Kennosuke Karube

Summary

Affiliation: Graduate School
Country: Japan

Publications

  1. doi request reprint The relationship of FOXP3 expression and clinicopathological characteristics in adult T-cell leukemia/lymphoma
    Kennosuke Karube
    Department of Pathology, School of Medicine, Kurume University, Kurume, Japan
    Mod Pathol 21:617-25. 2008
  2. ncbi request reprint Adult T-cell lymphoma/leukemia with angioimmunoblastic T-cell lymphomalike features: Report of 11 cases
    Kennosuke Karube
    Department of Pathology, School of Medicine, Kurume University, Kurume, Japan
    Am J Surg Pathol 31:216-23. 2007
  3. ncbi request reprint CD10-MUM1+ follicular lymphoma lacks BCL2 gene translocation and shows characteristic biologic and clinical features
    Kennosuke Karube
    Department of Pathology, State Key Laboratory of Cancer Biology, Xijing Hospital, Fourth Military Medical University, Xi an, Shannxi, People s Republic of China
    Blood 109:3076-9. 2007
  4. ncbi request reprint Gene expression profile of cytokines and chemokines in microdissected primary Hodgkin and Reed-Sternberg (HRS) cells: high expression of interleukin-11 receptor alpha
    K Karube
    Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan
    Ann Oncol 17:110-6. 2006
  5. doi request reprint Usefulness of flow cytometry for differential diagnosis of precursor and peripheral T-cell and NK-cell lymphomas: analysis of 490 cases
    Kennosuke Karube
    Department of Pathology, School of Medicine, Kurume University, Kurume, and JSPS, Chiyoda, Tokyo, Japan
    Pathol Int 58:89-97. 2008
  6. doi request reprint BCL6 gene amplification/3q27 gain is associated with unique clinicopathological characteristics among follicular lymphoma without BCL2 gene translocation
    Kennosuke Karube
    Department of Pathology, School of Medicine, Kurume University, Kurume, Japan
    Mod Pathol 21:973-8. 2008
  7. ncbi request reprint Differential chemokine, chemokine receptor and cytokine expression in Epstein-Barr virus-associated lymphoproliferative diseases
    Koichi Ohshima
    Department of Pathology, School of Medicine, Fukuoka University, Nanakuma 7 45 1, Jonan ku, Fukuoka 814 01, Japan
    Leuk Lymphoma 44:1367-78. 2003
  8. ncbi request reprint Imbalances of chemokines, chemokine receptors and cytokines in Hodgkin lymphoma: classical Hodgkin lymphoma vs. Hodgkin-like ATLL
    Koichi Ohshima
    Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan
    Int J Cancer 106:706-12. 2003
  9. doi request reprint Estimation of the relationship between caspase-3 expression and clinical outcome of Burkitt's and Burkitt-like lymphoma
    Yuko Nomura
    Department of Pathology, School of Medicine, Kurume University, Asahimati 67, Kurume, Japan
    Cancer Sci 99:1564-9. 2008
  10. ncbi request reprint Bcl2-negative follicular lymphomas frequently have Bcl6 translocation and/or Bcl6 or p53 expression
    Ying Guo
    Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan
    Pathol Int 57:148-52. 2007

Collaborators

Detail Information

Publications41

  1. doi request reprint The relationship of FOXP3 expression and clinicopathological characteristics in adult T-cell leukemia/lymphoma
    Kennosuke Karube
    Department of Pathology, School of Medicine, Kurume University, Kurume, Japan
    Mod Pathol 21:617-25. 2008
    ..005). FOXP3 expression in adult T-cell leukemia/lymphoma thus reflects morphological features and is clinically and pathologically associated with an immunosuppressive state...
  2. ncbi request reprint Adult T-cell lymphoma/leukemia with angioimmunoblastic T-cell lymphomalike features: Report of 11 cases
    Kennosuke Karube
    Department of Pathology, School of Medicine, Kurume University, Kurume, Japan
    Am J Surg Pathol 31:216-23. 2007
    ..Almost all patients showed aggressive clinical course and poor survival (median survival: 5 mo). This is the first report of ATLL with AILT-like morphologic features...
  3. ncbi request reprint CD10-MUM1+ follicular lymphoma lacks BCL2 gene translocation and shows characteristic biologic and clinical features
    Kennosuke Karube
    Department of Pathology, State Key Laboratory of Cancer Biology, Xijing Hospital, Fourth Military Medical University, Xi an, Shannxi, People s Republic of China
    Blood 109:3076-9. 2007
    ..Our results indicate that CD10-MUM1+ FL is different from typical FL with respect to biologic and clinical features...
  4. ncbi request reprint Gene expression profile of cytokines and chemokines in microdissected primary Hodgkin and Reed-Sternberg (HRS) cells: high expression of interleukin-11 receptor alpha
    K Karube
    Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan
    Ann Oncol 17:110-6. 2006
    ..In contrast, only few cases were positive for IL-11Ralpha in B cell lymphoma, diffuse large cell lymphoma and follicular lymphoma. This is the first analysis report of tissue HRS cells with cDNA microarray technique...
  5. doi request reprint Usefulness of flow cytometry for differential diagnosis of precursor and peripheral T-cell and NK-cell lymphomas: analysis of 490 cases
    Kennosuke Karube
    Department of Pathology, School of Medicine, Kurume University, Kurume, and JSPS, Chiyoda, Tokyo, Japan
    Pathol Int 58:89-97. 2008
    ..Phenotypic analysis using FCM was thus found to be useful for differential diagnosis of T-cell and NK-cell lymphomas...
  6. doi request reprint BCL6 gene amplification/3q27 gain is associated with unique clinicopathological characteristics among follicular lymphoma without BCL2 gene translocation
    Kennosuke Karube
    Department of Pathology, School of Medicine, Kurume University, Kurume, Japan
    Mod Pathol 21:973-8. 2008
    ..BCL6 gene aberration, especially amplification/3q27 gain, indicates the presence of certain morphological and phenotypical findings in follicular lymphoma cases without IGH/BCL2 rearrangement...
  7. ncbi request reprint Differential chemokine, chemokine receptor and cytokine expression in Epstein-Barr virus-associated lymphoproliferative diseases
    Koichi Ohshima
    Department of Pathology, School of Medicine, Fukuoka University, Nanakuma 7 45 1, Jonan ku, Fukuoka 814 01, Japan
    Leuk Lymphoma 44:1367-78. 2003
    ..Our study demonstrated the enormous potential of gene expression profiling for clarifying the pathogenesis of EBV-associated diseases...
  8. ncbi request reprint Imbalances of chemokines, chemokine receptors and cytokines in Hodgkin lymphoma: classical Hodgkin lymphoma vs. Hodgkin-like ATLL
    Koichi Ohshima
    Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan
    Int J Cancer 106:706-12. 2003
    ..Our results indicate that local immunologic disorder or imbalance appears to influence the formation of H&RS cells and that in HL-like ATLL, HTLV-1 infection might not be necessary for H&RS cell formation...
  9. doi request reprint Estimation of the relationship between caspase-3 expression and clinical outcome of Burkitt's and Burkitt-like lymphoma
    Yuko Nomura
    Department of Pathology, School of Medicine, Kurume University, Asahimati 67, Kurume, Japan
    Cancer Sci 99:1564-9. 2008
    ..We suggest that caspase-3 may function as an indicator of the prognosis of BL/BLL. Furthermore, intensive short-term chemotherapeutic regimens may improve the prognosis of the patients in the low caspase-3 group...
  10. ncbi request reprint Bcl2-negative follicular lymphomas frequently have Bcl6 translocation and/or Bcl6 or p53 expression
    Ying Guo
    Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan
    Pathol Int 57:148-52. 2007
    ..These results indicate that the Bcl6 translocation occurs more frequently in Bcl2-negative FL. Furthermore, other prosurvival proteins such as p53 and Bcl6 may play an important role in the pathogenesis of Bcl2-negative FL...
  11. ncbi request reprint Upregulation of CC chemokine ligand 18 and downregulation of CX3C chemokine receptor 1 expression in human T-cell leukemia virus type 1-associated lymph node lesions: Results of chemokine and chemokine receptor DNA chip analysis
    Kei Shimizu
    Department of Pathology, School of Medicine, Kurume University, 67 Asahi Machi, Kurume, Fukuoka, Japan
    Cancer Sci 98:1875-80. 2007
    ..05). These results suggest that upregulation of CCL18 expression and downregulation of CX3CR1 expression play a role in immune responses against the ATLL cells...
  12. ncbi request reprint Downregulation of RCAS1 and upregulation of cytotoxic T cells affects synovial proliferation and apoptosis in rheumatoid arthritis
    Shiro Yoshida
    Department of Pathology, School of Medicine, Kurume University, Kurume, Japan
    J Rheumatol 35:1716-22. 2008
    ....
  13. ncbi request reprint Th1, Th2, and activated T-cell marker and clinical prognosis in peripheral T-cell lymphoma, unspecified: comparison with AILD, ALCL, lymphoblastic lymphoma, and ATLL
    Takeshi Tsuchiya
    Department of Pathology and Internal Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan
    Blood 103:236-41. 2004
    ..Our results indicate that further subtyping of PTCL, unspecified, into groups 1 and 2 could be significant for evaluating prognosis and understanding the functional role of these tumors...
  14. ncbi request reprint A "floral" variant of nodal marginal zone lymphoma
    Kennosuke Karube
    Department of Pathology, School of Medicine, Fukuoka University, Fukuoka 814 0180, Japan
    Hum Pathol 36:202-6. 2005
    ..This variant should be differentiated from the usual nodal marginal zone lymphoma because of its specific clinical and pathological features...
  15. ncbi request reprint Apoptosis- and cell cycle-associated gene expression profiling of histiocytic necrotising lymphadenitis
    Koichi Ohshima
    Department of Pathology, School of Medicine, Fukuoka University, Nanakuma 7 45 1, Jonan ku, Fukuoka 814 0180, Japan
    Eur J Haematol 72:322-9. 2004
    ..In addition, cell cycle-associated genes were upregulated in all. These findings confirm that both apoptosis and proliferation are simultaneously present in HNL lesions...
  16. doi request reprint Distribution of malignant lymphoma in Japan: analysis of 2260 cases, 2001-2006
    Ryosuke Aoki
    Department of Pathology, School of Medicine, Kurume University, Kurume, Japan
    Pathol Int 58:174-82. 2008
    ..This epidemiological study shows that the distribution patterns of malignant lymphoma differ especially in Kyushu and Okinawa, the endemic area of human T-cell leukemia/lymphoma virus type 1...
  17. doi request reprint Estimation of apoptosis and cell proliferation in histiocytic necrotizing lymphadenitis using immunohistochemical double staining
    Yuko Nomura
    Department of Pathology, School of Medicine, Kurume University, Kurume, Japan
    Pathol Int 58:98-103. 2008
    ..6%) was higher than that in the area without obvious apoptotic features (16.3%). A proportion of cells in HNL undergo proliferation and apoptosis simultaneously, such as neoplastic cells, thereby exhibiting rapid cell cycles...
  18. doi request reprint High-grade mature B-cell lymphoma with Burkitt-like morphology: results of a clinicopathological study of 72 Japanese patients
    Yuko Nomura
    Department of Pathology, School of Medicine, Kurume University, Asahimati 67, Kurume 830 0011, Japan
    Cancer Sci 99:246-52. 2008
    ..4; confidence interval 2.0-9.7; P = 0.0003). We concluded that aggressive short-term chemotherapy improves survival in BL/BLL, regardless of its genetic and immunophenotypic features...
  19. ncbi request reprint Oncogene associated cDNA microarray analysis shows PRAME gene expression is a marker for response to anthracycline containing chemotherapy in patients with diffuse large B-cell lymphoma
    Riko Kawano
    First Department of Internal Medicine, School of Medicine, Fukuoka University
    J Clin Exp Hematop 49:1-7. 2009
    ..0373). Our results therefore indicate that PRAME expression in DLBCL correlates with response to anthracycline containing chemotherapy...
  20. ncbi request reprint CXCR3-positive B cells found at elevated frequency in the peripheral blood of patients with MALT lymphoma are attracted by MIG and belong to the lymphoma clone
    Hiroaki Suefuji
    Department of Pathology, School of Medicine, Fukuoka University, Fukuoka 814 0180, Japan
    Int J Cancer 114:896-901. 2005
    ..It seemed to be associated with the dissemination of MALT lymphoma...
  21. ncbi request reprint The comparison of expression of cutaneous lymphocyte-associated antigen (CLA), and Th1- and Th2-associated antigens in mycosis fungoides and cutaneous lesions of adult T-cell leukemia/lymphoma
    Takahiro Yamaguchi
    Department of Pathology, School of Medicine, Fukuoka University, Nanakuma 7 45 1, Jonan ku, Fukuoka, 814 0180, Japan
    Eur J Dermatol 13:553-9. 2003
    ..And OX40 could be a useful immunohistochemical marker for the histopathological progression of both disorders...
  22. ncbi request reprint Clinicopathological states of Epstein-Barr virus-associated T/NK-cell lymphoproliferative disorders (severe chronic active EBV infection) of children and young adults
    Keiko Suzuki
    First Department of Internal Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan
    Int J Oncol 24:1165-74. 2004
    ..The EBV genotype did not differ between the groups. Our findings support an important pathogenic role for EBV-infected T/NK-cell infection, rather than the EBV state, in CAEBV and consequent EBV-associated NK/T-neoplasia...
  23. ncbi request reprint Expression of FoxP3, a key molecule in CD4CD25 regulatory T cells, in adult T-cell leukaemia/lymphoma cells
    Kennosuke Karube
    Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan
    Br J Haematol 126:81-4. 2004
    ..Real-time polymerase chain reaction and immunostaining detected FoxP3 expression in 10 ATLL cases, but was relatively down-regulated compared with Treg from normal subjects. These results indicate the association of ATLL and Treg...
  24. ncbi request reprint Classification of distinct subtypes of peripheral T-cell lymphoma unspecified, identified by chemokine and chemokine receptor expression: Analysis of prognosis
    Koichi Ohshima
    Department of Pathology, School of Medicine, Fukuoka University, 7 45 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Int J Oncol 25:605-13. 2004
    ..The prognosis was poor for ATLL, intermediate for AILD and favorable for ALCL (P=0.0014). Among PTCL-U, CCR4 type, CXCR3 type and CCR3 type had prognoses equivalent to ATLL, AILD and ALCL, respectively (P<0.0001)...
  25. ncbi request reprint Hepatocellular apoptosis associated with cytotoxic T/natural killer-cell infiltration in chronic active EBV infection
    Yuko Nomura
    Department of Pathology, School of Medicine, Kurume University, Kurume, Japan
    Pathol Int 59:438-42. 2009
    ..The present findings suggest that in patients with CAEBV, cytotoxic T/NK cells may directly induce hepatocytes to undergo apoptosis more frequently than they do cells in other organs of the reticulo-endothelial system...
  26. doi request reprint Mantle cell lymphoma shows three morphological evolutions of classical, intermediate, and aggressive forms, which occur in parallel with increased labeling index of cyclin D1 and Ki-67
    Yoshizo Kimura
    Department of Pathology, School of Medicine, Kurume University, Kurume, Japan
    Cancer Sci 101:806-14. 2010
    ..The diagnosis of intermediate MCL thus proved to be of major significance and should enable the design of more tailored therapies...
  27. ncbi request reprint Non-B, non-T neoplasms with lymphoblast morphology: further clarification and classification
    Kennosuke Karube
    Department of Pathology, School of Medicine, Fukuoka University, Nanakuma 7 45 1, Jonan ku, Fukuoka 814 0180, Japan
    Am J Surg Pathol 27:1366-74. 2003
    ..0089)...
  28. doi request reprint Classical Hodgkin lymphoma, lymphocyte depleted type: clinicopathological analysis and prognostic comparison with other types of classical Hodgkin lymphoma
    Kennosuke Karube
    Department of Pathology, School of Medicine, Kurume University, Japan
    Pathol Res Pract 209:201-7. 2013
    ..41%; P=0.002). LD should be distinguished from other types of classical Hodgkin lymphoma because of its definitive clinicopathological characters...
  29. doi request reprint Clinicopathological analysis of a composite lymphoma containing both T- and B-cell lymphomas
    Nobuko Suefuji
    Department of Pathology, School of Medicine, Kurume University, Kurume, Japan
    Pathol Int 62:690-8. 2012
    ..Using PCR analysis, clonal IgH and TCR rearrangements were detected in 7 of 8 and 7 of 7 Southern blot-negative cases, respectively. Our results suggested that PCR analysis was useful in diagnosing CTBL...
  30. ncbi request reprint Expression of chemokine receptor CXCR3 and its ligand, mig, in gastric and thyroid marginal zone lymphomas. Possible migration and autocrine mechanism
    Koichi Ohshima
    Department of Pathology, School of Medicine, Fukuoka University Nanakuma 7 45 1, Jonan ku, Fukuoka 814 0180, Japan
    Leuk Lymphoma 44:329-36. 2003
    ..We speculate that CXCR3 is associated with migration of lymphoma cells in low-grade MALT, and autocrine function in high-grade MALT, and not associated with any function in DL...
  31. ncbi request reprint Synergistic action of the microRNA-17 polycistron and Myc in aggressive cancer development
    Hiroyuki Tagawa
    Division of Molecular Medicine, Aichi Cancer Center, 1 1 Kanokoden, Chikusa ku, Nagoya, Aichi 464 8681, Japan
    Cancer Sci 98:1482-90. 2007
    ....
  32. ncbi request reprint Primary hepatic lymphoma 1 year after resection of hepatocellular carcinoma
    Atsushi Nonami
    First Department of Internal Medicine, Graduate School of Medicine, Kyushu University, Higashi ku, Fukuoka, Japan
    J Clin Oncol 24:5784-6. 2006
  33. ncbi request reprint Plasmacytoid dendritic cells prime alloreactive T cells to mediate graft-versus-host disease as antigen-presenting cells
    Motoko Koyama
    Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Science, Fukuoka, Japan
    Blood 113:2088-95. 2009
    ....
  34. doi request reprint Microenvironment of adult T-cell leukemia/lymphoma-associated nodal lesions
    Koichi Ohshima
    Department of Pathology, School of Medicine, Kurume University, Asahimati 67, Kurume, 830 0011, Japan
    Int J Hematol 99:240-8. 2014
    ..In this review, we discuss the pathological variations of microenvironments, which are important for clarification of the histological features associated with HTLV-I. ..
  35. ncbi request reprint Genome-wide array-based comparative genomic hybridization of natural killer cell lymphoma/leukemia: different genomic alteration patterns of aggressive NK-cell leukemia and extranodal Nk/T-cell lymphoma, nasal type
    Yasuhiro Nakashima
    Division of Molecular Medicine, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Aichi, Japan
    Genes Chromosomes Cancer 44:247-55. 2005
    ..3, 5q34-q35.3, 1p36.23-p36.33, 2p16.1-p16.3, 4q12, and 4q31.3-q32.1. Our results can be expected to provide further insights into the genetic basis of lymphomagenesis and the clinicopathologic features of NK-cell lymphomas/leukemias...
  36. doi request reprint Leukemic transformation of Langerhans cell sarcoma
    Kousuke Sumida
    Department of Hematology, Saga Prefectural Hospital Koseikan, 1 12 9, Mizugae, Saga 840 8571, Japan
    Int J Hematol 87:527-31. 2008
    ..These findings suggested leukemic transformation from Langerhans cell sarcoma. Leukemic transformation may be a clinical manifestation of advanced Langerhans cell sarcoma, and should be differentiated from acute myelogenous leukemia...
  37. ncbi request reprint Identification of subtype-specific genomic alterations in aggressive adult T-cell leukemia/lymphoma
    Aya Oshiro
    Division of Molecular Medicine, Aichi Cancer Center Institute, Nagoya, Aichi, Japan
    Blood 107:4500-7. 2006
    ..These results suggest that acute and lymphoma types are genomically distinct subtypes, and thus may develop tumors via distinct genetic pathways...
  38. ncbi request reprint [Clinical and molecular pathogenesis of follicular lymphoma]
    Kennosuke Karube
    Rinsho Ketsueki 49:159-64. 2008
  39. pmc IL-21 is expressed in Hodgkin lymphoma and activates STAT5: evidence that activated STAT5 is required for Hodgkin lymphomagenesis
    Ferenc A Scheeren
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Blood 111:4706-15. 2008
    ..Data from experiments using reporter assays and overexpression of constitutively active IKK2 support the hypothesis that the STAT5 and nuclear factor-kappaB (NF-kappaB) pathways collaborate in HL genesis...
  40. ncbi request reprint [Graves' disease with splenomegaly and pancytopenia, mimicking B-cell lymphoproliferative disease]
    Rie Ohtsuka
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
    Rinsho Ketsueki 49:104-8. 2008
    ..This clinical course suggests that polyclonal B-cell proliferation was caused by hyperthyroidism...
  41. ncbi request reprint Transgenic mice overexpressing murine thrombopoietin develop myelofibrosis and osteosclerosis
    Haruko Kakumitsu
    The First Department of Internal Medicine, Kyushu University Hospital, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Leuk Res 29:761-9. 2005
    ....