilibrium analysis of the CHRNA7 gene and its partially duplicated region in schizophrenia
    Yasuhide Iwata
    Division of Psychological Medicine, Institute of Psychiatry, 1 Windsor Walk, Denmark Hill, London, UK
    Neurosci Res 57:194-202. 2007
    ..However, we could not exclude the possibility of a weak genetic effect due to the small sample size. Analyses of larger samples and higher-density markers, particularly around SNP9 (IVS4-1912), are still needed...
  66. ncbi request reprint Tacrolimus, a specific inhibitor of calcineurin, modifies the locomotor activity of quinpirole, but not that of SKF82958, in male rats
    Masatsuna Sakanoue
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, 1 20 1 Handayama, 431 3192 Shizuoka, Hamamatsu, Japan
    Eur J Pharmacol 438:93-7. 2002
    ..5, 1, 2 or 5 mg/kg of tacrolimus compared to vehicle-treated animals. Our results suggest that calcineurin may play a role in the alteration of locomotor activity produced by dopamine D(2)/D(3) receptors, but not dopamine D(1) receptors...