Research Topics
| K TakataSummaryAffiliation: Gunma University Country: Japan Publications
| Collaborators
|
Detail Information
Publications
Aquaporins: water channel proteins of the cell membraneKuniaki Takata
Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine, Showa machi 3 39 22, Maebashi, Gunma 371 8511, Japan
Prog Histochem Cytochem 39:1-83. 2004..AQP9 is present in the liver and leukocytes. AQP10 is expressed in the intestine. The diverse and characteristic distribution of aquaporins in the body suggests their important and specific roles in each organ...
Localization and trafficking of aquaporin 2 in the kidneyKuniaki Takata
Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma, 371 8511, Japan
Histochem Cell Biol 130:197-209. 2008..Actin plays an important role in the intracellular trafficking of AQP2. Recent findings have shed light on the molecular basis that controls the trafficking of AQP2...- Molecular mechanisms and drug development in aquaporin water channel diseases: water channel aquaporin-2 of kidney collecting duct cellsKuniaki Takata
Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine, Maebashi, Japan
J Pharmacol Sci 96:255-9. 2004..Comparison of the intracellular localization of AQP2 with GLUT4 suggests distinct regulation of AQP2 trafficking... - Aquaporin-2 (AQP2): its intracellular compartment and traffickingK Takata
Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
Cell Mol Biol (Noisy-le-grand) 52:34-9. 2006..Some of AQP2 is excreted as exosomes. Actin cytoskeleton plays important roles in the trafficking of AQP2. Analyses of molecules found in AQP2-containing vesicles will shed light on the mechanism of AQP2 translocation... - Immunolocalization of the water channel, aquaporin-5 (AQP5), in the rat digestive systemToshiyuki Matsuzaki
Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine, Maebashi, Japan
Arch Histol Cytol 66:307-15. 2003..AQP5 appears to play an important role in water transfer in these glands... - Immunohistochemical characterization of the intracellular pool of water channel aquaporin-2 in the rat kidneyYuki Tajika
Department of Anatomy and Cell Biology, Gunma University School of Medicine, Showa machi, Maebashi, Gunma 371 8511, Japan
Anat Sci Int 77:189-95. 2002..Partial colocalization of AQP2 with early endosomes suggests that the endosomal system might be involved in the trafficking of AQP2... - Differential regulation of AQP2 trafficking in endosomes by microtubules and actin filamentsYuki Tajika
Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
Histochem Cell Biol 124:1-12. 2005..Altogether, our data suggest that Rab11 and microtubules maintain the proper distribution of the subapical AQP2 storage compartment, and actin filaments regulate the trafficking of AQP2 from early endosomes to the storage compartment... - Localization of the ATP-sensitive K+ channel subunit Kir6.2 in mouse pancreasM Suzuki
Laboratory of Molecular and Cellular Morphology, Institute for Molecular and Cellular Regulation, Gunma University, Japan
Diabetes 46:1440-4. 1997..2 is at the plasma membrane of islet cells. These results suggest that Kir6.2, as a component of K(ATP) channels, is an important molecule in the regulation of all the release of insulin, glucagon, and somatostatin... - Reversal of neuronal polarity characterized by conversion of dendrites into axons in neonatal rat cortical neurons in vitroK Hayashi
Department of Cell Biology, Institute for Cellular and Moleculasr Regulation, Gunma University, 3 39 15 Showamachi, Maebashi, Gunma 371 8512, Japan
Neuroscience 110:7-17. 2002..Our observations thus demonstrate in vitro a time-consuming reversal of neuronal polarity and the conversion of a dendritic cytoskeleton into an axonal one... - Direct gene transfer into rat liver cells by in vivo electroporationT Suzuki
Department of Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University, Japan
FEBS Lett 425:436-40. 1998..Estimation of the efficiency of electro-gene transfer using the fluorescence of GFP and digital analysis of microscopic images was useful to determine the optimum conditions for local gene therapy in tissues and organs... - The apical localization of SGLT1 glucose transporter is determined by the short amino acid sequence in its N-terminal domainT Suzuki
Department of Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan
Eur J Cell Biol 80:765-74. 2001..These results suggest that a short amino acid sequence of the N-terminal domain of SGLT1 plays important roles in plasma membrane targeting and specific apical localization of the protein... - Ciliogenesis and ciliary abnormalitiesH Hagiwara
Department of Anatomy and Cell Biology, Gunma University School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
Med Electron Microsc 33:109-14. 2000..Swollen cilia and the bulging type of compound cilia are formed during ciliary budding and elongation. This review also discusses the origin, composition, and function of the centriolar precursor structures... - Localization of Golgi 58K protein (formiminotransferase cyclodeaminase) to the centrosomeHaruo Hagiwara
Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine, 3 39 22, Showa machi, Maebashi, Gunma 371 8511, Japan
Histochem Cell Biol 126:251-9. 2006..FTCD in the centrosome may be associated with polyglutamylated residues of centriole microtubules and may play a role in providing centrioles with glutamate produced by cyclodeaminase domains of FTCD... - Internalization of caveolae and their relationship with endosomes in cultured human and mouse endothelial cellsTakeo Aoki
Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine, Gunma, Japan
Anat Sci Int 82:82-97. 2007..Immunogold electron microscopy revealed that internalized caveolin-1 colocalized with Rab5 or Rab4 in vesicles larger than caveolae. These results suggest that the internalized caveolae interact with early endosomes... - Aquaporins in the digestive systemToshiyuki Matsuzaki
Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
Med Electron Microsc 37:71-80. 2004..In addition, water transfer across the digestive epithelia seems to occur not only via aquaporins but also via other transporter or channel systems... - Aquaporin-2 is retrieved to the apical storage compartment via early endosomes and phosphatidylinositol 3-kinase-dependent pathwayYuki Tajika
Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
Endocrinology 145:4375-83. 2004..These results suggest that AQP2 resides in a recycling compartment at the apical side in polarized MDCK-hAQP2 cells, and its retrieval uses the apical endosomal system and the phosphatidylinositol 3-kinase-dependent pathway... - Cell biology of normal and abnormal ciliogenesis in the ciliated epitheliumHaruo Hagiwara
Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan
Int Rev Cytol 234:101-41. 2004..They have a role in determining the left-right (L-R) asymmetry of the fetus. This review also discusses the ciliogenesis of a primary cilium in the cell... - Expression and immunolocalization of water-channel aquaporins in the rat and mouse mammary glandToshiyuki Matsuzaki
Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine, Showa machi 3 39 22, Maebashi, Gunma 371 8511, Japan
Histochem Cell Biol 123:501-12. 2005..We found a similar distribution of AQP1 and AQP3 in the mouse. AQP1 and AQP3 seem to play roles in the synthesis and/or secretion of milk... 
The caudate processus hepatic vein: a boundary hepatic vein between the caudate lobe and the right liverKimitaka Kogure
Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, Japan
Ann Surg 247:288-93. 2008..This study was conducted to find the boundary vein indicating the intersegmental plane between the caudate lobe and the adjacent liver segments...- Changes of aquaporin 5-distribution during release and reaccumulation of secretory granules in isoproterenol-treated mouse parotid glandToshiyuki Matsuzaki
Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine Maebashi, Gunma 371 8511, Japan
J Electron Microsc (Tokyo) 55:183-9. 2006..AQP5 was not detected in the cytoplasm. These observations show that AQP5 does not seem to be endocytosed during the membrane recycling process following the exocytosis... - Immunohistochemical and electron microscopic observations of stromal cells in the human oviduct mucosaHaruo Hagiwara
Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma, 371 8511, Japan
Med Mol Morphol 41:221-6. 2008..These findings showed that the connective tissue-stromal cells in the human oviduct mucosa are myofibroblasts. They are considered to play an important role in the transport of oocytes by bringing about contraction of the mucosal folds... - Inhibitory neurons from fetal rat cerebral cortex exert delayed axon formation and active migration in vitroKensuke Hayashi
Department of Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University, 3 39 15 Showamachi, Maebashi, Gunma 371 8512, Japan
J Cell Sci 116:4419-28. 2003..Inhibitory neurons thus possess a more effective cytoskeletal machinery for migration than excitatory neurons and they form axons later... - Ultrastructural and immunohistochemical study of the basal apparatus of solitary cilia in the human oviduct epitheliumHaruo Hagiwara
Department of Anatomy and Cell Biology, Gunma University School of Medicine, Maebashi, Japan
J Anat 200:89-96. 2002..Although the true function of the connector is unknown as yet, it could play an important role for stabilising the basal body in the apical cytoplasm... - The primary cilia of secretory cells in the human oviduct mucosaHaruo Hagiwara
Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma, 371 8511, Japan
Med Mol Morphol 41:193-8. 2008..The basal body, the paired centriole, and the basal body-associated structures are considered to play important roles in the stabilization and fixing of the cilium in the proper position on the apical cell surface... - Depolymerization of microtubules by colcemid induces the formation of elongated and centriole-nonassociated striated rootlets in PtK(2) cellsHaruo Hagiwara
Department of Anatomy and Cell Biology, Gunma University School of Medicine, 3 39 22, Showa machi, Maebashi, Gunma 371 8511, Japan
Cell Tissue Res 309:287-92. 2002..These findings indicate functional relationships between cytoplasmic microtubules and striated rootlets and the existence of rootlet-nucleating factors in the cytoplasm, in addition to centrioles... - Aquaporins: a water channel familyToshiyuki Matsuzaki
Department of Anatomy and Cell Biology, Faculty of Medicine, Gunma University School of Medicine, Showa machi 3 39 22, Maebashi, Gunma 371 8511, Japan
Anat Sci Int 77:85-93. 2002..This review focuses on the localization of aquaporins in mammalian tissues and discusses the physiological importance of water channels... - The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granulesZhaohong Yi
Department of Molecular Medicine, Institute for Molecular and Cellular Regulation, Gunma University, 3 39 15 Showa Machi, Maebashi, Gunma 371 8512, Japan
Mol Cell Biol 22:1858-67. 2002..These results indicate that Rab27a is involved in the regulated exocytosis of conventional dense-core granules possibly through the interaction with granuphilin, in addition to its recently identified role in lysosome-related organelles... - Differential localization of aquaporin-2 and glucose transporter 4 in polarized MDCK cellsTakahiro Hasegawa
Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine, 3 39 22, Showa machi, Maebashi, Gunma 371 8511, Japan
Histochem Cell Biol 127:233-41. 2007..These results show that AQP2 and GLUT4 share a common compartment after retrieval from the plasma membrane, but their storage compartments are distinct from each other in polarized MDCK-hAQP2 cells... - Hypertonicity-induced expression of aquaporin 3 in MDCK cellsT Matsuzaki
Laboratory of Molecular and Cellular Morphology, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma 371-8512, Japan
Am J Physiol Cell Physiol 281:C55-63. 2001..These results indicate that the expression of AQP3 is upregulated by hypertonicity... - Immunolocalization of centriole-associated striated rootlets in human submandibular gland cells with and without solitary ciliaA Kano
Department of Oral and Maxillofacial Surgery, Gunma University School of Medicine, Maebashi, Japan
Histochem J 33:613-20. 2001..These observations suggest that striated rootlets may be associated with centrioles under normal physiological conditions, without formation of solitary cilia... - A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouseJ Wang
Department of Molecular Medicine, Gunma University, Maebashi, Japan
J Clin Invest 103:27-37. 1999..These findings indicate that mutant proinsulin was trapped and accumulated in the endoplasmic reticulum, which could induce beta-cell dysfunction and account for the dominant phenotype of this mutation... - Immunolocalization of water channel aquaporins in the vomeronasal organ of the rat: expression of AQP4 in neuronal sensory cellsAbduxukur Ablimit
Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
Chem Senses 33:481-8. 2008..The present findings suggest a unique water-handling feature in neuronal sensory cells in the vomeronasal organ... - Pre-embedding immunoelectron microscopy of chemically fixed mammalian tissue culture cellsHaruo Hagiwara
Department of Occupational Therapy, School of Health Sciences, Faculty of Medicine, Gunma University, Gunma, Japan
Methods Mol Biol 657:145-54. 2010..By changing the intensity of the silver enhancement, the size of the granules can be controlled. In this chapter, we described the use of Nanogold for pre-embedding immunoelectron microscopy of paraformaldehyde-fixed cultured cells... - Double-label immunoelectron microscopy for studying the colocalization of proteins in cultured cellsHaruo Hagiwara
Department of Occupational Therapy, School of Health Sciences, Faculty of Medicine, Gunma University, Gunma, Japan
Methods Mol Biol 657:249-57. 2010..In this chapter, double-label immunoelectron microscopy of gelatin-embedded cultured cells using the cryosectioning technique is described... - Immunolocalization of water channel aquaporins in the nasal olfactory mucosaAbduxukur Ablimit
Department of Anatomy and Cell Biology, Gunma University Graduate School of Medicine, Maebashi, Japan
Arch Histol Cytol 69:1-12. 2006..AQP3, AQP4, and AQP5 in the Bowman's gland may serve in the secretion to generate the microenvironment at the apical surface of the olfactory dendrites for odorant reception... - Glucose transporter GLUT3 in the rat placental barrier: a possible machinery for the transplacental transfer of glucoseB C Shin
Department of Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan
Endocrinology 138:3997-4004. 1997..The asymmetric distribution of GLUT3 across the placental barrier may suggest asymmetric transfer of glucose, which would be beneficial to provide a stable milieu for fetal development... - N-methyl-D-aspartate receptor-dependent and -independent cytotoxic effects of Dictyostelium discoideum differentiation-inducing factor-1 on rat cortical neuronsT Kanno
Laboratory of Molecular and Cellular Morphology, Institute for Molecular and Cellular Regulation, Gunma University, 3-39-15, Showamachi, Maebashi, Gunma 371-8512, Japan
Dev Growth Differ 43:709-16. 2001..These results indicate that DIF-1 induces rapid cell death via both NMDA receptor-dependent and -independent pathways in rat cortical neurons... - VAMP2 is expressed in muscle satellite cells and up-regulated during muscle regenerationYuki Tajika
Department of Neuromuscular and Developmental Anatomy, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma, 371 8511, Japan
Cell Tissue Res 328:573-81. 2007..The nature of the material transported in the VAMP2-bearing vesicles in satellite cells and myotubes is still under investigation... - Identification of a new member of type I Na/phosphate co-transporter in the rat kidneyKenichi Ishibashi
Department of Pharmacology, Jichi Medical School, Kawachi gun, Tochigi ken, Japan
Nephron Physiol 94:p10-8. 2003..To clone new phosphate transporters from the kidney... - Localization of pore-forming subunit of the ATP-sensitive K(+)-channel, Kir6.2, in rat brain neurons and glial cellsMing Zhou
Department of Anatomy, Akita University School of Medicine, Hondo 1 1 1 Akita 010 8543, Japan
Brain Res Mol Brain Res 101:23-32. 2002..2. Under the electron microscope, we showed in vivo for the first time that the immunoreactive products were localized in the endoplasmic reticulum and Golgi apparatus as well as the plasma membranes of neurons and glial cells... - Expression of aquaporin 3 (AQP3) in normal and neoplastic lung tissuesYa Lan Liu
Department of Pathology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Yamanashi 409 3898, Japan
Hum Pathol 38:171-8. 2007.... - Close relation between the inferior vena cava ligament and the caudate lobe in the human liverKimitaka Kogure
Department of General Surgical Science, Gunma University, Graduate School of Medicine, 3 39 22 Showamachi, Maebashi 371 8511, Japan
J Hepatobiliary Pancreat Surg 14:297-301. 2007..This study was conducted to clarify the real relation between the inferior vena cava (IVC) ligament and the caudate lobe in the human liver and also to elucidate their surgical importance in liver surgery... - Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubuleYoshiyuki Morishita
Department of Nephrology and Anatomy, Jichi Medical School, Tochigi, Japan
Mol Cell Biol 25:7770-9. 2005..These data demonstrate that AQP11 is essential for the proximal tubular function. AQP11-null mice are a novel model for polycystic kidney diseases and will provide a new mechanism for cystogenesis... - A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesisMotonobu Anai
Department of Internal Medicine, Institute for Adult Diseases, Asahi Life Foundation, 1 6 1, Marunouchi, Chiyoda ku, Tokyo 100 0005, Japan
J Biol Chem 280:18525-35. 2005..Furthermore, the interaction between APE and PKB, possibly dependent on the expression levels of both proteins, may be a novel molecular mechanism leading to proliferation and/or apoptosis... - Successful gene transfer using adeno-associated virus vectors into the kidney: comparison among adeno-associated virus serotype 1-5 vectors in vitro and in vivoShin Ichi Takeda
Division of Organ Replacement Research, Center for Molecular Medicine, Jichi Medical School, Tochigi, Japan
Nephron Exp Nephrol 96:e119-26. 2004..We explored the transduction efficiency of renal cells in vitro and in vivo using adeno-associated virus (AAV) serotype 1-5 vectors encoding the beta-galactosidase gene... - The glucose transporter GLUT1 and the tight junction protein occludin in nasal olfactory mucosaPiret Hussar
Department of Histology, Institute of Anatomy, Tartu University, Tartu, Estonia
Chem Senses 27:7-11. 2002..Taken together, GLUT1 and occludin may serve as part of the machinery for the specific transfer of glucose in the olfactory system while preventing the non-specific entry of substances... - Morphogenesis of an anomalous ligamentum venosum terminating in the superior left hepatic vein in a human liverKimitaka Kogure
Department of General Surgical Science (Surgery I, Graduate School of Medicine, Gunma University, 3-39-22 Showamachi, Maebashi 371-8511, Japan
J Hepatobiliary Pancreat Surg 12:310-3. 2005.... - Gap junctions mediate glucose transport between GLUT1-positive and -negative cells in the spiral limbus of the rat cochleaTatsuya Matsunami
Otolaryngology Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan
Cell Commun Adhes 13:93-102. 2006..e., that gap junctions mediate glucose transport from GLUT1-positive fibrocytes to GLUT1-negative fibrocytes in the spiral limbus...