H Obata

Summary

Affiliation: Gunma University
Country: Japan

Publications

  1. pmc Milnacipran inhibits glutamatergic N-methyl-D-aspartate receptor activity in spinal dorsal horn neurons
    Tatsuro Kohno
    Department of Anesthesiology, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachi, Japan
    Mol Pain 8:45. 2012
  2. ncbi Antiallodynic effects of intrathecally administered 5-HT(2C) receptor agonists in rats with nerve injury
    Hideaki Obata
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3 39 22, Maebashi, Gunma 371 5811, Japan
    Pain 108:163-9. 2004
  3. ncbi Possible involvement of a muscarinic receptor in the anti-allodynic action of a 5-HT2 receptor agonist in rats with nerve ligation injury
    Hideaki Obata
    Department of Anesthesiology and Reanimatology, Gunma University, School of Medicine, 3 39 22, Showa machi, Maebashi, Gunma 371 8511, Japan
    Brain Res 932:124-8. 2002
  4. ncbi The monoamine-mediated antiallodynic effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a rat model of neuropathic pain
    Hideaki Obata
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3 39 22 Showa, Maebashi, Gunma 371 8511, Japan
    Anesth Analg 100:1406-10, table of contents. 2005
  5. ncbi Possible involvement of spinal noradrenergic mechanisms in the antiallodynic effect of intrathecally administered 5-HT2C receptor agonists in the rats with peripheral nerve injury
    Hideaki Obata
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3 39 22, Showa, Maebashi, Gunma, 371 0801 Japan
    Eur J Pharmacol 567:89-94. 2007
  6. ncbi Antiallodynic effect of intrathecally administered 5-HT(2) agonists in rats with nerve ligation
    H Obata
    Department of Anesthesiology and Reanimatology, Gunma University, School of Medicine, 3 39 22 Showa machi, Maebashi, 371 8511, Gunma, Japan
    Pain 90:173-9. 2001
  7. doi Monoamine-dependent, opioid-independent antihypersensitivity effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a postoperative pain model in rats
    Hideaki Obata
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3 39 22 Showa, Maebashi, Gunma 371 8511, Japan
    J Pharmacol Exp Ther 334:1059-65. 2010
  8. ncbi Antinociception in rat by sarpogrelate, a selective 5-HT(2A) receptor antagonist, is peripheral
    H Obata
    Department of Anesthesiology and Reanimatology, Gunma University, School of Medicine, 3 39 22, Showa machi, Gunma, 371 8511, Maebashi, Japan
    Eur J Pharmacol 404:95-102. 2000
  9. doi Activation of astrocytes in the spinal cord contributes to the development of bilateral allodynia after peripheral nerve injury in rats
    Hideaki Obata
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3 39 22, Showa machi, Maebashi, Gunma 371 8511, Japan
    Brain Res 1363:72-80. 2010
  10. ncbi Effects of 5-HT2 and 5-HT3 receptors on the modulation of nociceptive transmission in rat spinal cord according to the formalin test
    M Sasaki
    Department of Anesthesiology and Reanimatology, Gunma University School of Medicine, 3 39 22 Shouwa machi, Gunma, 371 8511, Maebashi, Japan
    Eur J Pharmacol 424:45-52. 2001

Collaborators

Detail Information

Publications35

  1. pmc Milnacipran inhibits glutamatergic N-methyl-D-aspartate receptor activity in spinal dorsal horn neurons
    Tatsuro Kohno
    Department of Anesthesiology, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachi, Japan
    Mol Pain 8:45. 2012
    ..The effects of milnacipran followed by application of NMDA on pERK activation were also investigated in the spinal cord...
  2. ncbi Antiallodynic effects of intrathecally administered 5-HT(2C) receptor agonists in rats with nerve injury
    Hideaki Obata
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3 39 22, Maebashi, Gunma 371 5811, Japan
    Pain 108:163-9. 2004
    ....
  3. ncbi Possible involvement of a muscarinic receptor in the anti-allodynic action of a 5-HT2 receptor agonist in rats with nerve ligation injury
    Hideaki Obata
    Department of Anesthesiology and Reanimatology, Gunma University, School of Medicine, 3 39 22, Showa machi, Maebashi, Gunma 371 8511, Japan
    Brain Res 932:124-8. 2002
    ..Thus, muscarinic receptors may be involved in the anti-allodynic action of intrathecally injected 5-HT(2) receptor agonist...
  4. ncbi The monoamine-mediated antiallodynic effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a rat model of neuropathic pain
    Hideaki Obata
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3 39 22 Showa, Maebashi, Gunma 371 8511, Japan
    Anesth Analg 100:1406-10, table of contents. 2005
    ..These findings suggest that simultaneous inhibition of serotonin and noradrenaline reuptake in the spinal cord is essential to mediate antiallodynic effects. Milnacipran might be effective for suppression of neuropathic pain...
  5. ncbi Possible involvement of spinal noradrenergic mechanisms in the antiallodynic effect of intrathecally administered 5-HT2C receptor agonists in the rats with peripheral nerve injury
    Hideaki Obata
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3 39 22, Showa, Maebashi, Gunma, 371 0801 Japan
    Eur J Pharmacol 567:89-94. 2007
    ..Taken together, these findings suggest that 5-HT(2A) and 5-HT(2C) receptors in the dorsal horn of the spinal cord might be involved in alleviating neuropathic pain by different mechanisms...
  6. ncbi Antiallodynic effect of intrathecally administered 5-HT(2) agonists in rats with nerve ligation
    H Obata
    Department of Anesthesiology and Reanimatology, Gunma University, School of Medicine, 3 39 22 Showa machi, Maebashi, 371 8511, Gunma, Japan
    Pain 90:173-9. 2001
    ..These results indicate that the 5-HT(2) receptor plays an essential role in spinal suppression of neuropathic pain by 5-HT...
  7. doi Monoamine-dependent, opioid-independent antihypersensitivity effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a postoperative pain model in rats
    Hideaki Obata
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3 39 22 Showa, Maebashi, Gunma 371 8511, Japan
    J Pharmacol Exp Ther 334:1059-65. 2010
    ..Combined administration of an SNRI with morphine might be a promising treatment to suppress postoperative hypersensitivity...
  8. ncbi Antinociception in rat by sarpogrelate, a selective 5-HT(2A) receptor antagonist, is peripheral
    H Obata
    Department of Anesthesiology and Reanimatology, Gunma University, School of Medicine, 3 39 22, Showa machi, Gunma, 371 8511, Maebashi, Japan
    Eur J Pharmacol 404:95-102. 2000
    ..The data imply that the antinociceptive effect of sarpogrelate results mainly from an action at peripheral sites...
  9. doi Activation of astrocytes in the spinal cord contributes to the development of bilateral allodynia after peripheral nerve injury in rats
    Hideaki Obata
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3 39 22, Showa machi, Maebashi, Gunma 371 8511, Japan
    Brain Res 1363:72-80. 2010
    ..These results suggest that activation of spinal glia, especially astrocytes, dominantly contributes to the development of neuropathic pain and also to mirror-image pain...
  10. ncbi Effects of 5-HT2 and 5-HT3 receptors on the modulation of nociceptive transmission in rat spinal cord according to the formalin test
    M Sasaki
    Department of Anesthesiology and Reanimatology, Gunma University School of Medicine, 3 39 22 Shouwa machi, Gunma, 371 8511, Maebashi, Japan
    Eur J Pharmacol 424:45-52. 2001
    ..These results suggest that 5-HT2 and 5-HT3 receptors in the spinal cord mediate antinociception to chemical stimuli...
  11. ncbi Antinociception with intrathecal alpha-methyl-5-hydroxytryptamine, a 5-hydroxytryptamine 2A/2C receptor agonist, in two rat models of sustained pain
    Masayuki Sasaki
    Department of Anesthesiology and Reanimatology, Gunma University School of Medicine, 3 39 22 Showa machi, Maebashi 371 8511, Japan
    Anesth Analg 96:1072-8, table of contents. 2003
    ..These findings suggest that spinal 5-HT(2A/2C) receptors mediate antinociception in inflammatory pain and neuropathic pain, and the muscarinic receptors contribute to this action...
  12. ncbi A rat model of postthoracotomy pain: behavioural and spinal cord NK-1 receptor assessment
    T Nara
    Department of Anesthesiology, Gunma University School of Medicine, Gunma, Japan
    Can J Anaesth 48:665-76. 2001
    ..CONCLUSION: Intercostal nerve damage induces long-term postthoracotomy pain and an increase of spinal NK-1 receptors in rats. This model may be useful for investigation of postthoracotomy pain...
  13. ncbi Reduction of cerebral hyperemia with anti-hypertensive medication after electroconvulsive therapy
    S Saito
    Department of Anesthesiology and Reanimatology, Gunma University School of Medicine, Showamachi, Maebashi, Japan
    Can J Anaesth 47:767-74. 2000
    ..In the present study, the effects of anti-hypertensive medications on cerebral circulation were studied...
  14. ncbi Interactions of 5-HT2 receptor agonists with acetylcholine in spinal analgesic mechanisms in rats with neuropathic pain
    Hideaki Obata
    Department of Anesthesiology and Reanimatology, Gunma University School of Medicine, 3 39 22, Showa machi, Maebashi 371 8511, Japan
    Brain Res 965:114-20. 2003
    ..Antiallodynic effects of intrathecally administered 5-HT(2) receptor agonists may be mediated by spinal release of acetylcholine induced via 5-HT(2A) and NK(1) receptors...
  15. doi Spinal microglial expression and mechanical hypersensitivity in a postoperative pain model: comparison with a neuropathic pain model
    Naomi Ito
    Department of Anesthesiology, Gunma University Graduate School of Medicine, Showa, Maebashi, Gunma, Japan
    Anesthesiology 111:640-8. 2009
    ..Here, the authors evaluated whether inhibition of spinal microglia reduced postoperative mechanical hypersensitivity, and if so, whether the effect differed from that in a rat neuropathic pain model...
  16. ncbi Spinal glial activation contributes to postoperative mechanical hypersensitivity in the rat
    Hideaki Obata
    Department of Anesthesiology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    J Pain 7:816-22. 2006
    ..Spinal cord glial activation contributes to the mechanical hypersensitivity that develops after hind paw incision...
  17. ncbi The long lasting effects of peripheral nerve blocks for trigeminal neuralgia using high concentration of tetracaine dissolved in bupivacaine
    F Goto
    Department of Anesthesiology and Reanimatology, Gunma University School of Medicine, Maebashi shi, Japan
    Pain 79:101-3. 1999
    ..5% bupivacaine continued for more than 3 months. Hypesthesia was observed in two patients within a week following the block, but sensory level returned to normal within 2 weeks and there were no further complications in any patient...
  18. doi Percutaneous radio-frequency thermocoagulation of the Gasserian ganglion guided by high-speed real-time CT fluoroscopy
    Shiro Koizuka
    Department of Anesthesiology, Gunma University Graduate School of Medicine, Maebashi, Japan
    Neuroradiology 51:563-6. 2009
    ..We present a new method for percutaneous radio-frequency thermocoagulation of the Gasserian ganglion, in which computed tomography (CT) fluoroscopy is used to guide needle placement...
  19. doi The nociceptive mechanism of 5-hydroxytryptamine released into the peripheral tissue in acute inflammatory pain in rats
    Kunie Nakajima
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Eur J Pain 13:441-7. 2009
    ..These results indicate that 5-HT released into peripheral tissue and its receptors, 5-HT2A as well as 5-HT2C, at the periphery have an important role in pain-related behaviors during acute peripheral inflammation...
  20. doi Technical communication: percutaneous radiofrequency mandibular nerve rhizotomy guided by high-speed real-time computed tomography fluoroscopy
    Shiro Koizuka
    Department of Anesthesiology, Gunma University Hospital, 3 39 15 Showa Machi, Maebashi 371 8511, Japan
    Anesth Analg 111:763-7. 2010
    ..9 (+ or - 1.0, 3 months after treatment). Our limited-case series suggests potential advantages for the new CT fluoroscopy guidance, but these findings await confirmation from randomized controlled trials and large-case series...
  21. ncbi Intracellular calcium increases in growth cones exposed to tetracaine
    Shigeru Saito
    Department of Anesthesiology, Gunma University Graduate School of Medicine, Maebashi, Japan
    Anesth Analg 98:841-5, table of contents. 2004
    ..Tetracaine (>1 mM) induces collapse and Ca(2+) increase at growth cones simultaneously; however, these two phenomena might be provoked independently...
  22. ncbi Peripheral 5-HT2A receptor antagonism attenuates primary thermal hyperalgesia and secondary mechanical allodynia after thermal injury in rats
    Masayuki Sasaki
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3 39 22, Showa, Maebashi, Gunma 371 8511, Japan
    Pain 122:130-6. 2006
    ..p.). These data suggest that 5-HT released in peripheral tissues after thermal injury sensitizes primary afferent neurons and produces mechanical allodynia and thermal hyperalgesia via peripheral 5-HT2A receptors...
  23. ncbi Landiolol and esmolol prevent tachycardia without altering cerebral blood flow
    Shigeru Saito
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3 39 22, Showamachi, Maebashi 371 8511, Japan
    Can J Anaesth 52:1027-34. 2005
    ..The effects of two ultra-short acting ss-adrenergic-blocking drugs, esmolol and landiolol, on systemic and cerebral circulation were studied during ECT...
  24. ncbi The comparative effects of propofol versus thiopental on middle cerebral artery blood flow velocity during electroconvulsive therapy
    S Saito
    Department of Anesthesiology and Reanimatology, Gunma University School of Medicine, Maebashi, Japan
    Anesth Analg 91:1531-6. 2000
    ..Propofol anesthesia may be suitable for patients who cannot tolerate abrupt cerebral hemodynamic change...
  25. ncbi Oral etodolac, a COX-2 inhibitor, reduces postoperative pain immediately after fast-track cardiac surgery
    Shiro Koizuka
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, 371 8511, Maebashi, Japan
    J Anesth 18:9-13. 2004
    ....
  26. ncbi Systemic ketamine inhibits hypersensitivity after surgery via descending inhibitory pathways in rats
    Shiro Koizuka
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3 39 22, Showa machi, Maebashi, Gunma, 371 8511, Japan
    Can J Anaesth 52:498-505. 2005
    ..We investigated the efficacy and mechanism of systemic ketamine in a rat model of postoperative pain...
  27. ncbi Direct neurotoxicity of tetracaine on growth cones and neurites of growing neurons in vitro
    S Saito
    Department of Anesthesiology and Reanimatology, Gunma University School of Medicine, Maebashi, Japan
    Anesthesiology 95:726-33. 2001
    ..Also, despite the fact that local anesthetics are sometimes applied to the sites where peripheral nerves may be regenerating after injury, the effects of local anesthetics on growing or regenerating neurons have never been studied...
  28. ncbi alpha2-Adrenoceptor activation by clonidine enhances stimulation-evoked acetylcholine release from spinal cord tissue after nerve ligation in rats
    Hideaki Obata
    Department of Anesthesiology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Anesthesiology 102:657-62. 2005
    ..The authors hypothesized that these changes reflect greater acetylcholine release from the spinal cord by clonidine, either through direct or indirect effects...
  29. ncbi Accuracy of carboxyhemoglobin dilution method for the measurement of circulating blood volume
    S Ohki
    Second Department of Surgery, Gunma University School of Medicine, Maebashi, Japan
    Can J Anaesth 47:150-4. 2000
    ....
  30. doi A novel bFGF-GH injection therapy for two patients with severe ischemic limb pain
    Naomi Ito
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, 371 8511, Japan
    J Anesth 22:449-52. 2008
    ..A multimodal approach is necessary to treat severe ischemic pain. Novel angiogenic therapy combined with nerve blocks seems to be a promising option in patients with severe pain...
  31. doi Anatomic analysis of computed tomography images obtained during fluoroscopic computed tomography-guided percutaneous lumbar sympathectomy
    Shiro Koizuka
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, 371 8511, Japan
    J Anesth 22:373-7. 2008
    ..The aim of the present study was to provide anatomic data from CT images and to discuss the safest route for needle insertion...
  32. doi Long-term effect of sciatic nerve block with slow-release lidocaine in a rat model of postoperative pain
    Masaru Tobe
    Department of Anesthesiology, Gunma University Graduate School of Medicine, Maebashi, Japan
    Anesthesiology 112:1473-81. 2010
    ..Postoperative pain management is important for preventing perioperative complications. The authors examined the effectiveness of controlled-release lidocaine for sciatic nerve block in a rat model of postoperative pain...
  33. ncbi [Alpha2-adrenergic receptors in the dorsal horn of the spinal cord--their function and the descending inhibitory systems]
    Hideaki Obata
    Department of Anesthesiology, Wake Forest University School of Medicine, USA
    Masui 56:S161-71. 2007
  34. ncbi Spinal noradrenaline transporter inhibition by reboxetine and Xen2174 reduces tactile hypersensitivity after surgery in rats
    Hideaki Obata
    Department of Anesthesiology and Center for the Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Pain 113:271-6. 2005
    ..Finally, these data suggest that intrathecal administration of Xen2174 at the time of spinal anesthesia might produce postoperative analgesia in humans...
  35. ncbi Spinal adenosine receptor activation reduces hypersensitivity after surgery by a different mechanism than after nerve injury
    Hideaki Obata
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Anesthesiology 100:1258-62. 2004
    ..Here, the authors tested whether this same dependence was present in the acute setting of hypersensitivity after surgery...