Hirotoshi Nakamura

Summary

Affiliation: Hamamatsu University School of Medicine
Country: Japan

Publications

  1. pmc A two-day-old hyperthyroid neonate with thyroid hormone resistance born to a mother with well-controlled Graves' disease: a case report
    Shuichi Yatsuga
    Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka, 830 0011, Japan
    J Med Case Rep 6:246. 2012
  2. ncbi request reprint Comparison of methimazole and propylthiouracil in patients with hyperthyroidism caused by Graves' disease
    Hirotoshi Nakamura
    Department of Internal Medicine II, Hamamatsu University School of Medicine, Handayama 1 20 1, Hamamatsu, Shizuoka, Japan
    J Clin Endocrinol Metab 92:2157-62. 2007
  3. doi request reprint Mouse CD11bhigh lung dendritic cells have more potent capability to induce IgA than CD103+ lung dendritic cells in vitro
    Yuzo Suzuki
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama Higashi ku, Hamamatsu, Shizuoka, Japan
    Am J Respir Cell Mol Biol 46:773-80. 2012
  4. pmc Liganded thyroid hormone receptor inhibits phorbol 12-O-tetradecanoate-13-acetate-induced enhancer activity via firefly luciferase cDNA
    Hiroko Misawa
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    PLoS ONE 7:e28916. 2012
  5. ncbi request reprint Functions of PIT1 in GATA2-dependent transactivation of the thyrotropin beta promoter
    Yumiko Kashiwabara
    Department of Internal Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan
    J Mol Endocrinol 42:225-37. 2009
  6. pmc Serum indoleamine 2,3-dioxygenase activity predicts prognosis of pulmonary tuberculosis
    Yuzo Suzuki
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Clin Vaccine Immunol 19:436-42. 2012
  7. doi request reprint Mouse lung CD103+ and CD11bhigh dendritic cells preferentially induce distinct CD4+ T-cell responses
    Kazuki Furuhashi
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Respir Cell Mol Biol 46:165-72. 2012
  8. doi request reprint Serum activity of indoleamine 2,3-dioxygenase predicts prognosis of community-acquired pneumonia
    Yuzo Suzuki
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Infect 63:215-22. 2011
  9. pmc Essential role of TEA domain transcription factors in the negative regulation of the MYH 7 gene by thyroid hormone and its receptors
    Hiroyuki Iwaki
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    PLoS ONE 9:e88610. 2014
  10. doi request reprint Enhancement of protective immunity against intracellular bacteria using type-1 polarized dendritic cell (DC) vaccine
    Masato Kono
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Vaccine 30:2633-9. 2012

Collaborators

Detail Information

Publications73

  1. pmc A two-day-old hyperthyroid neonate with thyroid hormone resistance born to a mother with well-controlled Graves' disease: a case report
    Shuichi Yatsuga
    Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka, 830 0011, Japan
    J Med Case Rep 6:246. 2012
    ..abstract:..
  2. ncbi request reprint Comparison of methimazole and propylthiouracil in patients with hyperthyroidism caused by Graves' disease
    Hirotoshi Nakamura
    Department of Internal Medicine II, Hamamatsu University School of Medicine, Handayama 1 20 1, Hamamatsu, Shizuoka, Japan
    J Clin Endocrinol Metab 92:2157-62. 2007
    ..Although methimazole (MMI) and propylthiouracil (PTU) have long been used to treat hyperthyroidism caused by Graves' disease (GD), there is still no clear conclusion about the choice of drug or appropriate initial doses...
  3. doi request reprint Mouse CD11bhigh lung dendritic cells have more potent capability to induce IgA than CD103+ lung dendritic cells in vitro
    Yuzo Suzuki
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama Higashi ku, Hamamatsu, Shizuoka, Japan
    Am J Respir Cell Mol Biol 46:773-80. 2012
    ..These findings suggest that, of the two major LDCs, CD11b(high) LDCs more efficiently induce IgA than do CD103(+) LDCs, possibly through their potent capacity to produce IgA-inducing cytokines...
  4. pmc Liganded thyroid hormone receptor inhibits phorbol 12-O-tetradecanoate-13-acetate-induced enhancer activity via firefly luciferase cDNA
    Hiroko Misawa
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    PLoS ONE 7:e28916. 2012
    ..Our data demonstrate that FFL cDNA sequence mediates the TPA-induced transcriptional activity, which is inhibited by T3/TR...
  5. ncbi request reprint Functions of PIT1 in GATA2-dependent transactivation of the thyrotropin beta promoter
    Yumiko Kashiwabara
    Department of Internal Medicine, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan
    J Mol Endocrinol 42:225-37. 2009
    ..Our study indicates that major activator for the TSHbeta promoter is GATA2 and that PIT1 protects the function of GATA2 from the inhibition by SR-binding protein...
  6. pmc Serum indoleamine 2,3-dioxygenase activity predicts prognosis of pulmonary tuberculosis
    Yuzo Suzuki
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Clin Vaccine Immunol 19:436-42. 2012
    ..850), and this activity was an independent prognostic factor in multivariate analysis. These results suggest that serum IDO activity can be used as a novel prognostic marker in PTB...
  7. doi request reprint Mouse lung CD103+ and CD11bhigh dendritic cells preferentially induce distinct CD4+ T-cell responses
    Kazuki Furuhashi
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Respir Cell Mol Biol 46:165-72. 2012
    ..These data suggest that mouse CD103(+) LDCs predominantly elicit Th1 and Th17 responses, whereas CD11b(high) LDCs primarily provoke a Th2 response under the steady state...
  8. doi request reprint Serum activity of indoleamine 2,3-dioxygenase predicts prognosis of community-acquired pneumonia
    Yuzo Suzuki
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Infect 63:215-22. 2011
    ..METODS: This study subjects consisted of 129 consecutive patients with CAP and 64 healthy controls. The concentrations of Kyn and Trp were measured simultaneously by liquid chromatography/electrospray ionization tandem mass spectrometry...
  9. pmc Essential role of TEA domain transcription factors in the negative regulation of the MYH 7 gene by thyroid hormone and its receptors
    Hiroyuki Iwaki
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    PLoS ONE 9:e88610. 2014
    ..These results indicate that T3-bound TRs interfere with transactivation by TEADs via protein-protein interactions, resulting in the negative regulation of MYH7 promoter activity. ..
  10. doi request reprint Enhancement of protective immunity against intracellular bacteria using type-1 polarized dendritic cell (DC) vaccine
    Masato Kono
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Vaccine 30:2633-9. 2012
    ..monocytogenes. Type-1 polarized DCs are potential candidates for enhancing protective immunity in the design of effective vaccination strategies against intracellular bacteria...
  11. pmc GATA2 mediates thyrotropin-releasing hormone-induced transcriptional activation of the thyrotropin β gene
    Kenji Ohba
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    PLoS ONE 6:e18667. 2011
    ..These results indicate that GATA2 is the principal mediator of the TRH signaling pathway in TSHβ expression...
  12. doi request reprint Impact of add-on pranlukast in stable asthma; the additive effect on peripheral airway inflammation
    Hideki Yasui
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Respir Med 106:508-14. 2012
    ..Systemic therapy with oral leukotriene receptor antagonist, pranlukast, may have additive effects to improve asthma control...
  13. doi request reprint Possible relevance between prohormone convertase 2 expression and tumor growth in human adrenocorticotropin-producing pituitary adenoma
    Kazumi Iino
    Second Division, Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama Higashi ku, Hamamatsu 431 3192, Japan
    J Clin Endocrinol Metab 95:4003-11. 2010
    ..Methods for preoperative diagnosis of prohormone convertase 2 (PC2)-positive ACTH-producing pituitary adenomas (APPAs) have not been established. Also, their characteristics are not evident...
  14. ncbi request reprint Syndrome of inappropriate secretion of thyrotropin associated with thymoma-related peripheral nerve hyperexcitability
    Kenji Ohba
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu 431 3192, Japan
    Endocr J 58:597-602. 2011
    ..Interestingly, the SITSH state became less prominent as his neurological manifestations improved. This is the first case of SITSH possibly caused by thymoma-associated PNH...
  15. ncbi request reprint Neuropeptide W stimulates adrenocorticotrophic hormone release via corticotrophin-releasing factor but not via arginine vasopressin
    Kosuke Yogo
    Second Division, Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu 431 3192, Japan
    Endocr J 59:547-54. 2012
    ..05). In conclusion, we suggest that central NPW activates the HPA axis by activating hypothalamic CRF but not AVP...
  16. ncbi request reprint Factors associated with fluorine-18-fluorodeoxyglucose uptake in benign thyroid nodules
    Kenji Ohba
    Department of Internal Medicine 2, Hamamatsu University School of Medicine, Hamamatsu 431 3192, Japan
    Endocr J 60:985-90. 2013
    ....
  17. doi request reprint Inappropriate elevation of serum thyrotropin levels in patients treated with axitinib
    Kenji Ohba
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Thyroid 23:443-8. 2013
    ..Although anticancer treatment with the tyrosine kinase inhibitor (TKI) axitinib frequently causes thyroid dysfunction, the associated mechanism and clinical features have not been elucidated...
  18. ncbi request reprint High incidence of thyroid cancer in focal thyroid incidentaloma detected by 18F-fluorodeoxyglucose [corrected] positron emission tomography in relatively young healthy subjects: results of 3-year follow-up
    Kenji Ohba
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Endocr J 57:395-401. 2010
    ..When closely examined, focal thyroid PET incidentaloma in relatively young healthy adults has a high probability of malignancy. Repeated FDG-PET to follow up patients with thyroid nodules is ineffective...
  19. doi request reprint Plasma CCN2 (connective tissue growth factor; CTGF) is a potential biomarker in idiopathic pulmonary fibrosis (IPF)
    Masato Kono
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Clin Chim Acta 412:2211-5. 2011
    ..Recently, we developed a new subtraction method for determination of plasma CCN2 levels. We examined the utility of plasma CCN2 levels as a surrogate marker in IPF...
  20. ncbi request reprint Falsely elevated thyroid hormone levels caused by anti-ruthenium interference in the Elecsys assay resembling the syndrome of inappropriate secretion of thyrotropin
    Kenji Ohba
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Japan
    Endocr J 59:663-7. 2012
    ..This type of interference should be considered when thyroid function is measured using the Elecsys technique, although the frequency of such findings is likely very low...
  21. pmc A cross-sectional study of glucose regulation in young adults with very low birth weight: impact of male gender on hyperglycaemia
    Ryosuke Sato
    Department of Endocrinology and Metabolism, Division of Internal Medicine II, Hamamatsu University School of Medicine, Hamamatsu, Japan
    BMJ Open 2:e000327. 2012
    ..To investigate glucose regulation in young adults with very low birth weight (VLBW; <1500 g) in an Asian population...
  22. doi request reprint Enhanced anti-tumor immunity by superantigen-pulsed dendritic cells
    Masato Kato
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Japan
    Cancer Immunol Immunother 60:1029-38. 2011
    ..Superantigens are potential candidates for enhancing tumor immunity in DC vaccines...
  23. doi request reprint Expressions of multidrug resistance protein 1 and multidrug resistance-associated protein 1 in lung dendritic cells
    Hirotsugu Hasegawa
    The Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Life Sci 89:282-7. 2011
    ..Interestingly, they are expressed in immune cells including some kinds of dendritic cells (DCs). In the present study, the expressions and activities of MDR1 and MRP1 in mouse lung DCs (LDCs) were investigated...
  24. doi request reprint The role of the amino-terminal domain in the interaction of unliganded peroxisome proliferator-activated receptor gamma-2 with nuclear receptor co-repressor
    Sadako Suzuki
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashi ku, Hamamatsu, Shizuoka 431 3192, Japan
    J Mol Endocrinol 45:133-45. 2010
    ..Inter-domain communication in PPARG2 regulates not only ligand-dependent transactivation but also ligand-independent silencing...
  25. doi request reprint A sudden onset and the spontaneous remission of severe hypo-high-density lipoprotein cholesterolemia without serious underlying disease: a case report
    Kenji Ohba
    Departments of Internal Medicine 2, Hamamatsu University School of Medicine, Hamamatsu, Japan Electronic address
    Clin Chim Acta 426:91-4. 2013
    ..Severe hypo-high-density lipoprotein (HDL) cholesterolemia is defined by serum values less than 20mg/dl. Few acquired cases, without serious underlying disease, have been reported...
  26. doi request reprint Antiendothelial Cell Antibodies in Patients With COPD
    Masato Karayama
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Chest 138:1303-8. 2010
    ..Recently, autoimmune mechanisms and vascular involvement have attracted attention in COPD. This study aimed to investigate the expression of AECA in patients with COPD...
  27. doi request reprint Increased expression of YKL-40, a chitinase-like protein, in serum and lung of patients with idiopathic pulmonary fibrosis
    Kazuki Furuhashi
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama Higashiku, Hamamatsu, Shizuoka 431 3192, Japan
    Respir Med 104:1204-10. 2010
    ..The present study was conducted to investigate YKL-40 expression in the serum and lung of IPF patients, and to determine its clinical significance...
  28. ncbi request reprint Significant correlation between visceral adiposity and high-sensitivity C-reactive protein (hs-CRP) in Japanese subjects
    Daisuke Tsuriya
    The Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Japan
    Intern Med 50:2767-73. 2011
    ....
  29. ncbi request reprint Future perspective on pharmacogenomics of severe hypoglycemia associated with sulfonylureas: reply from the authors
    Ryosuke Sato
    Department of Endocrinology and Metabolism, Division of Internal Medicine II, Hamamatsu University School of Medicine, Hamamatsu, Japan and Department of Endocrinology and Metabolism, Seirei Hamamatsu General Hospital, Hamamatsu, Japan
    Pharmacogenomics 13:9-10. 2012
    ..The Ser1369Ala variant of ABCC8 and the risk for severe sulfonylurea-induced hypoglycemia in German patients with Type 2 diabetes. Pharmacogenomics 13(1), 5-7 (2012)...
  30. doi request reprint Evaluation of different perfusion durations in direct hemoperfusion with polymyxin B-immobilized fiber column therapy for acute exacerbation of interstitial pneumonias
    Masato Kono
    Second Division, Department of Internal Medicine, Hamamatsu, Japan
    Blood Purif 32:75-81. 2011
    ..We examined the appropriate perfusion duration of PMX-DHP for AE-IP...
  31. doi request reprint ABCC8 polymorphism (Ser1369Ala): influence on severe hypoglycemia due to sulfonylureas
    Ryosuke Sato
    Department of Endocrinology and Metabolism, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Pharmacogenomics 11:1743-50. 2010
    ..However, the hypoglycemic effect of the Ser1369Ala variant on treatment with A + B binding site sulfonylureas, such as glimepiride or glibenclamide, is still uncertain...
  32. doi request reprint Nonspecific interstitial pneumonia: prognostic significance of high-resolution computed tomography in 59 patients
    Hironao Hozumi
    The Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Handayama Higashiku, Hamamatsu, Japan
    J Comput Assist Tomogr 35:583-9. 2011
    ..To retrospectively analyze the prognostic implications of high-resolution computed tomography (HRCT) findings for patients with biopsy-proven nonspecific interstitial pneumonia (NSIP)...
  33. ncbi request reprint Possible contribution of 2-aminoethoxydiphenyl-borate-sensitive Ca2+ mobilization to adrenocorticotropin-induced glucocorticoid synthesis in rat adrenocortical cells
    Chiga Hayashi
    Second Division, Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashi ku, Hamamatsu, Japan
    Endocr J 57:109-17. 2010
    ..We suggest that ACTH receptors activate steroidogenesis via inositol triphosphate, or an unknown downstream messenger, which could be inhibited by 2APB...
  34. doi request reprint A novel vaccine strategy to induce mycobacterial antigen-specific Th1 responses by utilizing the C-terminal domain of heat shock protein 70
    Tomohiro Uto
    Department of Infectious Diseases, Hamamatsu University School of Medicine, Hamamatsu, Japan
    FEMS Immunol Med Microbiol 61:189-96. 2011
    ....
  35. doi request reprint Effect of thyroid hormone on the activity of CYP3A enzyme in humans
    Norio Takahashi
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Clin Pharmacol 50:88-93. 2010
    ..92 to 5.88 (P < .05). These results strongly suggested that thyroid hormone reduced CYP3A activity in human and may influence the pharmacokinetics of concomitant CYP3A substrate drugs...
  36. ncbi request reprint Investigation into the efficacy and safety of octreotide LAR in Japanese patients with acromegaly: Shizuoka study
    Yutaka Oki
    Second Division, Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Endocr J 56:1095-101. 2009
    ..In conclusion, our results showed that OCT-LAR was safe and effective as a therapeutic option for Japanese patients with acromegaly in a postoperative setting, by controlling the disease activity...
  37. doi request reprint Increased serum kynurenine/tryptophan ratio correlates with disease progression in lung cancer
    Yuzo Suzuki
    Department of Internal Medicine, Hamamatsu University School of Medicine, 1 20 1 Hanadayama Higashiku, Hamamatsu, Shizuoka 431 3125, Japan
    Lung Cancer 67:361-5. 2010
    ..Thus, the present study investigated IDO activity determined by serum Trp and Kyn concentrations in lung cancer and the correlation between the IDO activity and clinical parameters...
  38. doi request reprint Inhibition of GATA2-dependent transactivation of the TSHbeta gene by ligand-bound estrogen receptor alpha
    Koji Nagayama
    Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431 3192, Japan
    J Endocrinol 199:113-25. 2008
    ..90 microU/ml+/-0.13 S.E.M. vs 1.47 microU/ml+/-0.12 S.E.M., P<0.05). Our findings indicate redundancy between T(3)-TR and E(2)-ERalpha signaling exists in negative regulation of the TSHbeta gene...
  39. ncbi request reprint A novel thyrotropin receptor germline mutation (Asp617Tyr) causing hereditary hyperthyroidism
    Eijun Nishihara
    Kuma Hospital, Kobe, Japan
    Endocr J 54:927-34. 2007
    ..Treatment with inorganic iodine for 7 months successfully relieved all symptoms of hyperthyroidism in both patients...
  40. ncbi request reprint Serum concentrations of granulocyte colony-stimulating factor (G-CSF) in antithyroid drug-induced agranulocytosis
    Yasuhiro Murakami
    Comprehensive Medical Center for Health, Otemae Hospital, Osaka 584 0008, Japan
    Endocr J 51:579-85. 2004
    ....
  41. doi request reprint The prevalence of transient thyrotoxicosis after antithyroid drug therapy in patients with Graves' disease
    Sumihisa Kubota
    Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    Thyroid 18:63-6. 2008
    ..When patients with transient hyperthyroidism are mistakenly regarded as recurrences, they receive unnecessary therapy. The aim of this study was to investigate the prevalence of transient thyrotoxicosis after ATD withdrawal...
  42. ncbi request reprint The relationship of psychological factors to the prognosis of hyperthyroidism in antithyroid drug-treated patients with Graves' disease
    Atsushi Fukao
    First Department of Internal Medicine, Osaka Medical College, Takatsuki City, Japan
    Clin Endocrinol (Oxf) 58:550-5. 2003
    ..This study has examined not only emotional stresses but also patients' personality traits using specific tests...
  43. ncbi request reprint Ratio of serum free triiodothyronine to free thyroxine in Graves' hyperthyroidism and thyrotoxicosis caused by painless thyroiditis
    Jaeduk Yoshimura Noh
    Ito Hospital, Tokyo, Japan
    Endocr J 52:537-42. 2005
    ..In conclusion, the FT3/FT4 ratios of patients with painless thyroiditis overlapped with those of patients with Graves' disease. However, this ratio was useful for differentiating between these two disorders when the FT4 values were high...
  44. ncbi request reprint Successful use of iodine and levothyroxine to treat Graves' disease in a pregnant patient with allergy to antithyroid drugs and high thyrotropin-binding inhibitor immunoglobulin after radioiodine therapy
    Sumihisa Kubota
    Kuma Hospital, Kobe, Japan
    Thyroid 15:1373-6. 2005
    ..Administration of iodine and LT(4) to a pregnant patient with Graves' disease showing a high TBII after ablative therapy should be considered in rare patients with allergy to ATD...
  45. ncbi request reprint Transient hyperthyroidism after withdrawal of antithyroid drugs in patients with Graves' disease
    Sumihisa Kubota
    Kuma Hospital, Kobe, Japan
    Endocr J 51:213-7. 2004
    ....
  46. ncbi request reprint Two-day thionamide withdrawal prior to radioiodine uptake sufficiently increases uptake and does not exacerbate hyperthyroidism compared to 7-day withdrawal in Graves' disease
    Sumihisa Kubota
    Kuma Hospital
    Endocr J 53:603-7. 2006
    ..We believe that the 2-day ATD withdrawal method may be useful for patients undergoing treatment with ATD who are to undergo radioiodine therapy...
  47. ncbi request reprint Four cases of Graves' disease which developed after painful Hashimoto's thyroiditis
    Hidemi Ohye
    Department of Internal Medicine, Kuma Hospital, Kobe
    Intern Med 45:385-9. 2006
    ..Thyroid damage due to painful Hashimoto's thyroiditis may be associated with the development of Graves' disease...
  48. ncbi request reprint Disturbed metabolism of remnant lipoproteins in patients with subclinical hypothyroidism
    Mitsuru Ito
    First Department of Medicine, Osaka Medical College, Takatsuki City, Osaka, Japan
    Am J Med 117:696-9. 2004
  49. ncbi request reprint Serial changes in liver function tests in patients with thyrotoxicosis induced by Graves' disease and painless thyroiditis
    Sumihisa Kubota
    Kuma Hospital, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    Thyroid 18:283-7. 2008
    ..However, a question arises whether such aggravation constitutes an adverse effect of the drugs or not...
  50. ncbi request reprint A case of hypothyroid Graves' disease following external radiation therapy to the cervical region
    Eijun Nishihara
    Kuma Hospital, Kobe, Japan
    Endocr J 53:357-61. 2006
    ..These results suggest that radiation-associated thyroidal injury might be associated with the etiology of hypothyroid Graves' disease...
  51. ncbi request reprint Effect of high dose methylprednisolone pulse therapy followed by oral prednisolone administration on the production of anti-TSH receptor antibodies and clinical outcome in Graves' disease
    Sumihisa Kubota
    Kuma Hospital, Kobe, Japan
    Endocr J 52:735-41. 2005
    ..57%. There was no significant difference between the two. These results suggest that the immunosuppressive effect of pulse therapy was temporary, and that pulse therapy did not increase remission rate of Graves' disease...
  52. ncbi request reprint Expression of thioredoxin in patients with Graves' disease
    Minoru Kihara
    Second Department of Surgery, Kagawa University Faculty of Medicine, Kita gun, Kagawa 761 0793, Japan
    Int J Mol Med 15:795-9. 2005
    ..The investigation of biological behavior of this molecule may greatly help to understand pathogenesis of Graves' disease functions...
  53. ncbi request reprint Intrathyroidal CD4+ T lymphocytes express high levels of Fas and CD4+ CD8+ macrophages/dendritic cells express Fas ligand in autoimmune thyroid disease
    Yukiyo Nakamura
    Division of Biomedical Informatics, Course of Health Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Thyroid 14:819-24. 2004
    ....
  54. ncbi request reprint High diagnostic value of a radioiodine uptake test with and without iodine restriction in Graves' disease and silent thyroiditis
    Tetsuya Hiraiwa
    First Department of Medicine, Osaka Medical College, Takatsuki City, Osaka, Japan
    Thyroid 14:531-5. 2004
    ..High diagnostic value of the RAIU test was confirmed, but not affected by the presence of iodine restriction in the differentiation between GD and ST, therefore, iodine restriction before the RAIU test was unnecessary...
  55. ncbi request reprint Increased intensities of fas expression on peripheral T-cell subsets in severe autoimmune thyroid disease
    Hayato Maruoka
    Division of Biomedical Informatics, Course of Health Sciences, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Thyroid 14:417-23. 2004
    ..the intensities of Fas expression on peripheral T cells increase in severe autoimmune thyroid diseases and (2). both the intensity and the proportion of Fas expression may be important for the induction of apoptosis...
  56. ncbi request reprint Increase of serum interleukin-10 in intractable Graves' disease
    Keiko Takeoka
    Division of Biomedical Informatics, Course of Health Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Thyroid 14:201-5. 2004
    ..However, the serum IL-10 concentration was not related to the severity of HD. These results indicate that IL-10, but not IL-4, is related to the intractability of GD, but not to the severity of HD...
  57. ncbi request reprint Changes in serum TSH receptor antibody (TRAb) values in patients with Graves' disease after total or subtotal thyroidectomy
    Yuuki Takamura
    Kuma Hospital, Kobe, Japan
    Endocr J 50:595-601. 2003
    ..TT is a treatment option for Graves' disease, especially in patients with a high TRAb value who wish to have children or who have Graves' opthalmopathy...
  58. ncbi request reprint Successful management of a patient with pseudomalabsorption of levothyroxine
    Sumihisa Kubota
    Kuma Hospital, Kobe, Japan
    Int J Psychiatry Med 33:183-8. 2003
    ..Our approach could be a therapeutic choice for this intractable disorder. To our knowledge, this is the first report of successful management of a patient with pseudomal-absorption of levothyroxine...
  59. ncbi request reprint Relation of CD30 molecules on T-cell subsets to the severity of autoimmune thyroid disease
    Mikio Watanabe
    Department of Clinical Laboratory Science, School of Allied Health Sciences, Osaka University, Suita, Osaka, Japan
    Thyroid 13:259-63. 2003
    ..These results indicate that CD30 molecules on CD4(+) and CD8(+) cells may be related to the severities of GD and HD, respectively...
  60. ncbi request reprint Thyroxine to triiodothyronine hyperconversion thyrotoxicosis in patients with large metastases of follicular thyroid carcinoma
    Toru Takano
    Department of Laboratory Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Thyroid 16:615-8. 2006
    ..In this report, we described the detail of these cases and examined the cause of T(3) thyrotoxicosis...
  61. ncbi request reprint Thyroid stimulation-blocking antibody and Graves' ophthalmopathy
    Sumihisa Kubota
    Thyroid 16:708. 2006
  62. ncbi request reprint Sporadic congenital hyperthyroidism due to a germline mutation in the thyrotropin receptor gene (Leu 512 Gln) in a Japanese patient
    Eijun Nishihara
    Kuma Hospital, Kobe, Japan
    Endocr J 53:735-40. 2006
    ..To our knowledge, this is the first report of a germline mutation of TSHR causing sporadic congenital nonautoimmune hyperthyroidism in a Japanese patient...
  63. doi request reprint Unusual finding on ultrasonography of follicular thyroid carcinoma including poorly differentiated thyroid carcinoma
    Minoru Kihara
    Thyroid 18:1021-2. 2008
  64. doi request reprint Graves' disease can be a lethal disorder in young adults
    Sumihisa Kubota
    Thyroid 18:915-6. 2008
  65. doi request reprint A novel homozygous missense mutation of the dual oxidase 2 (DUOX2) gene in an adult patient with large goiter
    Hidemi Ohye
    Department of Internal Medicine, Kuma Hospital, 8 2 35 Shimoyamate dori, Chuo Ku, Kobe, Japan
    Thyroid 18:561-6. 2008
    ..At the age of 56 years, goiter size remained the same. The perchlorate discharge rate was 72.8%, suggesting partial iodine organification defect. Thus, thyroid peroxidase (TPO) gene and DUOX2 gene were analyzed...
  66. doi request reprint 3,5,3'-Triiodothyronine thyrotoxicosis due to increased conversion of administered levothyroxine in patients with massive metastatic follicular thyroid carcinoma
    Akira Miyauchi
    Department of Surgery, Kuma Hospital, 8 2 35 Shimoyamate dori, Chuo Ku, Kobe, Japan
    J Clin Endocrinol Metab 93:2239-42. 2008
    ..Some patients with massive metastatic thyroid carcinoma exhibit T(3) thyrotoxicosis. We investigated the prevalence and cause of T(3) thyrotoxicosis and the clues to the diagnosis...
  67. ncbi request reprint Decrease of intrathyroidal CD161+Valpha24+Vbeta11+ NKT cells in Graves' disease
    Mikio Watanabe
    Department of Biomedical Informatics, Division of Health Science, Osaka University Graduate School of Medicine, Suita, Japan
    Endocr J 55:199-203. 2008
    ..These results indicate that the proportion of intrathyroidal NKT cells is decreased in patients with GD and that this decrease may contribute to incomplete regulation of autoreactive T cells in GD...
  68. ncbi request reprint Appropriate treatment for asymptomatic papillary microcarcinoma of the thyroid
    Yasuhiro Ito
    Kuma Hospital, Department of Surgery, 8 2 35, Shimoyamate dori, Chuo Ku, Kobe 650 0011, Japan
    Expert Opin Pharmacother 8:3205-15. 2007
    ..If surgical treatment is performed for low-risk PMC, prophylactic modified radical neck dissection is not necessary and lobectomy (with isthmectomy) and central node dissection is adequate if the tumor is located only in one lobe...
  69. ncbi request reprint Quantitative measurement of thyroid blood flow for differentiation of painless thyroiditis from Graves' disease
    Hisashi Ota
    Kuma Hospital, Kobe, Japan
    Clin Endocrinol (Oxf) 67:41-5. 2007
    ..It is, however, often difficult to make this distinction without measurement of radioactive iodine uptake. We investigated the possibility that assessment of thyroid blood flow would allow differentiation between the two entities...
  70. ncbi request reprint Quantitative measurement of anti-TSH receptor antibodies is useful for the evaluation of treatment effect
    Nobuyuki Amino
    Thyroid 17:85-6. 2007
  71. ncbi request reprint [Current status and the goal of surgical treatment for Graves' disease]
    Akihiro Miya
    Department of Surgery, Kuma Hospital
    Nihon Rinsho 64:2263-8. 2006
    ..Here, we analyze trend in our practice in Kuma Hospital, and explain change in our surgical goal, surgical procedures and results...
  72. ncbi request reprint Effect of levo-thyroxine replacement on non-high-density lipoprotein cholesterol in hypothyroid patients
    Mitsuru Ito
    Kuma Hospital, Kobe 650 0011, Japan
    J Clin Endocrinol Metab 92:608-11. 2007
    ..Recently, non-high-density lipoprotein cholesterol (non-HDL-C), a measure of total cholesterol minus HDL-C, has emerged as a predictor of cardiovascular disease...
  73. ncbi request reprint Serum concentrations of remnant-like particles in hypothyroid patients before and after thyroxine replacement
    Mitsuru Ito
    The Kuma Hospital, Kobe, Hyogo, Japan
    Clin Endocrinol (Oxf) 58:621-6. 2003
    ....