Research Topics
| T NagataSummaryAffiliation: Hamamatsu University School of Medicine Country: Japan Publications
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Detail Information
Publications
Identification of T cell epitopes of Mycobacterium tuberculosis with biolistic DNA vaccinationToshi Nagata
Department of Health Science, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
Methods Mol Biol 940:285-303. 2013..We have been using DNA vaccines with gene gun bombardment for T cell epitope identification of various Mtb antigens. We show here our strategy to identify precise Mtb T cell epitopes using DNA vaccines with gene gun bombardment...
Induction of protective immunity to Listeria monocytogenes by immunization with plasmid DNA expressing a helper T-cell epitope that replaces the class II-associated invariant chain peptide of the invariant chainToshi Nagata
Department of Microbiology and Immunology, Hamamatsu University School of Medicine, 1 20 1 Handa yama, Hamamatsu 431 3192, Japan
Infect Immun 70:2676-80. 2002..Immunization of C3H/He mice with an Ii-LLO 215-226 plasmid induced specific interferon-gamma- and interleukin 2-producing Th cells and conferred significant protective immunity against listerial infection...- In vivo hierarchy of individual T-cell epitope-specific helper T-cell subset against an intracellular bacteriumToshi Nagata
Department of Health Science, Hamamatsu University School of Medicine, 1 20 1 Higashi ku, Handa yama, Hamamatsu 431 3192, Japan
Vaccine 26:5123-7. 2008.... 
Cytotoxic T-lymphocyte-, and helper T-lymphocyte-oriented DNA vaccinationToshi Nagata
Department of Microbiology and Immunology, Hamamatsu University School of Medicine, Japan
DNA Cell Biol 23:93-106. 2004..From this review, it has been surmised that, to induce strong immune responses by DNA vaccines, the immunization route and the immunization regimen, such as heterologous "prime-boost" regimen, should also be considered...- Immunization with plasmid DNA encoding MHC class II binding peptide/CLIP-replaced invariant chain (Ii) induces specific helper T cells in vivo: the assessment of Ii p31 and p41 isoforms as vehicles for immunizationT Nagata
Department of Microbiology and Immunology, Hamamatsu University School of Medicine, 1 20 1 Handa yama, 431 3192, Hamamatsu, Japan
Vaccine 20:105-14. 2001..Some mice immunized with the Ii p41-OVA323, but not with the Ii p31-OVA323 plasmid, produced the peptide-specific antibodies, suggesting the functional difference between Ii isoforms... - Immunization with a gene encoding granulocyte-macrophage colony-stimulating factor inserted with a single helper T-cell epitope of an intracellular bacterium induces a specific T-cell subset and protective immunityToshi Nagata
Department of Microbiology and Immunology, Hamamatsu University School of Medicine, Hamamatsu 431 3192, Japan
Vaccine 24:4548-53. 2006..These results suggest that immunization of a gene for GM-CSF inserted with a Th epitope is useful for eliciting a specific Th subset in vivo... - Codon optimization effect on translational efficiency of DNA vaccine in mammalian cells: analysis of plasmid DNA encoding a CTL epitope derived from microorganismsT Nagata
Department of Microbiology and Immunology, Hamamatsu University School of Medicine, 3600 Handa Cho, Hamamatsu, 431 3192, Japan
Biochem Biophys Res Commun 261:445-51. 1999..These results suggest that DNA immunization using the gene codon-optimized to mammals through the entire region is very effective... - Protective CTL response is induced in the absence of CD4+ T cells and IFN-gamma by gene gun DNA vaccination with a minigene encoding a CTL epitope of Listeria monocytogenesA Yoshida
Department of Microbiology and Immunology, Hamamatsu University School of Medicine, 431-3192, Hamamatsu, Japan
Vaccine 19:4297-306. 2001..The CTL induction is also suggested to require neither adjuvant activity of the plasmid used nor IFN-gamma. The data may be feasible for the design of CTL inducing vaccines in various immunodeficiencies... - Toxic shock syndrome toxin-1 accelerated collagen-induced arthritis in miceY Kageyama
Department of Orthopedic Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan
J Autoimmun 16:125-31. 2001..Our experiments demonstrated that CIA was aggravated by the treatment with TSST-1, which may have induced various proinflammatory cytokines and the production of both Th1 and Th2 cytokines... - Cytokine and antibody production during the course of resolution in Plasmodium yoelii 17XL-infected BALB/c mice treated with febrifugine and isofebrifugine mixture from leaves of Hydrangea macrophylla var. OtaksaA Ishih
Department of Parasitology, Hamamatsu University School of Medicine, 1 20 1 Handayama, 431 3192, Hamamatsu, Japan
Parasitol Res 94:176-82. 2004.... - Identification of immunostimulatory DNA-induced genes by suppression subtractive hybridizationM Uchijima
Department of Microbiology and Immunology, Hamamatsu University School of Medicine, 1 20 1 Handa yama, Hamamatsu 431 3192, Japan
Biochem Biophys Res Commun 286:688-91. 2001..These genes were suggested to be involved in the molecular process of innate host defense mechanisms... - Application of fuzzy inference to European patients to predict cervical lymph node metastasis in carcinoma of the tongueT Nagata
Department of Oral and Maxillofacial Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan
Int J Oral Maxillofac Surg 34:138-42. 2005..However, the current level sensitivity is inadequate for routine clinical use. Therefore, other predictors of lymph node metastasis should be identified to refine the current model... - Patency assessment of the internal jugular vein after neck dissectionT Nagata
Department of Oral and Maxillofacial Surgery, Hamamatsu University School of Medicine, 1 20 1, Handa yama, Hamamatsu City, Shizuoka, 431 3125 Hamamatsu, Japan
Int J Oral Maxillofac Surg 35:416-20. 2006..7% of the patients, and 'narrowing' was present in 63.6%. The size of the flap significantly correlated with 'narrowing' of the IJV, suggesting that 'narrowing' was caused mainly by compression due to the flap... - Immunogenicity of dormancy-related antigens in individuals infected with Mycobacterium tuberculosis in JapanH Hozumi
Department of Infectious Diseases, and Internal Medicine 2 Divisions of Endocrinology and Metabolism, Respiratology and Hepatology, Hamamatsu University School of Medicine, Hamamatsu, Japan
Int J Tuberc Lung Dis 17:818-24. 2013..tuberculosis-infected individuals, suggesting that DosR regulon-encoded proteins are suitable targets for vaccines to control the reactivation of dormant M. tuberculosis... - Intestinal granuloma formation in normal and SCID BALB/c mice infected with Angiostrongylus costaricensisA Ishih
Department of Parasitology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
Parasitol Res 89:150-3. 2003..These results suggest that Th1-mediated immunity is required for granuloma formation in response to A. costaricensis infection in mice... - Protective cytotoxic T lymphocyte responses induced by DNA immunization against immunodominant and subdominant epitopes of Listeria monocytogenes are noncompetitiveT Yamada
Second Department of Internal Medicine, Hamamatsu Univeristy School of Medicine, Hamamatsu 431-3192, Japan
Infect Immun 69:3427-30. 2001..Furthermore, we found that a single dominant epitope is sufficient for the induction of protective immunity... - Comparison of fuzzy inference, logistic regression, and classification trees (CART). Prediction of cervical lymph node metastasis in carcinoma of the tongueG Schwarzer
Institute of Medical Biometry and Medical Informatics, University of Freiburg, Germany
Methods Inf Med 42:572-7. 2003..In this paper three statistical methods [logistic regression, classification and regression tree (CART), and fuzzy inference] for the prediction of lymph node metastasis in carcinoma of the tongue are compared... - A novel melon flexivirus transmitted by whiteflyT Nagata
Pos Graduacao em Ciencias Genomicas e Biotecnologia, Universidade Catolica de Brasilia, W5 Norte, 70790 160 Brasília, DF, Brazil
Arch Virol 150:379-87. 2005..The name Melon yellowing-associated virus (MYaV) is tentatively suggested for this virus... - Induction of calprotectin release by Porphyromonas gingivalis lipopolysaccharide in human neutrophilsJ Kido
Department of Periodontology and Endodontology, Tokushima University School of Dentistry, Tokushima, Japan
Oral Microbiol Immunol 19:182-7. 2004..intermedia, F. nucleatum, and E. coli also induced calprotectin release from neutrophils. These results suggest that lipopolysaccharides from periodontopathic bacteria induce calprotectin release from human neutrophils... - Differing effects of clarithromycin and azithromycin on cytokine production by murine dendritic cellsK Sugiyama
Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
Clin Exp Immunol 147:540-6. 2007..These findings suggest that 14-membered and 15-membered, but not 16-membered macrolides play as anti-inflammatory agents, at least in part, through modulating the functions of DCs. However, each macrolide affects them in different ways... - Molecular diversity of ecologically distinct Mal de Río Cuarto virus isolates based on restriction fragment length polymorphism (RFLPs) and genome sequence analysis of segments 1, 7, 9 and 10M P Giménez Pecci
Instituto de Fitopatología y Fisiología Vegetal, Instituto Nacional de Tecnologia Agropecuaria INTA, Cordoba, Argentina
Arch Virol 152:1341-51. 2007..Phylogeny analysis showed that MRCV isolates could be clustered in 'mountain area' and 'high production area' groups according to their geographical occurrence... - Brugmansia suaveolens mottle virus, a novel potyvirus causing leaf mottling of Brugmansia suaveolens in BrazilN Lucinda
Departamento de Ciencias Biologicas, Universidade Catolica de Brasilia, Brasilia, DF, Brazil
Arch Virol 153:1971-6. 2008..Since this identity value is below the threshold currently used to discriminate Potyvirus species, Brugmansia suaveolens mottle virus most likely represents a new Potyvirus species... - High serum concentrations of surfactant protein A in usual interstitial pneumonia compared with non-specific interstitial pneumoniaH Ishii
Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
Thorax 58:52-7. 2003..01, mean difference 322.4 ng/ml, 95% confidence interval 79.3 to 565.5). CONCLUSION: Serum SP-A levels may be clinically useful as a biomarker to differentiate between UIP and NSIP... - Overexpression of pyrimidine nucleoside phosphorylase enhances the sensitivity to 5'-deoxy-5-fluorouridine in tumour cells in vitro and in vivoT Nagata
Second Department of Surgery, Wakayama Medical School, Kimiidera, Japan
Eur J Cancer 38:712-7. 2002..These findings demonstrate that PyNPase gene transfection increases the sensitivity to 5'-DFUR, and thereby decreases the toxicity of the agent... - Genetic analyses of an amber mutation in Escherichia coli K-12, affecting deoxyribonucleic acid ligase and viabilityT Sato
J Bacteriol 124:1089-96. 1975..The lig-4 and lig-ts7 alleles are known to reside in the structural gene for DNA ligase, in which lig-321 may also be located... - H-2RIIBP (RXR beta) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genesM S Marks
Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
EMBO J 11:1419-35. 1992..The results suggest that H-2RIIBP, by virtue of its ability to heterodimerize, enhances combinatorial diversity and versatility in gene regulation mediated by nuclear hormone receptors... - Structural analysis of the dnaA and dnaN genes of Escherichia coliH Ohmori
Gene 28:159-70. 1984..Examination of the intercistronic sequence and analysis of in vitro transcription supported the notion that the dnaA and dnaN genes constitute a single operon... - The pcsA gene is identical to dinD in Escherichia coliH Ohmori
Institute for Virus Research, Kyoto University, Japan
J Bacteriol 177:156-65. 1995..We discuss the possible function of the pcsA gene, comparing it with the sulA or the dif-xerCD function. We also describe a new method for gene disruption with positive and negative selection... - The mouse Rxrb gene encoding RXR beta: genomic organization and two mRNA isoforms generated by alternative splicing of transcripts initiated from CpG island promotersT Nagata
Banyu Tsukuba Research Institute Merck, Japan
Gene 142:183-9. 1994..These results, together with their unique ability to form heterodimers with other members of the superfamily, suggest a distinct phylogenic position for the Rxr genes... - Cell cycle-dependent accumulation of a kinesin-like protein, KatB/C in synchronized tobacco BY-2 cellsH Mitsui
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
Plant Mol Biol 30:177-81. 1996..Microtubule-based structures present in cells at M phase, such as the spindle and phragmoplast, may be the site of action of the KatB/C protein... - Multicopy suppressors of the cold-sensitive phenotype of the pcsA68 (dinD68) mutation in Escherichia coliT Yasuda
Institute for Virus Research, Kyoto University, Japan
J Bacteriol 178:3854-9. 1996..It is similar in size and sequence to ImpC of the Salmonella typhimurium plasmid TP110 and to a protein (ORFfs) of the retronphage phi R67, both of which are also under the control of LexA... - Structural properties and RNA-binding activities of two RNA recognition motifs of a mouse neural RNA-binding protein, mouse-Musashi-1Y Kurihara
Department of Bioengineering, Faculty of Engineering, Yokohama National University, Japan
Gene 186:21-7. 1997.... - IFN-gamma induces expression of MHC class I molecules in adult mouse dorsal root ganglion neuronesH Fujimaki
Department of Immunology and Parasitology, School of Medicine, Yokohama City University, Japan
Neuroreport 7:2951-5. 1996..These results indicated that DRG neurones are able to express MHC class I molecules following IFN-gamma treatment and suggest that DRG neurones themselves are susceptible to recognition by cytotoxic T cells... - [Cytotoxic activity and cytokine gene induction of Asp-hemolysin to vascular endothelial cells]T Kumagai
First Department of Hygienic Chemistry, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan
Yakugaku Zasshi 121:271-5. 2001.... - A role of ghrelin in neuroendocrine and behavioral responses to stress in miceA Asakawa
Second Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
Neuroendocrinology 74:143-7. 2001.... - The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn-finger protein aprataxinM C Moreira
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Illkirch, C U de Strasbourg, France
Nat Genet 29:189-93. 2001.... - Cloning and physical mapping of the dnaA region of the Escherichia coli chromosomeT Miki
J Bacteriol 140:817-24. 1979..29 Md, containing the 3.5-Md dnaA substitution segment, from the lambda i21 dnaA-2 DNA, inserting it into the sole BamHI cleavage site on pBR322...