Tomomitsu Tahara

Summary

Affiliation: Graduate School
Country: Japan

Publications

  1. Horiguchi N, Tahara T, Kawamura T, Okubo M, Tahara S, Nagasaka M, et al. A Comparative Study of White Light Endoscopy, Chromoendoscopy and Magnifying Endoscopy with Narrow Band Imaging in the Diagnosis of Early Gastric Cancer after Helicobacter pylori Eradication. J Gastrointestin Liver Dis. 2017;26:357-362 pubmed publisher
    ..pylori eradication becomes lower especially using CE. Indistinguishable cases using CE are associated with histological findings such as non-tumorous epithelium on the tumor and/or surface differentiation of tumors. ..
  2. request reprint
    Tahara T, Arisawa T, Shibata T, Nakamura M, Yamashita H, Yoshioka D, et al. Effect of polymorphisms in the 3'-untranslated region (3'-UTR) of VEGF gene on gastric pre-malignant condition. Anticancer Res. 2009;29:485-9 pubmed
    ..GA; 0.98 +/- 0.87 vs. 1.55 +/- 0.96, p = 0.026). The G1612A but not the C936T polymorphism of the VEGF gene is associated with gastric pre-malignant condition in older individuals. ..
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    Tahara T, Shibata T, Nakamura M, Yamashita H, Yoshioka D, Okubo M, et al. Effect of genetic polymorphisms related to DNA repair and the xenobiotic pathway on the prognosis and survival of gastric cancer patients. Anticancer Res. 2011;31:705-10 pubmed
    ..019). XRCC1 codon 194 Trp carrier status is correlated with more aggressive biological behavior of GC, such as venous invasion, and the GSTT1 null genotype is associated with better survival in GC patients. ..
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    Tahara T, Okubo M, Shibata T, Kawamura T, Sumi K, Ishizuka T, et al. Association between common genetic variants in pre-microRNAs and prognosis of advanced gastric cancer treated with chemotherapy. Anticancer Res. 2014;34:5199-204 pubmed
    ..33 95%CI 0.18-0.75). The rs3746444 A allele carrier in the hsa-mir-499 is associated with better prognosis in advanced GC performing chemotherapy. ..
  5. Tahara T, Shibata T, Kawamura T, Ishizuka T, Okubo M, Nagasaka M, et al. Telomere length in non-neoplastic gastric mucosa and its relationship to H. pylori infection, degree of gastritis, and NSAID use. Clin Exp Med. 2016;16:65-71 pubmed publisher
    ..Telomere shortening is closely associated with severity of H. pylori-induced gastritis and CDH1 methylation status. Also, telomere shortening is accelerated by NSAID usage especially in H. pylori-negative subjects. ..
  6. Tahara T, Arisawa T, Shibata T, Nakamura M, Yoshioka D, Okubo M, et al. Increased number of methylated CpG islands correlates with Helicobacter pylori infection, histological and serological severity of chronic gastritis. Eur J Gastroenterol Hepatol. 2009;21:613-9 pubmed publisher
    ..pylori-infected participants (P=0.074). Multiple promoter CpG islands would be methylated by H. pylori infection, and an increased number of methylated CpG sites correlate with histological and serological severity of chronic gastritis. ..
  7. Tahara T, Shibata T, Nakamura M, Yamashita H, Yoshioka D, Okubo M, et al. Increased number of CpG island hypermethylation in tumor suppressor genes of non-neoplastic gastric mucosa correlates with higher risk of gastric cancer. Digestion. 2010;82:27-36 pubmed publisher
    ..pylori infection status, gender and generation. An increased number of CIHM correlates with a higher GC risk including its various clinico-pathological subtypes. ..
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    Tahara T, Arisawa T, Shibata T, Yamashita H, Yoshioka D, Hirata I. Effect of promoter methylation of multidrug resistance 1 (MDR1) gene in gastric carcinogenesis. Anticancer Res. 2009;29:337-41 pubmed
    ..005) and lymph vessel invasion-positive cases (p = 0.002). The promoter methylation of MDR1 seems to have a significant role in carcinogenesis and tumor progression in the stomach. ..
  9. Tahara T, Tahara S, Tuskamoto T, Horiguchi N, Kawamura T, Okubo M, et al. Telomere length in the gastric mucosa after Helicobacter pylori eradication and its potential role in the gastric carcinogenesis. Clin Exp Med. 2018;18:21-26 pubmed publisher
    ..01). Telomere shortening seems to be important initial steps in gastric cancer predisposition after H. pylori eradication, while it might shift to lengthening to acquire more aggressive pathway to develop cancer. ..

More Information

Publications42

  1. Tahara T, Shibata T, Kawamura T, Horiguchi N, Okubo M, Nakano N, et al. Telomere length shortening in gastric mucosa is a field effect associated with increased risk of gastric cancer. Virchows Arch. 2016;469:19-24 pubmed publisher
    ..Telomere shortening in gastric mucosa reflects a field effect in an early stage of carcinogenesis and is associated with an increased risk of GC. Telomere length in GC is not associated with clinicopathological features or prognosis. ..
  2. Tahara T, Shibata T, Nakamura M, Yoshioka D, Okubo M, Arisawa T, et al. Gastric mucosal pattern by using magnifying narrow-band imaging endoscopy clearly distinguishes histological and serological severity of chronic gastritis. Gastrointest Endosc. 2009;70:246-53 pubmed publisher
    ..Magnifying NBI endoscopy is useful for predicting H pylori infection and the histological severity of gastritis and is valuable for predicting gastric atrophy in the entire stomach. ..
  3. Tahara T, Arisawa T. Potential usefulness of DNA methylation as a risk marker for digestive cancer associated with inflammation. Expert Rev Mol Diagn. 2012;12:489-97 pubmed publisher
  4. Nomura T, Tahara T, Shiroeda H, Minato T, Matsue Y, Hayashi R, et al. Influence of HRH2 promoter polymorphism on aberrant DNA methylation of DAPK and CDH1 in the gastric epithelium. BMC Gastroenterol. 2013;13:1 pubmed publisher
    ..Our results suggest that rs2607474 GG homozygote confers a significantly increased risk for age- and inflammation-related DAPK and CDH1 methylation. ..
  5. Shibata T, Arisawa T, Tahara T, Ohkubo M, Yoshioka D, Maruyama N, et al. Selenoprotein S (SEPS1) gene -105G>A promoter polymorphism influences the susceptibility to gastric cancer in the Japanese population. BMC Gastroenterol. 2009;9:2 pubmed publisher
    ..This polymorphism may influence the inflammatory conditions of gastric mucosa. Larger population-based studies are needed for clarifying the relation between inflammatory responses and SEPS1 polymorphism. ..
  6. Tahara T, Shibata T, Wang F, Nakamura M, Yamashita H, Yoshioka D, et al. Mannan-binding lectin B allele is associated with a risk of developing more severe gastric mucosal atrophy in Helicobacter pylori-infected Japanese patients. Eur J Gastroenterol Hepatol. 2009;21:781-6 pubmed publisher
    ..others; odds ratio=10.06, 95% confidence interval=1.26-80.45). Our data suggest that the MBL2 codon 54 B allele is associated with a risk of developing more severe gastric mucosal atrophy in H. pylori-infected Japanese patients. ..
  7. Tahara T, Shibata T, Nakamura M, Okubo M, Yamashita H, Yoshioka D, et al. Association between polymorphisms in the XRCC1 and GST genes, and CpG island methylation status in colonic mucosa in ulcerative colitis. Virchows Arch. 2011;458:205-11 pubmed publisher
    ..43?±?1.03 vs. 0.84?±?1.07, p?=?0.03). XRCC1 Arg399Gln and GSTP1 Ile104Val polymorphisms may influence the CIHM status in the rectal mucosa of UC patients and may be substantially involved in UC-associated carcinogenesis. ..
  8. Tahara T, Shibata T, Nakamura M, Okubo M, Yamashita H, Yoshioka D, et al. Polymorphisms of DNA repair and xenobiotic genes predispose to CpG island methylation in non-neoplastic gastric mucosa. Helicobacter. 2011;16:99-106 pubmed publisher
    ..GSTM1 null genotype may increase the susceptibility to CIHM especially in older patients. Genetic factors, related to DNA repair or xenobiotic pathways may have a role in CIHM-related gastric carcinogenesis. ..
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    Tahara T, Arisawa T, Shibata T, Wang F, Nakamura M, Sakata M, et al. Homozygous 825T allele of the GNB3 protein influences the susceptibility of Japanese to dyspepsia. Dig Dis Sci. 2008;53:642-6 pubmed
    ..Our data suggest that the homozygous 825T allele of GNB3 protein is associated with dyspepsia in the H. pylori-negative Japanese population. The role of genetics in the development of dyspepsia needs further evaluation. ..
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    Tahara T, Shibata T, Nakamura M, Yamashita H, Yoshioka D, Okubo M, et al. Effect of MDR1 gene promoter methylation in patients with ulcerative colitis. Int J Mol Med. 2009;23:521-7 pubmed
    ..MDR1 methylation frequently occurred in inflammatory rectal mucosa from UC patients and was influenced by MDR1 C3435T polymorphism, especially in patients with shorter duration and younger onset. ..
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    Tahara T, Arisawa T, Wang F, Shibata T, Nakamura M, Sakata M, et al. Toll-like receptor 2 (TLR) -196 to 174del polymorphism in gastro-duodenal diseases in Japanese population. Dig Dis Sci. 2008;53:919-24 pubmed
    ..Our data suggest that the TLR2-196 to -174ins allele was associated with more severe intestinal metaplasia in patients older than was correlated with severity of gastric mucosal atrophy and intestinal metaplasia in female subjects. ..
  12. Tahara T, Arisawa T, Shibata T, Yamashita H, Nakamura M, Yoshioka D, et al. Role of heat-shock protein (HSP) 70-2 genotype in peptic ulcer in Japanese population. Hepatogastroenterology. 2012;59:426-9 pubmed publisher
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    Tahara T, Shibata T, Nakamura M, Yamashita H, Yoshioka D, Okubo M, et al. Association between genetic polymorphisms related to DNA repair or xenobiotic pathways and gastric premalignant conditions. Anticancer Res. 2011;31:1459-65 pubmed
    ..42, 95% CI=1.37-4.26, p=0.002, gastric ulcer: OR=2.18, 95% CI=1.11-4.29, p=0.025, duodenal ulcer: OR=2.62, 95% CI=1.15-6.00, p=0.023). Both the GSTT1 and GSTM1 null genotypes are associated with gastric pre-malignant conditions. ..
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    Tahara T, Arisawa T, Shibata T, Hirata I, Nakano H. Association of polymorphism of TLR4 and CD14 genes with gastroduodenal diseases in Japan. Inflammopharmacology. 2007;15:124-8 pubmed
    ..pylori infected patients more than 61 years of age, and these genotypes may reduce the risk of intestinal type gastric cancer and TLR4 Asp299Gly, Thr399Ile are very rare in the Japanese population. ..
  15. Tahara T, Tahara S, Horiguchi N, Kawamura T, Okubo M, Yamada H, et al. Methylation status of IGF2 DMR and LINE1 in leukocyte DNA provides distinct clinicopathological features of gastric cancer patients. Clin Exp Med. 2018;18:215-220 pubmed publisher
    ..04). Our data suggest that high LINE1 and IGF2 DMR methylation status would be a phenomenon that is observed with the progression of GC, supporting their potential utility as a biomarker in GC patients. ..
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    Tahara T, Shibata T, Arisawa T, Nakamura M, Yamashita H, Yoshioka D, et al. CpG island promoter methylation (CIHM) status of tumor suppressor genes correlates with morphological appearances of gastric cancer. Anticancer Res. 2010;30:239-44 pubmed
    ..The present results suggest that CIHM of DAPK and CIHM-high were associated with the morphological appearance of depressed type with ulceration in early gastric cancer, and Borrmann type IV advanced gastric cancer, respectively. ..
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    Tahara T, Arisawa T, Wang F, Shibata T, Nakamura M, Sakata M, et al. Toll-like receptor 2 -196 to 174del polymorphism influences the susceptibility of Japanese people to gastric cancer. Cancer Sci. 2007;98:1790-4 pubmed
    ..There were no significant associations between TLR2 genotypes and tumor stage and anatomical location. Our data suggest that the -196 to -174del/del genotype of TLR2 may increase the risk of gastric cancer in the Japanese population. ..
  18. request reprint
    Tahara T, Shibata T, Nakamura M, Yamashita H, Yoshioka D, Okubo M, et al. Effect of polymorphisms of IL-17A, -17F and MIF genes on CpG island hyper-methylation (CIHM) in the human gastric mucosa. Int J Mol Med. 2009;24:563-9 pubmed
    ..Genetic polymorphisms of MIF-794-CATT repeat may be involved in methylation related carcinogenesis in the stomach. ..
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    Tahara T, Arisawa T, Shibata T, Nakamura M, Wang F, Yoshioka D, et al. 779 TC of CCK-1 intron 1 is associated with postprandial syndrome (PDS) in Japanese male subjects. Hepatogastroenterology. 2009;56:1245-8 pubmed
    ..Our data suggest that the 779 T carriers of CCK-1 intron 1 is associated with an increased risk of PDS in Japanese male subjects. ..
  20. Tahara T, Shibata T, Nakamura M, Yamashita H, Yoshioka D, Hirata I, et al. Homozygous TRPV1 315C influences the susceptibility to functional dyspepsia. J Clin Gastroenterol. 2010;44:e1-7 pubmed publisher
    ..02) during cold carbonated water drinking were significantly lower among 315CC genotypes compared with others. Homozygous TRPV1 315C influences the susceptibility to FD through altering the upper gastrointestinal sensation. ..
  21. Tahara T, Shibata T, Yamashita H, Yoshioka D, Hirata I, Arisawa T. Promoter methylation status of multidrug resistance 1 (MDR1) gene in noncancerous gastric mucosa correlates with Helicobacter Pylori infection and gastric cancer occurrence. Cancer Invest. 2010;28:711-6 pubmed publisher
    ..Higher MR was also associated with Helicobacter pylori infection. Methylation status of MDR1 gene in noncancerous gastric mucosa would be useful for predicting GC occurrence. ..
  22. Tahara T, Shibata T, Nakamura M, Yamashita H, Yoshioka D, Okubo M, et al. Effect of IL-1? and TNF-? polymorphisms on the prognosis and survival of gastric cancer patients. Clin Exp Med. 2011;11:211-7 pubmed publisher
    ..IL-1?-31CC, IL-1?-511TT genotype, and TNF-?-857T carrier may have protective effect against GC progression. ..
  23. Tahara T, Shibata T, Wang F, Nakamura M, Sakata M, Nakano H, et al. A genetic variant of the p22PHOX component of NADPH oxidase C242T is associated with reduced risk of functional dyspepsia in Helicobacter pylori-infected Japanese individuals. Eur J Gastroenterol Hepatol. 2009;21:1363-8 pubmed publisher
    ..05-0.73). No significant correlation was found between p22PHOX polymorphism and a different subgroup of FD. Our data suggest that C242T carriers status is inversely related to the risk of FD in H. pylori-infected patients. ..
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    Tahara T, Arisawa T, Shibata T, Nakamura M, Wang F, Hirata I. COMT gene val158met polymorphism in patients with dyspeptic symptoms. Hepatogastroenterology. 2008;55:979-82 pubmed
    ..The data suggest that the COMT genotype seems to influence the susceptibility of dyspepsia when it interacts with gender and age. The role of genetics in the development of dyspepsia needs to further evaluation. ..
  25. Tahara T, Yamazaki J, Tahara S, Okubo M, Kawamura T, Horiguchi N, et al. Magnifying narrow-band imaging of gastric mucosal morphology predicts the H. pylori-related epigenetic field defect. Sci Rep. 2017;7:3090 pubmed publisher
    ..Endoscopic identification of "field defect" has important implications for preventing gastric cancer. Our results suggest that magnifying NBI of gastric mucosal morphology predicts a "field defect" in the gastric mucosa. ..
  26. Tahara T, Tahara S, Tuskamoto T, Horiguchi N, Yoshida D, Kawamura T, et al. Magnifying NBI Patterns of Gastric Mucosa After Helicobacter pylori Eradication and Its Potential Link to the Gastric Cancer Risk. Dig Dis Sci. 2017;: pubmed publisher
    ..pylori eradication for gastric ulcer. Magnifying the NBI pattern well correlates with pathological status of gastric mucosa after H. pylori eradication and may predict gastric cancer occurrence. ..
  27. request reprint
    Tahara T, Arisawa T, Shibata T, Hirata I, Nakano H. Multi-drug resistance 1 polymorphism is associated with reduced risk of gastric cancer in the Japanese population. J Gastroenterol Hepatol. 2007;22:1678-82 pubmed
    ..30; 95% CI = 0.10-0.91), and lymph node metastasis (OR = 0.28; 95% CI = 0.13-0.65). Our data suggest that 3435T/T polymorphism of MDR1 is associated with a reduced risk of gastric cancer in the Japanese population. ..
  28. request reprint
    Tahara T, Shibata T, Arisawa T, Nakamura M, Yoshioka D, Okubo M, et al. The BB genotype of heat-shock protein (HSP) 70-2 gene is associated with gastric pre-malignant condition in H. pylori-infected older patients. Anticancer Res. 2009;29:3453-8 pubmed
    ..37, 95% confidence interval =0.16-0.84, p=0.0172). The BB genotype of HSP70-2 gene is associated with a reduced risk of gastric pre-malignant condition in H. pylori-infected older individuals. ..
  29. Tahara T, Shibata T, Yamashita H, Nakamura M, Yoshioka D, Okubo M, et al. Chronic nonsteroidal anti-inflammatory drug (NSAID) use suppresses multiple CpG islands hyper methylation (CIHM) of tumor suppressor genes in the human gastric mucosa. Cancer Sci. 2009;100:1192-7 pubmed publisher
    ..09-0.49). No association was found between CIHM status and the duration or dose of NSAIDs. Chronic NSAID use suppresses CIHM in human gastric mucosa. NSAIDs may have a suppressive role against methylation-related gastric carcinogenesis. ..
  30. Tahara T, Shibata T, Nakamura M, Yamashita H, Yoshioka D, Okubo M, et al. Promoter methylation of protease-activated receptor (PAR2) is associated with severe clinical phenotypes of ulcerative colitis (UC). Clin Exp Med. 2009;9:125-30 pubmed publisher
    ..The higher methylation levels were also associated with Steroid-dependent (P = 0.002) and refractory (P = 0.007) UC. Our data suggest that PAR2 methylation status in rectal mucosa correlates with more severe disease phenotypes of UC. ..
  31. Tahara T, Shibata T, Nakamura M, Yamashita H, Yoshioka D, Okubo M, et al. MTHFR 677T carrier influences the methylation status of H. pylori-infected gastric mucosa in older subjects. Dig Dis Sci. 2009;54:2391-8 pubmed publisher
    ..0418). Our data suggest that MTHFR 677T carrier influences the risk of DNA methylation in gastric mucosa in the long-term outcome of the H. pylori infection. ..
  32. request reprint
    Tahara T, Tahara S, Horiguchi N, Kawamura T, Okubo M, Ishizuka T, et al. Telomere Length in Leukocyte DNA in Gastric Cancer Patients and its Association with Clinicopathological Features and Prognosis. Anticancer Res. 2017;37:1997-2001 pubmed
    ..052 and 0.059, respectively). Telomere shortening in leukocyte DNA is associated with advanced stage and poor prognosis of GC, which may reflect their reduced immune response capacity or increased chromosome instability. ..
  33. request reprint
    Tahara T, Arisawa T, Shibata T, Nakamura M, Wang F, Maruyama N, et al. Influence of peroxisome proliferator-activated receptor (PPAR)gamma Plo12Ala polymorphism as a shared risk marker for both gastric cancer and impaired fasting glucose (IFG) in Japanese. Dig Dis Sci. 2008;53:614-21 pubmed
    ..Our study suggests that the PPARgamma Pro12Ala polymorphism may be a shared risk marker of both IFG and gastric cancer in Japanese. ..