Makoto Tanaka

Summary

Affiliation: Gunma University
Country: Japan

Publications

  1. ncbi request reprint Cerebral blood flow and oxygen metabolism in patients with progressive dementia and amyotrophic lateral sclerosis
    Makoto Tanaka
    Department of Neurology, Gunma University School of Medicine, Showamachi, Maebashi, Gunma 371 8511, Japan
    Neurol Res 25:351-6. 2003
  2. ncbi request reprint Structural changes in the midbrain with aging and Parkinson's disease: an MRI study
    Makoto Sohmiya
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22, Showa machi, Maebashi, Gunma 371 8511, Japan
    Neurobiol Aging 25:449-53. 2004
  3. ncbi request reprint Cerebral blood flow and oxygen metabolism in vascular dementia evaluated by positron emission tomography: importance of frontal lobe hypoperfusion and hypometabolism
    Makoto Tanaka
    Department of Neurology, Gunma University School of Medicine, 3 39 33 Showa machi, Maebashi, Gunma 371 8511, Japan
    Ann N Y Acad Sci 977:135-40. 2002
  4. ncbi request reprint An increase of oxidized coenzyme Q-10 occurs in the plasma of sporadic ALS patients
    Makoto Sohmiya
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showamachi, Maebashi, Gunma 371 8511, Japan
    J Neurol Sci 228:49-53. 2005
  5. ncbi request reprint Antioxidant properties of carvedilol: inhibition of lipid peroxidation, protein oxidation and superoxide generation
    Yoko Suzuki
    Department of Neurology, Gunma University School of Medicine, 3 39 22 Showamachi, Maebashi, Gunma 371 8511, Japan
    Neurol Res 25:749-53. 2003
  6. ncbi request reprint Redox status of plasma coenzyme Q10 indicates elevated systemic oxidative stress in Parkinson's disease
    Makoto Sohmiya
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showamachi, Maebashi, Gunma 371 8511, Japan
    J Neurol Sci 223:161-6. 2004
  7. ncbi request reprint Synergistic inhibition of lipid peroxidation by vitamin E and a dopamine agonist, cabergoline
    Makoto Sohmiya
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showamachi, Maebashi, Gunma 371 8511, Japan
    Neurol Res 26:418-21. 2004
  8. ncbi request reprint Identification of nitrated proteins in the normal rat brain using a proteomics approach
    Yoko Suzuki
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Neurol Res 27:630-3. 2005
  9. ncbi request reprint Treatment of vascular dementia
    Koichi Okamoto
    Department of Neurology, Gunma University School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Ann N Y Acad Sci 977:507-12. 2002
  10. ncbi request reprint [A case of middle-aged onset sialidosis type I]
    Yuka Sakazume
    Department of Neurology, Gunma University Graduate School of Medicine
    Rinsho Shinkeigaku 44:541-4. 2004

Collaborators

  • Koichi Okamoto
  • Makoto Sohmiya
  • Akira Omori
  • Yuji Mizuno
  • H Yamauchi
  • Diana S Woodruff-Pak
  • Hiroyuki Nishikawa
  • Gary L Wenk
  • T Horie
  • S Sasaki
  • Minoru Narita
  • T Osanai
  • Shuko Tachibana
  • Shigeyuki Chaki
  • Yoko Suzuki
  • Toru Kita
  • Yuka Sakazume
  • Toshihiko Yoshida
  • Yoshinori Yoshida
  • Shino Umehara
  • Yoshiko Osaka
  • Masaya Tachibana
  • Naomi Ito
  • Mizuho Morioka
  • Yasuji Ueda
  • Junji Shibahara
  • Kozo Matsubayashi
  • Yoshihisa Tsuji
  • Kazuaki Takamori
  • Chieko Inoue
  • Shinobu Tano
  • Makoto Uesugi
  • Yoji Kojima
  • Koh Ono
  • Tomoyuki Nakamura
  • Yasuhiro Nakashima
  • Kiyonori Togi
  • Hiromi Yamamoto
  • Hironobu Matsumae
  • Einosuke Tanaka
  • Shinichi Inomata
  • Katsuya Honda
  • Toshiaki Nishikawa
  • Hidenori Toyooka
  • Takako Nakamura
  • Masayuki Miyabe
  • Sachiyo Ichinose
  • Keiko Kazuma
  • Yasuhiro Masubuchi
  • Akiteru Goto
  • Noriko Hirayama
  • Katsumi Doh-ura
  • Sachiko Yamaguchi
  • Sumi Nishihara
  • Hidenao Fukuyama
  • Masabumi Shibuya
  • Itsuo Isobe
  • Takahiro Mezaki
  • Eiji Nanba
  • Kazunori Samata
  • Toshiro Niki
  • Hisao Ikeya
  • Koshi Arai
  • Ken Taniguchi
  • Shiro Nakaike
  • Hiroshi Kanamori
  • Takehiro Yamagishi
  • Masayuki Yokode
  • Rika Tominaga
  • Masashi Fukayama
  • Tadayasu Okazaki
  • Gaku Murakami
  • Jun Nakajima
  • Yoshio Ikeda
  • Shiho Hirota
  • Nicholas K Gonatas
  • Yukiko Hashimoto

Detail Information

Publications36

  1. ncbi request reprint Cerebral blood flow and oxygen metabolism in patients with progressive dementia and amyotrophic lateral sclerosis
    Makoto Tanaka
    Department of Neurology, Gunma University School of Medicine, Showamachi, Maebashi, Gunma 371 8511, Japan
    Neurol Res 25:351-6. 2003
    ..The metabolic and perfusional changes in the cerebral cortex of ALS patients are likely to depend on upper motor neuron involvement, but they are not confined to the neurons of the corticospinal tract...
  2. ncbi request reprint Structural changes in the midbrain with aging and Parkinson's disease: an MRI study
    Makoto Sohmiya
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22, Showa machi, Maebashi, Gunma 371 8511, Japan
    Neurobiol Aging 25:449-53. 2004
    ..These findings based on a large-scale morphometric study provide essential information to evaluate conventional MR images of PD...
  3. ncbi request reprint Cerebral blood flow and oxygen metabolism in vascular dementia evaluated by positron emission tomography: importance of frontal lobe hypoperfusion and hypometabolism
    Makoto Tanaka
    Department of Neurology, Gunma University School of Medicine, 3 39 33 Showa machi, Maebashi, Gunma 371 8511, Japan
    Ann N Y Acad Sci 977:135-40. 2002
  4. ncbi request reprint An increase of oxidized coenzyme Q-10 occurs in the plasma of sporadic ALS patients
    Makoto Sohmiya
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showamachi, Maebashi, Gunma 371 8511, Japan
    J Neurol Sci 228:49-53. 2005
    ..0+/-9.3%; controls=3.2+/-0.9%, P<0.0001) were observed. Moreover, %CoQ-10 correlated significantly with the duration of illness (rho=0.494, P=0.0315). Our finding suggests systemic oxidative stress in the pathogenesis of sALS...
  5. ncbi request reprint Antioxidant properties of carvedilol: inhibition of lipid peroxidation, protein oxidation and superoxide generation
    Yoko Suzuki
    Department of Neurology, Gunma University School of Medicine, 3 39 22 Showamachi, Maebashi, Gunma 371 8511, Japan
    Neurol Res 25:749-53. 2003
    ..Carvedilol also suppressed superoxide generation of human neutrophils. These properties of carvedilol should be suitable for treating hypertension resulting in cerebro- and cardiovascular diseases...
  6. ncbi request reprint Redox status of plasma coenzyme Q10 indicates elevated systemic oxidative stress in Parkinson's disease
    Makoto Sohmiya
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showamachi, Maebashi, Gunma 371 8511, Japan
    J Neurol Sci 223:161-6. 2004
    ..A slight but significant elevation in %CoQ-10 was observed in PD patients when compared with age/gender-matched normal subjects, suggesting elevated systemic oxidative stress in PD patients...
  7. ncbi request reprint Synergistic inhibition of lipid peroxidation by vitamin E and a dopamine agonist, cabergoline
    Makoto Sohmiya
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showamachi, Maebashi, Gunma 371 8511, Japan
    Neurol Res 26:418-21. 2004
    ..These results suggest that cabergoline may have a neuroprotective effect on the substantia nigra of Parkinsonian patients because of its synergistic antioxidant activity with vitamin E as well as its action on dopamine receptor...
  8. ncbi request reprint Identification of nitrated proteins in the normal rat brain using a proteomics approach
    Yoko Suzuki
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Neurol Res 27:630-3. 2005
    ..The nitration of tyrosine has been suggested to play a role in the pathogenesis of neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD) and Alzheimer's disease (AD)...
  9. ncbi request reprint Treatment of vascular dementia
    Koichi Okamoto
    Department of Neurology, Gunma University School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Ann N Y Acad Sci 977:507-12. 2002
    ..We review recent situations in prevention and treatment of vascular dementia...
  10. ncbi request reprint [A case of middle-aged onset sialidosis type I]
    Yuka Sakazume
    Department of Neurology, Gunma University Graduate School of Medicine
    Rinsho Shinkeigaku 44:541-4. 2004
    ..These mutations have been reported in Japanese sialidosis type II (P80L) and I (V217M). Further studies are required to reveal effects of gene mutations on residual enzyme activities and phenotypes...
  11. ncbi request reprint [A case of herpes simplex encephalitis with noticeable findings of SPECT]
    Shinobu Tano
    Department of Neurology, Gunma University School of Medicine
    Rinsho Shinkeigaku 42:966-9. 2002
    ..Decreased signal of ECD in the lesion where IMP uptake was increased could be due to decreased esterase activity. This report suggests that ECD-SPECT could fail to detect cerebral blood flow in the lesion with severe metabolic damage...
  12. ncbi request reprint A case of mixed connective tissue disease showing a lymphoid follicle in muscle pathology
    Chieko Inoue
    Department of Neurology, Gunma University School of Medicine, 3 39 22 Showa machi, 371 8511 Maebashi, Japan
    J Neurol Sci 215:119-21. 2003
    ..A lymphoid follicle is a rare pathological finding in inflammatory myopathies. The immunohistochemical findings suggest that the lymphoid follicle would be involved in the specific role for the pathogenesis of MCTD...
  13. ncbi request reprint Antioxidant properties of cabergoline: inhibition of brain auto-oxidation and superoxide anion production of microglial cells in rats
    Toshihiko Yoshida
    Department of Neurology, Gunma University School of Medicine, Showa machi, Maebashi, Gunma 371 8511, Japan
    Neurosci Lett 330:1-4. 2002
    ..While cabergoline is commonly used to treat the motor dysfunction of Parkinson's disease, it may also be effective in inhibiting oxidative stress, a possible mechanism of dopaminergic neuronal degeneration in Parkinson's disease...
  14. ncbi request reprint Masses of phosphorylated neurofilaments are associated with abnormal golgi apparatus of anterior horn neurons of beta, beta'-iminodipropionitrile-intoxicated rats
    Makoto Uesugi
    Department of Neurology, Gunma University School of Medicine, Maebashi, Japan
    Neuropathology 22:61-5. 2002
    ..The results suggest that masses of phosphorylated neurofilaments are associated with structural abnormalities of the GA...
  15. ncbi request reprint Health-related quality of life among persons living in Japan with a permanent colostomy
    Naomi Ito
    Department of Adult Nursing Terminal and Long Term Care Nursing, School of Health Sciences and Nursing, Graduate School of Medicine, The University of Tokyo, Japan
    J Wound Ostomy Continence Nurs 32:178-83; quiz 184-5. 2005
    ..To compare the health-related quality of life (HRQOL) of persons with a permanent colostomy to that of the general Japanese population and explore the factors influencing HRQOL...
  16. ncbi request reprint [Diagnostic approach to dementia in Gunma University Hospital supporting Dementia Gunma Network]
    Makoto Tanaka
    Nihon Ronen Igakkai Zasshi 42:45-8. 2005
  17. ncbi request reprint Regional cerebral blood flow abnormalities in nondemented patients with memory impairment
    Makoto Tanaka
    Department of Geriatric Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    J Neuroimaging 12:112-8. 2002
    ..However, little is known about patterns of regional cerebral blood flow abnormalities and their prognostic significance in these patients...
  18. ncbi request reprint Nefiracetam and physostigmine: separate and combined effects on learning in older rabbits
    Diana S Woodruff-Pak
    Department of Psychology, Temple University, 1701 North 13th Street, Philadelphia, PA 19122, USA
    Neurobiol Aging 25:807-16. 2004
    ....
  19. ncbi request reprint Primary pulmonary paraganglioma: report of a functioning case with immunohistochemical and ultrastructural study
    Junji Shibahara
    Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Am J Surg Pathol 28:825-9. 2004
    ..On the basis of our experience, our case is a bona fide primary pulmonary paraganglioma, a tumor heretofore subject to considerable skepticism...
  20. ncbi request reprint Pharmacokinetics and disposition of DY-9760e, a novel calmodulin antagonist, in rats and monkeys
    Shuko Tachibana
    Drug Metabolism and Physicochemistry Research Laboratories, DaĆ¼chi Pharmaceutical Co, Ltd, Tokyo, Japan
    Arzneimittelforschung 55:135-44. 2005
    ..These results indicate that DY-9760e is eliminated mainly through hepatic metabolic clearance in both rats and monkeys...
  21. ncbi request reprint Donepezil and athetosis in an elderly patient with Alzheimer's disease
    Makoto Tanaka
    J Am Geriatr Soc 51:889-90. 2003
  22. ncbi request reprint The long-term effects of nefiracetam on learning in older rabbits
    Diana S Woodruff-Pak
    Research and Technology Development, Albert Einstein Healthcare Network, Korman Suite 100, 5501 Old York Road, Philadelphia, PA 19141, USA
    Behav Brain Res 136:299-308. 2002
    ..In this experiment, nefiracetam had a significant effect long after drug administration had ceased. Prolonged administration of nefiracetam may have ameliorating effects greater than those observed in only 15 days of drug administration...
  23. ncbi request reprint Effects of sevoflurane anesthesia on carotid-cardiac baroreflex responses in humans
    Shino Umehara
    Department of Anesthesia, Akita University School of Medicine, Akita City, Japan
    Anesth Analg 102:38-44. 2006
    ..Sevoflurane-induced hypotension, which produced vagal withdrawal, did not play an important role in depressing cardio-vagal reflex function...
  24. ncbi request reprint Effect of propofol on ropivacaine metabolism in human liver microsomes
    Yoshiko Osaka
    Graduate School, University of Tsukuba, Tsukuba, Japan
    J Anesth 20:60-3. 2006
    ..The IC50 of propofol was 34.9 micromol.l(-1). Propofol shows a competitive inhibitory effect on the metabolism of ropivacaine (i.e., PPX production mediated by CYP3A4) in human CYP systems in vitro...
  25. ncbi request reprint Effect of vasoconstrictor coupling factor 6 on gene expression profile in human vascular endothelial cells: enhanced release of asymmetric dimethylarginine
    Makoto Tanaka
    Second Department of Internal Medicine, Hirosaki University School of Medicine, Osaka, Japan
    J Hypertens 24:489-97. 2006
    ..We investigated the effect of CF6 on the gene expression profile in human umbilical vein endothelial cells...
  26. ncbi request reprint CCN1 protects cardiac myocytes from oxidative stress via beta1 integrin-Akt pathway
    Yoshinori Yoshida
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 355:611-8. 2007
    ..The antiapoptotic effect of CCN1 on cardiac myocytes together with its proangiogenic property could be beneficial in the treatment of ischemic heart disease...
  27. ncbi request reprint Acyl glucuronidation of fluoroquinolone antibiotics by the UDP-glucuronosyltransferase 1A subfamily in human liver microsomes
    Masaya Tachibana
    Department of Biopharmaeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Drug Metab Dispos 33:803-11. 2005
    ....
  28. ncbi request reprint Antipsychotic action of selective group II metabotropic glutamate receptor agonist MGS0008 and MGS0028 on conditioned avoidance responses in the rat
    Kazuaki Takamori
    Research Management Section, Medicinal Research Laboratories, Taisho Pharmaceutical Co Ltd, 1 403, Yoshino cho, Saitama, Japan
    Life Sci 73:1721-8. 2003
    ..Since this effect is seen with a wide range of antipsychotics, such as haloperidol and clozapine [Life Sciences 71 (2002) 947], group II mGluR agonists deserve further attention for possible antipsychotic activity...
  29. ncbi request reprint Ulcerative colitis: factors affecting difficulties of life and psychological well being of patients in remission
    Makoto Tanaka
    Department of Adult Nursing Terminal and Long Term Care Nursing, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Clin Nurs 14:65-73. 2005
    ..This study was conducted to elucidate factors that influence perception of difficulties of life and psychological well being of patients with ulcerative colitis in remission...
  30. ncbi request reprint [Therapy for patients with early-stage Parkinson's disease]
    Makoto Tanaka
    Nihon Naika Gakkai Zasshi 92:1426-31. 2003
  31. ncbi request reprint [Acceptance of memory impairment and satisfaction with life in patients with mild to moderate Alzheimer's disease]
    Mizuho Morioka
    Department of Geriatric Medicine, Kyoto University
    Nihon Ronen Igakkai Zasshi 41:534-41. 2004
    ..The present study indicated that we have to provide individual care and support for AD patients considering their level of acceptance of memory impairment...
  32. ncbi request reprint Heidenhain variant of Creutzfeldt-Jakob disease: diffusion-weighted MRI and PET characteristics
    Yoshihisa Tsuji
    Department of Geriatric Medicine, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    J Neuroimaging 14:63-6. 2004
    ..Diffusion-weighted MRI and PE1 in combination with visual evoked potential recording and 14-3-3 protein detection may be useful for the early diagnosis of CJD...
  33. ncbi request reprint Prediction of psychiatric response to donepezil in patients with mild to moderate Alzheimer's disease
    Makoto Tanaka
    Department of Social Service, Kyoto University Hospital, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    J Neurol Sci 225:135-41. 2004
    ..The present study suggested usefulness of SPECT imaging in the prediction of behavioral response to donepezil among AD patients even with similar psychiatric symptoms and cognitive functions...
  34. ncbi request reprint A novel low molecular weight VEGF receptor-binding antagonist, VGA1102, inhibits the function of VEGF and in vivo tumor growth
    Yasuji Ueda
    Taisho Pharmaceutical Co, Ltd, 1 403 Yoshino cho, Kita ku, 331 9530 Saitama, Japan
    Cancer Chemother Pharmacol 54:16-24. 2004
    ..These results suggest that VGA1102 inhibits VEGF function resulting in inhibition of tumor angiogenesis, which led to suppression of growth of human tumors transplanted into nude mice...
  35. ncbi request reprint Protease-activated receptor-2 (PAR-2)-related peptides induce tear secretion in rats: involvement of PAR-2 and non-PAR-2 mechanisms
    Hiroyuki Nishikawa
    Research and Development Center, Fuso Pharmaceutical Industries Ltd, Osaka, Japan
    J Pharmacol Exp Ther 312:324-31. 2005
    ....
  36. ncbi request reprint Dietary intake and body composition of Japanese ulcerative colitis patients in remission
    Makoto Tanaka
    Department of Adult Nursing Palliative Care Nursing, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan hmakoto tkyumin ac jp
    Gastroenterol Nurs 30:357-62. 2007
    ..The authors suggest further research to clarify the problems that unnecessary dietary restriction cause for ulcerative colitis patients who are in remission...