Shuichi Okada

Summary

Affiliation: Gunma University
Country: Japan

Publications

  1. ncbi request reprint Syntaxin 4 and Synip (syntaxin 4 interacting protein) regulate insulin secretion in the pancreatic beta HC-9 cell
    Tsugumichi Saito
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15, Showa machi, Maebashi shi, Gunma ken, 371 8511, Japan
    J Biol Chem 278:36718-25. 2003
  2. ncbi request reprint Differential activation of epidermal growth factor (EGF) receptor downstream signaling pathways by betacellulin and EGF
    Tsugumichi Saito
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma 371 8511, Japan
    Endocrinology 145:4232-43. 2004
  3. pmc Secreted nucleobindin-2 inhibits 3T3-L1 adipocyte differentiation
    Yuko Tagaya
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Protein Pept Lett 19:997-1004. 2012
  4. pmc Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles
    Eijiro Yamada
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, 371 8511, Japan
    J Cell Biol 168:921-8. 2005
  5. doi request reprint CDK5-dependent phosphorylation of the Rho family GTPase TC10(alpha) regulates insulin-stimulated GLUT4 translocation
    Shuichi Okada
    Department of Medicine, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma 371 0034, Japan
    J Biol Chem 283:35455-63. 2008
  6. ncbi request reprint Synip phosphorylation is required for insulin-stimulated Glut4 translocation
    Shuichi Okada
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15, Showa machi, Maebashi, Gunma 371 8511, Japan
    Biochem Biophys Res Commun 356:102-6. 2007
  7. ncbi request reprint Tyrosine phosphorylation of Munc18c regulates platelet-derived growth factor-stimulated glucose transporter 4 translocation in 3T3L1 adipocytes
    Mitsuhiko Umahara
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Endocrinology 149:40-9. 2008
  8. doi request reprint THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation
    Akiko Katano-Toki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Mol Endocrinol 27:769-80. 2013
  9. doi request reprint Troglitazone, a ligand of peroxisome proliferator-activated receptor-{gamma}, stabilizes NUCB2 (Nesfatin) mRNA by activating the ERK1/2 pathway: isolation and characterization of the human NUCB2 gene
    Masanobu Yamada
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Endocrinology 151:2494-503. 2010
  10. pmc Syntaxin4 interacting protein (Synip) binds phosphatidylinositol (3,4,5) triphosphate
    Tsugumichi Saito
    Department of Medicine and Molecular Science, Gunma University School of Medicine, Maebashi, Gunma, Japan
    PLoS ONE 7:e42782. 2012

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Syntaxin 4 and Synip (syntaxin 4 interacting protein) regulate insulin secretion in the pancreatic beta HC-9 cell
    Tsugumichi Saito
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15, Showa machi, Maebashi shi, Gunma ken, 371 8511, Japan
    J Biol Chem 278:36718-25. 2003
    ..These data demonstrate that syntaxin 4 plays a functional role on insulin release and granule fusion in beta cells and that this process is regulated by the syntaxin 4-specific binding protein Synip...
  2. ncbi request reprint Differential activation of epidermal growth factor (EGF) receptor downstream signaling pathways by betacellulin and EGF
    Tsugumichi Saito
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma 371 8511, Japan
    Endocrinology 145:4232-43. 2004
    ..The increased Erk activation by BTC associated with antiapoptotic function...
  3. pmc Secreted nucleobindin-2 inhibits 3T3-L1 adipocyte differentiation
    Yuko Tagaya
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Protein Pept Lett 19:997-1004. 2012
    ..Taken together, these data indicate that secreted Nucleobindin-2 is a suppressor of adipocyte differentiation through inhibition of cAMP production and insulin signal...
  4. pmc Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles
    Eijiro Yamada
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, 371 8511, Japan
    J Cell Biol 168:921-8. 2005
    ..These data demonstrate that insulin activation of Akt2 specifically regulates the docking/fusion step of GLUT4-containing vesicles at the plasma membrane through the regulation of Synip phosphorylation and Synip-Syntaxin4 interaction...
  5. doi request reprint CDK5-dependent phosphorylation of the Rho family GTPase TC10(alpha) regulates insulin-stimulated GLUT4 translocation
    Shuichi Okada
    Department of Medicine, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma 371 0034, Japan
    J Biol Chem 283:35455-63. 2008
    ..Because cortical actin reorganization is required for insulin-stimulated GLUT4 translocation, these data are consistent with a CDK5-dependent TC10alpha cycling between lipid raft and non-lipid raft compartments...
  6. ncbi request reprint Synip phosphorylation is required for insulin-stimulated Glut4 translocation
    Shuichi Okada
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15, Showa machi, Maebashi, Gunma 371 8511, Japan
    Biochem Biophys Res Commun 356:102-6. 2007
    ..These data are consistent with Synip serine 99 phosphorylation required for insulin-stimulated Glut4 translocation...
  7. ncbi request reprint Tyrosine phosphorylation of Munc18c regulates platelet-derived growth factor-stimulated glucose transporter 4 translocation in 3T3L1 adipocytes
    Mitsuhiko Umahara
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Endocrinology 149:40-9. 2008
    ..Together, these data demonstrate that one mechanism accounting for the PDGF induction of Glut4 translocation is the suppression of the Munc18c negative regulation of Syntaxin 4 function...
  8. doi request reprint THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation
    Akiko Katano-Toki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Mol Endocrinol 27:769-80. 2013
    ..These findings collectively suggest that Thrap3 could play indispensable roles in terminal differentiation of adipocytes by enhancing PPARγ-mediated gene activation cooperatively with Helz2...
  9. doi request reprint Troglitazone, a ligand of peroxisome proliferator-activated receptor-{gamma}, stabilizes NUCB2 (Nesfatin) mRNA by activating the ERK1/2 pathway: isolation and characterization of the human NUCB2 gene
    Masanobu Yamada
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Endocrinology 151:2494-503. 2010
    ....
  10. pmc Syntaxin4 interacting protein (Synip) binds phosphatidylinositol (3,4,5) triphosphate
    Tsugumichi Saito
    Department of Medicine and Molecular Science, Gunma University School of Medicine, Maebashi, Gunma, Japan
    PLoS ONE 7:e42782. 2012
    ..These data suggest that in the presence of insulin, the dissociated Synip remains anchored to the plasma membrane by binding to PIP3...
  11. doi request reprint The role of CHOP messenger RNA expression in the link between oxidative stress and apoptosis
    Yasuyo Ariyama
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    Metabolism 57:1625-35. 2008
    ..The present studies showed that CHOP should be important in pancreatic beta-cell injury by oxidative stress and indicate that CHOP may play a role in the development of pancreatic beta-cell damage on the onset of diabetes mellitus...
  12. doi request reprint Fasting concentrations of nesfatin-1 are negatively correlated with body mass index in non-obese males
    Takafumi Tsuchiya
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma, Japan Shibayagi Co Ltd, Shibukawa, Gunma, Japan
    Clin Endocrinol (Oxf) 73:484-90. 2010
    ..We recently identified a novel anorexigenic protein, nesfatin-1, which is processed from nesfatin/nucleobindin-2 (NUCB2). However, the clinical importance of this protein has not been determined...
  13. ncbi request reprint Nesfatin-1: an overview and future clinical application
    Hiroyuki Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Endocr J 56:537-43. 2009
    ..We summarize recent observations about nesfatin-1, and attempt to present future direction of nesfatin-1 research for developing a new anti-obesity treatment...
  14. doi request reprint Nucleobindin-2 is a positive modulator of EGF-dependent signals leading to enhancement of cell growth and suppression of adipocyte differentiation
    Yuko Tagaya
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Endocrinology 153:3308-19. 2012
    ..Taken together, these data indicate that nucleobindin-2 regulates EGF-stimulated MAPK kinase/Erk signaling, cell proliferation, and adipocyte differentiation...
  15. pmc NR4A1 (Nur77) mediates thyrotropin-releasing hormone-induced stimulation of transcription of the thyrotropin β gene: analysis of TRH knockout mice
    Yasuyo Nakajima
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    PLoS ONE 7:e40437. 2012
    ....
  16. doi request reprint A liver X receptor (LXR)-beta alternative splicing variant (LXRBSV) is preferentially expressed in the pituitary
    Koshi Hashimoto
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, 3 39 15 Showa machi Maebashi, Gunma 371 8511, Japan
    Biochem Biophys Res Commun 394:548-52. 2010
    ..These data provide clues to elucidating the physiological relevance of LXRBSV...
  17. doi request reprint Human stearoyl-CoA desaturase 1 (SCD-1) gene expression is negatively regulated by thyroid hormone without direct binding of thyroid hormone receptor to the gene promoter
    Koshi Hashimoto
    3 39 22 Showa machi, Maebashi, Gunma, Japan 371 8511
    Endocrinology 154:537-49. 2013
    ..In conclusion, TH negatively regulates human SCD-1 gene expression in without direct binding of the TH receptor to the SCD-1 gene promoter...
  18. doi request reprint Haploinsufficient and predominant expression of multiple endocrine neoplasia type 1 (MEN1)-related genes, MLL, p27Kip1 and p18Ink4C in endocrine organs
    Ryo Taguchi
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    Biochem Biophys Res Commun 415:378-83. 2011
    ..These findings may provide basic information for understanding the mechanisms of tissue selectivity of the tumorigenesis in patients with MEN1...
  19. pmc Nesfatin-1 induces the phosphorylation levels of cAMP response element-binding protein for intracellular signaling in a neural cell line
    Emi Ishida
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    PLoS ONE 7:e50918. 2012
    ..Our study highlights that Nesfatin-1, via its receptor, induces the phosphorylation of CREB, thus activating the intracellular signaling cascade in neurons...
  20. ncbi request reprint Glucagon plays an important role in the modification of insulin secretion by leptin
    Hiroyuki Shimizu
    Faculty of Health Care, Kiryu University, Midori, Gunma, Japan
    Islets 3:150-4. 2011
    ..The leptin effects on insulin secretion were affected by the existence of glucagon. Intracellular cyclic AMP concentrations may determine the leptin effects on insulin secretion in pancreatic β-cells...
  21. doi request reprint Thyroid hormone receptor and liver X receptor competitively up-regulate human selective Alzheimer's disease indicator-1 gene expression at the transcriptional levels
    Emi Ishida
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Biochem Biophys Res Commun 432:513-8. 2013
    ..Taken together, we concluded that TR-β and LXR-α competitively up-regulate the human Seladin-1 promoter, sharing the same response element, site A...
  22. doi request reprint Expression and mutations of KCNJ5 mRNA in Japanese patients with aldosterone-producing adenomas
    Ryo Taguchi
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    J Clin Endocrinol Metab 97:1311-9. 2012
    ..Mutations of the KCNJ5 gene have recently been identified in patients with aldosterone-producing adenomas (APA)...
  23. pmc Carbohydrate response element binding protein gene expression is positively regulated by thyroid hormone
    Koshi Hashimoto
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, 3 39 15 Showa machi Maebashi, Gunma, Japan
    Endocrinology 150:3417-24. 2009
    ..This novel observation indicates that TH fine-tunes hepatic lipogenesis via regulating SREBP-1c and ChREBP gene expression reciprocally...
  24. ncbi request reprint Identification of nesfatin-1 as a satiety molecule in the hypothalamus
    Shinsuke Oh-I
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi 371 8511, Japan
    Nature 443:709-12. 2006
    ..We identify nesfatin-1 as a satiety molecule that is associated with melanocortin signalling in the hypothalamus...
  25. doi request reprint A liver X receptor (LXR)-beta alternative splicing variant (LXRBSV) acts as an RNA co-activator of LXR-beta
    Koshi Hashimoto
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, Maebashi, Gunma 371 8511, Japan
    Biochem Biophys Res Commun 390:1260-5. 2009
    ..In the current study, we have demonstrated for the first time that an alternative splicing variant of a nuclear receptor acts as an RNA co-activator...
  26. ncbi request reprint Chop-deficient mice showed increased adiposity but no glucose intolerance
    Yasuyo Ariyama
    Department of Medicine and Molecular Science, CREST Japan Science and Technology Agency, Gunma, Japan
    Obesity (Silver Spring) 15:1647-56. 2007
    ..The study was undertaken to determine the role of CHOP in obesity in vivo...
  27. doi request reprint Cardiovascular complications of patients with aldosteronism associated with autonomous cortisol secretion
    Yasuyo Nakajima
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma 371 8511, Japan
    J Clin Endocrinol Metab 96:2512-8. 2011
    ..Primary aldosteronism (PA) is sometimes associated with the autonomous secretion of cortisol...
  28. pmc Cyclin-dependent kinase-5 is a key molecule in tumor necrosis factor-α-induced insulin resistance
    Atsushi Nohara
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Japan
    J Biol Chem 286:33457-65. 2011
    ..Together, these data demonstrate that TNF-α-mediated insulin resistance of glucose uptake can occur through a MEK/Erk-dependent activation of CDK5...
  29. ncbi request reprint A new anorexigenic protein, nesfatin-1
    Hiroyuki Shimizu
    aDepartment of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Peptides 30:995-8. 2009
    ..In this review, we summarized recent progress in the research about the possible mechanism of nesfatin-1-induced anorexia...
  30. pmc Crosstalk between thyroid hormone receptor and liver X receptor in the regulation of selective Alzheimer's disease indicator-1 gene expression
    Emi Ishida
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    PLoS ONE 8:e54901. 2013
    ..Taking these findings together, we concluded that TH up-regulates Seladin-1 gene expression at the transcriptional level and LXR-α maintains the gene expression...
  31. ncbi request reprint Leptin resistance and obesity
    Hiroyuki Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Endocr J 54:17-26. 2007
  32. doi request reprint Incidence of β3-adrenergic receptor polymorphism and prediction of successful weight reduction with mazindol therapy in severely obese Japanese subjects
    Hiroyuki Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371, Japan Electronic
    Obes Res Clin Pract 1:I-II. 2007
    ..Thus the ADRB3 gene polymorphism is predictive for difficulty in weight reduction with mazindol treatment, but is not related to the development of severe obesity in the Japanese population.: ..
  33. ncbi request reprint Contribution of fasting and postprandial hyperglycemia to hemoglobin A1c in insulin-treated Japanese diabetic patients
    Hiroyuki Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Endocr J 55:753-6. 2008
    ..Postprandial hyperglycemia after breakfast and dinner should be regarded as most important for improving HbA(1c) levels in insulin treated diabetic patients...
  34. ncbi request reprint Fenofibrate, troglitazone, and 15-deoxy-Delta12,14-prostaglandin J2 close KATP channels and induce insulin secretion
    Kenju Shimomura
    Department of Medicine and Molecular Science, Gunma University School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma, 371 8511 Japan
    J Pharmacol Exp Ther 310:1273-80. 2004
    ..Our data suggest that PPAR-alpha and -gamma ligands interact directly with the beta-cell membrane and stimulate insulin secretion...
  35. ncbi request reprint Discovery of nesfatin-1 and overview of biological actions and new developments
    Masatomo Mori
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi 371 8511, Japan
    Curr Pharm Des 19:6921-8. 2013
    ..We discuss what is currently known about nesfatin-1, including new developments in our understanding of its distribution, regulation, and biological function. ..
  36. pmc Aberrant histone modifications at the thyrotropin-releasing hormone gene in resistance to thyroid hormone: analysis of F455S mutant thyroid hormone receptor
    Ryohei Umezawa
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Endocrinology 150:3425-32. 2009
    ....
  37. ncbi request reprint Molecular mechanisms associated with leptin resistance: n-3 polyunsaturated fatty acids induce alterations in the tight junction of the brain
    Shinsuke Oh-I
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi 371 8511, Gunma, Japan
    Cell Metab 1:331-41. 2005
    ..We conclude that n-3 PUFA induces peripheral leptin resistance via an increase in the expression of hypothalamic occludin, reducing paracellular transport of leptin into the brain...
  38. ncbi request reprint Loss of consciousness and hypokalemia in an elderly man with a mutation of the thiazide-sensitive Na-Cl cotransporter gene
    Tetsu Hashida
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Endocr J 53:859-63. 2006
    ..Therefore, the mutation found in this patient may be responsible for Gitelman's syndrome...
  39. ncbi request reprint 9HODE stimulates cell proliferation and extracellular matrix synthesis in human mesangial cells via PPARgamma
    Mayumi Negishi
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 22 Showamachi, Maebashi, Gunma 371 8511, Japan E mail
    Exp Biol Med (Maywood) 229:1053-60. 2004
    ..In addition, the stimulatory effects are, at least in part, mediated by PPARgamma, which may exist in downstream of ERK1/2 pathway...
  40. ncbi request reprint [Hypertension associated with hyperthyroidism and hypothyroidism]
    Shuichi Okada
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
    Nihon Rinsho 62:512-6. 2004
  41. ncbi request reprint Primary bilateral adrenal diffuse large B-cell lymphoma demonstrating adrenal failure
    Kazuhiko Horiguchi
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, Maebashi
    Intern Med 49:2241-6. 2010
    ..We concluded that PAL should be considered as a possible cause of bilateral adrenal incidentalomas with progressive adrenal insufficiency...
  42. ncbi request reprint Cumulative effects of genetic risk variants on the development of common atherosclerosis
    Takafumi Tsuchiya
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15, Showa, Maebashi, Gunma 371 8511, Japan
    Expert Rev Cardiovasc Ther 9:295-8. 2011
    ..The findings of this study may indicate a new biochemical pathway involved in the development of atherosclerosis...
  43. ncbi request reprint Glucose-dependent insulinotropic polypeptide induced growth hormone secretion in acromegaly
    Mitsuhiko Umahara
    Public Nanokaichi Hospital, Department of Internal Medicine, Tomioka shi, Gunma, Japan
    Endocr J 50:643-50. 2003
    ..These data suggested that some somatotroph adenoma cells have an aberrant response to GIP which may go toward explaining paradoxical GH secretions to OGTT in acromegalics...
  44. ncbi request reprint Enteropathy-type T-cell lymphoma that was pathologically diagnosed as celiac disease
    Hidetoshi Yasuoka
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, Maebashi
    Intern Med 46:1219-24. 2007
    ..In light of the histological findings, we concluded that this was a case of ETL associated with celiac disease, which is extremely rare in Japan...
  45. ncbi request reprint Acute thrombocytopenia associated with preexisting ulcerative colitis successfully treated with colectomy
    Takeshi Hisada
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi
    Intern Med 45:87-91. 2006
    ..In this situation, colectomy might cure both UC and resistant thrombocytopenia. Steroid-refractory and life-threatening UC complicated by thrombocytopenia presumably caused by ITP is therefore a possible indication for colectomy...
  46. ncbi request reprint Introduction of DNA into 3T3-L1 adipocytes by electroporation
    Shuichi Okada
    First Department of Internal Medicine, Gunma University School of Medicine, Japan
    Methods Mol Med 83:93-6. 2003
  47. pmc Entry of newly synthesized GLUT4 into the insulin-responsive storage compartment is GGA dependent
    Robert T Watson
    Department of Pharmacological Sciences, SUNY Stony Brook, Stony Brook, NY 11794 8651, USA
    EMBO J 23:2059-70. 2004
    ..Together, these data demonstrate that following biosynthesis, GLUT4 directly sorts and traffics to the insulin-responsive storage compartment through a specific GGA-sensitive process...
  48. ncbi request reprint Phosphodiesterase 3 (PDE3) attenuates insulin secretion from the human pancreas: a specific PDE3 inhibitor improves insulin secretion in type II diabetes mellitus
    Shuichi Okada
    Endocr J 49:581-2. 2002