Tatsuo Kanda

Summary

Affiliation: Graduate School
Country: Japan

Publications

  1. ncbi request reprint Antiviral therapy for "difficult-to-treat" hepatitis C virus-infected patients
    Tatsuo Kanda
    Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, Japan Email
    Chin Med J (Engl) 126:4568-74. 2013
  2. pmc Treatment of hepatitis C virus infection in the future
    Tatsuo Kanda
    Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Clin Transl Med 2:9. 2013
  3. doi request reprint Long-term follow-up of patients with hepatitis B e antigen negative chronic hepatitis B
    Dan Bekku
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Gastroenterol Hepatol 26:122-8. 2011
  4. ncbi request reprint Analysis of the complete hepatitis B virus genome in patients with genotype C chronic hepatitis and hepatocellular carcinoma
    Kai Yu Zhang
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ward, Chiba City, Chiba 260 8670, Japan
    Cancer Sci 98:1921-9. 2007
  5. doi request reprint Interleukin-29 suppresses hepatitis A and C viral internal ribosomal entry site-mediated translation
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Chiba University Graduate School of Medicine, Chiba, Japan
    Viral Immunol 25:379-86. 2012
  6. doi request reprint Association between mutations in the core region of hepatitis C virus genotype 1 and hepatocellular carcinoma development
    Shingo Nakamoto
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ward, Chiba City, Chiba 260 8670, Japan
    J Hepatol 52:72-8. 2010
  7. doi request reprint Long-term cohort study of chronic hepatitis C according to interferon efficacy
    Daisuke Maruoka
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Gastroenterol Hepatol 27:291-9. 2012
  8. ncbi request reprint Inhibition of subgenomic hepatitis C virus RNA replication in HeLa cells
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Hepatogastroenterology 54:32-5. 2007
  9. pmc Peginterferon Alfa-2a plus ribavirin in Japanese patients infected with hepatitis C virus genotype 2 who failed previous interferon therapy
    Tatsuo Kanda
    Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Inohana, Chuo Ku, Chiba, Japan
    Int J Med Sci 10:43-9. 2013
  10. pmc Efficacy of lamivudine or entecavir on acute exacerbation of chronic hepatitis B
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Int J Med Sci 9:27-32. 2012

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Antiviral therapy for "difficult-to-treat" hepatitis C virus-infected patients
    Tatsuo Kanda
    Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, Japan Email
    Chin Med J (Engl) 126:4568-74. 2013
    ..To review the updated research on direct antiviral agents (DAAs)-including regimens for hepatitis C virus (HCV), and focus on "difficult-to-treat" HCV-infected patients...
  2. pmc Treatment of hepatitis C virus infection in the future
    Tatsuo Kanda
    Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Clin Transl Med 2:9. 2013
    ..In the near future, we might be using all-oral DAAs and interferon-free regimens for the treatment of HCV-infected patients, and these would be potent inhibitors of HCV and have less adverse events...
  3. doi request reprint Long-term follow-up of patients with hepatitis B e antigen negative chronic hepatitis B
    Dan Bekku
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Gastroenterol Hepatol 26:122-8. 2011
    ..We investigated the predictive factors for alanine aminotransferase (ALT) elevation, antiviral drug use, and hepatocellular carcinoma (HCC) occurrence in HBeAg-negative patients...
  4. ncbi request reprint Analysis of the complete hepatitis B virus genome in patients with genotype C chronic hepatitis and hepatocellular carcinoma
    Kai Yu Zhang
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ward, Chiba City, Chiba 260 8670, Japan
    Cancer Sci 98:1921-9. 2007
    ..8, and 1.4 times, respectively, in HepG2 cells. Substitutions and deletion of nucleotides of the HBV genome, especially the pre-S2 deletion and G1317A and T1341C/A/G mutations may be useful markers for predicting the development of HCC...
  5. doi request reprint Interleukin-29 suppresses hepatitis A and C viral internal ribosomal entry site-mediated translation
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Chiba University Graduate School of Medicine, Chiba, Japan
    Viral Immunol 25:379-86. 2012
    ..Combining IL-29 with IFN-α or amantadine resulted in stronger inhibition of HAV IRES activity. Our findings demonstrated a novel antiviral effect of IFNs-λ against HAV and HCV through the suppression of IRES-mediated translation...
  6. doi request reprint Association between mutations in the core region of hepatitis C virus genotype 1 and hepatocellular carcinoma development
    Shingo Nakamoto
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ward, Chiba City, Chiba 260 8670, Japan
    J Hepatol 52:72-8. 2010
    ..To determine whether amino acid mutations in the core region of hepatitis C virus (HCV) genotype 1 are associated with response to interferon (IFN) therapy and development of hepatocellular carcinoma (HCC)...
  7. doi request reprint Long-term cohort study of chronic hepatitis C according to interferon efficacy
    Daisuke Maruoka
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Gastroenterol Hepatol 27:291-9. 2012
    ..We investigated the prognosis of patients with C-viral chronic liver disease (C-CLD) according to the efficacy of interferon (IFN) therapy in a long-term retrospective cohort study...
  8. ncbi request reprint Inhibition of subgenomic hepatitis C virus RNA replication in HeLa cells
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Hepatogastroenterology 54:32-5. 2007
    ..The aim of this study was to evaluate the effect of interferon or ribavirin treatment on subgenomic HCV RNA replication in 'non-hepatic' HeLa cells...
  9. pmc Peginterferon Alfa-2a plus ribavirin in Japanese patients infected with hepatitis C virus genotype 2 who failed previous interferon therapy
    Tatsuo Kanda
    Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Inohana, Chuo Ku, Chiba, Japan
    Int J Med Sci 10:43-9. 2013
    ..Attention should be paid to certain patients with unique features. Selection of patients according to their previous treatment could lead to optimal therapy in HCV genotype 2 treatment-experienced patients...
  10. pmc Efficacy of lamivudine or entecavir on acute exacerbation of chronic hepatitis B
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Int J Med Sci 9:27-32. 2012
    ..We compared the effects of lamivudine (LAM) with those of entecavir (ETV) treatments in acute exacerbation of chronic hepatitis B with 500 IU/L or higher alanine aminotransferase (ALT) levels...
  11. pmc Hepatic STAT1-nuclear translocation and interleukin 28B polymorphisms predict treatment outcomes in hepatitis C virus genotype 1-infected patients
    Tatsuo Miyamura
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    PLoS ONE 6:e28617. 2011
    ....
  12. pmc Roles of ITPA and IL28B genotypes in chronic hepatitis C patients treated with peginterferon plus ribavirin
    Tatsuo Miyamura
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    Viruses 4:1264-78. 2012
    ..Use of the combination of these two genotypes could lead to safe and effective treatment of chronic hepatitis C patients...
  13. doi request reprint Evolution of hepatitis B genotype C viral quasi-species during hepatitis B e antigen seroconversion
    Shuang Wu
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Hepatol 54:19-25. 2011
    ..Although the evolution of viral quasi-species may be related to the pathological status of disease, little is known about this phenomenon in hepatitis B, particularly with respect to hepatitis B e antigen (HBeAg) seroconversion...
  14. doi request reprint Hepatitis B virus e antigen downregulates cytokine production in human hepatoma cell lines
    Shuang Wu
    Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, Chiba, Japan
    Viral Immunol 23:467-76. 2010
    ..HBeAg might modify disease progression by inhibiting inflammatory cytokine and IFN gene expression, while simultaneously suppressing NF-κB-signaling- and IFNß-promoter activation...
  15. pmc Adherence to medication is a more important contributor to viral breakthrough in chronic hepatitis B patients treated with entecavir than in those with Lamivudine
    Hidehiro Kamezaki
    Departments of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Int J Med Sci 10:567-74. 2013
    ..0% of ETV- and 94.1% of LAM-treated patients with viral breakthrough (P=0.047). Viral breakthrough associated with poor adherence could be a more important issue in the treatment with especially stronger NAs, such as ETV...
  16. doi request reprint Hepatitis B virus e antigen physically associates with receptor-interacting serine/threonine protein kinase 2 and regulates IL-6 gene expression
    Shuang Wu
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Infect Dis 206:415-20. 2012
    ....
  17. pmc Inhibitory effects on HAV IRES-mediated translation and replication by a combination of amantadine and interferon-alpha
    Lingli Yang
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Virol J 7:212. 2010
    ..In conclusion, amantadine, in combination of IFN-alpha, might have a beneficial effect in some patients with acute hepatitis A...
  18. doi request reprint Response to peginterferon-alfa 2b and ribavirin in Japanese patients with chronic hepatitis C genotype 2
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Dig Dis Sci 56:3335-42. 2011
    ..The current standard treatment for patients infected with hepatitis C virus (HCV) of genotype 2 is the combination of peginterferon (PEG-IFN) plus ribavirin (RBV) for 24 weeks...
  19. pmc Efficacy of lamivudine or entecavir against virological rebound after achieving HBV DNA negativity in chronic hepatitis B patients
    Tomoo Miyauchi
    Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Chiba 260 8677, Japan
    Int J Med Sci 10:647-52. 2013
    ..In contrast, LAM could not inhibit HBV replication even if HBV negativity was achieved in the early phase. Attention should be paid to these features in clinical practice...
  20. doi request reprint Quantification of hepatitis C amino acid substitutions 70 and 91 in the core coding region by real-time amplification refractory mutation system reverse transcription-polymerase chain reaction
    Shingo Nakamoto
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba, Japan
    Scand J Gastroenterol 44:872-7. 2009
    ..The purpose of this study was to establish real-time amplification refractory mutation system (ARMS) reverse transcription (RT)-polymerase chain reaction (PCR) assays for easy detection of these HCV mutations...
  21. doi request reprint Occurrence of hepatocellular carcinoma was not a rare event during and immediately after antiviral treatment in Japanese HCV-positive patients
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba, Japan
    Oncology 80:366-72. 2011
    ..Clinicians should regularly check for the possible development of HCC even in chronic hepatitis C patients under treatment...
  22. ncbi request reprint Different effects of three interferons L on Toll-like receptor-related gene expression in HepG2 cells
    Tatsuo Kanda
    Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan Electronic address
    Cytokine 64:577-83. 2013
    ..IFNL is a powerful modulator of innate immune response and it is supposed that the 3 IFNLs may play different roles in the antiviral activity against HBV and HCV. ..
  23. ncbi request reprint Analysis of genes upregulated by the demethylating agent 5-aza-2'-deoxycytidine in gastric cancer cell lines
    Rintaro Mikata
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Int J Cancer 119:1616-22. 2006
    ..In particular, the suppression of BCL2L10, which could induce apoptosis and inhibit proliferation of cancer cells, might be one of the underlying mechanisms for gastric carcinogenesis...
  24. ncbi request reprint Analysis of the complete hepatitis B virus genome in patients with genotype C chronic hepatitis in relation to HBeAg and anti-HBe
    Kaiyu Zhang
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Med Virol 79:683-93. 2007
    ..This whole genome analysis of HBV chronic carriers suggested that the nucleotide substitutions and deletions in HBV were closely associated with the pathogenesis of chronic HBV infection...
  25. ncbi request reprint Evaluation of clinical usefulness of second-generation HCV core antigen assay: comparison with COBAS AMPLICOR HCV MONITOR assay version 2.0
    Osamu Yokosuka
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Liver Int 25:1136-41. 2005
    ..Hepatitis C virus (HCV) is an important etiologic agent for chronic liver diseases...
  26. ncbi request reprint Body mass index in Japanese patients with autoimmune liver disease: overweight patients with primary biliary cirrhosis tend to be asymptomatic
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Japan
    Hepatogastroenterology 54:1758-60. 2007
    ..The aim of this study was to investigate the effects of being overweight on autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) patients...
  27. doi request reprint Risk of hepatocellular carcinoma in patients with chronic hepatitis B virus infection
    Kenichi Ito
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Scand J Gastroenterol 45:243-9. 2010
    ..To determine the risk factors for the occurrence of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV) infection...
  28. doi request reprint Inhibition of cell viability by human IFN-β is mediated by microRNA-431
    Takeshi Tanaka
    Department of Environmental Biochemistry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba 260 8670, Japan
    Int J Oncol 40:1470-6. 2012
    ..Based on these results, we propose that, in RSa cells, HuIFN-β-induced miR-431 expression may down-regulate IGF1R and IRS2 expression, and consequently inhibit cell proliferation by suppressing the MAPK pathway...
  29. ncbi request reprint Emergence of entecavir-resistant mutations in nucleos(t)ide-naive Japanese patients infected with hepatitis B virus: virological breakthrough is also dependent on adherence to medication
    Hidehiro Kamezaki
    Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Scand J Gastroenterol 46:1111-7. 2011
    ....
  30. doi request reprint Quantification of hepatitis B surface antigen can help predict spontaneous hepatitis B surface antigen seroclearance
    Makoto Arai
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Eur J Gastroenterol Hepatol 24:414-8. 2012
    ..The aim of this study was to investigate the clinical course of spontaneous HBsAg seroclearance and the factors predicting it...
  31. ncbi request reprint Sequential gene expression changes in cancer cell lines after treatment with the demethylation agent 5-Aza-2'-deoxycytidine
    Makoto Arai
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Cancer 106:2514-25. 2006
    ....
  32. ncbi request reprint Enhanced sensitivity of human hepatoma cells to 5-fluorouracil by small interfering RNA targeting Bcl-2
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Japan
    DNA Cell Biol 24:805-9. 2005
    ..5 +/- 0.86)%, respectively. The Bcl-2 siRNA prior to 5-FU treatment group showed the strongest effect of inducing apoptosis. In conclusion, the combination Bcl-2 siRNA and 5-FU might represent a new therapeutic option for HCC...
  33. doi request reprint Initial virological response and viral mutation with adefovir dipivoxil added to ongoing Lamivudine therapy in Lamivudine-resistant chronic hepatitis B
    Shuang Wu
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ward, Chiba City, Chiba, 260 8670, Japan
    Dig Dis Sci 56:1207-14. 2011
    ..Initial virological response (IVR) has been reported to be an important factor in relation to the development of ADV-resistance...
  34. ncbi request reprint Lower incidence of hepatic failure than hepatocellular carcinoma in Japanese patients with chronic hepatitis C
    Fumio Imazeki
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Liver Int 25:772-8. 2005
    ..We investigated the status in Japan in a retrospective cohort study...
  35. doi request reprint Pfetin as a prognostic biomarker for gastrointestinal stromal tumor: validation study in multiple clinical facilities
    Daisuke Kubota
    Division of Pharmacoproteomics, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Clin Oncol 41:1194-202. 2011
    ..There is no biomarker predicting metastasis and/or recurrence of gastrointestinal stromal tumor though imatinib mesylate can improve recurrence-free survival...
  36. ncbi request reprint 5-aza-2'-deoxycytidine sensitizes hepatoma and pancreatic cancer cell lines
    Tatsuo Kanda
    The Department of Medicine and Clinical Oncology, Graduate School of Medicine Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 0856, Japan
    Oncol Rep 14:975-9. 2005
    ....
  37. ncbi request reprint Occurrence of autoimmune hepatitis during the course of primary biliary cirrhosis: report of two cases
    Tatsuo Kanda
    First Department of Medicine, Chiba University School of Medicine, Chiba, Japan
    Dig Dis Sci 51:45-6. 2006
  38. doi request reprint Lipopolysaccharide blocks induction of unfolded protein response in human hepatoma cell lines
    Xia Jiang
    Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Chuo Ku, Chiba, Japan
    Immunol Lett 152:8-15. 2013
    ..These data suggest that UPR downregulation could be a collateral effect of the LPS treatment. We speculate that UPR is an important factor of hepatic cell damage induced by an innate immune response...
  39. pmc Analysis of 5' nontranslated region of hepatitis A viral RNA genotype I from South Korea: comparison with disease severities
    Tatsuo Kanda
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    PLoS ONE 5:e15139. 2010
    ..In conclusion, HAV 5'NTR subgenotype IA from Korea had relatively high homology to Japanese sequences previously reported from Japan, and this region would be considered one of the antiviral targets. Further studies will be needed...
  40. pmc Platelet count and sustained virological response in hepatitis C treatment
    Tatsuo Kanda
    Tatsuo Kanda, Tatsuo Miyamura, Daisuke Maruoka, Shuang Wu, Shingo Nakamoto, Makoto Arai, Keiichi Fujiwara, Fumio Imazeki, Osamu Yokosuka, Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba 260 8677, Japan
    World J Hepatol 5:182-8. 2013
    ..To examine the epidemiological data, hematological safety and treatment responses of peginterferon-alpha 2a plus ribavirin therapy for hepatitis C...
  41. pmc Ultra-deep sequencing analysis of the hepatitis A virus 5'-untranslated region among cases of the same outbreak from a single source
    Shuang Wu
    1 Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    Int J Med Sci 11:60-4. 2014
    ..It might be more interesting to perform ultra-deep sequencing of full length HAV genome in order to reveal possible unknown genomic determinants associated with disease severity. Further studies will be needed. ..
  42. pmc Alanine aminotransferase elevation during peginterferon alpha-2a or alpha-2b plus ribavirin treatment
    Masato Nakamura
    Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Int J Med Sci 10:1015-21. 2013
    ..In conclusion, clinicians should pay attention to possible ALT elevation during the treatment of chronic hepatitis C patients. ..
  43. ncbi request reprint Hepatitis C virus protease inhibitor-resistance mutations: our experience and review
    Shuang Wu
    Shuang Wu, Tatsuo Kanda, Shingo Nakamoto, Osamu Yokosuka, Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Chiba 260 8677, Japan
    World J Gastroenterol 19:8940-8. 2013
    ..Here, we reviewed the literature on resistance variants of HCV protease inhibitors in treatment naïve patients with chronic HCV genotype 1, as well as our experience. ..
  44. doi request reprint Downregulation of microRNA-431 by human interferon-β inhibits viability of medulloblastoma and glioblastoma cells via upregulation of SOCS6
    Takeshi Tanaka
    Department of Molecular Oncology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Int J Oncol 44:1685-90. 2014
    ..We propose that, in medulloblastoma and glioblastoma cells, HuIFN-β decreases miR-431 expression and upregulates SOCS6 expression, and consequently inhibit cell proliferation by suppressing the JAK-STAT signaling pathway. ..
  45. ncbi request reprint Suppression of La Antigen Exerts Potential Antiviral Effects against Hepatitis A Virus
    Xia Jiang
    Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Chiba, Japan
    PLoS ONE 9:e101993. 2014
    ..The aim of the present study is to evaluate the impact of La, one of the cellular proteins, on HAV IRES-mediated translation and HAV replication...
  46. doi request reprint Nuclear receptor mRNA expression by HBV in human hepatoblastoma cell lines
    Shuang Wu
    Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8677, Japan
    Cancer Lett 312:33-42. 2011
    ..2.15 compared to HepG2. These results suggest that HBV affects NRs and their related signal transduction, and that they play important roles in viral replication and HBV-related hepatocarcinogenesis...
  47. ncbi request reprint State of hepatitis C viral replication enhances activation of NF-kB- and AP-1-signaling induced by hepatitis B virus X
    Tatsuo Kanda
    Safety and Health Organization, Chiba University, 1 33 Yayoicho, Inage Ku, Chiba 263 8522, Japan
    Cancer Lett 234:143-8. 2006
    ..HBx protein might play an important role in HCV-related hepatocarcinogenesis...
  48. doi request reprint Simple assay based on restriction fragment length polymorphism associated with IL28B in chronic hepatitis C patients
    Shingo Nakamoto
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Inohana, Chuo Ku, Chiba, Japan
    Scand J Gastroenterol 46:955-61. 2011
    ..The purpose of the study was to establish methods for determining the SNP rs8099917 associated with IL28B, which might be useful for further research of the treatment of HCV...
  49. ncbi request reprint Possible widespread presence of hepatitis A virus subgenotype IIIA in Japan: Recent trend of hepatitis A causing acute liver failure
    Tatsuo Miyamura
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan
    Hepatol Res 42:248-53. 2012
    ..Conclusions:  Fujiwara et al. reported a frequency of HAV subgenotype IIIA of only 2.1% in Japan. We conclude that HAV subgenotype IIIA might be widespread in our country...
  50. doi request reprint Prevalence of diabetes mellitus and insulin resistance in patients with chronic hepatitis C: comparison with hepatitis B virus-infected and hepatitis C virus-cleared patients
    Fumio Imazeki
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Liver Int 28:355-62. 2008
    ....
  51. pmc Pegylated interferon-alfa-2a monotherapy in patients infected with HCV genotype 2 and importance of rapid virological response
    Reiko Etoh
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    BMC Res Notes 4:316. 2011
    ..abstract:..
  52. ncbi request reprint Acute-onset autoimmune hepatitis resembling acute hepatitis: a case report and review of reported cases
    Tatsuo Kanda
    First Department of Internal Medicine, Chiba University School of Medicine, Chiba, Japan
    Hepatogastroenterology 52:1233-5. 2005
    ..This is the third such case report in the literature...
  53. ncbi request reprint Knockdown of receptor-interacting serine/threonine protein kinase-2 (RIPK2) affects EMT-associated gene expression in human hepatoma cells
    Shuang Wu
    Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, Chuo Ku, Chiba, Japan
    Anticancer Res 32:3775-83. 2012
    ..We investigated the effects of RIPK2 knockdown in human hepatoma cells on epithelial-to-mesenchymal transition (EMT)-associated gene expression...
  54. ncbi request reprint Involvement of androgen receptor and glucose-regulated protein 78kDa in human hepatocarcinogenesis
    Xia Jiang
    Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Exp Cell Res 323:326-36. 2014
    ..AR seems a co-regulator of GRP78 especially in earlier-stage HCC. AR plays a critical role in controlling ER-stress, providing new therapeutic options against HCC. ..
  55. ncbi request reprint Amantadine inhibits hepatitis A virus internal ribosomal entry site-mediated translation in human hepatoma cells
    Tatsuo Kanda
    Safety and Health Organization, Chiba University, 1 33 Yayoicho, Inage Ku, Chiba 263 8522, Japan
    Biochem Biophys Res Commun 331:621-9. 2005
    ..Immunoblot analysis revealed that amantadine had no effect on PKR and on IFN-regulatory factor-1 (IRF-1) expression. These findings demonstrated a novel antiviral effect of amantadine against HAV with or without HCV infection...
  56. doi request reprint Epigenetic silencing of microRNA-373 plays an important role in regulating cell proliferation in colon cancer
    Takeshi Tanaka
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Oncol Rep 26:1329-35. 2011
    ..Based on these results, we conclude that expression of hsa-miR-373 is down-regulated by aberrant methylation in colon cancer and that this miRNA may function by regulating expression of the oncogene RAB22A...
  57. pmc Prevalence of hepatitis C virus subgenotypes 1a and 1b in Japanese patients: ultra-deep sequencing analysis of HCV NS5B genotype-specific region
    Shuang Wu
    Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Chiba, Japan
    PLoS ONE 8:e73615. 2013
    ..In Japan, almost all of HCV genotype 1 belongs to subgenotype 1b...
  58. pmc Acute liver failure associated with propylthiouracil in a pregnant 26-year-old woman
    Tatsuo Miyamura
    Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Chiba, Japan
    Case Rep Gastroenterol 7:240-4. 2013
    ..She was successfully treated without liver transplantation. Attention should be paid to the possible occurrence of propylthiouracil-induced hepatotoxicity even during the first trimester of pregnancy. ..
  59. ncbi request reprint Adjuvant therapy with imatinib mesylate after resection of primary high-risk gastrointestinal stromal tumors in Japanese patients
    Tatsuo Kanda
    Department of Surgery, Niigata University Medical and Dental Hospital, 1 754 Asahimachi dori, Chuo Ku, Niigata, 951 8520, Japan
    Int J Clin Oncol 18:38-45. 2013
    ..There are no data concerning the efficacy and safety of postoperative adjuvant therapy with imatinib for Japanese or East Asian patients with GIST...
  60. pmc Acute liver failure in an antimitochondrial antibody-positive 63-year-old man
    Toru Wakamatsu
    Department of Medicine and Clinical Oncology, Chiba University Graduate School of Medicine, Chiba, Japan
    Case Rep Gastroenterol 6:394-9. 2012
    ....
  61. ncbi request reprint Hepatitis C Virus nonstructural 5A protein inhibits lipopolysaccharide-mediated apoptosis of hepatocytes by decreasing expression of Toll-like receptor 4
    Ryo Tamura
    Department of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, Japan
    J Infect Dis 204:793-801. 2011
    ..The aim of this study was to assess the effects of HCV NS5A on apoptosis induced by Toll-like receptor (TLR) 4 ligand, lipopolysaccharide (LPS)...
  62. pmc No correlation between PNPLA3 rs738409 genotype and fatty liver and hepatic cirrhosis in Japanese patients with HCV
    Masato Nakamura
    Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, Chiba, Japan
    PLoS ONE 8:e81312. 2013
    ..Recent reports have suggested that PNPLA3, IL28B and TLR4-associated single nucleotide polymorphisms (SNPs) may have an impact on hepatic steatosis or fibrosis in patients with chronic HCV infection...