Yoshimoto Sekine

Summary

Affiliation: Hamamatsu University School of Medicine
Country: Japan

Publications

  1. pmc The adenosine A2A receptor is associated with methamphetamine dependence/psychosis in the Japanese population
    Hideaki Kobayashi
    Department of Biological Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan
    Behav Brain Funct 6:50. 2010
  2. ncbi request reprint Methamphetamine-related psychiatric symptoms and reduced brain dopamine transporters studied with PET
    Y Sekine
    Department of Psychiatry and Neurology, Hamamatsu School of Medicine, 3600 Handa cho Hamamatsu, 431 3192 Shizuoka, Japan
    Am J Psychiatry 158:1206-14. 2001
  3. ncbi request reprint Brain serotonin transporter density and aggression in abstinent methamphetamine abusers
    Yoshimoto Sekine
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Shizuoka, Japan
    Arch Gen Psychiatry 63:90-100. 2006
  4. doi request reprint Association studies and gene expression analyses of the DISC1-interacting molecules, pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (DBZ), with schizophrenia and with bipolar disorder
    Ayyappan Anitha
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Med Genet B Neuropsychiatr Genet 150:967-76. 2009
  5. doi request reprint Genetic and expression analyses reveal elevated expression of syntaxin 1A ( STX1A) in high functioning autism
    Kazuhiko Nakamura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Int J Neuropsychopharmacol 11:1073-84. 2008
  6. doi request reprint Genetic analyses of roundabout (ROBO) axon guidance receptors in autism
    A Anitha
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:1019-27. 2008
  7. doi request reprint Brain serotonin and dopamine transporter bindings in adults with high-functioning autism
    Kazuhiko Nakamura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Arch Gen Psychiatry 67:59-68. 2010
  8. ncbi request reprint Disruption of reelin signaling attenuates methamphetamine-induced hyperlocomotion
    Hideo Matsuzaki
    Department of Anatomy and Neuroscience, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Eur J Neurosci 25:3376-84. 2007
  9. ncbi request reprint Association of dopamine transporter loss in the orbitofrontal and dorsolateral prefrontal cortices with methamphetamine-related psychiatric symptoms
    Yoshimoto Sekine
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, 431 3192 Shizuoka, Japan
    Am J Psychiatry 160:1699-701. 2003
  10. doi request reprint Short allele of 5-HTTLPR as a risk factor for the development of psychosis in Japanese methamphetamine abusers
    Norikazu Ezaki
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Ann N Y Acad Sci 1139:49-56. 2008

Detail Information

Publications68

  1. pmc The adenosine A2A receptor is associated with methamphetamine dependence/psychosis in the Japanese population
    Hideaki Kobayashi
    Department of Biological Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan
    Behav Brain Funct 6:50. 2010
    ..We therefore hypothesized that variations in the A2A adenosine receptor (ADORA2A) gene modify genetic susceptibility to METH dependence/psychosis...
  2. ncbi request reprint Methamphetamine-related psychiatric symptoms and reduced brain dopamine transporters studied with PET
    Y Sekine
    Department of Psychiatry and Neurology, Hamamatsu School of Medicine, 3600 Handa cho Hamamatsu, 431 3192 Shizuoka, Japan
    Am J Psychiatry 158:1206-14. 2001
    ..The authors measured nucleus accumbens and prefrontal cortex density, in addition to caudate/putamen density, in methamphetamine users and assessed the relation of these measures to the subjects' clinical characteristics...
  3. ncbi request reprint Brain serotonin transporter density and aggression in abstinent methamphetamine abusers
    Yoshimoto Sekine
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Shizuoka, Japan
    Arch Gen Psychiatry 63:90-100. 2006
    ..It remains unknown whether methamphetamine damages serotonin neurons in humans...
  4. doi request reprint Association studies and gene expression analyses of the DISC1-interacting molecules, pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (DBZ), with schizophrenia and with bipolar disorder
    Ayyappan Anitha
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Med Genet B Neuropsychiatr Genet 150:967-76. 2009
    ..We suggest a possible role of PCNT2 in the pathogenesis of schizophrenia. Abnormalities of PCNT2, the centrosomal protein essential for microtubule organization, may be suggested to lead to neurodevelopmental abnormalities...
  5. doi request reprint Genetic and expression analyses reveal elevated expression of syntaxin 1A ( STX1A) in high functioning autism
    Kazuhiko Nakamura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Int J Neuropsychopharmacol 11:1073-84. 2008
    ....
  6. doi request reprint Genetic analyses of roundabout (ROBO) axon guidance receptors in autism
    A Anitha
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:1019-27. 2008
    ..Abnormalities of ROBO may lead to autism either by interfering with serotonergic system, or by disrupting neurodevelopment. To the best of our knowledge, this is the first report relating ROBO with autism...
  7. doi request reprint Brain serotonin and dopamine transporter bindings in adults with high-functioning autism
    Kazuhiko Nakamura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Arch Gen Psychiatry 67:59-68. 2010
    ..Although its neurobiological underpinnings are postulated to lie in abnormalities of the serotoninergic and dopaminergic systems, the details remain unknown...
  8. ncbi request reprint Disruption of reelin signaling attenuates methamphetamine-induced hyperlocomotion
    Hideo Matsuzaki
    Department of Anatomy and Neuroscience, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Eur J Neurosci 25:3376-84. 2007
    ..These results indicate that reelin signaling plays a pivotal role in the dopaminergic system in adult mice, especially in postsynaptic levels...
  9. ncbi request reprint Association of dopamine transporter loss in the orbitofrontal and dorsolateral prefrontal cortices with methamphetamine-related psychiatric symptoms
    Yoshimoto Sekine
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, 431 3192 Shizuoka, Japan
    Am J Psychiatry 160:1699-701. 2003
    ..The authors examined dopamine transporter density in the orbitofrontal cortex, dorsolateral prefrontal cortex, and amygdala in methamphetamine users and assessed the relationship of these measures to the subjects' clinical characteristics...
  10. doi request reprint Short allele of 5-HTTLPR as a risk factor for the development of psychosis in Japanese methamphetamine abusers
    Norikazu Ezaki
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Ann N Y Acad Sci 1139:49-56. 2008
    ..Thus, we suggest a possible role for the 5-HTTLPR polymorphism in MAP psychosis...
  11. ncbi request reprint Gene and expression analyses reveal enhanced expression of pericentrin 2 (PCNT2) in bipolar disorder
    Ayyappan Anitha
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Biol Psychiatry 63:678-85. 2008
    ..PCNT2 has recently been identified as an interacting partner of DISC1. In this study, we investigated the role of PCNT2 in bipolar disorder, by gene expression analysis and genetic association study...
  12. ncbi request reprint Decreased expression of reelin receptor VLDLR in peripheral lymphocytes of drug-naive schizophrenic patients
    Katsuaki Suzuki
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Schizophr Res 98:148-56. 2008
    ..Our findings suggest that peripheral VLDLR mRNA levels may serve as a reliable peripheral biological marker of schizophrenia, and that the reelin-VLDLR/ApoER2 signaling pathway plays a role in the pathophysiology of schizophrenia...
  13. ncbi request reprint An association study between catechol-O-methyl transferase gene polymorphism and methamphetamine psychotic disorder
    Atsuko Suzuki
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, and Ichihara Hospital, Chiba, Japan
    Psychiatr Genet 16:133-8. 2006
    ..This study aimed to investigate whether a functional polymorphism of the catechol-O-methyl transferase gene would be involved in the development of these psychiatric states...
  14. ncbi request reprint Childhood-onset schizophrenia and tryptophan hydroxylase gene polymorphism
    Takahiro Sekizawa
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Shizuoka 431 3192, Japan
    Am J Med Genet B Neuropsychiatr Genet 128:24-6. 2004
    ..47, 95% CI = 0.97-2.37, P = 0.097). There was a nearly doubling of the risk for childhood-onset schizophrenia associated with the AA genotype compared to other genotype groups; OR = 1.97, 95% CI = 0.91-4.22, P = 0.058...
  15. doi request reprint An association study of monoamine oxidase A (MAOA) gene polymorphism in methamphetamine psychosis
    Kazuhiko Nakamura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Higashi ku, Hamamatsu, Shizuoka 431 3192, Japan
    Neurosci Lett 455:120-3. 2009
    ..We found no differences among females. The sample size of females with methamphetamine psychosis was too small to have significant analysis...
  16. ncbi request reprint SNP analyses of growth factor genes EGF, TGFbeta-1, and HGF reveal haplotypic association of EGF with autism
    Takao Toyoda
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu 431 3192, Japan
    Biochem Biophys Res Commun 360:715-20. 2007
    ..No significant SNP or haplotypic associations were observed for TGFbeta1 or HGF. Given the role of EGF in brain and neuronal development, we suggest a possible role of EGF in the pathogenesis of autism...
  17. ncbi request reprint Genetic analyses of the brain-derived neurotrophic factor (BDNF) gene in autism
    Katsuhiko Nishimura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Biochem Biophys Res Commun 356:200-6. 2007
    ..We suggest that BDNF has a possible role in the pathogenesis of autism through its neurotrophic effects on the serotonergic system...
  18. ncbi request reprint Decreased serum levels of platelet-endothelial adhesion molecule (PECAM-1) in subjects with high-functioning autism: a negative correlation with head circumference at birth
    Kenji J Tsuchiya
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Biol Psychiatry 62:1056-8. 2007
    ..This study was undertaken to determine whether serum levels of the adhesion molecules in subjects with high-functioning autism are altered as compared with those of normal controls...
  19. ncbi request reprint Decreased serum levels of hepatocyte growth factor in male adults with high-functioning autism
    Genichi Sugihara
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:412-5. 2007
    ..In this study, we studied whether serum HGF levels are altered in subjects with high-functioning autism...
  20. ncbi request reprint Association analysis of SOD2 variants with methamphetamine psychosis in Japanese and Taiwanese populations
    Kazuhiko Nakamura
    Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Hum Genet 120:243-52. 2006
    ..014 and 0.016, respectively) and in the allelic (P value 0.004 and 0.047, respectively) frequencies. Our results suggest that Ala/Val polymorphism of the SOD2 gene could be associated with the risk of developing methamphetamine psychosis...
  21. ncbi request reprint Metabolite alterations in basal ganglia associated with psychiatric symptoms of abstinent toluene users: a proton MRS study
    Kiyokazu Takebayashi
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Neuropsychopharmacology 29:1019-26. 2004
    ..These findings suggest that long-term toluene use causes membrane disturbance in the basal ganglia, which is associated with residual psychiatric symptoms that persist even after long-term abstinence from toluene use...
  22. ncbi request reprint Decreased serum levels of epidermal growth factor in adult subjects with high-functioning autism
    Katsuaki Suzuki
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Biol Psychiatry 62:267-9. 2007
    ..In this study, we examined whether serum levels of EGF are altered in adult subjects with high-functioning autism...
  23. ncbi request reprint Decreased serum levels of transforming growth factor-beta1 in patients with autism
    Kyoko Okada
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431 3192, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:187-90. 2007
    ..In this study, we studied whether serum levels of TGF-beta1 are altered in patients with autism...
  24. ncbi request reprint Increased levels of serum soluble L-selectin in unmedicated patients with schizophrenia
    Yasuhide Iwata
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Shizuoka, Japan
    Schizophr Res 89:154-60. 2007
    ..For specificity, we also investigated selectin levels in patients with major depression...
  25. doi request reprint Paternal age at birth and high-functioning autistic-spectrum disorder in offspring
    Kenji J Tsuchiya
    Osaka Hamamatsu Joint Research Center for Child Mental Development OHJRC CMD, Hamamatsu University School of Medicine, Hamamatsu 431 3192, Japan
    Br J Psychiatry 193:316-21. 2008
    ..Previous studies have reported the association between advanced paternal age at birth and the risk of autistic-spectrum disorder in offspring, including offspring with intellectual disability...
  26. ncbi request reprint Acetaldehyde adducts in the brain of alcoholics
    Kazuhiko Nakamura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, 1 20 1 Handayama Hamamatsu shi, 431 3192 Shizuoka, Japan
    Arch Toxicol 77:591-3. 2003
    ..We demonstrated acetaldehyde adducts in the frontal cortex and the midbrain of an alcoholics. Our studies showed that an acetaldehyde adduct was produced in the brain of alcoholics...
  27. ncbi request reprint The effects of dentate granule cell destruction on behavioral activity and Fos protein expression induced by systemic MDMA in rats
    Mujun Won
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Shizuoka 431 3192, Japan
    Neurosci Res 46:153-60. 2003
    ....
  28. ncbi request reprint Evidence that variation in the peripheral benzodiazepine receptor (PBR) gene influences susceptibility to panic disorder
    Kazuhiko Nakamura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Med Genet B Neuropsychiatr Genet 141:222-6. 2006
    ..021 and 0.014, respectively). The present study provides new and important evidence that variation in the PBR gene influences susceptibility to PD...
  29. ncbi request reprint Augmentation of milnacipran by risperidone in treatment for major depression
    Kunihiko Tani
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Japan
    Int J Neuropsychopharmacol 7:55-8. 2004
    ..Our experience suggests that an augmentation therapy of milnacipran plus risperidone is useful for treating patients with depression who only partially respond to various types of antidepressants and for treatment-refractory depression...
  30. ncbi request reprint Metabolite alterations in basal ganglia associated with methamphetamine-related psychiatric symptoms. A proton MRS study
    Yoshimoto Sekine
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Neuropsychopharmacology 27:453-61. 2002
    ..These findings suggest that protracted use of methamphetamine may cause metabolite alterations in the basal ganglia. Furthermore, residual psychiatric symptoms may be attributable to the metabolite alterations in the basal ganglia...
  31. ncbi request reprint A transient lesion in splenium of the corpus callosum in a patient with childhood-onset anorexia nervosa
    Katsuhiko Nishimura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Int J Eat Disord 39:527-9. 2006
    ..This is a report of an SCC lesion in a patient with anorexia nervosa (AN)...
  32. ncbi request reprint Early-onset schizophrenia and dopamine-related gene polymorphism
    Yasuhide Iwata
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Am J Med Genet B Neuropsychiatr Genet 116:23-6. 2003
    ..We did not find the relationship between the polymorphism of eight dopamine-related genes and susceptibility to EOS in a Japanese sample...
  33. ncbi request reprint [Advances in neuroimaging research on Asperger syndrome]
    Genichi Sugihara
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine
    Nihon Rinsho 65:449-52. 2007
    ..SPECT and PET studies suggested that abnormalities of the serotonergic system, in addition to decreased regional cerebral blood flow in the frontal and temporal lobes, are implicated in the pathophysiology of ASD...
  34. ncbi request reprint Acute and repeated administration of fluoxetine, citalopram, and paroxetine significantly alters the activity of midbrain dopamine neurons in rats: an in vivo electrophysiological study
    Yoshimoto Sekine
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Synapse 61:72-7. 2007
    ..Overall, our results indicate that the systemic administration of SSRI alters the activity of midbrain DA neurons with differential effects on VTA compared with SNC DA neurons...
  35. ncbi request reprint CYP2E1 and clinical features in alcoholics
    Kazuhiko Nakamura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Neuropsychobiology 47:86-9. 2003
    ..05). In regard to liver disease or self-consciousness, this was at a trend level (p = 0.08). We have shown that the genotypes of CYP2E1 are associated with clinical features of alcoholics...
  36. ncbi request reprint Increased serum levels of glutamate in adult patients with autism
    Atsuko Shinohe
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431 3192, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1472-7. 2006
    ..In this study, we studied whether amino acids (glutamate, glutamine, glycine, D-serine, and L-serine) related to glutamatergic neurotransmission are altered in serum of adult patients with autism...
  37. ncbi request reprint [Asperger syndrome: neuroimaging ]
    Genichi Sugihara
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine
    Nihon Rinsho 65:398-400. 2007
  38. ncbi request reprint Linkage disequilibrium analysis of the CHRNA7 gene and its partially duplicated region in schizophrenia
    Yasuhide Iwata
    Division of Psychological Medicine, Institute of Psychiatry, 1 Windsor Walk, Denmark Hill, London, UK
    Neurosci Res 57:194-202. 2007
    ..However, we could not exclude the possibility of a weak genetic effect due to the small sample size. Analyses of larger samples and higher-density markers, particularly around SNP9 (IVS4-1912), are still needed...
  39. ncbi request reprint Tacrolimus, a specific inhibitor of calcineurin, modifies the locomotor activity of quinpirole, but not that of SKF82958, in male rats
    Masatsuna Sakanoue
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, 1 20 1 Handayama, 431 3192 Shizuoka, Hamamatsu, Japan
    Eur J Pharmacol 438:93-7. 2002
    ..5, 1, 2 or 5 mg/kg of tacrolimus compared to vehicle-treated animals. Our results suggest that calcineurin may play a role in the alteration of locomotor activity produced by dopamine D(2)/D(3) receptors, but not dopamine D(1) receptors...
  40. ncbi request reprint The glycine transporter 1 gene (GLYT1) is associated with methamphetamine-use disorder
    Yukitaka Morita
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences 2 5 1 Shikata cho, Okayama, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:54-8. 2008
    ..000039, odds ratio: 2.04). The present findings indicate that genetic variation of the GLYT1 gene may contribute to individual vulnerability to methamphetamine dependence and psychosis...
  41. ncbi request reprint Study of association between alpha-synuclein gene polymorphism and methamphetamine psychosis/dependence
    Hideaki Kobayashi
    Department of Molecular Psychiatry, Tokyo Institute of Psychiatry, Japan
    Ann N Y Acad Sci 1025:325-34. 2004
    ..Further analyses are necessary to clarify the gender difference, by using a larger sample size and/or different ethnic groups, as well as functional variations in the alpha-synuclein gene...
  42. ncbi request reprint Gene polymorphisms of the mu opioid receptor in methamphetamine abusers
    Soichiro Ide
    Department of Molecular Psychiatry, Tokyo Institute of Psychiatry, Japan
    Ann N Y Acad Sci 1025:316-24. 2004
    ..Further analysis should be capable of identifying associations between the OPRM variations and MAP dependence/psychosis...
  43. doi request reprint Association study between polymorphisms in glutathione-related genes and methamphetamine use disorder in a Japanese population
    Tasuku Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:1040-6. 2008
    ..The present study suggests that the polymorphism of the GSTT1 gene might be a genetic risk factor of the development of METH psychosis in a Japanese population...
  44. ncbi request reprint Neuromechanism of developing methamphetamine psychosis: a neuroimaging study
    Masaomi Iyo
    Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba, Japan
    Ann N Y Acad Sci 1025:288-95. 2004
    ..These findings suggest that long-term use of MAP causes abnormal cerebral blood flow patterns, reduction of brain dopamine transporter density, and metabolite alteration, which may be closely related to a susceptibility to MAP psychosis...
  45. doi request reprint Reduced CYP2D6 activity is a negative risk factor for methamphetamine dependence
    Kyohei Otani
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikata cho 2 5 1, Okayama 700 8558, Japan
    Neurosci Lett 434:88-92. 2008
    ..0212), with an odds ratio of 0.62 (95% confidence interval: 0.51-0.76). The present study demonstrated that reduced CYP2D6 activity was a negative risk factor for methamphetamine dependence...
  46. doi request reprint Genome-wide association for methamphetamine dependence: convergent results from 2 samples
    George R Uhl
    Molecular Neurobiology Branch, National Institutes of Health Intramural Program, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Arch Gen Psychiatry 65:345-55. 2008
    ..We can improve understanding of human methamphetamine dependence, and possibly our abilities to prevent and treat this devastating disorder, by identifying genes whose allelic variants predispose to methamphetamine dependence...
  47. pmc Methamphetamine causes microglial activation in the brains of human abusers
    Yoshimoto Sekine
    Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 28:5756-61. 2008
    ..These results suggest that chronic self-administration of methamphetamine can cause reactive microgliosis in the brains of human methamphetamine abusers, a level of activation that appears to subside over longer periods of abstinence...
  48. ncbi request reprint Association analysis of FEZ1 variants with schizophrenia in Japanese cohorts
    Kazuo Yamada
    RIKEN Brain Science Institute, Laboratory for Molecular Psychiatry, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Biol Psychiatry 56:683-90. 2004
    ..We recently identified FEZ1 as an interacting partner for DISC1. To investigate the role of FEZ1 in schizophrenia and bipolar disorder, case-control association analyses were conducted in Japanese cohorts...
  49. ncbi request reprint Association study between brain-derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan
    Kanako Itoh
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Am J Med Genet B Neuropsychiatr Genet 132:70-3. 2005
    ..This article contains supplementary material, which may be viewed at the American Journal of Medical Genetics website at http://www.interscience.wiley.com/jpages/0148-7299:1/suppmat/index.html...
  50. ncbi request reprint Association between schizophrenia with ocular misalignment and polyalanine length variation in PMX2B
    Tomoko Toyota
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Hum Mol Genet 13:551-61. 2004
    ....
  51. ncbi request reprint Identification of functional polymorphisms in the promoter region of the human PICK1 gene and their association with methamphetamine psychosis
    Daisuke Matsuzawa
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Am J Psychiatry 164:1105-14. 2007
    ..Based on the interaction of PICK1 with dopamine transporter, it is of particular interest to investigate the association between the PICK1 gene and methamphetamine abusers...
  52. ncbi request reprint Microglial activation and dopamine terminal loss in early Parkinson's disease
    Yasuomi Ouchi
    Positron Medical Center, Hamamatsu Medical Center, Hamakita, Japan
    Ann Neurol 57:168-75. 2005
    ....
  53. ncbi request reprint The dysbindin gene (DTNBP1) is associated with methamphetamine psychosis
    Makiko Kishimoto
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Biol Psychiatry 63:191-6. 2008
    ..DTNBP1 may confer susceptibility to psychotic symptoms in various psychiatric disorders besides schizophrenia...
  54. ncbi request reprint Association between gene polymorphisms of SLC22A3 and methamphetamine use disorder
    Nagisa Aoyama
    Department of Medical Technology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Alcohol Clin Exp Res 30:1644-9. 2006
    ..Moreover, SLC22A3 (which encodes OCT3) is a candidate gene for MAP dependence because it is located within a chromosomal region associated with substance dependence...
  55. ncbi request reprint Association analysis of delta-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis
    Hideaki Kobayashi
    Department of Psychobiology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Am J Med Genet B Neuropsychiatr Genet 141:482-6. 2006
    ..These results suggest that the OPRD1 gene variants may not be a factor in vulnerability to MAP dependence/psychosis...
  56. ncbi request reprint Functional polymorphism of the NQO2 gene is associated with methamphetamine psychosis
    Shintaro Ohgake
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Addict Biol 10:145-8. 2005
    ..038) difference between patients with prolonged-type MAP psychosis and controls. This study suggests that the NQO2 gene polymorphism contributes to the aetiology of MAP-related psychosis in Japanese...
  57. ncbi request reprint Genetic variant of prodynorphin gene is risk factor for methamphetamine dependence
    Akira Nomura
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Neurosci Lett 400:158-62. 2006
    ..83, 95% ci=1.24-2.68)...
  58. ncbi request reprint Positive association of AKT1 haplotype to Japanese methamphetamine use disorder
    Masashi Ikeda
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Int J Neuropsychopharmacol 9:77-81. 2006
    ..Further investigation of these associations, together with evidence from previous animal studies, may open the way to elucidation of the pathophysiology of this condition...
  59. ncbi request reprint The X-box binding protein 1 (XBP1) gene is not associated with methamphetamine dependence
    Yukitaka Morita
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, Japan
    Neurosci Lett 383:194-8. 2005
    ..Because the polymorphism is located in the promoter region of the XBP-1 gene and affects transcription activity of the gene, it is unlikely that dysfunction of XBP-1 may induces susceptibility to methamphetamine dependence...
  60. ncbi request reprint A functional glutathione S-transferase P1 gene polymorphism is associated with methamphetamine-induced psychosis in Japanese population
    Tasuku Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, Inohana, Chiba, Japan
    Am J Med Genet B Neuropsychiatr Genet 135:5-9. 2005
    ..Our findings suggest that the polymorphism (Ile105Val) on exon 5 of the GSTP1 gene may contribute to a vulnerability to psychosis associated with MAP abuse in Japanese population...
  61. ncbi request reprint A nonsynonymous polymorphism in the human fatty acid amide hydrolase gene did not associate with either methamphetamine dependence or schizophrenia
    Yukitaka Morita
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Neurosci Lett 376:182-7. 2005
    ..Because the Pro129Thr polymorphism reduces enzyme instability, it is unlikely that dysfunction of FAAH and enhanced endocannabinoid system induce susceptibility to either methamphetamine dependence/psychosis or schizophrenia...
  62. ncbi request reprint Perospirone is a new generation antipsychotic: evidence from a positron emission tomography study of serotonin 2 and D2 receptor occupancy in the living human brain
    Yoshimoto Sekine
    J Clin Psychopharmacol 26:531-3. 2006
  63. pmc Manic-switch induced by fluvoxamine in abstinent pure methamphetamine abusers
    Mujun Won
    J Psychiatry Neurosci 28:134-5. 2003
  64. ncbi request reprint Orthostatic posture affects brain hemodynamics and metabolism in cerebrovascular disease patients with and without coronary artery disease: a positron emission tomography study
    Yasuomi Ouchi
    Positron Medical Center, Hamamatsu Medical Center, Hamakita, Japan
    Neuroimage 24:70-81. 2005
    ....
  65. ncbi request reprint Association between the glutathione S-transferase M1 gene deletion and female methamphetamine abusers
    Hiroki Koizumi
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Am J Med Genet B Neuropsychiatr Genet 126:43-5. 2004
    ..007, odds ratio: 2.77, 95% CI 1.30-5.89) higher than that of male abusers with deletion alleles. These findings suggest that GSTM1 gene deletion may contribute to a vulnerability to MAP abuse in female subjects, but not in male subjects...
  66. ncbi request reprint A novel scale including strabismus and 'cuspidal ear' for distinguishing schizophrenia patients from controls using minor physical anomalies
    Kiyoshi Yoshitsugu
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama, Japan
    Psychiatry Res 145:249-58. 2006
    ..The scale may also facilitate the identification of schizophrenia susceptibility genetic/environmental factors by stratifying etiologically heterogeneous patients according to physical abnormalities...
  67. ncbi request reprint Effective adjunctive use of pergolide with quetiapine for cognitive impairment and negative symptoms in schizophrenia
    Yoshimoto Sekine
    J Clin Psychopharmacol 25:281-3. 2005
  68. ncbi request reprint Reduced serum levels of brain-derived neurotrophic factor in adult male patients with autism
    Kenji Hashimoto
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1529-31. 2006
    ..In this study, we studied whether serum levels of BDNF are altered in patients with autism...