Sumiyo Morita

Summary

Affiliation: Gunma University
Country: Japan

Publications

  1. pmc miR-29 represses the activities of DNA methyltransferases and DNA demethylases
    Sumiyo Morita
    Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371 8512, Japan
    Int J Mol Sci 14:14647-58. 2013
  2. pmc Genome-Wide Analysis of DNA Methylation and Expression of MicroRNAs in Breast Cancer Cells
    Sumiyo Morita
    Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371 8512, Japan E Mails S M T H M K
    Int J Mol Sci 13:8259-72. 2012
  3. pmc Astrocyte-specific genes are generally demethylated in neural precursor cells prior to astrocytic differentiation
    Izuho Hatada
    Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan
    PLoS ONE 3:e3189. 2008
  4. doi request reprint Genome-wide demethylation during neural differentiation of P19 embryonal carcinoma cells
    Izuho Hatada
    Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, 3 39 15 Showa Machi, Maebashi 371 8512, Japan
    J Hum Genet 53:185-91. 2008
  5. pmc Epigenetic regulation of adipocyte differentiation by a Rho guanine nucleotide exchange factor, WGEF
    Takuro Horii
    Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan
    PLoS ONE 4:e5809. 2009
  6. ncbi request reprint The Dnmt3b splice variant is specifically expressed in in vitro-manipulated blastocysts and their derivative ES cells
    Takuro Horii
    Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371 8512, Japan
    J Reprod Dev 57:579-85. 2011
  7. ncbi request reprint Microarray analysis of promoter methylation in lung cancers
    Masayuki Fukasawa
    Laboratory of Genome Science, Biosignal Genome Resource Center, Department of Molecular and Cellular Biology, Gunma University, 3 39 15 Showa Machi, Maebashi 371 8512, Japan
    J Hum Genet 51:368-74. 2006
  8. doi request reprint Epigenetic differences between embryonic stem cells generated from blastocysts developed in vitro and in vivo
    Takuro Horii
    Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Japan
    Cell Reprogram 12:551-63. 2010
  9. ncbi request reprint One Argonaute family member, Eif2c2 (Ago2), is essential for development and appears not to be involved in DNA methylation
    Sumiyo Morita
    Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, 3 39 15 Showa Machi, Maebashi 371 8512, Japan
    Genomics 89:687-96. 2007
  10. pmc Dicer is required for maintaining adult pancreas
    Sumiyo Morita
    Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Showa Machi Maebashi, Japan
    PLoS ONE 4:e4212. 2009

Collaborators

Detail Information

Publications16

  1. pmc miR-29 represses the activities of DNA methyltransferases and DNA demethylases
    Sumiyo Morita
    Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371 8512, Japan
    Int J Mol Sci 14:14647-58. 2013
    ....
  2. pmc Genome-Wide Analysis of DNA Methylation and Expression of MicroRNAs in Breast Cancer Cells
    Sumiyo Morita
    Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371 8512, Japan E Mails S M T H M K
    Int J Mol Sci 13:8259-72. 2012
    ..This is only rarely observed in other gene categories, including miRNAs. The present study highlights the epigenetic similarities and differences between miRNA and protein-coding genes...
  3. pmc Astrocyte-specific genes are generally demethylated in neural precursor cells prior to astrocytic differentiation
    Izuho Hatada
    Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan
    PLoS ONE 3:e3189. 2008
    ..Thus, late-stage NPCs have epigenetic potential which can be realized in their expression after astrocyte differentiation...
  4. doi request reprint Genome-wide demethylation during neural differentiation of P19 embryonal carcinoma cells
    Izuho Hatada
    Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, 3 39 15 Showa Machi, Maebashi 371 8512, Japan
    J Hum Genet 53:185-91. 2008
    ..We found a genome-wide demethylation of genes. This suggests demethylation rather than methylation is important in neural differentiation...
  5. pmc Epigenetic regulation of adipocyte differentiation by a Rho guanine nucleotide exchange factor, WGEF
    Takuro Horii
    Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan
    PLoS ONE 4:e5809. 2009
    ..This study clarified that adipogenesis was regulated by WGEF expression through DNA methylation change...
  6. ncbi request reprint The Dnmt3b splice variant is specifically expressed in in vitro-manipulated blastocysts and their derivative ES cells
    Takuro Horii
    Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371 8512, Japan
    J Reprod Dev 57:579-85. 2011
    ..In vitro methylation activity assays showed that Dnmt3bΔ6 had lower activity than normal Dnmt3b. Our findings suggest that Dnmt3bΔ6 could induce a hypomethylation status especially in in vitro manipulated embryos...
  7. ncbi request reprint Microarray analysis of promoter methylation in lung cancers
    Masayuki Fukasawa
    Laboratory of Genome Science, Biosignal Genome Resource Center, Department of Molecular and Cellular Biology, Gunma University, 3 39 15 Showa Machi, Maebashi 371 8512, Japan
    J Hum Genet 51:368-74. 2006
    ..This demonstrates that our PMAD method is effective at finding epigenetic changes during cancer...
  8. doi request reprint Epigenetic differences between embryonic stem cells generated from blastocysts developed in vitro and in vivo
    Takuro Horii
    Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Japan
    Cell Reprogram 12:551-63. 2010
    ..In conclusion, it is advisable to use early passage Vivo ES cells whenever feasible, or to select ES cell lines with a normal epigenotype...
  9. ncbi request reprint One Argonaute family member, Eif2c2 (Ago2), is essential for development and appears not to be involved in DNA methylation
    Sumiyo Morita
    Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, 3 39 15 Showa Machi, Maebashi 371 8512, Japan
    Genomics 89:687-96. 2007
    ..This suggests that developmental defects in the Eif2c2-deficient mouse are caused not at the transcriptional level, but rather at the posttranscriptional level through the miRNA-protein complex...
  10. pmc Dicer is required for maintaining adult pancreas
    Sumiyo Morita
    Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Showa Machi Maebashi, Japan
    PLoS ONE 4:e4212. 2009
    ..This suggested that Dicer1 is important for maintaining the adult pancreas...
  11. ncbi request reprint Loss of genomic imprinting in mouse parthenogenetic embryonic stem cells
    Takuro Horii
    Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Gunma, Japan
    Stem Cells 26:79-88. 2008
    ..On the other hand, in germ lineages, both PGES and PG in chimeras showed normal erasure of imprints, indicating that the reprogramming in germ lineages is an inevitable event, regardless of the imprint status of primordial germ cells...
  12. doi request reprint MeCP2-dependent repression of an imprinted miR-184 released by depolarization
    Tasuku Nomura
    Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, 3 39 15 Showa Machi, Maebashi 371 8512, Japan
    Hum Mol Genet 17:1192-9. 2008
    ..The restricted release of MeCP2 from the paternal allele results in paternal allele-specific expression of miR-184. Our finding provides a clue to the link between the microRNA and DNA methylation pathways...
  13. pmc Generation of an ICF syndrome model by efficient genome editing of human induced pluripotent stem cells using the CRISPR system
    Takuro Horii
    Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371 8512, Japan
    Int J Mol Sci 14:19774-81. 2013
    ..We obtained iPS cells with mutations in both alleles of DNA methyltransferase 3B (DNMT3B) in 63% of transfected clones. Our data suggest that the CRISPR system is highly efficient and useful for genome engineering of human iPS cells. ..
  14. ncbi request reprint Validation of microinjection methods for generating knockout mice by CRISPR/Cas-mediated genome engineering
    Takuro Horii
    1 Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, 3 39 15 Showa Machi, Maebashi, Gunma 371 8512, Japan 2
    Sci Rep 4:4513. 2014
    ..We found that injection of RNA into the cytoplasm was the most efficient method in terms of the numbers of viable blastocyst stage embryos and full-term pups generated. This method also showed the best overall knockout efficiency. ..
  15. pmc Paternal allele influences high fat diet-induced obesity
    Sumiyo Morita
    Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Showa Machi Maebashi, Japan
    PLoS ONE 9:e85477. 2014
    ..Taken together, our findings suggest that the down-regulation of Igf2 and Peg3 imprinted genes in adipocytes may be involved in the paternal transmission of HFD-induced obesity. ..
  16. ncbi request reprint A microarray-based method for detecting methylated loci
    Izuho Hatada
    Gene Research Center, Gunma University, 3 39 22 Showa machi, Maebashi 371 8511, Japan
    J Hum Genet 47:448-51. 2002
    ..Choosing the methylated DNA library as the resource material of the microarray increased the percentage of DNA fragments derived from hypermethylated loci on the microarray...