Hitoshi Takagi

Summary

Affiliation: Gunma University
Country: Japan

Publications

  1. ncbi request reprint Zinc supplementation enhances the response to interferon therapy in patients with chronic hepatitis C
    H Takagi
    The First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Gunma, Japan
    J Viral Hepat 8:367-71. 2001
  2. ncbi request reprint Adult onset type II citrullinemia as a cause of non-alcoholic steatohepatitis
    Hitoshi Takagi
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, Showa machi 3 39, Maebashi, Gunma 371 8511, Japan
    J Hepatol 44:236-9. 2006
  3. ncbi request reprint Pilot clinical trial of the use of alpha-tocopherol for the prevention of hepatocellular carcinoma in patients with liver cirrhosis
    Hitoshi Takagi
    First Department of Internal Medicine, Gunma University Faculty of Medicine, 3 39 15, Showa Machi Maebashi, 371 8511, Japan
    Int J Vitam Nutr Res 73:411-5. 2003
  4. ncbi request reprint Living-related liver transplantation for multiple liver metastases from rectal carcinoid tumor: a case report
    Yoshimi Nakajima
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    World J Gastroenterol 12:1805-9. 2006
  5. ncbi request reprint Early diagnosis and radical surgical treatment of Budd-Chiari syndrome
    Hitoshi Takagi
    First Department of Internal Medicine, Gunma University School of Medicine, 3 39 15 Showamachi, Maebashi, Gunma 371 8511, Japan
    Hepatogastroenterology 49:1676-8. 2002
  6. ncbi request reprint Orthopedic treatment of metastatic bone fracture from hepatocellular carcinoma
    Hitoshi Takagi
    First Department of Internal Medicine, Gunma University Faculty of Medicine, 3 39 Showa machi, Maebashi, Gunma, 371 8511 Japan
    Hepatogastroenterology 49:1526-7. 2002
  7. ncbi request reprint Interstrain differences in susceptibility to non-alcoholic steatohepatitis
    Yuichi Yamazaki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    J Gastroenterol Hepatol 23:276-82. 2008
  8. ncbi request reprint Triple therapy of interferon and ribavirin with zinc supplementation for patients with chronic hepatitis C: a randomized controlled clinical trial
    Hideyuki Suzuki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi 3 39, Maebashi, Gunma 371 8511, Japan
    World J Gastroenterol 12:1265-9. 2006
  9. ncbi request reprint Hepatocellular carcinoma with portal vein tumor thrombosis: clinical characteristics, prognosis, and patient survival analysis
    Daichi Takizawa
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma, 371 8511, Japan
    Dig Dis Sci 52:3290-5. 2007
  10. ncbi request reprint Overexpression of NK2 promotes liver fibrosis in carbon tetrachloride-induced chronic liver injury
    Satoshi Hagiwara
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Liver Int 28:126-31. 2008

Detail Information

Publications90

  1. ncbi request reprint Zinc supplementation enhances the response to interferon therapy in patients with chronic hepatitis C
    H Takagi
    The First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Gunma, Japan
    J Viral Hepat 8:367-71. 2001
    ..2%). Serum zinc levels were higher in patients with IFN + Zn group than in the IFN group. Our results indicate that zinc supplementation enhances the response to interferon therapy in patients with intractable chronic hepatitis C...
  2. ncbi request reprint Adult onset type II citrullinemia as a cause of non-alcoholic steatohepatitis
    Hitoshi Takagi
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, Showa machi 3 39, Maebashi, Gunma 371 8511, Japan
    J Hepatol 44:236-9. 2006
    ..We demonstrated three male patients with CTLN2 having a liver histology of non-alcoholic steatohepatitis (NASH). Patients with NASH were analyzed for the causative gene of CTLN2, SLC25A13 and discussed...
  3. ncbi request reprint Pilot clinical trial of the use of alpha-tocopherol for the prevention of hepatocellular carcinoma in patients with liver cirrhosis
    Hitoshi Takagi
    First Department of Internal Medicine, Gunma University Faculty of Medicine, 3 39 15, Showa Machi Maebashi, 371 8511, Japan
    Int J Vitam Nutr Res 73:411-5. 2003
    ..Patients treated with alpha-tocopherol tended to live longer without development of HCC but the difference was not statistically significant...
  4. ncbi request reprint Living-related liver transplantation for multiple liver metastases from rectal carcinoid tumor: a case report
    Yoshimi Nakajima
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    World J Gastroenterol 12:1805-9. 2006
    ..Liver transplantation should be considered as a treatment option even in advanced case of carcinoid metastasis to the liver. We also discuss the literature on liver transplantation for metastatic carcinoid tumor...
  5. ncbi request reprint Early diagnosis and radical surgical treatment of Budd-Chiari syndrome
    Hitoshi Takagi
    First Department of Internal Medicine, Gunma University School of Medicine, 3 39 15 Showamachi, Maebashi, Gunma 371 8511, Japan
    Hepatogastroenterology 49:1676-8. 2002
    ..No complications were noted postoperatively and the nodular lesion in the lower extremity disappeared after surgery...
  6. ncbi request reprint Orthopedic treatment of metastatic bone fracture from hepatocellular carcinoma
    Hitoshi Takagi
    First Department of Internal Medicine, Gunma University Faculty of Medicine, 3 39 Showa machi, Maebashi, Gunma, 371 8511 Japan
    Hepatogastroenterology 49:1526-7. 2002
    ..Reconstruction by three enderpines relieved the fracture-associated pain and improved the quality of life. The patient continued to enjoy a good quality of life without pain until death by liver failure in September 2000...
  7. ncbi request reprint Interstrain differences in susceptibility to non-alcoholic steatohepatitis
    Yuichi Yamazaki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    J Gastroenterol Hepatol 23:276-82. 2008
    ..The investigation of the precise mechanism of interstrain differences may provide new means by which the pathophysiological mechanisms of NASH may be understood...
  8. ncbi request reprint Triple therapy of interferon and ribavirin with zinc supplementation for patients with chronic hepatitis C: a randomized controlled clinical trial
    Hideyuki Suzuki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi 3 39, Maebashi, Gunma 371 8511, Japan
    World J Gastroenterol 12:1265-9. 2006
    ..To study the therapeutic effect of interferon (IFN) and ribavirin with zinc supplement on patients with chronic hepatitis C viral (HCV) infection...
  9. ncbi request reprint Hepatocellular carcinoma with portal vein tumor thrombosis: clinical characteristics, prognosis, and patient survival analysis
    Daichi Takizawa
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma, 371 8511, Japan
    Dig Dis Sci 52:3290-5. 2007
    ..01). We conclude that the prognosis of HCC with PVTT was quite poor. The treatment did not improve the survival of Child C patients. As a result, the prevention, early diagnosis, and development of new treatment strategies are required...
  10. ncbi request reprint Overexpression of NK2 promotes liver fibrosis in carbon tetrachloride-induced chronic liver injury
    Satoshi Hagiwara
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Liver Int 28:126-31. 2008
    ..NK2 is a natural splice variant of HGF, but its in vivo function remains to be elucidated. We investigated the in vivo effects of NK2 on CCl4-induced liver fibrosis...
  11. ncbi request reprint Randomized controlled trial of consensus interferon with or without zinc for chronic hepatitis C patients with genotype 2
    Hideyuki Suzuki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa, Maebashi, Gunma 371 8511, Japan
    World J Gastroenterol 12:945-50. 2006
    ..This study focused on patients with genotype 2, which is more sensitive to interferon than genotype 1b, and used consensus interferon (CIFN) with or without zinc...
  12. doi request reprint A retrospective cohort study of partial splenic embolization for antiviral therapy in chronic hepatitis C with thrombocytopenia
    Hiroki Tahara
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Japan
    J Gastroenterol 46:1010-9. 2011
    ..Although partial splenic embolization (PSE) is reportedly effective prior to interferon (IFN)-based therapy, the number of subjects in these studies is small, and the appropriate candidates and disease prognosis remain unknown...
  13. doi request reprint Optimal follow-up time to determine the sustained virological response in patients with chronic hepatitis C receiving pegylated-interferon and ribavirin
    Masashi Namikawa
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    J Gastroenterol Hepatol 27:69-75. 2012
    ....
  14. ncbi request reprint Role of posterior vitreous detachment induced by intravitreal tissue plasminogen activator in macular edema with central retinal vein occlusion
    Tomoaki Murakami
    Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University, Japan
    Retina 27:1031-7. 2007
    ..To evaluate the effects of posterior vitreous detachment (PVD) in macular edema associated with central retinal vein occlusion (CRVO) treated with intravitreal tissue plasminogen activator (tPA)...
  15. doi request reprint Transforming growth factor-α attenuates hepatic fibrosis: possible involvement of matrix metalloproteinase-1
    Tatsuya Ohyama
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Liver Int 31:572-84. 2011
    ..The effect of transforming growth factor (TGF)-α on fibrosis varies between cell types and the role of TGF-α in hepatic fibrosis has not been fully elucidated...
  16. ncbi request reprint Transforming growth factor-alpha accelerates hepatocyte repopulation after hepatocyte transplantation
    Takashi Kosone
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    J Gastroenterol Hepatol 23:260-6. 2008
    ..We previously demonstrated an anti-apoptotic effect in transgenic mice overexpressing transforming growth factor (TGF)-alpha. We herein present the details of a successful hepatocyte transplantation using TGF-alpha transgenic mice...
  17. pmc The role of the nuclear receptor constitutive androstane receptor in the pathogenesis of non-alcoholic steatohepatitis
    Yuichi Yamazaki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Gut 56:565-74. 2007
    ..The pathological roles of the nuclear receptor constitutive androstane receptor (CAR), a key regulator of drug-metabolising enzymes, in the development of NASH were investigated...
  18. ncbi request reprint Overexpression of NK2 inhibits liver regeneration after partial hepatectomy in mice
    Toshiyuki Otsuka
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    World J Gastroenterol 11:7444-9. 2005
    ..To investigate the in vivo effects of NK2 on liver regeneration after partial hepatectomy (PH)...
  19. ncbi request reprint Gene expression profiles of drug-metabolizing enzymes and transporters with an overexpression of hepatocyte growth factor
    Satoru Kakizaki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Liver Int 27:109-19. 2007
    ..In this study, we investigated the gene expression profiles of such enzymes with an overexpression of hepatocyte growth factor (HGF)...
  20. ncbi request reprint Time-lapse imaging of vitreoretinal angiogenesis originating from both quiescent and mature vessels in a novel ex vivo system
    Tomoaki Murakami
    Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Invest Ophthalmol Vis Sci 47:5529-36. 2006
    ..The purpose of this study was to develop a novel ex vivo system for assessing vitreoretinal angiogenic processes that originate from both quiescent and mature vessels that could be observed with time-sequential imaging...
  21. ncbi request reprint Hepatocellular carcinoma in young adults: the clinical characteristics, prognosis, and findings of a patient survival analysis
    Yuichi Yamazaki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, 371 8511 Gunma, Japan
    Dig Dis Sci 52:1103-7. 2007
    ..Screening for HCC and an early diagnosis is needed for such patients to demonstrate an improved prognosis, especially for HBsAg-positive patients...
  22. ncbi request reprint Preventive effects of vitamin K on recurrent disease in patients with hepatocellular carcinoma arising from hepatitis C viral infection
    Satoru Kakizaki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    J Gastroenterol Hepatol 22:518-22. 2007
    ..In this study, the chemopreventive effects of vitamin K2 on the recurrence and survival of patients with HCC after curative therapy were evaluated...
  23. ncbi request reprint CCl4-induced acute liver injury in mice is inhibited by hepatocyte growth factor overexpression but stimulated by NK2 overexpression
    Toshiyuki Otsuka
    First Department of Internal Medicine, Gunma University School of Medicine, 3 39 15 Showa, Gunma 371 8511, Maebashi, Japan
    FEBS Lett 532:391-5. 2002
    ..Thus, this study indicates that HGF inhibits liver injury, and NK2 antagonizes HGF on liver injury, however, NK2 may not antagonize HGF on hepatocyte proliferation...
  24. doi request reprint Hepatocyte growth factor protects against Fas-mediated liver apoptosis in transgenic mice
    Hideyuki Suzuki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Liver Int 29:1562-8. 2009
    ..The administration of an agonistic anti-Fas antibody to mice causes massive hepatic apoptosis and fulminant hepatic failure. Several growth factors including hepatocyte growth factor (HGF) have been found to prevent apoptosis...
  25. doi request reprint Transforming growth factor-α activates pancreatic stellate cells and may be involved in matrix metalloproteinase-1 upregulation
    Hiroki Tahara
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Lab Invest 93:720-32. 2013
    ..TGF-α-induced migration of cells may be partly due to upregulation of MMP-1. TGF-α and MMP-1 upregulation may contribute to the pathogenesis of chronic pancreatitis and pancreatic cancer...
  26. ncbi request reprint Primary liver cancers with nonalcoholic steatohepatitis
    Hiroaki Hashizume
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Eur J Gastroenterol Hepatol 19:827-34. 2007
    ..Curative therapy (surgery or RFA) and weight loss by the active therapeutic intervention (nutritional care and exercise therapy) after curative therapy may help us improve the prognosis of HCC in NASH...
  27. doi request reprint Clinical characteristics and treatment for patients presenting with bleeding duodenal varices
    Satoru Kakizaki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma, Japan
    Dig Endosc 22:275-81. 2010
    ..Bleeding from ectopic varices, including duodenal varices, is uncommon, but it can be difficult to manage. The clinical data of patients diagnosed and treated for duodenal varices were reviewed to investigate the strategy for treatment...
  28. doi request reprint Respiratory effects of balloon occluded retrograde transvenous obliteration of gastric varices: a prospective controlled study
    Hirotaka Arai
    Department of Gastroenterology, Maebashi Red Cross Hospital, Maebashi, Gunma, Japan
    J Gastroenterol Hepatol 26:1389-94. 2011
    ..We evaluated the respiratory effects of balloon-occluded retrograde transvenous obliteration (BRTO) performed for the treatment of gastric varices complicating liver cirrhosis...
  29. doi request reprint Nonalcoholic fatty liver disease in Japanese patients with severe obesity who received laparoscopic Roux-en-Y gastric bypass surgery (LRYGB) in comparison to non-Japanese patients
    Satoru Kakizaki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, 371 8511, Japan
    J Gastroenterol 43:86-92. 2008
    ..This study aimed to investigate the clinical characteristics in severe obese Japanese patients undergoing laparoscopic Roux-en-Y gastric bypass surgery (LRYGB)...
  30. ncbi request reprint HGF ameliorates a high-fat diet-induced fatty liver
    Takashi Kosone
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Am J Physiol Gastrointest Liver Physiol 293:G204-10. 2007
    ..In conclusion, the data presented in this study indicated that HGF ameliorates a high-fat diet-induced fatty liver via the activation of MTP and ApoB...
  31. ncbi request reprint Hepatocellular carcinoma in extremely elderly patients: an analysis of clinical characteristics, prognosis and patient survival
    Gengo Tsukioka
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    World J Gastroenterol 12:48-53. 2006
    ..To identify the clinical and prognostic features of patients with hepatocellular carcinoma (HCC) aged 80 years or more...
  32. ncbi request reprint Hepatocyte growth factor accelerates thrombopoiesis in transgenic mice
    Takashi Kosone
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Lab Invest 87:284-91. 2007
    ..In an in vitro study, HGF induced TPO and GABP-alpha/beta expression and enhanced TPO promoter activity. Therefore, HGF induced thrombopoiesis accompanied with the overexpression of TPO through GABP stimulation...
  33. ncbi request reprint Gefitinib and gemcitabine coordinately inhibited the proliferation of cholangiocarcinoma cells
    Yoshimi Nakajima
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Anticancer Res 32:5251-62. 2012
    ..To evaluate the possibility for new therapeutic strategies, we examined the combined effect of gefitinib and gemcitabine on CCC...
  34. pmc Integrative roles of transforming growth factor-alpha in the cytoprotection mechanisms of gastric mucosal injury
    Takashi Kosone
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi 371 8511, Japan
    BMC Gastroenterol 6:22. 2006
    ..Since this TG mouse had a strong resistance to ethanol-induced gastric injury, we considered the long-term effect of TGFalpha on several gastric protection mechanisms...
  35. ncbi request reprint Lack of macrophage migration inhibitory factor protects mice against concanavalin A-induced liver injury
    Hiroaki Nakajima
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Liver Int 26:346-51. 2006
    ..Macrophage migration inhibitory factor (MIF) is involved in inflammatory and immune-mediated diseases but the role of MIF in liver injury has not yet been elucidated...
  36. ncbi request reprint Solitary mandibular metastasis as an initial manifestation of hepatocellular carcinoma
    Katsunobu Teshigawara
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    Acta Med Okayama 60:243-7. 2006
    ..The primary lesion was treated with transcatheter arterial embolization (TAE), and the metastasis to the mandible was surgically resected. The patient survived for 9 months after treatment without recurrence...
  37. ncbi request reprint Hepatic adenomatosis associated with hormone replacement therapy and hemosiderosis: a case report
    Satoshi Hagiwara
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa, Maebashi, Gunma 371 8511, Japan
    World J Gastroenterol 12:652-5. 2006
    ..Histopathological examination of the surgical specimen showed hepatic adenomatosis with hemosiderosis. Both hormone replacement therapy and iron overload could be the cause of hepatic adenomatosis...
  38. ncbi request reprint Reduction of virus burden-induced splenectomy in patients with liver cirrhosis related to hepatitis C virus infection
    Tetsuro Sekiguchi
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    World J Gastroenterol 12:2089-94. 2006
    ..To examine the hepatitis C virus (HCV) levels and immunological markers in cirrhotic patients after splenectomy...
  39. ncbi request reprint Emerging therapeutic strategies for hepatitis C virus infection
    Ken Sato
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa, Maebashi, Gunma 371 8511, Japan
    Curr Mol Pharmacol 1:130-50. 2008
    ..This review will comprehensively discuss the current treatment options and various novel antiviral reagents available. Ongoing clinical studies of promising lead drugs are also reviewed...
  40. ncbi request reprint Comparisons between the beneficial effects of different sulphonylurea treatments on ischemia-induced retinal neovascularization
    Tetsushi Kimura
    Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Free Radic Biol Med 43:454-61. 2007
    ..01). Gliclazide inhibits ischemia-induced retinal neovascularization, and this is likely to be mediated in part through the downregulation of VEGF and the suppression of oxidative stress...
  41. ncbi request reprint Novel role of erythropoietin in proliferative diabetic retinopathy
    Hitoshi Takagi
    Department of Ophthalmology and Visual Sciences, Kyoto University, Graduate School of Medicine, Japan
    Diabetes Res Clin Pract 77:S62-4. 2007
    ..Inhibition of such molecular mechanisms in the retinal angiogenesis could be a new therapeutical strategy in halting or preventing pathologic angiogenesis in diabetic retinopathy...
  42. ncbi request reprint Transforming growth factor alpha protects against Fas-mediated liver apoptosis in mice
    Daisuke Kanda
    The First Department of Internal Medicine, Gunma University School of Medicine, 3 39 15 Showa, Maebashi, Gunma 371 8511, Japan
    FEBS Lett 519:11-5. 2002
    ..Taken together, our findings suggest that TGFalpha protects against Fas-mediated liver apoptosis in vivo and up-regulation of Bcl-xL may participate in protective effect of TGFalpha...
  43. doi request reprint Elevated plasma resistin concentrations in patients with liver cirrhosis
    Satoru Kakizaki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    J Gastroenterol Hepatol 23:73-7. 2008
    ..Liver cirrhosis (LC) is characterized by an elevated number of circulating proinflammatory cytokines, hyperinsulinemia and insulin resistance. The aim of this study was to determine the plasma resistin levels in patients with LC...
  44. ncbi request reprint Gastric yolk sac tumor complicated with beta-human chorionic gonadotropin-producing metastases
    Hiroki Tahara
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi
    Intern Med 47:2145-9. 2008
    ..To avoid a misdiagnosis, careful attention should be paid to the above-mentioned morphological features and immunohistochemical findings, in addition to the clinical findings...
  45. doi request reprint Familial clustering and genetic background of primary biliary cirrhosis in Japan
    Masatoshi Yanagisawa
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Dig Dis Sci 55:2651-8. 2010
    ..Primary biliary cirrhosis (PBC) is regarded as an autoimmune liver disease and familial clustering of PBC could represent some genetic predisposition to the disease...
  46. ncbi request reprint Different outcomes of nosocomial infection with hepatitis C virus from the same origin
    Satoru Kakizaki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    World J Gastroenterol 12:659-61. 2006
    ..Although infected with the virus of the same origin, the clinical and virological courses were completely different. This suggests that host factors play a major role in conditioning the outcome of acute HCV infection...
  47. ncbi request reprint Spontaneous regression of hepatic inflammatory pseudotumor with primary biliary cirrhosis: case report and literature review
    Hiroshi Koide
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    World J Gastroenterol 12:1645-8. 2006
    ..Comparison of our case with the two previously reported cases suggests that IPT occurring with PBC does not represent the same disease entity or be a bystander for PBC...
  48. doi request reprint Primary Sjogren's syndrome complicated by bilateral pleural effusion
    Katsunobu Teshigawara
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma, Japan
    Respirology 13:155-8. 2008
    ..There was no evidence of infection, malignancy or other collagen diseases which cause pleuritis. We conclude that this case adds to the eight previously published reports of primary Sjogren's syndrome complicated by pleural effusion...
  49. ncbi request reprint Zinc is a negative regulator of hepatitis C virus RNA replication
    Kazuhisa Yuasa
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Liver Int 26:1111-8. 2006
    ..However, the role of zinc in both viral replication and the expression of viral proteins remains unclear. We aimed to clarify the effect of zinc on the replication of HCV in vitro...
  50. ncbi request reprint Elevated plasma adiponectin concentrations in patients with liver cirrhosis correlate with plasma insulin levels
    Naondo Sohara
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma 371 8511, Japan
    Liver Int 25:28-32. 2005
    ..Hypoadiponectinemia is associated with insulin-resistant diabetes and liver dysfunction. The aim of this study was to determine plasma adiponectin and insulin levels in patients with liver cirrhosis...
  51. ncbi request reprint Ruptured duodenal varices after endoscopic ligation of esophageal varices: an autopsy case
    Takashi Machida
    Department of Internal Medicine, Kiryu Welfare General Hospital, Kiryu, Gunma, Japan
    Gastrointest Endosc 63:352-4. 2006
  52. ncbi request reprint Computed tomography-guided transpulmonary radiofrequency ablation for hepatocellular carcinoma located in hepatic dome
    Mitsuo Toyoda
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    World J Gastroenterol 12:608-11. 2006
    ..To determine the feasibility of performing computed tomography (CT)-guided transpulmonary radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) located in the hepatic dome...
  53. ncbi request reprint A case of metachronous cholangiocellular and hepatocellular carcinoma with good prognosis
    Takashi Kosone
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi Gunma, 371 8511, Japan
    Hepatogastroenterology 52:1228-32. 2005
    ..Thus, even though the patient was treated with IFN, hepatitis C could progress to not only HCC but also CCC in the same patient. Our patient is still alive, 9.5 years after detection of the first tumor...
  54. ncbi request reprint Immune thrombocytopenic purpura in patients with hepatitis C virus infection
    Hiroaki Nakajima
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Hepatogastroenterology 52:1197-200. 2005
    ..The aim of this study was to clinically analyze hepatitis C virus-positive cases with immune thrombocytopenic purpura and to examine the relationship between hepatitis C virus and immune thrombocytopenic purpura...
  55. ncbi request reprint Metastasis of hepatocellular carcinoma to the supramaxillary gingiva and right ventricle
    Riki Arai
    First Department of Internal Medicine, Gunma University Faculty of Medicine, Showa, Maebashi, Japan
    Hepatogastroenterology 51:1159-61. 2004
    ..Histopathological examination showed moderately differentiated hepatocellular carcinoma of both the primary site and metastatic sites to the gingiva and the heart and poorly differentiated in the paraaortic lymph node...
  56. ncbi request reprint Intravitreal tissue plasminogen activator to treat macular edema associated with branch retinal vein occlusion
    Tomoaki Murakami
    Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Am J Ophthalmol 142:318-20. 2006
    ..To evaluate the efficacy of intravitreal tissue plasminogen activator (tPA) injection for branch retinal vein occlusion (BRVO)...
  57. ncbi request reprint Is removal of internal limiting membrane always necessary during stage 3 idiopathic macular hole surgery?
    Tetsushi Kimura
    Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Retina 25:54-8. 2005
    ..To determine the indications for internal limiting membrane (ILM) removal in stage 3 idiopathic macular holes (MHs)...
  58. ncbi request reprint Autoimmune thrombocytopenia in response to splenectomy in cirrhotic patients with accompanying hepatitis C
    Tetsuro Sekiguchi
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    World J Gastroenterol 12:1205-10. 2006
    ....
  59. ncbi request reprint Interferon-alpha-induced changes in metallothionein expression in liver biopsies from patients with chronic hepatitis C
    Takeaki Nagamine
    School of Health Science, Faculty of Medicine, Gunma University, Japan
    Can J Gastroenterol 19:481-6. 2005
    ..In addition, MT-II mRNA expression may be involved in cell proliferation in the livers of patients with chronic HCV infection...
  60. ncbi request reprint Severe manifestation of acute hepatitis A recently found in Gunma, Japan
    Daisuke Kanda
    The First Department of Internal Medicine, Gunma University School of Medicine, Showa, Maebashi, Japan
    J Gastroenterol 37:517-22. 2002
    ..We experienced an outbreak in 1998-1999, and compared the clinical features of the disease in 1998-1999 (recent outbreak) and in 1987-1988 (past outbreak) in our prefecture (Gunma)...
  61. ncbi request reprint Role of nuclear receptor CAR in carbon tetrachloride-induced hepatotoxicity
    Yuichi Yamazaki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi 371 8511, Japan
    World J Gastroenterol 11:5966-72. 2005
    ..To investigate the precise roles of CAR in CCl(4)-induced acute hepatotoxicity...
  62. ncbi request reprint Diffuse hepatic vascular malformations with right aortic arch
    Ken Sato
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa, Maebashi, Gunma 371 8511, Japan
    J Hepatol 43:1094-5. 2005
  63. ncbi request reprint [A case of autoimmune hepatitis which worsened after switching from a brand name to a generic version of prednisolone]
    Satoru Kakizaki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
    Nihon Shokakibyo Gakkai Zasshi 106:1488-93. 2009
    ..Although most generic drugs are considered to be useful, it is important to carefully observe patients to confirm that an equivalent effect is obtained after switching from a brand name to a generic drug...
  64. ncbi request reprint Long-term outcome of interferon-alpha-induced autoimmune thyroid disorders in chronic hepatitis C
    Fumina Doi
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Liver Int 25:242-6. 2005
    ..However, there are few reports regarding the long-term outcome of this complication. We aimed to evaluate the natural history of IFN-alpha-induced autoimmune thyroid disorders with long-term follow-up...
  65. doi request reprint Prolonged intrahepatic cholestasis after exposure to loxoprofen
    Takeshi Ichikawa
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Clin Ther 30:2402-6. 2008
    ..The objective of this report was to describe a case of prolonged intrahepatic cholestasis likely associated with the use of loxoprofen, a phenylpropionate NSAID...
  66. ncbi request reprint Acute pancreatitis in a patient treated with micafungin
    Ken Sato
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma, Japan
    Clin Ther 29:1468-73. 2007
    ..During 16 months of follow-up, the pancreatitis did not recur...
  67. ncbi request reprint Alcoholic chronic pancreatitis with simultaneous multiple severe complications--extrahepatic portal obliteration, obstructive jaundice and duodenal stricture
    Satoru Kakizaki
    Department of Internal Medicine, Saiseikai Maebashi Hospital, Maebashi, Gunma, Japan
    Hepatogastroenterology 52:1274-7. 2005
    ..We discussed the cause of the failure in reducing the jaundice and reviewed the previous reports of complications of pancreatitis...
  68. ncbi request reprint Small pancreatic lipoma: case report and literature review
    Ken Sato
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma, Japan
    Hepatogastroenterology 54:1582-4. 2007
    ..We also provide a brief review of the literature...
  69. ncbi request reprint Hepatocyte growth factor promotes hepatocarcinogenesis through c-Met autocrine activation and enhanced angiogenesis in transgenic mice treated with diethylnitrosamine
    Norio Horiguchi
    The First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Gunma 371 8511, Japan
    Oncogene 21:1791-9. 2002
    ..Taken together, our results suggest that HGF promotes hepatocarcinogenesis through the autocrine activation of the HGF-Met signaling pathway in association with stimulation of angiogenesis by HGF itself and/or indirectly through VEGF...
  70. doi request reprint Low burden of a JAK2-V617F mutated clone in monoclonal haematopoiesis in a Japanese woman with Budd-Chiari syndrome
    Kohtaro Toyama
    Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    Int J Hematol 89:517-22. 2009
    ..These results suggest that the JAK2-V617F mutation occurs after the onset of monoclonal haematopoiesis; thus the V617F mutation of JAK2 may not be the primary event in the induction of BCS...
  71. ncbi request reprint Fatal pneumonia caused by Burkholderia cepacia 9 months after resection of aspergilloma
    Tamotsu Ishizuka
    First Department of Internal Medicine, Gunma University School of Medicine, Showa machi, Maebashi, Japan
    Respirology 8:401-3. 2003
    ..The precise reason that this apparently immunocompetent patient developed B. cepacia pneumonia remains unknown...
  72. ncbi request reprint Potential role of the angiopoietin/tie2 system in ischemia-induced retinal neovascularization
    Hitoshi Takagi
    Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawara cho, Sakyo ku, Kyoto 606 8397, Japan
    Invest Ophthalmol Vis Sci 44:393-402. 2003
    ..In the study described herein, the role of these molecules in ischemic retinal disorders was investigated...
  73. pmc Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis
    Hideyasu Oh
    Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Kyoto University, 54 Shogoinkawara cho, Sakyo ku, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 99:383-8. 2002
    ..These results suggest that VEGF cannot only activate endothelial cells directly but also can contribute to robust angiogenesis in vivo by a mechanism that involves up-regulation of its cognate receptor expression...
  74. ncbi request reprint Efficient formation of vesicular stomatitis virus pseudotypes bearing the native forms of hepatitis C virus envelope proteins detected after sonication
    Kazushi Tamura
    Department of Virology and Preventive Medicine, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Microbes Infect 7:29-40. 2005
    ..The VSV pseudotypes developed here would be useful for analyzing the early stages of HCV infection...
  75. ncbi request reprint Type 2 diabetes mellitus complicated with smoldering myeloma and non-alcoholic steatohepatitis
    Takehiro Nakahara
    Division of Internal Medicine, Gunma University Hospital, Maebashi, Japan
    Intern Med 44:838-42. 2005
    ..To date, there are no reports of cases with DM, NASH and myeloma. Particular attention may be necessary for these complications...
  76. ncbi request reprint Concordance of ulcerative colitis in monozygotic twin sisters
    Madoka Horiya
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    World J Gastroenterol 11:7547-9. 2005
    ..Although the concordance in monozygotic twin in UC is reported to be 6.3-18.8%, the concordant case like this is relatively rare. We report this rare case of UC and the previously reported cases are also discussed...
  77. ncbi request reprint Pancreatic and gastric metastases of leiomyosarcoma arising in the left leg
    Yoshimi Nakajima
    Department of Gastroenterology, Saiseikai Maebashi Hospital, Maebashi, Japan
    Int J Clin Oncol 10:342-7. 2005
    ..In general, metastases to the pancreas and stomach are rare. We discuss the clinical and diagnostic findings of pancreatic and gastric metastases by reviewing previously reported cases...
  78. ncbi request reprint Absence of specific symptoms in chronic hepatitis C
    Motoki Iwasaki
    Isesaki Municipal Hospital, Japan
    J Gastroenterol 37:709-16. 2002
    ..No systematic research has been carried out on the symptoms of chronic hepatitis C, although the disease is believed to induce subjective symptoms such as fatigue or dullness in the legs...
  79. pmc Transcription factor Ets-1 mediates ischemia- and vascular endothelial growth factor-dependent retinal neovascularization
    Daisuke Watanabe
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Am J Pathol 164:1827-35. 2004
    ..Ets-1 up-regulation is involved in the development of retinal neovascularization, and inhibition of Ets-1 may be beneficial in the treatment of ischemic ocular diseases...
  80. ncbi request reprint [Clinical study of low-dose cisplatin and 5-fluorouracil chemotherapy via implanted fusion port in 20 patients with advanced hepatocellular carcinoma with portal vein tumor thrombosis]
    Atsushi Naganuma
    Digestive Disease Dept, Maebashi Red Cross Hospital
    Gan To Kagaku Ryoho 34:729-34. 2007
    ..We consider that treatment in such cases should be decided carefully, taking into consideration their quality of life...
  81. ncbi request reprint Hepatocellular carcinoma with peritoneal dissemination which was regressed during vitamin K2 and vitamin E administration
    Toshiyuki Otsuka
    Department of Internal Medicine, Tone Chuo Hospital, Numata
    Intern Med 46:711-5. 2007
    ..Even though this is only one case, combination therapy of vitamin K2 and E may induce growth suppression of HCC...
  82. ncbi request reprint Ectopic varices in a right diaphragm that ruptured into the pleural cavity
    Masayuki Matsui
    Department of Internal Medicine, Tone Chuo Hospital, Numata, Gunma 378 0053, Japan
    Acta Med Okayama 60:229-32. 2006
    ..Autopsy revealed a huge collateral vein in the right diaphragm. The etiology, prevalence, relationship with portal hypertension, and treatment of ectopic varices are discussed herein...
  83. ncbi request reprint [Chronic eosinophilic leukemia with symptoms resembling Budd-Chiari syndrome due to liver infiltration]
    Hirono Iriuchishima
    Department of Internal Medicine, Fujioka Public Hospital
    Rinsho Ketsueki 48:505-9. 2007
    ..As a result, the present case in which CEL occurred while demonstrating symptoms and findings similar to BCS is therefore considered to be extremely rare. Further accumulation of such cases should therefore be carried out in the future...
  84. ncbi request reprint The use of partial splenic artery embolization made it possible to administer interferon and ribavirin therapy in a liver transplant patient with fibrosing cholestatic hepatitis C complicated with thrombocytopenia
    Naondo Sohara
    Transpl Int 19:255-7. 2006
  85. ncbi request reprint Metallothionein is a potential negative regulator of apoptosis
    Ryuya Shimoda
    National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 73:294-300. 2003
    ..965). These suggest that MT may play a role in regulating apoptosis and that modulating MT expression may provide a strategy for altering cellular resistance to chemotherapeutic compounds...
  86. ncbi request reprint Randomized, double-blind, placebo-controlled trial of bovine lactoferrin in patients with chronic hepatitis C
    Hideki Ueno
    Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    Cancer Sci 97:1105-10. 2006
    ..The virologic responses were not different between two groups in any subgroup analysis. In conclusion, orally administered bLF does not demonstrate any significant efficacy in patients with chronic hepatitis C...
  87. ncbi request reprint Vascular endothelial growth factor and angiopoietin 2 expression in laser-treated choroidal neovascular membranes
    Atsushi Otani
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Retina 23:402-4. 2003
  88. ncbi request reprint Role of vitronectin receptor-type integrins and osteopontin in ischemia-induced retinal neovascularization
    Hitoshi Takagi
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Jpn J Ophthalmol 46:270-8. 2002
    ....
  89. ncbi request reprint Orthodox sometimes generates paradox
    Hitoshi Takagi
    Intern Med 44:163-4. 2005
  90. ncbi request reprint Adefovir dipivoxil monotherapy is a sufficiently effective treatment modality for Japanese patients with lamivudine-resistant chronic hepatitis B
    Ken Sato
    J Gastroenterol 41:283-5. 2006