Toshihiro Hamada

Summary

Country: Japan

Publications

  1. doi request reprint Effects of cilnidipine on serum uric acid level and urinary nitrogen monoxide excretion in patients with hypertension
    Toshihiro Hamada
    Department of Regional Medicine, Tottori University Faculty of Medicine, Yonago, Japan
    Clin Exp Hypertens 34:470-3. 2012
  2. doi request reprint Effects of a low-dose antihypertensive diuretic in combination with losartan, telmisartan, or candesartan on serum urate levels in hypertensive patients
    Toshihiro Hamada
    Department of Cardiovascular Medicine, Faculty of Medicine, Tottori University, Yonago, Japan
    Arzneimittelforschung 60:71-5. 2010
  3. doi request reprint Uricosuric action of losartan via the inhibition of urate transporter 1 (URAT 1) in hypertensive patients
    Toshihiro Hamada
    Department of Cardiovascular Medicine, Faculty of Medicine, Tottori University, Yonago, Japan
    Am J Hypertens 21:1157-62. 2008
  4. ncbi request reprint Plasma levels of uridine correlate with blood pressure and indicators of myogenic purine degradation and insulin resistance in hypertensive patients
    Toshihiro Hamada
    Department of Cardiovascular Medicine, Graduate School of Medical Science, Tottori University, Yonago, Japan
    Circ J 71:354-6. 2007
  5. ncbi request reprint Status of uric acid management in hypertensive subjects
    Yasutaka Yamamoto
    Division of Regenerative Medicine and Therapeutics, Tottori University Graduate School of Medical Sciences, Yonago, Japan
    Hypertens Res 30:549-54. 2007
  6. ncbi request reprint Allopurinol reduces neointimal hyperplasia in the carotid artery ligation model in spontaneously hypertensive rats
    Yasutaka Yamamoto
    Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of Medical Science, Yonago, Japan
    Hypertens Res 29:915-21. 2006
  7. doi request reprint [Calcium antagonists: current and future applications based on new evidence. The mechanisms on lowering serum uric acid level by calcium channel blockers]
    Einosuke Mizuta
    Division of Molecular Medicine and Therapeutics, Department of Multidisciplinary Internal Medicine, Tottori University Faculty of Medicine, Japan
    Clin Calcium 20:45-50. 2010
  8. ncbi request reprint Inhibition of inward rectifier K+ currents by angiotensin II in rat atrial myocytes: lack of effects in cells from spontaneously hypertensive rats
    Kazuhiko Sonoyama
    Department of Cardiovascular Medicine, Tottori University Faculty of Medicine, Yonago, Japan
    Hypertens Res 29:923-34. 2006
  9. ncbi request reprint Current status of lipid management of hypertensive patients
    Koichi Matsubara
    Department of Cardiovascular Medicine, Tottori University Hospital, 36 1 Nishi machi, Yonago 683 8504, Japan
    Hypertens Res 26:699-704. 2003
  10. doi request reprint Effect of losartan and benzbromarone on the level of human urate transporter 1 mRNA
    Yora Nindita
    Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Institute of Regenerative Medicine and Biofunction, Tottori University Graduate School of Medical Science, Yonago, Japan
    Arzneimittelforschung 60:186-8. 2010

Collaborators

Detail Information

Publications17

  1. doi request reprint Effects of cilnidipine on serum uric acid level and urinary nitrogen monoxide excretion in patients with hypertension
    Toshihiro Hamada
    Department of Regional Medicine, Tottori University Faculty of Medicine, Yonago, Japan
    Clin Exp Hypertens 34:470-3. 2012
    ..Therefore, cilnidipine has a profound antihypertensive effect and may reduce the serum uric acid level and increase NO production in the kidney...
  2. doi request reprint Effects of a low-dose antihypertensive diuretic in combination with losartan, telmisartan, or candesartan on serum urate levels in hypertensive patients
    Toshihiro Hamada
    Department of Cardiovascular Medicine, Faculty of Medicine, Tottori University, Yonago, Japan
    Arzneimittelforschung 60:71-5. 2010
    ..A combination therapy of a low-dose antihypertensive diuretic with an angiotensin II receptor blocker (ARB) may have unfavorable effects on serum urate levels...
  3. doi request reprint Uricosuric action of losartan via the inhibition of urate transporter 1 (URAT 1) in hypertensive patients
    Toshihiro Hamada
    Department of Cardiovascular Medicine, Faculty of Medicine, Tottori University, Yonago, Japan
    Am J Hypertens 21:1157-62. 2008
    ..However, it is still unknown whether the inhibitory effect of losartan on URAT1 contributes to its uricosuric action in humans...
  4. ncbi request reprint Plasma levels of uridine correlate with blood pressure and indicators of myogenic purine degradation and insulin resistance in hypertensive patients
    Toshihiro Hamada
    Department of Cardiovascular Medicine, Graduate School of Medical Science, Tottori University, Yonago, Japan
    Circ J 71:354-6. 2007
    ..The relationship between plasma uridine levels and blood pressure (BP), and indicators of muscular purine degradation and insulin resistance (IR) has been evaluated in hypertensive (HT) patients...
  5. ncbi request reprint Status of uric acid management in hypertensive subjects
    Yasutaka Yamamoto
    Division of Regenerative Medicine and Therapeutics, Tottori University Graduate School of Medical Sciences, Yonago, Japan
    Hypertens Res 30:549-54. 2007
    ..Thus, more attention to uric acid management is necessary in hypertensive subjects to prevent cardiovascular diseases...
  6. ncbi request reprint Allopurinol reduces neointimal hyperplasia in the carotid artery ligation model in spontaneously hypertensive rats
    Yasutaka Yamamoto
    Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Tottori University Graduate School of Medical Science, Yonago, Japan
    Hypertens Res 29:915-21. 2006
    ..In conclusion, uric acid is a potent stimulator of VSMC proliferation, and allopurinol prevented vascular remodeling in SHR at least in part by inhibiting uric acid concentration...
  7. doi request reprint [Calcium antagonists: current and future applications based on new evidence. The mechanisms on lowering serum uric acid level by calcium channel blockers]
    Einosuke Mizuta
    Division of Molecular Medicine and Therapeutics, Department of Multidisciplinary Internal Medicine, Tottori University Faculty of Medicine, Japan
    Clin Calcium 20:45-50. 2010
    ..Hyperuricemia is considered to be a risk factor of not only gout but also renal and cardiovascular diseases, thus, it is important to use CCBs without adverse effect on uric acid metabolisms...
  8. ncbi request reprint Inhibition of inward rectifier K+ currents by angiotensin II in rat atrial myocytes: lack of effects in cells from spontaneously hypertensive rats
    Kazuhiko Sonoyama
    Department of Cardiovascular Medicine, Tottori University Faculty of Medicine, Yonago, Japan
    Hypertens Res 29:923-34. 2006
    ..The reduced coupling of AT, with Gialpha. proteins may underlie the unresponsiveness of atrial IK1 to Ang II in SHR cells...
  9. ncbi request reprint Current status of lipid management of hypertensive patients
    Koichi Matsubara
    Department of Cardiovascular Medicine, Tottori University Hospital, 36 1 Nishi machi, Yonago 683 8504, Japan
    Hypertens Res 26:699-704. 2003
    ..This was most marked for patients in category C...
  10. doi request reprint Effect of losartan and benzbromarone on the level of human urate transporter 1 mRNA
    Yora Nindita
    Division of Regenerative Medicine and Therapeutics, Department of Genetic Medicine and Regenerative Therapeutics, Institute of Regenerative Medicine and Biofunction, Tottori University Graduate School of Medical Science, Yonago, Japan
    Arzneimittelforschung 60:186-8. 2010
    ..These results indicate that losartan decreases the level of human URAT1 mRNA, which may underlie the uricosuric action of losartan in hypertensive patients treated with serum urate lowering agents...
  11. ncbi request reprint The status of hypertension management in Japan in 2000
    Yasutaka Yamamoto
    Department of Cardiovascular Medicine, Tottori University Hospital, Yonago, Japan
    Hypertens Res 25:717-25. 2002
    ..Based on current evidence, the management of hypertension should be individualized, with the blood pressure target level and antihypertensive medications chosen on the basis of age and comorbidity...
  12. ncbi request reprint Effect of the angiotensin II receptor antagonist losartan on uric acid and oxypurine metabolism in healthy subjects
    Toshihiro Hamada
    Department of Cardiovascular Medicine, Tottori University Hospital, Yonago
    Intern Med 41:793-7. 2002
    ..The acute effects of the angiotensin II receptor antagonist losartan on uric acid and oxypurine metabolism were evaluated...
  13. ncbi request reprint [How do we set the standard value of serum uric acid levels?]
    Toshihiro Hamada
    Division of Molecular Medicine and Therapeutics, Tottori University, Faculty of Medicine
    Nihon Rinsho 66:723-7. 2008
    ..In contrast, hyperglycemia and excess salt ingestion are conductive to accelerate urate excretion. Physicians should notice representative factors fluctuating serum uric acid levels as described above...
  14. ncbi request reprint [Drug-induced hyperuricemia]
    Toshihiro Hamada
    Department of Multidisciplinary Internal Medicine, Division of Molecular Medicine and Therapeutics, Tottori University, Faculty of Medicine
    Nihon Rinsho 61:333-7. 2003
  15. ncbi request reprint Small extra-adrenal pheochromocytoma causing severe hypertension in an elderly patient
    Einosuke Mizuta
    Department of Genetic Medicine and Regenerative Medicine and Therapeutics, Institute of Regenerative Medicine and Biofunction, Tottori University Graduate School of Medical Science, Yonago, Japan
    Hypertens Res 29:635-8. 2006
    ....
  16. ncbi request reprint Effects of angiotensin II on the action potential durations of atrial myocytes in hypertensive rats
    Kazuhiko Sonoyama
    Department of Cardiovascular Medicine, Tottori University Faculty of Medicine, Yonago, Japan
    Hypertens Res 28:173-9. 2005
    ..Our findings indicated that Ang II caused atrial arrhythmias in hypertensive patients by shortening the effective refractory period of the atrium...
  17. ncbi request reprint Decreased excretion of antimicrobial proteins and peptides in saliva of patients with oral candidiasis
    Toyohiro Tanida
    Department of Oral Surgery, Kochi Medical School, Kochi, Japan
    J Oral Pathol Med 32:586-94. 2003
    ....