S Ohwada

Summary

Affiliation: Gunma University
Country: Japan

Publications

  1. ncbi Omentoplasty versus no omentoplasty for cervical esophagogastrostomy following radical esophagectomy
    Susumu Ohwada
    Second Department of Surgery, Gunma University Faculty of Medicine, 3 39 15 Showa Machi, Maebashi 371 8511, Japan
    Hepatogastroenterology 49:181-4. 2002
  2. ncbi Omentoplasty for cervical esophagogastrostomy following radical esophagectomy with three-field dissection
    S Ohwada
    Second Department of Surgery, Gunma University School of Medicine, Japan
    Hepatogastroenterology 47:1305-9. 2000
  3. ncbi Surgical outcome of stage III and IV adrenocortical carcinoma
    Susumu Ohwada
    Department of Surgery, Gunma University School of Medicine, 3Maebashi, Gunma, Japan
    Jpn J Clin Oncol 37:108-13. 2007
  4. ncbi Low-dose erythromycin reduces delayed gastric emptying and improves gastric motility after Billroth I pylorus-preserving pancreaticoduodenectomy
    S Ohwada
    Second Department of Surgery, Gunma University Faculty of Medicine, Maebashi, Japan
    Ann Surg 234:668-74. 2001
  5. ncbi Preoperative tegafur suppositories for resectable rectal cancer: phase II trial
    Susumu Ohwada
    Gunma Oncology Study Group, and Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi 371 8511, Gunma, Japan
    Dis Colon Rectum 49:1602-10. 2006
  6. ncbi Ventral pancreas-preserving pancreatic head and body resection
    S Ohwada
    Second Department of Surgery, Gunma University Faculty of Medicine, 3 39 15 Showa Machi, Maebashi 371 8511, Japan
    Hepatogastroenterology 48:1622-4. 2001
  7. ncbi Beneficial effects of protein-bound polysaccharide K plus tegafur/uracil in patients with stage II or III colorectal cancer: analysis of immunological parameters
    Susumu Ohwada
    Gunma Oncology Study Group, Gunma University, Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    Oncol Rep 15:861-8. 2006
  8. ncbi In situ vs ex situ pancreatic duct stents of duct-to-mucosa pancreaticojejunostomy after pancreaticoduodenectomy with billroth I-type reconstruction
    Susumu Ohwada
    Second Department of Surgery, Gunma University Faculty of Medicine, 3 39 15 Showa Machi, Maebashi, Japan
    Arch Surg 137:1289-93. 2002
  9. ncbi Perioperative real-time monitoring of indocyanine green clearance by pulse spectrophotometry predicts remnant liver functional reserve in resection of hepatocellular carcinoma
    S Ohwada
    Department of Surgery, Graduate School of Medicine, Gunma University, 3 39 15 Showa Machi, Maebashi 371 8511, Japan
    Br J Surg 93:339-46. 2006
  10. ncbi Intraoperative massive pulmonary tumor embolism from clear cell sarcoma in the retroperitoneum: successful treatment using cardiopulmonary bypass
    Susumu Ohwada
    Second Department of Surgery, Gunma University Faculty of Medicine, Maebashi, Japan
    Hepatogastroenterology 51:987-9. 2004

Collaborators

Detail Information

Publications92

  1. ncbi Omentoplasty versus no omentoplasty for cervical esophagogastrostomy following radical esophagectomy
    Susumu Ohwada
    Second Department of Surgery, Gunma University Faculty of Medicine, 3 39 15 Showa Machi, Maebashi 371 8511, Japan
    Hepatogastroenterology 49:181-4. 2002
    ..Omentoplasty--wrapping the omentum around the alimentary tract anastomosis is thought to lower the rate of anastomotic leakage. We evaluated the role of omentoplasty to reinforce cervical esophagogastrostomy after radical esophagectomy...
  2. ncbi Omentoplasty for cervical esophagogastrostomy following radical esophagectomy with three-field dissection
    S Ohwada
    Second Department of Surgery, Gunma University School of Medicine, Japan
    Hepatogastroenterology 47:1305-9. 2000
    ....
  3. ncbi Surgical outcome of stage III and IV adrenocortical carcinoma
    Susumu Ohwada
    Department of Surgery, Gunma University School of Medicine, 3Maebashi, Gunma, Japan
    Jpn J Clin Oncol 37:108-13. 2007
    ..Adrenocortical carcinoma (ACC) is a rare tumor usually diagnosed at an advanced stage on invasion of or adherence to adjacent organs. We report surgical outcome of stage III and IV ACCs...
  4. ncbi Low-dose erythromycin reduces delayed gastric emptying and improves gastric motility after Billroth I pylorus-preserving pancreaticoduodenectomy
    S Ohwada
    Second Department of Surgery, Gunma University Faculty of Medicine, Maebashi, Japan
    Ann Surg 234:668-74. 2001
    ....
  5. ncbi Preoperative tegafur suppositories for resectable rectal cancer: phase II trial
    Susumu Ohwada
    Gunma Oncology Study Group, and Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi 371 8511, Gunma, Japan
    Dis Colon Rectum 49:1602-10. 2006
    ..A simpler, safer, and more convenient treatment would be preferable. Preoperative tegafur suppositories (1,500 mg/day) for at least 14 days were piloted...
  6. ncbi Ventral pancreas-preserving pancreatic head and body resection
    S Ohwada
    Second Department of Surgery, Gunma University Faculty of Medicine, 3 39 15 Showa Machi, Maebashi 371 8511, Japan
    Hepatogastroenterology 48:1622-4. 2001
    ..The patient is well now two years after surgery. A new limited pancreatic resection, ventral pancreas-preserving pancreatic head and body resection, was safely applied to a huge mucinous cystic neoplasm of the pancreas...
  7. ncbi Beneficial effects of protein-bound polysaccharide K plus tegafur/uracil in patients with stage II or III colorectal cancer: analysis of immunological parameters
    Susumu Ohwada
    Gunma Oncology Study Group, Gunma University, Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    Oncol Rep 15:861-8. 2006
    ..Pre-operative serum IAP values <or=500 microg ml(-1) and an NK cell population >or=8% at 3 months after surgery are possible PSK response predictors...
  8. ncbi In situ vs ex situ pancreatic duct stents of duct-to-mucosa pancreaticojejunostomy after pancreaticoduodenectomy with billroth I-type reconstruction
    Susumu Ohwada
    Second Department of Surgery, Gunma University Faculty of Medicine, 3 39 15 Showa Machi, Maebashi, Japan
    Arch Surg 137:1289-93. 2002
    ..Pancreatic fistula is a leading cause of morbidity and mortality after pancreaticoduodenectomy, and an external stent of pancreaticojejunostomy has been recommended to prevent pancreatic fistula...
  9. ncbi Perioperative real-time monitoring of indocyanine green clearance by pulse spectrophotometry predicts remnant liver functional reserve in resection of hepatocellular carcinoma
    S Ohwada
    Department of Surgery, Graduate School of Medicine, Gunma University, 3 39 15 Showa Machi, Maebashi 371 8511, Japan
    Br J Surg 93:339-46. 2006
    ..There is no standard method for predicting remnant liver functional reserve after hepatectomy or for monitoring it in real time...
  10. ncbi Intraoperative massive pulmonary tumor embolism from clear cell sarcoma in the retroperitoneum: successful treatment using cardiopulmonary bypass
    Susumu Ohwada
    Second Department of Surgery, Gunma University Faculty of Medicine, Maebashi, Japan
    Hepatogastroenterology 51:987-9. 2004
    ..Safe prevention measures should be accomplished as a part of the perioperative management of patients with inferior vena cava tumor thrombus that may be fragile, and cardiopulmonary bypass should always be stand-by on surgery...
  11. ncbi Adjuvant immunochemotherapy with oral Tegafur/Uracil plus PSK in patients with stage II or III colorectal cancer: a randomised controlled study
    S Ohwada
    Department of Surgery, Gunma University, Graduate School of Medicine, Gunma Oncology Study Group GOSG, 3 39 15 Showa Machi, Maebashi 371 8511, Gunma, Japan
    Br J Cancer 90:1003-10. 2004
    ..017-19.014; P=0.047) were each significant indicators of recurrence. Adverse effects were mild and compliance was good. Oral PSK with UFT reduced recurrence in stage II and III colorectal cancer, and increased survival in stage III...
  12. ncbi Advantages of Celsior solution in graft preservation from non-heart-beating donors in a canine liver transplantation model
    Susumu Ohwada
    Second Department of Surgery, Gunma University Faculty of Medicine, 3 39 15 Showa Machi, Maebashi, 371 8511, Japan
    J Surg Res 102:71-6. 2002
    ..We compared the Celsior solution, a new extracellular-type, low-potassium, low-viscosity preservation solution, with the University of Wisconsin (UW) solution in a canine orthotopic liver transplantation from NHBD...
  13. ncbi The effect of cyclooxygenase-2 inhibitor FK3311 on ischemia-reperfusion injury in a canine total hepatic vascular exclusion model
    Y Sunose
    Second Department of Surgery, Gunma University School of Medicine, Maebashi, Japan
    J Am Coll Surg 192:54-62. 2001
    ..05) in the FK group, and 6-keto-PGF1alpha was not significantly lower. CONCLUSIONS: FK protected against hepatic warm ischemia-reperfusion injury by marked inhibition of TxA2...
  14. ncbi The effect of a selective cyclooxygenase-2 inhibitor in extended liver resection with ischemia in dogs
    I Takeyoshi
    Second Department of Surgery, Gunma University School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma, 371-8511, Japan
    J Surg Res 100:25-31. 2001
    ..CONCLUSIONS: FK3311 ameliorates the ischemia-reperfusion injury caused by Pringle's procedure during extensive liver resection. This agent may be clinically useful in extended liver surgery involving vascular isolation...
  15. ncbi Effects of FK3311 on pulmonary ischemia-reperfusion injury in a canine model
    Y Sunose
    Second Department of Surgery, Gunma University School of Medicine, 3-39-15 Showa-machi, Gunma, Maebashi, 371-8511, Japan
    J Surg Res 95:167-73. 2001
    ..05) reduced. Two-day survival rate was significantly (P < 0.05) better in the FK group than in the control group. CONCLUSIONS: FK has protective effects on pulmonary I/R injury stemming from marked inhibition of TxA(2)...
  16. ncbi Effects of a p38 mitogen-activated protein kinase inhibitor as an additive to university of wisconsin solution on reperfusion injury in liver transplantation
    D Yoshinari
    Second Department of Surgery, Gunna University School of Medicine, Japan
    Transplantation 72:22-7. 2001
    ..These results suggest that inhibiting the activation of p38 MAPK may attenuate ischemia/reperfusion injury in liver transplantation...
  17. ncbi Effects of 5'-DFUR and OK-432 on cytokines and thymidine phosphorylase in tumor tissue of gastric cancer patients
    S Ohwada
    Second Department of Surgery, Gunma University School of Medicine, Japan
    Anticancer Res 17:2313-8. 1997
    ..The purpose of the study was to verify whether OK-432 in combination with 5'-DFUR induced thymidine phosphorylase (TdR Pase) and cytokines in gastric cancer patients as well as in vitro...
  18. ncbi Effects of transfusion on gastrointestinal anastomotic wound healing and leukocyte function in rats
    S Ohwada
    Second Department of Surgery, Faculty of Medicine, Gunma University, Maebashi, Japan
    Eur Surg Res 32:353-8. 2000
    ..This study was done to investigate the effects of blood transfusion on gastrointestinal anastomotic wound healing and leukocyte function...
  19. ncbi Effects of a dual inhibitor of tumor necrosis factor-alpha and interleukin-1 on lipopolysaccharide-induced lung injury in rats: involvement of the p38 mitogen-activated protein kinase pathway
    D Yoshinari
    Second Department of Surgery, Gunma University School of Medicine, Maebashi, Japan
    Crit Care Med 29:628-34. 2001
    ..The mechanism responsible for the decreased TNF-alpha and IL-1 may be related to the inhibitory effect of FR167653 on p38 MAP kinase activation...
  20. ncbi FR128998 ameliorates liver injury in extended liver resection with ischemia in dogs
    S Iwazaki
    Second Department of Surgery, Gunma University School of Medicine, Maebashi, Gunma, Japan
    Hepatogastroenterology 48:197-202. 2001
    ..05) better in the FR-treated group than in the control group. CONCLUSIONS: FR128998 provides a protective effect for liver parenchyma and sinusoidal endothelial cells during extended liver resection with ischemia...
  21. ncbi Segmental gastrectomy for early cancer in the mid-stomach
    S Ohwada
    Second Department of Surgery, Gunma University School of Medicine, Showa machi, Japan
    Hepatogastroenterology 46:1229-33. 1999
    ..We modified the surgical procedure for segmental gastrectomy, which is normally used for peptic ulcers, to treat early gastric cancer of the mid-stomach. In this paper, we describe the surgical technique and its results...
  22. ncbi Gastric emptying after segmental gastrectomy for early cancer in the middle part of the stomach
    S Ohwada
    The Second Department of Surgery, Gunma University School of Medicine, Maebashi, Japan
    Hepatogastroenterology 46:2081-5. 1999
    ..We evaluated the quality of life and gastric emptying in patients who had undergone a segmental gastrectomy to treat early gastric cancer in the middle part of the stomach...
  23. ncbi Glutaraldehyde-fixed heterologous pericardium for vena cava grafting following hepatectomy
    S Ohwada
    Second Department of Surgery, Gunma University School of Medicine, Japan
    Hepatogastroenterology 46:855-8. 1999
    ..Glutaraldehyde-fixed heterologous pericardium has been widely used for grafts in cardiac surgery. We applied it for inferior vena cava (IVC) patch grafting following combined resection of the liver and the IVC...
  24. ncbi Extended hepatectomy with ePTFE graft vena caval replacement and hepatic vein reconstruction: a case report
    S Ohwada
    Second Department of Surgery, Gunma University School of Medicine, Japan
    Hepatogastroenterology 46:1151-5. 1999
    ..Twenty-one months after surgery, the patient is in good condition without recurrence of tumor...
  25. ncbi Novel nitric oxide donor (FK409) ameliorates liver damage during extended liver resection with warm ischemia in dogs
    M Aiba
    Second Department of Surgery, Gunma University School of Medicine, Maebashi, Japan
    J Am Coll Surg 193:264-71. 2001
    ..The 3-day survival rate was statistically better in the FK409 group (67%) than in the control group (14%). CONCLUSIONS: FK409 appears to have protective effects during extended liver resection with ischemia...
  26. ncbi A spontaneous nitric oxide donor ameliorates small bowel ischemia-reperfusion injury in dogs
    K Kawata
    Second Department of Surgery, Gunma University School of Medicine, Maebashi, Japan
    Dig Dis Sci 46:1748-56. 2001
    ..The serum NO levels were significantly higher in the FK group than in the control group during FK administration. FK409 has protective effects on ischemia-reperfusion injury of the small intestine due to NO release...
  27. ncbi Effects of a phosphate buffered extracellular (Ep4) solution in preservation and reperfusion injury in the canine liver
    Y Kawashima
    The Second Department of Surgery, Gunma University School of Medicine, Maebashi, Japan
    Tohoku J Exp Med 187:99-110. 1999
    ..The present study suggests that the liver can be stored better for a longer time using Ep4 solution than using LR and CM solutions...
  28. ncbi Left colon substitution with His' angle following total gastrectomy. Surgical technique using stapling devices
    S Ohwada
    Second Department of Surgery, Gunma University School of Medicine, Maebashi, Gunma, Japan
    Dig Surg 16:12-5. 1999
    ..Barium radiograms of the interposed colon segment showed that the capacity and passage of the interposed colon were adequate, and regurgitation did not occur. Diet volume was satisfactory and weight loss minimal...
  29. ncbi Results of duct-to-mucosa pancreaticojejunostomy for pancreaticoduodenectomy Billroth I type reconstruction in 100 consecutive patients
    S Ohwada
    Second Department of Surgery, Gunma University Faculty of Medicine, Maebashi, Japan
    J Am Coll Surg 193:29-35. 2001
    ..3%). CONCLUSIONS: A simple continuous running suture and parachuting for duct-to-mucosal pancreaticojejunostomy makes pancreaticoduodenectomy a safe procedure, even in a Billroth I type reconstruction...
  30. ncbi Metastasis and invasion of hepatocellular carcinoma mimicking a right adrenal tumor
    S Ohwada
    Second Department of Surgery, Gunma University School of Medicine, Maebashi, Japan
    Hepatogastroenterology 45:1104-10. 1998
    ....
  31. ncbi Hepatic vein reconstruction at inferior vena cava confluence using left renal vein graft
    S Ohwada
    Second Department of Surgery, Gunma University School of Medicine, Japan
    Hepatogastroenterology 45:1833-6. 1998
    ....
  32. ncbi Gonadal vein graft for hepatic artery reconstruction
    S Ohwada
    The Second Department of Surgery, Gunma University School of Medicine, Maebashi, Japan
    Hepatogastroenterology 46:1823-6. 1999
    ..Hepatic artery reconstruction is required to preserve liver function and blood flow to the bile duct. We applied the gonadal vein to hepatic artery reconstruction...
  33. ncbi Interferon potentiates antiproliferative activity of CPT-11 against human colon cancer xenografts
    S Ohwada
    Second Department of Surgery, Gunma University School of Medicine, Maebashi, Japan
    Cancer Lett 110:149-54. 1996
    ..Because CPT-11 is known to exhibit antiproliferative effect on S-phase cells, IFNs, especially rHuIFN-alpha and beta, can enhance the antiproliferative effect of CPT-11 mediated by cell accumulation in the S-phase...
  34. ncbi Mutations in the ST7/RAY1/HELG locus rarely occur in primary colorectal, gastric, and hepatocellular carcinomas
    S Yoshimura
    Second Department of Surgery, Gunma University Faculty of Medicine, 3 39 15, Showa machi, Maebashi, Gunma 371 8511, Japan
    Br J Cancer 88:1909-13. 2003
    ..We conclude that mutations in the ST7 gene are rare in primary colorectal, gastric, and hepatocellular carcinomas...
  35. ncbi Mutational analysis of the Smad6 and Smad7 genes in hepatocellular carcinoma
    S Kawate
    Second Department of Surgery, Gunma University Faculty of Medicine, Maebashi, Gunma 371-8511, Japan
    Int J Mol Med 8:49-52. 2001
    ..These results suggest that mutations of the Smad6 and Smad7 genes are not the main cause of the TGF-beta resistance in human HCC...
  36. ncbi Left trisegmentectomy for hepatocellular carcinoma with tumor thrombi extending to the third branches in the remnant liver
    S Ohwada
    Second Department of Surgery, Gunma University School of Medicine, Maebashi, Japan
    Hepatogastroenterology 44:1385-9. 1997
    ..A successful left trisegmentectomy and tumor thrombectomy for hepatocellular carcinoma (HCC) of the right third branches in the remnant liver is described...
  37. ncbi Effects of endothelin receptor antagonist TAK-044 on small bowel autograft from a controlled non-heart-beating donor model
    Y Sunose
    Second Department of Surgery, Gunma University Faculty of Medicine, Maebashi, Japan
    Surgery 130:819-25. 2001
    ..CONCLUSIONS: TAK may have clinical application in small bowel transplantation from controlled NHBD or conditions related to ischemia-reperfusion (I/R) injury...
  38. ncbi Natural history of fibroadenomas based on the correlation between size and patient age
    H Takei
    Secondary Department of Surgery, Gunma University School of Medicine, Maebashi, Japan
    Jpn J Clin Oncol 29:8-10. 1999
    ..To understand the natural history of fibroadenomas in Japanese women, we examined the correlation between the sizes of the fibroadenomas and the women's age...
  39. ncbi Blood transfusion causes deterioration in liver regeneration after partial hepatectomy in rats
    T Okano
    Second Department of Surgery, Faculty of Medicine, Gunma University, 3-39-15 Showa-machi, Maebashi 371-8511, Japan
    J Surg Res 101:157-65. 2001
    ....
  40. ncbi Living-related liver transplantation for type II citrullinemia using a graft from heterozygote donor
    M Kasahara
    Second Department of Surgery, Gunma University Hospital, Japan
    Transplantation 71:157-9. 2001
    ..Long-term observation may be necessary to make a definite conclusion possible...
  41. ncbi Effect of a cyclooxygenase-2 inhibitor, FK3311, in a canine lung transplantation model
    Y Sunose
    Second Department of Surgery, Gunma University School of Medicine, Maebashi, Japan
    Ann Thorac Surg 72:1165-71; discussion 1171-2. 2001
    ..05) lower, but 6-keto-prostaglandin F1alpha was not significantly reduced. CONCLUSIONS: FK3311 generates protective effects on lung transplantation by a marked inhibition of thromboxane A2...
  42. ncbi Serum concentration of pyridinoline cross-linked carboxyterminal telopeptide of type I collagen in patients with metastatic breast cancer
    M Maemura
    Second Department of Surgery, Gunma University School of Medicine, Maebashi, Gunma 371 8511, Japan
    Oncol Rep 7:1333-8. 2000
    ..Combined with imaging studies, monitoring of ICTP appears to offer additional information for detection of bone metastasis and evaluation of therapeutic response to bone metastasis...
  43. ncbi Blood transfusions impair anastomotic wound healing, reduce luminol-dependent chemiluminescence, and increase interleukin-8
    T Okano
    Second Department of Surgery, Gunma University Faculty of Medicine, 3-39-15 Showa-machi, Maebashi 371-8511, Japan
    Hepatogastroenterology 48:1669-74. 2001
    ..These might be related to the reduced luminol-dependent chemiluminescence and increased interleukin-8. Autologous blood, plasma, and irradiated, leukocyte-depleted packed cells can abrogate these effects...
  44. ncbi Growth dependency of a new human pancreatic cancer cell line, YAPC, on autocrine interleukin-1alpha stimulation
    T Yamada
    Second Department of Surgery, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi Gunma, Japan
    Int J Cancer 76:141-7. 1998
    ..In this pancreatic cancer cell line cell growth is dependent on IL-1alpha in an autocrine fashion. This line may be a useful model for studying growth regulation mechanisms of pancreatic cancer...
  45. ncbi Necrotizing granulomatous vasculitis of transverse colon and gallbladder
    S Ohwada
    Second Department of Surgery, Gunma University School of Medicine, Maebashi, Japan
    Hepatogastroenterology 44:1090-4. 1997
    ..Localised PAN with allergic granulomatosis or an isolated or limited form of CSS based on these clinical features may be an alternative entity...
  46. ncbi Possible clinical and histologic manifestations of adult-onset type II citrullinemia in early infancy
    T Tomomasa
    Department of Pediatrics, Second Department of Surgery, and Division of Diagnostic Pathology, Gunma University School of Medicine, Maebashi, Japan
    J Pediatr 138:741-3. 2001
    ..Liver histology showed a marked fatty change and fibrosis. After the patients had lived without symptoms to the ages of 5 and 16 years, respectively, the diagnosis was made by genetic analysis...
  47. ncbi Increased choline kinase activity and elevated phosphocholine levels in human colon cancer
    K Nakagami
    Second Department of Surgery, Gunma University School of Medicine, Maebashi
    Jpn J Cancer Res 90:419-24. 1999
    ..This study suggests that choline kinase might play a role in growth promotion or signal transduction in carcinogenesis...
  48. ncbi A case of metachronous cholangiocellular and hepatocellular carcinoma with good prognosis
    Takashi Kosone
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi Gunma, 371-8511, Japan
    Hepatogastroenterology 52:1228-32. 2005
    ..Thus, even though the patient was treated with IFN, hepatitis C could progress to not only HCC but also CCC in the same patient. Our patient is still alive, 9.5 years after detection of the first tumor...
  49. ncbi Advanced gastric cancer with peritoneal dissemination successfully treated with paclitaxel and doxifluridine: a case report
    Izumi Takeyoshi
    Second Department of Surgery, Gunma University, Faculty of Medicine Maebashi, Gunma, Japan
    Hepatogastroenterology 52:322-5. 2005
    ..This case study suggests that paclitaxel plus doxifluridine therapy is effective and well-tolerated in non-resectable gastric cancer patients...
  50. ncbi The effects of a bradykinin B2 receptor antagonist in extended liver resection with ischemia in dogs
    Osamu Totsuka
    Second Department of Surgery, Gunma University School of Medicine, Maebashi, Gunma, Japan
    Hepatogastroenterology 51:1771-5. 2004
    ..05) reduced in the FR group compared with the control group. CONCLUSIONS: A bradykinin B2 receptor antagonist ameliorated the ischemia-reperfusion injury caused by Pringle's procedure during extended liver resection...
  51. ncbi [Four cases of advanced colorectal cancer successfully treated with irinotecan plus 5-fluorouracil and l-leucovorin combination chemotherapy]
    Norikazu Kamoshita
    Dept of Surgery, National Hospital Organization Nishigunma National Hospital
    Gan To Kagaku Ryoho 32:1187-90. 2005
    ..Grade 3 diarrhea and leukopenia were seen in one patient. All other adverse reactions were mild (grade 1 or 2). CPT-11/5-FU/l-LV combination chemotherapy appears to be effective for advanced and metastatic colorectal cancer...
  52. ncbi Effects of a free radical scavenger, MCI-186, on ischemia-reperfusion injury during extended liver resection in dogs
    Osamu Totsuka
    Second Department of Surgery, Gunma University School of Medicine, Gunma, Japan
    Hepatogastroenterology 52:1545-8. 2005
    ..05) lower in the MCI group than in the control group. CONCLUSIONS: MCI-186 ameliorates the ischemia-reperfusion injury caused by Pringle's procedure during extended liver resection...
  53. ncbi Adult onset type II citrullinemia as a cause of non-alcoholic steatohepatitis
    Hitoshi Takagi
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, Showa machi 3 39, Maebashi, Gunma 371 8511, Japan
    J Hepatol 44:236-9. 2006
    ..We demonstrated three male patients with CTLN2 having a liver histology of non-alcoholic steatohepatitis (NASH). Patients with NASH were analyzed for the causative gene of CTLN2, SLC25A13 and discussed...
  54. ncbi Factors affecting the prognosis of anatomical liver resection for liver metastases from colorectal cancer
    Naoki Tomizawa
    Department of Surgery, Gunma University Graduate School of Medicine, Maebashi Red Cross Hospital, Japan
    Hepatogastroenterology 53:89-93. 2006
    ..Liver metastases that occur within 1 year of colorectal resection may need an interval of observation before liver resection...
  55. ncbi [A recurrent endocrine cell cancer of the stomach showing almost complete remission after chemotherapy for 1 year]
    Yutaka Sunose
    Dept. of Thoracic and Visceral Organ Surgery, Gunma University School of Medicine
    Gan To Kagaku Ryoho 33:2073-6. 2006
    ..Systemic chemotherapy with TS-1 and CDDP was started, and the lesions progressed. Then, by approximately 1 year after CDDP and CPT-11 treatments, the recurrent lesions had diminished remarkably and were no longer seen on CT or FDG-PET...
  56. ncbi Combined liver and inferior vena cava resection for adrenocortical carcinoma
    Susumu Ohwada
    Department of Surgery, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma, 371 8511, Japan
    Surg Today 37:291-7. 2007
    ..We report our experience of performing combined liver and inferior vena cava (IVC) resection for ACC...
  57. ncbi Left renal vein graft for vascular reconstruction in abdominal malignancy
    Susumu Ohwada
    Department of Surgery, Gunma University, Graduate School of Medicine, Maebashi, Japan
    World J Surg 31:1215-20. 2007
    ..We used left renal vein (LRV) grafts for vascular reconstruction in patients with these malignancies and evaluated their clinical relevance...
  58. ncbi Primary liver cancers with nonalcoholic steatohepatitis
    Hiroaki Hashizume
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Eur J Gastroenterol Hepatol 19:827-34. 2007
    ..Curative therapy (surgery or RFA) and weight loss by the active therapeutic intervention (nutritional care and exercise therapy) after curative therapy may help us improve the prognosis of HCC in NASH...
  59. ncbi Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer
    Nozomi Togo
    Department of Surgery, Graduate School of Medicine, Gunma University, 3 39 22 Showa machi, Maebashi, Gunma, Japan
    World J Gastroenterol 14:4880-8. 2008
    ..We studied BAMBI expression in CRCs...
  60. ncbi Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1
    Takayuki Yamada
    Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi 371-8512, Japan
    J Biol Chem 279:6595-605. 2004
    ..LPA receptor antagonists including Ki16425 are potential therapeutic drugs against the migration and invasion of cancer cells...
  61. ncbi Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells
    Takashi Sekiya
    Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    J Biol Chem 279:6840-6. 2004
    ..These results suggest that beta-catenin interferes with transforming growth factor-beta-mediated growth arrest by inducing the expression of BAMBI, and this may contribute to colorectal and hepatocellular tumorigenesis...
  62. ncbi Cell cycle arrest and the induction of apoptosis in pancreatic cancer cells exposed to adenosine triphosphate in vitro
    Takayuki Yamada
    Second Department of Surgery, Gunma University, Showamachi, Gunma 371 8511, Japan
    Oncol Rep 9:113-7. 2002
    ..We suggest that extracellular ATP is cytotoxic for pancreatic cancer cells because of its induction of cell cycle arrest at S-phase and cell death, possibly apoptosis, overcoming the promotion of the entry into S-phase...
  63. ncbi Overexpression of Icat induces G(2) arrest and cell death in tumor cell mutants for adenomatous polyposis coli, beta-catenin, or Axin
    Takashi Sekiya
    Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113, Japan
    Cancer Res 62:3322-6. 2002
    ..These results suggest that Wnt signaling is critical for the growth of colorectal tumors and some hepatocellular carcinomas and that expression of ICAT or drugs which mimic its effects may be useful in the treatment of these tumors...
  64. ncbi Prognostic significance of DNA topoisomerase IIalpha expression in human hepatocellular carcinoma.
    Akira Watanuki
    The Second Department of Surgery, Gunma University Faculty of Medicine, Maebashi, Japan
    Anticancer Res 22:1113-9. 2002
    ..CONCLUSION: Topo IIalpha over-expression appears to be linked with a potentially aggressive tumor phenotype and may indicate tumor recurrence and cancer-related death in HCC...
  65. ncbi Effects of a p38 mitogen-activated protein kinase inhibitor as an additive to Euro-Collins solution on reperfusion injury in canine lung transplantation1
    Naoki Hashimoto
    2Second Department of Surgery, Gunma University School of Medicine, Maebashi, Japan
    Transplantation 74:320-6. 2002
    ..These results suggest that inhibiting p38 MAPK activation may attenuate ischemia/reperfusion injury in lung transplantation...
  66. ncbi Liver metastasis of rectal cancer with intraluminal growth in the extrahepatic bile duct
    Naoki Tomizawa
    Department of Surgery, Maebashi Red Cross Hospital, Maebashi, Japan
    Hepatogastroenterology 50:1625-7. 2003
    ..Liver metastasis arising from colorectal cancer with intraluminal growth in the bile duct is rare, however we encountered such a case with a successful resection involving a left trisegmentectomy of the liver...
  67. ncbi The effect of FR167653 in a canine total hepatic vascular exclusion model
    Yutaka Sunose
    Second Department of Surgery, Gunma University School of Medicine, Maebashi, Japan
    Hepatogastroenterology 50:161-4. 2003
    ..05) lower in the FR group than in the control group. CONCLUSIONS: FR167653 provides protective effects on hepatic warm ischemic injury in a canine total hepatic vascular exclusion model...
  68. ncbi Adjuvant therapy with protein-bound polysaccharide K and tegafur uracil in patients with stage II or III colorectal cancer: randomized, controlled trial
    Susumu Ohwada
    Gunma Oncology Study Group (GOSG, Maebashi, Gunma, Japan
    Dis Colon Rectum 46:1060-8. 2003
    ..These results will be a sufficient proof to conduct a larger study to compare tegafur/uracil/protein-bound polysaccharide K with 5-fluorouracil/leucovorin...
  69. ncbi [Tegafur--preoperative treatment with tegafur suppositories for rectal cancer]
    Susumu Ohwada
    Second Department of Surgery, Gunma University Faculty of Medicine
    Nippon Rinsho 61:341-4. 2003
  70. ncbi Candidate regions of tumor suppressor gene by loss of heterozygosity analysis on chromosome 8p11.1-q13.3 in gastric cancer
    Naoto Kakinuma
    Novartis Pharma Tsukuba Research Institute, Ohkubo 8, Tsukuba-shi, Ibaraki 300-2611, Japan
    Cancer Lett 213:111-6. 2004
    ..Finally, we settled six candidate regions on 8q in gastric cancer where there was a high possibility of being the tumor suppressor gene(s), and concluded that the LOH of 8q occurred in the primary tumorigenesis of gastric cancer...
  71. ncbi Effects of a bradykinin B(2) receptor antagonist, FR173657, on pulmonary ischemia-reperfusion injury in dogs
    Naoki Hashimoto
    Second Department of Surgery, Gunma University School of Medicine, Japan
    J Heart Lung Transplant 21:1022-9. 2002
    ..LTB(4) levels were significantly (p < 0.05) lower in Groups II and III than in Group IV. CONCLUSIONS: FR appears to have a protective effect on pulmonary I/R injury stemming from the inhibition of eicosanoid release...
  72. ncbi Up-regulation of a BCL9-related beta-catenin-binding protein, B9L, in different stages of sporadic colorectal adenoma
    Ichiro Sakamoto
    Department of Surgery, Gunma University, Graduate School of Medicine, Gunma University Hospital 3 39 22 Showa Machi, Maebashi, Japan
    Cancer Sci 98:83-7. 2007
    ..B9L may play an important role in tumorigenesis induced by aberrant activation of Wnt signaling and may act as a key protein in the progressive dysplasia of adenoma...
  73. ncbi Candidate regions of tumor suppressor locus on chromosome 9q31.1 in gastric cancer
    Naoto Kakinuma
    Novartis Pharma Tsukuba Research Institute, Ibaraki, Japan
    Int J Cancer 109:71-5. 2004
    ..Furthermore, this deletion was found in the primary tumors of early-stage gastric cancer, indicating that loss of function of predicted genes appears to be associated with the tumorigenesis of gastric cancer...
  74. ncbi The effects of a selective cyclooxygenase-2 inhibitor on small bowel ischemia-reperfusion injury
    Kiyoshi Kawata
    Second Department of Surgery, Gunma University School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan
    Hepatogastroenterology 50:1970-4. 2003
    ..05) lower in the FK group compared to the control group. CONCLUSIONS: FK protects the small bowel from ischemia-reperfusion injury by suppression of prostanoid production...
  75. ncbi PH domain-mediated membrane targeting of Asef
    Ken Muroya
    Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Biochem Biophys Res Commun 355:85-8. 2007
    ..These results suggest that Asef is targeted via its PH domain to the cell-cell adhesion sites and is involved in the regulation of cell adhesion...
  76. ncbi Compressed spectral arrays of patients with fulminant hepatic failure in hepatic coma undergoing liver transplantation
    Takayuki Takeichi
    Department of Transplantation and Immunology, Kyoto University School of Medicine, Kyoto, Japan
    Clin Transplant 16:273-9. 2002
    ..One patient died without regaining consciousness. These results suggest that CSA is useful in assessing the coma status of FHF patients and in evaluating electrophysiological recovery from hepatic coma after liver transplantation...
  77. ncbi Biological properties and gene expression associated with metastatic potential of human osteosarcoma
    Tetsuhiro Nakano
    Division of Biology, National Cancer Center Research Institute, Tokyo, Japan
    Clin Exp Metastasis 20:665-74. 2003
    ..These results suggest that the differences in motility/invasiveness and adhesive abilities are key determinants of lung metastasis in osteosarcoma...
  78. ncbi Novel clusters of highly expressed genes accompany genomic amplification in breast cancers
    Emi Ito
    Department of Clinical Informatics, Tokyo Medical and Dental University School of Medicine, Tokyo, Japan
    FEBS Lett 581:3909-14. 2007
    ..Highly expressed genes identified in the amplicons will contribute to the characterization of breast cancer phenotypes, thereby providing novel targets for anticancer therapies...
  79. ncbi A hemophagocytic syndrome-like condition after emergency colectomy for perforated colon cancer: report of a case
    Takayuki Yamada
    Department of Surgery, Maebashi Red Cross Hospital, Gunma, Japan
    Surg Today 32:278-81. 2002
    ..Hemophagocytic syndrome was suspected, and predonine was administered. The patient's condition improved remarkably and he was discharged on POD 51...
  80. ncbi Mutation and expression of the beta-catenin-interacting protein ICAT in human colorectal tumors
    Toru Koyama
    Second Department of Surgery, Gunma University School of Medicine, Maebashi, Laboratory of Molecular and Genetic Information, Institution of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan
    Jpn J Clin Oncol 32:358-62. 2002
    ..We have recently identified the ICAT gene, which encodes a small protein that interacts with beta-catenin and represses Wnt signaling...
  81. ncbi Frameshift mutations in the MBD4/MED1 gene in primary gastric cancer with high-frequency microsatellite instability
    Tatsuya Yamada
    Second Department of Surgery, Gunma University Faculty of Medicine, 39 15, Showa machi 3 chome, Maebashi, Gunma 371 8511, Japan
    Cancer Lett 181:115-20. 2002
    ..MBD4/MED1 is mutated in gastric cancers as frequently as in colon cancers; these mutations reduce the accuracy of DNA repair, and may lead to cancer progression...
  82. ncbi Primary liver somatostatinoma
    Susumu Ohwada
    J Gastroenterol Hepatol 18:1218-9. 2003
  83. ncbi Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling
    Shungo Adachi
    Institute for Molecular and Cellular Biosciences and Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Cancer Res 64:8496-501. 2004
    ..These results suggest that B9L plays an important role in tumorigenesis induced by aberrant activation of Wnt signaling...
  84. ncbi Genetic and epigenetic alterations of the candidate tumor-suppressor gene MYO18B, on chromosome arm 22q, in colorectal cancer
    Tetsuhiro Nakano
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Genes Chromosomes Cancer 43:162-71. 2005
    ..These results suggest that genetic and epigenetic inactivation of the MYO18B gene play an important role in colorectal carcinogenesis...
  85. ncbi Cloning of novel LERGU mRNAs in GPR30 3' untranslated region and detection of 2 bp-deletion polymorphism in gastric cancer
    Naoto Kakinuma
    Tsukuba Research Institute, Novartis Pharma K K, Ohkubo 8, Tsukuba shi Ibaraki 300 2611, Japan
    Cancer Sci 96:191-6. 2005
    ..Overall, our findings suggest that a mutation or disappearance of the normal LERGU protein may have a function in the development of gastric cancer...
  86. ncbi Malignant gastrointestinal stromal tumor of the jejunum with liver metastasis
    Norikazu Kamoshita
    Department of Surgery, Ojiya General Hospital, Japan
    Hepatogastroenterology 49:1311-4. 2002
    ..This case was a malignant gastrointestinal stromal tumor originating in the jejunum with liver metastases. The primary tumor and liver metastases were successfully resected simultaneously...
  87. ncbi Ampullary carcinoma associated with protein-losing gastropathy due to diffuse varioliform gastritis
    Yoshihiro Sato
    Ohta Fukushima General Hospital, Ohta, Japan
    Hepatogastroenterology 52:1143-6. 2005
    ..Anemia, hypoalbuminemia and diffuse varioliform gastritis are improved 6 months after surgery and H. pylori eradication, and the patient is currently free from disease...
  88. ncbi Exfoliative rejection after intestinal transplantation in children
    Tomohiro Ishii
    Department of Transplant Surgery, Division of Pediatric Gastroenterology, Children's Hospital Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Pediatr Transplant 7:185-91. 2003
    ..Strategies to improve survival may include up front anti-lymphocyte antibody therapy and, when fail to respond promptly and satisfactorily, early intestinal allograft removal...
  89. ncbi Effects of a bradykinin B(2) receptor antagonist on ischemia-reperfusion injury in a canine lung transplantation model
    Naoki Hashimoto
    Second Department of Surgery, Gunma University School of Medicine, Maebashi, Gunma, Japan
    J Heart Lung Transplant 23:606-13. 2004
    ..05) reduced. CONCLUSIONS: The bradykinin B(2) receptor antagonist, FR173657, ameliorates I/R injury in lung grafts, indicating that protection of lung grafts can be achieved by the administration of FR solely to the transplant recipient...
  90. ncbi Ileal perforation caused by cytomegalovirus infection in a patient with recurrent gastric cancer: report of a case
    Susumu Kawate
    Second Department of Surgery, Gunma University School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan
    Surg Today 32:1088-90. 2002
    ..There was no evidence of cancer cell invasion or any other pathogens. Although the prognosis associated with bowel perforation due to CMV infection is poor, emergency surgery saved our patient's life...
  91. ncbi [A case of pancreatic tail cancer with peritoneal carcinosis treated with gemcitabine hydrochloride]
    Takayuki Yamada
    Dept. of Surgery, National Numata Hospital
    Gan To Kagaku Ryoho 29:1977-80. 2002
    ..Gemcitabine hydrochloride may have not only reduced the tumor volume and improved cancer cachexic condition, but also prolonged the survival time in this case...
  92. ncbi Mutational analysis of the BAK gene in 192 advanced gastric and colorectal cancers
    Ichiro Sakamoto
    Second Department of Surgery, Gunma University Faculty of Medicine, 3-39-35 Showa-machi, Maebashi, Gunma 371-8511, Japan
    Int J Mol Med 13:53-5. 2004
    ..We found only four single-nucleotide substitutions in the coding sequences, which were also found in corresponding normal samples. We conclude that somatic alterations of the BAK gene are rare in colorectal and gastric cancers...