Masayoshi Yamaguchi

Summary

Affiliation: Graduate School
Country: Japan

Publications

  1. ncbi request reprint Role of endogenous regucalcin in bone metabolism: bone loss is induced in regucalcin transgenic rats
    Masayoshi Yamaguchi
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Japan
    Int J Mol Med 10:377-83. 2002
  2. ncbi request reprint Role of albumin in osteoblastic cells: enhancement of cell proliferation and suppression of alkaline phosphatase activity
    Koichi Ishida
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Int J Mol Med 14:1077-81. 2004
  3. ncbi request reprint beta-cryptoxanthin stimulates cell differentiation and mineralization in osteoblastic MC3T3-E1 cells
    Satoshi Uchiyama
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    J Cell Biochem 95:1224-34. 2005
  4. ncbi request reprint Effects of flavonoid on calcium content in femoral tissue culture and parathyroid hormone-stimulated osteoclastogenesis in bone marrow culture in vitro
    Masayoshi Yamaguchi
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Shizuoka, Japan
    Mol Cell Biochem 303:83-8. 2007
  5. doi request reprint Vitamin K2 stimulates osteoblastogenesis and suppresses osteoclastogenesis by suppressing NF-κB activation
    Masayoshi Yamaguchi
    Emory University School of Medicine, 101 Woodruff Circle, 1329 WMRB, Atlanta, GA 30322, USA
    Int J Mol Med 27:3-14. 2011
  6. ncbi request reprint Curcumin analogue UBS109 prevents bone loss in breast cancer bone metastasis mouse model: involvement in osteoblastogenesis and osteoclastogenesis
    Masayoshi Yamaguchi
    Department of Hematology and Medical Oncology, Emory University School of Medicine, 1365 C Clifton Road NE, Atlanta, GA, 30322, USA
    Cell Tissue Res 357:245-52. 2014
  7. ncbi request reprint Regucalcin as a potential biomarker for metabolic and neuronal diseases
    Masayoshi Yamaguchi
    Department of Hematology and Medical Oncology, Emory University School of Medicine, 1365 C Clifton Road NE, Atlanta, GA, 30322, USA
    Mol Cell Biochem 391:157-66. 2014
  8. doi request reprint The role of regucalcin in bone homeostasis: involvement as a novel cytokine
    Masayoshi Yamaguchi
    Department of Hematology and Medical Oncology, Emory University School of Medicine, 1365 C Clifton Road NE, Atlanta, GA 30322, USA
    Integr Biol (Camb) 6:258-66. 2014
  9. pmc Bioactive flavonoid p-hydroxycinnamic acid stimulates osteoblastogenesis and suppresses adipogenesis in bone marrow culture
    Masayoshi Yamaguchi
    Department of Hematology and Biomedical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, 30322, USA
    Cell Tissue Res 354:743-50. 2013
  10. ncbi request reprint Role of regucalcin in cell nuclear regulation: involvement as a transcription factor
    Masayoshi Yamaguchi
    Department of Hematology and Biomedical Oncology, Emory University School of Medicine, 1365 C Clifton Road, NE, Atlanta, GA, 30322, USA
    Cell Tissue Res 354:331-41. 2013

Collaborators

Detail Information

Publications93

  1. ncbi request reprint Role of endogenous regucalcin in bone metabolism: bone loss is induced in regucalcin transgenic rats
    Masayoshi Yamaguchi
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Japan
    Int J Mol Med 10:377-83. 2002
    ..Regucalcin may be involved in the regulation of bone metabolism...
  2. ncbi request reprint Role of albumin in osteoblastic cells: enhancement of cell proliferation and suppression of alkaline phosphatase activity
    Koichi Ishida
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Int J Mol Med 14:1077-81. 2004
    ..0 mg/ml). This study demonstrated that albumin had a role in the regulation of osteoblastic cell function...
  3. ncbi request reprint beta-cryptoxanthin stimulates cell differentiation and mineralization in osteoblastic MC3T3-E1 cells
    Satoshi Uchiyama
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    J Cell Biochem 95:1224-34. 2005
    ..This study demonstrates that beta-cryptoxanthin has a stimulatory effect on cell differentiation and mineralization due to enhancing gene expression of proteins, which involve in bone formation in osteoblastic MC3T3-E1 cells...
  4. ncbi request reprint Effects of flavonoid on calcium content in femoral tissue culture and parathyroid hormone-stimulated osteoclastogenesis in bone marrow culture in vitro
    Masayoshi Yamaguchi
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Shizuoka, Japan
    Mol Cell Biochem 303:83-8. 2007
    ..Among various flavonoids, quercetin had a stimulatory effect on bone formation and an inhibitory effect on bone resorption in vitro...
  5. doi request reprint Vitamin K2 stimulates osteoblastogenesis and suppresses osteoclastogenesis by suppressing NF-κB activation
    Masayoshi Yamaguchi
    Emory University School of Medicine, 101 Woodruff Circle, 1329 WMRB, Atlanta, GA 30322, USA
    Int J Mol Med 27:3-14. 2011
    ....
  6. ncbi request reprint Curcumin analogue UBS109 prevents bone loss in breast cancer bone metastasis mouse model: involvement in osteoblastogenesis and osteoclastogenesis
    Masayoshi Yamaguchi
    Department of Hematology and Medical Oncology, Emory University School of Medicine, 1365 C Clifton Road NE, Atlanta, GA, 30322, USA
    Cell Tissue Res 357:245-52. 2014
    ..These findings suggest that the novel curcumin analogue UBS109 prevents breast cancer cell bone metastasis-induced bone loss by stimulating osteoblastic mineralization and suppressing osteoclastogenesis. ..
  7. ncbi request reprint Regucalcin as a potential biomarker for metabolic and neuronal diseases
    Masayoshi Yamaguchi
    Department of Hematology and Medical Oncology, Emory University School of Medicine, 1365 C Clifton Road NE, Atlanta, GA, 30322, USA
    Mol Cell Biochem 391:157-66. 2014
    ..Moreover, regucalcin has been shown to be good tool in early diagnosis for Alzheimer's disease and other brain diseases. This review will discuss a significance of regucalcin as a clinical biomarker in various diseases. ..
  8. doi request reprint The role of regucalcin in bone homeostasis: involvement as a novel cytokine
    Masayoshi Yamaguchi
    Department of Hematology and Medical Oncology, Emory University School of Medicine, 1365 C Clifton Road NE, Atlanta, GA 30322, USA
    Integr Biol (Camb) 6:258-66. 2014
    ..Exogenous regucalcin may play a pivotal role in the regulation of bone homeostasis as a suppressor in osteoblastogenesis and an enhancer in osteoclastogenesis, suggesting its role as a cytokine. ..
  9. pmc Bioactive flavonoid p-hydroxycinnamic acid stimulates osteoblastogenesis and suppresses adipogenesis in bone marrow culture
    Masayoshi Yamaguchi
    Department of Hematology and Biomedical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, 30322, USA
    Cell Tissue Res 354:743-50. 2013
    ..Such effects of HCA might be involved in the differentiation of mesenchymal stem cells. ..
  10. ncbi request reprint Role of regucalcin in cell nuclear regulation: involvement as a transcription factor
    Masayoshi Yamaguchi
    Department of Hematology and Biomedical Oncology, Emory University School of Medicine, 1365 C Clifton Road, NE, Atlanta, GA, 30322, USA
    Cell Tissue Res 354:331-41. 2013
    ..This review will discuss the role of regucalcin in the regulation of cell nuclear function and an involvement in gene expression as a novel transcription factor. ..
  11. pmc The anti-apoptotic effect of regucalcin is mediated through multisignaling pathways
    Masayoshi Yamaguchi
    Department of Hematology and Biomedical Oncology, Emory University School of Medicine, 1365 C Clifton Road, Atlanta, GA, 30322, USA
    Apoptosis 18:1145-53. 2013
    ..This review discusses that regucalcin plays a pivotal role in rescue of apoptotic cell death, which is mediated through various signaling factors. ..
  12. doi request reprint Involvement of regucalcin in lipid metabolism and diabetes
    Masayoshi Yamaguchi
    Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX 77030, USA
    Metabolism 62:1045-51. 2013
    ..Decrease in hepatic regucalcin is associated with the development and progression of nonalcoholic fatty liver disease and fibrosis in human patients. Regucalcin may be a key molecule in lipid metabolic disorder and diabetes...
  13. doi request reprint Suppressive role of regucalcin in liver cell proliferation: involvement in carcinogenesis
    M Yamaguchi
    Department of Hematology and Biomedical Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cell Prolif 46:243-53. 2013
    ..Depression of regucalcin expression may be associated with activity progression of carcinogens. Regucalcin may be a key molecule suppressor protein in cell proliferation and carcinogenesis...
  14. ncbi request reprint Exogenous regucalcin suppresses osteoblastogenesis and stimulates adipogenesis in mouse bone marrow culture
    Masayoshi Yamaguchi
    Department of Veterinary Pathobiology, The University of Missouri Columbia, 1600 East Rollins Street, Columbia, MO 65211, USA
    Integr Biol (Camb) 4:1215-22. 2012
    ..Moreover, exogenous regucalcin was found to enhance adipogenesis stimulated by insulin which is involved in the extracellular signal-related kinase pathway in 3T3-L1 adipocytes in vitro...
  15. doi request reprint The bone anabolic carotenoid p-hydroxycinnamic acid promotes osteoblast mineralization and suppresses osteoclast differentiation by antagonizing NF-κB activation
    Masayoshi Yamaguchi
    Division of Endocrinology and Metabolism and Lipids, Emory University School of Medicine, Atlanta, GA 30322, USA
    Int J Mol Med 30:708-12. 2012
    ..Our data provide a mechanism to explain the dual pro-anabolic and anti-catabolic activities of HCA...
  16. doi request reprint Role of regucalcin in brain calcium signaling: involvement in aging
    Masayoshi Yamaguchi
    Department of Foods and Nutrition, The University of Georgia, 425 River Road, Rhodes Center, Room 448, Athens, GA 30602 2771, USA
    Integr Biol (Camb) 4:825-37. 2012
    ..These inhibitory effects of regucalcin were weakened with aging. Regucalcin may play a pivotal role in the regulation of Ca(2+) signaling which is stimulated through a neurotransmitter in the brain neurons with aging...
  17. doi request reprint Novel curcumin analogue UBS109 potently stimulates osteoblastogenesis and suppresses osteoclastogenesis: involvement in Smad activation and NF-κB inhibition
    Masayoshi Yamaguchi
    Department of Foods and Nutrition, The University of Georgia, 425 River Road, Rhodes Center, Room 448, Athens, GA 30602 2771, USA
    Integr Biol (Camb) 4:905-13. 2012
    ..In the present study, curcumin analogue UBS109 was found to have a stimulating effect on osteoblastogenesis and a suppressive effect on osteoclastogenesis in vitro, suggesting an anabolic effect of the compound on bone mass...
  18. doi request reprint Nutritional factors and bone homeostasis: synergistic effect with zinc and genistein in osteogenesis
    Masayoshi Yamaguchi
    Department of Foods and Nutrition, The University of Georgia, 425 River Road, Rhodes Center, Room 448, Athens, GA 30602 2771, USA
    Mol Cell Biochem 366:201-21. 2012
    ..Supplemental intake of ingredient with the combination of zinc and genistein has been shown to have a preventive effect on osteoporosis in human subjects, suggesting a role in the prevention of bone loss...
  19. pmc Role of carotenoid β-cryptoxanthin in bone homeostasis
    Masayoshi Yamaguchi
    Department of Foods and Nutrition, The University of Georgia, Athens, GA 30602 2771, USA
    J Biomed Sci 19:36. 2012
    ..Cryptoxanthin may be an osteogenic factor in preventing osteoporosis in human subjects...
  20. doi request reprint Role of nutritional zinc in the prevention of osteoporosis
    Masayoshi Yamaguchi
    Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322 0001, USA
    Mol Cell Biochem 338:241-54. 2010
    ..Zinc compounds may be designed as new supplementation factor in the prevention and therapy of osteoporosis...
  21. ncbi request reprint The bone anabolic carotenoid beta-cryptoxanthin enhances transforming growth factor-beta1-induced SMAD activation in MC3T3 preosteoblasts
    Masayoshi Yamaguchi
    Division of Endocrinology and Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, 1329 WMRB, Atlanta, GA 30322 0001, USA
    Int J Mol Med 24:671-5. 2009
    ..This study suggests that the carotenoid beta-cryptoxanthin may promote osteoblast differentiation and activity by amplifying TGF-beta1-induced lineage commitment of osteoblast precursors...
  22. doi request reprint Oral administration of phytocomponent p-hydroxycinnamic acid prevents bone loss in ovariectomized rats
    Masayoshi Yamaguchi
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Mol Cell Biochem 311:31-6. 2008
    ..These increases were significantly restored after oral administration of HCA (500 microg/100 g). This study demonstrates that HCA has preventive effects on OVX-induced bone loss of rats in vivo...
  23. doi request reprint Novel protein RGPR-p117: its role as the regucalcin gene transcription factor
    Masayoshi Yamaguchi
    Division of Endocrinology and Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, 101 Woodruff Circle, 1305 WMRB, Atlanta, GA 30322 0001, USA
    Mol Cell Biochem 327:53-63. 2009
    ..The novel protein RGPR-p117 has been shown to play an important role as a transcription factor...
  24. ncbi request reprint The estrogen 17beta-estradiol and phytoestrogen genistein mediate differential effects on osteoblastic NF-kappaB activity
    Masayoshi Yamaguchi
    Division of Endocrinology and Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322 0001, USA
    Int J Mol Med 23:297-301. 2009
    ..These data suggest important mechanistic differences in the mechanisms by which 17beta-estradiol and genistein promote osteoblast differentiation...
  25. ncbi request reprint Overexpression of RGPR-p117 suppresses apoptotic cell death and its related gene expression in cloned normal rat kidney proximal tubular epithelial NRK52E cells
    Masayoshi Yamaguchi
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Int J Mol Med 20:565-71. 2007
    ..This study also demonstrates that RGPR-p117 regulates the gene expression of apoptosis-related proteins...
  26. ncbi request reprint Phytocomponent p-hydroxycinnamic acid stimulates mineralization in osteoblastic MC3T3-E1 cells
    Masayoshi Yamaguchi
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Int J Mol Med 22:287-91. 2008
    ..This study demonstrates that HCA has stimulatory effects on mineralization in osteoblastic MC3T3-E1 cells...
  27. ncbi request reprint Hormonal regulation of regucalcin mRNA expression in osteoblastic MC3T3-E1 cells
    Masayoshi Yamaguchi
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Int J Mol Med 21:771-5. 2008
    ..This study demonstrated that regucalcin mRNA expression in osteoblastic MC3T3-E1 cells is regulated by various hormones...
  28. ncbi request reprint Combination of beta-cryptoxanthin and zinc has potent effects on apoptotic cell death and suppression of bone resorption-related gene expression in osteoclastic cells
    Masayoshi Yamaguchi
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka, Japan
    Int J Mol Med 22:221-8. 2008
    ..This study demonstrated that the combination of CRP and zinc has potent suppressive effects on osteoclastic cells in vitro...
  29. doi request reprint Regucalcin increases Ca2+-ATPase activity in the mitochondria of brain tissues of normal and transgenic rats
    Masayoshi Yamaguchi
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    J Cell Biochem 104:795-804. 2008
    ..This study demonstrates that regucalcin has a role in the regulation of Ca(2+)-ATPase activity in the brain mitochondria of rats...
  30. doi request reprint Effect of zinc on gene expression in osteoblastic MC3T3-E1 cells: enhancement of Runx2, OPG, and regucalcin mRNA expressions
    Masayoshi Yamaguchi
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Mol Cell Biochem 312:157-66. 2008
    ..This study demonstrates that zinc sulfate has a role in the enhancement of Runx2, OPG, or regucalcin mRNA expression in osteoblastic cells in vitro, suggesting its role in the regulation of gene expression in the cells...
  31. doi request reprint The transcriptional regulation of regucalcin gene expression
    Masayoshi Yamaguchi
    Division of Endocrinology and Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, 101 Woodruff Circle, 1305 WMRB, Atlanta, GA 30322 0001, USA
    Mol Cell Biochem 346:147-71. 2011
    ..Serum regucalcin has a potential sensitivity as a specific biochemical marker of chronic liver injury with hepatitis. Regucalcin has been proposed to be a key molecule in cellular regulation and metabolic disease...
  32. doi request reprint Regucalcin and cell regulation: role as a suppressor protein in signal transduction
    Masayoshi Yamaguchi
    Division of Endocrinology and Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, 101 Woodruff Circle, 1305 WMRB, Atlanta, GA 30322 0001, USA
    Mol Cell Biochem 353:101-37. 2011
    ..Regucalcin plays an important role as a regulatory protein in cell signaling system, and it is proposed to play a pivotal role in keep of cell homeostasis and function...
  33. doi request reprint The bone anabolic carotenoids p-hydroxycinnamic acid and β-cryptoxanthin antagonize NF-κB activation in MC3T3 preosteoblasts
    Masayoshi Yamaguchi
    Division of Endocrinology and Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322 0001, USA
    Mol Med Report 2:641-4. 2009
    ..The data obtained suggest that NF-κB may be a common molecular target by which several bone active agents, including carotenoids, promote osteoblastic bone formation...
  34. doi request reprint Zinc stimulates osteoblastogenesis and suppresses osteoclastogenesis by antagonizing NF-κB activation
    Masayoshi Yamaguchi
    Division of Endocrinology and Metabolism and Lipids, Department of Medicine, 101 Woodruff Circle, 1329 WMRB, Atlanta, GA 30322, USA
    Mol Cell Biochem 355:179-86. 2011
    ..In conclusion, our data reveal for the first time that a major mechanism by which zinc promotes osteoblastogenesis and suppresses osteoclastogenesis may center on the antagonism of NF-κB activation...
  35. doi request reprint Quercetin, a potent suppressor of NF-κB and Smad activation in osteoblasts
    Masayoshi Yamaguchi
    Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Int J Mol Med 28:521-5. 2011
    ....
  36. doi request reprint Exogenous regucalcin stimulates osteoclastogenesis and suppresses osteoblastogenesis through NF-κB activation
    Masayoshi Yamaguchi
    Department of Medicine, Division of Endocrinology and Metabolism and Lipids, Emory University School of Medicine, 101 Woodruff Circle, 1329 WMRB, Atlanta, GA 30322, USA
    Mol Cell Biochem 359:193-203. 2012
    ..Regucalcin may have a role as a modulator in NF-κB activation...
  37. ncbi request reprint Regucalcin and metabolic disorders: osteoporosis and hyperlipidemia are induced in regucalcin transgenic rats
    Masayoshi Yamaguchi
    Division of Endocrinology and Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, 101 Woodruff Circle, 1305 WMRB, Atlanta, GA 30322 0001, USA
    Mol Cell Biochem 341:119-33. 2010
    ....
  38. ncbi request reprint Overexpression of regucalcin suppresses cell proliferation of cloned normal rat kidney proximal tubular epithelial NRK52E cells
    Taeko Nakagawa
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Mol Med 16:637-43. 2005
    ..This study demonstrates that overexpression of regucalcin has a suppressive effect on cell proliferation, which is mediated through various signaling pathways, in the cloned normal rat kidney proximal tubular epithelial NRK52E cells...
  39. ncbi request reprint Role of endogenous regucalcin in transgenic rats: suppression of kidney cortex cytosolic protein phosphatase activity and enhancement of heart muscle microsomal Ca2+-ATPase activity
    Masayoshi Yamaguchi
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    J Cell Biochem 86:520-9. 2002
    ..Regucalcin TG rats should be a useful model to define a regulatory role of endogenous regucalcin in the tissues in vivo...
  40. ncbi request reprint beta-Cryptoxanthin stimulates bone formation and inhibits bone resorption in tissue culture in vitro
    Masayoshi Yamaguchi
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Yada, Shizuoka, Japan
    Mol Cell Biochem 258:137-44. 2004
    ..The present study demonstrates that beta-cryptoxanthin has a direct stimulatory effect on bone formation and an inhibitory effect on bone resorption in tissue culture in vitro...
  41. ncbi request reprint Overexpression of RGPR-p117 enhances regucalcin gene expression in cloned normal rat kidney proximal tubular epithelial cells
    Natsumi Sawada
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Int J Mol Med 16:1049-55. 2005
    ..This study demonstrates that overexpression of RGPR-p117 enhances the expression of regucalcin mRNA and its protein level in NRK52E cells. RGPR-p117 may play a role as a transcriptional factor...
  42. ncbi request reprint Role of regucalcin in liver nuclear function: binding of regucalcin to nuclear protein or DNA and modulation of tumor-related gene expression
    Yoshinori Tsurusaki
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka, Japan
    Int J Mol Med 14:277-81. 2004
    ..This study may support the view that regucalcin modulates the transcriptional process by binding to protein and DNA in the nucleus...
  43. ncbi request reprint Characterization of protein tyrosine phosphatase activity in rat liver microsomes: suppressive effect of endogenous regucalcin in transgenic rats
    Yuko Fukaya
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka, Japan
    Int J Mol Med 14:427-32. 2004
    ..This study demonstrates that protein tyrosine phosphatase activity is found in the liver microsomes, and that the enzyme activity is suppressed by regucalcin...
  44. ncbi request reprint Bone loss in regucalcin transgenic rats: enhancement of osteoclastic cell formation from bone marrow of rats with increasing age
    Satoshi Uchiyama
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Int J Mol Med 14:451-5. 2004
    ..This study demonstrates that osteoclastic bone resorption is stimulated in regucalcin TG male and female rats with increasing age...
  45. ncbi request reprint Overexpression of RGPR-p117 enhances regucalcin gene promoter activity in cloned normal rat kidney proximal tubular epithelial cells: involvement of TTGGC motif
    Natsumi Sawada
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Suruga Ward, Shizuoka 422 8526, Japan
    J Cell Biochem 99:589-97. 2006
    ....
  46. ncbi request reprint Regulatory effect of regucalcin on nitric oxide synthase activity in rat kidney cortex cytosol: Role of endogenous regucalcin in transgenic rats
    Zhong Jie Ma
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka, Japan
    Int J Mol Med 12:201-6. 2003
    ..The present study demonstrates that endogenous regucalcin has a suppressive effect on NO synthase activity in the kidney cortex cytosol of rats...
  47. ncbi request reprint Suppressive role of endogenous regucalcin in the enhancement of nitric oxide synthase activity in liver cytosol of normal and regucalcin transgenic rats
    Masayoshi Yamaguchi
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    J Cell Biochem 88:1226-34. 2003
    ..The present study demonstrated that endogenous regucalcin plays a suppressive role in the enhancement of NO synthase activity in the liver cytosol of rats...
  48. ncbi request reprint Regucalcin increases Ca2+-ATPase activity in the heart mitochondria of normal and regucalcin transgenic rats
    Tania Akhter
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Int J Mol Med 18:171-6. 2006
    ..This study demonstrates that regucalcin has an activating effect on Ca2+-ATPase in rat heart mitochondria, suggesting its role in the regulation of heart mitochondrial function...
  49. ncbi request reprint Oral administration of phytocomponent p-hydroxycinnamic acid has a preventive effect on bone loss in streptozotocin-induced diabetic rats
    Masayoshi Yamaguchi
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka, Japan
    Int J Mol Med 19:803-7. 2007
    ..This study demonstrates that the intake of HCA has preventive effects on bone loss in STZ-diabetic rats, and that the intake has partially restorative effects on serum biochemical findings in the diabetic state...
  50. ncbi request reprint Involvement of nuclear factor I-A1 in the regulation of regucalcin gene promoter activity in cloned normal rat kidney proximal tubular epithelial cells
    Natsumi Sawada
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Int J Mol Med 18:665-71. 2006
    ..This study demonstrates that NF1-A1 enhances the regucalcin promoter activity which is related to the TTGGC motif, and that its enhancing effect is partly mediated through phosphorylation in NRK52E cells...
  51. ncbi request reprint Oral administration in combination with zinc enhances beta-cryptoxanthin-induced anabolic effects on bone components in the femoral tissues of rats in vivo
    Masayoshi Yamaguchi
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Biol Pharm Bull 29:371-4. 2006
    ..5 mg/100 g). This study demonstrates that the oral administration of the combination of zinc at lower doses synergistically enhances beta-cryptoxanthin-induced anabolic effects on bone components in the femoral tissues of rats in vivo...
  52. ncbi request reprint Effects of copper on bone component in the femoral tissues of rats: anabolic effect of zinc is weakened by copper
    Ying Ling Lai
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Japan
    Biol Pharm Bull 28:2296-301. 2005
    ..This study demonstrates that supplementation with copper in adequate copper nutrition does not have anabolic effects on bone components in vivo and in vitro and that copper weakens the anabolic effects of zinc in vitro...
  53. ncbi request reprint Overexpression of regucalcin suppresses cell death and apoptosis in cloned rat hepatoma H4-II-E cells induced by lipopolysaccharide, PD 98059, dibucaine, or Bay K 8644
    Takako Izumi
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    J Cell Biochem 93:598-608. 2004
    ..This study demonstrates that overexpression of regucalcin has a suppressive effect on cell death induced by LPS or various intracellular signaling-related factors...
  54. ncbi request reprint Overexpression of regucalcin suppresses apoptotic cell death in cloned normal rat kidney proximal tubular epithelial NRK52E cells: change in apoptosis-related gene expression
    Taeko Nakagawa
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    J Cell Biochem 96:1274-85. 2005
    ....
  55. ncbi request reprint Synergistic effect of beta-cryptoxanthin and zinc sulfate on the bone component in rat femoral tissues in vitro: the unique anabolic effect with zinc
    Satoshi Uchiyama
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Japan
    Biol Pharm Bull 28:2142-5. 2005
    ..This study demonstrates that the combination of beta-cryptoxanthin and zinc at a lower concentration has a synergistic effect on bone components in vitro...
  56. ncbi request reprint Albumin regulates Runx2 and alpha1 (I) collagen mRNA expression in osteoblastic cells: comparison with insulin-like growth factor-I
    Koichi Ishida
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Mol Med 16:689-94. 2005
    ..This study demonstrates that albumin has a role in the regulation of Runx2 or alpha1 (I) collagen mRNA expression, which may be mediated through intracellular signaling pathway, in osteoblastic cells...
  57. ncbi request reprint Regucalcin increases superoxide dismutase activity in the heart cytosol of normal and regucalcin transgenic rats
    Emiko Ichikawa
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Int J Mol Med 14:691-5. 2004
    ..This study demonstrates that regucalcin increases SOD activity in the heart cytosol of rats, and that its effect is not related to the sulfhydryl group of enzymes...
  58. ncbi request reprint Nuclear localization of a novel protein, RGPR-p117, in cloned normal rat kidney proximal tubular epithelial cells
    Natsumi Sawada
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Yada, Shizuoka 422 8526, Japan
    Int J Mol Med 16:809-14. 2005
    ..This study demonstrates that RGPR-p117 is localized in the nucleus of kidney cells, and may be involved in gene expression...
  59. ncbi request reprint Inhibitory effect of menaquinone-7 (vitamin K2) on the bone-resorbing factors-induced bone resorption in elderly female rat femoral tissues in vitro
    Masayoshi Yamaguchi
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka, Japan
    Mol Cell Biochem 245:115-20. 2003
    ..These results support the view that MK-7 has a direct inhibitory effect on the bone-resorbing factor-induced bone resorption in bone culture using female aged femoral tissues in vitro...
  60. ncbi request reprint Inhibitory role of regucalcin in the regulation of nitric oxide synthase activity in rat brain cytosol: involvement of aging
    Minako Tobisawa
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Shizuoka, 422 8526, Japan
    J Neurol Sci 209:47-54. 2003
    ..This elevation was completely blocked by the addition of regucalcin (10(-8) M). The present study demonstrates that endogenous regucalcin has an inhibitory effect on NO synthase activity in the brain cytosol of young and aged rats...
  61. ncbi request reprint Regucalcin increases superoxide dismutase activity in rat liver cytosol
    Yuko Fukaya
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Biol Pharm Bull 27:1444-6. 2004
    ..0 mM). The effect of regucalcin in increasing SOD activity may not involve the sulfhydryl group of SOD. This study demonstrates that regucalcin has an activatory effect on SOD in the liver cytosol of rats...
  62. ncbi request reprint Phytocomponent p-hydroxycinnamic acid stimulates bone formation and inhibits bone resorption in rat femoral tissues in vitro
    Ying Ling Lai
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Mol Cell Biochem 292:45-52. 2006
    ..This study demonstrates that p-hydroxycinnamic acid (HCA) has stimulatory effects on bone formation and inhibitory effects on bone resorption in tissue culture in vitro...
  63. ncbi request reprint Role of endogenous regucalcin in brain function: suppression of cytosolic nitric oxide synthase and nuclear protein tyrosine phosphatase activities in brain tissue of transgenic rats
    Minako Tobisawa
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Int J Mol Med 12:581-5. 2003
    ..The increase was significantly prevented in the brain cytosol and nucleus of TG rats. The present study supports the view that endogenous regucalcin plays a suppressive role in the regulation of brain function in rats...
  64. ncbi request reprint Suppressive effect of endogenous regucalcin on nitric oxide synthase activity in cloned rat hepatoma H4-II-E cells overexpressing regucalcin
    Takako Izumi
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    J Cell Biochem 89:800-7. 2003
    ..The present study demonstrates that endogenous regucalcin has a suppressive effect on NO synthase activity in the cloned rat hepatoma H4-II-E cells...
  65. ncbi request reprint Expression of regucalcin in rat bone marrow cells: involvement of osteoclastic bone resorption in regucalcin transgenic rats
    Masayoshi Yamaguchi
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Int J Mol Med 13:437-43. 2004
    ..Also, regucalcin TG aged rats was found to induce serum metabolic disorder...
  66. ncbi request reprint Suppressive effect of regucalcin on protein phosphatase activity in the heart cytosol of normal and regucalcin transgenic rats
    Emiko Ichikawa
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Int J Mol Med 13:289-93. 2004
    ..This study demonstrates that endogenous regucalcin plays a suppressive role in the regulation of protein phosphatase activity in rat heart cytoplasm...
  67. ncbi request reprint Receptor activator of NF-kappaB ligand-stimulated osteoclastogenesis in mouse marrow culture is suppressed by zinc in vitro
    Masayoshi Yamaguchi
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Int J Mol Med 14:81-5. 2004
    ..These results suggest that the inhibitory action of zinc on osteoclastogenesis is partly due to suppressing signaling pathway which is related to RANKL stimulation in osteoclast development...
  68. ncbi request reprint Overexpression of RGPR-p117 induces the decrease in protein and DNA contents in cloned normal rat kidney proximal tubular epithelial NRK52E cells
    Susumu Tomono
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka, Japan
    Int J Mol Med 20:79-83. 2007
    ..This study demonstrates that overexpression of RGPR-p117 induces the decrease in protein and DNA contents in NK52E cells, indicating its role in the regulation of cell function...
  69. ncbi request reprint Novel protein RGPR-p117: the gene expression in physiologic state and the binding activity to regucalcin gene promoter region in rat liver
    Masayoshi Yamaguchi
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka, Japan
    J Cell Biochem 88:1092-100. 2003
    ..This study demonstrates that RGPR-p117 mRNA, is expressed stably for physiologic change in rat liver, and that recombinant the protein does not directly bind to the TTGGC motif in rat regucalcin gene promoter...
  70. ncbi request reprint Suppressive effect of regucalcin on cell differentiation and mineralization in osteoblastic MC3T3-E1 cells
    Masayoshi Yamaguchi
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    J Cell Biochem 96:543-54. 2005
    ..This study demonstrates that regucalcin regulates the function of osteoblastic cells, and that the protein suppresses cell differentiation and mineralization...
  71. ncbi request reprint Oral administration of beta-cryptoxanthin prevents bone loss in ovariectomized rats
    Satoshi Uchiyama
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Int J Mol Med 17:15-20. 2006
    ..These decreases were significantly prevented by the administration of beta-cryptoxanthin (5 or 10 microg/100 g). This study demonstrates that beta-cryptoxanthin has a preventive effect on OVX-induced bone loss in vivo...
  72. ncbi request reprint Genistein and zinc synergistically stimulate apoptotic cell death and suppress RANKL signaling-related gene expression in osteoclastic cells
    Satoshi Uchiyama
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    J Cell Biochem 101:529-42. 2007
    ..This study demonstrates that the combination of genistein and zinc has potent stimulatory effects on apoptotic cell death and suppressive effects on osteoclastic cell function...
  73. ncbi request reprint Anabolic effect of beta-cryptoxanthin in osteoblastic MC3T3-E1 cells is enhanced with 17beta-estradiol, genistein, or zinc sulfate in vitro: the unique effect with zinc on Runx2 and alpha1(I) collagen mRNA expressions
    Satoshi Uchiyama
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka, Japan
    Mol Cell Biochem 307:209-19. 2008
    ..Thus, the anabolic effect of CRP in osteoblastic MC3T3-E1 cells was modulated with a specific factor...
  74. ncbi request reprint Role of endogenous regucalcin in transgenic rats: suppression of protein tyrosine phosphatase and ribonucleic acid synthesis activities in liver nucleus
    Yoshinori Tsurusaki
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka, Japan
    Int J Mol Med 12:207-11. 2003
    ..These results suggest that endogenous regucalcin plays a suppressive role in the regulation of liver nuclear function in rats...
  75. ncbi request reprint Genistein and zinc synergistically enhance gene expression and mineralization in osteoblastic MC3T3-E1 cells
    Satoshi Uchiyama
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Mol Med 19:213-20. 2007
    ..This study demonstrates that the combination of genistein and zinc can synergistically enhance gene expression and mineralization in osteoblastic cells...
  76. ncbi request reprint Role of endogenous regucalcin in nuclear regulation of regenerating rat liver: suppression of the enhanced ribonucleic acid synthesis activity
    Yoshinori Tsurusaki
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Yada, Shizuoka, Japan
    J Cell Biochem 87:450-7. 2002
    ..The present study demonstrates that endogenous regucalcin has a suppressive effect on the enhancement of RNA synthesis activity in the nucleus of regenerating rat liver with proliferative cells...
  77. ncbi request reprint Regucalcin stimulates osteoclast-like cell formation in mouse marrow cultures
    Masayoshi Yamaguchi
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    J Cell Biochem 94:794-803. 2005
    ..This study demonstrates that regucalcin directly stimulates osteoclast-like cell formation in mouse marrow culture in vitro, and that the protein stimulates bone resorption in rat femoral tissues in vitro...
  78. ncbi request reprint Overexpression of regucalcin enhances its nuclear localization and suppresses L-type Ca2+ channel and calcium-sensing receptor mRNA expressions in cloned normal rat kidney proximal tubular epithelial NRK52E cells
    Taeko Nakagawa
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    J Cell Biochem 99:1064-77. 2006
    ....
  79. ncbi request reprint beta-Cryptoxanthin stimulates cell proliferation and transcriptional activity in osteoblastic MC3T3-E1 cells
    Satoshi Uchiyama
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Int J Mol Med 15:675-81. 2005
    ..This study demonstrates that beta-cryptoxanthin has a stimulatory effect on cell proliferation and biochemical components in osteoclastic MC3T3-E1 cells, and that the carotenoid can stimulate transcriptional activity in the cells...
  80. ncbi request reprint Overexpression of regucalcin suppresses cell response for tumor necrosis factor-alpha or transforming growth factor-beta1 in cloned normal rat kidney proximal tubular epithelial NRK52E cells
    Taeko Nakagawa
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    J Cell Biochem 100:1178-90. 2007
    ..This study demonstrates that overexpression of regucalcin has suppressive effects on cell responses which are mediated through intracellular signaling pathways of TNF-alpha or TGF-beta1 in kidney NRK52E cells...
  81. ncbi request reprint Overexpression of regucalcin suppresses cell death in cloned rat hepatoma H4-II-E cells induced by tumor necrosis factor-alpha or thapsigargin
    Takako Izumi
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    J Cell Biochem 92:296-306. 2004
    ..This study demonstrates that overexpression of regucalcin has a suppressive effect on cell death induced by TNF-alpha or thapsigargin...
  82. ncbi request reprint Beta-cryptoxanthin stimulates apoptotic cell death and suppresses cell function in osteoclastic cells: change in their related gene expression
    Satoshi Uchiyama
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    J Cell Biochem 98:1185-95. 2006
    ..This study demonstrates that beta-cryptoxanthin has stimulatory effects on apoptotic cell death and suppressive effects on osteoclastic cell function...
  83. ncbi request reprint Regulatory effect of exogenous regucalcin on cell function in osteoblastic MC3T3-E1 cells: involvement of intracellular signaling factor
    Yasuko Otomo
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Int J Mol Med 18:321-7. 2006
    ..This study supports the view that exogenous regucalcin regulates the function of osteoblastic cells, and that the effect of protein is mediated through signaling factors...
  84. ncbi request reprint [Fluoride and bone metabolism]
    Masayoshi Yamaguchi
    University of Shizuoka, Graduate School of Nutritional Sciences, Laboratory of Endocrinology and Molecular Metabolism
    Clin Calcium 17:217-23. 2007
    ..Moreover, the intake of F with comparatively low doses may have beneficial effects in the development of bone mineral density and fracture in human...
  85. ncbi request reprint Role of regucalcin as an activator of sarcoplasmic reticulum Ca2+-ATPase activity in rat heart muscle
    Masayoshi Yamaguchi
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    J Cell Biochem 86:184-93. 2002
    ..The present study demonstrates that regucalcin can activate Ca(2+) pump activity in rat heart microsomes, and that the protein may act the SH groups of Ca(2+)-ATPase by binding to microsomal membranes...
  86. ncbi request reprint Regulatory mechanism of food factors in bone metabolism and prevention of osteoporosis
    Masayoshi Yamaguchi
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka City 422 8526, Japan
    Yakugaku Zasshi 126:1117-37. 2006
    ..Phytocomponent p-hydroxycinnamic acid was also found to have an anabolic effect on bone metabolism. Food chemical factors thus play a role in bone health and may be important in the prevention of bone loss with increasing age...
  87. ncbi request reprint Suppressive role of endogenous regucalcin in the enhancement of deoxyribonucleic acid synthesis activity in the nucleus of regenerating rat liver
    Yoshinori Tsurusaki
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    J Cell Biochem 85:516-22. 2002
    ..The present study suggests that endogenous regucalcin plays a suppressive role in the enhancement of nuclear DNA synthesis activity in regenerating liver with cell proliferation after partial hepatectomy in rats...
  88. ncbi request reprint Hormonal regulation on regucalcin mRNA expression in cloned normal rat kidney proximal tubular epithelial NRK52E cells
    Taeko Nakagawa
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    J Cell Biochem 95:589-97. 2005
    ....
  89. ncbi request reprint Expression of albumin in bone tissues and osteoblastic cells: involvement of hormonal regulation
    Koichi Ishida
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Int J Mol Med 14:891-5. 2004
    ..This study demonstrates that albumin is expressed in bone marrow cells and osteoblastic cells, and that the production of albumin in osteoblastic cells is enhanced by various bone anabolic factors in vitro...
  90. ncbi request reprint Change in lipid components in the adipose and liver tissues of regucalcin transgenic rats with increasing age: suppression of leptin and adiponectin gene expression
    Masayoshi Yamaguchi
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Int J Mol Med 20:323-8. 2007
    ..This study demonstrates that the disorder of lipid metabolism in the adipose and liver tissues is induced in regucalcin TG rats with aging, and that the gene expression of leptin or adiponectin is suppressed in TG rats...
  91. ncbi request reprint Nuclear localization of regucalcin is enhanced in culture with protein kinase C activation in cloned normal rat kidney proximal tubular epithelial NRK52E cells
    Taeko Nakagawa
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, Shizuoka, Japan
    Int J Mol Med 21:605-10. 2008
    ....
  92. ncbi request reprint Anabolic effect of phosphogenistein and phosphodaidzein on bone components in rat femoral-metaphyseal tissues in vitro
    Masayoshi Yamaguchi
    Laboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    J Bone Miner Metab 20:148-55. 2002
    ..The present study has demonstrated that both phosphogenistein and phosphodaidzein have an anabolic effect on bone metabolism in rat femoral-metaphyseal tissues in vitro...