Tomomitsu Tahara

Summary

Affiliation: Graduate School
Country: Japan

Publications

  1. pmc A Genetic Variant of the CD14 C-159T in Patients with Functional Dyspepsia (FD) in Japanese Subjects
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    J Clin Biochem Nutr 42:104-10. 2008
  2. pmc The Role of RANTES Promoter Polymorphism in Functional Dyspepsia
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    J Clin Biochem Nutr 45:235-40. 2009
  3. pmc Genetic Polymorphisms of Molecules Associated with Innate Immune Responses, TRL2 and MBL2 Genes in Japanese Subjects with Functional Dyspepsia
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    J Clin Biochem Nutr 47:217-23. 2010
  4. pmc Analysis of Beta-Tubulin Gene Exon 4 Mutations in Advanced Stage III or IV Gastric Cancer
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    J Clin Biochem Nutr 40:210-5. 2007
  5. pmc Absence of Common Polymorphisms of Toll Like Receptor 4 (TLR4): Asp299Gly, Thr399Ile in Patients with Gastroduodenal Diseases in Japan
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    J Clin Biochem Nutr 40:62-5. 2007
  6. pmc Influence of IL17A polymorphisms on the aberrant methylation of DAPK and CDH1 in non-cancerous gastric mucosa
    Tomiyasu Arisawa
    Department of Gastroenterology, Kanazawa Medical University, Daigaku, Uchinada machi, Ishikawa, Japan
    BMC Med Genet 13:59. 2012
  7. pmc Influence of HRH2 promoter polymorphism on aberrant DNA methylation of DAPK and CDH1 in the gastric epithelium
    Tomoe Nomura
    Department of Gastroenterology, Kanazawa Medical University, 1 1, Daigaku, Uchinada machi, Ishikawa, 920 0293, Japan
    BMC Gastroenterol 13:1. 2013
  8. doi request reprint Role of heat-shock protein (HSP) 70-2 genotype in peptic ulcer in Japanese population
    Tomomitsu Tahara
    Department of Gastoenterology, Fujita Health University School of Medicine, Aichi, Japan
    Hepatogastroenterology 59:426-9. 2012
  9. doi request reprint Synergistic effect of IL-1β and TNF-α polymorphisms on the H. pylori-related gastric pre-malignant condition
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Japan
    Hepatogastroenterology 59:2416-20. 2012
  10. doi request reprint Examination of serum pepsinogen in functional dyspepsia
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyake, Japan
    Hepatogastroenterology 59:2516-22. 2012

Detail Information

Publications87

  1. pmc A Genetic Variant of the CD14 C-159T in Patients with Functional Dyspepsia (FD) in Japanese Subjects
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    J Clin Biochem Nutr 42:104-10. 2008
    ..The role of inflammation related-gene polymorphisms to the development of dyspepsia needs to further evaluation...
  2. pmc The Role of RANTES Promoter Polymorphism in Functional Dyspepsia
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    J Clin Biochem Nutr 45:235-40. 2009
    ..pylori positive PDS subjects (age, sex adjusted OR = 0.11, 95% CI = 0.01-0.94). Our data suggest that RANTES promoter -28G carriers is associate with a reduced risk of PDS especially in H. pylori positive subjects...
  3. pmc Genetic Polymorphisms of Molecules Associated with Innate Immune Responses, TRL2 and MBL2 Genes in Japanese Subjects with Functional Dyspepsia
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    J Clin Biochem Nutr 47:217-23. 2010
    ..22, 95% CI = 0.07-0.69, p = 0.0099). Our data suggest that TLR2 -196 to -174 del carriers's status but not MBL2 codon54 G/A is inversely related to the risk with FD in H. pylori-infected subjects...
  4. pmc Analysis of Beta-Tubulin Gene Exon 4 Mutations in Advanced Stage III or IV Gastric Cancer
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    J Clin Biochem Nutr 40:210-5. 2007
    ..In conclusion, these findings suggest that mutations of the beta-tubulin gene are rare and are unlikely to be an important cause of taxane resistance to taxians...
  5. pmc Absence of Common Polymorphisms of Toll Like Receptor 4 (TLR4): Asp299Gly, Thr399Ile in Patients with Gastroduodenal Diseases in Japan
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    J Clin Biochem Nutr 40:62-5. 2007
    ..In conclusion, our data suggest that TLR4 Asp299Gly, Thr399Ile are very rare in Japanese population and thus they may not be a important factor in determining the outcome of H. pylori infected individuals in Japan...
  6. pmc Influence of IL17A polymorphisms on the aberrant methylation of DAPK and CDH1 in non-cancerous gastric mucosa
    Tomiyasu Arisawa
    Department of Gastroenterology, Kanazawa Medical University, Daigaku, Uchinada machi, Ishikawa, Japan
    BMC Med Genet 13:59. 2012
    ..pylori colonization has been indicated. We investigated the influence of IL17A polymorphisms, -197 G > A (rs2275913) and *1249 C > T (rs3748067), on the methylation of DAPK and CDH1...
  7. pmc Influence of HRH2 promoter polymorphism on aberrant DNA methylation of DAPK and CDH1 in the gastric epithelium
    Tomoe Nomura
    Department of Gastroenterology, Kanazawa Medical University, 1 1, Daigaku, Uchinada machi, Ishikawa, 920 0293, Japan
    BMC Gastroenterol 13:1. 2013
    ..We report an investigation into the effect of HRH2 promoter polymorphism (rs2607474 G > A) on the methylation of DAPK and CDH1...
  8. doi request reprint Role of heat-shock protein (HSP) 70-2 genotype in peptic ulcer in Japanese population
    Tomomitsu Tahara
    Department of Gastoenterology, Fujita Health University School of Medicine, Aichi, Japan
    Hepatogastroenterology 59:426-9. 2012
    ..We aimed to clarify the effect of HSP70-2 polymorphism on the risk of peptic ulcer diseases in a Japanese population...
  9. doi request reprint Synergistic effect of IL-1β and TNF-α polymorphisms on the H. pylori-related gastric pre-malignant condition
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Japan
    Hepatogastroenterology 59:2416-20. 2012
    ..We investigated the effect of IL-1β and TNF-α polymorphisms, and its synergistic effect with age, gender and H. pylori status on the gastric pre-malignant condition...
  10. doi request reprint Examination of serum pepsinogen in functional dyspepsia
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyake, Japan
    Hepatogastroenterology 59:2516-22. 2012
    ..We investigated serum PG levels and PGI/PGII ratios in dyspeptic patients, in relation to various different subtypes of symptoms including Rome III classifications...
  11. doi request reprint Potential usefulness of DNA methylation as a risk marker for digestive cancer associated with inflammation
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, 1 98 Dengakugakubo Kutsukake cho, Toyoake, Aichi, 470 1192, Japan
    Expert Rev Mol Diagn 12:489-97. 2012
    ....
  12. pmc Correlation between magnifying narrow band imaging and histopathology in gastric protruding/or polypoid lesions: a pilot feasibility trial
    Takafumi Omori
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    BMC Gastroenterol 12:17. 2012
    ..Here we assessed the diagnostic efficacy of magnifying NBI for predicting histopathology among gastric protruding/or polypoid lesions...
  13. doi request reprint Presence of minimal change esophagitis closely correlates with pathological conditions in the stomach
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    Dig Dis Sci 57:958-66. 2012
    ..We evaluated the clinical significance of grade M esophagitis, including its subtypes (reddish change: MR and whitish change: MW), especially with attempt to pathological conditions in the stomach that relates to gastric acid secretion...
  14. ncbi request reprint COMT gene Val158Met polymorphism influences the severity of intestinal metaplasia in H. pylori infected older subjects
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Japan
    Hepatogastroenterology 56:411-5. 2009
    ..We aimed to clarify the effect of COMT functional polymorphism on the severity of histological gastritis in a Japanese population...
  15. doi request reprint Homozygous TRPV1 315C influences the susceptibility to functional dyspepsia
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    J Clin Gastroenterol 44:e1-7. 2010
    ..The G315C polymorphism affects the TRPV1 gene and alters its protein level. We aimed to investigate the effect of TRPV1 G315C polymorphism on functional dyspepsia (FD) in a Japanese population...
  16. ncbi request reprint 779 TC of CCK-1 intron 1 is associated with postprandial syndrome (PDS) in Japanese male subjects
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Japan
    Hepatogastroenterology 56:1245-8. 2009
    ..A common polymorphisms of CCK and it's receptor gene has been shown to be associated with panic disorder and schizophrenia. It was investigated the prevalence of CCK polymorphism in dyspeptic patients in a Japanese population...
  17. ncbi request reprint Association between cyclin D1 (CCND1) polymorphism and gastric cancer risk in Japanese population
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Japan
    Hepatogastroenterology 56:1232-5. 2009
    ..The present study aimed to clarify the effect of G870A polymorphism of the CCND1 gene on the risk of gastric cancer (GC) in a Japanese population...
  18. ncbi request reprint Effect of polymorphisms of IL-17A, -17F and MIF genes on CpG island hyper-methylation (CIHM) in the human gastric mucosa
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Int J Mol Med 24:563-9. 2009
    ..Genetic polymorphisms of MIF-794-CATT repeat may be involved in methylation related carcinogenesis in the stomach...
  19. ncbi request reprint The BB genotype of heat-shock protein (HSP) 70-2 gene is associated with gastric pre-malignant condition in H. pylori-infected older patients
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    Anticancer Res 29:3453-8. 2009
    ..We aimed to clarify the effect of HSP70-2 polymorphism on the risk of premalignant condition, on the degree of acute or chronic inflammation in the stomach...
  20. doi request reprint Mannan-binding lectin B allele is associated with a risk of developing more severe gastric mucosal atrophy in Helicobacter pylori-infected Japanese patients
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Eur J Gastroenterol Hepatol 21:781-6. 2009
    ..We investigated the influence of MBL2 variant on the risk of gastroduodenal diseases and on the severity of Helicobacter pylori-induced gastritis in a Japanese population...
  21. doi request reprint Gastric mucosal pattern by using magnifying narrow-band imaging endoscopy clearly distinguishes histological and serological severity of chronic gastritis
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Japan
    Gastrointest Endosc 70:246-53. 2009
    ..Magnifying narrow-band imaging (NBI) endoscopy clearly visualizes superficial gastric mucosal patterns and capillary patterns...
  22. doi request reprint Chronic nonsteroidal anti-inflammatory drug (NSAID) use suppresses multiple CpG islands hyper methylation (CIHM) of tumor suppressor genes in the human gastric mucosa
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Aichi, Japan
    Cancer Sci 100:1192-7. 2009
    ..09-0.49). No association was found between CIHM status and the duration or dose of NSAIDs. Chronic NSAID use suppresses CIHM in human gastric mucosa. NSAIDs may have a suppressive role against methylation-related gastric carcinogenesis...
  23. ncbi request reprint Impact of catechol-O-methyltransferase (COMT) gene polymorphism on promoter methylation status in gastric mucosa
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Anticancer Res 29:2857-61. 2009
    ..The association between a common functional polymorphism of COMT Val158Met and DNA methylation status in the stomach was investigated...
  24. doi request reprint A genetic variant of the p22PHOX component of NADPH oxidase C242T is associated with reduced risk of functional dyspepsia in Helicobacter pylori-infected Japanese individuals
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Eur J Gastroenterol Hepatol 21:1363-8. 2009
    ..pylori-related gastric inflammation. We aimed to clarify the association between C242T polymorphism of p22PHOX, an essential component of nicotinamide adenine dinucleotide phosphate oxidase and FD in a Japanese population...
  25. ncbi request reprint RANTES promoter genotype and gastric cancer risk in a Japanese population
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    Anticancer Res 29:4265-9. 2009
    ..Elevated serum level of RANTES in gastric cancer patients was also reported. We aimed to clarify the effect of RANTES promoter polymorphism on the risk of gastric cancer (GC) in a Japanese population...
  26. ncbi request reprint Association of polymorphism of TLR4 and CD14 genes with gastroduodenal diseases in Japan
    T Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    Inflammopharmacology 15:124-8. 2007
    ..Toll like receptor 4(TLR4) and CD14-mediated recognition of lipo-polysaccharide (LPS) is required for efficient recognition of Gram-negative bacterial infections...
  27. ncbi request reprint Association between genetic polymorphisms related to DNA repair or xenobiotic pathways and gastric premalignant conditions
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Japan
    Anticancer Res 31:1459-65. 2011
    ....
  28. ncbi request reprint Host genetic factors, related to inflammatory response, influence the CpG island methylation status in colonic mucosa in ulcerative colitis
    Tomomitsu Tahara
    1 98 Dengakugakubo Kutsukake cho, Toyoake, Aichi, 470 1192, Japan
    Anticancer Res 31:933-8. 2011
    ..The influence of common single nucleotide polymorphisms (SNPs) related to inflammatory immune response on the individual susceptibility to CIHM status in the non-neoplastic rectal mucosa in UC patients was evaluated...
  29. doi request reprint Polymorphisms of DNA repair and xenobiotic genes predispose to CpG island methylation in non-neoplastic gastric mucosa
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    Helicobacter 16:99-106. 2011
    ..CpG island hyper methylation (CIHM) is a major event in gastric carcinogenesis. We evaluated the association between XRCC1, GSTP1, GSTT1 and GSTM1 polymorphisms with CIHM status in non-neoplastic gastric mucosa...
  30. ncbi request reprint Effect of genetic polymorphisms related to DNA repair and the xenobiotic pathway on the prognosis and survival of gastric cancer patients
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Japan
    Anticancer Res 31:705-10. 2011
    ....
  31. doi request reprint Effect of IL-1β and TNF-α polymorphisms on the prognosis and survival of gastric cancer patients
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Kutsukake cho, Toyoake, Aichi, Japan
    Clin Exp Med 11:211-7. 2011
    ..IL-1β-31CC, IL-1β-511TT genotype, and TNF-α-857T carrier may have protective effect against GC progression...
  32. doi request reprint Association between polymorphisms in the XRCC1 and GST genes, and CpG island methylation status in colonic mucosa in ulcerative colitis
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi, 470 1192, Japan
    Virchows Arch 458:205-11. 2011
    ..43 ± 1.03 vs. 0.84 ± 1.07, p = 0.03). XRCC1 Arg399Gln and GSTP1 Ile104Val polymorphisms may influence the CIHM status in the rectal mucosa of UC patients and may be substantially involved in UC-associated carcinogenesis...
  33. doi request reprint Promoter methylation status of multidrug resistance 1 (MDR1) gene in noncancerous gastric mucosa correlates with Helicobacter Pylori infection and gastric cancer occurrence
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Japan
    Cancer Invest 28:711-6. 2010
    ..Higher MR was also associated with Helicobacter pylori infection. Methylation status of MDR1 gene in noncancerous gastric mucosa would be useful for predicting GC occurrence...
  34. doi request reprint Influence of MDR1 polymorphism on H. pylori-related chronic gastritis
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, 470 1192, Aichi, Japan
    Dig Dis Sci 56:103-8. 2011
    ..There is evidence that changes in MDR1 function and/or expression contribute to the pathogenesis of inflammatory disorders of the gastrointestinal tract...
  35. doi request reprint Association between cyclin D1 polymorphism with CpG island promoter methylation status of tumor suppressor genes in gastric cancer
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    Dig Dis Sci 55:3449-57. 2010
    ..Cyclin D1 regulates cell cycle function and may play a role in methylation-related carcinogenesis...
  36. doi request reprint Increased number of CpG island hypermethylation in tumor suppressor genes of non-neoplastic gastric mucosa correlates with higher risk of gastric cancer
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Japan
    Digestion 82:27-36. 2010
    ..We investigated the relationship of gastric cancer (GC) and CpG island hypermethylation (CIHM) in tumor suppressor genes of non-neoplastic gastric mucosa...
  37. ncbi request reprint CpG island promoter methylation (CIHM) status of tumor suppressor genes correlates with morphological appearances of gastric cancer
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Japan
    Anticancer Res 30:239-44. 2010
    ..We aimed to investigate the association between CIHM status of tumor suppressor genes and clinicopathological and morphological characteristics of gastric cancer...
  38. ncbi request reprint Association between IL-17A, -17F and MIF polymorphisms predispose to CpG island hyper-methylation in gastric cancer
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Aichi, 470 1192, Japan
    Int J Mol Med 25:471-7. 2010
    ..Genetic polymorphisms of IL-17A, and MIF-794-CATT repeat may be involved in methylation-related carcinogenesis in the stomach...
  39. ncbi request reprint Effect of polymorphisms in the 3'-untranslated region (3'-UTR) of VEGF gene on gastric pre-malignant condition
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Anticancer Res 29:485-9. 2009
    ..A complex interaction of host genetic and environmental factors may be relevant in Helicocobacter pylori-related gastric carcinogenesis. We investigated the effect of VEGF gene polymorphisms on the risk of gastric pre-malignant condition...
  40. ncbi request reprint Effect of promoter methylation of multidrug resistance 1 (MDR1) gene in gastric carcinogenesis
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Japan
    Anticancer Res 29:337-41. 2009
    ..The methylation status of MDR1 gene promoter was investigated in gastric cancer in relation to various clinicopathological features...
  41. doi request reprint CD14 promoter-159 polymorphism is associated with reduced risk of intestinal-type gastric cancer in a Japanese population
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi, 470 1192, Japan
    Dig Dis Sci 54:1508-12. 2009
    ..pylori-infected patients of more than 61 years of age, and these genotypes may reduce the risk of intestinal-type gastric cancer...
  42. doi request reprint Effect of RANTES promoter genotype on the severity of intestinal metaplasia in Helicobacter pylori-infected Japanese subjects
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Dig Dis Sci 54:1247-52. 2009
    ..pylori-infected gastric mucosa. We aimed to clarify the effect of RANTES functional promoter polymorphism on the risk of gastro-duodenal diseases in a Japanese population...
  43. ncbi request reprint Multi-drug resistance 1 polymorphism is associated with reduced risk of gastric cancer in the Japanese population
    Tomomitsu Tahara
    Department of Gastroenterology, School of Medicine, Toyoake, Aichi, Japan
    J Gastroenterol Hepatol 22:1678-82. 2007
    ..C3435T polymorphism in exon 26 of the MDR1 gene influences P-glycoprotein expression and activity in the gastrointestinal tract. We investigated the influences of MDR1 gene polymorphism on the risk of gastric cancer...
  44. ncbi request reprint Toll-like receptor 2 -196 to 174del polymorphism influences the susceptibility of Japanese people to gastric cancer
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Aichi 470 1192, Japan
    Cancer Sci 98:1790-4. 2007
    ..There were no significant associations between TLR2 genotypes and tumor stage and anatomical location. Our data suggest that the -196 to -174del/del genotype of TLR2 may increase the risk of gastric cancer in the Japanese population...
  45. ncbi request reprint COMT gene val158met polymorphism in patients with dyspeptic symptoms
    Tomomitsu Tahara
    Department of Gastroenterology, Kanazawa Medical University, Ishikawa, Japan
    Hepatogastroenterology 55:979-82. 2008
    ..Polymorphism in codon 158 of the COMT gene influences its activity. This study aimed to clarify the association between COMT polymorphism and dyspepsia in a Japanese population...
  46. ncbi request reprint Homozygous 825T allele of the GNB3 protein influences the susceptibility of Japanese to dyspepsia
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    Dig Dis Sci 53:642-6. 2008
    ..Our data suggest that the homozygous 825T allele of GNB3 protein is associated with dyspepsia in the H. pylori-negative Japanese population. The role of genetics in the development of dyspepsia needs further evaluation...
  47. ncbi request reprint Risk prediction of gastric cancer by analysis of aberrant DNA methylation in non-neoplastic gastric epithelium
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Dengakugakubo, Kutsukake cho, Toyoake, Aichi, Japan
    Digestion 75:54-61. 2007
    ..Promoter DNA methylation is also present in various non-neoplastic tissues including gastric epithelium as age-related phenomenon, suggesting that it occurs early in the process of tumorigenesis...
  48. ncbi request reprint Influence of peroxisome proliferator-activated receptor (PPAR)gamma Plo12Ala polymorphism as a shared risk marker for both gastric cancer and impaired fasting glucose (IFG) in Japanese
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    Dig Dis Sci 53:614-21. 2008
    ..Our study suggests that the PPARgamma Pro12Ala polymorphism may be a shared risk marker of both IFG and gastric cancer in Japanese...
  49. ncbi request reprint Toll-like receptor 2 (TLR) -196 to 174del polymorphism in gastro-duodenal diseases in Japanese population
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    Dig Dis Sci 53:919-24. 2008
    ..Our data suggest that the TLR2-196 to -174ins allele was associated with more severe intestinal metaplasia in patients older than was correlated with severity of gastric mucosal atrophy and intestinal metaplasia in female subjects...
  50. doi request reprint Effect of cyclin D1 (CCND1) polymorphism on gastric premalignant condition
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine 1, Toyoake, Aichi, Japan
    Clin Chem Lab Med 46:1696-701. 2008
    ..The aim of this study was to investigate the effect of G870A polymorphism of the CCND1 gene on gastric precancerous condition, on histological chronic gastritis, and on the risk of peptic ulcer diseases...
  51. doi request reprint MTHFR 677T carrier influences the methylation status of H. pylori-infected gastric mucosa in older subjects
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Dig Dis Sci 54:2391-8. 2009
    ..0418). Our data suggest that MTHFR 677T carrier influences the risk of DNA methylation in gastric mucosa in the long-term outcome of the H. pylori infection...
  52. doi request reprint Increased number of methylated CpG islands correlates with Helicobacter pylori infection, histological and serological severity of chronic gastritis
    Tomomitsu Tahara
    Department of Gastroenterology, Kanazawa Medical University, Uchinadamachi, Kanazawa, Ishikawa, Japan
    Eur J Gastroenterol Hepatol 21:613-9. 2009
    ..Here, we examined whether methylation of multiple promoter CpG islands would occur by H. pylori infection and correlate with histological or serological severity of chronic gastritis...
  53. ncbi request reprint Effect of MDR1 gene promoter methylation in patients with ulcerative colitis
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Aichi, 470 1192, Japan
    Int J Mol Med 23:521-7. 2009
    ..MDR1 methylation frequently occurred in inflammatory rectal mucosa from UC patients and was influenced by MDR1 C3435T polymorphism, especially in patients with shorter duration and younger onset...
  54. ncbi request reprint Genetic variant of the p22PHOX component of NADPH oxidase C242T and the incidence of gastric cancer in Japan
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Japan
    Hepatogastroenterology 55:2273-6. 2008
    ..pylori related gastric inflammation. We aimed to clarify the effect of C242T polymorphism of p22PHOX, an essential component of NADPH oxidase on the risk of gastric cancer, gastric ulcer and duodenal ulcer in a Japanese population...
  55. doi request reprint Chronic aspirin use suppresses CDH1 methylation in human gastric mucosa
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    Dig Dis Sci 55:54-9. 2010
    ..Our data suggest that chronic aspirin use is associated with reduced risk of CDH1 methylation in human gastric mucosa. Aspirin may have suppressive role against methylation-related gastric carcinogenesis...
  56. doi request reprint Promoter methylation of protease-activated receptor (PAR2) is associated with severe clinical phenotypes of ulcerative colitis (UC)
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    Clin Exp Med 9:125-30. 2009
    ..The higher methylation levels were also associated with Steroid-dependent (P = 0.002) and refractory (P = 0.007) UC. Our data suggest that PAR2 methylation status in rectal mucosa correlates with more severe disease phenotypes of UC...
  57. ncbi request reprint Serotonin-2A receptor gene T102C polymorphism in patients with dyspeptic symptoms
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi, 470 1192, Japan
    Hepatogastroenterology 55:1921-4. 2008
    ..We aimed to clarify the association between 5HTR2A C102T polymorphism and dyspeptic symptom in a Japanese population...
  58. ncbi request reprint No association between a genetic variant of the p22PHOX component of NADPH oxidase C242T and ulcerative colitis
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Japan
    Hepatogastroenterology 55:1573-7. 2008
    ..pylori related gastric inflammation. We aimed to clarify the effect of C242T polymorphism of p22PHOX, an essential component of NADPH oxidase on the risk of UC in a Japanese population...
  59. doi request reprint Association of polymorphism of the p22PHOX component of NADPH oxidase in gastroduodenal diseases in Japan
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine Toyoake, Aichi, Japan
    Scand J Gastroenterol 44:296-300. 2009
    ..The aim of this study was to clarify the effect of the p22PHOX C242T polymorphism, an essential component of NADPH oxidase in the risk of gastroduodenal diseases, on the severity of H. pylori-induced gastritis in a Japanese population...
  60. ncbi request reprint Genetic polymorphisms of molecules associated with inflammation and immune response in Japanese subjects with functional dyspepsia
    Tomiyasu Arisawa
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake 470 1192, Japan
    Int J Mol Med 20:717-23. 2007
    ..pylori-infected subjects. The genetic polymorphisms of inflammation or immune response-related molecules are involved in the development of one of the FD subgroups via H. pylori-induced gastric inflammation...
  61. doi request reprint Genetic polymorphisms of cyclooxygenase-1 (COX-1) are associated with functional dyspepsia in Japanese women
    Tomiyasu Arisawa
    Department of Gatroenterology, Fujita Health University School of Medicine 1 98, Dengakugakubo, Kutsukake cho, Toyoake 470 1192, Japan
    J Womens Health (Larchmt) 17:1039-43. 2008
    ..We investigated the association between the potentially functional polymorphism T-1676C in the COX-1 gene promoter and functional dyspepsia (FD) in the Japanese population...
  62. doi request reprint Genetic polymorphisms of SCN10A are associated with functional dyspepsia in Japanese subjects
    Tomiyasu Arisawa
    Department of Gastroenterology, Kanazawa Medical University, 1 1 Daigaku, Uchinada machi, Ishikawa, 920 0293, Japan
    J Gastroenterol 48:73-80. 2013
    ..We attempted to clarify the association between functional dyspepsia (FD) and SCN10A non-synonymous polymorphisms (2884 A>G, 3218 C>T and 3275 T>C)...
  63. ncbi request reprint Association between genetic polymorphisms in the cyclooxygenase-1 gene promoter and peptic ulcers in Japan
    Tomiyasu Arisawa
    Department of Gatroenterology, Fujita Health University School of Medicine, Toyoake 470 1192, Japan
    Int J Mol Med 20:373-8. 2007
    ....
  64. ncbi request reprint Genetic polymorphisms of CD14 and Toll-like receptor-2 (TLR2) in patients with ulcerative colitis
    Fangyu Wang
    Department of Gastroenterology, School of Medicine, Fujita Health University, Toyoake, Japan
    J Gastroenterol Hepatol 22:925-9. 2007
    ..The aim of this study was to investigate the association between CD14 and Toll-like receptor-2 (TLR2) genetic polymorphisms and chronic UC in Japanese patients...
  65. doi request reprint Protective role of genetic polymorphism of heat shock protein 70-2 for gastric cancer risk
    Tomoyuki Shibata
    Department of Gastroenterology, School of Medicine, Fujita Health University, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi, 470 1192, Japan
    Dig Dis Sci 54:70-4. 2009
    ..Recently, polymorphism of HSP70-2 at position 1267 was suggested to be associated with carcinogenesis. We investigated the association of this polymorphism with the risk of gastric cancer in the present study...
  66. doi request reprint Mannan-binding lectin (MBL) polymorphism and gastric cancer risk in Japanese population
    Fang Yu Wang
    Department of Gastroenterology, Fujita Health University School of Medicine, Aichi Prefecture, 470 1192, Japan
    Dig Dis Sci 53:2904-8. 2008
    ..Mannan-binding lectin (MBL) is believed to be an important constituent of the innate immune system. It has been reported that the codon 54 G/A polymorphism of exon-1 affects the MBL2 gene and alters its activity...
  67. ncbi request reprint Functional promoter polymorphisms of the macrophage migration inhibitory factor gene in gastric carcinogenesis
    Tomiyasu Arisawa
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake 470 1192, Japan
    Oncol Rep 19:223-8. 2008
    ....
  68. ncbi request reprint Effects of -1018G>A polymorphism of HRH2 (rs2607474) on the severity of gastric mucosal atrophy
    Hideto Yamada
    Department of Gastroenterology, Kanazawa Medical University, 1 1 Daigaku, Uchinada machi, Ishikawa, Japan
    J Gastrointestin Liver Dis 21:139-43. 2012
    ..A polymorphism -1018 G>A (rs2067474) was identified in an enhancer element of the HRH2 promoter. We attempted to clarify the associations of this polymorphism with the progression of gastric mucosal atrophy...
  69. doi request reprint NFKB1 polymorphism is associated with age-related gene methylation in Helicobacter pylori-infected subjects
    Tomiyasu Arisawa
    Department of Gastroenterology, Kanazawa Medical University, Uchinada machi, Ishikawa 920 0293, Japan
    Int J Mol Med 30:255-62. 2012
    ..NFKB1 -94 ins/del ATTG polymorphism (rs28362491) was significantly associated with the increased risk for the development of age-related gene methylation in non-cancerous gastric mucosa under H. pylori-induced inflammation...
  70. pmc Selenoprotein S (SEPS1) gene -105G>A promoter polymorphism influences the susceptibility to gastric cancer in the Japanese population
    Tomoyuki Shibata
    Department of Gastroenterology, Fujita Health University, School of Medicine, Toyoake, Japan
    BMC Gastroenterol 9:2. 2009
    ..Recently the -105G>A polymorphism in the promoter of SEPS1 was shown to increase pro-inflammatory cytokine expression. We examined the association between this polymorphism and the risk of gastric cancer...
  71. ncbi request reprint Functional polymorphisms in the promoter region of macrophage migration inhibitory factor and chronic gastritis
    Tomiyasu Arisawa
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake 470 1192, Japan
    Int J Mol Med 20:539-44. 2007
    ..Our results suggested that functional promoter polymorphisms of the MIF gene might be associated with the severity of gastric mucosal inflammation in younger subjects and with the subsequent development of mucosal atrophy...
  72. ncbi request reprint The influence of polymorphisms of interleukin-17A and interleukin-17F genes on the susceptibility to ulcerative colitis
    Tomiyasu Arisawa
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98, Dengakugakubo, Kutsukake cho, Toyoake 470 1192, Japan
    J Clin Immunol 28:44-9. 2008
    ..Our results provided the first evidence that -197A (IL-17A) and 7488T (IL-17F) alleles may influence the susceptibility to and pathophysiological features of UC independently...
  73. ncbi request reprint The influence of promoter polymorphism of nuclear factor-erythroid 2-related factor 2 gene on the aberrant DNA methylation in gastric epithelium
    Tomiyasu Arisawa
    Department of Gatroenterology, Fujita Health University, School of Medicine, Toyoake 470 1192, Japan
    Oncol Rep 19:211-6. 2008
    ..027, respectively). Our results suggested that the promoter polymorphisms of Nrf2 gene may affect the methylation status of tumor-related genes, especially the p14 gene, under the influence of H. pylori-induced gastric inflammation...
  74. ncbi request reprint Promoter hypomethylation of protease-activated receptor 2 associated with carcinogenesis in the stomach
    Tomiyasu Arisawa
    Department of Gastroenterology, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan
    J Gastroenterol Hepatol 22:943-8. 2007
    ..An abnormal DNA methylation has been recognized as an important molecular mechanism for the genesis of various types of cancers. We attempted to clarify the relationship between the promoter methylation of PAR2 and gastric cancer...
  75. doi request reprint Association of endoscopic appearances with dyspeptic symptoms
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Toyoake, 470 1192, Japan
    J Gastroenterol 43:208-15. 2008
    ..We aimed to clarify the association of endoscopic appearances with Helicobacter pylori infection, histological severity of gastritis, and dyspeptic symptoms in a Japanese population...
  76. doi request reprint Effect of polymorphisms of IL-1β and TNF-α genes on CpG island hyper methylation (CIHM) in the nonneoplastic gastric mucosa
    Tomomitsu Tahara
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Mol Carcinog 50:835-45. 2011
    ..IL-1β-511 TT genotype is associated with reduced susceptibility to CIHM especially in younger generation. Furthermore, the TNF-α-857T carrier is associated with increased susceptibility of CIHM in the same generation...
  77. doi request reprint Changes in gastric mucosal patterns seen by magnifying NBI during H. pylori eradication
    Masaaki Okubo
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    J Gastroenterol 46:175-82. 2011
    ..We aimed to investigate changes in gastric mucosal patterns seen by magnifying NBI endoscopy after Helicobacter pylori eradication...
  78. doi request reprint Association study of common genetic variants in pre-microRNAs in patients with ulcerative colitis
    Masaaki Okubo
    Department of Gastroenterology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    J Clin Immunol 31:69-73. 2011
    ..We evaluated the associations of three SNPs (rs11614913, rs2910164, and rs3746444) in pre-miRNAs (miR-196a2, miR-146a, and miR-499) with the risk of ulcerative colitis (UC) in a Japanese population...
  79. doi request reprint Usefulness of magnifying narrow-band imaging endoscopy in the Helicobacter pylori-related chronic gastritis
    Masaaki Okubo
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Japan
    Digestion 83:161-6. 2011
    ..pylori eradication...
  80. ncbi request reprint Promoter polymorphism of cyclooxygenase-1 (COX1) is not associated with ulcerative colitis in the Japanese population
    Tomiyasu Arisawa
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Japan
    Hepatogastroenterology 55:987-90. 2008
    ..This study attempted to clarify the relationship between cyclooxygenase-1 (COX1) gene polymorphisms (T-1676C and A-842G/C50T) and ulcerative colitis in a Japanese population...
  81. doi request reprint Association between common genetic variants in pre-microRNAs and gastric cancer risk in Japanese population
    Masaaki Okubo
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Japan
    Helicobacter 15:524-31. 2010
    ....
  82. ncbi request reprint Nrf2 gene promoter polymorphism and gastric carcinogenesis
    Tomiyasu Arisawa
    Department of Gatroenterology, Fujita Health University School of Medicine, Toyoake, Japan
    Hepatogastroenterology 55:750-4. 2008
    ..Three gene polymorphisms of Nrf2, which regulate the expression of detoxifying and antioxidant genes, have been identified. We attempted to clarify the relationship of these polymorphisms with the carcinogenesis in the stomach...
  83. ncbi request reprint Association between promoter polymorphisms of nuclear factor-erythroid 2-related factor 2 gene and peptic ulcer diseases
    Tomiyasu Arisawa
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake 470 1192, Japan
    Int J Mol Med 20:849-53. 2007
    ..25; 95% CI, 0.088-0.73; p=0.011). Our results suggest that promoter polymorphisms of the Nrf2 gene are associated with the susceptibility to gastric ulcer...
  84. ncbi request reprint Nrf2 gene promoter polymorphism is associated with ulcerative colitis in a Japanese population
    Tomiyasu Arisawa
    Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Japan
    Hepatogastroenterology 55:394-7. 2008
    ..Three promoter polymorphisms of this gene have been identified. This study attempted to clarify the relationship between Nrf2 gene polymorphism and ulcerative colitis in a Japanese population...
  85. doi request reprint The usefulness of magnifying endoscopy with narrow-band imaging to distinguish carcinoma in flat elevated lesions in the stomach diagnosed as adenoma by using biopsy samples
    Masakatsu Nakamura
    Department of Gastroenterology, Fujita Health University, Toyoake, Japan
    Gastrointest Endosc 71:1070-5. 2010
    ....
  86. ncbi request reprint [X-ray examination of small intestine--conventional enteroclysis and CT enterography]
    Ichiro Hirata
    Department of Gastroenterology, Fujita Health University, School of Medicine
    Nihon Rinsho 66:1259-67. 2008
    ..CT enterography will be it with more and more useful examination for the small intestine in a diagnosis of intestinal neoplasia, ileus and inflammatory bowel disease such as Crohn's disease in future...