Toshiaki Watanabe

Summary

Affiliation: Graduate School
Country: Japan

Publications

  1. pmc Chromosome 18q deletion and Smad4 protein inactivation correlate with liver metastasis: A study matched for T- and N- classification
    T Tanaka
    Department of Surgical Oncology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Br J Cancer 95:1562-7. 2006
  2. pmc Single-incision laparoscopic cholecystectomy for cholecystolithiasis coinciding with cavernous transformation of the portal vein: report of a case
    Takuro Shirasu
    Department of Surgery, Kikkoman General Hospital, Chiba, Japan
    BMC Surg 13:10. 2013
  3. pmc Bowel necrosis following endovascular revascularization for chronic mesenteric ischemia: a case report and review of the literature
    Takuro Shirasu
    Division of Vascular Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    BMC Gastroenterol 13:118. 2013
  4. pmc Study protocol of the B-CAST study: a multicenter, prospective cohort study investigating the tumor biomarkers in adjuvant chemotherapy for stage III colon cancer
    Megumi Ishiguro
    Department of Surgical Oncology, Tokyo Medical and Dental University, Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    BMC Cancer 13:149. 2013
  5. ncbi request reprint A 1cm distal bowel margin is safe for rectal cancer after preoperative radiotherapy
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Hepatogastroenterology 59:1068-74. 2012
  6. doi request reprint Time trend and risk factors for reoperation in Crohn's disease in Japan
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Hepatogastroenterology 59:1081-6. 2012
  7. doi request reprint Chromosomal instability (CIN) phenotype, CIN high or CIN low, predicts survival for colorectal cancer
    Toshiaki Watanabe
    Department of Surgical Oncology, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Clin Oncol 30:2256-64. 2012
  8. doi request reprint Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, Tokyo, 173 8605, Japan
    Int J Clin Oncol 17:1-29. 2012
  9. ncbi request reprint Gene expression signature and the prediction of lymph node metastasis in colorectal cancer by DNA microarray
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Dis Colon Rectum 52:1941-8. 2009
  10. doi request reprint A case report of thyroid gland metastasis associated with lung metastasis from colon cancer
    Keisuke Nakamura
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Tumori 97:229-32. 2011

Detail Information

Publications135 found, 100 shown here

  1. pmc Chromosome 18q deletion and Smad4 protein inactivation correlate with liver metastasis: A study matched for T- and N- classification
    T Tanaka
    Department of Surgical Oncology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Br J Cancer 95:1562-7. 2006
    ..Smad4 protein expression level and allelic loss at 18q21 are associated with the process of liver metastasis in colorectal cancers evaluated when excluding clinical and pathological features except for liver metastasis...
  2. pmc Single-incision laparoscopic cholecystectomy for cholecystolithiasis coinciding with cavernous transformation of the portal vein: report of a case
    Takuro Shirasu
    Department of Surgery, Kikkoman General Hospital, Chiba, Japan
    BMC Surg 13:10. 2013
    ..Single-incision laparoscopic cholecystectomy, an emerging procedure for symptomatic cholecystolithiasis, has limitations especially in anatomically complex cases...
  3. pmc Bowel necrosis following endovascular revascularization for chronic mesenteric ischemia: a case report and review of the literature
    Takuro Shirasu
    Division of Vascular Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    BMC Gastroenterol 13:118. 2013
    ..Endovascular revascularization has recently been established as a less invasive treatment method for chronic mesenteric ischemia. However, intestinal necrosis caused by distal embolization following this procedure has not been emphasized...
  4. pmc Study protocol of the B-CAST study: a multicenter, prospective cohort study investigating the tumor biomarkers in adjuvant chemotherapy for stage III colon cancer
    Megumi Ishiguro
    Department of Surgical Oncology, Tokyo Medical and Dental University, Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    BMC Cancer 13:149. 2013
    ..Although efficacy prediction of 5-FU derivatives using expression of 5-FU activation/metabolism enzymes in tumors has been studied, it has not been clinically applied...
  5. ncbi request reprint A 1cm distal bowel margin is safe for rectal cancer after preoperative radiotherapy
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Hepatogastroenterology 59:1068-74. 2012
    ..This study aims to examine whether preoperative radio therapy can reduce the distal safety margin in the treatment of lower rectal cancers...
  6. doi request reprint Time trend and risk factors for reoperation in Crohn's disease in Japan
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Hepatogastroenterology 59:1081-6. 2012
    ....
  7. doi request reprint Chromosomal instability (CIN) phenotype, CIN high or CIN low, predicts survival for colorectal cancer
    Toshiaki Watanabe
    Department of Surgical Oncology, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Clin Oncol 30:2256-64. 2012
    ..To examine whether chromosomal instability (CIN) phenotype, determined by the severity of CIN, can predict survival for stages II and III colorectal cancer (CRC)...
  8. doi request reprint Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, Tokyo, 173 8605, Japan
    Int J Clin Oncol 17:1-29. 2012
    ..Here we present the English version of the JSCCR Guidelines 2010...
  9. ncbi request reprint Gene expression signature and the prediction of lymph node metastasis in colorectal cancer by DNA microarray
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Dis Colon Rectum 52:1941-8. 2009
    ..Our objective here was to identify a set of discriminating genes that can be used for characterization and prediction of lymph node metastasis...
  10. doi request reprint A case report of thyroid gland metastasis associated with lung metastasis from colon cancer
    Keisuke Nakamura
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Tumori 97:229-32. 2011
    ..Histopathological examination revealed a number of metastases of differentiated papillary adenocarcinoma in the thyroid gland from colon cancer...
  11. doi request reprint Gene expression signature and response to the use of leucovorin, fluorouracil and oxaliplatin in colorectal cancer patients
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Clin Transl Oncol 13:419-25. 2011
    ..In order to select patients who would benefit most from this therapy, we aimed to build a predictor for the response to FOLFOX using microarray gene expression profiles of primary CRC samples...
  12. doi request reprint Interval of less than 5 years between the first and second operation is a risk factor for a third operation for Crohn's disease
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Inflamm Bowel Dis 18:17-24. 2012
    ..However, limited data are available with regard to the risk factors for a third operation. We aimed to clarify the risk factors for a third operation for CD...
  13. ncbi request reprint RUNX3 copy number predicts the development of UC-associated colorectal cancer
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, Tokyo 173 8605, Japan
    Int J Oncol 38:201-7. 2011
    ..The present study suggests that RUNX3 might play an important role in the development of UC-Ca...
  14. doi request reprint Differential gene expression signatures between colorectal cancers with and without KRAS mutations: crosstalk between the KRAS pathway and other signalling pathways
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, Itabashi ku, Tokyo 173 8605, Japan
    Eur J Cancer 47:1946-54. 2011
    ....
  15. ncbi request reprint Distal colorectal cancers with microsatellite instability (MSI) display distinct gene expression profiles that are different from proximal MSI cancers
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, Tokyo 173 8605, Japan
    Cancer Res 66:9804-8. 2006
    ..The inactivation form of hMLH, per se, differed between proximal and distal MSI cancers. These results suggested that distal MSI cancers constitute a distinct subgroup of sporadic MSI cancers...
  16. doi request reprint Ulcerative colitis-associated colorectal cancer shows a poorer survival than sporadic colorectal cancer: a nationwide Japanese study
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Inflamm Bowel Dis 17:802-8. 2011
    ..This study aimed to clarify the prognosis and clinicopathological features of UC-CRC in comparison with sporadic CRC in the Japanese population...
  17. ncbi request reprint Gene expression signature and the prediction of ulcerative colitis-associated colorectal cancer by DNA microarray
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, Tokyo 173 8605, Japan
    Clin Cancer Res 13:415-20. 2007
    ..Ulcerative colitis (UC) is associated with a high risk of colorectal cancer. To identify genes that could predict the development of cancer in UC, we conducted a DNA microarray analysis using nonneoplastic rectal mucosa of UC patients...
  18. doi request reprint Prediction of liver metastasis after colorectal cancer using reverse transcription-polymerase chain reaction analysis of 10 genes
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, Tokyo 173 8605, Japan
    Eur J Cancer 46:2119-26. 2010
    ..We developed a 10-gene signature that is closely associated with the development of liver metastasis after colorectal cancer...
  19. ncbi request reprint Prediction of sensitivity of rectal cancer cells in response to preoperative radiotherapy by DNA microarray analysis of gene expression profiles
    Toshiaki Watanabe
    Department of Surgical Oncology, University of Tokyo Hospital, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Cancer Res 66:3370-4. 2006
    ..Global expression profiles of responders and nonresponders may provide insights into the development of novel therapeutic targets...
  20. ncbi request reprint Chemoradiotherapy and adjuvant chemotherapy for rectal cancer
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, Tokyo, 173 8605, Japan
    Int J Clin Oncol 13:488-97. 2008
    ..As well, one metaanalysis has shown the efficacy of oral uracil-tegafur as adjuvant chemotherapy for rectal cancer...
  21. doi request reprint Gene expression signature for recurrence in stage III colorectal cancers
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Cancer 115:283-92. 2009
    ..The authors' objective was to identify a set of discriminating genes that could predict recurrence in stage III colorectal cancer...
  22. ncbi request reprint One-stage completely laparoscopic restorative proctocolectomy for ulcerative colitis complicated with sigmoid colon cancer--a case report
    Toshiaki Watanabe
    Department of Surgery, Teikyo University, Tokyo, Japan
    Minim Invasive Ther Allied Technol 15:253-6. 2006
    ....
  23. doi request reprint Gene expression of vascular endothelial growth factor A, thymidylate synthase, and tissue inhibitor of metalloproteinase 3 in prediction of response to bevacizumab treatment in colorectal cancer patients
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Dis Colon Rectum 54:1026-35. 2011
    ..Regimens containing bevacizumab and 5-fluorouracil have achieved substantial progress in the treatment of colorectal cancer. However, individual responses to bevacizumab vary widely in regard to efficacy and toxicity...
  24. ncbi request reprint Heterogeneity of KRAS status may explain the subset of discordant KRAS status between primary and metastatic colorectal cancer
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, Kaga, Itabashi ku, Tokyo, Japan
    Dis Colon Rectum 54:1170-8. 2011
    ..KRAS status is a useful predictive marker for anti-epidermal growth factor receptor antibody therapy...
  25. doi request reprint Predicting ulcerative colitis-associated colorectal cancer using reverse-transcription polymerase chain reaction analysis
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Clin Colorectal Cancer 10:134-41. 2011
    ..This study aimed to build a predictive model for the development of UC-Ca based on gene expression levels measured by reverse-transcription polymerase chain reaction (RT-PCR) analysis in nonneoplastic rectal mucosa...
  26. doi request reprint Target biopsy or step biopsy? Optimal surveillance for ulcerative colitis: a Japanese nationwide randomized controlled trial
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, Tokyo, 173 8605, Japan
    J Gastroenterol 46:11-6. 2011
    ..The present article gives an introduction to this ongoing randomized controlled trial in Japan...
  27. ncbi request reprint Gene expression of mesenchyme forkhead 1 (FOXC2) significantly correlates with the degree of lymph node metastasis in colorectal cancer
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, Itabashi ku, Tokyo, Japan
    Int Surg 96:207-16. 2011
    ..FOXC2 appears to be involved in determining the aggressiveness of lymph node metastasis in colorectal cancer...
  28. ncbi request reprint A case of marked response to preoperative chemoradiotherapy for rectal cancer with para-aortic lymph node metastasis
    Atsushi Horiuchi
    Department of Surgery, Teikyo University School of Medicine, Itabashi ku, Tokyo, Japan
    Int Surg 96:139-43. 2011
    ..This therapeutic approach of preoperative chemotherapy plus irradiation of the primary lesion and para-aortic lymph nodes has potential as an effective treatment...
  29. ncbi request reprint Selective inhibition of cyclooxygenase-2 inhibits colon cancer cell adhesion to extracellular matrix by decreased expression of beta1 integrin
    Kentaro Yazawa
    Department of Surgical Oncology, Faculty of Medical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Cancer Sci 96:93-9. 2005
    ....
  30. ncbi request reprint Lysophosphatidic acid-induced effects in human colon carcinoma DLD1 cells are partially dependent on transactivation of epidermal growth factor receptor
    Ken Mori
    Department of Surgical Oncology, University of Tokyo Graduate School of Medicine, Tokyo 113 8655, Japan
    J Surg Res 132:56-61. 2006
    ..In this study, we investigated the contribution of EGFR transactivation in LPA-induced responses in colon cancer DLD1 cells...
  31. doi request reprint Mid-term prognosis after endoscopic resection for submucosal colorectal carcinoma: summary of a multicenter questionnaire survey conducted by the colorectal endoscopic resection standardization implementation working group in Japanese Society for Cancer o
    Shiro Oka
    Colorectal Endoscopic Resection Standardization Implementation Working Group in Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan
    Dig Endosc 23:190-4. 2011
    ....
  32. ncbi request reprint The Immunohistochemical expression of endothelial cell differentiation gene-2 receptor in human colorectal adenomas
    Yasuhiro Komuro
    Department of Surgical Oncology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Hepatogastroenterology 50:1770-3. 2003
    ..In the current study, we examined the immunohistochemical expression of EDG-2 in colorectal mucosa and adenoma, and clarified its relation with the clinicopathological features...
  33. doi request reprint Tumor location is a prognostic factor in poorly differentiated adenocarcinoma, mucinous adenocarcinoma, and signet-ring cell carcinoma of the colon
    Soichiro Ishihara
    Department of Surgery, Teikyo University, 2 11 1, Kaga, Itabashi ku, Tokyo, 173 8605, Japan
    Int J Colorectal Dis 27:371-9. 2012
    ....
  34. ncbi request reprint Chromosome 18q deletion as a novel molecular predictor for colorectal cancer with simultaneous hepatic metastasis
    Toshiaki Tanaka
    Department of Surgical Oncology, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Diagn Mol Pathol 18:219-25. 2009
    ..This novel molecular predictor is helpful in identifying patients who would benefit from surgical resection...
  35. ncbi request reprint Sporadic colorectal cancer in elderly people
    Shinichiro Koketsu
    Department of Surgical Oncology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan 113 8655
    Hepatogastroenterology 50:1749-52. 2003
    ..To investigate the carcinogenesis of colorectal cancer in elderly patients, we studied the genetic background of these patients regarding microsatellite instability and the aberrant expression of p53...
  36. ncbi request reprint Lysophosphatidic acid transactivates both c-Met and epidermal growth factor receptor, and induces cyclooxygenase-2 expression in human colon cancer LoVo cells
    Dai Shida
    Department of Surgical Oncology, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Japan
    World J Gastroenterol 11:5638-43. 2005
    ....
  37. ncbi request reprint Invasive micropapillary carcinoma of the ascending colon--a report of a case
    Hajime Shibuya
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Int Surg 96:82-6. 2011
    ..Lymph nodes and a peritoneal nodule revealed tubular adenocarcinoma. MC is a rare disease but has high malignant potential. In the present case the tumor was small in size, but the patient had a peritoneal and multiple lung metastases...
  38. ncbi request reprint Mucinous carcinomas of the colon and rectum show higher rates of microsatellite instability and lower rates of chromosomal instability: a study matched for T classification and tumor location
    Yoshihiro Kazama
    Department of Surgical Oncology, University of Tokyo, Tokyo, Japan
    Cancer 103:2023-9. 2005
    ..The current study analyzed genetic and epigenetic alterations of Muc to clarify their differences from well differentiated adenocarcinomas (WD)...
  39. ncbi request reprint Reduced p16 expression correlates with lymphatic invasion in colorectal cancers
    Tomohiro Tada
    Department of Surgical Oncology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Hepatogastroenterology 50:1756-60. 2003
    ..P16, the tumor suppressor gene, plays a crucial role in the most important regulatory pathway involved in the G1/S transition, but its role in gastrointestinal neoplasia remains unclear...
  40. doi request reprint Clinical significance of circulating tumor cells, including cancer stem-like cells, in peripheral blood for recurrence and prognosis in patients with Dukes' stage B and C colorectal cancer
    Hisae Iinuma
    Department of Surgery, Teikyo University School of Medicine, 2 11 1, Kaga, Itabashi ku, Tokyo, 173 0003, Japan
    J Clin Oncol 29:1547-55. 2011
    ....
  41. doi request reprint Prediction of response to preoperative chemoradiotherapy in rectal cancer by using reverse transcriptase polymerase chain reaction analysis of four genes
    Toshiaki Watanabe
    1Department of Surgical Oncology, The University of Tokyo, Bunkyo ku, Tokyo, Japan 2Tokushima Research Center, Taiho Pharmaceutical Co, Ltd, Harish, Kawauchi cho, Tokushima, Japan 3Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Koto ku, Tokyo, Japan 4Department of Surgery, Teikyo University School of Medicine, Itabashi ku, Tokyo, Japan
    Dis Colon Rectum 57:23-31. 2014
    ..Several gene expression signatures have been reported to predict the response to chemoradiotherapy in rectal cancer, but the lack of practical assays has restricted the clinical use of this technique...
  42. ncbi request reprint Early-outgrowth of endothelial progenitor cells can function as antigen-presenting cells
    Masahiro Asakage
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Tokyo 113 0033, Japan
    Cancer Immunol Immunother 55:708-16. 2006
    ..In conclusion, EO-EPCs should be an interesting alternative for the development of new therapeutic strategies to combat cancer, either as the effectors or as the targets of cancer immunotherapy...
  43. pmc Prognostic significance of CTCs and CSCs of tumor drainage vein blood in Dukes' stage B and C colorectal cancer patients
    Ryu Shimada
    Department of Surgery, Teikyo University School of Medicine, Tokyo 173 0003, Japan
    Oncol Rep 27:947-53. 2012
    ..These results suggest that detecting CEA/CK/CD133 mRNA in tumor drainage blood by the real-time RT-PCR method would have a prognostic value in CRC patients with Dukes' stage B and C...
  44. ncbi request reprint Skin metastasis from sigmoid colon cancer
    Atsushi Horiuchi
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Int Surg 96:135-8. 2011
    ..Around the same time, a raised lesion that appeared on the scalp was diagnosed as skin metastasis and treated with best supportive care. Thereafter, the brain metastases continued to spread, and the patient died in October 2008...
  45. doi request reprint A phase 2 trial of intravenous and intraperitoneal paclitaxel combined with S-1 for treatment of gastric cancer with macroscopic peritoneal metastasis
    Hironori Yamaguchi
    Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    Cancer 119:3354-8. 2013
    ..This phase 2 study evaluated the benefits and tolerability of weekly intravenous and intraperitoneal paclitaxel (PTX) treatment combined with oral S-1 in patients with gastric cancer who had macroscopic peritoneal metastasis...
  46. ncbi request reprint K-ras mutation and loss of heterozygosity at 17p with beta-catenin accumulation in intramucosal carcinoma of the ileostomy in familial adenomatous polyposis: a case report
    Keisuke Hata
    Department of Surgical Oncology, University of Tokyo, Tokyo, Japan
    Dig Dis Sci 48:2310-4. 2003
  47. ncbi request reprint Selective inhibition of cyclooxygenase (COX)-2 inhibits endothelial cell proliferation by induction of cell cycle arrest
    Kentaro Yazawa
    Department of Surgical Oncology, Faculty of Medical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Cancer 113:541-8. 2005
    ..The inhibitory effect on EC proliferation was dependent on the cell cycle arrest to the G1 phase and not on cell apoptosis...
  48. doi request reprint Hepatic steatosis is associated with lower incidence of liver metastasis from colorectal cancer
    Koji Murono
    Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Colorectal Dis 28:1065-72. 2013
    ..The liver is the most frequent site of distant metastasis of CRC; however, the impact of HS on the incidence of liver metastasis of CRC is not clearly defined. Then, the correlation with the presence or absence of HS was analyzed...
  49. ncbi request reprint Vaccination with autologous endothelium inhibits angiogenesis and metastasis of colon cancer through autoimmunity
    Yurai Okaji
    Department of Surgical Oncology, Graduate School of Medical Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Cancer Sci 95:85-90. 2004
    ..Our results suggest that vaccination with autologous endothelium can overcome peripheral tolerance of self-angiogenic antigens and therefore should be useful for adjuvant immunotherapy of cancer...
  50. ncbi request reprint Erythrocytes, as well as microbubble contrast agents, are important factors in improving thermal and therapeutic effects of high-intensity focused ultrasound
    Kenji Takegami
    Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    Ultrasound Med Biol 31:385-90. 2005
    ..01). The mean volume of coagulation necrosis was significantly greater in the rabbits with higher hematocrits (p<0.01), and that in the moderate anemia group was significantly increased by using Levovist (p<0.01)...
  51. ncbi request reprint A case of appendiceal Crohn's disease in which a laparoscopic appendectomy was performed
    Tamuro Hayama
    Department of Surgery, Teikyo University School of Medicine, Kaga, Itabashi ku, Tokyo, Japan
    Int Surg 95:338-42. 2010
    ..The postoperative course was uneventful, and the patient was discharged from the hospital 3 days after surgery. No sign of recurrence has been observed up to now, 6 months after surgical treatment...
  52. ncbi request reprint Prognostic significance of Ku70 protein expression in patients with advanced colorectal cancer
    Yasuhiro Komuro
    Department of Surgical Oncology, Faculty of Medicine, University of Tokyo, Japan
    Hepatogastroenterology 52:995-8. 2005
    ..However, in colorectal carcinoma, the clinical significance of Ku70 expression remains unclear. We examined the expression pattern of Ku70 in sporadic colorectal cancer and its relation to clinicopathological parameters and survival...
  53. doi request reprint Predictive value of cancer stem-like cells and cancer-associated genetic markers for peritoneal recurrence of colorectal cancer in patients after curative surgery
    Keisuke Nakamura
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Oncology 78:309-15. 2010
    ..In this study, we examined the prognostic value of free cancer cells in peritoneal washings from CRC patients after curative resection using multiple molecular markers, including cancer stem-like cells...
  54. ncbi request reprint Silencing of secreted frizzled-related protein genes in MSI colorectal carcinogenesis
    Junichiro Tanaka
    Department of Surgical Oncology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Hepatogastroenterology 55:1265-8. 2008
    ..It has also been reported that microsatellite unstable cancers show more frequent hypermethylation in tumor suppressor genes and less frequent APC mutation...
  55. ncbi request reprint Aberrant expression of lysophosphatidic acid (LPA) receptors in human colorectal cancer
    Dai Shida
    Department of Surgical Oncology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Lab Invest 84:1352-62. 2004
    ..These results suggested that alteration of LPA receptor expression might be an important event in the development of colorectal cancer, and therefore, LPA and its receptors could be a chemopreventive target against colorectal cancer...
  56. ncbi request reprint Targeting Id1 and Id3 inhibits peritoneal metastasis of gastric cancer
    Takeshi Tsuchiya
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Japan
    Cancer Sci 96:784-90. 2005
    ..Id should be considered an ideal target for the treatment and prevention of gastric cancer, and RNA interference is an attractive and promising strategy to achieve it...
  57. ncbi request reprint Anti-angiogenic properties of plaunotol
    Kazushige Kawai
    Department of Surgical Oncology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Anticancer Drugs 16:401-7. 2005
    ..The alphavbeta3 antagonists are known to be potent inhibitors of tumor angiogenesis and plaunotol, by causing the functional inhibition of alphavbeta3, should be considered a promising new anti-angiogenic drug...
  58. doi request reprint Clinicopathological and prognostic value of microRNA-21 and microRNA-155 in colorectal cancer
    Hajime Shibuya
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Oncology 79:313-20. 2010
    ..In this study, we established the prognostic value of miR-21 and miR-155 using clinical samples from CRC patients. Furthermore, relationships between these microRNAs and target genes (PDCD4 and TP53INP1 mRNAs) were examined...
  59. doi request reprint Multimedia article. Lateral lymph node dissection with preoperative chemoradiation for locally advanced lower rectal cancer through a laparoscopic approach
    Tsuyoshi Konishi
    Department of Gastroenterological Surgery, Cancer Institute Hospital, and Department of Surgery, Teikyo University School of Medicine, 3 8 31 Ariake, Koto ku, Tokyo, 135 8550, Japan
    Surg Endosc 25:2358-9. 2011
    ....
  60. ncbi request reprint Expression pattern of telomerase reverse transcriptase in rectal carcinoma predicts tumor radiosensitivity, local recurrence and disease-free survival
    Yasuhiro Komuro
    Department of Surgical Oncology, Faculty of Medicine, University of Tokyo, Japan
    Hepatogastroenterology 52:985-9. 2005
    ....
  61. ncbi request reprint Evaluating the combination of molecular prognostic factors in tumor radiosensitivity in rectal cancer
    Yasuhiro Komuro
    Department of Surgical Oncology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Hepatogastroenterology 52:666-71. 2005
    ..We investigated whether the combination of Ku, p53, p21, and p16 predicted tumor radiosensitivity...
  62. ncbi request reprint Temsirolimus and chloroquine cooperatively exhibit a potent antitumor effect against colorectal cancer cells
    Manabu Kaneko
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Cancer Res Clin Oncol 140:769-81. 2014
    ....
  63. ncbi request reprint Poorly differentiated colorectal adenocarcinomas show higher rates of microsatellite instability and promoter methylation of p16 and hMLH1: a study matched for T classification and tumor location
    Yoshihiro Kazama
    Department of Surgical Oncology, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Surg Oncol 97:278-83. 2008
    ..Extensive genetic and epigenetic analysis of poorly differentiated colorectal adenocarcinomas (Por) has been difficult, as the number of cases is too small...
  64. ncbi request reprint Chemoradiotherapy for rectal cancer: current status and perspectives
    Toshiaki Watanabe
    Department of Surgery, University of Tokyo Hospital, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Int J Clin Oncol 9:475-83. 2004
  65. ncbi request reprint Epigallocatechin gallate attenuates adhesion and migration of CD8+ T cells by binding to CD11b
    Kazushige Kawai
    Department of Surgical Oncology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Allergy Clin Immunol 113:1211-7. 2004
    ..Although green tea polyphenol catechin has been reported to have antiallergic and anti-inflammatory activities, the precise mechanisms of its effect on the immune system have been poorly investigated...
  66. ncbi request reprint hRFI overexpressed in HCT116 cells modulates Bcl-2 family proteins when treated with 5-fluorouracil
    Shin Sasaki
    Department of Surgical Oncology, The University of Tokyo, Hongo, Tokyo 113 8655, Japan
    Oncol Rep 15:1293-8. 2006
    ..Such evidence suggests that the modulation of Bcl-2 family proteins seen in 5-FU treatment plays an important role in the anti-apoptotic function of HCT116/hRFI cells...
  67. ncbi request reprint Epigallocatechin gallate induces apoptosis of monocytes
    Kazushige Kawai
    Department of Surgical Oncology, Faculty of Medicine, University of Tokyo, Japan
    J Allergy Clin Immunol 115:186-91. 2005
    ..Green tea polyphenol catechin has been reported to have antiallergic and anti-inflammatory activities, but its effect on monocytes has not yet been explored...
  68. ncbi request reprint Mucinous colorectal cancers with chromosomal instability: a biologically distinct and aggressive subtype
    Yoshihiro Kazama
    Department of Surgical Oncology, University of Tokyo, Tokyo, Japan
    Diagn Mol Pathol 15:30-4. 2006
    ..10). CSI-MCRC correlates more strongly with lymph node metastasis and advanced stage than MSI-MCRC. This indicates that CSI-MCRC is an aggressive subtype...
  69. ncbi request reprint Sphingosine 1-phosphate transactivates c-Met as well as epidermal growth factor receptor (EGFR) in human gastric cancer cells
    Dai Shida
    Department of Surgical Oncology, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    FEBS Lett 577:333-8. 2004
    ..Our results indicate that S1P acts upstream of various RTKs and thus may act as a potent stimulator of gastric cancer...
  70. ncbi request reprint A case of lung squamous cell carcinoma with metastases to the duodenum and small intestine
    Hideki Yamada
    Department of Surgery, Teikyo University School of Medicine, Itabashiku, Tokyo, Japan
    Int Surg 96:176-81. 2011
    ..Small intestine metastasis of lung cancer was diagnosed following histopathologic examination. When lung cancer patients complain of abdominal symptoms, it is important to consider gastrointestinal metastases in diagnosis and treatment...
  71. ncbi request reprint Tumor budding and evidence-based treatment of T2 rectal carcinomas
    Tadahiko Masaki
    Department of Surgery, Kyorin University, 6 20 2, Shinkawa, Mitaka City, Tokyo, Japan
    J Surg Oncol 92:59-63. 2005
    ..The validity of the histological criteria in deciding additional bowel resection after local excision of T2 rectal carcinomas is questioned...
  72. ncbi request reprint What types of colorectal cancer overexpress the MAGE protein?
    Shin ichiro Koketsu
    Department of Surgical Oncology, Graduate School of Medicine, University of Tokyo, Japan
    Hepatogastroenterology 51:1648-52. 2004
    ..Tumor-specific antigens such as Melanoma-associated antigens could be attractive targets for immunotherapy. It will be a great help for cancer immunotherapy to distinguish what types of tumor expresses tumor-specific antigen...
  73. ncbi request reprint Cytomegalovirus infection in ulcerative colitis
    Tetsu Kojima
    Department of Surgical Oncology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Scand J Gastroenterol 41:706-11. 2006
    ..The aim of this study was to investigate the clinicopathologic features of CMV infection in UC patients who had undergone colectomy...
  74. ncbi request reprint Diffuse expression of hRFI is correlated with blood vessel invasion in gastric carcinoma
    Shin Sasaki
    Department of Surgical Oncology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Jpn J Clin Oncol 34:584-7. 2004
    ..Furthermore, its diffuse expression is associated with colorectal carcinogenesis. However, hRFI expression in gastric carcinomas has not been evaluated so far...
  75. doi request reprint Prognostic significance of adverse events associated with preoperative radiotherapy for rectal cancer
    Soichiro Ishihara
    Department of Surgery, Teikyo University, 2 11 1, Kaga, Itabashi ku, Tokyo, 173 8605, Japan
    Int J Colorectal Dis 26:911-7. 2011
    ..The aim of this study is to clarify the clinical and pathological features of the patients with PRT-related adverse events, and the significance of the adverse events on the clinical outcome...
  76. pmc Microsatellite instability in poorly differentiated adenocarcinomas of the colon and rectum: relationship to clinicopathological features
    Yoshihiro Kazama
    Department of Surgical Oncology, University of Tokyo, Tokyo, Japan
    J Clin Pathol 60:701-4. 2007
    ..Por is highly associated with microsatellite instability (MSI), although MSI is associated with an improved prognosis in colorectal cancers...
  77. ncbi request reprint Telomerase subunit immunoreactivity and recurrence in colorectal cancer
    Tatsuya Ohnishi
    Department of Surgical Oncology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Hepatogastroenterology 53:188-91. 2006
    ..In this study we attempted to show by means of immunohistochemistry the association between hTERT expression and recurrence in 128 colorectal cancer patients surgically treated in the University of Tokyo Hospital...
  78. ncbi request reprint Exogenous expression of hRFI induces multidrug resistance through escape from apoptosis in colorectal cancer cells
    Tsuyoshi Konishi
    Department of Surgical Oncology, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Anticancer Res 25:2737-41. 2005
    ..The aim of this study was to determine whether hRFI possesses an anti-apoptotic function in colorectal cancer cells against chemotherapeutic agents...
  79. ncbi request reprint Lysophospholipids transactivate HER2/neu (erbB-2) in human gastric cancer cells
    Dai Shida
    Department of Surgical Oncology, University of Tokyo Graduate School of Medicine, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 327:907-14. 2005
    ..Our results indicate that LPA and S1P act upstream of HER2 in gastric cancer cells, and thus may act as potent stimulators of gastric cancer...
  80. ncbi request reprint Effect of cystathionine beta-synthase variant 844ins68bp and methylenetetrahydrofolate reductase A1298C polymorphisms in xenografts on 5-FU efficacy and doubling time
    Shin Sasaki
    Department of Surgical Oncology, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Cancer Lett 241:256-62. 2006
    ..0008). Twenty-nine cellular proliferation-related genes were associated with MTHFR-A1298C genotyping and with the doubling time...
  81. ncbi request reprint Transactivation of epidermal growth factor receptor is involved in leptin-induced activation of janus-activated kinase 2 and extracellular signal-regulated kinase 1/2 in human gastric cancer cells
    Dai Shida
    Department of Surgical Oncology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Cancer Res 65:9159-63. 2005
    ..Our results reveal that EGFR transactivation is involved in the leptin signaling pathway in gastric cancer cells, which extends the physiologic action of leptin beyond its central effects in the hypothalamus to regulate body weight...
  82. ncbi request reprint Confined progression of cap polyposis along the anastomotic line, implicating the role of inflammatory responses in the pathogenesis
    Tsuyoshi Konishi
    Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, Japan
    Gastrointest Endosc 62:446-7; discussion 447. 2005
  83. ncbi request reprint Left-Sided microsatellite unstable colorectal cancers show less frequent methylation of hMLH1 and CpG island methylator phenotype than right-sided ones
    Junichiro Tanaka
    Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan
    J Surg Oncol 96:611-8. 2007
    ..To the best of our knowledge, this is the first to report that left-sided CRCs show significantly less frequent methylation at several loci and CpG island methylator phenotype (CIMP) than right-sided ones...
  84. ncbi request reprint Dual mode regulation of migration by lysophosphatidic acid in human gastric cancer cells
    Dai Shida
    Department of Surgical Oncology, University of Tokyo Graduate School of Medicine, Tokyo 113 8655, Japan
    Exp Cell Res 301:168-78. 2004
    ..Our results indicate that LPA regulates the migration of gastric cancer cells in a receptor-specific manner and suggest that the expression pattern of LPA receptors may affect the metastatic behavior of gastric cancer...
  85. ncbi request reprint Expression pattern of vascular endothelial growth factor-C in human colorectal normal mucosa and neoplastic mucosa
    Shinsuke Kazama
    Division of Surgical Oncology, Department of Surgery, Faculty of Medicine University of Tokyo, Tokyo, Japan
    Hepatogastroenterology 51:391-5. 2004
    ..Vascular endothelial growth factor-C (VEGF-C) is a potent growth factor stimulating lymphangiogenesis...
  86. ncbi request reprint Changes to the dihydropyrimidine dehydrogenase gene copy number influence the susceptibility of cancers to 5-FU-based drugs: Data mining of the NCI-DTP data sets and validation with human tumour xenografts
    Takashi Kobunai
    Department of Systematic Clinical Oncology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Eur J Cancer 43:791-8. 2007
    ..002). Moreover, DPD mRNA expression levels were significantly correlated with DPD copy numbers (P<0.046). An assessment of copy number may be a more precise method of predicting the sensitivity of cancer patients to 5-FU related drugs...
  87. pmc Prognosis and risk factors of metastasis in colorectal carcinoids: results of a nationwide registry over 15 years
    Tsuyoshi Konishi
    Department of Surgical Oncology, University of Tokyo, Tokyo, Japan
    Gut 56:863-8. 2007
    ..In addition, no global consensus has been established on the crucial determinants of metastasis in colorectal carcinoids...
  88. ncbi request reprint Effect of herb lignin on the growth of enterobacteria
    Kazuko Toh
    National Institute of Advanced Industrial Science and Technology, Nagoya, Aichi, Japan
    J Gen Appl Microbiol 53:201-5. 2007
  89. doi request reprint The frequency of KRAS mutation detection in human colon carcinoma is influenced by the sensitivity of assay methodology: a comparison between direct sequencing and real-time PCR
    Takashi Kobunai
    Department of Surgery, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, Tokyo 173 8605, Japan
    Biochem Biophys Res Commun 395:158-62. 2010
    ..The purpose of this study was to evaluate the influence of assay sensitivity on the detection frequency of mutated genes...
  90. ncbi request reprint Synchronous spontaneous arteriovenous fistula and aneurysm of the deep femoral artery incidentally found in a patient with aortic aneurysmal dissection
    Shinichi Nakamura
    Department of Radiology, Kumamoto Red Cross Hospital, 2 1 1 Nagamineminami, Kumamoto, 862 8520, Japan
    Radiat Med 26:427-30. 2008
    ..After vascular repair of the aneurysm and the AVF of the right DFA, there was no sign of recurrence...
  91. ncbi request reprint [Mutation of EGFR signaling pathway and therapy for metastatic colorectal cancer]
    Keijirou Nozawa
    Dept of Surgery, Teikyo University, Itabashi ku, Tokyo, Japan
    Gan To Kagaku Ryoho 37:791-4. 2010
    ..A topping the offered figure effect of cetuximab is not accepted. The addition of cetuximab for treatment of metastatic colorectal cancer with Kras wild-type tumors is effective...
  92. ncbi request reprint Poorly differentiated adenocarcinoma and mucinous carcinoma of the colon and rectum show higher rates of loss of heterozygosity and loss of E-cadherin expression due to methylation of promoter region
    Takamitsu Kanazawa
    Department of Surgical Oncology, Graduate School of Medical Sciences, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Int J Cancer 102:225-9. 2002
    ..047). These results suggest that the higher rates of LOH contribute to Por & Muc tumourigenesis and most of Por & Muc lose normal E-cadherin expression, partly because of the methylation of promoter region...
  93. ncbi request reprint Extended lymphadenectomy and preoperative radiotherapy for lower rectal cancers
    Toshiaki Watanabe
    Department of Surgery, University of Tokyo Hospital, The Cancer Institute Hospital, Japan
    Surgery 132:27-33. 2002
    ..However, EXT-L is frequently associated with impairment of sexual and urinary function. We therefore compared the effectiveness of preoperative radiotherapy with that of EXT-L...
  94. ncbi request reprint Rapid genetic diagnosis with transcription-reverse transcription concerted reaction system for peritoneal recurrence and survival in colorectal cancer patients
    Tamuro Hayama
    Department of Surgery, Teikyo University School of Medicine, Tokyo 173 0003, Japan
    Oncol Rep 18:779-84. 2007
    ..In conclusion, our study demonstrated that the detection of CEA mRNA in peritoneal washings by TRC is a useful, rapid genetic diagnosis for the prediction of peritoneal recurrence and survival in patients with colorectal cancer...
  95. ncbi request reprint FDG-PET after radiotherapy is a good prognostic indicator of rectal cancer
    Shinya Oku
    Department of Radiology, University of Tokyo Hospital, Japan
    Ann Nucl Med 16:409-16. 2002
    ....
  96. ncbi request reprint Detection of cancer cells in mesenteric vein and peripheral vessels by measuring telomerase activity in patients with colorectal cancer
    Hiroaki Nozawa
    Department of Surgical Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Surgery 134:791-8. 2003
    ..The objective of this study was to assess whether colorectal cancer cells in the drainage veins can be detected by measuring telomerase activity and its detection is correlated with liver metastasis...
  97. ncbi request reprint [Different strategies between Japan and other countries for the diagnosis and treatment of rectal cancer]
    Toshiaki Watanabe
    Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    Nihon Geka Gakkai Zasshi 109:338-42. 2008
    ..However, this is a very important issue in determining the postoperative adjuvant chemotherapy. In Japan, these differences need to be taken into account in determining the postoperative adjuvant chemotherapy regimen...
  98. ncbi request reprint Cerebral lipiodol embolism after transcatheter arterial chemoembolization of hepatocellular carcinoma
    Hidemasa Takao
    Department of Radiology, Showa General Hospital, Tokyo, Japan
    J Comput Assist Tomogr 29:680-2. 2005
    ..Magnetic resonance imaging showed restricted diffusion within the thalami and basal ganglia. The patient's level of consciousness gradually improved, and all neurologic symptoms disappeared over 6 weeks...
  99. ncbi request reprint Vascular endothelial growth factor-C (VEGF-C) is a more specific risk factor for lymph node metastasis than VEGF-D in submucosal colorectal cancer
    Shinsuke Kazama
    Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Hepatogastroenterology 54:71-6. 2007
    ..Whether vascular endothelial growth factor-C (VEGF-C) or VEGF-D could predict lymph node metastasis and lymphatic involvement is uncertain...
  100. ncbi request reprint Colon cancer complicated by vascular and intestinal anomaly
    Hiroaki Uchida
    Division of Surgical Oncology, Department of Surgery, The University of Tokyo, Tokyo, Japan
    Hepatogastroenterology 51:156-8. 2004
    ..Selective angiography and preoperative endoscopic submucosal injection of India ink near the tumor were thought to be essential for surgical decision-making...
  101. ncbi request reprint Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1
    Dai Shida
    Department of Surgical Oncology, University of Tokyo Graduate School of Medicine, Tokyo 113 8655, Japan
    Cancer Res 63:1706-11. 2003
    ..Our results suggest that LPA acts as a potent stimulator of colon cancer progression, although the binding to LPA1 and LPA2 induces slightly different responses...