Takahisa Furuta

Summary

Affiliation: Hamamatsu University School of Medicine
Country: Japan

Publications

  1. ncbi Individualized therapy for gastroesophageal reflux disease: potential impact of pharmacogenetic testing based on CYP2C19
    Takahisa Furuta
    Center for Clinical Research, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Mol Diagn Ther 16:223-34. 2012
  2. ncbi Effect of Helicobacter pylori infection and its eradication on nutrition
    T Furuta
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Aliment Pharmacol Ther 16:799-806. 2002
  3. ncbi Pharmacogenomics in chemotherapy for GI tract cancer
    Takahisa Furuta
    Center for Clinical Research, Hamamatsu University School of Medicine, 1 20 1, Handayama, Higashiku, Hamamatsu 431 3192, Japan
    J Gastroenterol 44:1016-25. 2009
  4. ncbi Triple therapy with ecabet sodium, amoxicillin and lansoprazole for 2 weeks as the rescue regimen for H. pylori infection
    Takahisa Furuta
    Center for Clinical Research, Hamamatsu University School of Medicine, Japan
    Intern Med 50:369-74. 2011
  5. ncbi Pharmacogenomics-based tailored versus standard therapeutic regimen for eradication of H. pylori
    T Furuta
    Center for Clinical Research, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Clin Pharmacol Ther 81:521-8. 2007
  6. ncbi Pharmacologic aspects of eradication therapy for Helicobacter pylori Infection
    Takahisa Furuta
    Center for Clinical Research, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higsahi Ku, Hamamatsu 431 3192, Japan
    Gastroenterol Clin North Am 39:465-80. 2010
  7. ncbi Therapeutic impact of CYP2C19 pharmacogenetics on proton pump inhibitor-based eradication therapy for Helicobacter pylori
    T Furuta
    First Department of Medicine, Department of Clinical Laboratories, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Methods Find Exp Clin Pharmacol 25:131-43. 2003
  8. ncbi Influences of different proton pump inhibitors on the anti-platelet function of clopidogrel in relation to CYP2C19 genotypes
    Takahisa Furuta
    Center for Clinical Research, Department of Pharmacology, Hamamatsu University School of Medicine, Hamamatsu 431 3192, Japan
    Br J Clin Pharmacol 70:383-92. 2010
  9. ncbi High-dose rabeprazole/amoxicillin therapy as the second-line regimen after failure to eradicate H. pylori by triple therapy with the usual doses of a proton pump inhibitor, clarithromycin and amoxicillin
    Takahisa Furuta
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Hepatogastroenterology 50:2274-8. 2003
  10. ncbi Pharmacogenomics of proton pump inhibitors
    Takahisa Furuta
    First Department of Medicine, Hamamatsu University School of Medicine, Handa yama, Japan
    Pharmacogenomics 5:181-202. 2004

Collaborators

Detail Information

Publications96

  1. ncbi Individualized therapy for gastroesophageal reflux disease: potential impact of pharmacogenetic testing based on CYP2C19
    Takahisa Furuta
    Center for Clinical Research, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Mol Diagn Ther 16:223-34. 2012
    ..CYP2C19 pharmacogenetics should be taken into consideration for the personalization of PPI-based therapy. However, the clinical usefulness of CYP2C19 genotype testing in GERD therapy should be verified in clinical studies...
  2. ncbi Effect of Helicobacter pylori infection and its eradication on nutrition
    T Furuta
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Aliment Pharmacol Ther 16:799-806. 2002
    ..To investigate the effects of Helicobacter pylori infection and eradication on nutrition...
  3. ncbi Pharmacogenomics in chemotherapy for GI tract cancer
    Takahisa Furuta
    Center for Clinical Research, Hamamatsu University School of Medicine, 1 20 1, Handayama, Higashiku, Hamamatsu 431 3192, Japan
    J Gastroenterol 44:1016-25. 2009
    ..Progress in this field would facilitate the further development of PGx-guided individualized therapy, which could be expected to increase therapeutic efficacy and decrease the risk of adverse events...
  4. ncbi Triple therapy with ecabet sodium, amoxicillin and lansoprazole for 2 weeks as the rescue regimen for H. pylori infection
    Takahisa Furuta
    Center for Clinical Research, Hamamatsu University School of Medicine, Japan
    Intern Med 50:369-74. 2011
    ..Ecabet sodium has an anti-H. pylori effect. We assessed the efficacy of ecabet sodium in the rescue therapy for the eradication of H. pylori...
  5. ncbi Pharmacogenomics-based tailored versus standard therapeutic regimen for eradication of H. pylori
    T Furuta
    Center for Clinical Research, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Clin Pharmacol Ther 81:521-8. 2007
    ..pylori infection allowed a higher eradication rate by the initial treatment without an increase of the final per-patient cost for successful eradication. However, the precise cost-effectiveness of this strategy remains to be determined...
  6. ncbi Pharmacologic aspects of eradication therapy for Helicobacter pylori Infection
    Takahisa Furuta
    Center for Clinical Research, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higsahi Ku, Hamamatsu 431 3192, Japan
    Gastroenterol Clin North Am 39:465-80. 2010
    ....
  7. ncbi Therapeutic impact of CYP2C19 pharmacogenetics on proton pump inhibitor-based eradication therapy for Helicobacter pylori
    T Furuta
    First Department of Medicine, Department of Clinical Laboratories, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Methods Find Exp Clin Pharmacol 25:131-43. 2003
    ..It is also necessary to recognize that there is a possible drug-drug interaction between some of the drugs used in this treatment regimen...
  8. ncbi Influences of different proton pump inhibitors on the anti-platelet function of clopidogrel in relation to CYP2C19 genotypes
    Takahisa Furuta
    Center for Clinical Research, Department of Pharmacology, Hamamatsu University School of Medicine, Hamamatsu 431 3192, Japan
    Br J Clin Pharmacol 70:383-92. 2010
    ..Therefore, the anti-platelet function of clopidogrel is attenuated by concomitant use of PPIs. There are differences in the metabolic disposition among different PPIs. Affinity to CYP2C19 differs among different PPIs...
  9. ncbi High-dose rabeprazole/amoxicillin therapy as the second-line regimen after failure to eradicate H. pylori by triple therapy with the usual doses of a proton pump inhibitor, clarithromycin and amoxicillin
    Takahisa Furuta
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Hepatogastroenterology 50:2274-8. 2003
    ....
  10. ncbi Pharmacogenomics of proton pump inhibitors
    Takahisa Furuta
    First Department of Medicine, Hamamatsu University School of Medicine, Handa yama, Japan
    Pharmacogenomics 5:181-202. 2004
    ..The CYP2C19 genotyping test is a useful tool for deciding on the optimal treatment regimen using a PPI, including a dual (PPI plus antibiotic) or a triple (PPI plus two antibiotics) therapy...
  11. ncbi Influence of CYP2C19 pharmacogenetic polymorphism on proton pump inhibitor-based therapies
    Takahisa Furuta
    First Department of Medicine, Hamamatsu University School of Medicine
    Drug Metab Pharmacokinet 20:153-67. 2005
    ..pylori infection by PPI-based therapies. For the better PPI-based treatment, doses and dosing schemes of PPIs should be optimized based on CYP2C19 genotype status...
  12. ncbi Polymorphism of interleukin-1beta affects the eradication rates of Helicobacter pylori by triple therapy
    Takahisa Furuta
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1, Handa yama, Hamamatsu 431 3192, Japan
    Clin Gastroenterol Hepatol 2:22-30. 2004
    ..pylori in the stomach. The aim of this study was to investigate whether IL-1beta polymorphism is associated with eradication rates of H. pylori by triple therapy with a proton pump inhibitor (PPI), amoxicillin, and clarithromycin...
  13. ncbi [13C]pantoprazole breath test as a predictor of the anti-platelet function of clopidogrel
    Takahisa Furuta
    Center for Clinical Research, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashi ku, Hamamatsu, 431 3192, Japan
    Eur J Clin Pharmacol 66:457-63. 2010
    ..The aim of this study was to determine whether the [(13)C]pantoprazole breath test, a recently developed tool used to measure CYP2C19 activity, can predict the anti-platelet efficacy of clopidogrel...
  14. ncbi Helicobacter pylori and non-malignant diseases
    Takahisa Furuta
    Center for Clinical Research, Hamamatsu University School of Medicine, 1 20 1, Handayama, Higashi ku, Hamamatsu, Japan
    Helicobacter 14:29-35. 2009
    ..It was also reported that for patients with functional dyspepsia, eradication of H. pylori offers a modest but significant benefit...
  15. ncbi The dual therapy with 4 times daily dosing of rabeprazole and amoxicillin as the 3rd rescue regimen for eradication of H. pylori
    Takahisa Furuta
    Center for Clinical Research, Hamamatsu University School of Medicine 1 20 1, Handayama, Higashi ku, Hamamatsu 431 3192, Japan
    Hepatogastroenterology 57:1314-9. 2010
    ..However, most of H. pylori strains are sensitive to amoxicillin. We tested whether dual therapy with the 4 times daily dosing of rabeprazole and amoxicillin was effective as the 3rd rescue regimen for eradication of H. pylori...
  16. ncbi CYP2C19 pharmacogenomics associated with therapy of Helicobacter pylori infection and gastro-esophageal reflux diseases with a proton pump inhibitor
    Takahisa Furuta
    1Hamamatsu University School of Medicine, Center for Clinical Research, 1 20 1, Handa yama, Higashi ku, Hamamatsu, 431 3192, Japan
    Pharmacogenomics 8:1199-210. 2007
    ..Recently, the CYP2C19 genotype-based tailored therapy for H. pylori infection has been found to be effective. CYP2C19 pharmacogenetics should be taken into consideration for the personalization of a PPI-based therapy...
  17. ncbi Modified allele-specific primer-polymerase chain reaction method for analysis of susceptibility of Helicobacter pylori strains to clarithromycin
    Takahisa Furuta
    Center for Clinical Research, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Gastroenterol Hepatol 22:1810-5. 2007
    ..Our aim in this study was to develop a polymerase chain reaction (PCR)-based assay that could determine these mutations in a single reaction tube...
  18. ncbi Effect of MDR1 C3435T polymorphism on cure rates of Helicobacter pylori infection by triple therapy with lansoprazole, amoxicillin and clarithromycin in relation to CYP 2C19 genotypes and 23S rRNA genotypes of H. pylori
    T Furuta
    Center for Clinical Research, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Aliment Pharmacol Ther 26:693-703. 2007
    ..Polymorphism in MDR1 is associated with variation in the plasma level of a proton pump inhibitor...
  19. ncbi Investigation of pretreatment prediction of proton pump inhibitor (PPI)-resistant patients with gastroesophageal reflux disease and the dose escalation challenge of PPIs-TORNADO study: a multicenter prospective study by the Acid-Related Symptom Research G
    Takahisa Furuta
    Center for Clinical Research, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashi ku, Hamamatsu 431 3192, Japan
    J Gastroenterol 46:1273-83. 2011
    ..We investigated the predictive marker of the efficacy of PPI for GERD patients including NERD and RE treated with standard and increased doses of a PPI...
  20. ncbi Influence of CYP2C19 polymorphism and Helicobacter pylori genotype determined from gastric tissue samples on response to triple therapy for H pylori infection
    Takahisa Furuta
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Clin Gastroenterol Hepatol 3:564-73. 2005
    ..We intended to determine SNPs of CYP2C19 and 23S rRNA of Helicobacter pylori by using rapid urease test (RUT)-positive gastric mucosal samples...
  21. ncbi CYP2C19 genotype is associated with symptomatic recurrence of GERD during maintenance therapy with low-dose lansoprazole
    Takahisa Furuta
    Center for Clinical Research, Hamamatsu University School of Medicine, 1 20 1, Handayama, Higashi ku, Hamamatsu, 431 3192, Japan
    Eur J Clin Pharmacol 65:693-8. 2009
    ..Because PPIs are metabolized by CYP2C19 in the liver, we investigated whether a patient's CYP2C19 genotype was associated with symptomatic recurrence of GERD during maintenance therapy with a low dose of a PPI...
  22. ncbi Effect of concomitant dosing of famotidine with lansoprazole on gastric acid secretion in relation to CYP2C19 genotype status
    T Furuta
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Aliment Pharmacol Ther 22:67-74. 2005
    ..Famotidine increases Helicobacter pylori-eradication rates by a triple lansoprazole/amoxicillin/clarithromycin therapy in patients with the rapid extensive metabolizer genotype of CYP2C19...
  23. ncbi Effects of genotypic differences in CYP2C19 status on cure rates for Helicobacter pylori infection by dual therapy with rabeprazole plus amoxicillin
    T Furuta
    First Department of Medicine, Hamamatsu University School of Medicine, Japan
    Pharmacogenetics 11:341-8. 2001
    ..Therefore, the genotyping test of CYP2C19 appears to be a clinically useful tool for the optimal dual treatment with rabeprazole plus amoxicillin...
  24. ncbi Effect of high-dose lansoprazole on intragastic pH in subjects who are homozygous extensive metabolizers of cytochrome P4502C19
    T Furuta
    First Department of Medicine and Department of Clinical Pharmacology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Clin Pharmacol Ther 70:484-92. 2001
    ..This study aimed to examine whether the CYP2C19 genotype status affected the acid-inhibitory effects of lansoprazole and to develop a strategy to overcome this pharmacogenetic problem...
  25. ncbi [13C]-pantoprazole breath test to predict CYP2C19 phenotype and efficacy of a proton pump inhibitor, lansoprazole
    T Furuta
    Center for Clinical Research, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Aliment Pharmacol Ther 30:294-300. 2009
    ..13)CO(2) is produced on metabolism of (13)C-labelled-pantoprazole ([(13)C]-pantoprazole) by CYP2C19...
  26. ncbi Esophageal mucosal injury with low-dose aspirin and its prevention by rabeprazole
    Mitsushige Sugimoto
    First Department of Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
    J Clin Pharmacol 50:320-30. 2010
    ..Aspirin induces esophageal mucosal injury in an acid-dependent manner. Concomitant proton-pump inhibitor therapy may prevent advanced effects of low-dose aspirin...
  27. ncbi Relationship between low-dose aspirin-induced gastric mucosal injury and intragastric pH in healthy volunteers
    Masafumi Nishino
    First Department of Medicine, Hamamatsu University School of Medicine, Higashi ku, Hamamatsu, Japan
    Dig Dis Sci 55:1627-36. 2010
    ..Gastric acid plays an important role in the pathogenesis of gastric mucosal lesions. We investigated whether aspirin-induced gastric mucosal injury might have any association with the intragastric pH...
  28. ncbi Treatment strategy to eradicate Helicobacter pylori infection: impact of pharmacogenomics-based acid inhibition regimen and alternative antibiotics
    Mitsushige Sugimoto
    Hamamatsu University School of Medicine, First Department of Medicine, 1 20 1 Handayama, Higashi ku, Hamamatsu, 431 3192, Japan
    Expert Opin Pharmacother 8:2701-17. 2007
    ..For attaining higher eradication rates, the tailored regimen based on the relevant pharmacogenomics is preferable...
  29. ncbi MDR1 C3435T polymorphism has no influence on developing Helicobacter pylori infection-related gastric cancer and peptic ulcer in Japanese
    Mitsushige Sugimoto
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashi ku, Hamamatsu, 431 3192, Japan
    Life Sci 83:301-4. 2008
    ..The aim of this study was to clarify the association of MDR1 C3435T polymorphism with susceptibility to gastric cancer and peptic ulcers in patients with Japanese H. pylori infection...
  30. ncbi Comparison of an increased dosage regimen of rabeprazole versus a concomitant dosage regimen of famotidine with rabeprazole for nocturnal gastric acid inhibition in relation to cytochrome P450 2C19 genotypes
    Mitsushige Sugimoto
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Clin Pharmacol Ther 77:302-11. 2005
    ..We compared the effectiveness of an increased dosage regimen of rabeprazole with that of a concomitant dosage regimen of rabeprazole with famotidine, relative to cytochrome P450 (CYP) 2C19 genotype status, on nocturnal acid inhibition...
  31. ncbi Initial 48-hour acid inhibition by intravenous infusion of omeprazole, famotidine, or both in relation to cytochrome P450 2C19 genotype status
    Mitsushige Sugimoto
    First Department of Medicine and Center for Clinical Research, Hamamatsu University School of Medicine, Shizuoka, Japan
    Clin Pharmacol Ther 80:539-48. 2006
    ....
  32. ncbi Influences of chymase and angiotensin I-converting enzyme gene polymorphisms on gastric cancer risks in Japan
    Mitsushige Sugimoto
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Shizuoka, 431 3192, Japan
    Cancer Epidemiol Biomarkers Prev 15:1929-34. 2006
    ..The aim of this study was to clarify the association of the chymase gene (CMA/B) and ACE polymorphisms with susceptibility to gastric cancer and peptic ulcer...
  33. ncbi Influences of proinflammatory and anti-inflammatory cytokine polymorphisms on eradication rates of clarithromycin-sensitive strains of Helicobacter pylori by triple therapy
    Mitsushige Sugimoto
    First Department of Medicine, Center for Clinical Research, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Clin Pharmacol Ther 80:41-50. 2006
    ..We investigated whether inflammation-related cytokine polymorphisms would influence the eradication rates of H pylori by a triple-therapy regimen...
  34. ncbi Preventive effects of lansoprazole and famotidine on gastric mucosal injury induced by low-dose aspirin in Helicobacter pylori-negative healthy volunteers
    Masafumi Nishino
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Clin Pharmacol 51:1079-86. 2011
    ..In this 7-day study, lansoprazole appeared to be more protective than famotidine against low-dose aspirin-induced mucosal injury but a larger well-controlled study is necessary to establish a definitive clinical benefit...
  35. ncbi Polymorphisms of matrix metalloproteinase-7 and chymase are associated with susceptibility to and progression of gastric cancer in Japan
    Mitsushige Sugimoto
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Gastroenterol 43:751-61. 2008
    ..pylori-infected patients. We aimed to clarify the association of MMP-7-181 and CMA/B polymorphisms with susceptibility to gastric cancer and cancer progression in H. pylori-infected patients...
  36. ncbi Effects of interleukin-10 gene polymorphism on the development of gastric cancer and peptic ulcer in Japanese subjects
    Mitsushige Sugimoto
    First Department of Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
    J Gastroenterol Hepatol 22:1443-9. 2007
    ..The aim of the present study was to clarify the association between the IL-10 polymorphism, one of the representative anti-inflammatory cytokines, and susceptibility to gastric cancer and peptic ulcer in Japan...
  37. ncbi Ability of rabeprazole to prevent gastric mucosal damage from clopidogrel and low doses of aspirin depends on CYP2C19 genotype
    Takahiro Uotani
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Japan
    Clin Gastroenterol Hepatol 10:879-885.e2. 2012
    ..It is not clear whether other drugs such as the antiplatelet agent clopidogrel also cause gastric mucosal injury or exacerbate aspirin-induced injury, or whether proton pump inhibitors prevent damage...
  38. ncbi Evidence that the degree and duration of acid suppression are related to Helicobacter pylori eradication by triple therapy
    Mitsushige Sugimoto
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Helicobacter 12:317-23. 2007
    ..We investigated whether gastric acid inhibition during an eradication therapy would influence the eradication rates attained by the triple therapy...
  39. ncbi Different effects of polymorphisms of tumor necrosis factor-alpha and interleukin-1 beta on development of peptic ulcer and gastric cancer
    Mitsushige Sugimoto
    First Department of Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
    J Gastroenterol Hepatol 22:51-9. 2007
    ..The aim of this study was to clarify the association of polymorphisms of interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha with susceptibility to peptic ulcer diseases and gastric cancer in Japan...
  40. ncbi Interleukin 1beta polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan
    Takahisa Furuta
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Gastroenterology 123:92-105. 2002
    ..This study aimed to examine effects of these polymorphisms on gastric acid secretion, atrophic gastritis, and risk of peptic ulcer in Japan...
  41. ncbi [Susceptibility to antibiotics and drug metabolism in patients with H. pylori infection refractory to the initial treatment--therapeutic strategy based on susceptibility to CAM and CYP2C19 polymorphism]
    Takahisa Furuta
    First Department of Medicine, Hamamatsu University School of Medicine
    Nippon Rinsho 63:426-33. 2005
  42. ncbi Role of angiotensinogen gene polymorphism on Helicobacter pylori infection-related gastric cancer risk in Japanese
    Mitsushige Sugimoto
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Shizuoka 431 3192, Japan
    Carcinogenesis 28:2036-40. 2007
    ..AGT-20 A/C polymorphism is associated with the plasma AGT and angiotensin II levels. The aim of this study was to clarify the association of AGT-20 A/C polymorphism with susceptibility to gastric cancer and peptic ulcer in Japanese...
  43. ncbi [High dose dual PPI/AMPC therapy for the treatment of Helicobacter pylori infection after failure of usual standard triple PPI/AMPC/CAM therapy: CYP2C19 polymorphism]
    Naohito Shirai
    First Department of Medicine, Hamamatsu University School of Medicine
    Nippon Rinsho 60:439-44. 2002
  44. ncbi Dual therapy with high doses of rabeprazole and amoxicillin versus triple therapy with rabeprazole, amoxicillin, and metronidazole as a rescue regimen for Helicobacter pylori infection after the standard triple therapy
    Naohito Shirai
    Department of Laboratory Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Eur J Clin Pharmacol 63:743-9. 2007
    ..We designed the prospective study to compare the efficacy of two rescue regimens after eradication failure by the standard triple therapy...
  45. ncbi Different dosage regimens of rabeprazole for nocturnal gastric acid inhibition in relation to cytochrome P450 2C19 genotype status
    Mitsushige Sugimoto
    First Department of Medicine, Hamamatsu University School of Medicine, Japan
    Clin Pharmacol Ther 76:290-301. 2004
    ..0 for no more than 4 hours a day (<16.7%). We aimed to develop optimal dosage regimens for rabeprazole to control nocturnal acidity in relation to cytochrome P450 (CYP) 2C19 genotypes...
  46. ncbi Resistance of Helicobacter pylori to quinolones and clarithromycin assessed by genetic testing in Japan
    Mihoko Yamade
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Gastroenterol Hepatol 26:1457-61. 2011
    ..Resistance of H. pylori to both clarithromycin and quinolone can be predicted by genetic testing. Here, we used this approach to evaluate the prevalence of clarithromycin- and quinolone-resistant strains of H. pylori in Japan...
  47. ncbi Influence of different proton pump inhibitors on activity of cytochrome P450 assessed by [(13)C]-aminopyrine breath test
    Chise Kodaira
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashi ku, Hamamatsu, 431 3192, Japan
    J Clin Pharmacol 52:432-9. 2012
    ..Omeprazole and lansoprazole at the standard doses inhibit CYP activity but rabeprazole does not, whereas high-dose omeprazole seems to induce CYPs...
  48. ncbi Effect of MDR1 C3435T polymorphism on lansoprazole in healthy Japanese subjects
    Chise Kodaira
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Eur J Clin Pharmacol 65:593-600. 2009
    ..We evaluated the influence of MDR1 C3435T polymorphism on the pharmacokinetics and pharmacodynamics of lansoprazole in Japanese subjects...
  49. ncbi Impact of acid inhibition on esophageal mucosal injury induced by low-dose aspirin
    Mitsushige Sugimoto
    Center for Clinical Research, Hamamatsu University School of Medicine, Shizuoka, Japan
    Digestion 85:9-17. 2012
    ..Recent studies have shown that aspirin can also induce esophageal mucosal injury. We resolved to determine the intragastric pH value necessary to prevent aspirin-induced esophageal mucosal injury...
  50. ncbi [Recent topics on important drugs for H. pylori eradication: Rabeprazole]
    Mitsushige Sugimoto
    First Department of Medicine, Hamamatsu University School of Medicine
    Nippon Rinsho 63:350-3. 2005
  51. ncbi A case of small bowel adenocarcinoma in a patient with Crohn's disease detected by PET/CT and double-balloon enteroscopy
    Chise Kodaira
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashi ku, Hamamatsu, Japan
    World J Gastroenterol 15:1774-8. 2009
    ..Since early diagnosis is extremely difficult in these cases, novel techniques, such as PET/CT and DBE, may be expected to help in making a preoperative diagnosis of the development of SBA in CD...
  52. ncbi Maintenance time of sedative effects after an intravenous infusion of diazepam: a guide for endoscopy using diazepam
    Mitsushige Sugimoto
    First Department of Medicine, Hamamatsu University School of Medicine, and Department of Gastroenterology, Enshu General Hospital, Hamamatsu, Japan
    World J Gastroenterol 14:5197-203. 2008
    ..To examine whether the sedative effects assessed by psychomotor tests would depend on the cytochrome P450 (CYP) 2C19 genotypes after an infusion regimen of diazepam commonly used for gastrointestinal endoscopy in Japan...
  53. ncbi Trastuzumab has opposing effects on SN-38-induced double-strand breaks and cytotoxicity in HER2-positive gastric cancer cells depending on administration sequence
    Mihoko Yamade
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Anticancer Res 32:105-14. 2012
    ..We investigated the effects of trastuzumab, an anti-HER2 humanized monoclonal antibody, on DNA breaks induced by SN-38, a topoisomerase-1 inhibitor, in gastric cancer cell lines positive or negative for HER2 expression...
  54. ncbi Determination of mutations of the 23S rRNA gene of Helicobacter pylori by allele specific primer-polymerase chain reaction method
    Akiko Nakamura
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Gastroenterol Hepatol 22:1057-63. 2007
    ..The aim of the present study was to develop the ASP-PCR assay for determining SNPs at positions 2,142 and 2,143 of the 23S rRNA gene of H. pylori...
  55. ncbi Norepinephrine suppresses IFN-γ and TNF-α production by murine intestinal intraepithelial lymphocytes via the β₁ adrenoceptor
    Yasuhiro Takayanagi
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu 431 3192, Japan
    J Neuroimmunol 245:66-74. 2012
    ..In IELs, β₁ AR agonist xamoterol mimicked the suppressive effects of NE. These results indicated NE regulates intestinal mucosal immune responses mediated by IELs via β₁ AR...
  56. ncbi Effect of genotypic differences in interleukin-1 beta on gastric acid secretion in Japanese patients infected with Helicobacter pylori
    Takahisa Furuta
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Med 112:141-3. 2002
  57. ncbi Effect of cytochrome P4502C19 genotypic differences on cure rates for gastroesophageal reflux disease by lansoprazole
    Takahisa Furuta
    First Department of Medicine, Hamamatsu University School of Medicine, Japan
    Clin Pharmacol Ther 72:453-60. 2002
    ..We assessed whether therapeutic effects of lansoprazole on gastroesophageal reflux disease (GERD) depended on the CYP2C19 genotype status in relation to the grade of GERD...
  58. ncbi Characteristics of non-erosive gastroesophageal reflux disease refractory to proton pump inhibitor therapy
    Mitsushige Sugimoto
    Center for Clinical Research, Hamamatsu University School of Medicine, Shizuoka Hamamatsu 431 3192, Japan
    World J Gastroenterol 17:1858-65. 2011
    ..To investigate whether potent acid inhibition is effective in non-erosive reflux disease (NERD) refractory to standard rabeprazole (RPZ) treatment...
  59. ncbi Prospective study of daily low-dose nedaplatin and continuous 5-fluorouracil infusion combined with radiation for the treatment of esophageal squamous cell carcinoma
    Satoshi Osawa
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    BMC Cancer 9:408. 2009
    ....
  60. ncbi Guggulsterone suppresses bile acid-induced and constitutive caudal-related homeobox 2 expression in gut-derived adenocarcinoma cells
    Takanori Yamada
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashi ku, Hamamatsu 431 3192, Japan
    Anticancer Res 30:1953-60. 2010
    ..Although bile acids induce caudal-related homeobox 2 (CdX2), a transcription factor essential for intestinal development and gut tumourigenesis, the effects of guggulsterone on regulation of CdX2 in the gut are unknown...
  61. ncbi Outcome of radiotherapy for gastric mucosa-associated lymphoid tissue lymphoma refractory to Helicobacter pylori eradication therapy
    Mitsushige Sugimoto
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu
    Intern Med 45:405-9. 2006
    ..CONCLUSIONS: Radiotherapy for patients with gastric MALT lymphoma refractory to H pylori eradication was effective without any critical acute or late adverse events...
  62. ncbi Superior vena cava syndrome associated with the metastasis of gastric adenocarcinoma to cervical lymph nodes
    Satoshi Osawa
    First Department of Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, 431-3192, Japan
    Dig Dis Sci 52:3343-5. 2007
  63. ncbi Serum pepsinogens as an early diagnostic marker of H. pylori eradication
    Naohito Shirai
    Department Laboratory Medicine, Hamamatsu University School of Medicine, Hamamatus, Japan
    Hepatogastroenterology 55:486-90. 2008
    ..pylori eradication. We studied whether the pepsinogen method could be an early diagnostic marker of H. pylori eradication even in patients persistently treated with a proton pump inhibitor...
  64. ncbi Glutamine supplementation increases Th1-cytokine responses in murine intestinal intraepithelial lymphocytes
    Yoshiaki Horio
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Cytokine 44:92-5. 2008
    ..Glutamine therefore had a direct effect on the production of selected IEL-derived Th1-cytokines, and enteral supplementation with glutamine may influence the intestinal immune responses mediated by IELs...
  65. ncbi Cecal vanishing tumor associated with cytomegalovirus infection in an immunocompetent elderly adult
    Shinsuke Kawasaki
    Shinsuke Kawasaki, Satoshi Osawa, Ken Sugimoto, Takahiro Uotani, Masafumi Nishino, Takanori Yamada, Mutsuhiro Ikuma, First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashi ku, Hamamatsu 431 3192, Japan
    World J Gastrointest Oncol 2:417-20. 2010
    ..Inflammatory pseudotumors associated with CMV infection should be considered as a differential diagnosis of tumorous lesions in the colon, even in immunocompetent adults...
  66. ncbi [A case of eosinophilic gastroenteritis accompanied with fasciitis of the extremities]
    Tomoharu Matsuura
    First Department of Medicine, Hamamatsu University School of Medicine, Japan
    Nihon Shokakibyo Gakkai Zasshi 108:444-50. 2011
    ..She soon developed resting pain in all limbs and MRI revealed fasciitis. Prednisolone was effective in treating both gastroenteritis and fasciitis...
  67. ncbi Influence of interleukin polymorphisms on development of gastric cancer and peptic ulcer
    Mitsushige Sugimoto
    Center for Clinical Research, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashi ku, Hamamatsu, Shizuoka 431 3192, Japan
    World J Gastroenterol 16:1188-200. 2010
    ..pylori eradication therapy in Western populations...
  68. ncbi A deficiency of gastric interstitial cells of Cajal accompanied by decreased expression of neuronal nitric oxide synthase and substance P in patients with type 2 diabetes mellitus
    Hirohiko Iwasaki
    First Department of Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan
    J Gastroenterol 41:1076-87. 2006
    ..CONCLUSIONS: These results suggest that lower gastric ICC, nNOS, and SP densities in patients with DM may be associated with the pathogenesis of diabetic gastroparesis...
  69. ncbi [Present status and future prospect of 3rd rescue regimen for H. pylori infection]
    Takahisa Furuta
    Center for Clinical Research, Hamamatsu University School of Medicine
    Nihon Rinsho 67:2303-8. 2009
    ..Especially, sitafloxacin, one of the fluoroquinolones, has the lower MIC for H. pylori in comparison with other fluoroquinolones, such as LVFX. Both therapies are expected to achieve the high eradication rate as the 3rd line therapy...
  70. ncbi Leukocyte adsorptive apheresis for the treatment of active ulcerative colitis: a prospective, uncontrolled, pilot study
    Hiroyuki Hanai
    Department of Endoscopic and Photodynamic Medicine, Hamamatsu University, Japan
    Clin Gastroenterol Hepatol 1:28-35. 2003
    ..GM are major sources of inflammatory cytokines, and in UC they are elevated with increased survival time. We investigated the possibility that reducing the level of these cells might promote remission of active UC...
  71. ncbi Comparison of lansoprazole and famotidine for gastric acid inhibition during the daytime and night-time in different CYP2C19 genotype groups
    N Shirai
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Aliment Pharmacol Ther 16:837-46. 2002
    ..The acid inhibitory effect of lansoprazole depends on the S-mephenytoin 4'-hydroxylase (CYP2C19) genotype status. The effect of famotidine is independent of this genotype...
  72. ncbi Effects of CYP2C19 genotypic differences in the metabolism of omeprazole and rabeprazole on intragastric pH
    N Shirai
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Aliment Pharmacol Ther 15:1929-37. 2001
    ..The therapeutic effects of rabeprazole are therefore assumed to be less affected by an individual's CYP2C19 status...
  73. ncbi Poor metabolizer genotype status of CYP2C19 is a risk factor for developing gastric cancer in Japanese patients with Helicobacter pylori infection
    M Sugimoto
    First Department of Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
    Aliment Pharmacol Ther 22:1033-40. 2005
    ..Cytochrome P450 2C19 (CYP2C19) polymorphism has been associated with the development of lung, liver or oesophageal cancer by detoxification of carcinogen(s) or activation of procarcinogen(s)...
  74. ncbi High speed clinical data retrieval system with event time sequence feature: with 10 years of clinical data of Hamamatsu University Hospital CPOE
    M Kimura
    Department of Medical Informatics, Hamamatsu University, School of Medicine, Hamamatsu, Japan
    Methods Inf Med 47:560-8. 2008
    ..even incorporating time sequence of causal relations...
  75. ncbi Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer
    T Furuta
    Hamamatsu University School of Medicine and Honda Motor Co, Ltd, Japan
    Ann Intern Med 129:1027-30. 1998
    ..Omeprazole is metabolized by S-mephenytoin 4'-hydroxylase (CYP2C19) in the liver. In persons with a poor-metabolizer genotype for CYP2C19, the therapeutic efficacy of omeprazole may be increased...
  76. ncbi Effect of genotypic differences in CYP2C19 on cure rates for Helicobacter pylori infection by triple therapy with a proton pump inhibitor, amoxicillin, and clarithromycin
    T Furuta
    First Department of Medicine, Hamamatsu University School of Medicine, Japan
    Clin Pharmacol Ther 69:158-68. 2001
    ..Proton pump inhibitors such as omeprazole and lansoprazole are mainly metabolized by CYP2C19 in the liver. The therapeutic effects of proton pump inhibitors are assumed to depend on CYP2C19 genotype status...
  77. ncbi Cure of refractory duodenal ulcer and infection caused by Helicobacter pylori by high doses of omeprazole and amoxicillin in a homozygous CYP2C19 extensive metabolizer patient
    T Furuta
    First Department of Medicine, Hamamatsu University School of Medicine, Japan
    Clin Pharmacol Ther 67:684-9. 2000
    ....
  78. ncbi Relationship between Helicobacter pylori infection and gastric metaplasia in the duodenal bulb in the pathogenesis of duodenal ulcer
    H Futami
    First Department of Medicine, Hamamatsu University School of Medicine, Japan
    J Gastroenterol Hepatol 14:114-9. 1999
    ..The aim of this study was to determine whether the amount of Helicobacter pylori and the extent of gastric metaplasia in the duodenal mucosa play critical roles in the pathogenesis of duodenal ulcer...
  79. ncbi Involvement of cyclooxygenase-2 in hyperplastic gastritis induced by Helicobacter pylori infection in C57BL/6 mice
    F Xiao
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Aliment Pharmacol Ther 15:875-86. 2001
    ..CONCLUSIONS: Our findings suggest that COX-2 is involved in the development of hyperplastic gastritis caused by H. pylori infection via the production of PGE2...
  80. ncbi Effects of Helicobacter pylori infection on gastric acid secretion and serum gastrin levels in Mongolian gerbils
    M Takashima
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Gut 48:765-73. 2001
    ..The aim of this study was to determine the effects of H pylori infection on gastric acid secretion and clarify its mechanisms with reference to interleukin 1beta (IL-1beta)...
  81. ncbi Study of transmission routes of Helicobacter pylori in relation to seroprevalence of hepatitis A virus
    T Furuta
    First Department of Medicine, Hamamatsu University School of Medicine, Handa Cho, Japan
    J Clin Microbiol 35:1891-3. 1997
    ..No statistically significant relationship was observed between seropositivity for HAV and that for H. pylori. Therefore, the fecal-oral spread of H. pylori is of limited relevance in Japan...
  82. ncbi Effects of cyclooxygenase-2 inhibitor on gastric acid secretion in Helicobacter pylori-infected C57BL/6 mice
    F Xiao
    First Dept. of Medicine, Hamamatsu University School of Medicine, 3600 Handa-cho, Hamamatsu, 431-3192, Japan
    Scand J Gastroenterol 36:577-83. 2001
    ..CONCLUSION: One of the mechanisms by which H. pylori infection inhibits gastric acid secretion is increased release of PGE2 produced by COX-2, which is induced by H. pylori infection...
  83. ncbi Cytokine responses of intraepithelial lymphocytes are regulated by histamine H(2) receptor
    Kosuke Takagaki
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashi ku, Hamamatsu, 431 3192, Japan
    J Gastroenterol 44:285-96. 2009
    ..We examined whether histamine has a direct effect on cytokine production by IELs and the involvement of histamine receptor subtypes...
  84. ncbi [High dose dual PPI/AMPC therapy for the treatment of Helicobacter pylori infection after failure of usual standard triple PPI/AMPC/CAM therapy]
    Naohito Shirai
    Department of Laboratory Medicine, Hamamatsu University School of Medicine
    Nippon Rinsho 63:438-41. 2005
  85. ncbi Hydroxylation of lansoprazole in poor metabolizers of CYP2C19
    Takahisa Furuta
    Br J Clin Pharmacol 61:361; author reply 361-2. 2006
  86. ncbi [Concomitant dosing of a H2 receptor antagonist (H2RA) with a triple therapy increases the cure rate of Helicobacter pylori infection]
    Keisuke Okudaira
    Second Department of Internal Medicine, National Defense Medical College
    Nippon Rinsho 63:391-6. 2005
  87. ncbi Controversy in polymorphisms of interleukin-1beta in gastric cancer risks
    Takahisa Furuta
    J Gastroenterol 39:501-3. 2004
  88. ncbi Impact of interleukin-1beta genetic polymorphisms on the development of hepatitis C virus-related hepatocellular carcinoma in Japan
    Yasuhito Tanaka
    Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Infect Dis 187:1822-5. 2003
    ....
  89. ncbi Interleukin 1beta gene polymorphism and hepatitis C virus-related hepatocellular carcinoma
    Anthony E T Yeo
    Hepatology 38:267-8; author reply 268-9. 2003
  90. ncbi Ecteinascidin 743: a novel anticancer drug with a unique mechanism of action
    Gregory J Aune
    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-4255, USA
    Anticancer Drugs 13:545-55. 2002
    ..Understanding the molecular pharmacology of Et743 should help in deciding which patients should receive Et743 treatments and which agents should be most useful in association...
  91. ncbi Agonistic antibody to TLR4/MD-2 protects mice from acute lethal hepatitis induced by TNF-alpha
    Sachiko Akashi-Takamura
    Division of Infectious Genetics, Institute of Medical Science, University of Tokyo, Japan
    J Immunol 176:4244-51. 2006
    ..These results demonstrated that an agonistic mAb to TLR4/MD-2 protected mice from LPS/d-galactosamine-induced acute lethal hepatitis by delivering a protective signal activating NF-kappaB through TLR4/MD-2...
  92. ncbi Protective roles of mast cells and mast cell-derived TNF in murine malaria
    Takahisa Furuta
    Department of Microbiology and Immunology, Division of Infectious Genetics, University of Tokyo, Japan
    J Immunol 177:3294-302. 2006
    ..These findings propose a novel mechanism that mast cells and mast cell-derived TNF play protective roles in malaria...
  93. ncbi Roles of the small intestine for induction of toll-like receptor 4-mediated innate resistance in naturally acquired murine toxoplasmosis
    Takahisa Furuta
    Division of Infectious Genetics, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Int Immunol 18:1655-62. 2006
    ..gondii ME49. These results suggest that the small intestine plays an important role in the induction of innate immunity in naturally acquired toxoplasmosis...
  94. ncbi Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans
    Shinobu Saijo
    Center for Experimental Medicine, The Institute of Medical Science, The University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Nat Immunol 8:39-46. 2007
    ..Thus, dectin-1 is required for immune responses to some fungal infections, as protective immunity to pneumocystis, but not to candida, required dectin-1 for the production of antifungal reactive oxygen species...
  95. ncbi Mast cell-mediated immune responses through IgE antibody and Toll-like receptor 4 by malarial peroxiredoxin
    Takahisa Furuta
    Division of Infectious Genetics, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Eur J Immunol 38:1341-50. 2008
    ....
  96. ncbi Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes
    Takahisa Furuta
    Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    J Biol Chem 278:20303-12. 2003
    ..These results demonstrate a conserved gammaH2AX response for double-strand breaks induced by replication fork collision. gammaH2AX foci are required for recruiting repair and checkpoint protein complexes to the replication break sites...