Hirokazu Kimura

Summary

Affiliation: Gunma Prefectural Cardiovascular Center
Country: Japan

Publications

  1. ncbi Toxicity and roles of reactive oxygen species
    H Kimura
    Gunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi, Gunma, Japan
    Curr Drug Targets Inflamm Allergy 4:489-95. 2005
  2. ncbi Release of IL-4 and IL-5 from human peripheral blood mononuclear cells co-cultured with Japanese cedar pollen antigen in vitro
    H Kimura
    Gunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi, Gunma, 371 0052, Japan
    Cell Biol Int 25:841-4. 2001
  3. ncbi Tuberculosis-like peritonitis due to an atypical Mycobacterium infection in a Japanese woman
    Hirokazu Kimura
    Gunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi shi, Gunma 371 0052, Japan
    Jpn J Infect Dis 59:189-91. 2006
  4. ncbi Sulfonated human immunoglobulin enhances CD16-linked CD11b expression on human neutrophils
    Hirokazu Kimura
    Gunma Prefectural Institute of Public Health and Environmental Sciences, 378, Kamioki, Maebashi, Gunma 371 0052, Japan
    Cell Biol Int 27:913-9. 2003
  5. ncbi Superoxide radical-scavenging effects from polymorphonuclear leukocytes and toxicity in human cell lines of newly synthesized organic selenium compounds
    Hiroyuki Tsukagoshi
    Gunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi, Japan
    FEBS J 274:6046-54. 2007
  6. doi Different cytokine profile and eosinophil activation are involved in rhinovirus- and RS virus-induced acute exacerbation of childhood wheezing
    Masahiko Kato
    Departments of Allergy and Immunology, Gunma Children s Medical Center, 779 Shimohakoda, Hokkitsu machi, Shibukawa, Gunma, Japan
    Pediatr Allergy Immunol 22:e87-94. 2011
  7. ncbi Sequence and phylogenetic analysis of the nucleoprotein (N) gene in measles viruses prevalent in Gunma, Japan, in 2007
    Yukio Morita
    Gunma Prefectural Institute of Public Health and Environmental Sciences, Gunma, Japan
    Jpn J Infect Dis 60:402-4. 2007
  8. doi Effects of respiratory syncytial virus infection and major basic protein derived from eosinophils in pulmonary alveolar epithelial cells (A549)
    Taisei Ishioka
    Gunma Prefectural Institute of Public Health and Environmental Sciences, 378 Kamioki machi, Maebashi shi, Gunma, Japan
    Cell Biol Int 35:467-74. 2011
  9. ncbi Superoxide anion-scavenging effect of 2-amino-1,3-selenazoles
    Akihiro Sekiguchi
    Gunma Industrial Technology Center, Gunma, Japan
    Chem Pharm Bull (Tokyo) 53:1439-42. 2005
  10. doi Interferon-gamma enhances human eosinophil effector functions induced by granulocyte-macrophage colony-stimulating factor or interleukin-5
    Takafumi Yamaguchi
    Gunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi, Gunma, Japan
    Immunol Lett 118:88-95. 2008

Collaborators

Detail Information

Publications69

  1. ncbi Toxicity and roles of reactive oxygen species
    H Kimura
    Gunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi, Gunma, Japan
    Curr Drug Targets Inflamm Allergy 4:489-95. 2005
    ..In this review, we have focused on and described the basic properties, toxicity, and roles of ROS...
  2. ncbi Release of IL-4 and IL-5 from human peripheral blood mononuclear cells co-cultured with Japanese cedar pollen antigen in vitro
    H Kimura
    Gunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi, Gunma, 371 0052, Japan
    Cell Biol Int 25:841-4. 2001
    ..These results suggest that PBMCs were more likely to release IL-4 and IL-5 in the presence of JCP pollinosis...
  3. ncbi Tuberculosis-like peritonitis due to an atypical Mycobacterium infection in a Japanese woman
    Hirokazu Kimura
    Gunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi shi, Gunma 371 0052, Japan
    Jpn J Infect Dis 59:189-91. 2006
    ..Genetic analysis of the biopsy specimens suggested an AM infection. Thus, we concluded that peritonitis in humans can be caused by some AM species as well as by Mycobacterium tuberculosis complex...
  4. ncbi Sulfonated human immunoglobulin enhances CD16-linked CD11b expression on human neutrophils
    Hirokazu Kimura
    Gunma Prefectural Institute of Public Health and Environmental Sciences, 378, Kamioki, Maebashi, Gunma 371 0052, Japan
    Cell Biol Int 27:913-9. 2003
    ..CD11b induction was inhibited by dexamethasone and by anti-CD16 antibody. These in vitro results suggest that aggregations and enhancement of CD11b on neutrophils by SHIG may induce excessive inflammatory responses in vivo...
  5. ncbi Superoxide radical-scavenging effects from polymorphonuclear leukocytes and toxicity in human cell lines of newly synthesized organic selenium compounds
    Hiroyuki Tsukagoshi
    Gunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi, Japan
    FEBS J 274:6046-54. 2007
    ..Selenoureas acted as effective antioxidants and showed low toxicity in some human cells. Thus, these compounds might be new candidates as antioxidative substances...
  6. doi Different cytokine profile and eosinophil activation are involved in rhinovirus- and RS virus-induced acute exacerbation of childhood wheezing
    Masahiko Kato
    Departments of Allergy and Immunology, Gunma Children s Medical Center, 779 Shimohakoda, Hokkitsu machi, Shibukawa, Gunma, Japan
    Pediatr Allergy Immunol 22:e87-94. 2011
    ..Different cytokine profile and eosinophil activation might be involved in rhinovirus- and RS virus-induced acute exacerbation of childhood wheezing...
  7. ncbi Sequence and phylogenetic analysis of the nucleoprotein (N) gene in measles viruses prevalent in Gunma, Japan, in 2007
    Yukio Morita
    Gunma Prefectural Institute of Public Health and Environmental Sciences, Gunma, Japan
    Jpn J Infect Dis 60:402-4. 2007
    ..The results suggest that highly homologous measles viruses may be associated with outbreaks of measles in Gunma, Japan...
  8. doi Effects of respiratory syncytial virus infection and major basic protein derived from eosinophils in pulmonary alveolar epithelial cells (A549)
    Taisei Ishioka
    Gunma Prefectural Institute of Public Health and Environmental Sciences, 378 Kamioki machi, Maebashi shi, Gunma, Japan
    Cell Biol Int 35:467-74. 2011
    ....
  9. ncbi Superoxide anion-scavenging effect of 2-amino-1,3-selenazoles
    Akihiro Sekiguchi
    Gunma Industrial Technology Center, Gunma, Japan
    Chem Pharm Bull (Tokyo) 53:1439-42. 2005
    ..03 microM and 92.6 microM, respectively. Thus, these compounds acted in vitro as effective O2- scavengers...
  10. doi Interferon-gamma enhances human eosinophil effector functions induced by granulocyte-macrophage colony-stimulating factor or interleukin-5
    Takafumi Yamaguchi
    Gunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi, Gunma, Japan
    Immunol Lett 118:88-95. 2008
    ..In conclusion, IFN-gamma might upregulate ERK, p38, or JNK/ATF-2 phosphorylation induced by GM-CSF or IL-5, leading to enhanced cytokine-induced eosinophil superoxide generation and degranulation...
  11. ncbi Isolation and phylogenetic analysis of arcobacter spp. in ground chicken meat and environmental water in Japan and Thailand
    Yukio Morita
    Gunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi, Gunma 371 0052, Japan
    Microbiol Immunol 48:527-33. 2004
    ..In both countries, the results suggested that chicken and environmental water were highly contaminated with a genetically diverse population of Arcobacter...
  12. ncbi Selenoureas and thioureas are effective superoxide radical scavengers in vitro
    Hitoe Takahashi
    Gunma Industrial Technology Center, 884 1 Kamesato, Maebashi, Gunma, 379 2147, Japan
    Life Sci 76:2185-92. 2005
    ..A possibility that selenoureas could use it as a new superoxide anion-scavenging substance from the result of this research became clear...
  13. ncbi Inhibition of human eosinophil activation by a cysteinyl leukotriene receptor antagonist (pranlukast; ONO-1078)
    Masato Suzuki
    Department of Pediatrics, Gunma University School of Medicine, Maebashi, Gunma, Japan
    J Asthma 40:395-404. 2003
    ....
  14. ncbi Genetic analysis of attachment glycoprotein (G) gene in new genotype ON1 of human respiratory syncytial virus detected in Japan
    Hiroyuki Tsukagoshi
    Gunma Prefectural Institute of Public Health and Environmental Sciences, 378 Kamioki machi, Maebashi shi, Gunma, 371 0052
    Microbiol Immunol 57:655-9. 2013
    ..The p-distance was short and no positive selection site was found in the present strains. These results suggested that a new genotype ON1 of RSV-A emerged approximately10 years ago and spread to some countries with a high evolution rate...
  15. ncbi Distinct isoforms of protein kinase C are involved in human eosinophil functions induced by platelet-activating factor
    Takumi Takizawa
    Department of Pediatrics, Gunma University School of Medicine, Maebashi, Gunma, Japan
    Int Arch Allergy Immunol 131:15-9. 2003
    ..We have therefore investigated whether or not the PKC isoforms involved in PAF-induced CD11b expression and superoxide generation were different...
  16. ncbi Superoxide radical generation and Mn- and Cu-Zn superoxide dismutases activities in human leukemic cells
    Masahiko Kato
    Department of Pediatrics, Gunma University School of Medicine, Maebashi, Gunma, Japan
    Hematol Oncol 21:11-6. 2003
    ..These results suggest that except in M5b cells, decreased O(2) (-) production may contribute to susceptibility to infections in AML patients. Decreased Mn-SOD activity in AML cells may predispose them to oxidative stress...
  17. ncbi Selenocarbamates are effective superoxide anion scavengers in vitro
    Hitoe Takahashi
    Gunma Industrial Technology Center, 884 1 Kamesato, Maebashi, Gunma 379 2147, Japan
    Eur J Pharm Sci 24:291-5. 2005
    ..Thus, these compounds acted in vitro as effective and potentially useful O(2)*- scavengers...
  18. pmc Genetic analysis of non-hydrogen sulfide-producing Salmonella enterica serovar typhimurium and S. enterica serovar infantis isolates in Japan
    Chieko Sakano
    Gunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi shi, Gunma, Japan
    J Clin Microbiol 51:328-30. 2013
    ..The lack of production of H(2)S might lead to the incorrect identification of S. enterica isolates carrying antimicrobial resistance genes...
  19. doi Release of cytokines/chemokines and cell death in UVB-irradiated human keratinocytes, HaCaT
    Masakazu Yoshizumi
    Gunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi, Gunma, Japan
    Cell Biol Int 32:1405-11. 2008
    ..These results suggest that UVB irradiation-induced the release of several cytokines/chemokines and led to cell death in human keratinocytes. UV exposure may be associated with multiple physiological events in the human skin...
  20. ncbi Genetic diversity of the dnaJ gene in the Mycobacterium avium complex
    Yukio Morita
    Gunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi, Gunma, Japan
    J Med Microbiol 53:813-7. 2004
    ..Analysis of the dnaJ gene in MAC may be useful in epidemiological studies...
  21. ncbi Dual signaling and effector pathways mediate human eosinophil activation by platelet-activating factor
    Masahiko Kato
    Department of Allergy, Gunma Children s Medical Center, Hokkitsu, Gunma, Japan
    Int Arch Allergy Immunol 134:37-43. 2004
    ..This activation of two different G proteins by the eosinophil PAF receptor may explain the strong and diverse biological responses of human eosinophils to PAF...
  22. ncbi Detection and phylogenetic analysis of norovirus in Corbicula fluminea in a freshwater river in Japan
    Mika Saitoh
    Gunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi, Gunma, Japan
    Microbiol Immunol 51:815-22. 2007
    ..In addition, more than 10(4) copies of the NoV genome were detected in 2 of 35 samples. These results suggest that the freshwater bivalve C. fluminea is a reservoir for NoVs, similar to seawater bivalves such as oysters...
  23. doi Molecular evolution of HA1 in influenza A (H3N2) viruses isolated in Japan from 1989 to 2006
    Mika Saitoh
    Gunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi, Japan
    Intervirology 51:377-84. 2008
    ....
  24. pmc Relationships between Cytokine Profiles and Signaling Pathways (IκB Kinase and p38 MAPK) in Parainfluenza Virus-Infected Lung Fibroblasts
    Masakazu Yoshizumi
    Gunma Prefectural Institute of Public Health and Environmental Sciences Maebashi shi, Gunma, Japan
    Front Microbiol 1:124. 2010
    ..Overproduction and imbalance of these cytokines may be partially associated with the pathophysiology of virus-induced asthma...
  25. ncbi Triplex real-time polymerase chain reaction assay for detection and quantification of norovirus (GI and GII) and sapovirus
    Shoichi Niwa
    Gunma Prefectural Institute of Public Health and Environmental Sciences, 378 Kamioki machi, Maebashi shi, Gunma, 371 0052
    Microbiol Immunol 58:68-71. 2014
    ..The limit of detection was 10(2) copies/assay. The quantitative value was comparable with that of monoplex real-time PCR of stool samples. Our triplex real-time PCR is useful for detection of NoV and SaV infections. ..
  26. ncbi Phylogenetic analysis of envelope glycoprotein (E1) gene of rubella viruses prevalent in Japan in 2004
    Mika Saitoh
    Gunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi, Gunma 371 0052, Japan
    Microbiol Immunol 50:179-85. 2006
    ..The results suggest that the rubella viruses (RV) prevalent in certain areas of Japan in 2004 were highly homologous and were closely related with Japanese vaccine strain...
  27. ncbi Detection and sequence analysis of DNA polymerase and major envelope protein genes in koi herpesviruses derived from Cyprinus carpio in Gunma prefecture, Japan
    Taisei Ishioka
    Gunma Prefectural Institute of Public Health and Environmental Sciences, 378 Kamioki, Maebashi, Gunma 371 0052, Japan
    Vet Microbiol 110:27-33. 2005
    ..The results suggested that KHV strains derived from carps in our prefecture were closely related genetically to the other KHV strains...
  28. ncbi An imported dengue fever case by dengue virus 3 (DENV-3) infection in Gunma, Japan
    Yukio Morita
    Gunma Prefectural Institute of Public Health and Environmental Sciences, Gunma, Japan
    Jpn J Infect Dis 61:90-2. 2008
  29. ncbi Serum procalcitonin concentration in patients with Kawasaki disease
    Yasunori Okada
    Department of Pediatrics, Gunma University School of Medicine, Showa machi 3 39 22, Maebashi, Gunma 371 8511, Japan
    J Infect 48:199-205. 2004
    ..Procalcitonin (PCT) is a new parameter of inflammation, the clinical usefulness of which is currently being evaluated...
  30. ncbi Prevalence of hepatitis E virus (HEV) infection in wild boars (Sus scrofa leucomystax) and pigs in Gunma Prefecture, Japan
    Chieko Sakano
    Gunma Prefectural Meat Inspection Laboratory, 305 7 Higoshi, Tamamura, Sawa, Gunma, Japan
    J Vet Med Sci 71:21-5. 2009
    ..In Gunma Prefecture, HEV is highly prevalent and widespread, and uncooked wild boar and pig meat may have the potential to transmit HEV to humans...
  31. ncbi Role of protein kinase C in eosinophil function
    Takafumi Yamaguchi
    Gunma Prefectural Institute of Public Health and Environmental Sciences, Gunma, Japan
    Allergol Int 55:245-52. 2006
    ..However, the role of PKCs in eosinophil functions has been not wholly understood. In this review, we have focused upon and summarized the current knowledge regarding the role of PKC isoforms in eosinophil functions...
  32. ncbi Increased superoxide radicals generation from alveolar macrophages in immature guinea-pigs
    Masahiko Kato
    Department of Pediatriacs, Gunma University School of Medicine, Maebashi, Gunma, 371 8511, Japan
    Cell Biol Int 26:829-32. 2002
    ..5 micro g/ml). The results suggest that alveolar macrophages from immature animals are far more potent O-2 generators than the same cells of adult animals...
  33. pmc Molecular evolution of hemagglutinin (H) gene in measles virus genotypes D3, D5, D9, and H1
    Mika Saitoh
    Gunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi shi, Gunma, Japan
    PLoS ONE 7:e50660. 2012
    ..The results suggested that the prevalent Asian MeV genotypes were generated over approximately 30-40 years and H protein was well conserved...
  34. ncbi Role of eosinophils and their clinical significance in allergic inflammation
    Masahiko Kato
    Gunma Children s Medical Center, Department of Allergy and Immunology, Gunma Children s Medical Center, 779 Shimohakoda, Hokkitsu, Gunma 377 8577, Japan
    Expert Rev Clin Immunol 2:121-33. 2006
    ..Finally, the authors will demonstrate that eosinophils have the potential for not only playing detrimental roles but also beneficial ones...
  35. pmc An atypical protein kinase C, PKC zeta, regulates human eosinophil effector functions
    Masahiko Kato
    Department of Allergy and Immunology, Gunma Children s Medical Centere, Hokkitsu, Japan
    Immunology 116:193-202. 2005
    ..Thus, the atypical PKC zeta regulates human eosinophil adhesion and effector functions...
  36. ncbi Tertiary selenoamide compounds are useful superoxide radical scavengers in vitro
    Hitoe Takahashi
    Gunma Industrial Technology Center, 884 1 Kamesato, Maebashi, Gunma 379 2147, Japan
    Eur J Pharm Sci 23:207-11. 2004
    ..The results suggest that tertiary selenoamide compounds are useful scavengers of superoxide radicals...
  37. ncbi Lysophosphatidylethanolamine in Grifola frondosa as a neurotrophic activator via activation of MAPK
    Atsuyoshi Nishina
    Gunma Industrial Technology Center, 884 1 Kamesato, Maebashi, Gunma 379 2147, Japan
    J Lipid Res 47:1434-43. 2006
    ..This study has clarified for the first time the involvement of the MAPK signal cascade in LPE actions...
  38. pmc Detailed genetic analysis of hemagglutinin-neuraminidase glycoprotein gene in human parainfluenza virus type 1 isolates from patients with acute respiratory infection between 2002 and 2009 in Yamagata prefecture, Japan
    Katsumi Mizuta
    Yamagata Prefectural Institute of Public Health, 1 6 6 Toka machi, Yamagata shi, Yamagata 990 0031, Japan
    Virol J 8:533. 2011
    ....
  39. ncbi Proinflammatory cytokinemia associated with transient myeloproliferative disorder in down syndrome
    Akira Shimada
    Gunma Children s Medical Center, Gunma, Japan
    Biol Neonate 85:167-72. 2004
    ..Sustained cytokinemia is likely to participate in TMD pathophysiology, and very high serum concentrations might predict a poor outcome...
  40. ncbi Respiratory syncytial virus enhances the expression of CD11b molecules and the generation of superoxide anion by human eosinophils primed with platelet-activating factor
    Atsushi Tachibana
    Department of Pediatrics, Gunma University School of Medicine, Gunma, Japan
    Intervirology 45:43-51. 2002
    ..Human respiratory syncytial virus (RSV) infection in infancy and early childhood causes acute bronchiolitis and exacerbates bronchial asthma. Eosinophil infiltration may contribute to airway obstruction in RSV infection...
  41. ncbi Food poisoning outbreak caused by norovirus GII/4 in school lunch, Tochigi prefecture, Japan
    Teruko Oogane
    Tochigi Prefectural Institute of Public Health, Tochigi 329 1196, Japan
    Jpn J Infect Dis 61:423-4. 2008
  42. ncbi Inhibition of protein kinases A and C demonstrates dual modes of response in human eosinophils stimulated with platelet-activating factor
    Takumi Takizawa
    Department of Pediatrics, Gunma University School of Medicine, 3 39 22 Showa machi Maebashi, Gunma 371 8511, Japan
    J Allergy Clin Immunol 110:241-8. 2002
    ..However, intracellular signaling mechanisms in eosinophils involving the PAF receptor are incompletely understood...
  43. pmc Detection, quantitation, and phylogenetic analysis of noroviruses in Japanese oysters
    Tomoko Nishida
    Yamaguchi Prefectural Research Institute of Public Health, Yamaguchi, Japan
    Appl Environ Microbiol 69:5782-6. 2003
    ..The results suggested that about 10% of Japanese oysters intended for raw consumption harbored NVs, and more than 50% of those oysters in which NVs were detected had a large amount...
  44. ncbi Differential role of an atypical protein kinase C, PKC zeta, in regulation of human eosinophil and neutrophil functions
    Masahiko Kato
    Department of Allergy and Immunology, Gunma Children s Medical Center, Hokkitsu, Japan
    Int Arch Allergy Immunol 137:27-34. 2005
    ..Here we compared the influence of PKC zeta on the function of human eosinophils and neutrophils...
  45. ncbi Serotypes, antimicrobial susceptibility, and gyr A gene mutation of Campylobacter jejuni isolates from humans and chickens in Thailand
    Sumalee Boonmar
    Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand
    Microbiol Immunol 51:531-7. 2007
    ..All quinolone-resistant strains contained a mutation in the gyrA gene (T(86)-->I(86)), suggesting that the strains were already widespread in Thailand...
  46. pmc Human sapovirus in clams, Japan
    Grant S Hansman
    National Institute of Infectious Diseases, Tokyo, Japan
    Emerg Infect Dis 13:620-2. 2007
    ..Closely matching sequences have been detected in stool specimens from patients with gastroenteritis in Japan, which indicates a possible food-to-human transmission link...
  47. ncbi Cellular adhesion is required for effector functions of human eosinophils via G-protein coupled receptors
    Toru Fujiu
    Department of Pediatrics, Gunma University School of Medicine, Japan
    Ann Allergy Asthma Immunol 89:90-8. 2002
    ..Chemoattractants, including platelet-activating factor (PAF) and complement component 5a (C5a), induce eosinophil infiltration and promote eosinophil effector functions...
  48. ncbi Platelet-activating factor activates two distinct effector pathways in human eosinophils
    Masahiko Kato
    Department of Pediatrics, Gunma University School of Medicine, Japan
    J Immunol 169:5252-9. 2002
    ..These two activation pathways may explain the eosinophils' strong and diverse biological responses to PAF...
  49. ncbi Phylogenetic analysis of nucleoprotein (N) gene of measles viruses prevalent in Okinawa, Japan, during 2003-2007
    Katsuya Taira
    Department of Biological Sciences, Okinawa Prefectural Institute of Health and Environment, Okinawa 910 1201, Japan
    Jpn J Infect Dis 61:248-50. 2008
  50. ncbi Fenoterol inhibits superoxide anion generation by human polymorphonuclear leukocytes via beta-adrenoceptor-dependent and -independent mechanisms
    Zafar Nazir Mirza
    Department of Pediatrics, Gunma University School of Medicine, Japan
    Ann Allergy Asthma Immunol 88:494-500. 2002
    ..Beta2-adrenoceptor agonists, used widely as bronchodilator in treating bronchial asthma, may have anti-inflammatory activity...
  51. ncbi [Cost of HIV treatment in highly active antiretroviral therapy in Japan]
    Hirokazu Kimura
    Department of Public Health, Yokohama City University School of Medicine
    Nihon Rinsho 60:813-6. 2002
    ..Compared with cost estimates in 1995, the outpatient costs were 2.7 to 8.6 times and the inpatient cost increased by 25%...
  52. ncbi Temporal alterations in concentrations of sera cytokines/chemokines in sepsis due to group B streptococcus infection in a neonate
    Kaoru Okazaki
    Divisions of Neonatology, Tokyo Metropolitan Hachioji Children s Hospital, Tokyo 193 0931, Japan
    Jpn J Infect Dis 61:382-5. 2008
    ..At birth, the concentrations of different cytokines/chemokines increased and that of granulocyte colony-stimulating factor remained high. Thus, these cytokines/chemokines might be associated with the pathophysiology of GBS infection...
  53. ncbi [Drinking behavior of female nursing students and stress factors related problem drinking]
    Yukie Kumagai
    Kanagawa Prefectural College of Nursing and Medical Technology, 1 5 1 Nakao, Asahi ku, Yokohama, Kanagawa 241 0815, Japan
    Nihon Arukoru Yakubutsu Igakkai Zasshi 37:57-66. 2002
    ....
  54. ncbi Analysis of monthly isolation of respiratory viruses from children by cell culture using a microplate method: a two-year study from 2004 to 2005 in yamagata, Japan
    Katsumi Mizuta
    Department of Microbiology, Yamagata Prefectural Institute of Public Health, Yamagata 990 0031, Japan
    Jpn J Infect Dis 61:196-201. 2008
    ..In conclusion, we verified that the modified microplate method was able to clarify the etiology and epidemiology of numerous viruses isolated from children with ARI...
  55. ncbi Keratoconjunctivitis caused by echovirus type 13 in Japanese children
    Hirokazu Kimura
    Pediatr Infect Dis J 22:758-9. 2003
  56. ncbi Elevation of cytokine concentrations in asphyxiated neonates
    Kaoru Okazaki
    Tokyo Metropolitan Hachioji Children s Hospital, Hachioji, and Division of Neonatology, Perinatal Center, Toho University School of Medicine, Tokyo, Japan
    Biol Neonate 89:183-9. 2006
    ..Various cytokines are reportedly associated with many neonatal diseases. Asphyxia is considered to result in ischemia-reperfusion injuries and induces abnormal inflammatory responses involving excessive cytokine production...
  57. ncbi A highly effective method for removing suspended poliovirus from water using a positively-charged carbon felt electrode
    Yasuhito Kondo
    Ecology and Energy Systems Development Center, SANYO Electric, Oizumi, Gunma 370 0596, Japan
    Microbiol Immunol 48:599-605. 2004
    ..Virus elimination was dependent on electric current and time. Thus, the positively-charged carbon felt electrode effectively adsorbed polioviruses. The system may prove applicable to the elimination of certain viruses from water...
  58. ncbi Bis-(2-amino-5-selenazoyl) ketone as a superoxide anion-scavenger
    Akihiro Sekiguchi
    Gunma Industrial Technology Center, Japan
    Biol Pharm Bull 29:1404-7. 2006
    ..1 microM. Thus, bis[2-dimethylamino-5-(1,3-selenazolyl)] ketone acted in vitro as effective and potentially useful O(2)(-) scavenger...
  59. pmc Substance use and sexual behaviours of Japanese men who have sex with men: a nationwide internet survey conducted in Japan
    Yasuharu Hidaka
    Department of Global Health and Socio Epidemiology, Kyoto University School of Public Health Yoshidakonoe cho, Sakyo ku, Kyoto 606 8501, Japan
    BMC Public Health 6:239. 2006
    ..This Internet survey explored the extent of substance use and its association with sexual risk behaviours among Japanese MSM...
  60. ncbi Pro-inflammatory cytokinemia is frequently found in Down syndrome patients with hematological disorders
    Akira Shimada
    Department of Hematology Oncology, Gunma Children s Medical Center, 779 Shimohakoda, Hokkitsu, Shibukawa, Gunma 377 8577, Japan
    Leuk Res 31:1199-203. 2007
    ..These abnormal cytokinemia may have a role in the pathophysiology of TAM, MDS and AMKL in DS, especially in liver fibrosis or myelofibrosis...
  61. ncbi Omenn syndrome--review of several phenotypes of Omenn syndrome and RAG1/RAG2 mutations in Japan
    Masahiko Kato
    Department of Allergy and Immunology, Gunma Children s Medical Center, Hokkitsu, Gunma, Japan gcmc pref gunma jp
    Allergol Int 55:115-9. 2006
    ..In this review, we will focus on the variation of several phenotypes of OS...
  62. ncbi Genotyping and quantitation of noroviruses in oysters from two distinct sea areas in Japan
    Tomoko Nishida
    Yamaguchi Prefectural Research Institute of Public Health, Yamaguchi, Japan
    Microbiol Immunol 51:177-84. 2007
    ..These results suggested that NVs obtained from humans and those obtained from oysters showed a potential relationship to each other and that some populations of Japanese oysters accumulated a relatively large number of NVs...
  63. ncbi Isolation of Mycobacterium spp. from milking buffaloes and cattle in Nepal
    Vijay Chandra Jha
    His Majesty s Government of Nepal, Ministry of Agriculture and Cooperatives, Department of Livestock Services, Regional Veterinary Laboratory, Kaski, Pakhara, Nepal
    J Vet Med Sci 69:819-25. 2007
    ..The remaining 23 strains were atypical mycobacteria. A program for the elimination of bovine tuberculosis should be implemented as soon as possible, and the public health education and proper hygienic practices may be required...
  64. ncbi A case of meningoencephalitis associated with G1P[8] rotavirus infection in a Japanese child
    Tamako Goto
    Department of Pediatrics, Jichi Medical School, Yakushiji, Shimotsuke, Japan
    Scand J Infect Dis 39:1067-70. 2007
    ..Substitutions in both the VP4 and VP7 genes were found in the identified strain. A commonly circulating G1P[8] rotavirus with such mutations might be associated with the pathogenesis of CNS complications, including meningoencephalitis...
  65. ncbi Fetal origin of the GATA1 mutation in identical twins with transient myeloproliferative disorder and acute megakaryoblastic leukemia accompanying Down syndrome
    Akira Shimada
    Blood 103:366. 2004
  66. ncbi [Viral food-borne diseases caused by norovirus]
    Osamu Nishio
    Infectious Diseases Surveillance Center, National Institute of Infectious Diseases, Gakuen 4 7 1, Musashimurayama shi, Tokyo 208 0011, Japan
    Shokuhin Eiseigaku Zasshi 46:235-45. 2005
  67. ncbi Atypical mycobacteriosis in pigs in Japan
    Yukio Morita
    Vet Rec 153:220. 2003
  68. doi Serum cytokine and chemokine profiles in neonates with meconium aspiration syndrome
    Kaoru Okazaki
    Division of Neonatology, Tokyo Metropolitan Hachioji Children s Hospital, 4 33 13 Daimachi, Hachioji, Tokyo 193 0931, Japan
    Pediatrics 121:e748-53. 2008
    ..To clarify any such association, we compared various serum cytokine and chemokine profiles in patients with and without meconium aspiration syndrome...
  69. ncbi Numbers of people with HIV/AIDS reported and not reported to surveillance in Japan
    Shuji Hashimoto
    Department of Hygiene, Fujita Health University School of Medicine, 1 98, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    J Epidemiol 14:182-6. 2004
    ..We attempted to estimate the cumulative number of Japanese with HIV, including people with HIV not reported to the surveillance...