T Suda

Summary

Affiliation: Hamamatsu University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint Suplatast tosilate alters DC1/DC2 balance in peripheral blood in bronchial asthma
    Koushi Yokomura
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Handayama, Hamamatsu, Japan
    J Asthma 42:567-70. 2005
  2. pmc Idiopathic pleuroparenchymal fibroelastosis: consideration of a clinicopathological entity in a series of Japanese patients
    Hideki Kusagaya
    Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    BMC Pulm Med 12:72. 2012
  3. doi request reprint Mouse CD11bhigh lung dendritic cells have more potent capability to induce IgA than CD103+ lung dendritic cells in vitro
    Yuzo Suzuki
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama Higashi ku, Hamamatsu, Shizuoka, Japan
    Am J Respir Cell Mol Biol 46:773-80. 2012
  4. pmc Serum indoleamine 2,3-dioxygenase activity predicts prognosis of pulmonary tuberculosis
    Yuzo Suzuki
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Clin Vaccine Immunol 19:436-42. 2012
  5. doi request reprint Mouse lung CD103+ and CD11bhigh dendritic cells preferentially induce distinct CD4+ T-cell responses
    Kazuki Furuhashi
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Respir Cell Mol Biol 46:165-72. 2012
  6. ncbi request reprint Interstitial lung diseases associated with amyopathic dermatomyositis
    T Suda
    Second Division, Dept of Internal Medicine, and 2 Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Eur Respir J 28:1005-12. 2006
  7. ncbi request reprint Oncostatin M production by human dendritic cells in response to bacterial products
    Takafumi Suda
    2nd Division of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Cytokine 17:335-40. 2002
  8. doi request reprint Distinct prognosis of idiopathic nonspecific interstitial pneumonia (NSIP) fulfilling criteria for undifferentiated connective tissue disease (UCTD)
    Takafumi Suda
    2nd Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Respir Med 104:1527-34. 2010
  9. doi request reprint Acute exacerbation of interstitial pneumonia associated with collagen vascular diseases
    Takafumi Suda
    2nd Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Shizuoka 431 3192, Japan
    Respir Med 103:846-53. 2009
  10. doi request reprint Assessment of serum KL-6 as a prognostic marker in pulmonary tuberculosis patients
    S Miwa
    Department of Respiratory Medicine, Tenryu Hospital, National Hospital Organization, Hamamatsu, Japan
    Int J Tuberc Lung Dis 17:240-2. 2013

Collaborators

Detail Information

Publications79

  1. ncbi request reprint Suplatast tosilate alters DC1/DC2 balance in peripheral blood in bronchial asthma
    Koushi Yokomura
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Handayama, Hamamatsu, Japan
    J Asthma 42:567-70. 2005
    ..These data suggest that suplatast tosilate normalizes the polarized DC1/DC2 balance toward DC2 in asthma, which may also alter its Th2-dominant Th1/Th2 balance toward Th1...
  2. pmc Idiopathic pleuroparenchymal fibroelastosis: consideration of a clinicopathological entity in a series of Japanese patients
    Hideki Kusagaya
    Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    BMC Pulm Med 12:72. 2012
    ..And this study was an attempt to identify features in common between IPPFE and previously described idiopathic upper lobe fibrosis (IPUF), allowing IPPFE to be considered as a distinct entity in our Japanese series...
  3. doi request reprint Mouse CD11bhigh lung dendritic cells have more potent capability to induce IgA than CD103+ lung dendritic cells in vitro
    Yuzo Suzuki
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama Higashi ku, Hamamatsu, Shizuoka, Japan
    Am J Respir Cell Mol Biol 46:773-80. 2012
    ..These findings suggest that, of the two major LDCs, CD11b(high) LDCs more efficiently induce IgA than do CD103(+) LDCs, possibly through their potent capacity to produce IgA-inducing cytokines...
  4. pmc Serum indoleamine 2,3-dioxygenase activity predicts prognosis of pulmonary tuberculosis
    Yuzo Suzuki
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Clin Vaccine Immunol 19:436-42. 2012
    ..850), and this activity was an independent prognostic factor in multivariate analysis. These results suggest that serum IDO activity can be used as a novel prognostic marker in PTB...
  5. doi request reprint Mouse lung CD103+ and CD11bhigh dendritic cells preferentially induce distinct CD4+ T-cell responses
    Kazuki Furuhashi
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Respir Cell Mol Biol 46:165-72. 2012
    ..These data suggest that mouse CD103(+) LDCs predominantly elicit Th1 and Th17 responses, whereas CD11b(high) LDCs primarily provoke a Th2 response under the steady state...
  6. ncbi request reprint Interstitial lung diseases associated with amyopathic dermatomyositis
    T Suda
    Second Division, Dept of Internal Medicine, and 2 Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Eur Respir J 28:1005-12. 2006
    ..In conclusion, interstitial lung disease associated with amyopathic dermatomyositis includes two different forms, the acute/subacute and chronic forms, with distinct prognoses...
  7. ncbi request reprint Oncostatin M production by human dendritic cells in response to bacterial products
    Takafumi Suda
    2nd Division of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Cytokine 17:335-40. 2002
    ....
  8. doi request reprint Distinct prognosis of idiopathic nonspecific interstitial pneumonia (NSIP) fulfilling criteria for undifferentiated connective tissue disease (UCTD)
    Takafumi Suda
    2nd Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Respir Med 104:1527-34. 2010
    ..However, this has not been confirmed in a large number of patients with idiopathic NSIP. The present study was conducted to investigate the proportion and characteristics of patients with idiopathic NSIP who meet the criteria for UCTD...
  9. doi request reprint Acute exacerbation of interstitial pneumonia associated with collagen vascular diseases
    Takafumi Suda
    2nd Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Shizuoka 431 3192, Japan
    Respir Med 103:846-53. 2009
    ..However, the incidence of AE in CVD-IP and its clinical characteristics remain to be fully determined. This study was conducted to elucidate cumulative incidence of AE in CVD-IP and its clinical features...
  10. doi request reprint Assessment of serum KL-6 as a prognostic marker in pulmonary tuberculosis patients
    S Miwa
    Department of Respiratory Medicine, Tenryu Hospital, National Hospital Organization, Hamamatsu, Japan
    Int J Tuberc Lung Dis 17:240-2. 2013
    ..These findings indicate that serum KL-6 levels do not perform adequately for use as a prognostic marker in patients with PTB...
  11. ncbi request reprint Pulmonary dendritic cell accumulation in usual interstitial pneumonia and nonspecific interstitial pneumonia
    M Karayama
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Sarcoidosis Vasc Diffuse Lung Dis 29:69-73. 2012
    ..Pulmonary dendritic cells (DCs) are key regulators of immune responses. An increased accumulation of DCs was reported in the lungs of patients with idiopathic interstitial pneumonia (IIP)...
  12. ncbi request reprint Indoleamine 2,3-dioxygenase in the pathogenesis of tuberculous pleurisy
    Y Suzuki
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan Respiratory Medicine, Tenryu Hospital, National Hospital Organization, Hamamatsu, Japan
    Int J Tuberc Lung Dis 17:1501-6. 2013
    ..However, no studies have measured and determined the clinical significance of IDO activity in pleural fluid...
  13. ncbi request reprint Decreased expression of Th2 type cytokine mRNA contributes to the lack of allergic bronchial inflammation in aged rats
    K Ide
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
    J Immunol 163:396-402. 1999
    ..These findings suggest that decreased allergic inflammation in aged animals is attributable to age-dependent impairment of Th2 generation in response to Ag...
  14. doi request reprint Drug lymphocyte stimulation test is not useful for side effects of anti-tuberculosis drugs despite its timing
    S Miwa
    Department of Respiratory Medicine, Tenryu Hospital, National Hospital Organization, Hamamatsu, Japan
    Int J Tuberc Lung Dis 16:1265-9. 2012
    ..9% sensitivity). However, it remains unclear whether the time of performance of the DLST contributed to these results...
  15. ncbi request reprint [A recurrent case of idiopathic interstitial pneumonia histologically diagnosed as nonspecific interstitial pneumonia group 1]
    Y Nakamura
    Second Department of Internal Medicine, Hamamatsu University School of Medicine, 3600 Handa-cho, Hamamatsu-shi, Shizuoka 431-3192, Japan
    Nihon Kokyuki Gakkai Zasshi 39:281-6. 2001
    ..Although it is generally accepted that patients with IIP diagnosed histologically as NSIP have a good prognosis, it should be remembered that recurrence is possible, even in patients with group 1...
  16. ncbi request reprint Anti-endothelial cell antibodies in patients with interstitial lung diseases
    Takashi Matsui
    The Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, 431 3192, Hamamatsu, Japan
    Respir Med 102:128-33. 2008
    ..However, the prevalence of AECA in patients with idiopathic interstitial pneumonias (IIPs) is not known...
  17. doi request reprint Alterations in smoking habits are associated with acute eosinophilic pneumonia
    Hiroshi Uchiyama
    Department of Internal Medicine, National Hospital Organization Tenryu Hospital, Hamamatsu, Shizuoka, Japan
    Chest 133:1174-80. 2008
    ..The present study was conducted to clarify the etiologic role of cigarette smoking in AEP, with special reference to alterations in smoking habits...
  18. doi request reprint Immunogenicity of dormancy-related antigens in individuals infected with Mycobacterium tuberculosis in Japan
    H Hozumi
    Department of Infectious Diseases, and Internal Medicine 2 Divisions of Endocrinology and Metabolism, Respiratology and Hepatology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Int J Tuberc Lung Dis 17:818-24. 2013
    ..tuberculosis-infected individuals, suggesting that DosR regulon-encoded proteins are suitable targets for vaccines to control the reactivation of dormant M. tuberculosis...
  19. ncbi request reprint Muramyl dipeptide-Lys stimulates the function of human dendritic cells
    A Todate
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    J Leukoc Biol 70:723-9. 2001
    ..These results suggested that the immunoadjuvant activity of MDP-Lys in vivo is mediated, in part, by its stimulation of DC function...
  20. ncbi request reprint [Mycoplasma pneumonia complicated by acute renal failure]
    N Enomoto
    Department of Internal Medicine, Hamamatsu Rousai Hospital, 25, Shougencho, Hamamatsu 430-0802, Japan
    Nihon Kokyuki Gakkai Zasshi 39:425-9. 2001
    ..Only one other case of mycoplasma pneumonia with hemodialysis has been reported in Japan. We report and assess the pathogenesis of mycoplasma pneumonia complicated by renal dysfunction...
  21. doi request reprint Intratracheal administration of third-generation lentivirus vector encoding MPT51 from Mycobacterium tuberculosis induces specific CD8+ T-cell responses in the lung
    Dai Hashimoto
    Department of Internal Medicine, Hamamatsu University School of Medicine, 1 20 1 Higashi ku, Handa yama, Hamamatsu 431 3192, Japan
    Vaccine 26:5095-100. 2008
    ..These findings suggest that intratracheal immunization of the third-generation lentiviral vaccines is a promising vaccination strategy against pulmonary tuberculosis...
  22. ncbi request reprint Anti-cyclic citrullinated peptide antibodies in lung diseases associated with rheumatoid arthritis
    Naoki Inui
    The Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Clin Biochem 41:1074-7. 2008
    ..In the present study, we aimed to elucidate the relationships between anti-CCP antibodies and pulmonary diseases, particularly interstitial lung disease (ILD) and bronchiolitis...
  23. ncbi request reprint alpha-Galactosylceramide, a ligand of natural killer T cells, inhibits allergic airway inflammation
    Hiroyuki Matsuda
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
    Am J Respir Cell Mol Biol 33:22-31. 2005
    ..These results indicate that alpha-GalCer prevents allergic airway inflammation possibly through IFN-gamma production by ligand-activated NKT cells, suggesting the potential therapeutic application of alpha-GalCer in asthma...
  24. doi request reprint Effect of the inoculum size on carbapenem susceptibilities of beta-lactamase-negative, ampicillin-resistant Haemophilus influenzae
    Hiroo Miyazaki
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashi ku, Hamamatsu, Shizuoka, 431 3192, Japan
    Curr Microbiol 58:18-24. 2009
    ..Thus, accurate adjustment of inoculum size, such as viable cell count, is helpful for confirming the true MICs when the isolates are interpreted as "resistant" by turbidity-based MIC determination...
  25. doi request reprint Possible therapeutic effect of direct haemoperfusion with a polymyxin B immobilized fibre column (PMX-DHP) on pulmonary oxygenation in acute exacerbations of interstitial pneumonia
    Noriyuki Enomoto
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Respirology 13:452-60. 2008
    ..However, little is known about the efficacy of PMX-DHP in acute exacerbations of other IP. This study investigated the effectiveness and safety of PMX-DHP in acute exacerbations of IP...
  26. doi request reprint Intravenous immunoglobulin therapy for refractory interstitial lung disease associated with polymyositis/dermatomyositis
    Yuzo Suzuki
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Lung 187:201-6. 2009
    ..IVIG treatment is safe and could be an effective salvage therapy for refractory ILD-PM/DM in certain cases, suggesting that further controlled trials are worthwhile...
  27. doi request reprint Anti-endothelial cell antibodies in patients with sarcoidosis
    Naoki Inui
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Chest 133:955-60. 2008
    ..In this study, we aimed to investigate the expression of AECA in patients with sarcoidosis. We also examined whether these antibodies could serve as a marker for the activity, severity, and prognosis of sarcoidosis...
  28. ncbi request reprint Use of the QuantiFERON-TB Gold test in Japanese patients with sarcoidosis
    Naoki Inui
    The Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Respir Med 102:313-5. 2008
    ..tuberculosis infection than the conventional tuberculin skin test. This study aimed to investigate the rate of positive QuantiFERON-TB Gold results in Japanese sarcoidosis patients...
  29. ncbi request reprint Effects of suplatast tosilate on cytokine profile of bronchoalveolar cells in allergic inflammation of the lung
    Kazuhiko Matsumoto
    Pharmacy Department, Hamamatsu University School of Medicine, Japan
    Respirology 7:201-7. 2002
    ..In the present study, we investigated the effects of suplatast on eosinophil infiltration and cytokine mRNA expression in bronchoalveolar lavage (BAL) fluid in a Brown Norway (BN) rat model of bronchial asthma...
  30. doi request reprint Relationship between an increased serum kynurenine/tryptophan ratio and atherosclerotic parameters in hemodialysis patients
    Akihiko Kato
    Division of Blood Purification, Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
    Hemodial Int 14:418-24. 2010
    ..03±0.15) compared with that in the first quartile (1.09±0.13) (P<0.05). It follows from these findings that the Kyn/Trp ratio increases with time on HD, and is associated with advanced atherosclerotic changes in chronic HD patients...
  31. ncbi request reprint Correlation between 25-hydroxyvitamin D3 1 alpha-hydroxylase gene expression in alveolar macrophages and the activity of sarcoidosis
    N Inui
    Department of Internal Medicine, Second Division, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Med 110:687-93. 2001
    ..82, P <0.05). CONCLUSION: There is a correlation between 1 alpha-hydroxylase gene expression in alveolar macrophages with the activity of sarcoidosis and its associated disturbances in calcium metabolism...
  32. ncbi request reprint Store depletion by caffeine/ryanodine activates capacitative Ca(2+) entry in nonexcitable A549 cells
    H H Xue
    First Department of Biochemistry, and Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Handa Cho, Hamamatsu, Shizuoka 431 3192, Japan
    J Biochem 128:329-36. 2000
    ....
  33. pmc Identification of an HLA-A*0201-restricted T-cell epitope on the MPT51 protein, a major secreted protein derived from Mycobacterium tuberculosis, by MPT51 overlapping peptide screening
    Taiki Aoshi
    Department of Infectious Diseases, Hamamatsu University School of Medicine, 1 20 1 Handa yama, Higashi ku, Hamamatsu 431 3192, Japan
    Infect Immun 76:1565-71. 2008
    ..Use of this HLA-A*0201-restricted CD8+ T-cell epitope for analysis of the role of MPT51-specific T cells in M. tuberculosis infection and for design of vaccines against tuberculosis is feasible...
  34. doi request reprint Respiratory mechanics and peripheral airway inflammation and dysfunction in asthma
    T Shirai
    Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, Japan
    Clin Exp Allergy 43:521-6. 2013
    ..The correlation between respiratory impedance and spirometry has been reported; however, the association with airway inflammation and pulmonary function, in the lung periphery in particular, is unclear...
  35. ncbi request reprint Immunization with dendritic cells retrovirally transduced with mycobacterial antigen 85A gene elicits the specific cellular immunity including cytotoxic T-lymphocyte activity specific to an epitope on antigen 85A
    Hideki Nakano
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1 20 1 Handa yama, Hamamatsu 431 3192, and Clinical Research Center, National Hospital Organization Kinki chuo Chest Medical Center, Osaka, Japan
    Vaccine 24:2110-9. 2006
    ..This eliciting cellular immunity led to protection against wasting disease due to M. tuberculosis infection and induction of moderate bacterial clearance...
  36. ncbi request reprint Differences in clinical features and prognosis of interstitial lung diseases between polymyositis and dermatomyositis
    Tomoyuki Fujisawa
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Rheumatol 32:58-64. 2005
    ..To assess the difference in clinical features and prognosis of patients with interstitial lung disease (ILD) comparing polymyositis (PM) and dermatomyositis (DM)...
  37. ncbi request reprint The incidence and clinical characteristics of bronchiolitis obliterans organizing pneumonia syndrome after radiation therapy for breast cancer
    Seiichi Miwa
    Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Sarcoidosis Vasc Diffuse Lung Dis 21:212-8. 2004
    ..However, the precise incidence of this syndrome remains to be determined. The aim of this study was to clarify the incidence and clinical characteristics of radiation-induced BOOP syndrome...
  38. doi request reprint Cumulative incidence of and predictive factors for lung cancer in IPF
    Yuichi Ozawa
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Respirology 14:723-8. 2009
    ..The present study was conducted to elucidate the cumulative incidence and risk factors for lung cancer in IPF patients by retrospective longitudinal cohort analysis...
  39. doi request reprint Mycobacterium avium complex disease: prognostic implication of high-resolution computed tomography findings
    S Kuroishi
    Second Division, Dept of Internal Medicine, Hamamatsu University School of Medicine, Handayama 1 20 1, Hamamatsu, Shizuoka, 431 3192, Japan
    Eur Respir J 32:147-52. 2008
    ..These results suggest that high-resolution computed tomography findings are good predictors of response to treatment in Mycobacterium avium complex pulmonary disease...
  40. doi request reprint Mucosal vaccine using CTL epitope-pulsed dendritic cell confers protection for intracellular pathogen
    Yuichi Ozawa
    Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Respir Cell Mol Biol 41:440-8. 2009
    ..These data suggest that mucosal vaccination with LPS-treated immunodominant CTL epitope-loaded DC is a promising strategy for generating protective CTL against respiratory infections with intracellular pathogens...
  41. doi request reprint Relationship of the asthma control test with pulmonary function and exhaled nitric oxide
    Toshihiro Shirai
    Department of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, Japan
    Ann Allergy Asthma Immunol 101:608-13. 2008
    ..The Asthma Control Test (ACT) is a short, simple, patient-based tool for identifying patients with poorly controlled asthma; however, its value in practice has yet to be demonstrated...
  42. ncbi request reprint [A case of interstitial pneumonia with anti-signal recognition particle (SRP) antibody without myopathy]
    Masato Kono
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine
    Nihon Kokyuki Gakkai Zasshi 48:92-7. 2010
    ..Later, an RNA immunoprecipitation test was positive for anti-signal recognition particle (SRP) antibody. This is a rare case of interstitial pneumonia with anti-SRP antibody without myopathy...
  43. ncbi request reprint [Clinical analysis of idiopathic nonspecific interstitial pneumonia with unfavorable outcome]
    Yutaro Nakamura
    Second Department of Internal Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu shi, Shizuoka 431 3192, Japan
    Nihon Kokyuki Gakkai Zasshi 42:293-8. 2004
    ..No significant differences in CT appearance were noted between the two cohorts. These findings provide a potential clinical marker of therapy outcome of in idiopathic NSIP...
  44. ncbi request reprint [A case of primary pulmonary MALT lymphoma as a nodular shadow on CT scan, and relapsed with diffuse micronodular shadows after surgical resection at 7 years ago]
    Shigeki Kuroishi
    Department of Respiratory Medicine, National Tenryu Hospital, 4201 2 Oro, Hamakita, Shizuoka, 434 8511, Japan
    Nihon Kokyuki Gakkai Zasshi 41:922-7. 2003
    ..It was observed that the patterns of radiological findings in primary pulmonary MALT lymphoma cases may differ between the initial state and a relapse...
  45. ncbi request reprint Alteration of balance between myeloid dendritic cells and plasmacytoid dendritic cells in peripheral blood of patients with asthma
    Hiroyuki Matsuda
    Second Division, Department of Internal Medicine, and Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Respir Crit Care Med 166:1050-4. 2002
    ..These data indicate that the patients with asthma had a polarization of the mDC:pDC balance toward pDCs, which may be involved in producing the Th2-dominant immune phenotype in asthma...
  46. ncbi request reprint [Successful treatment with cyclosporine in a case of progressive interstitial pneumonia associated with systemic sclerosis]
    Tomoyuki Fujisawa
    Department of Respiratory Medicine, Shimada Municipal Hospital, Second Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
    Nihon Kokyuki Gakkai Zasshi 41:480-5. 2003
    ..It is suggested that cyclosporine is useful for the treatment of progressive interstitial pneumonia associated with systemic sclerosis...
  47. pmc Induction of protective immunity to Listeria monocytogenes with dendritic cells retrovirally transduced with a cytotoxic T lymphocyte epitope minigene
    Yutaro Nakamura
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1 20 1 Handa yama, Hamamatsu 431 3192, Japan
    Infect Immun 71:1748-54. 2003
    ..These results provide an alternative strategy in which retrovirally transduced DCs are used to design vaccines against intracellular pathogens...
  48. ncbi request reprint Quantitative analysis of fibroblastic foci in usual interstitial pneumonia
    Noriyuki Enomoto
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Chest 130:22-9. 2006
    ..Additionally, these methods are not entirely practical because two or more pathologists are required. In this study, we tried to develop a more quantitative scoring method of FF...
  49. ncbi request reprint Impaired toll-like receptor 9 expression in alveolar macrophages with no sensitivity to CpG DNA
    Kenichiro Suzuki
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Respir Crit Care Med 171:707-13. 2005
    ..These results indicate selective loss of TLR9 expression in AMs with no sensitivity to CpG-ODN, suggesting that dendritic cells and B cells play a role in the immune response against bacterial DNA in the lung...
  50. ncbi request reprint Peripheral T-cell lymphoma with diffuse pulmonary infiltration and an increase in serum KL-6 level
    Tomoyuki Fujisawa
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Respirology 12:452-4. 2007
    ..In addition, the extensive proliferation of type II pneumocytes, which stained strongly positive for anti-KL-6 antibody suggested that the pneumocytes were the source of serum KL-6...
  51. ncbi request reprint Lung dendritic cells have a potent capability to induce production of immunoglobulin A
    Tateaki Naito
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashiku, Hamamatsu, 431 3192, Japan
    Am J Respir Cell Mol Biol 38:161-7. 2008
    ..This study suggests that LDCs are the primary APCs introducing IgA to the lung, and have a more potent IgA-inducing capacity than nonmucosal DCs...
  52. ncbi request reprint Dendritic cell involvement in pulmonary granuloma formation elicited by bacillus calmette-guérin in rats
    Tomoyoshi Tsuchiya
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Japan
    Am J Respir Crit Care Med 165:1640-6. 2002
    ....
  53. ncbi request reprint Recommended initial loading dose of teicoplanin, established by therapeutic drug monitoring, and outcome in terms of optimal trough level
    Masaki Sato
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Infect Chemother 12:185-9. 2006
    ..These findings suggest that 800 mg as an initial dose, followed by 400 mg maintenance doses over the following 2 days, makes it possible to safely attain an optimal trough level, even in the patients with HD...
  54. ncbi request reprint [Secondary pulmonary alveolar proteinosis associated with myelodysplastic syndrome]
    Koshi Yokomura
    Second Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan1 20 1 Handayama, Hamamatsu, Shizuoka, Japan, 431 3192
    Nihon Kokyuki Gakkai Zasshi 40:599-604. 2002
    ..This was a rare case of secondary pulmonary alveolar proteinosis associated with MDS successfully treated with whole-lung lavage...
  55. ncbi request reprint Fulminant community-acquired pneumonia probably caused by Acinetobacter lwoffii
    Mikio Toyoshima
    Department of Respiratory Medicine, Hamamatsu Rosai Hospital, Hamamatsu, Japan
    Respirology 15:867-8. 2010
    ..She deteriorated rapidly despite antibiotic therapy, and required ventilatory support. The patient died of multiple organ failure and intractable shock, 7 days after admission to hospital; her disease was probably caused by A. lwoffii...
  56. ncbi request reprint Clinicopathological features of chronic hypersensitivity pneumonitis
    Hiroshi Hayakawa
    Department of Internal Medicine, National Tenryu Hospital, Hamakita, Japan
    Respirology 7:359-64. 2002
    ..We present data on clinicopathological features of chronic HP obtained through a Japanese nationwide survey...
  57. doi request reprint Correlation between peripheral blood T-cell profiles and clinical and inflammatory parameters in stable COPD
    Toshihiro Shirai
    Department of Respiratory Medicine, Shizuoka General Hospital, and Hamamatsu University School of Medicine, Shizuoka, Japan
    Allergol Int 59:75-82. 2010
    ..The purpose of this study was to clarify the relationship between peripheral blood T-cell profiles and pulmonary function or inflammatory parameters...
  58. ncbi request reprint The loss of retinoic acid receptor alpha, beta and alcohol dehydrogenase3 expression in non-small cell lung cancer
    Naoki Inui
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Respirology 8:302-9. 2003
    ..Therefore we examined the retinoid-related receptor expression and the tissue distribution as well as the possible interaction between retinoid-related receptor expression and cigarette smoke...
  59. ncbi request reprint [A case of adenocarcinoma of the lung presenting symptoms of choroidal metastasis as the initial clinical manifestation]
    Hiroyuki Matsuda
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431 3192, Japan
    Nihon Kokyuki Gakkai Zasshi 42:410-4. 2004
    ..Nevertheless, she died 6 months after the initial presentation. It is important to notice ophthalmologic symptoms because lung cancer may metastasize to the choroids...
  60. doi request reprint Increased serum kynurenine/tryptophan ratio correlates with disease progression in lung cancer
    Yuzo Suzuki
    Department of Internal Medicine, Hamamatsu University School of Medicine, 1 20 1 Hanadayama Higashiku, Hamamatsu, Shizuoka 431 3125, Japan
    Lung Cancer 67:361-5. 2010
    ..Thus, the present study investigated IDO activity determined by serum Trp and Kyn concentrations in lung cancer and the correlation between the IDO activity and clinical parameters...
  61. ncbi request reprint Endosomal/lysosomal targeting of a single helper T-cell epitope of an intracellular bacterium by DNA immunisation induces a specific T-cell subset and partial protective immunity in vivo
    Hiroshi Uchiyama
    Second Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    FEMS Microbiol Lett 216:91-7. 2002
    ..These results suggest that the intracellular targeting of a Th epitope to endosomal/lysosomal compartments by DNA immunisation is useful for eliciting a specific Th subset in vivo...
  62. doi request reprint Real-time PCR is more specific than conventional PCR for induced sputum diagnosis of Pneumocystis pneumonia in immunocompromised patients without HIV infection
    Tomoyuki Fujisawa
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Respirology 14:203-9. 2009
    ..Real-time PCR (r-PCR), a method to detect the DNA quantitatively, might be helpful in distinguishing between infection and colonization. We investigated the utility of real-time PCR in the diagnosis of PCP in non-AIDS patients...
  63. ncbi request reprint Immunization with dendritic cells loaded with alpha-galactosylceramide at priming phase, but not at boosting phase, enhances cytotoxic T lymphocyte activity against infection by intracellular bacteria
    Noriyuki Enomoto
    Department of Internal Medicine, Second Division, Hamamatsu University School of Medicine, Hamamatsu, Japan
    FEMS Immunol Med Microbiol 51:350-62. 2007
    ....
  64. doi request reprint Once-daily inhaled glucocorticosteroid administration in controlled asthma patients
    Hirotsugu Hasegawa
    The Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Pulm Pharmacol Ther 21:663-7. 2008
    ..We aimed to investigate whether once-daily administration of inhaled glucocorticosteroids can control airway inflammation...
  65. ncbi request reprint A validation and potential modification of the pneumonia severity index in elderly patients with community-acquired pneumonia
    Tateaki Naito
    Department of Internal Medicine, Second Division, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Am Geriatr Soc 54:1212-9. 2006
    ..To evaluate the discriminatory power of the Pneumonia Severity Index (PSI) in elderly patients with community-acquired pneumonia (CAP) and to improve its performance...
  66. ncbi request reprint Occupational and environmental factors and idiopathic pulmonary fibrosis in Japan
    Yoshihiro Miyake
    Department of Public Health, Fukuoka University School of Medicine, Fukuoka, Japan
    Ann Occup Hyg 49:259-65. 2005
    ..23; 95% CI = 1.01-10.84). Our results appear to confirm data from previous epidemiologic studies. Metal dust exposure may be a particularly important risk factor for IPF...
  67. ncbi request reprint [Two cases of acute respiratory failure due to idiopathic interstitial pneumonia successfully treated with sivelestat sodium hydrate and steroid therapy]
    Shiro Imokawa
    Department of Respiratory Medicine, Iwata City Hospital
    Nihon Kokyuki Gakkai Zasshi 44:27-33. 2006
    ..Therefore, sivelestat sodium hydrate may be one of the treatment options for acute respiratory failure due to idiopathic interstitial pneumonia...
  68. ncbi request reprint [Case of rapid progressive interstitial pneumonia associated with primary Sjogren syndrome]
    Yoshihisa Naruse
    Department of Respiratory Medicine, Seirei Mikatahara Hospital
    Nihon Kokyuki Gakkai Zasshi 44:721-6. 2006
    ..In spite of intensive therapy, she died due to respiratory failure. We report a rare case of interstitial pneumonia with pSjS resulting in acute exacerbation...
  69. ncbi request reprint [A case of pneumonitis caused by Seisin-renshi-in, herbal medicine]
    Mikio Toyoshima
    Department of Respiratory Medicine, Hamamatsu Rosai Hospital
    Nihon Kokyuki Gakkai Zasshi 46:31-4. 2008
    ..His respiratory condition then improved and predonisolone was tapered from 30 mg. We should be aware that over-the-counter drugs could be causal agents of severe pneumonitis...
  70. ncbi request reprint Correlation between peripheral blood T-cell profiles and airway inflammation in atopic asthma
    Toshihiro Shirai
    Department of Respiratory Medicine, Shizuoka General Hospital, Japan
    J Allergy Clin Immunol 118:622-6. 2006
    ..Recent studies suggest that T(H)1/T(H)2 and T(C)1/T(C)2 cell imbalances are implicated in asthma pathogenesis. However, the relationship of T-cell profiles to airway inflammation has not been understood...
  71. ncbi request reprint [An adult case of asymptomatic congenital tracheal stenosis]
    Koushi Yokomura
    Department of Internal Medicine, Social Insurance Hamamatsu Hospital
    Nihon Kokyuki Gakkai Zasshi 43:673-7. 2005
    ..This case suggests that among healthy people there are a very few who have asymptomatic congenital tracheal stenosis...
  72. ncbi request reprint High-dose intravenous glucocorticoid therapy abrogates circulating dendritic cells
    Takafumi Suda
    J Allergy Clin Immunol 112:1237-9. 2003
  73. ncbi request reprint Case-control study of medical history and idiopathic pulmonary fibrosis in Japan
    Yoshihiro Miyake
    Department of Public Health, Fukuoka University School of Medicine, Fukuoka, Japan
    Respirology 10:504-9. 2005
    ..A relationship between a history of selected disorders and the risk of IPF was assessed in a multicentre hospital-based case-control study in Japan...
  74. ncbi request reprint [Acute respiratory failure due to pneumocystis pneumonia successfully treated with combined use of sivelestat sodium hydrate]
    Shiro Imokawa
    Department of Respiratory Medicine, Iwata City Hospital
    Nihon Kokyuki Gakkai Zasshi 46:461-5. 2008
    ..Sivelestat sodium hydrate is an anti-neutrophil elastase inhibitor and may be one of the treatment options for acute respiratory failure due to pneumocystis pneumonia in AIDS patients...
  75. ncbi request reprint [A case of diffuse alveolar hemorrhage associated with interstitial pneumonia and systemic sclerosis]
    Mikio Toyoshima
    Department of Internal Medicine Medicine, Inasa Red Cross Hospital
    Nihon Kokyuki Gakkai Zasshi 43:437-41. 2005
    ..We should be aware of this rare but serious complication in the management of interstitial pneumonia associated with systemic sclerosis...
  76. ncbi request reprint [Thyroid involvement of sarcoidosis]
    Tomohiro Uto
    Department of Respiratory Medicine, Hamamatsu University School of Medicine
    Nihon Kokyuki Gakkai Zasshi 46:667-72. 2008
    ..Although the thyroid involvement of sarcoidosis is rare, it should be included in the differential diagnosis with patients with thyroid swelling...
  77. ncbi request reprint [Analysis of CD1 molecules in the process of granuloma formation with sarcoidosis]
    Noriyuki Enomoto
    Second Department of Medicine, Hamamatsu University School of Medicine
    Nihon Kokyuki Gakkai Zasshi 43:10-5. 2005
    ..These data suggest that the presentation of lipid antigens mediated by CD1 molecules on DC is involved in granuloma formation in sarcoidosis...
  78. ncbi request reprint [Cyclosporin treatment of interstitial pneumonia and monitoring of serum concentration]
    Noriyuki Enomoto
    Second Department of Medicine, Hamamatsu University School of Medicine
    Nihon Kokyuki Gakkai Zasshi 42:934-40. 2004
    ..Therefore, the monitoring of the cyclosporin concentration is important especially in progressive cases of interstitial pneumonia that deteriorate despite cyclosporin treatment...
  79. ncbi request reprint Reactive Legionella pneumophila arthritis diagnosed by polymerase chain reaction
    Tateaki Naito
    Rheumatol Int 27:415-6. 2007