Yuji Mizuno

Summary

Affiliation: Gunma University
Country: Japan

Publications

  1. ncbi request reprint Synemin expression in brain
    Yuji Mizuno
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showa, Maebashi, Gunma, Japan
    Muscle Nerve 36:497-504. 2007
  2. doi request reprint Comparison of phosphorylated TDP-43-positive inclusions in oculomotor neurons in patients with non-ALS and ALS disorders
    Yuji Mizuno
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    J Neurol Sci 315:20-5. 2012
  3. ncbi request reprint Transferrin localizes in Bunina bodies in amyotrophic lateral sclerosis
    Yuji Mizuno
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma, Japan
    Acta Neuropathol 112:597-603. 2006
  4. ncbi request reprint Immunoreactivities of p62, an ubiqutin-binding protein, in the spinal anterior horn cells of patients with amyotrophic lateral sclerosis
    Yuji Mizuno
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    J Neurol Sci 249:13-8. 2006
  5. ncbi request reprint Nestin immunoreactivity of Purkinje cells in Creutzfeldt-Jakob disease
    Yuji Mizuno
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    J Neurol Sci 246:131-7. 2006
  6. ncbi request reprint Beta-synemin localizes to regions of high stress in human skeletal myofibers
    Yuji Mizuno
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showa, Maebashi, Gunma 371 8511, Japan
    Muscle Nerve 30:337-46. 2004
  7. ncbi request reprint Expression of nestin in ballooned neurons in patients with Creutzfeldt-Jakob disease
    Yuji Mizuno
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Neurosci Lett 366:144-7. 2004
  8. ncbi request reprint Expression of nestin in Purkinje cells in patients with Creutzfeldt-Jakob disease
    Yuji Mizuno
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Neurosci Lett 352:109-12. 2003
  9. ncbi request reprint Vacuole-creating protein in neurodegenerative diseases in humans
    Yuji Mizuno
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Neurosci Lett 343:77-80. 2003
  10. pmc Beta-synemin expression in cardiotoxin-injected rat skeletal muscle
    Yuji Mizuno
    Department of Neurology, Gunma University Graduate School of Medicine, Showa, Maebashi, Gunma, Japan
    BMC Musculoskelet Disord 8:40. 2007

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Synemin expression in brain
    Yuji Mizuno
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showa, Maebashi, Gunma, Japan
    Muscle Nerve 36:497-504. 2007
    ..Our findings show where synemin is expressed in brain and allow one to speculate with regard to its function in neural tissue...
  2. doi request reprint Comparison of phosphorylated TDP-43-positive inclusions in oculomotor neurons in patients with non-ALS and ALS disorders
    Yuji Mizuno
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    J Neurol Sci 315:20-5. 2012
    ..Although the mechanisms underlying pTDP-43 in oculomotor neurons are currently unknown, its detection is of interest, and the expression may occur not only in ALS but also during the aging process...
  3. ncbi request reprint Transferrin localizes in Bunina bodies in amyotrophic lateral sclerosis
    Yuji Mizuno
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma, Japan
    Acta Neuropathol 112:597-603. 2006
    ..Furthermore, following cystatin C, transferrin is the second protein that localizes in the Bunina bodies...
  4. ncbi request reprint Immunoreactivities of p62, an ubiqutin-binding protein, in the spinal anterior horn cells of patients with amyotrophic lateral sclerosis
    Yuji Mizuno
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    J Neurol Sci 249:13-8. 2006
    ..Our results suggested that p62 plays important roles in forming the inclusions and may be associated with the protection of the neurons from degenerative processes involving ubiquitin...
  5. ncbi request reprint Nestin immunoreactivity of Purkinje cells in Creutzfeldt-Jakob disease
    Yuji Mizuno
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    J Neurol Sci 246:131-7. 2006
    ..Although the mechanism of nestin expression in Purkinje cells is not yet understood, we suggest that such nestin-positive Purkinje cells are being reactivated to survive the cell death...
  6. ncbi request reprint Beta-synemin localizes to regions of high stress in human skeletal myofibers
    Yuji Mizuno
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showa, Maebashi, Gunma 371 8511, Japan
    Muscle Nerve 30:337-46. 2004
    ....
  7. ncbi request reprint Expression of nestin in ballooned neurons in patients with Creutzfeldt-Jakob disease
    Yuji Mizuno
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Neurosci Lett 366:144-7. 2004
    ..These findings could suggest that ballooned neurons are being reactivated to promote survival, although the role of nestin is not clear...
  8. ncbi request reprint Expression of nestin in Purkinje cells in patients with Creutzfeldt-Jakob disease
    Yuji Mizuno
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Neurosci Lett 352:109-12. 2003
    ..Our findings suggest that nestin is strongly expressed in Purkinje cells in pathologically advanced CJD and show the possibility that Purkinje cells are being reactivated to promote survival...
  9. ncbi request reprint Vacuole-creating protein in neurodegenerative diseases in humans
    Yuji Mizuno
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Neurosci Lett 343:77-80. 2003
    ..The elucidation of an association between VCP and these degenerative proteins will provide an important clue for understanding common mechanisms underlying neurodegenerative diseases...
  10. pmc Beta-synemin expression in cardiotoxin-injected rat skeletal muscle
    Yuji Mizuno
    Department of Neurology, Gunma University Graduate School of Medicine, Showa, Maebashi, Gunma, Japan
    BMC Musculoskelet Disord 8:40. 2007
    ..The aim of our study is to show whether each alpha-dystrobrevin isoform has the same affinity for beta-synemin or whether one of the isoforms preferentially functions with beta-synemin in muscle...
  11. doi request reprint Peripherin partially localizes in Bunina bodies in amyotrophic lateral sclerosis
    Yuji Mizuno
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    J Neurol Sci 302:14-8. 2011
    ..Furthermore, following cystatin C and transferrin, peripherin is the third most prevalent protein that partially localizes in Bunina bodies...
  12. pmc Expression of synemin in the mouse spinal cord
    Yuji Mizuno
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showa, Maebashi, Gunma 371 8511, Japan
    Muscle Nerve 39:634-41. 2009
    ..These results show that neurons that express synemin also express tryptophan hydroxylase-1, a marker of serotoninergic nerve fibers. Muscle Nerve, 2009...
  13. pmc Genomic organization and single-nucleotide polymorphism map of desmuslin, a novel intermediate filament protein on chromosome 15q26.3
    Y Mizuno
    Howard Hughes Medical Institute, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    BMC Genet 2:8. 2001
    ..As a muscle-specific intermediate filament protein, desmuslin is also a candidate for myopathies of unknown etiology...
  14. doi request reprint Anterior horn cells with abnormal TDP-43 immunoreactivities show fragmentation of the Golgi apparatus in ALS
    Yukio Fujita
    Department of Neurology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    J Neurol Sci 269:30-4. 2008
    ..These results suggest that neurons with abnormal TDP-43 immunoreactivities are associated with dysfunction of the secretory pathway in motor neurons...
  15. ncbi request reprint Pathology of the inferior olivary nucleus in patients with multiple system atrophy
    Atsushi Sakurai
    Department of Neurology, Gunma University School of Medicine, 3 39 15, Showa machi, Maebashi, 371 8511, Japan
    Acta Neuropathol 103:550-4. 2002
    ..This study is also consistent with the conclusion that lesions of the ION may not always reflect changes of transsynaptic degeneration secondary to Purkinje cell loss...
  16. doi request reprint Optineurin in neurodegenerative diseases
    Tenshi Osawa
    Department of Neurology, Gunma University Graduate School of Medicine, Gunma, Japan
    Neuropathology 31:569-74. 2011
    ..This study indicates that optineurin is widely distributed in neurodegenerative conditions; however, its significance is obscure...
  17. doi request reprint Pathology of protein synthesis and degradation systems in ALS
    Koichi Okamoto
    Department of Neurology, Gunma University Graduate School of Medicine, Maebashi, Japan
    Neuropathology 30:189-93. 2010
    ..Here, we present our data and discuss the main morphological abnormalities detected in the anterior horn cells of ALS patients...
  18. ncbi request reprint Increased neuronal expression of alpha B-crystallin in human olivary hypertrophy
    Kazuko Fukushima
    Department of Neurology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Neuropathology 26:196-200. 2006
    ..The accumulation of alpha B-crystallin and HSP 27 may represent responses to pathologic conditions...
  19. doi request reprint Morphological changes of Golgi apparatus in adult rats after facial nerve injuries
    Yukio Fujita
    Department of Neurology, Gunma University Graduate School of Medicine, Gunma, Japan
    Neuropathology 31:42-7. 2011
    ..These results suggest that there may be a similar cascade leading to motor neuron death in rats after avulsion, and ALS and GA observed in rats after axotomy may not be related to neuronal death...
  20. ncbi request reprint Bunina bodies in amyotrophic lateral sclerosis
    Koichi Okamoto
    Department of Neurology, Gunma University Graduate School of Medicine, Gunma, Japan
    Neuropathology 28:109-15. 2008
    ..Although the nature and significance of Bunina bodies in ALS are not yet clear, the bodies may be abnormal accumulations of unknown proteinous materials...
  21. ncbi request reprint PARK6-linked autosomal recessive early-onset parkinsonism in Asian populations
    Y Hatano
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Neurology 63:1482-5. 2004
    ..88 at D1S2732. The results indicate worldwide distribution of PARK6-linked parkinsonism...
  22. pmc Desmuslin, an intermediate filament protein that interacts with alpha -dystrobrevin and desmin
    Y Mizuno
    Howard Hughes Medical Institute Division of Genetics, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:6156-61. 2001
    ..Our findings suggest that DMN may serve as a direct linkage between the extracellular matrix and the Z-discs (through plectin) and may play an important role in maintaining muscle cell integrity...
  23. doi request reprint Clinicopathologic study of a SNCA gene duplication patient with Parkinson disease and dementia
    T Obi
    Department of Neurology, Shizuoka Institute of Epilepsy and Neurological Disorders, Tokyo, Japan
    Neurology 70:238-41. 2008
  24. ncbi request reprint Structural organization and chromosomal localization of the human nuclear gene (NDUFV2) for the 24-kDa iron-sulfur subunit of complex I in mitochondrial respiratory chain
    N Hattori
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 216:771-7. 1995
    ..The sequences matching completely with the NRF-1 binding site and Mt elements were not identified in the flanking region. This gene was assigned to human chromosome 18 at region p11.3, by fluorescent in situ hybridization...
  25. ncbi request reprint Clinicogenetic study of PINK1 mutations in autosomal recessive early-onset parkinsonism
    Y Li
    Department of Neurology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo, Tokyo 113 0033, Japan
    Neurology 64:1955-7. 2005
    ..Clinically, the patients with the deletion had dementia. Thus, early-onset PD with dementia may be considered PINK1-linked parkinsonism. Furthermore, patients with PINK1 mutations form 8.9% of parkin- and DJ-1-negative ARPD families...
  26. ncbi request reprint Beta-sarcoglycan (A3b) mutations cause autosomal recessive muscular dystrophy with loss of the sarcoglycan complex
    C G Bonnemann
    Howard Hughes Medical Institute Division of Genetics, Children s Hospital, Boston, Massachusetts 02115, USA
    Nat Genet 11:266-73. 1995
    ..Thus secondary destabilization of the sarcoglycan complex may be an important pathophysiological event in ARMD...
  27. pmc Localization of a gene for an autosomal recessive form of juvenile Parkinsonism to chromosome 6q25.2-27
    H Matsumine
    Department of Neurology, Juntendo University School of Medicine, Bunkyo, Tokyo, Japan
    Am J Hum Genet 60:588-96. 1997
    ..Delineation of the AR-JP gene will be an important step toward our understanding of the molecular mechanism underlying selective degeneration of the nigral neurons...
  28. ncbi request reprint Autosomal recessive juvenile parkinsonism: a key to understanding nigral degeneration in sporadic Parkinson's disease
    N Hattori
    Department of Neurology, Juntendo University School of Medicine, Bunkyo, Tokyo, Japan
    Neuropathology 20:S85-90. 2000
    ..Our findings should enhance the exploration of the mechanisms of neuronal death in PD as well as other neurodegenerative disorders of which variable inclusion bodies are observed...
  29. ncbi request reprint Polymorphism of the lipoprotein lipase gene and risk of atherothrombotic cerebral infarction in the Japanese
    Y Shimo-Nakanishi
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Stroke 32:1481-6. 2001
    ..We investigated whether these polymorphisms are associated with increased risk of ischemic cerebrovascular disease (CVD)...
  30. ncbi request reprint Pathological analysis of muscle hypertrophy and degeneration in muscular dystrophy in gamma-sarcoglycan-deficient mice
    Toshikuni Sasaoka
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neuromuscul Disord 13:193-206. 2003
    ..The muscle pathology became more 'dystrophic' in mice over 1 year of age when there was a marked variation in fiber size with interstitial fibrosis...
  31. ncbi request reprint Paraoxonase gene Gln192Arg (Q192R) polymorphism is associated with coronary artery spasm
    Teruhiko Ito
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Hum Genet 110:89-94. 2002
    ..01). Thus, there is a significant association between the PON1-192R allele and coronary spasm; the PON1-192R allele may play an important role in the genesis of coronary spasm, probably by attenuating the suppression of oxidative stress...
  32. ncbi request reprint Inhibitory effect of natriuretic peptides on aldosterone synthase gene expression in cultured neonatal rat cardiocytes
    Teruhiko Ito
    Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto, Japan
    Circulation 107:807-10. 2003
    ..We hypothesized that natriuretic peptides reduce the expression of CYP11B2 mRNA in the heart...
  33. ncbi request reprint Molecular and cell biology of the sarcoglycan complex
    Eijiro Ozawa
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Ogawahigashi cho, Kodaira, Tokyo, Japan
    Muscle Nerve 32:563-76. 2005
    ..Finally, we stress that the SG complex cannot work by itself and works in a larger complex system, called the transverse fixation system, which forms an array of molecules responsible for various muscular dystrophies...
  34. ncbi request reprint Predominant effect of A-type natriuretic peptide on reduction of oxidative stress during the treatment of patients with heart failure
    Makoto Shono
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Circ J 71:1040-6. 2007
    ....