Noriaki Sunaga

Summary

Affiliation: Gunma University
Country: Japan

Publications

  1. ncbi request reprint Contribution of the NQO1 and GSTT1 polymorphisms to lung adenocarcinoma susceptibility
    Noriaki Sunaga
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Epidemiol Biomarkers Prev 11:730-8. 2002
  2. ncbi request reprint Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer
    Noriaki Sunaga
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, 75390, USA
    Cancer Res 64:4277-85. 2004
  3. ncbi request reprint Phase II prospective study of the efficacy of gefitinib for the treatment of stage III/IV non-small cell lung cancer with EGFR mutations, irrespective of previous chemotherapy
    Noriaki Sunaga
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, and Department of Respiratory Medicine, National Nishigunma Hospital, Japan
    Lung Cancer 56:383-9. 2007
  4. ncbi request reprint Usefulness of FDG-PET for early prediction of the response to gefitinib in non-small cell lung cancer
    Noriaki Sunaga
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    Lung Cancer 59:203-10. 2008
  5. ncbi request reprint [A case of elderly non-small cell lung cancer effectively treated by combined chemotherapy of gemcitabine and S-1]
    Kyoichi Kaira
    Dept of Medicine and Molecular Science, Gunma University Graduate School of Medicine
    Gan To Kagaku Ryoho 35:1587-9. 2008
  6. pmc Oncogenic KRAS-induced interleukin-8 overexpression promotes cell growth and migration and contributes to aggressive phenotypes of non-small cell lung cancer
    Noriaki Sunaga
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma, Japan
    Int J Cancer 130:1733-44. 2012
  7. doi request reprint l-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms
    Kyoichi Kaira
    Deparmtent of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma 371 8511, Japan
    Cancer Sci 99:2380-6. 2008
  8. doi request reprint CD98 expression is associated with poor prognosis in resected non-small-cell lung cancer with lymph node metastases
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Ann Surg Oncol 16:3473-81. 2009
  9. doi request reprint L-type amino acid transporter 1 expression is a prognostic marker in patients with surgically resected stage I non-small cell lung cancer
    Hisao Imai
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma, Japan
    Histopathology 54:804-13. 2009
  10. doi request reprint Evaluation of thoracic tumors with (18)F-FMT and (18)F-FDG PET-CT: a clinicopathological study
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Int J Cancer 124:1152-60. 2009

Collaborators

Detail Information

Publications70

  1. ncbi request reprint Contribution of the NQO1 and GSTT1 polymorphisms to lung adenocarcinoma susceptibility
    Noriaki Sunaga
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Epidemiol Biomarkers Prev 11:730-8. 2002
    ..Therefore, carcinogens in tobacco smoke, which are activated by NQO1 and detoxified by GSTT1, could have a role in lung adenocarcinoma development...
  2. ncbi request reprint Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer
    Noriaki Sunaga
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, 75390, USA
    Cancer Res 64:4277-85. 2004
    ..These results suggest different roles for CAV1 in SCLC, where CAV1 acts like a tumor suppressor gene, and NSCLC, where it appears required for survival and growth...
  3. ncbi request reprint Phase II prospective study of the efficacy of gefitinib for the treatment of stage III/IV non-small cell lung cancer with EGFR mutations, irrespective of previous chemotherapy
    Noriaki Sunaga
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, and Department of Respiratory Medicine, National Nishigunma Hospital, Japan
    Lung Cancer 56:383-9. 2007
    ..The objective of this study was to prospectively evaluate the efficacy of gefitinib in patients with stage III/IV NSCLC whose tumors carried EGFR mutations, irrespective of previous chemotherapy...
  4. ncbi request reprint Usefulness of FDG-PET for early prediction of the response to gefitinib in non-small cell lung cancer
    Noriaki Sunaga
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    Lung Cancer 59:203-10. 2008
    ..The present preliminary study suggests that FDG-PET may be able to predict response to gefitinib in the early stage of therapy in patients with advanced NSCLC and may have a potential prognostic role...
  5. ncbi request reprint [A case of elderly non-small cell lung cancer effectively treated by combined chemotherapy of gemcitabine and S-1]
    Kyoichi Kaira
    Dept of Medicine and Molecular Science, Gunma University Graduate School of Medicine
    Gan To Kagaku Ryoho 35:1587-9. 2008
    ..The treatment assessment was evaluated as partial response. No toxic events were observed due to this therapy, so she was treated as an outpatient. She was considered to have good quality of life...
  6. pmc Oncogenic KRAS-induced interleukin-8 overexpression promotes cell growth and migration and contributes to aggressive phenotypes of non-small cell lung cancer
    Noriaki Sunaga
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma, Japan
    Int J Cancer 130:1733-44. 2012
    ....
  7. doi request reprint l-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms
    Kyoichi Kaira
    Deparmtent of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma 371 8511, Japan
    Cancer Sci 99:2380-6. 2008
    ..Moreover, LAT1 expression was significantly correlated with cell proliferation and angiogenesis...
  8. doi request reprint CD98 expression is associated with poor prognosis in resected non-small-cell lung cancer with lymph node metastases
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Ann Surg Oncol 16:3473-81. 2009
    ..The purpose of this study was to evaluate the prognostic value of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in resectable non-small-cell lung cancer (NSCLC) patients with N1 and N2 nodal involvement...
  9. doi request reprint L-type amino acid transporter 1 expression is a prognostic marker in patients with surgically resected stage I non-small cell lung cancer
    Hisao Imai
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma, Japan
    Histopathology 54:804-13. 2009
    ..To evaluate the prognostic value of L-type amino acid transporter 1 (LAT1) in patients with stage I non-small cell lung cancer (NSCLC)...
  10. doi request reprint Evaluation of thoracic tumors with (18)F-FMT and (18)F-FDG PET-CT: a clinicopathological study
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Int J Cancer 124:1152-60. 2009
    ..Our results suggest that coexpression of LAT1 and CD98 in addition to cell proliferation and angiogenesis is relavant for the progression and metastasis of lung cancer...
  11. doi request reprint Expression of L-type amino acid transporter 1 (LAT1) in neuroendocrine tumors of the lung
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma 371 8511, Japan
    Pathol Res Pract 204:553-61. 2008
    ..The present results suggest that LAT1 may play a significant role in cellular proliferation, lymph node metastasis, and poor outcome in patients with NE tumors of the lung...
  12. doi request reprint 18F-FMT uptake seen within primary cancer on PET helps predict outcome of non-small cell lung cancer
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma, Japan
    J Nucl Med 50:1770-6. 2009
    ..L-[3-(18)F]-alpha-methyl tyrosine ((18)F-FMT) is an amino-acid tracer for PET imaging. We evaluated the prognostic significance of (18)F-FMT PET in patients with non-small cell lung cancer...
  13. ncbi request reprint Fluorine-18-alpha-methyltyrosine positron emission tomography for diagnosis and staging of lung cancer: a clinicopathologic study
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Clin Cancer Res 13:6369-78. 2007
    ..Tumor uptake of [(18)F]FMT was compared with that of 2-[(18)F]-fluoro-2-deoxy-D-glucose ([(18)F]FDG) and correlated with L-type amino acid transporter 1 (LAT1) expression...
  14. doi request reprint Assessment of therapy response in lung cancer with ¹⁸F-α-methyl tyrosine PET
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Japan
    AJR Am J Roentgenol 195:1204-11. 2010
    ..PET with a novel tracer, L-[3-¹⁸F]-α-methyl tyrosine (¹⁸F-FMT), has been studied in lung cancer. We evaluated ¹⁸F-FMT PET for therapy response in comparison with ¹⁸F-FDG PET...
  15. doi request reprint Phase 2 study of S-1 plus carboplatin in patients with advanced non-small cell lung cancer
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma 371 8511, Japan
    Lung Cancer 68:253-7. 2010
    ..The combination of S-1 plus carboplatin is an active and well-tolerated regimen for the treatment of patients with advanced NSCLC. Further investigations are required to confirm our results in randomized trials...
  16. doi request reprint Phase I study of oral S-1 plus Cisplatin with concurrent radiotherapy for locally advanced non-small-cell lung cancer
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Int J Radiat Oncol Biol Phys 75:109-14. 2009
    ..To determine the maximum tolerated dose (MTD) and recommended dose (RD) of S-1 in combination with cisplatin and thoracic radiotherapy in patients with unresectable Stage III non-small-cell lung cancer (NSCLC)...
  17. doi request reprint Correlation of angiogenesis with 18F-FMT and 18F-FDG uptake in non-small cell lung cancer
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunman 371 8511, Japan
    Cancer Sci 100:753-8. 2009
    ..The present study demonstrated that the metabolic activity of primary tumors as evaluated by PET study with 18F-FMT and 18F-FDG is related to tumor angiogenesis and the proliferative activity in NSCLC...
  18. ncbi request reprint Epigenetic inactivation of the RAS-effector gene RASSF2 in lung cancers
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    Int J Oncol 31:169-73. 2007
    ..Our results indicate that aberrant methylation of the RASSF2 gene with the subsequent loss of RASSF2 expression plays an important role in the pathogenesis of lung cancers...
  19. ncbi request reprint Clinicopathologic significance of the mutations of the epidermal growth factor receptor gene in patients with non-small cell lung cancer
    Yoshio Tomizawa
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma, Japan
    Clin Cancer Res 11:6816-22. 2005
    ..The purpose of the present study is to gain further insights into the significance of EGFR mutation in non-small cell lung cancer (NSCLC)...
  20. doi request reprint Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in early stage squamous cell carcinoma of the lung
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma, Japan
    Cancer Sci 100:248-54. 2009
    ..A cooperative expression of LAT 1 and CD98 is a significant pathological factor for predicting the poor prognosis in patients with resectable stage I squamous cell carcinoma of the lung...
  21. ncbi request reprint A phase I dose-escalation study of S-1 plus carboplatin in patients with advanced non-small-cell lung cancer
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Japan
    Anticancer Drugs 18:471-6. 2007
    ..Objective responses were seen in four patients (response rate 33%). The combination of S-1 plus carboplatin is a feasible and well-tolerated regimen for the treatment of patients with advanced non-small-cell lung cancer...
  22. doi request reprint Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in stage I pulmonary adenocarcinoma
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma 371 8511, Japan
    Lung Cancer 66:120-6. 2009
    ..The purpose of this study was to evaluate the prognostic value of l-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in patients with stage I pulmonary adenocarcinoma...
  23. ncbi request reprint Phase I trial of oral S-1 plus gemcitabine in elderly patients with nonsmall cell lung cancer
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma 371 8511, Japan
    Anticancer Drugs 19:289-94. 2008
    ..Objective responses were seen in four patients (response rate, 42.9%). The combination of S-1 plus gemcitabine is a feasible and well-tolerated regimen for the treatment of elderly patients with advanced NSCLC...
  24. doi request reprint A phase II study of amrubicin, a synthetic 9-aminoanthracycline, in patients with previously treated lung cancer
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma 371 8511, Japan
    Lung Cancer 69:99-104. 2010
    ..This study was designed to confirm the efficacy and safety of amrubicin, a new anthracycline agent, in patients with previously treated non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC)...
  25. doi request reprint Epigenetic inactivation of the thyroid hormone receptor beta1 gene at 3p24.2 in lung cancer
    Yasuki Iwasaki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma, Japan
    Ann Surg Oncol 17:2222-8. 2010
    ..The thyroid hormone receptor beta1 (TRbeta1) gene is located at 3p24.2, where allelic loss frequently occurs in lung cancer, and aberrant TRbeta1 methylation was observed in several human cancers...
  26. ncbi request reprint A phase I dose escalation study of weekly docetaxel and carboplatin in elderly patients with nonsmall cell lung cancer
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma, Japan
    Am J Clin Oncol 30:51-6. 2007
    ....
  27. doi request reprint Comparison of L-type amino acid transporter 1 expression and L-[3-18F]-α-methyl tyrosine uptake in outcome of non-small cell lung cancer
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma 371 8511, Japan
    Nucl Med Biol 37:911-6. 2010
    ..The purpose of this study is to compare the prognostic significance of (18)F-FAMT uptake in the primary tumors with that of LAT1 expression in patients with NSCLC...
  28. doi request reprint Lung cancer producing granulocyte colony-stimulating factor and rapid spreading to peritoneal cavity
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma, Japan
    J Thorac Oncol 3:1054-5. 2008
    ..The final diagnosis obtained at autopsy demonstrated diffuse metastases spreading to peritoneal cavity resulting from G-CSF-producing lung cancer...
  29. doi request reprint L-type amino acid transporter 1 (LAT1) is frequently expressed in thymic carcinomas but is absent in thymomas
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma 371 8511, Japan
    J Surg Oncol 99:433-8. 2009
    ..We investigated the significance of LAT1 expression to evaluate malignant potential in thymic epithelial tumors...
  30. ncbi request reprint Phase I study of biweekly paclitaxel and carboplatin for frail patients with advanced non-small cell lung cancer
    Noriko Yanagitani
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Am J Clin Oncol 30:487-91. 2007
    ....
  31. ncbi request reprint Diagnostic usefulness of fluorine-18-alpha-methyltyrosine positron emission tomography in combination with 18F-fluorodeoxyglucose in sarcoidosis patients
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma 371 8511, Japan
    Chest 131:1019-27. 2007
    ..This study was conducted to investigate the usefulness of (18)F-FMT PET in combination with fluorine-18-fluorodeoxyglucose ((18)F-FDG) PET for the diagnosis of sarcoidosis in patients with suspected malignancy...
  32. pmc Knockdown of oncogenic KRAS in non-small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapy
    Noriaki Sunaga
    Hamon Center for Therapeutic Oncology Research, Simmons Cancer Center, Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Mol Cancer Ther 10:336-46. 2011
    ..Our findings suggest that targeting oncogenic KRAS by itself will not be sufficient treatment, but may offer possibilities of combining anti-KRAS strategies with other targeted drugs...
  33. ncbi request reprint Gefitinib and gemcitabine coordinately inhibited the proliferation of cholangiocarcinoma cells
    Yoshimi Nakajima
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Anticancer Res 32:5251-62. 2012
    ..To evaluate the possibility for new therapeutic strategies, we examined the combined effect of gefitinib and gemcitabine on CCC...
  34. doi request reprint Forearm muscle metastasis as an initial clinical manifestation of lung cancer
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Shouwa machi, Maebashi, Gunma, Japan
    South Med J 102:79-81. 2009
    ..Skeletal muscle metastasis as a mode of presentation of primary lung cancer is an unusual phenomenon...
  35. doi request reprint Laryngeal sarcoidosis detected by FDG positron emission tomography
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma, Japan
    Clin Nucl Med 33:878-9. 2008
    ..PET imaging demonstrated increased FDG uptake in the larynx. The histologic examination revealed laryngeal sarcoidosis. We report a case of laryngeal sarcoidosis and emphasize the role of FDG PET...
  36. ncbi request reprint Gender and age risks for hoarseness and dysphonia with use of a dry powder fluticasone propionate inhaler in asthma
    Tamotsu Ishizuka
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Allergy Asthma Proc 28:550-6. 2007
    ..In patients using ICS, especially in women and the elderly patients, who develop hoarseness/dysphonia, it is important to select the most suitable device so that patients can continue ICS therapy comfortably...
  37. ncbi request reprint Clinicopathological features of patients with bronchial-associated lymphoid tissue lymphoma
    Hisao Imai
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi
    Intern Med 48:301-6. 2009
    ..Pulmonary MALT lymphoma, also known as bronchial-associated lymphoid tissue (BALT) lymphoma, is a rare disease and the clinicopathological features have yet to be clearly elucidated...
  38. ncbi request reprint Inhibition of L-type amino acid transporter 1 has antitumor activity in non-small cell lung cancer
    Hisao Imai
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 Showa machi, Maebashi, Gunma 371 8511, Japan
    Anticancer Res 30:4819-28. 2010
    ..L-type amino acid transporter 1 (LAT1) is highly expressed in various human neoplasms. Antitumor activity of inhibiting LAT1 was analyzed in non-small cell lung cancer (NSCLC)...
  39. doi request reprint Establishment of a human lung cancer cell line with high metastatic potential to multiple organs: gene expression associated with metastatic potential in human lung cancer
    Tetsuhiro Nakano
    Department of Thoracic and Visceral Organ Surgery, Gunma University Graduate School of Medicine, Gunma 371 8511, Japan
    Oncol Rep 28:1727-35. 2012
    ..This model system may provide insights into the key genetic determinants of widespread metastasis of lung cancer...
  40. ncbi request reprint Pulmonary toxicity associated with vinorelbine-based chemotherapy in breast cancer
    Noriko Yanagitani
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Gan To Kagaku Ryoho 35:1619-21. 2008
    ..After discontinuing the above vinorelbine therapy, the patient's condition improved. We therefore diagnosed this as a case of vinorelbine-and trastuzumab-induced interstitial pneumonia...
  41. doi request reprint Primary mediastinal synovial sarcoma: a report of 2 cases
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma, Japan
    J Comput Assist Tomogr 32:238-41. 2008
    ..They were treated with radiotherapy and chemotherapy. However, there was complete obstruction of esophagus resulting from progressive diseases. The radiographic findings and treatment were discussed...
  42. ncbi request reprint Small cell carcinoma of the larynx in a long-term survivor of small-cell lung cancer
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma, Japan
    J Clin Oncol 24:2961-3. 2006
  43. ncbi request reprint Rapid growth of malignant pleural mesothelioma
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    J Thorac Oncol 2:966-7. 2007
  44. pmc Multiple lung metastases presenting as ground-glass opacities in a pulmonary adenocarcinoma: a case report
    Noriko Yanagitani
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine 3 39 15, Showa machi, Maebashi, Gunma 371 8511 Japan
    Cases J 2:6910. 2009
    ..Focal ground-glass opacity on computed tomography suggests several disorders including inflammatory disease, fibrosis, or a primary lung neoplastic lesion, metastatic lung tumor...
  45. doi request reprint B-cell non-Hodgkin lymphoma presenting as an endobronchial polypoid mass
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Shouwa machi, Maebashi, Gunma, Japan
    J Thorac Oncol 3:530-1. 2008
  46. doi request reprint Protective effect of resolvin E1 on the development of asthmatic airway inflammation
    Haruka Aoki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi 371 8511, Japan
    Biochem Biophys Res Commun 400:128-33. 2010
    ..Our results suggest that RvE1 acts on several phases of asthmatic inflammation and may have anti-inflammatory effects on various cell types...
  47. ncbi request reprint Value of FDG positron emission tomography in monitoring the effects of therapy in progressive pulmonary sarcoidosis
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Clin Nucl Med 32:114-6. 2007
  48. ncbi request reprint Serum amylase is a sensitive tumor marker for amylase-producing small cell lung cancer?
    Noriko Yanagitani
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma, 371 8511, Japan
    Int J Clin Oncol 12:231-3. 2007
    ..However, unfortunately, he died owing to deterioration of lung cancer. In this patient, the serum amylase level was found to be a highly sensitive marker of lung cancer...
  49. ncbi request reprint Genetic and epigenetic inactivation of LTF gene at 3p21.3 in lung cancers
    Hironobu Iijima
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    Int J Cancer 118:797-801. 2006
    ..In addition, we found 8 different types of nucleotide substitutions and one frameshift mutation. These results indicate that the LTF gene is inactivated by genetic and epigenetic mechanisms in lung cancer...
  50. pmc The role of [¹⁸F]fluorodeoxyglucose positron emission tomography in thymic epithelial tumors
    Kyoichi Kaira
    Division of Thoracic Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi cho, Sunto gun, Shizuoka, 411 8777, Japan
    Cancer Imaging 11:195-201. 2011
    ..Two papers reported that the degree of [18F]FDG uptake in thymic epithelial tumors is based on glucose metabolism. [18F]FDG-PET may have a further use for radiological differential diagnosis of thymomas and thymic carcinomas...
  51. doi request reprint Pulmonary traumatic pneumatocele and hematoma
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, 371 8511, Japan
    Jpn J Radiol 27:100-2. 2009
    ..Chest imaging revealed multiple pneumatoceles in bilateral lung fields. The patient was treated conservatively without surgical intervention. The pneumatocele had completely disappeared after 4 months...
  52. pmc Serum markers in interstitial pneumonia with and without Pneumocystis jirovecii colonization: a prospective study
    Yasuo Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi Gunma, Japan
    BMC Infect Dis 9:47. 2009
    ..Pneumocystis pneumonia causes interstitial changes, so making a diagnosis of PCP in patients who have interstitial pneumonia (IP) with P. jirovecii colonization is sometimes difficult based on radiography...
  53. ncbi request reprint Coinfection of invasive pulmonary aspergillosis and pneumocystis jiroveci pneumonia in a non-HIV patient
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebachi, Gunma 371 8511, Japan
    Acta Med Okayama 61:235-8. 2007
    ..Our case demonstrated that short-term systemic steroid therapy in non-HIV patients with underlying chronic lung conditions and malignancies was a risk factor for IPA and PCP, and for a combination of these infections...
  54. ncbi request reprint Interaction of radiation and gefitinib on a human lung cancer cell line with mutant EGFR gene in vitro
    Yumi Sato
    Department of Radiation Oncology, Gunma University, Graduate School of Medicine, 3 39 22, Showa machi, Maebashi, Gunma 371 8511, Japan
    Anticancer Res 32:4877-81. 2012
    ..To investigate the effect of gefitinib in combination with irradiation using HCC827 cells, a human lung cancer cell line bearing epidermal growth factor receptor (EGFR) mutation...
  55. doi request reprint Perfusion evaluation of lung cancer: assessment using dual-input perfusion computed tomography
    Sachiko Nakano
    Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Hospital, Maebashi, Gunma, Japan
    J Thorac Imaging 28:253-62. 2013
    ..The aim of this study was to investigate the feasibility of separately evaluating bronchial (BAP) and pulmonary arterial perfusion (PAP) of lung cancers using dual-input perfusion computed tomography...
  56. ncbi request reprint A proton pump inhibitor, lansoprazole, ameliorates asthma symptoms in asthmatic patients with gastroesophageal reflux disease
    Yasuo Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Tohoku J Exp Med 209:181-9. 2006
    ..0) in asthmatic patients. In conclusion, treatment with a proton pump inhibitor, lansoprazole, appears to be useful in improvement of asthma symptoms in asthmatic patients with GERD...
  57. ncbi request reprint Spontaneous regression of hepatic inflammatory pseudotumor with primary biliary cirrhosis: case report and literature review
    Hiroshi Koide
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    World J Gastroenterol 12:1645-8. 2006
    ..Comparison of our case with the two previously reported cases suggests that IPT occurring with PBC does not represent the same disease entity or be a bystander for PBC...
  58. ncbi request reprint [A case of pulmonary hypertrophic osteoarthropathy associated with primary lung cancer in a young adult successfully treated with gefitinib]
    Hisao Imai
    Department of Respiratory Medicine, The National Hospital Organization Nishi gunma Hospital
    Nihon Kokyuki Gakkai Zasshi 45:189-93. 2007
    ..After starting gefitinib and discontinuing the NSAID, She had kept a remission of rational symptom with cytoreductive effect. The abnormal findings of bone scintigrams subsequently disappeared and the patient's serum ICTP dropped...
  59. ncbi request reprint [A case of multidrug-resistant non-small cell lung cancer responding to TS-1]
    Hisao Imai
    Dept of Medicine and Molecular Science, Gunma University Graduate School of Medicine
    Gan To Kagaku Ryoho 34:221-4. 2007
    ..Chest computed tomography showed a partial response. Hematologic and non-hematologic toxicities were mild with the TS-1 administration. TS-1 could be an effective agent for treatment of multidrug-resistant non-small cell lung cancer...
  60. ncbi request reprint Increased expression and no mutation of the Flap endonuclease (FEN1) gene in human lung cancer
    Mitsuo Sato
    Department of Internal Medicine, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    Oncogene 22:7243-6. 2003
    ..Our results suggest that alterations of FEN1 are not likely to contribute to development of lung cancer...
  61. ncbi request reprint Effective combination chemotherapy of carboplatin and paclitaxel in the treatment of a recurrent small-cell lung cancer patient
    Kyoichi Kaira
    Dept of Medicine and Molecular Science, Gunma University Graduate School of Medicine
    Gan To Kagaku Ryoho 34:225-7. 2007
    ..Our result suggests that weekly chemotherapy with carboplatin and paclitaxel could be a well-tolerated and effective regimen for salvage chemotherapy of recurrent SCLC...
  62. ncbi request reprint RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cells
    Makoto Suzuki
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8593, USA
    Cancer Res 64:3137-43. 2004
    ..These results provide direct evidence that loss of DNMT1 expression abrogates tumor-associated promoter methylation and the resultant silencing of multiple genes implicated in the pathogenesis of human lung and breast cancer...
  63. ncbi request reprint Methylation and gene silencing of the Ras-related GTPase gene in lung and breast cancers
    Makoto Suzuki
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Ann Surg Oncol 14:1397-404. 2007
    ..Although loss of expression of RRAD in breast cancer cells has been reported and it may act as an oncogene, the mechanism of silencing is unknown...
  64. ncbi request reprint The 3p21 candidate tumor suppressor gene BAF180 is normally expressed in human lung cancer
    Ikuo Sekine
    Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd, Dallas, TX 75390 8593, USA
    Oncogene 24:2735-8. 2005
    ..We conclude that abnormalities of BAF180 are not frequently involved in the pathogenesis of lung cancer...
  65. ncbi request reprint Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells
    Mitsuo Sato
    Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas 75390 8593, USA
    Cancer Res 66:2116-28. 2006
    ....
  66. ncbi request reprint Silencing of HPV 18 oncoproteins With RNA interference causes growth inhibition of cervical cancer cells
    Jayanthi S Lea
    Division ofGynecologic Oncology, Hamon Center of Therapeutic Oncology Research, University ofTexas Southwestern Medical Center, Dallas, TX75390 9032, USA
    Reprod Sci 14:20-8. 2007
    ..RNA interference targeting the E7 portion of the bicistronic HPV 18 mRNA can silence both E6 and E7 oncoproteins and is most effective in cervical cancer growth inhibition...
  67. ncbi request reprint [A case of large cell neuroendocrine carcinoma in a patient with sarcoidosis]
    Noriko Yanagitani
    Department of Medicine and Molecular Science, Gunma University
    Nihon Kokyuki Gakkai Zasshi 46:574-7. 2008
    ..In sarcoidosis patients, clinicians should be alert to the possibility of concomitant malignancy...
  68. ncbi request reprint [Wnt signaling abnormalities in human lung cancer]
    Noriaki Sunaga
    Biology Division, National Cancer Center Research Institute
    Nihon Rinsho 60:733-6. 2002
  69. ncbi request reprint Differential ability of polymorphic OGG1 proteins to suppress mutagenesis induced by 8-hydroxyguanine in human cell in vivo
    Arito Yamane
    Biology Division, National Cancer Center Research Institute, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 25:1689-94. 2004
    ....
  70. ncbi request reprint Localization of a human lung adenocarcinoma susceptibility locus, possibly syntenic to the mouse Pas1 locus, in the vicinity of the D12S1034 locus on chromosome 12p11.2-p12.1
    Noriko Yanagitani
    Biology Division, National Cancer Center Research Institute, 1 1, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 23:1177-83. 2002
    ..These results indicate that the PAS1 locus is located in the vicinity of D12S1034 and a genetic variation(s) at this locus is involved in susceptibility to human lung adenocarcinoma...