Hitoshi Takahashi

Summary

Affiliation: Graduate School
Country: Japan

Publications

  1. ncbi request reprint Switching to risperidone after unsuccessful treatment of olanzapine in the first-episode schizophrenia: an open trial
    Hitoshi Takahashi
    Yuri Kumiai General Hospital, 38 Yago, Honjo shi, Akita, 015 8511, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1067-72. 2006
  2. ncbi request reprint Switching to olanzapine after unsuccessful treatment with risperidone during the first episode of schizophrenia: an open-label trial
    Hitoshi Takahashi
    Yuri Kumiai General Hospital, Honjoh, Akita, Japan
    J Clin Psychiatry 67:1577-82. 2006
  3. doi request reprint Efficacy and tolerability of aripiprazole in first-episode drug-naive patients with schizophrenia: an open-label trial
    Hitoshi Takahashi
    Department of Psychiatry, Tokyo Women s Medical University, Tokyo, Japan
    Clin Neuropharmacol 32:149-50. 2009
  4. ncbi request reprint Influence of the tyrosine hydroxylase val81met polymorphism and catechol-O-methyltransferase val158met polymorphism on the antidepressant effect of milnacipran
    Keizo Yoshida
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Hum Psychopharmacol 23:121-8. 2008
  5. ncbi request reprint Monoamine oxidase A gene polymorphism, 5-HT 2A receptor gene polymorphism and incidence of nausea induced by fluvoxamine
    Keizo Yoshida
    Department of Psychiatry, Akita University School of Medicine, Akita, Japan
    Neuropsychobiology 48:10-3. 2003
  6. ncbi request reprint No association between the serotonergic polymorphisms and incidence of nausea induced by fluvoxamine treatment
    Hitoshi Takahashi
    Department of Psychiatry, Akita University School of Medicine, 1 1 1, Hondo, 010 8543, Akita, Japan
    Eur Neuropsychopharmacol 12:477-81. 2002
  7. ncbi request reprint Association between -1438G/A promoter polymorphism in the 5-HT(2A) receptor gene and fluvoxamine response in Japanese patients with major depressive disorder
    Kazuhiro Sato
    Department of Psychiatry, Akita University School of Medicine, Akita, Japan
    Neuropsychobiology 46:136-40. 2002
  8. ncbi request reprint Degeneration of cardiac sympathetic nerve begins in the early disease process of Parkinson's disease
    Satoshi Orimo
    Department of Neurology, Kanto Central Hospital, Tokyo, Japan
    Brain Pathol 17:24-30. 2007
  9. ncbi request reprint The G196A polymorphism of the brain-derived neurotrophic factor gene and the antidepressant effect of milnacipran and fluvoxamine
    Keizo Yoshida
    Department of Psychiatry, Nagoya University Graduate School of Medicine, 65 Tsurumail cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    J Psychopharmacol 21:650-6. 2007
  10. ncbi request reprint Monoamine oxidase: A gene polymorphism, tryptophan hydroxylase gene polymorphism and antidepressant response to fluvoxamine in Japanese patients with major depressive disorder
    Keizo Yoshida
    Department of Psychiatry, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 26:1279-83. 2002

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Switching to risperidone after unsuccessful treatment of olanzapine in the first-episode schizophrenia: an open trial
    Hitoshi Takahashi
    Yuri Kumiai General Hospital, 38 Yago, Honjo shi, Akita, 015 8511, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1067-72. 2006
    ..3%. These findings indicate that the switching to risperidone could be one of the useful treatment options in this population...
  2. ncbi request reprint Switching to olanzapine after unsuccessful treatment with risperidone during the first episode of schizophrenia: an open-label trial
    Hitoshi Takahashi
    Yuri Kumiai General Hospital, Honjoh, Akita, Japan
    J Clin Psychiatry 67:1577-82. 2006
    ..The efficacy and safety of switching to olanzapine were investigated in patients with first-episode schizophrenia who failed to attain an adequate clinical response to an initial therapeutic trial of risperidone (2-6 mg/day for 12 weeks)...
  3. doi request reprint Efficacy and tolerability of aripiprazole in first-episode drug-naive patients with schizophrenia: an open-label trial
    Hitoshi Takahashi
    Department of Psychiatry, Tokyo Women s Medical University, Tokyo, Japan
    Clin Neuropharmacol 32:149-50. 2009
    ..The purpose of this study is to investigate the safety and efficacy of aripiprazole in first-episode drug-naive patients with schizophrenia...
  4. ncbi request reprint Influence of the tyrosine hydroxylase val81met polymorphism and catechol-O-methyltransferase val158met polymorphism on the antidepressant effect of milnacipran
    Keizo Yoshida
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Hum Psychopharmacol 23:121-8. 2008
    ....
  5. ncbi request reprint Monoamine oxidase A gene polymorphism, 5-HT 2A receptor gene polymorphism and incidence of nausea induced by fluvoxamine
    Keizo Yoshida
    Department of Psychiatry, Akita University School of Medicine, Akita, Japan
    Neuropsychobiology 48:10-3. 2003
    ..If this finding is replicated in other studies with more subjects, MAOA-VNTR polymorphism would be of great clinical use to predict the incidence of nausea induced by SSRIs...
  6. ncbi request reprint No association between the serotonergic polymorphisms and incidence of nausea induced by fluvoxamine treatment
    Hitoshi Takahashi
    Department of Psychiatry, Akita University School of Medicine, 1 1 1, Hondo, 010 8543, Akita, Japan
    Eur Neuropsychopharmacol 12:477-81. 2002
    ..Results suggested that these three polymorphisms did not affect the development of fluvoxamine-induced nausea, and that incidence of nausea was not a phenomenon that predicts the treatment response to fluvoxamine...
  7. ncbi request reprint Association between -1438G/A promoter polymorphism in the 5-HT(2A) receptor gene and fluvoxamine response in Japanese patients with major depressive disorder
    Kazuhiro Sato
    Department of Psychiatry, Akita University School of Medicine, Akita, Japan
    Neuropsychobiology 46:136-40. 2002
    ..The results demonstrated that the -1438G/A promoter polymorphism in the 5-HT(2A) receptor gene was unlikely to have a major role in therapeutic response to fluvoxamine in Japanese patients with major depressive disorder...
  8. ncbi request reprint Degeneration of cardiac sympathetic nerve begins in the early disease process of Parkinson's disease
    Satoshi Orimo
    Department of Neurology, Kanto Central Hospital, Tokyo, Japan
    Brain Pathol 17:24-30. 2007
    ..These findings suggest that degeneration of the cardiac sympathetic nerve begins in the early disease process of PD and that it occurs before neuronal cell loss in the dorsal vagal nucleus...
  9. ncbi request reprint The G196A polymorphism of the brain-derived neurotrophic factor gene and the antidepressant effect of milnacipran and fluvoxamine
    Keizo Yoshida
    Department of Psychiatry, Nagoya University Graduate School of Medicine, 65 Tsurumail cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    J Psychopharmacol 21:650-6. 2007
    ..These results suggest that the BDNF G196A polymorphism in part determines the antidepressant effect of both milnacipran and fluvoxamine...
  10. ncbi request reprint Monoamine oxidase: A gene polymorphism, tryptophan hydroxylase gene polymorphism and antidepressant response to fluvoxamine in Japanese patients with major depressive disorder
    Keizo Yoshida
    Department of Psychiatry, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 26:1279-83. 2002
    ..The present study fails to demonstrate that the genetic polymorphisms of MAOA-VNTR and TPH-A218C affect the antidepressant effect of fluvoxamine in Japanese patients with major depressive disorder...
  11. ncbi request reprint Gender differences in the clinical effects of fluvoxamine and milnacipran in Japanese major depressive patients
    Shingo Naito
    Department of Psychiatry, Akita University School of Medicine, Akita, Japan
    Psychiatry Clin Neurosci 61:421-7. 2007
    ..The results suggest that fluvoxamine is more effective in younger female patients than older female patients and male patients, while milnacipran is generally effective irrespective of gender or age...
  12. doi request reprint Increased expression and activation of cytosolic phospholipase A2 in the spinal cord of patients with sporadic amyotrophic lateral sclerosis
    Noriyuki Shibata
    Department of Pathology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku 162 8666, Tokyo, Japan
    Acta Neuropathol 119:345-54. 2010
    ....
  13. ncbi request reprint Response rate obtained using milnacipran depending on the severity of depression in the treatment of major depressive patients
    Yuka Sugawara
    Department of Psychiatry, Akita University School of Medicine, Akita, Japan
    Clin Neuropharmacol 29:6-9. 2006
    ..quot; This study suggested that milnacipran has a reliable antidepressant effect in treating severe and moderate major depressive patients...
  14. doi request reprint Persistent cleavage and nuclear translocation of apoptosis-inducing factor in motor neurons in the spinal cord of sporadic amyotrophic lateral sclerosis patients
    Noriyuki Shibata
    Department of Pathology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Acta Neuropathol 118:755-62. 2009
    ..Our results provide evidence for persistent cleavage and nuclear translocation of AIF in ALS spinal cord, suggesting implications for the AIF-mediated motor neuron death in this disease...
  15. pmc Cytoplasmic location of α1A voltage-gated calcium channel C-terminal fragment (Cav2.1-CTF) aggregate is sufficient to cause cell death
    Makoto Takahashi
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Yushima, Bunkyo ku, Tokyo, Japan
    PLoS ONE 8:e50121. 2013
    ..Collectively, the cytoplasmic Cav2.1-CTF aggregates are sufficient to cause cell death, and one of the pathogenic mechanisms may be abnormal CREB trafficking in the cytoplasm and reduced CREB and p-CREB levels in the nuclei...
  16. doi request reprint Augmentation with olanzapine in TCA-refractory depression with melancholic features: a consecutive case series
    Hitoshi Takahashi
    Department of Psychiatry, Tokyo Women Medical University, Tokyo, Japan
    Hum Psychopharmacol 23:217-20. 2008
    ..We cannot draw any conclusion with certainty from the open-label, uncontrolled clinical trial. Double blind, controlled trial is needed to confirm this preliminary finding...
  17. doi request reprint Activation of signal transducer and activator of transcription-3 in the spinal cord of sporadic amyotrophic lateral sclerosis patients
    Noriyuki Shibata
    Department of Pathology, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Neurodegener Dis 6:118-26. 2009
    ..It is known that signal transducer and activator of transcription-3 (STAT3) is a proinflammatory transcription factor. However, it remains to be determined whether STAT3 is involved in ALS...
  18. ncbi request reprint Remarkable effect of milnacipran, a serotonin-noradrenalin reuptake inhibitor (SNRI), on depressive symptoms in patients with Parkinson's disease who have insufficient response to selective serotonin reuptake inhibitors (SSRIs): two case reports
    Hitoshi Takahashi
    Department of Neuropsychiatry, Akita University School of Medicine, 1 1 1, Hondo, Akita, 010 8543, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 29:351-3. 2005
    ..The case reports suggest that milnacipran may be one of the treatment options for depression in patients with Parkinson's disease who had inadequate response to SSRIs. Further studies are warranted to confirm this observation...
  19. ncbi request reprint Addition of a dopamine agonist, cabergoline, to a serotonin-noradrenalin reuptake inhibitor, milnacipran as a therapeutic option in the treatment of refractory depression: two case reports
    Hitoshi Takahashi
    Department of Neuro Psychiatry, Akita University School of Medicine, 1 1 1 Hondo, Akita, Japan
    Clin Neuropharmacol 26:230-2. 2003
    ....
  20. doi request reprint Survival motor neuron (SMN) protein in the spinal anterior horn cells of patients with sporadic amyotrophic lateral sclerosis
    Yingshan Piao
    Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    Brain Res 1372:152-9. 2011
    ....
  21. pmc Influence of serotonergic/noradrenergic gene polymorphisms on nausea and sweating induced by milnacipran in the treatment of depression
    Hisashi Higuchi
    Department of Psychiatry, St Marianna University, School of Medicine, Kanagawa, Japan
    Neuropsychiatr Dis Treat 5:393-8. 2009
    ..Further studies with larger populations and more kinds of gene polymorphisms should be needed to see if specific gene polymorphisms determine the susceptibility of side effects induced by milnacipran...
  22. ncbi request reprint Effectiveness of milnacipran for the treatment of chronic pain: a case series
    Mitsuhiro Kamata
    Department of Psychiatry, Yuri Kumiai General Hospital, Honjo City, Japan
    Clin Neuropharmacol 27:208-10. 2004
    ..The VAS decrease for this patient was 14.3%. Results of this study show milnacipran to be beneficial in patients with chronic pain. This drug should be studied further for its effectiveness in the treatment of chronic pain...
  23. ncbi request reprint Basal ganglion hamartoma in a patient presenting with precocious puberty
    Nobuyuki Genkai
    Department of Neurosurgery, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata 951 8585, Japan
    Brain Tumor Pathol 22:45-9. 2005
    ..The possible mechanisms underlying the development of precocious puberty in this patient are discussed...
  24. ncbi request reprint Degeneration of cardiac sympathetic nerve can occur in multiple system atrophy
    Satoshi Orimo
    Department of Neurology, Kanto Central Hospital, 6 25 1 Kami Yoga, Setagaya Ku, Tokyo, 158 8531, Japan
    Acta Neuropathol 113:81-6. 2007
    ..Moreover, concurrent Lewy body pathology in the sympathetic ganglia might accelerate cardiac sympathetic denervation even in MSA...
  25. doi request reprint Glial clusters and perineuronal glial satellitosis in the basal ganglia of neurofibromatosis type 1
    Osamu Yokota
    Department of Neuropathology, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo, 156 8585, Japan
    Acta Neuropathol 116:57-66. 2008
    ..Given these findings, glial clusters and perineuronal glial satellitosis may be histopathological features of the NF1 brain and are probably associated with altered regulation of astrocyte growth in NF1...
  26. ncbi request reprint Influence of the serotonin transporter gene-linked polymorphic region on the antidepressant response to fluvoxamine in Japanese depressed patients
    Keizo Yoshida
    Department of Psychiatry, Akita University School of Medicine, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 26:383-6. 2002
    ..010). The present study suggests that fluvoxamine is not less effective in depressive patients carrying the s allele than in the ones carrying the l allele and it is not less effective in Japanese than in Caucasians...
  27. ncbi request reprint Three-repeat Tau 69 is a major tau isoform in laser-microdissected Pick bodies
    Takuya Ohkubo
    Second Department of Physiology, Tokyo Medical University, Tokyo, Japan
    Amyloid 13:1-5. 2006
    ..Such a combination of morphological and biochemical techniques significantly complements the existing histopathological methods...
  28. doi request reprint DRPLA: recent advances in research using transgenic mouse models
    Kazushi Suzuki
    Department of Neurology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Methods Mol Biol 1010:277-92. 2013
    ..Through detailed investigations of these two substrains, we believe that "neuronal dysfunction without neuronal loss" is the key concept in the pathogenesis of DRPLA...
  29. pmc Novel cell culture-adapted genotype 2a hepatitis C virus infectious clone
    Tomoko Date
    Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    J Virol 86:10805-20. 2012
    ..Interestingly, full-length viral RNA synthesized from the cDNA clone with these adaptive mutations was infectious for cultured cells. This approach may be applicable for the establishment of new infectious HCV clones...
  30. doi request reprint Reduced brain-derived neurotrophic factor (BDNF) mRNA expression and presence of BDNF-immunoreactive granules in the spinocerebellar ataxia type 6 (SCA6) cerebellum
    Makoto Takahashi
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Neuropathology 32:595-603. 2012
    ..1 aggregates in SCA6 Purkinje cells. We conclude that the SCA6 pathogenic mechanism associates with the BDNF mRNA expression reduction and abnormal localization of BDNF protein...
  31. ncbi request reprint Protein-bound crotonaldehyde accumulates in the spinal cord of superoxide dismutase-1 mutation-associated familial amyotrophic lateral sclerosis and its transgenic mouse model
    Noriyuki Shibata
    Department of Pathology, Neurological Institute, Tokyo Women s Medical University, Tokyo, Japan
    Neuropathology 27:49-61. 2007
    ....
  32. ncbi request reprint Preserved cardiac sympathetic nerve accounts for normal cardiac uptake of MIBG in PARK2
    Satoshi Orimo
    Department of Neurology, Kanto Central Hospital, Tokyo, Japan
    Mov Disord 20:1350-3. 2005
    ..Moreover, normal cardiac uptake of MIBG might be of potential diagnostic value to indicate the absence of Lewy body pathology, even in patients with levodopa-responsive Parkinsonism, as in PARK2...
  33. ncbi request reprint Effectiveness of switching to quetiapine for neuroleptic-induced amenorrhea
    Hitoshi Takahashi
    Department of Neurospsychiatry, Akita University School of Medicine, Honda, Akita City, Japan
    J Neuropsychiatry Clin Neurosci 15:375-7. 2003
    ..Findings revealed that 10 patients (71.6%) resumed menstruation, without worsening of psychotic symptoms...
  34. ncbi request reprint Fluvoxamine augmentation in risperidone-resistant schizophrenia: an open trial
    Hitoshi Takahashi
    Department of Neuropsychiatry, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Hum Psychopharmacol 17:95-8. 2002
    ..These results suggest that fluvoxamine appears to be ineffective in augmenting the risperidone treatment response in chronic schizophrenic patients. Further controlled trials will be needed to confirm this observation...
  35. ncbi request reprint [Oral cyclophosphamide therapy for multifocal fibrosclerosis with hypertrophic intracranial pachymeningitis]
    Masayoshi Tada
    Deparment of Neurology, Brain Research Institute, Niigata University
    Rinsho Shinkeigaku 46:128-33. 2006
    ..We concluded that HIP can be a manifestation of MF, and additional oral CP should be considered as a treatment for steroid-resistant MF with HIP...
  36. doi request reprint The expression of metallothioneins is diminished in the spinal cords of patients with sporadic ALS
    Isao Hozumi
    Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Gifu, Japan
    Amyotroph Lateral Scler 9:294-8. 2008
    ..MTs are defensive proteins that can scavenge free radicals; therefore, manipulation of their expression has a strong therapeutic potential for ALS patients...
  37. ncbi request reprint Effect of a combination therapy between IL-12 and soluble IL-4 receptor (sIL-4R) on Candida albicans and herpes simplex virus type I infections in thermally injured mice
    Makiko Kobayashi
    Department of Internal Medicine, The University of Texas Medical Branch, Galveston, TX 77555, USA
    Can J Microbiol 48:886-94. 2002
    ..These results suggest that therapeutic treatment with a combination of IL-12 and sIL-4R may be effective by inducing type 1 T-cell responses in thermally injured mice exposed to large amounts of HSV-1 or C. albicans...
  38. ncbi request reprint Selective reduction of a PDZ protein, SAP-97, in the prefrontal cortex of patients with chronic schizophrenia
    Kazuhiko Toyooka
    Molecular Neurobiology, Brain Research Institute, Niigata University, Japan
    J Neurochem 83:797-806. 2002
    ..In addition, neuroleptic treatment failed to mimic the SAP97 change. These findings suggest that a phenotypic loss of SAP97 is associated with the postsynaptic impairment in prefrontal excitatory circuits of schizophrenic patients...
  39. ncbi request reprint Corticobasal degeneration with focal, massive tau accumulation in the subcortical white matter astrocytes
    Kenji Sakai
    Department of Pathology, Brain Research Institute, University of Niigata, 1 757 Asahimachi, Niigata 951 8585, Japan
    Acta Neuropathol 112:341-8. 2006
    ..Finally, in both cases, the pathological diagnosis of CBD was considered to be appropriate. However, the tau pathology affecting the subcortical white matter astrocytes was very unusual for the disease...
  40. ncbi request reprint Cerebellar cortical tau pathology in progressive supranuclear palsy and corticobasal degeneration
    Yue Shan Piao
    Department of Pathology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata 951 8585, Japan
    Acta Neuropathol 103:469-74. 2002
    ..In conclusion, we have demonstrated a novel tau pathology that affects Purkinje cells and Bergmann's glia in patients with PSP and CBD, indicating that the cerebellar cortex can be involved in the disease processes in PSP and CBD...
  41. ncbi request reprint Tardive dystonia and genetic polymorphisms of cytochrome P4502D6 and dopamine D2 and D3 receptors: a preliminary finding
    Kazuo Mihara
    Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, Japan
    Am J Med Genet 114:693-5. 2002
    ..No specific genotypes or alleles were overpresented in the patients. This study suggests that these polymorphisms are not related to the development of tardive dystonia...
  42. ncbi request reprint Demonstration of alpha-synuclein immunoreactivity in neuronal and glial cytoplasm in normal human brain tissue using proteinase K and formic acid pretreatment
    Fumiaki Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Japan
    Exp Neurol 176:98-104. 2002
    ..These findings suggest that a significant amount of alphaS is also present in the neuronal and glial cytoplasm in the normal human brain...
  43. ncbi request reprint Pathologic features of dysplasia and accompanying alterations observed in surgical specimens from patients with intractable epilepsy
    Akiyoshi Kakita
    Department of Pathological Neuroscience, Brain Research Institute, University of Niigata, Japan
    J Child Neurol 20:341-50. 2005
    ..Astrocytes might also actively participate in the development of the pathogenesis of epilepsy...
  44. ncbi request reprint Some glial progenitors in the neonatal subventricular zone migrate through the corpus callosum to the contralateral cerebral hemisphere
    Akiyoshi Kakita
    Department of Pathology, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    J Comp Neurol 458:381-8. 2003
    ..Thus, glial progenitors migrate across the CC, presumably in conjunction with unmyelinated axons, to colonize the contralateral hemisphere...
  45. doi request reprint Sporadic amyotrophic lateral sclerosis: two pathological patterns shown by analysis of distribution of TDP-43-immunoreactive neuronal and glial cytoplasmic inclusions
    Yasushi Nishihira
    Department of Pathology, Brain Research Institute, University of Niigata, 1 757 Asahimachi, Chuo Ku, Niigata, 951 8585, Japan
    Acta Neuropathol 116:169-82. 2008
    ....
  46. ncbi request reprint Relationship between clinical effects of fluvoxamine and the steady-state plasma concentrations of fluvoxamine and its major metabolite fluvoxamino acid in Japanese depressed patients
    Gisa Gerstenberg
    Department of Neuropsychiatry, Yamagata University School of Medicine, 990 9585 Yamagata, Japan
    Psychopharmacology (Berl) 167:443-8. 2003
    ..The relationship between clinical effects of fluvoxamine (FLV) and the steady-state plasma concentrations (Css) of FLV and its major metabolite fluvoxamino acid (FLA) was studied...
  47. ncbi request reprint Pathological heterogeneity in progressive supranuclear palsy and corticobasal degeneration
    Koichi Wakabayashi
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Neuropathology 24:79-86. 2004
    ..Moreover, several neurodegenerative disorders can underlie CBD. This pathological heterogeneity leads to difficulty in the clinical and pathological diagnosis of both disorders...
  48. ncbi request reprint Effect of quetiapine in the treatment of panic attacks in patients with schizophrenia: 3 case reports
    Hitoshi Takahashi
    Department of Neuropsychiatry, Akita University School of Medicine, Japan
    J Neuropsychiatry Clin Neurosci 16:113-5. 2004
    ....
  49. ncbi request reprint Prefrontal abnormality of schizophrenia revealed by DNA microarray: impact on glial and neurotrophic gene expression
    Tetsuji Sugai
    Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
    Ann N Y Acad Sci 1025:84-91. 2004
    ..The present profiling study suggests a potential biological link between abnormal neurotrophic signals and impaired glial functions in schizophrenic pathology...
  50. ncbi request reprint TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation
    Chun Feng Tan
    Department of Pathology, Brain Research Institute, University of Niigata, 1 757 Asahimachi, Niigata 951 8585, Japan
    Acta Neuropathol 113:535-42. 2007
    ..These findings indicate that the histological and molecular pathology of SALS can occur as a phenotype of FALS without SOD1 mutation...
  51. ncbi request reprint Reciprocal accumulation of beta-synuclein in alpha-synuclein lesions in multiple system atrophy
    Fumiaki Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Neuroreport 14:1783-6. 2003
    ..Thus, neuronal alpha-synuclein inclusions appear to occur only rarely in neurons in which beta-synuclein accumulates. These findings support the possibility that beta-synuclein is a negative regulator of alpha-synuclein aggregation...
  52. ncbi request reprint Disruption of postnatal progenitor migration and consequent abnormal pattern of glial distribution in the cerebrum following administration of methylmercury
    Akiyoshi Kakita
    Department of Pathological Neuroscience, Resource Branch for Brain Disease Research CBBR, Brain Research Institute, Niigata University, Asahimachi, Niigata, Japan
    J Neuropathol Exp Neurol 62:835-47. 2003
    ..Thus, exposure to MeHg in the gliogenic period induced irregular distribution of glia as a consequence of abnormal migration of the postnatal progenitors...
  53. ncbi request reprint TDP-43-immunoreactive neuronal and glial inclusions in the neostriatum in amyotrophic lateral sclerosis with and without dementia
    Haixin Zhang
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562, Japan
    Acta Neuropathol 115:115-22. 2008
    ..These findings suggest that the neostriatum is also involved in the disease process of ALS with and without dementia...
  54. ncbi request reprint No association of the G1287A polymorphism in the norepinephrine transporter gene and susceptibility to major depressive disorder in a Japanese population
    Kazuyuki Inoue
    Department of Pharmaceutical Science, Akita University Hospital, Japan
    Biol Pharm Bull 30:1996-8. 2007
    ..NET G1287A polymorphism appears not to be an important factor in susceptibility to MDD in a Japanese population...
  55. ncbi request reprint Cellular pathology in multiple system atrophy
    Koichi Wakabayashi
    Department of Neuropathology, Institute of Brain Science, School of Medicine, Hirosaki University, Japan
    Neuropathology 26:338-45. 2006
    ..These two degenerative processes might synergistically cause neuronal depletion in MSA...
  56. ncbi request reprint A decrease in interleukin-1 receptor antagonist expression in the prefrontal cortex of schizophrenic patients
    Kazuhiko Toyooka
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi dori 1 757, 951 8585, Niigata, Japan
    Neurosci Res 46:299-307. 2003
    ..IL-1RA reduction might reflect an immunopathologic trait of the prefrontal region in schizophrenic patients...
  57. ncbi request reprint Prediction of antidepressant response to milnacipran by norepinephrine transporter gene polymorphisms
    Keizo Yoshida
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, USA
    Am J Psychiatry 161:1575-80. 2004
    ....