Yukio Horikawa

Summary

Affiliation: Gunma University
Country: Japan

Publications

  1. ncbi request reprint [Type 2 diabetes and genetic variations of calpain 10 gene]
    Yukio Horikawa
    Laboratory of Molecular Genetics, Department of Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University
    Nihon Rinsho 63:155-9. 2005
  2. doi request reprint Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan
    Yukio Horikawa
    Department of Diabetes and Endocrinology, Division of Molecule and Structure, Gifu University School of Medicine, Gifu, Japan
    J Clin Endocrinol Metab 93:3136-41. 2008
  3. ncbi request reprint Genetic variations in calpain-10 gene are not a major factor in the occurrence of type 2 diabetes in Japanese
    Yukio Horikawa
    Laboratory of Molecular Genetics, Department of Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371 8512, Japan
    J Clin Endocrinol Metab 88:244-7. 2003
  4. doi request reprint Hepatic overexpression of dominant negative Mlx improves metabolic profile in diabetes-prone C57BL/6J mice
    Katsumi Iizuka
    Laboratory of Medical Genomics, The Institute for Molecular and Cellular Regulation, Gunma University, Maebashi shi, 371 8512, Japan
    Biochem Biophys Res Commun 379:499-504. 2009
  5. doi request reprint Large-scale analysis of glucocorticoid target genes in rat hypothalamus
    Hirohito Sato
    Department of Psychiatry and Human Behavior, Gunma University Graduate School of Medicine, and Laboratory of Medical Genomics, Institute for Molecular and Cellular Regulation, Gunma, Japan
    J Neurochem 106:805-14. 2008
  6. ncbi request reprint [Calpain 10 as a susceptibility gene of type 2 diabetes]
    Yukio Horikawa
    Laboratory of Molecular Genetics, Department of Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University
    Nihon Rinsho 60:489-97. 2002
  7. doi request reprint Regulation of lipogenesis via BHLHB2/DEC1 and ChREBP feedback looping
    Katsumi Iizuka
    Laboratory of Medical Genomics, The Institute for Molecular and Cellular Regulation, Gunma University, Maebashi shi Gunma 371 8512, Japan
    Biochem Biophys Res Commun 374:95-100. 2008
  8. ncbi request reprint ChREBP: a glucose-activated transcription factor involved in the development of metabolic syndrome
    Katsumi Iizuka
    Laboratory of Medical Genomics, The Institute for Molecular and Cellular Regulation, Gunma University, Maebashi shi, Japan
    Endocr J 55:617-24. 2008
  9. ncbi request reprint Expression profile of mRNAs from rat hippocampus and its application to microarray
    Takeshi Tanaka
    Department of Psychiatry and Human Behavior, Gunma University, Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8512, Japan
    Brain Res Mol Brain Res 129:20-32. 2004
  10. ncbi request reprint [ChREBP]
    Katsumi Iizuka
    Laboratory of Medical Genomics, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University
    Nihon Rinsho 64:249-53. 2006

Collaborators

Detail Information

Publications30

  1. ncbi request reprint [Type 2 diabetes and genetic variations of calpain 10 gene]
    Yukio Horikawa
    Laboratory of Molecular Genetics, Department of Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University
    Nihon Rinsho 63:155-9. 2005
  2. doi request reprint Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan
    Yukio Horikawa
    Department of Diabetes and Endocrinology, Division of Molecule and Structure, Gifu University School of Medicine, Gifu, Japan
    J Clin Endocrinol Metab 93:3136-41. 2008
    ....
  3. ncbi request reprint Genetic variations in calpain-10 gene are not a major factor in the occurrence of type 2 diabetes in Japanese
    Yukio Horikawa
    Laboratory of Molecular Genetics, Department of Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371 8512, Japan
    J Clin Endocrinol Metab 88:244-7. 2003
    ....
  4. doi request reprint Hepatic overexpression of dominant negative Mlx improves metabolic profile in diabetes-prone C57BL/6J mice
    Katsumi Iizuka
    Laboratory of Medical Genomics, The Institute for Molecular and Cellular Regulation, Gunma University, Maebashi shi, 371 8512, Japan
    Biochem Biophys Res Commun 379:499-504. 2009
    ..In conclusion, overexpression of dnMlx improves glucose intolerance by inhibiting expression not only of lipogenic enzymes but also other important genes such as Glucose-6-phosphatase and Elovl6...
  5. doi request reprint Large-scale analysis of glucocorticoid target genes in rat hypothalamus
    Hirohito Sato
    Department of Psychiatry and Human Behavior, Gunma University Graduate School of Medicine, and Laboratory of Medical Genomics, Institute for Molecular and Cellular Regulation, Gunma, Japan
    J Neurochem 106:805-14. 2008
    ..Considering that a number of these GC-responsive genes are candidate neuronal regulators, this gene list should be useful in clarifying the relationship between GC insufficiency and the pathogenesis of MDD...
  6. ncbi request reprint [Calpain 10 as a susceptibility gene of type 2 diabetes]
    Yukio Horikawa
    Laboratory of Molecular Genetics, Department of Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University
    Nihon Rinsho 60:489-97. 2002
  7. doi request reprint Regulation of lipogenesis via BHLHB2/DEC1 and ChREBP feedback looping
    Katsumi Iizuka
    Laboratory of Medical Genomics, The Institute for Molecular and Cellular Regulation, Gunma University, Maebashi shi Gunma 371 8512, Japan
    Biochem Biophys Res Commun 374:95-100. 2008
    ..ChIP assay demonstrated that BHLHB2 bound to ChoRE in the Fasn, Lpk, and Bhlhb2 promoter regions in vivo. In conclusion, BHLHB2 and ChREBP constitute a novel feedback loop involved in the regulation of lipogenesis...
  8. ncbi request reprint ChREBP: a glucose-activated transcription factor involved in the development of metabolic syndrome
    Katsumi Iizuka
    Laboratory of Medical Genomics, The Institute for Molecular and Cellular Regulation, Gunma University, Maebashi shi, Japan
    Endocr J 55:617-24. 2008
    ..Thus, further clarification of the physiological role of ChREBP may be useful in developing treatments for the metabolic syndrome...
  9. ncbi request reprint Expression profile of mRNAs from rat hippocampus and its application to microarray
    Takeshi Tanaka
    Department of Psychiatry and Human Behavior, Gunma University, Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8512, Japan
    Brain Res Mol Brain Res 129:20-32. 2004
    ..These ESTs and our own microarray thus provide an improved genomic source for molecular studies of animal models of stress-related disorders...
  10. ncbi request reprint [ChREBP]
    Katsumi Iizuka
    Laboratory of Medical Genomics, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University
    Nihon Rinsho 64:249-53. 2006
  11. ncbi request reprint Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians
    Søren K Rasmussen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark
    Diabetes 51:3561-7. 2002
    ....
  12. ncbi request reprint Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects
    Norihide Yokoi
    Division of Cellular and Molecular Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Diabetes 55:2379-86. 2006
    ..This is the largest association study so far conducted on these genes in Japanese and provides valuable information for comparison with other ethnic groups...
  13. ncbi request reprint Calpain-10 (NIDDM1) as a Susceptibility Gene for Common Type 2 Diabetes
    Yukio Horikawa
    Department of Diabetes and Endocrinology, Gifu University School of Medicine, Yanagido, Gifu, Japan
    Endocr J 53:567-76. 2006
  14. ncbi request reprint Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects
    Kazuaki Miyake
    Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Hum Genet 53:174-80. 2008
    ..However, neither rs11196218 nor rs290487 showed a significant association. These results indicate that TCF7L2 is an important susceptibility gene for type 2 diabetes in the Japanese population...
  15. pmc Geographic and haplotype structure of candidate type 2 diabetes susceptibility variants at the calpain-10 locus
    Stephanie M Fullerton
    Department of Human Genetics, The University of Chicago, Chicago, IL 60637, USA
    Am J Hum Genet 70:1096-106. 2002
    ..These results suggest a history of positive natural selection at the locus, resulting in significant geographic differences in polymorphism frequencies. The relationship of these differences to disease risk is discussed...
  16. ncbi request reprint Lack of association of LRP5 and LRP6 polymorphisms with type 2 diabetes mellitus in the Japanese population
    Masako Zenibayashi
    Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan
    Endocr J 55:699-707. 2008
    ..The aim of the present study was to examine whether common variants of LRP5 and LRP6 are associated with Type 2 DM or dyslipidemia in Japanese individuals...
  17. ncbi request reprint Variation in the calpain-10 gene affects blood glucose levels in the British population
    Stephen Lynn
    School of Clinical Medical Sciences, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Diabetes 51:247-50. 2002
    ..002). We conclude that genetic variation in the CAPN10 gene influences blood glucose levels in nondiabetic British subjects and that this is due, at least in part, to the effects of calpain-10 on the early insulin secretory response...
  18. ncbi request reprint Genetic variation in the hypoxia-inducible factor-1alpha gene is associated with type 2 diabetes in Japanese
    Norihiro Yamada
    Department of Ophthalmology, Gunma University Graduate School of Medicine, Japan
    J Clin Endocrinol Metab 90:5841-7. 2005
    ..Vascular endothelial growth factor mRNA levels increase as a result of increased transcriptional activation, mediated predominantly by hypoxia-inducible factor-1 alpha (HIF-1alpha) in response to hypoxia...
  19. ncbi request reprint Relationship of calpain-10 genotype to phenotypic features of polycystic ovary syndrome
    David A Ehrmann
    Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    J Clin Endocrinol Metab 87:1669-73. 2002
    ..In addition to its association with insulin levels in African-Americans, the 112/121-haplotype combination was associated with an approximate 2-fold increase in risk of PCOS in both African-Americans and whites...
  20. ncbi request reprint Genetic variants in the calpain-10 gene and the development of type 2 diabetes in the Japanese population
    Naoko Iwasaki
    Diabetes Center, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo, 162 8666, Japan
    J Hum Genet 50:92-8. 2005
    ..82 and 0.80, respectively; P=0.04 and 0.02). Thus, variation in the calpain-10 gene may affect risk of type 2 diabetes in Japanese, especially in older individuals...
  21. ncbi request reprint A 48-hour exposure of pancreatic islets to calpain inhibitors impairs mitochondrial fuel metabolism and the exocytosis of insulin
    Yun Ping Zhou
    Departments of Medicine, Neurobiology, Pharmacology and Physiology, Biochemistry and Molecular Biology, Human Genetics, and the Howard Hughes Medical Institute, University of Chicago, Chicago, IL, USA
    Metabolism 52:528-34. 2003
    ....
  22. ncbi request reprint Genetic variations in the WFS1 gene in Japanese with type 2 diabetes and bipolar disorder
    Takanori Kawamoto
    Department of Neuropsychiatry, Gunma University School of Medicine, Gunma, Japan
    Mol Genet Metab 82:238-45. 2004
    ..These genetic variations and linkage disequilibrium patterns in WFS1 in Japanese should be useful in further investigation of genetic diversities of WFS1 and various related disorders...
  23. ncbi request reprint RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets
    James D Johnson
    Department of Internal Medicine, Washington University, St Louis, Missouri 63110, USA
    J Biol Chem 279:24794-802. 2004
    ..Thus RyR2 activity seems to play an essential role in beta-cell survival in vitro by suppressing a death pathway mediated by calpain-10, a type 2 diabetes susceptibility gene with previously unknown function...
  24. ncbi request reprint [Transcription factors and diabetes mellitus]
    Yukio Horikawa
    Nihon Naika Gakkai Zasshi 92:890-6. 2003
  25. pmc Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility
    Michael N Weedon
    Am J Hum Genet 73:1208-12. 2003
  26. ncbi request reprint Genetic variants of hepatocyte nuclear factor-1beta in Chinese young-onset diabetic patients with nephropathy
    W Y So
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, SAR, Hong Kong, China
    J Diabetes Complications 17:369-73. 2003
    ..Other potential candidate genes should be looked for to account for the high prevalence of young-onset diabetes and nephropathy in this population...
  27. ncbi request reprint Calpain system regulates muscle mass and glucose transporter GLUT4 turnover
    Kenichi Otani
    Department of Medicine, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Biol Chem 279:20915-20. 2004
    ..These findings provide evidence for a physiological role for calpains in the regulation of muscle glucose metabolism and muscle mass...
  28. doi request reprint The ratio of leptin to adiponectin can be used as an index of insulin resistance
    Naohisa Oda
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Metabolism 57:268-73. 2008
    ..The correlation of L/A and GIR by the euglycemic hyperinsulinemic clamp test suggests that L/A is a useful indicator for the choice of drug to treat diabetes mellitus...
  29. ncbi request reprint [MODY]
    Akihiko Sasaki
    Department of Diabetes and Endocrinology, Division of Molecule and Structure Research Field of Medical Sciences, Graduate School of Medicine, Gifu University
    Nihon Rinsho . 2006
  30. ncbi request reprint A functional variant in the human betacellulin gene promoter is associated with type 2 diabetes
    Yoshio Nakano
    The First Department of Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8509, Japan
    Diabetes 54:3560-6. 2005
    ..These results suggest that the -226A/G polymorphism of the BTC gene may contribute to the development of diabetes...