Tamotsu Ishizuka

Summary

Affiliation: Gunma University
Country: Japan

Publications

  1. ncbi Sensitized mast cells migrate toward the antigen: a response regulated by p38 mitogen-activated protein kinase and Rho-associated coiled-coil-forming protein kinase
    T Ishizuka
    First Department of Internal Medicine, Gunma University School of Medicine, Faculty of Health Sciences, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan
    J Immunol 167:2298-304. 2001
  2. pmc Prevalence of asthma symptoms based on the european community respiratory health survey questionnaire and FENO in university students: gender differences in symptoms and FENO
    Tamotsu Ishizuka
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi 371 8511, Japan
    Allergy Asthma Clin Immunol 7:15. 2011
  3. ncbi Safety and efficacy of extracorporeal granulocyte and monocyte adsorption apheresis in patients with severe persistent bronchial asthma
    Tamotsu Ishizuka
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, 371 8511, Japan
    Inflammation 29:9-16. 2005
  4. ncbi Resolvin E1: a novel lipid mediator in the resolution of allergic airway inflammation
    Tamotsu Ishizuka
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Expert Rev Clin Immunol 4:669-72. 2008
  5. ncbi Gender and age risks for hoarseness and dysphonia with use of a dry powder fluticasone propionate inhaler in asthma
    Tamotsu Ishizuka
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Allergy Asthma Proc 28:550-6. 2007
  6. ncbi A case of non-specific interstitial pneumonia effectively treated with a combination of prednisolone and colchicine, in which granulation tissue was extensive
    Tamotsu Ishizuka
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Respirology 10:541-4. 2005
  7. ncbi Fatal pneumonia caused by Burkholderia cepacia 9 months after resection of aspergilloma
    Tamotsu Ishizuka
    First Department of Internal Medicine, Gunma University School of Medicine, Showa machi, Maebashi, Japan
    Respirology 8:401-3. 2003
  8. doi CD98 expression is associated with poor prognosis in resected non-small-cell lung cancer with lymph node metastases
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Ann Surg Oncol 16:3473-81. 2009
  9. doi l-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms
    Kyoichi Kaira
    Deparmtent of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma 371 8511, Japan
    Cancer Sci 99:2380-6. 2008
  10. doi Extracellular acidification stimulates IL-6 production and Ca(2+) mobilization through proton-sensing OGR1 receptors in human airway smooth muscle cells
    Isao Ichimonji
    Institute for Molecular and Cellular Regulation, Gunma Univ, Maebashi, Japan
    Am J Physiol Lung Cell Mol Physiol 299:L567-77. 2010

Detail Information

Publications83

  1. ncbi Sensitized mast cells migrate toward the antigen: a response regulated by p38 mitogen-activated protein kinase and Rho-associated coiled-coil-forming protein kinase
    T Ishizuka
    First Department of Internal Medicine, Gunma University School of Medicine, Faculty of Health Sciences, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan
    J Immunol 167:2298-304. 2001
    ..Both p38 MAPK activation and Rho-dependent activation of Rho-associated coiled-coil-forming protein kinase may be required for Fc(epsilon)RI-mediated cell migration...
  2. pmc Prevalence of asthma symptoms based on the european community respiratory health survey questionnaire and FENO in university students: gender differences in symptoms and FENO
    Tamotsu Ishizuka
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi 371 8511, Japan
    Allergy Asthma Clin Immunol 7:15. 2011
    ..abstract:..
  3. ncbi Safety and efficacy of extracorporeal granulocyte and monocyte adsorption apheresis in patients with severe persistent bronchial asthma
    Tamotsu Ishizuka
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, 371 8511, Japan
    Inflammation 29:9-16. 2005
    ..4% after the therapy. This therapy was not harmful for patients with severe persistent asthma. A placebo-controlled study will be desired to evaluate the efficacy of this nonpharmacological strategy accurately...
  4. ncbi Resolvin E1: a novel lipid mediator in the resolution of allergic airway inflammation
    Tamotsu Ishizuka
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Expert Rev Clin Immunol 4:669-72. 2008
    ..RvE1 and its putative receptor, ChemR23, might open a new avenue in the design of resolution-targeted therapies to control bronchial asthma...
  5. ncbi Gender and age risks for hoarseness and dysphonia with use of a dry powder fluticasone propionate inhaler in asthma
    Tamotsu Ishizuka
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Allergy Asthma Proc 28:550-6. 2007
    ..In patients using ICS, especially in women and the elderly patients, who develop hoarseness/dysphonia, it is important to select the most suitable device so that patients can continue ICS therapy comfortably...
  6. ncbi A case of non-specific interstitial pneumonia effectively treated with a combination of prednisolone and colchicine, in which granulation tissue was extensive
    Tamotsu Ishizuka
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Respirology 10:541-4. 2005
    ..This case suggests that the combination of colchicine and corticosteroids may be an effective therapy for non-specific interstitial pneumonia...
  7. ncbi Fatal pneumonia caused by Burkholderia cepacia 9 months after resection of aspergilloma
    Tamotsu Ishizuka
    First Department of Internal Medicine, Gunma University School of Medicine, Showa machi, Maebashi, Japan
    Respirology 8:401-3. 2003
    ..The precise reason that this apparently immunocompetent patient developed B. cepacia pneumonia remains unknown...
  8. doi CD98 expression is associated with poor prognosis in resected non-small-cell lung cancer with lymph node metastases
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Ann Surg Oncol 16:3473-81. 2009
    ..The purpose of this study was to evaluate the prognostic value of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in resectable non-small-cell lung cancer (NSCLC) patients with N1 and N2 nodal involvement...
  9. doi l-type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms
    Kyoichi Kaira
    Deparmtent of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma 371 8511, Japan
    Cancer Sci 99:2380-6. 2008
    ..Moreover, LAT1 expression was significantly correlated with cell proliferation and angiogenesis...
  10. doi Extracellular acidification stimulates IL-6 production and Ca(2+) mobilization through proton-sensing OGR1 receptors in human airway smooth muscle cells
    Isao Ichimonji
    Institute for Molecular and Cellular Regulation, Gunma Univ, Maebashi, Japan
    Am J Physiol Lung Cell Mol Physiol 299:L567-77. 2010
    ..We conclude that extracellular acidification stimulates IL-6 production and Ca(2+) mobilization through proton-sensing OGR1 receptors/G(q/11) proteins in human ASMCs...
  11. ncbi c-Jun N-terminal kinase negatively regulates lipopolysaccharide-induced IL-12 production in human macrophages: role of mitogen-activated protein kinase in glutathione redox regulation of IL-12 production
    Mitsuyoshi Utsugi
    First Department of Internal Medicine, Gunma University Faculty of Medicine, School of Medicine, Maebashi, Japan
    J Immunol 171:628-35. 2003
    ..Our findings indicate that JNK negatively affects LPS-induced IL-12 production from human macrophages, and that glutathione redox regulates LPS-induced IL-12 production through the opposite control of JNK and p38 MAP kinase activation...
  12. ncbi Phase II prospective study of the efficacy of gefitinib for the treatment of stage III/IV non-small cell lung cancer with EGFR mutations, irrespective of previous chemotherapy
    Noriaki Sunaga
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, and Department of Respiratory Medicine, National Nishigunma Hospital, Japan
    Lung Cancer 56:383-9. 2007
    ..The objective of this study was to prospectively evaluate the efficacy of gefitinib in patients with stage III/IV NSCLC whose tumors carried EGFR mutations, irrespective of previous chemotherapy...
  13. doi L-type amino acid transporter 1 expression is a prognostic marker in patients with surgically resected stage I non-small cell lung cancer
    Hisao Imai
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma, Japan
    Histopathology 54:804-13. 2009
    ..To evaluate the prognostic value of L-type amino acid transporter 1 (LAT1) in patients with stage I non-small cell lung cancer (NSCLC)...
  14. ncbi Usefulness of FDG-PET for early prediction of the response to gefitinib in non-small cell lung cancer
    Noriaki Sunaga
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    Lung Cancer 59:203-10. 2008
    ..The present preliminary study suggests that FDG-PET may be able to predict response to gefitinib in the early stage of therapy in patients with advanced NSCLC and may have a potential prognostic role...
  15. doi JNK1 and JNK2 differently regulate IL-12 production in THP-1 macrophage cells
    Mitsuyoshi Utsugi
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Cytokine 51:127-31. 2010
    ....
  16. doi Evaluation of thoracic tumors with (18)F-FMT and (18)F-FDG PET-CT: a clinicopathological study
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Int J Cancer 124:1152-60. 2009
    ..Our results suggest that coexpression of LAT1 and CD98 in addition to cell proliferation and angiogenesis is relavant for the progression and metastasis of lung cancer...
  17. doi Expression of L-type amino acid transporter 1 (LAT1) in neuroendocrine tumors of the lung
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma 371 8511, Japan
    Pathol Res Pract 204:553-61. 2008
    ..The present results suggest that LAT1 may play a significant role in cellular proliferation, lymph node metastasis, and poor outcome in patients with NE tumors of the lung...
  18. doi Phase 2 study of S-1 plus carboplatin in patients with advanced non-small cell lung cancer
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma 371 8511, Japan
    Lung Cancer 68:253-7. 2010
    ..The combination of S-1 plus carboplatin is an active and well-tolerated regimen for the treatment of patients with advanced NSCLC. Further investigations are required to confirm our results in randomized trials...
  19. ncbi Fluorine-18-alpha-methyltyrosine positron emission tomography for diagnosis and staging of lung cancer: a clinicopathologic study
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Clin Cancer Res 13:6369-78. 2007
    ..Tumor uptake of [(18)F]FMT was compared with that of 2-[(18)F]-fluoro-2-deoxy-D-glucose ([(18)F]FDG) and correlated with L-type amino acid transporter 1 (LAT1) expression...
  20. doi Phase I study of oral S-1 plus Cisplatin with concurrent radiotherapy for locally advanced non-small-cell lung cancer
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Int J Radiat Oncol Biol Phys 75:109-14. 2009
    ..To determine the maximum tolerated dose (MTD) and recommended dose (RD) of S-1 in combination with cisplatin and thoracic radiotherapy in patients with unresectable Stage III non-small-cell lung cancer (NSCLC)...
  21. doi 18F-FMT uptake seen within primary cancer on PET helps predict outcome of non-small cell lung cancer
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma, Japan
    J Nucl Med 50:1770-6. 2009
    ..L-[3-(18)F]-alpha-methyl tyrosine ((18)F-FMT) is an amino-acid tracer for PET imaging. We evaluated the prognostic significance of (18)F-FMT PET in patients with non-small cell lung cancer...
  22. doi Assessment of therapy response in lung cancer with ¹⁸F-α-methyl tyrosine PET
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Japan
    AJR Am J Roentgenol 195:1204-11. 2010
    ..PET with a novel tracer, L-[3-¹⁸F]-α-methyl tyrosine (¹⁸F-FMT), has been studied in lung cancer. We evaluated ¹⁸F-FMT PET for therapy response in comparison with ¹⁸F-FDG PET...
  23. doi Correlation of angiogenesis with 18F-FMT and 18F-FDG uptake in non-small cell lung cancer
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunman 371 8511, Japan
    Cancer Sci 100:753-8. 2009
    ..The present study demonstrated that the metabolic activity of primary tumors as evaluated by PET study with 18F-FMT and 18F-FDG is related to tumor angiogenesis and the proliferative activity in NSCLC...
  24. ncbi Epigenetic inactivation of the RAS-effector gene RASSF2 in lung cancers
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    Int J Oncol 31:169-73. 2007
    ..Our results indicate that aberrant methylation of the RASSF2 gene with the subsequent loss of RASSF2 expression plays an important role in the pathogenesis of lung cancers...
  25. doi PI3K p110beta positively regulates lipopolysaccharide-induced IL-12 production in human macrophages and dendritic cells and JNK1 plays a novel role
    Mitsuyoshi Utsugi
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    J Immunol 182:5225-31. 2009
    ..Our findings indicate that PI3K p110beta positively controls LPS-induced IL-12 production through the JNK1-dependent pathway in human macrophages and DCs...
  26. pmc Oncogenic KRAS-induced interleukin-8 overexpression promotes cell growth and migration and contributes to aggressive phenotypes of non-small cell lung cancer
    Noriaki Sunaga
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma, Japan
    Int J Cancer 130:1733-44. 2012
    ....
  27. doi Protective effect of resolvin E1 on the development of asthmatic airway inflammation
    Haruka Aoki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi 371 8511, Japan
    Biochem Biophys Res Commun 400:128-33. 2010
    ..Our results suggest that RvE1 acts on several phases of asthmatic inflammation and may have anti-inflammatory effects on various cell types...
  28. doi Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in stage I pulmonary adenocarcinoma
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma 371 8511, Japan
    Lung Cancer 66:120-6. 2009
    ..The purpose of this study was to evaluate the prognostic value of l-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in patients with stage I pulmonary adenocarcinoma...
  29. doi Glutathione redox regulates TGF-beta-induced fibrogenic effects through Smad3 activation
    Akihiro Ono
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15, Showa machi, Maebashi 371 8511, Japan
    FEBS Lett 583:357-62. 2009
    ..These data indicate that the intracellular glutathione redox status regulates TGF-beta-induced fibrogenic effects through Smad3 activation...
  30. ncbi Glutathione redox regulates airway hyperresponsiveness and airway inflammation in mice
    Yoko Koike
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Am J Respir Cell Mol Biol 37:322-9. 2007
    ....
  31. ncbi Phase I trial of oral S-1 plus gemcitabine in elderly patients with nonsmall cell lung cancer
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma 371 8511, Japan
    Anticancer Drugs 19:289-94. 2008
    ..Objective responses were seen in four patients (response rate, 42.9%). The combination of S-1 plus gemcitabine is a feasible and well-tolerated regimen for the treatment of elderly patients with advanced NSCLC...
  32. doi Lysophosphatidic acid inhibits CC chemokine ligand 5/RANTES production by blocking IRF-1-mediated gene transcription in human bronchial epithelial cells
    Shinichi Matsuzaki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    J Immunol 185:4863-72. 2010
    ..LPA(1) coupled to G(i) and activation of PI3K is required for this unique effect...
  33. doi Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in early stage squamous cell carcinoma of the lung
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma, Japan
    Cancer Sci 100:248-54. 2009
    ..A cooperative expression of LAT 1 and CD98 is a significant pathological factor for predicting the poor prognosis in patients with resectable stage I squamous cell carcinoma of the lung...
  34. ncbi C-Jun-NH2-terminal kinase mediates expression of connective tissue growth factor induced by transforming growth factor-beta1 in human lung fibroblasts
    Mitsuyoshi Utsugi
    First Department of Internal Medicine, Gunma University Faculty of Medicine, School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma, 371 8511, Japan
    Am J Respir Cell Mol Biol 28:754-61. 2003
    ..These results suggest that TGF-beta1-induced CTGF mRNA expression is mediated through the JNK-dependent pathway, whereas p38 MAP kinase and ERK pathways minimally contribute...
  35. ncbi A phase I dose-escalation study of S-1 plus carboplatin in patients with advanced non-small-cell lung cancer
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Japan
    Anticancer Drugs 18:471-6. 2007
    ..Objective responses were seen in four patients (response rate 33%). The combination of S-1 plus carboplatin is a feasible and well-tolerated regimen for the treatment of patients with advanced non-small-cell lung cancer...
  36. doi A phase II study of amrubicin, a synthetic 9-aminoanthracycline, in patients with previously treated lung cancer
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma 371 8511, Japan
    Lung Cancer 69:99-104. 2010
    ..This study was designed to confirm the efficacy and safety of amrubicin, a new anthracycline agent, in patients with previously treated non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC)...
  37. doi Extracellular acidification induces connective tissue growth factor production through proton-sensing receptor OGR1 in human airway smooth muscle cells
    Shinichi Matsuzaki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi 371 8511, Japan
    Biochem Biophys Res Commun 413:499-503. 2011
    ..In conclusion, extracellular acidification induces CTGF production through the OGR1/G(q/11) protein and inositol-1,4,5-trisphosphate-induced Ca(2+) mobilization in human ASMCs...
  38. doi Lung cancer producing granulocyte colony-stimulating factor and rapid spreading to peritoneal cavity
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma, Japan
    J Thorac Oncol 3:1054-5. 2008
    ..The final diagnosis obtained at autopsy demonstrated diffuse metastases spreading to peritoneal cavity resulting from G-CSF-producing lung cancer...
  39. doi Resolvin E1 dampens airway inflammation and hyperresponsiveness in a murine model of asthma
    Haruka Aoki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Biochem Biophys Res Commun 367:509-15. 2008
    ..These findings provide evidence that RvE1 is a pivotal counterregulatory signal in allergic inflammation and offer novel multi-pronged therapeutic approaches for human asthma...
  40. doi Comparison of L-type amino acid transporter 1 expression and L-[3-18F]-α-methyl tyrosine uptake in outcome of non-small cell lung cancer
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma 371 8511, Japan
    Nucl Med Biol 37:911-6. 2010
    ..The purpose of this study is to compare the prognostic significance of (18)F-FAMT uptake in the primary tumors with that of LAT1 expression in patients with NSCLC...
  41. ncbi Rac1 negatively regulates lipopolysaccharide-induced IL-23 p19 expression in human macrophages and dendritic cells and NF-kappaB p65 trans activation plays a novel role
    Mitsuyoshi Utsugi
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    J Immunol 177:4550-7. 2006
    ....
  42. ncbi Role of scavenger receptor class B type I and sphingosine 1-phosphate receptors in high density lipoprotein-induced inhibition of adhesion molecule expression in endothelial cells
    Takao Kimura
    Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi 371 8512, Japan
    J Biol Chem 281:37457-67. 2006
    ..In addition, the S1P component of HDL plays a role in the inhibition of TNFalpha-induced actions through S1P receptors, especially S1P(1)...
  43. doi L-type amino acid transporter 1 (LAT1) is frequently expressed in thymic carcinomas but is absent in thymomas
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma 371 8511, Japan
    J Surg Oncol 99:433-8. 2009
    ..We investigated the significance of LAT1 expression to evaluate malignant potential in thymic epithelial tumors...
  44. doi Promotion of cell spreading and migration by vascular endothelial-protein tyrosine phosphatase (VE-PTP) in cooperation with integrins
    Munemasa Mori
    Laboratory of Biosignal Sciences, Institute for Molecular and Cellular Regulation, Gunma University, Gunma, Japan
    J Cell Physiol 224:195-204. 2010
    ..These results suggest that VE-PTP, in cooperation with integrins, regulates the spreading and migration of endothelial cells during angiogenesis...
  45. ncbi Proton pump inhibitor improves breath marker in moderate asthma with gastroesophageal reflux disease
    Yasuo Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma, Japan
    Respiration 74:558-64. 2007
    ..Gastroesophageal reflux disease (GERD) influences the symptoms of asthma with acid and oxidative stress...
  46. ncbi [A case of large cell neuroendocrine carcinoma in a patient with sarcoidosis]
    Noriko Yanagitani
    Department of Medicine and Molecular Science, Gunma University
    Nihon Kokyuki Gakkai Zasshi 46:574-7. 2008
    ..In sarcoidosis patients, clinicians should be alert to the possibility of concomitant malignancy...
  47. ncbi [A case of cryptogenic organizing pneumonia with eosinophilic infiltration which was difficult to distinguish from nonspecific interstitial pneumonia]
    Noriko Yanagitani
    Department of Medicine and Molecular Science, Gunma University
    Nihon Kokyuki Gakkai Zasshi 47:286-90. 2009
    ..He had not taken any medication prior to coming to the hospital and he was negative for medicine-related pneumonia. The oral administration of prednisolone (0.5 mg/kg) improved his symptoms and also CT findings...
  48. ncbi Effects of fluticasone propionate on bone mineral density in patients with persistent bronchial asthma
    Tamotsu Ishizuka
    First Department of Internal Medicine, Gunma University School of Medicine, Maebashi
    Intern Med 41:798-804. 2002
    ..To evaluate osteoporosis in asthmatic patients...
  49. ncbi Clinicopathological features of patients with bronchial-associated lymphoid tissue lymphoma
    Hisao Imai
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi
    Intern Med 48:301-6. 2009
    ..Pulmonary MALT lymphoma, also known as bronchial-associated lymphoid tissue (BALT) lymphoma, is a rare disease and the clinicopathological features have yet to be clearly elucidated...
  50. ncbi Diagnostic usefulness of fluorine-18-alpha-methyltyrosine positron emission tomography in combination with 18F-fluorodeoxyglucose in sarcoidosis patients
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma 371 8511, Japan
    Chest 131:1019-27. 2007
    ..This study was conducted to investigate the usefulness of (18)F-FMT PET in combination with fluorine-18-fluorodeoxyglucose ((18)F-FDG) PET for the diagnosis of sarcoidosis in patients with suspected malignancy...
  51. pmc Proton-sensing ovarian cancer G protein-coupled receptor 1 on dendritic cells is required for airway responses in a murine asthma model
    Haruka Aoki
    Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    PLoS ONE 8:e79985. 2013
    ..We conclude that OGR1 on DCs is critical for migration to draining lymph nodes, which, in turn, stimulates Th2 phenotype change and subsequent induction of airway inflammation and AHR. ..
  52. doi Oxidative stress potentially enhances FcεRI-mediated leukotriene C4 release dependent on the late-phase increase of intracellular glutathione in mast cells
    Kaori Seki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi 371 8511, Japan
    Biochem Biophys Res Commun 439:357-62. 2013
    ..In some cases, oxidative stress may induce a late-phase increase in intracellular GSH, resulting in enhanced LTC4 release from mast cells...
  53. ncbi Inhibition of L-type amino acid transporter 1 has antitumor activity in non-small cell lung cancer
    Hisao Imai
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 Showa machi, Maebashi, Gunma 371 8511, Japan
    Anticancer Res 30:4819-28. 2010
    ..L-type amino acid transporter 1 (LAT1) is highly expressed in various human neoplasms. Antitumor activity of inhibiting LAT1 was analyzed in non-small cell lung cancer (NSCLC)...
  54. ncbi 8-Bromo-cAMP decreases the Ca2+ sensitivity of airway smooth muscle contraction through a mechanism distinct from inhibition of Rho-kinase
    Katsuaki Endou
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Am J Physiol Lung Cell Mol Physiol 287:L641-8. 2004
    ....
  55. ncbi Sphingosine 1-phosphate inhibits migration and RANTES production in human bronchial smooth muscle cells
    Tadayoshi Kawata
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15, Showa machi, Maebashi 371 8511, Japan
    Biochem Biophys Res Commun 331:640-7. 2005
    ..These results suggest that S1P attenuates cell migration by inhibiting a Rac1-dependent signaling pathway and decreases RANTES production by stimulating a Galpha(q)-dependent mechanism both possibly through the S1P(2) receptors...
  56. pmc Multiple lung metastases presenting as ground-glass opacities in a pulmonary adenocarcinoma: a case report
    Noriko Yanagitani
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine 3 39 15, Showa machi, Maebashi, Gunma 371 8511 Japan
    Cases J 2:6910. 2009
    ..Focal ground-glass opacity on computed tomography suggests several disorders including inflammatory disease, fibrosis, or a primary lung neoplastic lesion, metastatic lung tumor...
  57. ncbi A phase I dose escalation study of weekly docetaxel and carboplatin in elderly patients with nonsmall cell lung cancer
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma, Japan
    Am J Clin Oncol 30:51-6. 2007
    ....
  58. ncbi Pulmonary toxicity associated with vinorelbine-based chemotherapy in breast cancer
    Noriko Yanagitani
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Gan To Kagaku Ryoho 35:1619-21. 2008
    ..After discontinuing the above vinorelbine therapy, the patient's condition improved. We therefore diagnosed this as a case of vinorelbine-and trastuzumab-induced interstitial pneumonia...
  59. doi Forearm muscle metastasis as an initial clinical manifestation of lung cancer
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Shouwa machi, Maebashi, Gunma, Japan
    South Med J 102:79-81. 2009
    ..Skeletal muscle metastasis as a mode of presentation of primary lung cancer is an unusual phenomenon...
  60. doi Primary mediastinal synovial sarcoma: a report of 2 cases
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma, Japan
    J Comput Assist Tomogr 32:238-41. 2008
    ..They were treated with radiotherapy and chemotherapy. However, there was complete obstruction of esophagus resulting from progressive diseases. The radiographic findings and treatment were discussed...
  61. doi Laryngeal sarcoidosis detected by FDG positron emission tomography
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma, Japan
    Clin Nucl Med 33:878-9. 2008
    ..PET imaging demonstrated increased FDG uptake in the larynx. The histologic examination revealed laryngeal sarcoidosis. We report a case of laryngeal sarcoidosis and emphasize the role of FDG PET...
  62. ncbi Rapid growth of malignant pleural mesothelioma
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    J Thorac Oncol 2:966-7. 2007
  63. ncbi Sphingosine 1-phosphate receptors mediate stimulatory and inhibitory signalings for expression of adhesion molecules in endothelial cells
    Takao Kimura
    Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University, 3 39 15 Showa Machi, Maebashi 371 8512, Japan
    Cell Signal 18:841-50. 2006
    ..The stimulatory pathway involves nuclear factor kappa-B and inhibitory one does phosphatidylinositol 3-kinase and NOS...
  64. ncbi 4-Hydroxy-2-nonenal enhances fibronectin production by IMR-90 human lung fibroblasts partly via activation of epidermal growth factor receptor-linked extracellular signal-regulated kinase p44/42 pathway
    Hideo Tsukagoshi
    First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Gunma, Japan
    Toxicol Appl Pharmacol 184:127-35. 2002
    ....
  65. ncbi Glutathione redox regulates lipopolysaccharide-induced IL-12 production through p38 mitogen-activated protein kinase activation in human monocytes: role of glutathione redox in IFN-gamma priming of IL-12 production
    Mitsuyoshi Utsugi
    First Department of Internal Medicine, Faculty of Medicine, School of Medicine, Gunma University, Maebashi, Japan
    J Leukoc Biol 71:339-47. 2002
    ....
  66. ncbi Clinicopathologic significance of the mutations of the epidermal growth factor receptor gene in patients with non-small cell lung cancer
    Yoshio Tomizawa
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma, Japan
    Clin Cancer Res 11:6816-22. 2005
    ..The purpose of the present study is to gain further insights into the significance of EGFR mutation in non-small cell lung cancer (NSCLC)...
  67. ncbi DNA microarray genotyping of N-acetyltransferase 2 polymorphism using carbodiimide as the linker for assessment of isoniazid hepatotoxicity
    Yasuo Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Tuberculosis (Edinb) 86:374-81. 2006
    ..These findings suggest that our microarray may be clinically useful for predicting drug reactions to INH...
  68. ncbi A proton pump inhibitor, lansoprazole, ameliorates asthma symptoms in asthmatic patients with gastroesophageal reflux disease
    Yasuo Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Tohoku J Exp Med 209:181-9. 2006
    ..0) in asthmatic patients. In conclusion, treatment with a proton pump inhibitor, lansoprazole, appears to be useful in improvement of asthma symptoms in asthmatic patients with GERD...
  69. ncbi Serum amylase is a sensitive tumor marker for amylase-producing small cell lung cancer?
    Noriko Yanagitani
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma, 371 8511, Japan
    Int J Clin Oncol 12:231-3. 2007
    ..However, unfortunately, he died owing to deterioration of lung cancer. In this patient, the serum amylase level was found to be a highly sensitive marker of lung cancer...
  70. ncbi Resolvin E1 as a novel agent for the treatment of asthma
    Takeshi Hisada
    Gunma University Graduate School of Medicine, Department of Medicine and Molecular Science, Maebashi, 371 8511 Japan
    Expert Opin Ther Targets 13:513-22. 2009
    ..Although little is known about the actions of RvE1 in the resolution of inflammation due to asthma, recent studies in a mouse model have shown the possibilities of RvE1 in asthma...
  71. ncbi Epigenetic inactivation of the RUNX3 gene in lung cancer
    Koji Sato
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan
    Oncol Rep 15:129-35. 2006
    ..7%; p<0.001). These results indicated that silencing of the RUNX3 gene plays an important role in the pathogenesis of lung cancer, and aberrant methylation is an important mechanism of inactivation of the RUNX3 gene in lung AdC...
  72. ncbi Massive hemoptysis due to pulmonary tuberculosis
    Takeshi Hisada
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511
    Intern Med 44:156-7. 2005
  73. ncbi Interleukin-5 messenger RNA expression in peripheral blood mononuclear cells from patients with bronchial asthma and eosinophilia
    Takao Ishizuka
    First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan
    Allergy Asthma Proc 23:175-9. 2002
    ....
  74. ncbi Small cell carcinoma of the parotid gland
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma, Japan
    Otolaryngol Head Neck Surg 136:330-1. 2007
  75. ncbi Value of FDG positron emission tomography in monitoring the effects of therapy in progressive pulmonary sarcoidosis
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Clin Nucl Med 32:114-6. 2007
  76. ncbi Small cell carcinoma of the larynx in a long-term survivor of small-cell lung cancer
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma, Japan
    J Clin Oncol 24:2961-3. 2006
  77. doi Pulmonary traumatic pneumatocele and hematoma
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, 371 8511, Japan
    Jpn J Radiol 27:100-2. 2009
    ..Chest imaging revealed multiple pneumatoceles in bilateral lung fields. The patient was treated conservatively without surgical intervention. The pneumatocele had completely disappeared after 4 months...
  78. ncbi Coinfection of invasive pulmonary aspergillosis and pneumocystis jiroveci pneumonia in a non-HIV patient
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebachi, Gunma 371 8511, Japan
    Acta Med Okayama 61:235-8. 2007
    ..Our case demonstrated that short-term systemic steroid therapy in non-HIV patients with underlying chronic lung conditions and malignancies was a risk factor for IPA and PCP, and for a combination of these infections...
  79. ncbi Acute thrombocytopenia associated with preexisting ulcerative colitis successfully treated with colectomy
    Takeshi Hisada
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi
    Intern Med 45:87-91. 2006
    ..In this situation, colectomy might cure both UC and resistant thrombocytopenia. Steroid-refractory and life-threatening UC complicated by thrombocytopenia presumably caused by ITP is therefore a possible indication for colectomy...
  80. ncbi Effective combination chemotherapy of carboplatin and paclitaxel in the treatment of a recurrent small-cell lung cancer patient
    Kyoichi Kaira
    Dept of Medicine and Molecular Science, Gunma University Graduate School of Medicine
    Gan To Kagaku Ryoho 34:225-7. 2007
    ..Our result suggests that weekly chemotherapy with carboplatin and paclitaxel could be a well-tolerated and effective regimen for salvage chemotherapy of recurrent SCLC...
  81. ncbi [A case of elderly non-small cell lung cancer effectively treated by combined chemotherapy of gemcitabine and S-1]
    Kyoichi Kaira
    Dept of Medicine and Molecular Science, Gunma University Graduate School of Medicine
    Gan To Kagaku Ryoho 35:1587-9. 2008
    ..The treatment assessment was evaluated as partial response. No toxic events were observed due to this therapy, so she was treated as an outpatient. She was considered to have good quality of life...
  82. ncbi Acute respiratory failure associated with miliary tuberculosis successfully treated with sivelestat sodium hydrate
    Mitsuyoshi Utsugi
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511
    Intern Med 45:1069-70. 2006
  83. ncbi Usefulness of cholescintigraphy with lipid meal loading for diagnosis and determination of cholecystectomy in a patient with gallbladder dysfunction
    Shiko Kuribayashi
    First Department of Internal Medicine, Gunma University School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511
    Intern Med 43:393-6. 2004
    ..This case suggested the usefulness of cholescintigraphy with lipid meal loading for gallbladder dysfunction in determining whether or not to do cholecystectomy...