Yasuomi Ouchi

Summary

Affiliation: Hamamatsu Medical Center
Country: Japan

Publications

  1. ncbi request reprint Orthostatic posture affects brain hemodynamics and metabolism in cerebrovascular disease patients with and without coronary artery disease: a positron emission tomography study
    Yasuomi Ouchi
    Positron Medical Center, Hamamatsu Medical Center, Hamakita, Japan
    Neuroimage 24:70-81. 2005
  2. ncbi request reprint Changes in cerebral blood flow under the prone condition with and without massage
    Yasuomi Ouchi
    Positron Medical Center, Hamamatsu Medical Center, 5000 Hirakuchi, Hamamatsu 434 0041, Japan
    Neurosci Lett 407:131-5. 2006
  3. ncbi request reprint In vivo presynaptic and postsynaptic striatal dopamine functions in idiopathic normal pressure hydrocephalus
    Yasuomi Ouchi
    Positron Medical Center, Hamamatsu Medical Center, Hamamatsu, Japan
    J Cereb Blood Flow Metab 27:803-10. 2007
  4. ncbi request reprint Neural substrates in judgment process while playing go: a comparison of amateurs with professionals
    Yasuomi Ouchi
    Positron Medical Center, Hamamatsu Medical Center, 5000 Hirakuchi, Hamakita, 434 0041, Japan
    Brain Res Cogn Brain Res 23:164-70. 2005
  5. ncbi request reprint Microglial activation and dopamine terminal loss in early Parkinson's disease
    Yasuomi Ouchi
    Positron Medical Center, Hamamatsu Medical Center, Hamakita, Japan
    Ann Neurol 57:168-75. 2005
  6. ncbi request reprint Activation in the premotor cortex during mental calculation in patients with Alzheimer's disease: relevance of reduction in posterior cingulate metabolism
    Yasuomi Ouchi
    Positron Medical Center, Hamamatsu Medical Center, 5000 Hirakuchi, Hamakita 434 0041, Japan
    Neuroimage 22:155-63. 2004
  7. ncbi request reprint Imaging of gynecologic tumors: comparison of (11)C-choline PET with (18)F-FDG PET
    Tatsuo Torizuka
    Positron Medical Center, Hamamatsu Medical Center, Hamakita, Japan
    J Nucl Med 44:1051-6. 2003
  8. doi request reprint Brain serotonin and dopamine transporter bindings in adults with high-functioning autism
    Kazuhiko Nakamura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Arch Gen Psychiatry 67:59-68. 2010
  9. doi request reprint Genetic analyses of roundabout (ROBO) axon guidance receptors in autism
    A Anitha
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:1019-27. 2008
  10. ncbi request reprint FDG PET for the assessment of myometrial infiltration in clinical stage I uterine corpus cancer
    Tatsuo Torizuka
    Positron Medical Center, Hamamatsu Medical Center, Japan
    Nucl Med Commun 27:481-7. 2006

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Orthostatic posture affects brain hemodynamics and metabolism in cerebrovascular disease patients with and without coronary artery disease: a positron emission tomography study
    Yasuomi Ouchi
    Positron Medical Center, Hamamatsu Medical Center, Hamakita, Japan
    Neuroimage 24:70-81. 2005
    ....
  2. ncbi request reprint Changes in cerebral blood flow under the prone condition with and without massage
    Yasuomi Ouchi
    Positron Medical Center, Hamamatsu Medical Center, 5000 Hirakuchi, Hamamatsu 434 0041, Japan
    Neurosci Lett 407:131-5. 2006
    ..To conclude, prone posture itself can stimulate the precuneus region to raise awareness, and the light massage on the back may help accommodate the brain to comfortable stimulation...
  3. ncbi request reprint In vivo presynaptic and postsynaptic striatal dopamine functions in idiopathic normal pressure hydrocephalus
    Yasuomi Ouchi
    Positron Medical Center, Hamamatsu Medical Center, Hamamatsu, Japan
    J Cereb Blood Flow Metab 27:803-10. 2007
    ..Postsynaptic D2 receptor hypoactivity in the dorsal putamen may predict the severity of gait impairment in iNPH...
  4. ncbi request reprint Neural substrates in judgment process while playing go: a comparison of amateurs with professionals
    Yasuomi Ouchi
    Positron Medical Center, Hamamatsu Medical Center, 5000 Hirakuchi, Hamakita, 434 0041, Japan
    Brain Res Cogn Brain Res 23:164-70. 2005
    ..These findings suggested the cerebellum and precuneus play important roles in processing of accurate judgment by visual imagery and nonmotor learning memory processes in professional go players...
  5. ncbi request reprint Microglial activation and dopamine terminal loss in early Parkinson's disease
    Yasuomi Ouchi
    Positron Medical Center, Hamamatsu Medical Center, Hamakita, Japan
    Ann Neurol 57:168-75. 2005
    ....
  6. ncbi request reprint Activation in the premotor cortex during mental calculation in patients with Alzheimer's disease: relevance of reduction in posterior cingulate metabolism
    Yasuomi Ouchi
    Positron Medical Center, Hamamatsu Medical Center, 5000 Hirakuchi, Hamakita 434 0041, Japan
    Neuroimage 22:155-63. 2004
    ..These results suggest that the premotor cortex plays a compensatory role in executing mental calculations in AD patients with reduced posteromedial functions, which might reflect the dynamic aspect of the pathophysiology of early AD...
  7. ncbi request reprint Imaging of gynecologic tumors: comparison of (11)C-choline PET with (18)F-FDG PET
    Tatsuo Torizuka
    Positron Medical Center, Hamamatsu Medical Center, Hamakita, Japan
    J Nucl Med 44:1051-6. 2003
    ..This study was designed to compare the value of PET using (11)C-choline with that of PET using (18)F-FDG for the diagnosis of gynecologic tumors...
  8. doi request reprint Brain serotonin and dopamine transporter bindings in adults with high-functioning autism
    Kazuhiko Nakamura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Arch Gen Psychiatry 67:59-68. 2010
    ..Although its neurobiological underpinnings are postulated to lie in abnormalities of the serotoninergic and dopaminergic systems, the details remain unknown...
  9. doi request reprint Genetic analyses of roundabout (ROBO) axon guidance receptors in autism
    A Anitha
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:1019-27. 2008
    ..Abnormalities of ROBO may lead to autism either by interfering with serotonergic system, or by disrupting neurodevelopment. To the best of our knowledge, this is the first report relating ROBO with autism...
  10. ncbi request reprint FDG PET for the assessment of myometrial infiltration in clinical stage I uterine corpus cancer
    Tatsuo Torizuka
    Positron Medical Center, Hamamatsu Medical Center, Japan
    Nucl Med Commun 27:481-7. 2006
    ..We evaluated the value of positron emission tomography with 2-[(18)F]fluoro-2-deoxy-D-glucose (FDG PET) for estimating the myometrial invasion in uterine corpus cancer...
  11. doi request reprint Genetic and expression analyses reveal elevated expression of syntaxin 1A ( STX1A) in high functioning autism
    Kazuhiko Nakamura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Int J Neuropsychopharmacol 11:1073-84. 2008
    ....
  12. doi request reprint Alterations in α4β2 nicotinic receptors in cognitive decline in Alzheimer's aetiopathology
    Hiroyuki Okada
    1 Central Research Laboratory, Hamamatsu Photonics K K, Hamamatsu, Japan
    Brain 136:3004-17. 2013
    ....
  13. doi request reprint Benign hereditary chorea: dopaminergic brain imaging in patients with a novel intronic NKX2.1 gene mutation
    Takashi Konishi
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1, Handayama, Hamamatsu, 431 3192, Japan
    J Neurol 260:207-13. 2013
    ..The molecular brain imaging and therapeutic response may help elucidate the pathophysiological mechanism of the motor control in the BHC-associated NKX2.1 mutation...
  14. pmc Effect of subthalamic nucleus stimulation during exercise on the mesolimbocortical dopaminergic region in Parkinson's disease: a positron emission tomography study
    Takao Nozaki
    Department of Neurosurgery, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Cereb Blood Flow Metab 33:415-21. 2013
    ....
  15. doi request reprint Progression from unilateral to bilateral parkinsonism in early Parkinson disease: implication of mesocortical dopamine dysfunction by PET
    Shunsuke Yagi
    Molecular Imaging Frontier Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Nucl Med 51:1250-7. 2010
    ....
  16. ncbi request reprint [Measurement of radiation exposure to a PET institution driver from patients injected with FDG]
    Fumitoshi Nakamura
    Positron Medical Center, Hamamatsu Medical Center
    Nihon Hoshasen Gijutsu Gakkai Zasshi 62:1105-10. 2006
    ..1 m) and 0.92 mSv (1.9 m). According to our data, the measured dose was 20% lower than the estimated dose. This discrepancy may be due to the difference between the volume source (measured dose) and point source (estimated dose)...
  17. doi request reprint Microglial activation in young adults with autism spectrum disorder
    Katsuaki Suzuki
    Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    JAMA Psychiatry 70:49-58. 2013
    ..However, to our knowledge, no information is available on the patterns of distribution of microglial activation in the brain in ASD...
  18. doi request reprint Single 20-second acquisition of deep-inspiration breath-hold PET/CT: clinical feasibility for lung cancer
    Tatsuo Torizuka
    Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Nucl Med 50:1579-84. 2009
    ..This study was designed to compare tumor (18)F-FDG uptake between a single 20-s acquisition of deep-inspiration breath-hold PET/CT and free-breathing PET/CT for lung cancer...
  19. ncbi request reprint Effect of simple motor performance on regional dopamine release in the striatum in Parkinson disease patients and healthy subjects: a positron emission tomography study
    Yasuomi Ouchi
    Positron Medical Center, Department of Neurology, Hamamatsu Medical Center, Hamamatsu, Japan
    J Cereb Blood Flow Metab 22:746-52. 2002
    ..Lack of the crossed pattern and ipsilateral increase in dopamine release in the dorsal striatum during the unilateral limb movement may reflect the pathophysiology for hypokinetic and insufficient coordinating movement in PD...
  20. ncbi request reprint Early therapy monitoring with FDG-PET in aggressive non-Hodgkin's lymphoma and Hodgkin's lymphoma
    Tatsuo Torizuka
    Positron Medical Center, Hamamatsu Medical Center, 5000 Hirakuchi, 434 0041 Hamakita, Shizuoka, Japan
    Eur J Nucl Med Mol Imaging 31:22-8. 2004
    ..In conclusion, when performed early during chemotherapy, FDG-PET may be predictive of clinical outcome and allows differentiation of responders from non-responders in cases of aggressive lymphoma...
  21. doi request reprint In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer's disease
    Masamichi Yokokura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Eur J Nucl Med Mol Imaging 38:343-51. 2011
    ..The purpose of the present study was to clarify the in vivo relationship between Aβ accumulation and neuroinflammation in those specific brain regions in early AD...
  22. doi request reprint Prognostic value of 18F-FDG PET in patients with head and neck squamous cell cancer
    Tatsuo Torizuka
    Positron Medical Center, Hamamatsu Medical Center, Hamamatsu, Japan
    AJR Am J Roentgenol 192:W156-60. 2009
    ..Furthermore, a prognostic maximum SUV was determined with univariate and bivariate analyses...
  23. pmc In vivo mesolimbic D2/3 receptor binding predicts posttherapeutic clinical responses in restless legs syndrome: a positron emission tomography study
    Yumi Oboshi
    Department of Biofunctional Imaging, Medical Photonics Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Cereb Blood Flow Metab 32:654-62. 2012
    ..The present results suggest that alterations in mesolimbic D2/3 receptor function reflect the pathophysiology of iRLS, and the baseline availability of D2/3 receptors may predict the clinical outcome after D2/3 agonist treatment...
  24. ncbi request reprint Striatal D2 receptor availability after shunting in idiopathic normal pressure hydrocephalus
    Teiji Nakayama
    Department of Neurosurgery, Hamamatsu Medical Center, Hamamatsu, Japan
    J Nucl Med 48:1981-6. 2007
    ..Here, we investigated the plasticity of D(2) receptor in treating iNPH patients with ventriculoperitoneal (VP) shunting using PET with (11)C-raclopride and discuss the contribution of D(2) receptor to the pathophysiology of iNPH...
  25. ncbi request reprint Association of dopamine transporter loss in the orbitofrontal and dorsolateral prefrontal cortices with methamphetamine-related psychiatric symptoms
    Yoshimoto Sekine
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, 431 3192 Shizuoka, Japan
    Am J Psychiatry 160:1699-701. 2003
    ..The authors examined dopamine transporter density in the orbitofrontal cortex, dorsolateral prefrontal cortex, and amygdala in methamphetamine users and assessed the relationship of these measures to the subjects' clinical characteristics...
  26. ncbi request reprint Cerebral hemodynamics evaluation by near-infrared time-resolved spectroscopy: correlation with simultaneous positron emission tomography measurements
    Etsuko Ohmae
    Central Research Laboratory, Hamamatsu Photonics K K, 5000 Hirakuchi, Hamamatsu, Shizuoka 434 8601, Japan
    Neuroimage 29:697-705. 2006
    ..These results demonstrated that NIR-TRS with 4 cm of optode spacing could measure cerebral hemodynamic responses optimally and quantitatively...
  27. ncbi request reprint Ovarian cancer recurrence: role of whole-body positron emission tomography using 2-[fluorine-18]-fluoro-2-deoxy- D-glucose
    Tatsuo Torizuka
    Positron Medical Center, Hamamatsu Medical Center, 5000, Hirakuchi, Hamakita, Shizuoka, 434 0041, Japan
    Eur J Nucl Med Mol Imaging 29:797-803. 2002
    ..In conclusion, our preliminary study demonstrates that FDG-PET may be accurate and useful for the detection of tumour recurrence when conventional imaging is inconclusive or negative, especially in patients with abnormal CA125 levels...
  28. ncbi request reprint Altered brain serotonin transporter and associated glucose metabolism in Alzheimer disease
    Yasuomi Ouchi
    Laboratory of Human Imaging Research, Molecular Imaging Frontier Research Center, Hamamatsu University School of Medicine, Higashi ku, Hamamatsu, Japan
    J Nucl Med 50:1260-6. 2009
    ....
  29. ncbi request reprint GABA-A receptor impairment in cerebellar ataxia with anti-glutamic acid decarboxylase antibodies
    Yasushi Hosoi
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1, Handayama, Hamamatsu, 431 3192, Japan
    J Neurol 260:3086-92. 2013
    ....
  30. ncbi request reprint [Physical property of emission data in simultaneous emission/transmission acquisition: evaluation for clinical application]
    Fumitoshi Nakamura
    Positron Medical Center, Hamamatsu Medical Center
    Nihon Hoshasen Gijutsu Gakkai Zasshi 61:826-32. 2005
    ..In the present study using a phantom, the physical property of emission data in SET acquisition was evaluated in comparison with that in separate scan...
  31. pmc New computer-aided diagnosis of dementia using positron emission tomography: brain regional sensitivity-mapping method
    Akihiro Kakimoto
    PET Medical Application Group, Central Research Laboratory, Hamamatsu Photonics K K, Branch 5000, Hamamatsu, Japan
    PLoS ONE 6:e25033. 2011
    ..The purpose of this study is to investigate its accuracy to differentiate patients with Alzheimer's disease (AD) or mild cognitive impairment (MCI) from normal adults (NL)...
  32. doi request reprint Functional brain imaging in glucocerebrosidase mutation carriers with and without parkinsonism
    Satoshi Kono
    First Department of Medicine, Hamamatsu University School of Medicine, Handayama, Hamamatsu, Japan
    Mov Disord 25:1823-9. 2010
    ..The hypometabolism in the SMA may, therefore, be involved in the clinical characteristics of parkinsonism associated with GBA mutations when the carriers manifest parkinsonism...
  33. pmc Pre-task prefrontal activation during cognitive processes in aging: a near-infrared spectroscopy study
    Yumi Oboshi
    Department of Biofunctional Imaging, Medical Photonics Research Center, Hamamatsu University School of Medicine, Hamamatsu, Japan Department of Occupational Therapy, Faculty of Health and Medical Sciences, Tokoha University, Hamamatsu, Japan
    PLoS ONE 9:e98779. 2014
    ..The purpose of the present study was to investigate changes in voluntary pre-task activation as a result of aging using a paradigm that includes a longer intertrial interval (e.g., 30 sec) than has been used in previous studies...
  34. doi request reprint SPG3A-linked hereditary spastic paraplegia associated with cerebral glucose hypometabolism
    Tatsuhiro Terada
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Ann Nucl Med 27:303-8. 2013
    ....
  35. doi request reprint A review of the default mode network in aging and dementia based on molecular imaging
    Yasuomi Ouchi
    Department of Biofunctional Imaging, Medical Photonics Research Center Hamamatsu University School of Medicine, Hamamatsu, Japan
    Rev Neurosci 23:263-8. 2012
    ..As literature on fMRI-based DMN activity is profuse, here, we discuss the pathophysiological aspect of the DMN from a molecular imaging viewpoint...
  36. pmc Reduction of [11C](+)3-MPB binding in brain of chronic fatigue syndrome with serum autoantibody against muscarinic cholinergic receptor
    Shigeyuki Yamamoto
    Department of Physiology, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka, Japan
    PLoS ONE 7:e51515. 2012
    ....
  37. ncbi request reprint Genetic analyses of the brain-derived neurotrophic factor (BDNF) gene in autism
    Katsuhiko Nishimura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Biochem Biophys Res Commun 356:200-6. 2007
    ..We suggest that BDNF has a possible role in the pathogenesis of autism through its neurotrophic effects on the serotonergic system...
  38. pmc Methamphetamine causes microglial activation in the brains of human abusers
    Yoshimoto Sekine
    Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 28:5756-61. 2008
    ..These results suggest that chronic self-administration of methamphetamine can cause reactive microgliosis in the brains of human methamphetamine abusers, a level of activation that appears to subside over longer periods of abstinence...
  39. ncbi request reprint Neural substrates of human facial expression of pleasant emotion induced by comic films: a PET Study
    Masao Iwase
    Psychiatry, and Department of Clinical Neuroscience, Osaka University Graduate School of Medicine, Suita Shi, Osaka 565 0871, Japan
    Neuroimage 17:758-68. 2002
    ..05, corrected). We demonstrated distinct neural substrates of emotional and volitional facial expression and defined cognitive and experiential processes of a pleasant emotion, laughter/smile...
  40. ncbi request reprint Database of normal human cerebral blood flow, cerebral blood volume, cerebral oxygen extraction fraction and cerebral metabolic rate of oxygen measured by positron emission tomography with 15O-labelled carbon dioxide or water, carbon monoxide and oxygen:
    Hiroshi Ito
    Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, Akita, Japan
    Eur J Nucl Med Mol Imaging 31:635-43. 2004
    ..However, the overall inter-individual variation in CBF, CBV, OEF and CMRO(2) was acceptably small. Building a database of normal cerebral haemodynamics obtained by the(15)O-PET methods may be practicable...
  41. ncbi request reprint Reduction of serotonin transporters of patients with chronic fatigue syndrome
    Shigeyuki Yamamoto
    Department of Physiology, Osaka City University Graduate School of Medicine, 1 4 3 Asahimachi, Abeno Ku, Osaka 545 8585, Japan
    Neuroreport 15:2571-4. 2004
    ..Therefore, an alteration of serotonergic system in the rostral anterior cingulate plays a key role in pathophysiology of chronic fatigue syndrome...
  42. ncbi request reprint Dopaminergic neuronal dysfunction associated with parkinsonism in both a Gaucher disease patient and a carrier
    Satoshi Kono
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    J Neurol Sci 252:181-4. 2007
    ....
  43. ncbi request reprint Perospirone is a new generation antipsychotic: evidence from a positron emission tomography study of serotonin 2 and D2 receptor occupancy in the living human brain
    Yoshimoto Sekine
    J Clin Psychopharmacol 26:531-3. 2006
  44. ncbi request reprint Brain serotonin transporter density and aggression in abstinent methamphetamine abusers
    Yoshimoto Sekine
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Shizuoka, Japan
    Arch Gen Psychiatry 63:90-100. 2006
    ..It remains unknown whether methamphetamine damages serotonin neurons in humans...
  45. ncbi request reprint Glucose and oxygen hypometabolism in aceruloplasminemia brains
    Hiroaki Miyajima
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu
    Intern Med 41:186-90. 2002
    ..To clarify the free radical-mediated tissue injury caused by intracellular iron accumulation through mitochondrial dysfunction...
  46. ncbi request reprint [Advances in neuroimaging research on Asperger syndrome]
    Genichi Sugihara
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine
    Nihon Rinsho 65:449-52. 2007
    ..SPECT and PET studies suggested that abnormalities of the serotonergic system, in addition to decreased regional cerebral blood flow in the frontal and temporal lobes, are implicated in the pathophysiology of ASD...