T Nagata

Summary

Affiliation: Hamamatsu University School of Medicine
Country: Japan

Publications

  1. doi request reprint Identification of T cell epitopes of Mycobacterium tuberculosis with biolistic DNA vaccination
    Toshi Nagata
    Department of Health Science, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Methods Mol Biol 940:285-303. 2013
  2. pmc Induction of protective immunity to Listeria monocytogenes by immunization with plasmid DNA expressing a helper T-cell epitope that replaces the class II-associated invariant chain peptide of the invariant chain
    Toshi Nagata
    Department of Microbiology and Immunology, Hamamatsu University School of Medicine, 1 20 1 Handa yama, Hamamatsu 431 3192, Japan
    Infect Immun 70:2676-80. 2002
  3. doi request reprint In vivo hierarchy of individual T-cell epitope-specific helper T-cell subset against an intracellular bacterium
    Toshi Nagata
    Department of Health Science, Hamamatsu University School of Medicine, 1 20 1 Higashi ku, Handa yama, Hamamatsu 431 3192, Japan
    Vaccine 26:5123-7. 2008
  4. ncbi request reprint Cytotoxic T-lymphocyte-, and helper T-lymphocyte-oriented DNA vaccination
    Toshi Nagata
    Department of Microbiology and Immunology, Hamamatsu University School of Medicine, Japan
    DNA Cell Biol 23:93-106. 2004
  5. ncbi request reprint Immunization with plasmid DNA encoding MHC class II binding peptide/CLIP-replaced invariant chain (Ii) induces specific helper T cells in vivo: the assessment of Ii p31 and p41 isoforms as vehicles for immunization
    T Nagata
    Department of Microbiology and Immunology, Hamamatsu University School of Medicine, 1 20 1 Handa yama, 431 3192, Hamamatsu, Japan
    Vaccine 20:105-14. 2001
  6. ncbi request reprint Immunization with a gene encoding granulocyte-macrophage colony-stimulating factor inserted with a single helper T-cell epitope of an intracellular bacterium induces a specific T-cell subset and protective immunity
    Toshi Nagata
    Department of Microbiology and Immunology, Hamamatsu University School of Medicine, Hamamatsu 431 3192, Japan
    Vaccine 24:4548-53. 2006
  7. ncbi request reprint Codon optimization effect on translational efficiency of DNA vaccine in mammalian cells: analysis of plasmid DNA encoding a CTL epitope derived from microorganisms
    T Nagata
    Department of Microbiology and Immunology, Hamamatsu University School of Medicine, 3600 Handa Cho, Hamamatsu, 431 3192, Japan
    Biochem Biophys Res Commun 261:445-51. 1999
  8. ncbi request reprint Protective CTL response is induced in the absence of CD4+ T cells and IFN-gamma by gene gun DNA vaccination with a minigene encoding a CTL epitope of Listeria monocytogenes
    A Yoshida
    Department of Microbiology and Immunology, Hamamatsu University School of Medicine, 431-3192, Hamamatsu, Japan
    Vaccine 19:4297-306. 2001
  9. ncbi request reprint Toxic shock syndrome toxin-1 accelerated collagen-induced arthritis in mice
    Y Kageyama
    Department of Orthopedic Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Autoimmun 16:125-31. 2001
  10. ncbi request reprint Cytokine and antibody production during the course of resolution in Plasmodium yoelii 17XL-infected BALB/c mice treated with febrifugine and isofebrifugine mixture from leaves of Hydrangea macrophylla var. Otaksa
    A Ishih
    Department of Parasitology, Hamamatsu University School of Medicine, 1 20 1 Handayama, 431 3192, Hamamatsu, Japan
    Parasitol Res 94:176-82. 2004

Collaborators

Detail Information

Publications37

  1. doi request reprint Identification of T cell epitopes of Mycobacterium tuberculosis with biolistic DNA vaccination
    Toshi Nagata
    Department of Health Science, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Methods Mol Biol 940:285-303. 2013
    ..We have been using DNA vaccines with gene gun bombardment for T cell epitope identification of various Mtb antigens. We show here our strategy to identify precise Mtb T cell epitopes using DNA vaccines with gene gun bombardment...
  2. pmc Induction of protective immunity to Listeria monocytogenes by immunization with plasmid DNA expressing a helper T-cell epitope that replaces the class II-associated invariant chain peptide of the invariant chain
    Toshi Nagata
    Department of Microbiology and Immunology, Hamamatsu University School of Medicine, 1 20 1 Handa yama, Hamamatsu 431 3192, Japan
    Infect Immun 70:2676-80. 2002
    ..Immunization of C3H/He mice with an Ii-LLO 215-226 plasmid induced specific interferon-gamma- and interleukin 2-producing Th cells and conferred significant protective immunity against listerial infection...
  3. doi request reprint In vivo hierarchy of individual T-cell epitope-specific helper T-cell subset against an intracellular bacterium
    Toshi Nagata
    Department of Health Science, Hamamatsu University School of Medicine, 1 20 1 Higashi ku, Handa yama, Hamamatsu 431 3192, Japan
    Vaccine 26:5123-7. 2008
    ....
  4. ncbi request reprint Cytotoxic T-lymphocyte-, and helper T-lymphocyte-oriented DNA vaccination
    Toshi Nagata
    Department of Microbiology and Immunology, Hamamatsu University School of Medicine, Japan
    DNA Cell Biol 23:93-106. 2004
    ..From this review, it has been surmised that, to induce strong immune responses by DNA vaccines, the immunization route and the immunization regimen, such as heterologous "prime-boost" regimen, should also be considered...
  5. ncbi request reprint Immunization with plasmid DNA encoding MHC class II binding peptide/CLIP-replaced invariant chain (Ii) induces specific helper T cells in vivo: the assessment of Ii p31 and p41 isoforms as vehicles for immunization
    T Nagata
    Department of Microbiology and Immunology, Hamamatsu University School of Medicine, 1 20 1 Handa yama, 431 3192, Hamamatsu, Japan
    Vaccine 20:105-14. 2001
    ..Some mice immunized with the Ii p41-OVA323, but not with the Ii p31-OVA323 plasmid, produced the peptide-specific antibodies, suggesting the functional difference between Ii isoforms...
  6. ncbi request reprint Immunization with a gene encoding granulocyte-macrophage colony-stimulating factor inserted with a single helper T-cell epitope of an intracellular bacterium induces a specific T-cell subset and protective immunity
    Toshi Nagata
    Department of Microbiology and Immunology, Hamamatsu University School of Medicine, Hamamatsu 431 3192, Japan
    Vaccine 24:4548-53. 2006
    ..These results suggest that immunization of a gene for GM-CSF inserted with a Th epitope is useful for eliciting a specific Th subset in vivo...
  7. ncbi request reprint Codon optimization effect on translational efficiency of DNA vaccine in mammalian cells: analysis of plasmid DNA encoding a CTL epitope derived from microorganisms
    T Nagata
    Department of Microbiology and Immunology, Hamamatsu University School of Medicine, 3600 Handa Cho, Hamamatsu, 431 3192, Japan
    Biochem Biophys Res Commun 261:445-51. 1999
    ..These results suggest that DNA immunization using the gene codon-optimized to mammals through the entire region is very effective...
  8. ncbi request reprint Protective CTL response is induced in the absence of CD4+ T cells and IFN-gamma by gene gun DNA vaccination with a minigene encoding a CTL epitope of Listeria monocytogenes
    A Yoshida
    Department of Microbiology and Immunology, Hamamatsu University School of Medicine, 431-3192, Hamamatsu, Japan
    Vaccine 19:4297-306. 2001
    ..The CTL induction is also suggested to require neither adjuvant activity of the plasmid used nor IFN-gamma. The data may be feasible for the design of CTL inducing vaccines in various immunodeficiencies...
  9. ncbi request reprint Toxic shock syndrome toxin-1 accelerated collagen-induced arthritis in mice
    Y Kageyama
    Department of Orthopedic Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Autoimmun 16:125-31. 2001
    ..Our experiments demonstrated that CIA was aggravated by the treatment with TSST-1, which may have induced various proinflammatory cytokines and the production of both Th1 and Th2 cytokines...
  10. ncbi request reprint Cytokine and antibody production during the course of resolution in Plasmodium yoelii 17XL-infected BALB/c mice treated with febrifugine and isofebrifugine mixture from leaves of Hydrangea macrophylla var. Otaksa
    A Ishih
    Department of Parasitology, Hamamatsu University School of Medicine, 1 20 1 Handayama, 431 3192, Hamamatsu, Japan
    Parasitol Res 94:176-82. 2004
    ....
  11. ncbi request reprint Identification of immunostimulatory DNA-induced genes by suppression subtractive hybridization
    M Uchijima
    Department of Microbiology and Immunology, Hamamatsu University School of Medicine, 1 20 1 Handa yama, Hamamatsu 431 3192, Japan
    Biochem Biophys Res Commun 286:688-91. 2001
    ..These genes were suggested to be involved in the molecular process of innate host defense mechanisms...
  12. ncbi request reprint Application of fuzzy inference to European patients to predict cervical lymph node metastasis in carcinoma of the tongue
    T Nagata
    Department of Oral and Maxillofacial Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Int J Oral Maxillofac Surg 34:138-42. 2005
    ..However, the current level sensitivity is inadequate for routine clinical use. Therefore, other predictors of lymph node metastasis should be identified to refine the current model...
  13. ncbi request reprint Patency assessment of the internal jugular vein after neck dissection
    T Nagata
    Department of Oral and Maxillofacial Surgery, Hamamatsu University School of Medicine, 1 20 1, Handa yama, Hamamatsu City, Shizuoka, 431 3125 Hamamatsu, Japan
    Int J Oral Maxillofac Surg 35:416-20. 2006
    ..7% of the patients, and 'narrowing' was present in 63.6%. The size of the flap significantly correlated with 'narrowing' of the IJV, suggesting that 'narrowing' was caused mainly by compression due to the flap...
  14. doi request reprint Immunogenicity of dormancy-related antigens in individuals infected with Mycobacterium tuberculosis in Japan
    H Hozumi
    Department of Infectious Diseases, and Internal Medicine 2 Divisions of Endocrinology and Metabolism, Respiratology and Hepatology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Int J Tuberc Lung Dis 17:818-24. 2013
    ..tuberculosis-infected individuals, suggesting that DosR regulon-encoded proteins are suitable targets for vaccines to control the reactivation of dormant M. tuberculosis...
  15. ncbi request reprint Intestinal granuloma formation in normal and SCID BALB/c mice infected with Angiostrongylus costaricensis
    A Ishih
    Department of Parasitology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Parasitol Res 89:150-3. 2003
    ..These results suggest that Th1-mediated immunity is required for granuloma formation in response to A. costaricensis infection in mice...
  16. pmc Protective cytotoxic T lymphocyte responses induced by DNA immunization against immunodominant and subdominant epitopes of Listeria monocytogenes are noncompetitive
    T Yamada
    Second Department of Internal Medicine, Hamamatsu Univeristy School of Medicine, Hamamatsu 431-3192, Japan
    Infect Immun 69:3427-30. 2001
    ..Furthermore, we found that a single dominant epitope is sufficient for the induction of protective immunity...
  17. ncbi request reprint Comparison of fuzzy inference, logistic regression, and classification trees (CART). Prediction of cervical lymph node metastasis in carcinoma of the tongue
    G Schwarzer
    Institute of Medical Biometry and Medical Informatics, University of Freiburg, Germany
    Methods Inf Med 42:572-7. 2003
    ..In this paper three statistical methods [logistic regression, classification and regression tree (CART), and fuzzy inference] for the prediction of lymph node metastasis in carcinoma of the tongue are compared...
  18. ncbi request reprint A novel melon flexivirus transmitted by whitefly
    T Nagata
    Pos Graduacao em Ciencias Genomicas e Biotecnologia, Universidade Catolica de Brasilia, W5 Norte, 70790 160 Brasília, DF, Brazil
    Arch Virol 150:379-87. 2005
    ..The name Melon yellowing-associated virus (MYaV) is tentatively suggested for this virus...
  19. ncbi request reprint Induction of calprotectin release by Porphyromonas gingivalis lipopolysaccharide in human neutrophils
    J Kido
    Department of Periodontology and Endodontology, Tokushima University School of Dentistry, Tokushima, Japan
    Oral Microbiol Immunol 19:182-7. 2004
    ..intermedia, F. nucleatum, and E. coli also induced calprotectin release from neutrophils. These results suggest that lipopolysaccharides from periodontopathic bacteria induce calprotectin release from human neutrophils...
  20. pmc Differing effects of clarithromycin and azithromycin on cytokine production by murine dendritic cells
    K Sugiyama
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Clin Exp Immunol 147:540-6. 2007
    ..These findings suggest that 14-membered and 15-membered, but not 16-membered macrolides play as anti-inflammatory agents, at least in part, through modulating the functions of DCs. However, each macrolide affects them in different ways...
  21. ncbi request reprint Molecular diversity of ecologically distinct Mal de Río Cuarto virus isolates based on restriction fragment length polymorphism (RFLPs) and genome sequence analysis of segments 1, 7, 9 and 10
    M P Giménez-Pecci
    Instituto de Fitopatología y Fisiología Vegetal, Instituto Nacional de Tecnologia Agropecuaria INTA, Cordoba, Argentina
    Arch Virol 152:1341-51. 2007
    ..Phylogeny analysis showed that MRCV isolates could be clustered in 'mountain area' and 'high production area' groups according to their geographical occurrence...
  22. doi request reprint Brugmansia suaveolens mottle virus, a novel potyvirus causing leaf mottling of Brugmansia suaveolens in Brazil
    N Lucinda
    Departamento de Ciencias Biologicas, Universidade Catolica de Brasilia, Brasilia, DF, Brazil
    Arch Virol 153:1971-6. 2008
    ..Since this identity value is below the threshold currently used to discriminate Potyvirus species, Brugmansia suaveolens mottle virus most likely represents a new Potyvirus species...
  23. pmc High serum concentrations of surfactant protein A in usual interstitial pneumonia compared with non-specific interstitial pneumonia
    H Ishii
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Thorax 58:52-7. 2003
    ..Surfactant protein (SP)-A, SP-D, KL-6, sialyl SSEA-1 (SLX), and sialyl Lewis(a) (CA19-9) are useful markers for the diagnosis and evaluation of activity of ILD. We have investigated the usefulness of these proteins as markers of UIP...
  24. ncbi request reprint Overexpression of pyrimidine nucleoside phosphorylase enhances the sensitivity to 5'-deoxy-5-fluorouridine in tumour cells in vitro and in vivo
    T Nagata
    Second Department of Surgery, Wakayama Medical School, Kimiidera, Japan
    Eur J Cancer 38:712-7. 2002
    ..These findings demonstrate that PyNPase gene transfection increases the sensitivity to 5'-DFUR, and thereby decreases the toxicity of the agent...
  25. pmc Genetic analyses of an amber mutation in Escherichia coli K-12, affecting deoxyribonucleic acid ligase and viability
    T Sato
    J Bacteriol 124:1089-96. 1975
    ..The lig-4 and lig-ts7 alleles are known to reside in the structural gene for DNA ligase, in which lig-321 may also be located...
  26. pmc H-2RIIBP (RXR beta) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes
    M S Marks
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
    EMBO J 11:1419-35. 1992
    ..The results suggest that H-2RIIBP, by virtue of its ability to heterodimerize, enhances combinatorial diversity and versatility in gene regulation mediated by nuclear hormone receptors...
  27. ncbi request reprint Structural analysis of the dnaA and dnaN genes of Escherichia coli
    H Ohmori
    Gene 28:159-70. 1984
    ..Examination of the intercistronic sequence and analysis of in vitro transcription supported the notion that the dnaA and dnaN genes constitute a single operon...
  28. pmc The pcsA gene is identical to dinD in Escherichia coli
    H Ohmori
    Institute for Virus Research, Kyoto University, Japan
    J Bacteriol 177:156-65. 1995
    ..We discuss the possible function of the pcsA gene, comparing it with the sulA or the dif-xerCD function. We also describe a new method for gene disruption with positive and negative selection...
  29. ncbi request reprint The mouse Rxrb gene encoding RXR beta: genomic organization and two mRNA isoforms generated by alternative splicing of transcripts initiated from CpG island promoters
    T Nagata
    Banyu Tsukuba Research Institute Merck, Japan
    Gene 142:183-9. 1994
    ..These results, together with their unique ability to form heterodimers with other members of the superfamily, suggest a distinct phylogenic position for the Rxr genes...
  30. ncbi request reprint Cell cycle-dependent accumulation of a kinesin-like protein, KatB/C in synchronized tobacco BY-2 cells
    H Mitsui
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
    Plant Mol Biol 30:177-81. 1996
    ..Microtubule-based structures present in cells at M phase, such as the spindle and phragmoplast, may be the site of action of the KatB/C protein...
  31. pmc Multicopy suppressors of the cold-sensitive phenotype of the pcsA68 (dinD68) mutation in Escherichia coli
    T Yasuda
    Institute for Virus Research, Kyoto University, Japan
    J Bacteriol 178:3854-9. 1996
    ..It is similar in size and sequence to ImpC of the Salmonella typhimurium plasmid TP110 and to a protein (ORFfs) of the retronphage phi R67, both of which are also under the control of LexA...
  32. ncbi request reprint Structural properties and RNA-binding activities of two RNA recognition motifs of a mouse neural RNA-binding protein, mouse-Musashi-1
    Y Kurihara
    Department of Bioengineering, Faculty of Engineering, Yokohama National University, Japan
    Gene 186:21-7. 1997
    ....
  33. ncbi request reprint IFN-gamma induces expression of MHC class I molecules in adult mouse dorsal root ganglion neurones
    H Fujimaki
    Department of Immunology and Parasitology, School of Medicine, Yokohama City University, Japan
    Neuroreport 7:2951-5. 1996
    ..These results indicated that DRG neurones are able to express MHC class I molecules following IFN-gamma treatment and suggest that DRG neurones themselves are susceptible to recognition by cytotoxic T cells...
  34. ncbi request reprint [Cytotoxic activity and cytokine gene induction of Asp-hemolysin to vascular endothelial cells]
    T Kumagai
    First Department of Hygienic Chemistry, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan
    Yakugaku Zasshi 121:271-5. 2001
    ....
  35. ncbi request reprint A role of ghrelin in neuroendocrine and behavioral responses to stress in mice
    A Asakawa
    Second Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
    Neuroendocrinology 74:143-7. 2001
    ....
  36. ncbi request reprint The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn-finger protein aprataxin
    M C Moreira
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Illkirch, C U de Strasbourg, France
    Nat Genet 29:189-93. 2001
    ....
  37. pmc Cloning and physical mapping of the dnaA region of the Escherichia coli chromosome
    T Miki
    J Bacteriol 140:817-24. 1979
    ..29 Md, containing the 3.5-Md dnaA substitution segment, from the lambda i21 dnaA-2 DNA, inserting it into the sole BamHI cleavage site on pBR322...