Emi K Nishimura

Summary

Affiliation: Graduate School
Country: Japan

Publications

  1. ncbi request reprint Dominant role of the niche in melanocyte stem-cell fate determination
    Emi K Nishimura
    Department of Molecular Genetics and Department of Dermatology, Graduate School of Medicine, Kyoto University, Shogoin Kawaharacho 53, Sakyo ku, Kyoto 606 8507, Japan
    Nature 416:854-60. 2002
  2. ncbi request reprint Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF
    Jinyan Du
    Department of Pediatric Hematology Oncology, Dana Farber Cancer Institute and Boston Children s Hospital, Boston, MA 02115, USA
    Cancer Cell 6:565-76. 2004
  3. ncbi request reprint Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche
    Emi K Nishimura
    Department of Pediatric Hematology Oncology, Melanoma Program in Medical Oncology, Dana Farber Cancer Institute, Boston Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 307:720-4. 2005
  4. ncbi request reprint c-Met expression is regulated by Mitf in the melanocyte lineage
    Gael G McGill
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    J Biol Chem 281:10365-73. 2006
  5. doi request reprint Inhibition of PAX3 by TGF-beta modulates melanocyte viability
    Guang Yang
    Department of Medical Oncology, Dana Farber Cancer Institute, Children s Hospital Boston, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Mol Cell 32:554-63. 2008
  6. ncbi request reprint Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability
    Gael G McGill
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cell 109:707-18. 2002
  7. ncbi request reprint [Stem cells in the mammalian hair follicle]
    Masatake Osawa
    Dana Farber Cancer Institute, Harvard University, USA
    Tanpakushitsu Kakusan Koso 49:727-33. 2004
  8. ncbi request reprint Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning
    John A D'Orazio
    Melanoma Program, Dana Farber Cancer Institute and Children s Hospital, 44 Binney Street, Boston, Massachusetts 02115, USA
    Nature 443:340-4. 2006
  9. ncbi request reprint Epistatic connections between microphthalmia-associated transcription factor and endothelin signaling in Waardenburg syndrome and other pigmentary disorders
    Kayo Sato-Jin
    Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan
    FASEB J 22:1155-68. 2008

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Dominant role of the niche in melanocyte stem-cell fate determination
    Emi K Nishimura
    Department of Molecular Genetics and Department of Dermatology, Graduate School of Medicine, Kyoto University, Shogoin Kawaharacho 53, Sakyo ku, Kyoto 606 8507, Japan
    Nature 416:854-60. 2002
    ..Our data indicate that the niche has a dominant role in the fate determination of melanocyte stem-cell progeny...
  2. ncbi request reprint Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF
    Jinyan Du
    Department of Pediatric Hematology Oncology, Dana Farber Cancer Institute and Boston Children s Hospital, Boston, MA 02115, USA
    Cancer Cell 6:565-76. 2004
    ..Collectively, these data indicate that CDK2 activity in melanoma is largely maintained at the transcriptional level by MITF, and unlike other malignancies, it may be a suitable drug target in melanoma...
  3. ncbi request reprint Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche
    Emi K Nishimura
    Department of Pediatric Hematology Oncology, Melanoma Program in Medical Oncology, Dana Farber Cancer Institute, Boston Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 307:720-4. 2005
    ..Furthermore, physiologic aging of melanocyte stem cells was associated with ectopic pigmentation or differentiation within the niche, a process accelerated by mutation of the melanocyte master transcriptional regulator Mitf...
  4. ncbi request reprint c-Met expression is regulated by Mitf in the melanocyte lineage
    Gael G McGill
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    J Biol Chem 281:10365-73. 2006
    ..Finally, dominant-negative inhibition of Mitf resulted in profound resistance of melanocytes and melanoma cells to HGF-dependent matrix invasion, suggesting a physiologic role for this pathway in melanocytic development and melanoma...
  5. doi request reprint Inhibition of PAX3 by TGF-beta modulates melanocyte viability
    Guang Yang
    Department of Medical Oncology, Dana Farber Cancer Institute, Children s Hospital Boston, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Mol Cell 32:554-63. 2008
    ....
  6. ncbi request reprint Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability
    Gael G McGill
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cell 109:707-18. 2002
    ..This linkage helps explain the vital roles of both Mitf and Bcl2 in the melanocyte lineage and the well-known treatment resistance of melanoma...
  7. ncbi request reprint [Stem cells in the mammalian hair follicle]
    Masatake Osawa
    Dana Farber Cancer Institute, Harvard University, USA
    Tanpakushitsu Kakusan Koso 49:727-33. 2004
  8. ncbi request reprint Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning
    John A D'Orazio
    Melanoma Program, Dana Farber Cancer Institute and Children s Hospital, 44 Binney Street, Boston, Massachusetts 02115, USA
    Nature 443:340-4. 2006
    ..These data emphasize the essential role of intercellular MSH signalling in the tanning response, and suggest a clinical strategy for topical small-molecule manipulation of pigmentation...
  9. ncbi request reprint Epistatic connections between microphthalmia-associated transcription factor and endothelin signaling in Waardenburg syndrome and other pigmentary disorders
    Kayo Sato-Jin
    Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan
    FASEB J 22:1155-68. 2008
    ..Collectively these data provide mechanistic and epistatic links between MITF and EDN/EDNRB, critical melanocytic survival factors and WS genes...