Yasuo Shimizu

Summary

Affiliation: Gunma University
Country: Japan

Publications

  1. ncbi Acute impact of volcanic ash on asthma symptoms and treatment
    Y Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan
    Int J Immunopathol Pharmacol 20:9-14. 2007
  2. ncbi Proton ion-microbeam elemental analysis for inhaled particle-induced pulmonary diseases: application for diagnosis and assessment of progression
    Y Shimizu
    Department of Pulmonary Medicine, Maebashi Red Cross Hospital, 3 21 36 Asahi cho, Maebashi, Gunma 371 0014, Japan
    Curr Med Chem 20:789-93. 2013
  3. ncbi CC-chemokine CCL15 expression and possible implications for the pathogenesis of IgE-related severe asthma
    Yasuo Shimizu
    Department of Pulmonary Medicine, Maebashi Red Cross Hospital, 3 21 36 Asahi cho, Gunma, Maebashi 371 0014, Japan
    Mediators Inflamm 2012:475253. 2012
  4. ncbi [PET/CT for monitoring the therapeutic response in a patient with abdominal lymph node tuberculosis after colon cancer resection]
    Yasuo Shimizu
    Department of Respiratory Medicine, Maebashi Red Cross Hospital, 3 21 36, Asahi cho, Maebashi shi, Gunma 371 0014 Japan
    Kekkaku 87:707-12. 2012
  5. ncbi Assessment of airway inflammation by exhaled breath condensate and impedance due to gastroesophageal reflux disease (GERD)
    Yasuo Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi Showa machi, Gunma, Japan
    Inflamm Allergy Drug Targets 8:292-6. 2009
  6. ncbi High prevalence of gastroesophageal reflux disease with minimal mucosal change in asthmatic patients
    Yasuo Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan
    Tohoku J Exp Med 209:329-36. 2006
  7. ncbi Intracellular Th1/Th2 balance of pulmonary CD4(+) T cells in patients with active interstitial pneumonia evaluated by serum KL-6
    Yasuo Shimizu
    Numata National Hospital, Numata City, Gunma, Japan
    Immunopharmacol Immunotoxicol 28:295-304. 2006
  8. ncbi Proton pump inhibitor improves breath marker in moderate asthma with gastroesophageal reflux disease
    Yasuo Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma, Japan
    Respiration 74:558-64. 2007
  9. ncbi Serum markers in interstitial pneumonia with and without Pneumocystis jirovecii colonization: a prospective study
    Yasuo Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi Gunma, Japan
    BMC Infect Dis 9:47. 2009
  10. ncbi CXCR4+FOXP3+CD25+ lymphocytes accumulate in CXCL12-expressing malignant pleural mesothelioma
    Y Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi Gunma, Japan
    Int J Immunopathol Pharmacol 22:43-51. 2009

Detail Information

Publications48

  1. ncbi Acute impact of volcanic ash on asthma symptoms and treatment
    Y Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan
    Int J Immunopathol Pharmacol 20:9-14. 2007
    ....
  2. ncbi Proton ion-microbeam elemental analysis for inhaled particle-induced pulmonary diseases: application for diagnosis and assessment of progression
    Y Shimizu
    Department of Pulmonary Medicine, Maebashi Red Cross Hospital, 3 21 36 Asahi cho, Maebashi, Gunma 371 0014, Japan
    Curr Med Chem 20:789-93. 2013
    ..Elemental analysis methods like in-air micro-PIXE analysis may be useful for making precise diagnosis amd assesing disease progression to overcome threat such as occupational or environmental exposure...
  3. ncbi CC-chemokine CCL15 expression and possible implications for the pathogenesis of IgE-related severe asthma
    Yasuo Shimizu
    Department of Pulmonary Medicine, Maebashi Red Cross Hospital, 3 21 36 Asahi cho, Gunma, Maebashi 371 0014, Japan
    Mediators Inflamm 2012:475253. 2012
    ..Therefore, CCL15/CCR1 signaling could be a target for the treatment of asthma. We review the role of CCL15 in the pathogenesis of asthma and also discuss the influence of IgE-mediated immunomodulation via CCL15 and its receptor CCR1...
  4. ncbi [PET/CT for monitoring the therapeutic response in a patient with abdominal lymph node tuberculosis after colon cancer resection]
    Yasuo Shimizu
    Department of Respiratory Medicine, Maebashi Red Cross Hospital, 3 21 36, Asahi cho, Maebashi shi, Gunma 371 0014 Japan
    Kekkaku 87:707-12. 2012
    ..When it is difficult to perform invasive examinations, such as laparoscopy in case of swelling of the abdominal lymph node, 18F-FDG PET/CT can be useful for monitoring the therapeutic response of abdominal tuberculosis...
  5. ncbi Assessment of airway inflammation by exhaled breath condensate and impedance due to gastroesophageal reflux disease (GERD)
    Yasuo Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi Showa machi, Gunma, Japan
    Inflamm Allergy Drug Targets 8:292-6. 2009
    ..It is expected that treatment will be based on the latest diagnostic knowledge of GERD associated with respiratory disease and on monitoring of airway inflammation...
  6. ncbi High prevalence of gastroesophageal reflux disease with minimal mucosal change in asthmatic patients
    Yasuo Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan
    Tohoku J Exp Med 209:329-36. 2006
    ..Therefore, physicians should carefully observe asthmatic patients with minimal change on endoscopy...
  7. ncbi Intracellular Th1/Th2 balance of pulmonary CD4(+) T cells in patients with active interstitial pneumonia evaluated by serum KL-6
    Yasuo Shimizu
    Numata National Hospital, Numata City, Gunma, Japan
    Immunopharmacol Immunotoxicol 28:295-304. 2006
    ..Therefore, the Th1/Th2 profile should be investigated to determine the use of Th1/Th2 modulator therapy for active IP with elevation of KL-6...
  8. ncbi Proton pump inhibitor improves breath marker in moderate asthma with gastroesophageal reflux disease
    Yasuo Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma, Japan
    Respiration 74:558-64. 2007
    ..Gastroesophageal reflux disease (GERD) influences the symptoms of asthma with acid and oxidative stress...
  9. ncbi Serum markers in interstitial pneumonia with and without Pneumocystis jirovecii colonization: a prospective study
    Yasuo Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi Gunma, Japan
    BMC Infect Dis 9:47. 2009
    ..Pneumocystis pneumonia causes interstitial changes, so making a diagnosis of PCP in patients who have interstitial pneumonia (IP) with P. jirovecii colonization is sometimes difficult based on radiography...
  10. ncbi CXCR4+FOXP3+CD25+ lymphocytes accumulate in CXCL12-expressing malignant pleural mesothelioma
    Y Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi Gunma, Japan
    Int J Immunopathol Pharmacol 22:43-51. 2009
    ..These findings suggest that CXCL12 contributed to tumor-related inflammation by inducing the accumulation of CXCR4-expressing cells with regulatory T cell markers around MM...
  11. ncbi A proton pump inhibitor, lansoprazole, ameliorates asthma symptoms in asthmatic patients with gastroesophageal reflux disease
    Yasuo Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Tohoku J Exp Med 209:181-9. 2006
    ..0) in asthmatic patients. In conclusion, treatment with a proton pump inhibitor, lansoprazole, appears to be useful in improvement of asthma symptoms in asthmatic patients with GERD...
  12. ncbi Elemental analysis of lung tissue particles and intracellular iron content of alveolar macrophages in pulmonary alveolar proteinosis
    Yasuo Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Respir Res 12:88. 2011
    ..The iron inside alveolar macrophages was stained with Berlin blue, and its distribution was compared with that on micro-PIXE images...
  13. ncbi Decreased interstitial FOXP3(+) lymphocytes in usual interstitial pneumonia with discrepancy of CXCL12/CXCR4 axis
    Y Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Int J Immunopathol Pharmacol 23:449-61. 2010
    ..These findings suggest that the CXCL12/CXCR4 axis contributes to inflammation in UIP and f-NSIP by promoting the accumulation CXCR4(+) lymphocytes, and a decrease of Treg is correlated with the severity of fibrosis in UIP...
  14. ncbi DNA microarray genotyping of N-acetyltransferase 2 polymorphism using carbodiimide as the linker for assessment of isoniazid hepatotoxicity
    Yasuo Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Tuberculosis (Edinb) 86:374-81. 2006
    ..These findings suggest that our microarray may be clinically useful for predicting drug reactions to INH...
  15. ncbi Influence of tissue particles on Fas expression in idiopathic interstitial pneumonia
    Yasuo Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Front Biosci (Elite Ed) 3:65-73. 2011
    ..Only two IIP patients showed the co-localization of Si and Fe deposition with Fas expression. Adaptation of this method would contribute to assess the influence of particles on IIP...
  16. ncbi Changes of immunomodulatory cytokines associated with omalizumab therapy for severe persistent asthma
    Y Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    J Biol Regul Homeost Agents 25:177-86. 2011
    ..Both MIP1-δ and IL-16 decreased as asthma improved over the 4-month period of omalizumab therapy. These findings suggest that omalizumab may act via IgE-mediated immunoregulation of MIP1-δ and IL-16...
  17. ncbi Chronic exposure to particles caused bronchioloalveolar carcinoma in a patient with cryptogenic organizing pneumonia evaluated by elemental analysis
    Y Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Immunopharmacol Immunotoxicol 34:170-3. 2012
    ..The combination of COP with BAC is considered uncommon, but the risk of BAC may increase when there is a history of particle inhalation...
  18. ncbi JNK1 and JNK2 differently regulate IL-12 production in THP-1 macrophage cells
    Mitsuyoshi Utsugi
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Cytokine 51:127-31. 2010
    ....
  19. ncbi Glutathione redox regulates airway hyperresponsiveness and airway inflammation in mice
    Yoko Koike
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Am J Respir Cell Mol Biol 37:322-9. 2007
    ....
  20. ncbi PI3K p110beta positively regulates lipopolysaccharide-induced IL-12 production in human macrophages and dendritic cells and JNK1 plays a novel role
    Mitsuyoshi Utsugi
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    J Immunol 182:5225-31. 2009
    ..Our findings indicate that PI3K p110beta positively controls LPS-induced IL-12 production through the JNK1-dependent pathway in human macrophages and DCs...
  21. ncbi Glutathione redox regulates TGF-beta-induced fibrogenic effects through Smad3 activation
    Akihiro Ono
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15, Showa machi, Maebashi 371 8511, Japan
    FEBS Lett 583:357-62. 2009
    ..These data indicate that the intracellular glutathione redox status regulates TGF-beta-induced fibrogenic effects through Smad3 activation...
  22. ncbi Phase I trial of oral S-1 plus gemcitabine in elderly patients with nonsmall cell lung cancer
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma 371 8511, Japan
    Anticancer Drugs 19:289-94. 2008
    ..Objective responses were seen in four patients (response rate, 42.9%). The combination of S-1 plus gemcitabine is a feasible and well-tolerated regimen for the treatment of elderly patients with advanced NSCLC...
  23. ncbi Gender and age risks for hoarseness and dysphonia with use of a dry powder fluticasone propionate inhaler in asthma
    Tamotsu Ishizuka
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Allergy Asthma Proc 28:550-6. 2007
    ..In patients using ICS, especially in women and the elderly patients, who develop hoarseness/dysphonia, it is important to select the most suitable device so that patients can continue ICS therapy comfortably...
  24. ncbi Resolvin E1 dampens airway inflammation and hyperresponsiveness in a murine model of asthma
    Haruka Aoki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Biochem Biophys Res Commun 367:509-15. 2008
    ..These findings provide evidence that RvE1 is a pivotal counterregulatory signal in allergic inflammation and offer novel multi-pronged therapeutic approaches for human asthma...
  25. ncbi Rac1 negatively regulates lipopolysaccharide-induced IL-23 p19 expression in human macrophages and dendritic cells and NF-kappaB p65 trans activation plays a novel role
    Mitsuyoshi Utsugi
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    J Immunol 177:4550-7. 2006
    ....
  26. ncbi Rapid growth of malignant pleural mesothelioma
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    J Thorac Oncol 2:966-7. 2007
  27. ncbi C-Jun-NH2-terminal kinase mediates expression of connective tissue growth factor induced by transforming growth factor-beta1 in human lung fibroblasts
    Mitsuyoshi Utsugi
    First Department of Internal Medicine, Gunma University Faculty of Medicine, School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma, 371 8511, Japan
    Am J Respir Cell Mol Biol 28:754-61. 2003
    ..These results suggest that TGF-beta1-induced CTGF mRNA expression is mediated through the JNK-dependent pathway, whereas p38 MAP kinase and ERK pathways minimally contribute...
  28. ncbi Safety and efficacy of extracorporeal granulocyte and monocyte adsorption apheresis in patients with severe persistent bronchial asthma
    Tamotsu Ishizuka
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, 371 8511, Japan
    Inflammation 29:9-16. 2005
    ..4% after the therapy. This therapy was not harmful for patients with severe persistent asthma. A placebo-controlled study will be desired to evaluate the efficacy of this nonpharmacological strategy accurately...
  29. ncbi Multiple lung metastases presenting as ground-glass opacities in a pulmonary adenocarcinoma: a case report
    Noriko Yanagitani
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine 3 39 15, Showa machi, Maebashi, Gunma 371 8511 Japan
    Cases J 2:6910. 2009
    ..Focal ground-glass opacity on computed tomography suggests several disorders including inflammatory disease, fibrosis, or a primary lung neoplastic lesion, metastatic lung tumor...
  30. ncbi In-air microparticle induced X-ray emission analysis of particles in interstitial pneumonia lung tissue obtained by transbronchial biopsy
    Yasuo Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    J Clin Biochem Nutr 49:125-30. 2011
    ..Therefore, in the diagnosis of, elemental analysis of specimens by in-air micro-analysis could be useful for assessing exposure to particles objectively...
  31. ncbi High seroprevalence of Helicobacter pylori in chronic bronchitis among Chinese population
    Zhao Jian Jun
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan
    Tohoku J Exp Med 208:327-31. 2006
    ..This is the first report of a high seroprevalence of H. pylori infection in chronic bronchitis among Chinese population...
  32. ncbi Ambroxol inhibits platelet-derived growth factor production in human monocytic cells
    Mitsuyoshi Utsugi
    First Department of Internal Medicine, Gunma University Faculty of Medicine, School of Medicine, 3-39-15 Showa-machi, Gunma, 371-8511, Maebashi, Japan
    Eur J Pharmacol 436:47-51. 2002
    ..These findings indicate that ambroxol inhibits the lipopolysaccharide-induced PDGF production due to the suppression of p44/42 ERK activity...
  33. ncbi Pulmonary toxicity associated with vinorelbine-based chemotherapy in breast cancer
    Noriko Yanagitani
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Gan To Kagaku Ryoho 35:1619-21. 2008
    ..After discontinuing the above vinorelbine therapy, the patient's condition improved. We therefore diagnosed this as a case of vinorelbine-and trastuzumab-induced interstitial pneumonia...
  34. ncbi A phase I dose-escalation study of S-1 plus carboplatin in patients with advanced non-small-cell lung cancer
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Japan
    Anticancer Drugs 18:471-6. 2007
    ..Objective responses were seen in four patients (response rate 33%). The combination of S-1 plus carboplatin is a feasible and well-tolerated regimen for the treatment of patients with advanced non-small-cell lung cancer...
  35. ncbi Five-antituberculosis Drug-resistance Genes Detection Using Array System
    Yasuo Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    J Clin Biochem Nutr 42:228-34. 2008
    ..To minimize misunderstanding, it is necessary to confirm the number of bacilli in the sputum, and culture method is needed for comparison when use the PCR-based array system...
  36. ncbi Toll-like receptor 4 surface expression on human monocytes and B cells is modulated by IL-2 and IL-4
    Yoshinori Mita
    First Department of Internal Medicine, Faculty of Medicine, Gunma University, 3 39 15, Showa machi, Maebashi, Gunma 371 8511, Japan
    Immunol Lett 81:71-5. 2002
    ....
  37. ncbi Acute respiratory failure associated with miliary tuberculosis successfully treated with sivelestat sodium hydrate
    Mitsuyoshi Utsugi
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511
    Intern Med 45:1069-70. 2006
  38. ncbi Massive hemoptysis due to pulmonary tuberculosis
    Takeshi Hisada
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511
    Intern Med 44:156-7. 2005
  39. ncbi Small cell carcinoma of the parotid gland
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa-machi, Maebashi, Gunma, Japan
    Otolaryngol Head Neck Surg 136:330-1. 2007
  40. ncbi Different gastoroesophageal reflux symptoms of middle-aged to elderly asthma and chronic obstructive pulmonary disease (COPD) patients
    Yasuo Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    J Clin Biochem Nutr 50:169-75. 2012
    ..The presence of GERD diagnosed by the total score of FSSG influences the exacerbation of COPD. GERD symptoms differed between asthma and COPD patients, and the presence of GERD diagnosed by the FSSG influences the exacerbation of COPD...
  41. ncbi Helicobacter pylori seroprevalence in patients with mild asthma
    Zhao Jian Jun
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan
    Tohoku J Exp Med 207:287-91. 2005
    ..01). Despite the sero-epidemiological association of H. pylori infection with many inflammatory conditions, our data show no significant association between mild asthma and H. pylori infection...
  42. ncbi Glutathione redox regulates lipopolysaccharide-induced IL-12 production through p38 mitogen-activated protein kinase activation in human monocytes: role of glutathione redox in IFN-gamma priming of IL-12 production
    Mitsuyoshi Utsugi
    First Department of Internal Medicine, Faculty of Medicine, School of Medicine, Gunma University, Maebashi, Japan
    J Leukoc Biol 71:339-47. 2002
    ....
  43. ncbi Exhaled breath marker in asthma patients with gastroesophageal reflux disease
    Yasuo Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    J Clin Biochem Nutr 41:147-53. 2007
    ..Although the analysis of cooled breath has not yet been established in a clinical setting, this method is expected to provide a novel tool for monitoring airway acidification associated with GERD...
  44. ncbi [Anti-allergy drugs]
    Yasuo Shimizu
    Department of Medicine and Molecular Science, Respiration and Allergy, Gunma University Graduate School of Medicine
    Nippon Rinsho 62:419-22. 2004
  45. ncbi Cumulative incidence of childhood autism: a total population study of better accuracy and precision
    Hideo Honda
    Developmental Psychiatry Unit, Yokohama Rehabilitation Center, 1770 Toriyama cho, Kohoku Ku, Yokohama, 222 0035, Japan
    Dev Med Child Neurol 47:10-8. 2005
    ..3% and 13.7% respectively. Data on cumulative incidence of childhood autism derived from this study are the first to be drawn from an accurate, as well as precise, screening methodology...
  46. ncbi Early intervention system for preschool children with autism in the community: the DISCOVERY approach in Yokohama, Japan
    Hideo Honda
    Yokohama Rehabilitation Center, Japan
    Autism 6:239-57. 2002
    ..A clinical system based on this model has been developed in Yokohama. This system not only benefits clinical performance, but will also add significantly to research on autism...
  47. ncbi [Relationship between awareness of sexually transmitted diseases and condom use by university students: development of an awareness scale for prediction of condom use]
    Mitsuhiro Amazaki
    Graduate School of International Studies, J F Oberlin University
    Nihon Koshu Eisei Zasshi 55:306-17. 2008
    ..The purpose of this study was 1) to develop a psychological scale for preventing STDs and 2) to examine whether such an awareness scale might be used for predicting condom use by Japanese heterosexual university students...
  48. ncbi No effect of MMR withdrawal on the incidence of autism: a total population study
    Hideo Honda
    Yokohama Rehabilitation Center, Yokohama, Japan
    J Child Psychol Psychiatry 46:572-9. 2005
    ..The unique circumstances of a Japanese MMR vaccination program provide an opportunity for comparison of ASD incidence before and after termination of the program...