Koshi Hashimoto

Summary

Affiliation: Gunma University
Country: Japan

Publications

  1. ncbi Tyrosine phosphorylation of Munc18c regulates platelet-derived growth factor-stimulated glucose transporter 4 translocation in 3T3L1 adipocytes
    Mitsuhiko Umahara
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Endocrinology 149:40-9. 2008
  2. doi A liver X receptor (LXR)-beta alternative splicing variant (LXRBSV) is preferentially expressed in the pituitary
    Koshi Hashimoto
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, 3 39 15 Showa machi Maebashi, Gunma 371 8511, Japan
    Biochem Biophys Res Commun 394:548-52. 2010
  3. ncbi Crosstalk of thyroid hormone receptor and liver X receptor in lipid metabolism and beyond [Review]
    Koshi Hashimoto
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma 371 8511, Japan
    Endocr J 58:921-30. 2011
  4. ncbi Mouse sterol response element binding protein-1c gene expression is negatively regulated by thyroid hormone
    Koshi Hashimoto
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, 3 39 15 Showa machi Maebashi, Gunma 371 8511, Japan
    Endocrinology 147:4292-302. 2006
  5. ncbi Liver X receptor-alpha gene expression is positively regulated by thyroid hormone
    Koshi Hashimoto
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, 3 39 22 Showa machi Maebashi, Gunma, Japan 371 8511
    Endocrinology 148:4667-75. 2007
  6. pmc Carbohydrate response element binding protein gene expression is positively regulated by thyroid hormone
    Koshi Hashimoto
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, 3 39 15 Showa machi Maebashi, Gunma, Japan
    Endocrinology 150:3417-24. 2009
  7. doi A liver X receptor (LXR)-beta alternative splicing variant (LXRBSV) acts as an RNA co-activator of LXR-beta
    Koshi Hashimoto
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, Maebashi, Gunma 371 8511, Japan
    Biochem Biophys Res Commun 390:1260-5. 2009
  8. doi Liver X receptor-α/β expression ratio is increased in ACTH-secreting pituitary adenomas
    Koshi Hashimoto
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, 3 39 15 Showa Machi, Maebashi 371 8511, Gunma, Japan
    Neurosci Lett 494:34-7. 2011
  9. doi THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation
    Akiko Katano-Toki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Mol Endocrinol 27:769-80. 2013
  10. pmc NR4A1 (Nur77) mediates thyrotropin-releasing hormone-induced stimulation of transcription of the thyrotropin β gene: analysis of TRH knockout mice
    Yasuyo Nakajima
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    PLoS ONE 7:e40437. 2012

Collaborators

Detail Information

Publications60

  1. ncbi Tyrosine phosphorylation of Munc18c regulates platelet-derived growth factor-stimulated glucose transporter 4 translocation in 3T3L1 adipocytes
    Mitsuhiko Umahara
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Endocrinology 149:40-9. 2008
    ..Together, these data demonstrate that one mechanism accounting for the PDGF induction of Glut4 translocation is the suppression of the Munc18c negative regulation of Syntaxin 4 function...
  2. doi A liver X receptor (LXR)-beta alternative splicing variant (LXRBSV) is preferentially expressed in the pituitary
    Koshi Hashimoto
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, 3 39 15 Showa machi Maebashi, Gunma 371 8511, Japan
    Biochem Biophys Res Commun 394:548-52. 2010
    ..These data provide clues to elucidating the physiological relevance of LXRBSV...
  3. ncbi Crosstalk of thyroid hormone receptor and liver X receptor in lipid metabolism and beyond [Review]
    Koshi Hashimoto
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma 371 8511, Japan
    Endocr J 58:921-30. 2011
    ..In this review, recent advances in elucidating the molecular mechanisms of the crosstalk between these two nuclear receptors are discussed, with the aim of finding a perspective on unknown roles of TRs and LXRs...
  4. ncbi Mouse sterol response element binding protein-1c gene expression is negatively regulated by thyroid hormone
    Koshi Hashimoto
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, 3 39 15 Showa machi Maebashi, Gunma 371 8511, Japan
    Endocrinology 147:4292-302. 2006
    ..Thus, we demonstrated that mouse SREBP-1c mRNA is down-regulated by T3 in vivo and that T3 negatively regulates mouse SREBP-1c gene transcription via a novel negative thyroid hormone response element: Site2...
  5. ncbi Liver X receptor-alpha gene expression is positively regulated by thyroid hormone
    Koshi Hashimoto
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, 3 39 22 Showa machi Maebashi, Gunma, Japan 371 8511
    Endocrinology 148:4667-75. 2007
    ..This novel insight that thyroid hormone regulates LXR-alpha mRNA levels and promoter activity should shed light on a cross talk between LXR-alpha and TR-beta1 as a new therapeutic target against dyslipidemia and atherosclerosis...
  6. pmc Carbohydrate response element binding protein gene expression is positively regulated by thyroid hormone
    Koshi Hashimoto
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, 3 39 15 Showa machi Maebashi, Gunma, Japan
    Endocrinology 150:3417-24. 2009
    ..This novel observation indicates that TH fine-tunes hepatic lipogenesis via regulating SREBP-1c and ChREBP gene expression reciprocally...
  7. doi A liver X receptor (LXR)-beta alternative splicing variant (LXRBSV) acts as an RNA co-activator of LXR-beta
    Koshi Hashimoto
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, Maebashi, Gunma 371 8511, Japan
    Biochem Biophys Res Commun 390:1260-5. 2009
    ..In the current study, we have demonstrated for the first time that an alternative splicing variant of a nuclear receptor acts as an RNA co-activator...
  8. doi Liver X receptor-α/β expression ratio is increased in ACTH-secreting pituitary adenomas
    Koshi Hashimoto
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, 3 39 15 Showa Machi, Maebashi 371 8511, Gunma, Japan
    Neurosci Lett 494:34-7. 2011
    ..Thus, we concluded that LXR-α/β gene expression ratio is a critical factor to activate POMC gene expression in ACTH-secreting pituitary adenomas...
  9. doi THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation
    Akiko Katano-Toki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Mol Endocrinol 27:769-80. 2013
    ..These findings collectively suggest that Thrap3 could play indispensable roles in terminal differentiation of adipocytes by enhancing PPARγ-mediated gene activation cooperatively with Helz2...
  10. pmc NR4A1 (Nur77) mediates thyrotropin-releasing hormone-induced stimulation of transcription of the thyrotropin β gene: analysis of TRH knockout mice
    Yasuyo Nakajima
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    PLoS ONE 7:e40437. 2012
    ....
  11. doi Liver X receptor-alpha regulates proopiomelanocortin (POMC) gene transcription in the pituitary
    Shunichi Matsumoto
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, 3 39 15 Showa machi Maebashi, Gunma 371 8511, Japan
    Mol Endocrinol 23:47-60. 2009
    ..Our findings provide the first evidence that LXR-alpha positively regulates the POMC gene promoter at the transcriptional level and suggest LXR-alpha to be a coordinator for cross talk between lipid metabolism and neuroendocrinology...
  12. doi Troglitazone, a ligand of peroxisome proliferator-activated receptor-{gamma}, stabilizes NUCB2 (Nesfatin) mRNA by activating the ERK1/2 pathway: isolation and characterization of the human NUCB2 gene
    Masanobu Yamada
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Endocrinology 151:2494-503. 2010
    ....
  13. pmc Tat-binding protein-1 (TBP-1), an ATPase of 19S regulatory particles of the 26S proteasome, enhances androgen receptor function in cooperation with TBP-1-interacting protein/Hop2
    Tetsurou Satoh
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Endocrinology 150:3283-90. 2009
    ..These findings suggest that a component of 19S regulatory particles directly binds AR and might participate in AR-mediated transcriptional activation in cooperation with TBPIP...
  14. doi Thyroid hormone receptor and liver X receptor competitively up-regulate human selective Alzheimer's disease indicator-1 gene expression at the transcriptional levels
    Emi Ishida
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Biochem Biophys Res Commun 432:513-8. 2013
    ..Taken together, we concluded that TR-β and LXR-α competitively up-regulate the human Seladin-1 promoter, sharing the same response element, site A...
  15. pmc Secreted nucleobindin-2 inhibits 3T3-L1 adipocyte differentiation
    Yuko Tagaya
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Protein Pept Lett 19:997-1004. 2012
    ..Taken together, these data indicate that secreted Nucleobindin-2 is a suppressor of adipocyte differentiation through inhibition of cAMP production and insulin signal...
  16. ncbi KCNJ5 mutations in aldosterone- and cortisol-co-secreting adrenal adenomas
    Masanobu Yamada
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Endocr J 59:735-41. 2012
    ..These findings suggested that at least some aldosterone- and cortisol-co-secreting adrenal tumors have mutations of the KCNJ5 gene, suggesting the origin to be APA, and pure APAs may show a high incidence of KCNJ5 mutations...
  17. ncbi CDK5-dependent phosphorylation of the Rho family GTPase TC10(alpha) regulates insulin-stimulated GLUT4 translocation
    Shuichi Okada
    Department of Medicine, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma 371 0034, Japan
    J Biol Chem 283:35455-63. 2008
    ..Because cortical actin reorganization is required for insulin-stimulated GLUT4 translocation, these data are consistent with a CDK5-dependent TC10alpha cycling between lipid raft and non-lipid raft compartments...
  18. doi Transcriptional activation of the mixed lineage leukemia-p27Kip1 pathway by a somatostatin analogue
    Kazuhiko Horiguchi
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Clin Cancer Res 15:2620-9. 2009
    ..We hypothesized that the same pathway might be involved in sporadic pituitary adenomas...
  19. ncbi Dilated cardiomyopathy as a presenting feature of Cushing's syndrome
    Nobuyuki Shibusawa
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Japan
    Intern Med 52:1067-71. 2013
    ..Administering appropriate treatment in a timely manner can reverse this cardiomyopathy along with the other symptoms of Cushing's syndrome...
  20. doi Resistance to thyroid hormone due to a novel thyroid hormone receptor mutant in a patient with hypothyroidism secondary to lingual thyroid and functional characterization of the mutant receptor
    Yasuyo Nakajima
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Thyroid 20:917-26. 2010
    ..To aid in assessment of the therapy, we characterized the mutant R316C thyroid hormone receptor (TR) and compared it with a common mutant, R316H, using in vitro studies...
  21. doi Haploinsufficient and predominant expression of multiple endocrine neoplasia type 1 (MEN1)-related genes, MLL, p27Kip1 and p18Ink4C in endocrine organs
    Ryo Taguchi
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    Biochem Biophys Res Commun 415:378-83. 2011
    ..These findings may provide basic information for understanding the mechanisms of tissue selectivity of the tumorigenesis in patients with MEN1...
  22. ncbi Cross-talk between thyroid hormone receptor and liver X receptor regulatory pathways is revealed in a thyroid hormone resistance mouse model
    Koshi Hashimoto
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, Maebashi, Gunma 371 8511, Japan
    J Biol Chem 281:295-302. 2006
    ..Electromobility shift analysis revealed that LXR/RXR heterodimers bound to the DR+4 element in the presence of MUT but not WT TR-beta. A mechanism for cross-talk, and potential antagonism, between TR-beta and LXR-alpha is proposed...
  23. ncbi A novel splice variant of the nuclear coactivator p120 functions strongly for androgen receptor: characteristic expression in prostate disease
    Takeshi Hosoya
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Endocr J 55:657-65. 2008
    ..These findings suggested that while p120alpha was essential for ligand-dependent stimulation of TRs and PPARgamma, p120beta acted as a coactivating protein predominantly for AR...
  24. pmc Nesfatin-1 induces the phosphorylation levels of cAMP response element-binding protein for intracellular signaling in a neural cell line
    Emi Ishida
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    PLoS ONE 7:e50918. 2012
    ..Our study highlights that Nesfatin-1, via its receptor, induces the phosphorylation of CREB, thus activating the intracellular signaling cascade in neurons...
  25. doi Human stearoyl-CoA desaturase 1 (SCD-1) gene expression is negatively regulated by thyroid hormone without direct binding of thyroid hormone receptor to the gene promoter
    Koshi Hashimoto
    3 39 22 Showa machi, Maebashi, Gunma, Japan 371 8511
    Endocrinology 154:537-49. 2013
    ..In conclusion, TH negatively regulates human SCD-1 gene expression in without direct binding of the TH receptor to the SCD-1 gene promoter...
  26. pmc Syntaxin4 interacting protein (Synip) binds phosphatidylinositol (3,4,5) triphosphate
    Tsugumichi Saito
    Department of Medicine and Molecular Science, Gunma University School of Medicine, Maebashi, Gunma, Japan
    PLoS ONE 7:e42782. 2012
    ..These data suggest that in the presence of insulin, the dissociated Synip remains anchored to the plasma membrane by binding to PIP3...
  27. ncbi Prolactin secretion in mice with thyrotropin-releasing hormone deficiency
    Masanobu Yamada
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Endocrinology 147:2591-6. 2006
    ....
  28. doi Expression and mutations of KCNJ5 mRNA in Japanese patients with aldosterone-producing adenomas
    Ryo Taguchi
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    J Clin Endocrinol Metab 97:1311-9. 2012
    ..Mutations of the KCNJ5 gene have recently been identified in patients with aldosterone-producing adenomas (APA)...
  29. ncbi Cardiovascular complications of patients with aldosteronism associated with autonomous cortisol secretion
    Yasuyo Nakajima
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma 371 8511, Japan
    J Clin Endocrinol Metab 96:2512-8. 2011
    ..Primary aldosteronism (PA) is sometimes associated with the autonomous secretion of cortisol...
  30. pmc Aberrant histone modifications at the thyrotropin-releasing hormone gene in resistance to thyroid hormone: analysis of F455S mutant thyroid hormone receptor
    Ryohei Umezawa
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Endocrinology 150:3425-32. 2009
    ....
  31. ncbi Synip phosphorylation is required for insulin-stimulated Glut4 translocation and glucose uptake in podocyte [Rapid Communication]
    Eijiro Yamada
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi 371 8511, Japan
    Endocr J 61:523-7. 2014
    ....
  32. ncbi Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma
    Takuya Tomaru
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi 371 8511, Japan
    Endocrinology 147:377-88. 2006
    ..Together, PDIP1 might function as a transcriptional cofactor for a broad range of nuclear receptors, possibly in collaboration with specific activation function-2 interacting coactivators...
  33. doi Roles of proteasomal 19S regulatory particles in promoter loading of thyroid hormone receptor
    Tetsurou Satoh
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi 371 8511, Japan
    Biochem Biophys Res Commun 386:697-702. 2009
    ..Collectively, both ATPase and non-ATPase components of 19SRP play critical roles in TR-mediated transactivation by coordinating the proper loading of liganded TR to TRE...
  34. ncbi Isolation of a novel leptin receptor gene promoter preferentially functioning in neuronal cells
    Tetsurou Satoh
    Department of Medicine and Molecular Science, Gunma University, Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Japan
    Biochem Biophys Res Commun 389:673-7. 2009
    ..Deletion analyses identifying two enhancer elements were located in this promoter. The identification of a novel ob-r gene promoter might provide a useful tool to study neuron specific expression and hormonal regulation of the ob-r gene...
  35. ncbi A novel TRH-PFTAIRE protein kinase 1 pathway in the cerebellum: subtractive hybridization analysis of TRH-deficient mice
    Tetsu Hashida
    First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan
    Endocrinology 143:2808-11. 2002
    ..These findings demonstrated, for the first time, a novel pathway between a neuropeptide and a cell cycle related peptide in the brain, and PFTK1 may be a key regulator for TRH action in t he cerebellum through t he NO-cGMP pathway...
  36. ncbi Somatostatin receptor subtypes mRNA in TSH-secreting pituitary adenomas: a case showing a dramatic reduction in tumor size during short octreotide treatment
    Kazuhiko Horiguchi
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Endocr J 54:371-8. 2007
    ....
  37. pmc Crosstalk between thyroid hormone receptor and liver X receptor in the regulation of selective Alzheimer's disease indicator-1 gene expression
    Emi Ishida
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    PLoS ONE 8:e54901. 2013
    ..Taking these findings together, we concluded that TH up-regulates Seladin-1 gene expression at the transcriptional level and LXR-α maintains the gene expression...
  38. doi Fasting concentrations of nesfatin-1 are negatively correlated with body mass index in non-obese males
    Takafumi Tsuchiya
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma, Japan Shibayagi Co Ltd, Shibukawa, Gunma, Japan
    Clin Endocrinol (Oxf) 73:484-90. 2010
    ..We recently identified a novel anorexigenic protein, nesfatin-1, which is processed from nesfatin/nucleobindin-2 (NUCB2). However, the clinical importance of this protein has not been determined...
  39. ncbi Synip phosphorylation is required for insulin-stimulated Glut4 translocation
    Shuichi Okada
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15, Showa machi, Maebashi, Gunma 371 8511, Japan
    Biochem Biophys Res Commun 356:102-6. 2007
    ..These data are consistent with Synip serine 99 phosphorylation required for insulin-stimulated Glut4 translocation...
  40. ncbi Thyrotropin-releasing hormone (TRH) specific interaction between amino terminus of P-Lim and CREB binding protein (CBP)
    Koshi Hashimoto
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa machi Maebashi, Gunma 371 8511, Japan
    Mol Cell Endocrinol 229:11-20. 2005
    ..These studies have elucidated the molecular mechanism by which TRH stimulates alpha-GSU gene expression...
  41. ncbi Attenuated expression of menin and p27 (Kip1) in an aggressive case of multiple endocrine neoplasia type 1 (MEN1) associated with an atypical prolactinoma and a malignant pancreatic endocrine tumor
    Emi Ishida
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Endocr J 58:287-96. 2011
    ..The tumor in this case may be a subtype of MEN1 showing more aggressive and malignant features probably induced by low levels of menin and p27...
  42. doi Subclinical hypothyroidism and indices for metabolic syndrome in Japanese women: one-year follow-up study
    Yasuyo Nakajima
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    J Clin Endocrinol Metab 98:3280-7. 2013
    ..Objective: Our objective was to investigate the relationship between SCH and indices of metabolic syndrome and follow up subjects for 1 year...
  43. ncbi Loss of consciousness and hypokalemia in an elderly man with a mutation of the thiazide-sensitive Na-Cl cotransporter gene
    Tetsu Hashida
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Endocr J 53:859-63. 2006
    ..Therefore, the mutation found in this patient may be responsible for Gitelman's syndrome...
  44. ncbi Transcriptional regulation of the human PRL-releasing peptide (PrRP) receptor gene by a dopamine 2 Receptor agonist: cloning and characterization of the human PrRP receptor gene and its promoter region
    Atsushi Ozawa
    First Department of Internal Medicine, Gunma University School of Medicine, Maebashi 371 8511, Japan
    Mol Endocrinol 16:785-98. 2002
    ....
  45. ncbi Primary bilateral adrenal diffuse large B-cell lymphoma demonstrating adrenal failure
    Kazuhiko Horiguchi
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, Maebashi
    Intern Med 49:2241-6. 2010
    ..We concluded that PAL should be considered as a possible cause of bilateral adrenal incidentalomas with progressive adrenal insufficiency...
  46. ncbi Discovery of nesfatin-1 and overview of biological actions and new developments
    Masatomo Mori
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi 371 8511, Japan
    Curr Pharm Des 19:6921-8. 2013
    ..We discuss what is currently known about nesfatin-1, including new developments in our understanding of its distribution, regulation, and biological function. ..
  47. ncbi A patient with classic severe primary hyperparathyroidism in whom both Tc-99m MIBI scintigraphy and FDG-PET failed to detect the parathyroid tumor
    Kaori Seki
    Department of Molecular and Clinical Medicine, Gunma University Graduate School of Medicine, Maebashi
    Intern Med 43:816-23. 2004
    ....
  48. doi Primary mediastinal synovial sarcoma: a report of 2 cases
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma, Japan
    J Comput Assist Tomogr 32:238-41. 2008
    ..They were treated with radiotherapy and chemotherapy. However, there was complete obstruction of esophagus resulting from progressive diseases. The radiographic findings and treatment were discussed...
  49. doi Thyrotropin-releasing hormone (TRH) in the cerebellum
    Nobuyuki Shibusawa
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Cerebellum 7:84-95. 2008
    ..TRH and TRH analogs are promising clinical therapeutic agents for inducing arousal effects, amelioration of mental depression, and improvement of cerebellar ataxia...
  50. ncbi [Expression and function of the thyrotropin-releasing hormone (TRH)]
    Koshi Hashimoto
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
    Nihon Rinsho 63:66-71. 2005
  51. ncbi [Congenital TSH * PRL combined deficiency (TRH receptor gene mutation)]
    Koshi Hashimoto
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
    Nihon Rinsho . 2006
  52. ncbi [Hypothalamic hypogonadism associated with GRH and CRH deficiencies]
    Ryohei Umezawa
    Department of Molecular and Clinical Medicine, Gunma University Graduate School of Medicine, Maebashi
    Nihon Naika Gakkai Zasshi 92:2420-2. 2003
  53. ncbi Enteropathy-type T-cell lymphoma that was pathologically diagnosed as celiac disease
    Hidetoshi Yasuoka
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, Maebashi
    Intern Med 46:1219-24. 2007
    ..In light of the histological findings, we concluded that this was a case of ETL associated with celiac disease, which is extremely rare in Japan...
  54. ncbi [Guidelines for the diagnosis and management of thyroid disease and their utility]
    Koshi Hashimoto
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
    Nihon Rinsho 70:1857-64. 2012
    ..The latter in English version has been published in Thyroid(http : //www.ncbi.nlm.nih.gov/pubmed/22494618). The utility of these guidelines is discussed...
  55. ncbi Expression of thyroid hormone receptor isoforms down-regulated by thyroid hormone in human medulloblastoma cells
    Tsuyoshi Monden
    Department of Endocrinology and Metabolism, Dokkyo University School of Medicine, Tochigi, Japan
    Endocr J 53:181-7. 2006
    ..Our data provide novel evidence for the expression of TRs down-regulated by T3 in HTB-185 cells, suggesting that TR expression is post-transcriptionally regulated by T3 at the level of RNA stability...
  56. ncbi Unliganded RXR acts as an inhibitory factor on troglitazone-induced activation
    Tsuyoshi Monden
    Department of Endocrinology and Metabolism, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Shimotsuga gun, Tochigi 321 0293, Japan
    Life Sci 76:731-41. 2004
    ....
  57. pmc Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo
    Nobuyuki Shibusawa
    Department of Medicine, University of Chicago, 5841 S Maryland Avenue, MC1027, Chicago, Illinois 60637, USA
    J Clin Invest 112:588-97. 2003
    ..Inner ear development, although not completely normal, can occur in the absence of TR DNA-binding, suggesting that an alternative and perhaps novel thyroid hormone-signaling pathway may mediate these effects...
  58. ncbi Herbal medicine, Hachimi-jio-gan, and its component cinnamomi cortex activate the peroxisome proliferator-activated receptor alpha in renal cells
    Tsuyoshi Monden
    Department of Endocrinology and Metabolism, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Endocr J 55:529-33. 2008
    ..Taken together, these findings indicate that Hachimi-jio-gan and cinnamomi cortex may have a pharmacological effect through the target site for PPARalpha...
  59. ncbi Dominant role of thyrotropin-releasing hormone in the hypothalamic-pituitary-thyroid axis
    Amisra A Nikrodhanond
    Department of Medicine and the Committee on Molecular Metabolism and Nutrition, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 281:5000-7. 2006
    ..Thus, TRH is absolutely required for both TSH and TH synthesis but is not necessary for thyrotroph cell development...
  60. ncbi Thyroid hormone resistance in the heart: role of the thyroid hormone receptor beta isoform
    Tania M Ortiga-Carvalho
    Department of Medicine, Pritzker School of the Medicine, The University of Chicago, Illinois 60637, USA
    Endocrinology 145:1625-33. 2004
    ..In contrast, HR in KS-mut animals did not change after either treatment. Except for cardiac hypertrophy, the presence of a germline TR-beta mutation had surprisingly little effect on cardiac function...