Hajime Isomoto

Summary

Affiliation: Graduate School
Country: Japan

Publications

  1. doi request reprint Background coloration of squamous epithelium in esophago-pharyngeal squamous cell carcinoma: what causes the color change?
    Hitomi Minami
    Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Nagasaki, Japan
    PLoS ONE 9:e85553. 2014
  2. pmc Immune and Inflammatory Responses in GERD and Lansoprazole
    Hajime Isomoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Clin Biochem Nutr 41:84-91. 2007
  3. pmc Endoscopic submucosal dissection in the era of proton pump inhibitors
    Hajime Isomoto
    Department of Endoscopy, Nagasaki University Hospital of Medicine and Dentistry, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Clin Biochem Nutr 44:205-11. 2009
  4. pmc Epiploic appendagitis in a 27-year-old man
    Ryohei Uehara
    Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Nagasaki, Japan
    Med Sci Monit 17:CS113-5. 2011
  5. pmc Peyer's Patches in the Terminal Ileum in Ulcerative Colitis: Magnifying Endoscopic Findings
    Hiroyuki Ishii
    Second Department of Internal Medicine, Nagasaki University Hospital, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Clin Biochem Nutr 46:111-8. 2010
  6. pmc Endocytoscopic findings of lymphomas of the stomach
    Hajime Isomoto
    Department of Gastroenterology and Hepatology, Nagasaki University Hospital, 1 7 1 Sakamoto, Nagasaki 852 8102, Japan
    BMC Gastroenterol 13:174. 2013
  7. doi request reprint Interweaving microRNAs and proinflammatory cytokines in gastric mucosa with reference to H. pylori infection
    Hajime Isomoto
    Department of Gastroenterology and Hepatology, Nagasaki University Hospital, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Clin Immunol 32:290-9. 2012
  8. doi request reprint Clinicopathological factors associated with clinical outcomes of endoscopic submucosal dissection for colorectal epithelial neoplasms
    H Isomoto
    Department of Endoscopy, Nagasaki University Hospital, Sakamoto, Nagasaki, Japan
    Endoscopy 41:679-83. 2009
  9. ncbi request reprint Multiple lymphomatous polyposis of the colon originating from T-cells: a case report
    H Isomoto
    Department of Endoscopy, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8102, Japan
    Dig Liver Dis 36:218-21. 2004
  10. doi request reprint Epigenetic alterations in cholangiocarcinoma-sustained IL-6/STAT3 signaling in cholangio- carcinoma due to SOCS3 epigenetic silencing
    Hajime Isomoto
    Department of Endoscopy, Nagasaki University Hospital of Medicine and Dentistry, Nagasaki, Japan
    Digestion 79:2-8. 2009

Collaborators

Detail Information

Publications115 found, 100 shown here

  1. doi request reprint Background coloration of squamous epithelium in esophago-pharyngeal squamous cell carcinoma: what causes the color change?
    Hitomi Minami
    Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Nagasaki, Japan
    PLoS ONE 9:e85553. 2014
    ..This study aims to clarify the cause of background coloration in the epithelia between each dilated intra papillary capillary loop in esophago-pharyngeal squamous cell carcinoma...
  2. pmc Immune and Inflammatory Responses in GERD and Lansoprazole
    Hajime Isomoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Clin Biochem Nutr 41:84-91. 2007
    ..This may occur in part through an anti-inflammatory action of proton pump inhibitors beyond gastric acid inhibition...
  3. pmc Endoscopic submucosal dissection in the era of proton pump inhibitors
    Hajime Isomoto
    Department of Endoscopy, Nagasaki University Hospital of Medicine and Dentistry, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Clin Biochem Nutr 44:205-11. 2009
    ..Bleeding during ESD can be managed with coagulation forceps, and postoperative bleeding may be reduced with routine use of the stronger acid suppressant, proton pump inhibitors...
  4. pmc Epiploic appendagitis in a 27-year-old man
    Ryohei Uehara
    Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Nagasaki, Japan
    Med Sci Monit 17:CS113-5. 2011
    ..Epiploic appendagitis is self-limited without surgery, and it is imperative for clinicians to be familiar with this entity...
  5. pmc Peyer's Patches in the Terminal Ileum in Ulcerative Colitis: Magnifying Endoscopic Findings
    Hiroyuki Ishii
    Second Department of Internal Medicine, Nagasaki University Hospital, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Clin Biochem Nutr 46:111-8. 2010
    ..Similar to Crohn's disease patients, UC patients commonly had abnormalities in the FAE on PPs' domes and the surrounding villi on magnifying endoscopy...
  6. pmc Endocytoscopic findings of lymphomas of the stomach
    Hajime Isomoto
    Department of Gastroenterology and Hepatology, Nagasaki University Hospital, 1 7 1 Sakamoto, Nagasaki 852 8102, Japan
    BMC Gastroenterol 13:174. 2013
    ..The gastric lesions of various lymphomas were observed at the cellular level using endocytoscopy...
  7. doi request reprint Interweaving microRNAs and proinflammatory cytokines in gastric mucosa with reference to H. pylori infection
    Hajime Isomoto
    Department of Gastroenterology and Hepatology, Nagasaki University Hospital, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Clin Immunol 32:290-9. 2012
    ..pylori-negative gastric mucosa. Underscoring the causal association between miRNAs and proinflammatory cytokines may provide insights into the pathogenesis of H. pylori-associated gastritis linking to gastric carcinogenesis...
  8. doi request reprint Clinicopathological factors associated with clinical outcomes of endoscopic submucosal dissection for colorectal epithelial neoplasms
    H Isomoto
    Department of Endoscopy, Nagasaki University Hospital, Sakamoto, Nagasaki, Japan
    Endoscopy 41:679-83. 2009
    ..We sought to unravel the clinicopathological factors associated with the clinical outcomes of ESD for colorectal epithelial neoplasms in a large series...
  9. ncbi request reprint Multiple lymphomatous polyposis of the colon originating from T-cells: a case report
    H Isomoto
    Department of Endoscopy, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8102, Japan
    Dig Liver Dis 36:218-21. 2004
    ..The patient was treated with combined chemotherapy, leading to complete resolution of the lesions...
  10. doi request reprint Epigenetic alterations in cholangiocarcinoma-sustained IL-6/STAT3 signaling in cholangio- carcinoma due to SOCS3 epigenetic silencing
    Hajime Isomoto
    Department of Endoscopy, Nagasaki University Hospital of Medicine and Dentistry, Nagasaki, Japan
    Digestion 79:2-8. 2009
    ..Indeed, SOCS3 epigenetic silencing is responsible for sustained IL-6/STAT3 signaling in CCA. These findings provide new perspectives for epigenetic therapy to restore SOCS3 in this cancer...
  11. ncbi request reprint Pure red cell aplasia associated with parvovirus B19 infection in a patient with ulcerative colitis
    Hajime Isomoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Dig Dis Sci 48:2104-7. 2003
    ..In conclusion, Chronic or acute blood loss in UC associated with enhanced red cell turnover might be a risk factor for PRCA when affected patients contract parvovirus B19 infection...
  12. doi request reprint Clinical outcomes of endoscopic submucosal dissection in elderly patients with early gastric cancer
    Hajime Isomoto
    Second Department of Internal Medicine, Nagasaki University Hospital, Sakamoto, Nagasaki, Japan
    Eur J Gastroenterol Hepatol 22:311-7. 2010
    ..The number of elderly patients (more than 75 years old) with early gastric cancer (EGC) has been steadily increasing. We sought to assess clinical outcomes of ESD for EGC in elderly...
  13. ncbi request reprint Expression of CXC receptor 1 and 2 in esophageal mucosa of patients with reflux esophagitis
    Hajime Isomoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    World J Gastroenterol 11:1793-7. 2005
    ..The purpose of this study was to determine CXCR-1 and -2 messenger RNA expression levels in RE...
  14. ncbi request reprint Impact of Helicobacter pylori infection on ghrelin and various neuroendocrine hormones in plasma
    Hajime Isomoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki, Japan
    World J Gastroenterol 11:1644-8. 2005
    ..We sought to elucidate the relationship between ghrelin and various peptides in plasma, with special reference to H pylori...
  15. ncbi request reprint Sofalcone, a mucoprotective agent, increases the cure rate of Helicobacter pylori infection when combined with rabeprazole, amoxicillin and clarithromycin
    Hajime Isomoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    World J Gastroenterol 11:1629-33. 2005
    ..We determined the therapeutic effects of sofalcone and polaprezinc when combined with rabeprazole, amoxicillin and clarithromycin for Helicobacter pylori infection...
  16. ncbi request reprint Effect of Helicobacter pylori eradication on gastric hyperplastic polyposis in Cowden's disease
    Hajime Isomoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine 1 7 1 Sakamoto, Nagasaki, Japan
    World J Gastroenterol 11:1567-9. 2005
    ..We recommend eradication treatment for CD patients with gastric hyperplastic polyps and the infection, as the occurrence of gastric carcinoma among hyperplastic polyps has been described...
  17. ncbi request reprint Endoscopic identification of Peyer's patches of the terminal ileum in a patient with Crohn's disease
    Hiroshi Ishimoto
    Department of Internal Medicine, National Nagasaki Medical Center, 2 1001 Kubara, Omura, Nagasaki 856 8562, Japan
    World J Gastroenterol 10:2767-8. 2004
    ..Scanning electron microscopy revealed the presence of M cells, confirming that the area corresponded to Peyer's patches. Peyer's patches by magnifying endoscopy and electron microscopy may provide insights into the pathogenesis of CD...
  18. ncbi request reprint Circulating ghrelin levels in patients with various upper gastrointestinal diseases
    Hajime Isomoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Dig Dis Sci 50:833-8. 2005
    ..Further investigation is warranted to unravel the mechanisms of the high circulating ghrelin levels in certain upper gastrointestinal diseases...
  19. ncbi request reprint Endoscope disinfection using chlorine dioxide in an automated washer-disinfector
    H Isomoto
    Department of Endoscopy, Nagasaki University School of Medicine, Sakamoto, Nagasaki, Japan
    J Hosp Infect 63:298-305. 2006
    ..The use of automated reprocessors with compatibility to chlorine dioxide, coupled with thorough pre-cleaning, can offer effective, faster and less problematic endoscopic disinfection...
  20. ncbi request reprint Usefulness of the immunological rapid urease test for detection of Helicobacter pylori in patients who are reluctant to undergo endoscopic biopsies
    Hajime Isomoto
    Department of Endoscopy, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Dig Dis Sci 51:2302-5. 2006
    ..The results of IRUT completely agreed with those of urea breath test following anti-H. pylori therapy. The IRUT has acceptable diagnostic performance in such cohorts reluctant to undergo endoscopic biopsies due to the risk of bleeding...
  21. ncbi request reprint Heat-directed suicide gene therapy mediated by heat shock protein promoter for gastric cancer
    Hajime Isomoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852 8501, Japan
    Oncol Rep 15:629-35. 2006
    ..We conclude that the combination of suicide gene therapy with hyperthermia can provide a promising treatment modality for advanced gastric cancer...
  22. ncbi request reprint CXC receptor 1 is overexpressed in endoscopy-negative gastroesophageal reflux disease
    Hajime Isomoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852 8501, Japan
    Scand J Gastroenterol 40:231-2. 2005
  23. ncbi request reprint Interleukin-8 levels in esophageal mucosa and long-term clinical outcome of patients with reflux esophagitis
    Hajime Isomoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Scand J Gastroenterol 42:410-1. 2007
  24. pmc Management of esophageal stricture after complete circular endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma
    Hajime Isomoto
    Department of Endoscopy, Nagasaki University Hospital, 1 7 1 Sakamoto, Nagasaki 852 8102, Japan
    BMC Gastroenterol 11:46. 2011
    ..We examined the effectiveness of systemic steroid administration for control of postprocedural esophageal stricture after complete circular ESD...
  25. ncbi request reprint High concentrations of human beta-defensin 2 in gastric juice of patients with Helicobacter pylori infection
    Hajime Isomoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    World J Gastroenterol 11:4782-7. 2005
    ..Unlike HBD-1, the HBD-2 expression is augmented by Helicobacter pylori (H pylori). We sought to determine HBD-1 and HBD-2 concentrations in gastric juice during H pylori infection...
  26. ncbi request reprint Interleukin 8 and 1beta and RANTES levels in esophageal mucosa predict recurrence of endoscopy-negative gastroesophageal reflux disease
    Hajime Isomoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Sakamoto, Nagasaki, Japan
    Hepatogastroenterology 55:482-5. 2008
    ..Proinflammatory cytokines and chemokines play a role in the pathogenesis of various conditions including GERD...
  27. doi request reprint Magnified endoscopic findings of gastric low-grade mucosa-associated lymphoid tissue lymphoma
    H Isomoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Endoscopy 40:225-8. 2008
  28. doi request reprint Endoscopic submucosal dissection for early gastric cancer: a large-scale feasibility study
    H Isomoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Gut 58:331-6. 2009
    ..Complications were assessed, and factors related to each were analysed statistically. The overall and disease-free survival rates were estimated...
  29. ncbi request reprint Mucosal concentrations of proinflammatory cytokines and chemokines at gastric cardia: implication of Helicobacter pylori infection and gastroesophageal reflux
    Hajime Isomoto
    Department of Endoscopy, Nagasaki University School of Medicine, Nagasaki, Japan
    Am J Gastroenterol 99:1063-8. 2004
    ..Little is known about the profile of proinflammatory cytokines and chemokines in the pathogenesis of carditis...
  30. ncbi request reprint Concentrations of alpha- and beta-defensins in gastric juice of patients with various gastroduodenal diseases
    Yoshito Nishi
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan
    World J Gastroenterol 11:99-103. 2005
    ..To determine the concentration of alpha- and beta-defensins in gastric juice of patients with various gastroduodenal diseases...
  31. ncbi request reprint Elevated levels of chemokines in esophageal mucosa of patients with reflux esophagitis
    Hajime Isomoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Sakamoto, Nagasaki, Japan
    Am J Gastroenterol 98:551-6. 2003
    ..Chemokines play a key role in the pathogenesis of various inflammatory conditions. However, there is little information on their profile in reflux esophagitis (RE). We sought to study esophageal mucosa levels of chemokines in RE...
  32. ncbi request reprint Successful management of cap polyposis with eradication of Helicobacter pylori relapsing 15 years after remission on steroid therapy
    Fuminao Takeshima
    Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Japan
    Intern Med 51:435-9. 2012
    ..We present a case of cap polyposis relapsing 15 years after remission with steroid therapy, and that was improved by H. pylori eradication therapy...
  33. ncbi request reprint Lafutidine, a novel histamine H2-receptor antagonist, vs lansoprazole in combination with amoxicillin and clarithromycin for eradication of Helicobacter pylori
    Hajime Isomoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki, Japan
    Helicobacter 8:111-9. 2003
    ..Lafutidine is a novel potent H2 receptor antagonist with gastroprotective activities such as enhancement of gastric mucosal blood flow...
  34. doi request reprint Usefulness of oral prednisolone in the treatment of esophageal stricture after endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma
    Naoyuki Yamaguchi
    Department of Endoscopy, Nagasaki University Hospital, Nagasaki, Japan
    Gastrointest Endosc 73:1115-21. 2011
    ..However, postprocedure stricture is common after ESD for extensive tumors, and multiple endoscopic balloon dilation (EBD) is required for recalcitrant cases...
  35. ncbi request reprint Clinical implications of antimitochondrial antibodies in type 1 autoimmune hepatitis: a longitudinal study
    Shiho Mishima
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852 8501, Japan
    Hepatogastroenterology 55:221-7. 2008
    ..However, antimitochondrial antibodies (AMA) and bile duct changes, which are the characteristics of primary biliary cirrhosis (PBC), can be detected in AIH patients...
  36. ncbi request reprint Evaluation of newly developed ELISA using "MESACUP-2 test mitochondrial M2" kit for the diagnosis of primary biliary cirrhosis
    Yoshiko Kadokawa
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Clin Biochem 36:203-10. 2003
    ..The aim of this study was to evaluate the clinical utility of this newly developed ELISA for the diagnosis of primary biliary cirrhosis (PBC)...
  37. ncbi request reprint Autoimmune pancreatitis with extreme elevation of DUPAN-2
    Shiho Mishima
    Department of Internal Medicine, Nagasaki Municipal Hospital, Nagasaki, Japan
    Intern Med 46:377-81. 2007
    ..Computed tomography showed significant regression in the size of the pancreas, and the stenosis of the main pancreatic duct was improved on ERCP. The serum level of DUPAN-2 was also markedly decreased after the treatment...
  38. ncbi request reprint Impact of endoscopically minimal involvement on IL-8 mRNA expression in esophageal mucosa of patients with non-erosive reflux disease
    Yusei Kanazawa
    Second Department of Internal Medicine, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan
    World J Gastroenterol 9:2801-4. 2003
    ..The purpose of this study was to determine IL-8 RNA expression levels in NERD patients with or without subtle mucosal changes...
  39. doi request reprint Synergic effect of photodynamic therapy using talaporfin sodium with conventional anticancer chemotherapy for the treatment of bile duct carcinoma
    Yoshikazu Nonaka
    Division of Surgical Oncology, Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Surg Res 181:234-41. 2013
    ..The study objective was to evaluate the synergic effect of PDT using a new photosensitizer, talaporfin sodium (Laserphyrin), in combination with conventional anticancer drug treatments...
  40. doi request reprint Evaluation of surgical resection for gallbladder carcinoma at a Japanese cancer institute
    Atsushi Nanashima
    Division of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Hepatogastroenterology 59:1717-21. 2012
    ..An assessment of the surgical results and chemotherapy options may elucidate effective treatments...
  41. doi request reprint Enhanced expression of CXCL13 in human Helicobacter pylori-associated gastritis
    Yujiro Nakashima
    Second Department of Internal Medicine, Nagasaki University Hospital, Sakamoto 1 7 1, Nagasaki, 852 8102, Japan
    Dig Dis Sci 56:2887-94. 2011
    ..In this study, we sought to examine CXCL13 expression in the H. pylori-infected and -uninfected gastric mucosa and to elucidate the implication in the pathogenesis of HAG in humans...
  42. ncbi request reprint Low plasma ghrelin levels in patients with Helicobacter pylori-associated gastritis
    Hajime Isomoto
    Second Department of Internal Medicine, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Japan
    Am J Med 117:429-32. 2004
  43. doi request reprint Endoscopic submucosal dissection for colorectal epithelial neoplasms
    Hitoshi Nishiyama
    Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Sakamoto, Nagasaki, Japan
    Dis Colon Rectum 53:161-8. 2010
    ..Endoscopic submucosal dissection permits removal of colorectal epithelial neoplasms en bloc, but long-term clinical outcomes remain unknown...
  44. ncbi request reprint Enhanced expression of interleukin-8 and activation of nuclear factor kappa-B in endoscopy-negative gastroesophageal reflux disease
    Hajime Isomoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Shunkaikai Inoue Hospital, Nagasaki, Japan
    Am J Gastroenterol 99:589-97. 2004
    ..The purpose of this study was to determine IL-8 messenger ribonucleic acid (mRNA) expression levels in endoscopy-negative GERD, along with assessment of nuclear factor kappaB (NF-kappaB) activation, which upregulates IL-8 expression...
  45. ncbi request reprint Enhanced production of leptin in gastric fundic mucosa with Helicobacter pylori infection
    Yoshito Nishi
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    World J Gastroenterol 11:695-9. 2005
    ..To determine the concentrations of leptin in plasma and gastric fundic mucosa in humans, with reference to Helicobacter pylori (H pylori) infection, and their association with gastric mucosal levels of interleukin (IL)-1beta, IL-6 and IL-8...
  46. ncbi request reprint Relation among plasma ghrelin level, gastric emptying, and psychologic condition in patients with functional dyspepsia
    Ken Ichi Takamori
    Second Department of Internal Medicine, Nagasaki University School of Medicine, National Nagasaki Medical Center, Nagasaki, Japan
    J Clin Gastroenterol 41:477-83. 2007
    ..The present study was designed to investigate plasma ghrelin levels and their relation with gastric emptying and psychologic status in FD...
  47. doi request reprint Factors related to the curability of early gastric cancer with endoscopic submucosal dissection
    Ken Ohnita
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Surg Endosc 23:2713-9. 2009
    ..It is suggested that larger, ulcerative, or upper EGCs may prevent successful ESD. A detailed analysis of factors associated with the curability of ESD was performed...
  48. pmc MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells
    Kayoko Matsushima
    Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Sakamoto, Nagasaki, Japan
    J Transl Med 9:30. 2011
    ..Accumulating evidence indicates that deregulation of miR is associated with human malignancies including ESCC. The aim of this study was to identify miR that could be specifically expressed and exert distinct biological actions in ESCC...
  49. ncbi request reprint Predictive value of the fibrosis scores in patients with chronic hepatitis C associated with liver fibrosis and metabolic syndrome
    Hisamitsu Miyaaki
    Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Japan
    Intern Med 50:1137-41. 2011
    ..We evaluated patients with chronic hepatitis C (CHC) and compared the clinical and pathological features of steatosis and metabolic syndrome to identify the risk factors for CHC with severe fibrosis...
  50. ncbi request reprint High plasma osteopontin levels in patients with inflammatory bowel disease
    Ryosuke Mishima
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Sakamoto, Nagasaki, Japan
    J Clin Gastroenterol 41:167-72. 2007
    ..Osteopontin (OPN) plays a key role in the progression of T(H)1-immune-mediated disease in models of multiple sclerosis and rheumatoid arthritis...
  51. doi request reprint Endoscopic submucosal dissection for rectal carcinoid tumors
    Naoyuki Yamaguchi
    Department of Endoscopy, Nagasaki University Hospital, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Surg Endosc 24:504-8. 2010
    ..The ESD procedure is the treatment of choice for rectal carcinoids that have classic histologic architecture with minimal cellular pleomorphism and sparse mitoses, but it has not been applied for such tumors...
  52. pmc Improvement of endocytoscopic findings after per oral endoscopic myotomy (POEM) in esophageal achalasia; does POEM reduce the risk of developing esophageal carcinoma? Per oral endoscopic myotomy, endocytoscopy and carcinogenesis
    Hitomi Minami
    Department of Gastroenterology and Hepatology, Nagasaki University Hospital, 1 7 1, Sakamoto, Nagasaki 852 8501, Japan
    BMC Gastroenterol 13:22. 2013
    ..Per oral endoscopic myotomy (POEM) has been reported to be a new therapeutic option for esophageal achalasia. The possibility that POEM could reduce the risk of developing esophageal squamous cell carcinoma was evaluated...
  53. doi request reprint Comparison of postoperative morbidity in elderly patients who underwent pancreatic resection
    Atsushi Nanashima
    Department of Surgery, Nagasaki University Hospital, Nagasaki, Japan
    Hepatogastroenterology 59:1141-6. 2012
    ..Operative indications for pancreatectomy in elderly patients with pancreatic disease remain controversial. We examined clinicopathological characteristics and early outcomes in each generation of 147 patients who underwent pancreatectomy...
  54. pmc Enhanced expression of CCL20 in human Helicobacter pylori-associated gastritis
    Akira Yoshida
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Sakamoto, Nagasaki 852 8501, Japan
    Clin Immunol 130:290-7. 2009
    ..The CCL20/CCR6 interaction may be involved in the development of H. pylori-associated gastritis...
  55. ncbi request reprint Elevated concentrations of alpha-defensins in gastric juice of patients with Helicobacter pylori infection
    Hajime Isomoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Am J Gastroenterol 99:1916-23. 2004
    ..Defensins (alpha- and beta-defensins) are endogenous antimicrobial peptides. Little is known about alpha-defensins during Helicobacter pylori infection...
  56. ncbi request reprint A case of Cronkhite-Canada syndrome: remission after treatment with anti-Helicobacter pylori regimen
    Kenta Okamoto
    Department of Internal Medicine, Nagasaki National Medical Center, Omura, Japan
    Digestion 78:82-7. 2008
    ..At the follow-up magnifying endoscopic examination 8 months later, small round or round-oval pits were densely and regularly distributed...
  57. doi request reprint Endoscopic submucosal dissection for laterally spreading tumours of the colorectum in 200 consecutive cases
    Hitoshi Nishiyama
    Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Surg Endosc 24:2881-7. 2010
    ..We assessed the clinicopathological factors associated with clinical outcomes of endoscopic submucosal dissection (ESD) for colorectal LSTs, and conducted follow-up after ESD...
  58. ncbi request reprint Expression of mucosal addressin cell adhesion molecule 1 on vascular endothelium of gastric mucosa in patients with nodular gastritis
    Hiroshi Ohara
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki, Japan
    World J Gastroenterol 9:2701-5. 2003
    ..The purpose of this study was to address the implication of the MAdCAM-1/integrin beta7 pathway in NG...
  59. pmc Strong evidence of a combination polymorphism of the tyrosine kinase 2 gene and the signal transducer and activator of transcription 3 gene as a DNA-based biomarker for susceptibility to Crohn's disease in the Japanese population
    Kayoko Sato
    Department of Pharmacotherapeutics, Nagasaki University Graduate School of Biomedical Sciences, Bunkyo Machi, Nagasaki, Japan
    J Clin Immunol 29:815-25. 2009
    ....
  60. ncbi request reprint Clinical outcomes of endoscopic submucosal dissection for early gastric cancer by indication criteria
    Naoyuki Yamaguchi
    Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Second Department of Internal Medicine, Nagasaki, Japan
    Digestion 80:173-81. 2009
    ..Endoscopic submucosal dissection (ESD) can remove early gastric cancer (EGC) en bloc. We sought to assess the feasibility and efficacy of ESD and the clinical outcomes based on the indication criteria...
  61. ncbi request reprint Impact of Helicobacter pylori infection on gastric and plasma ghrelin dynamics in humans
    Hajime Isomoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Sakamoto, Nagasaki, Japan
    Am J Gastroenterol 100:1711-20. 2005
    ..There are contradictory reports on the relationship between Helicobacter pylori and circulating ghrelin. We sought to clarify the influence of H. pylori infection on gastric and plasma ghrelin dynamics in humans...
  62. ncbi request reprint Expression of heat shock protein (Hsp) 70 and Hsp 40 in gastric cancer
    Hajime Isomoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Cancer Lett 198:219-28. 2003
    ..Overexpression of Hsp 70 and Hsp 40 was also confirmed by immunoblotting. Among various clinicopathological parameters, low histopathological differentiation was associated with reduced expression of both proteins...
  63. doi request reprint Effect of oral prednisolone on esophageal stricture after complete circular endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma: a case report
    Naoyuki Yamaguchi
    Department of Endoscopy, Nagasaki University Hospital, Nagasaki, Japan
    Digestion 83:291-5. 2011
    ..Oral prednisolone administration may offer an effective therapeutic strategy to prevent the post-ESD esophageal stricture after complete circular ESD...
  64. doi request reprint MicroRNA signatures in Helicobacter pylori-infected gastric mucosa
    Kayoko Matsushima
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University School of Medicine, Nagasaki, Japan
    Int J Cancer 128:361-70. 2011
    ..These results provide insights into miRNA involvement in the pathogenesis of H. pylori-associated gastritis. cagA may be involved in cellular regulation of certain miRNAs in the gastric epithelium...
  65. doi request reprint Geranylgeranylacetone has anti-hepatitis C virus activity via activation of mTOR in human hepatoma cells
    Shigeyuki Takeshita
    Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Gastroenterol 47:195-202. 2012
    ..This study verified the anti-HCV activity of GGA in a replicon system. In addition, mechanisms of anti-HCV activity were examined in the replicon cells...
  66. ncbi request reprint Adult T-cell leukemia with colorectal involvement
    Yuki Asada
    Department of Internal Medicine, National Nagasaki Medical Center, Omura, Japan
    Gastrointest Endosc 60:983-4. 2004
  67. doi request reprint Helicobacter pylori VacA reduces the cellular expression of STAT3 and pro-survival Bcl-2 family proteins, Bcl-2 and Bcl-XL, leading to apoptosis in gastric epithelial cells
    Ayako Matsumoto
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, and Department of Gastroenterology and Hepatology, Nagasaki University Hospital, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Dig Dis Sci 56:999-1006. 2011
    ..Signal transduction and activator of transcription 3 (STAT3) is a pivotal transcription factor that upregulates Bcl-2 and Bcl-XL...
  68. doi request reprint Magnifying chromoendoscopic findings of early gastric cancer and gastric adenoma
    Ken Ohnita
    Department of Gastroenterology and Hepatology, Nagasaki University Hospital, 1 7 1 Sakamoto, Nagasaki 852 8102, Japan
    Dig Dis Sci 56:2715-22. 2011
    ..However, there was limited information on magnified endoscopic findings with CV staining for gastric neoplasms in terms of their pit patterns...
  69. ncbi request reprint Crohn's disease in Japanese is associated with a SNP-haplotype of N-acetyltransferase 2 gene
    Haruhisa Machida
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    World J Gastroenterol 11:4833-7. 2005
    ..To investigate the frequency and distribution of N-acetyltransferase 2 (NAT2) and uridine 5'-diphosphate (UDP)-glucuronosyltransferase 1A7 (UGT1A7) genes in patients with ulcerative colitis (UC) and Crohn's disease (CD)...
  70. ncbi request reprint Haplotypes of PADI4 susceptible to rheumatoid arthritis are also associated with ulcerative colitis in the Japanese population
    Chun Chuan Chen
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Clin Immunol 126:165-71. 2008
    ..215). Our results indicate that haplotype 1 of PADI4 is associated with non-susceptibility to UC, whereas haplotype 2 is susceptible to UC. Thus, it is likely that PADI4 is one of genetic determinants of UC in the Japanese population...
  71. ncbi request reprint Helicobacter pylori strain-specific modulation of gastric inflammation in Mongolian gerbils
    Ken Ohnita
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki, Japan
    World J Gastroenterol 11:1549-53. 2005
    ..The cag pathogenicity island (PAI) is one of potential virulence determinants of Helicobacter pylori. The Mongolian gerbil is a suitable experimental animal for the screening of virulence factors of H pylori...
  72. doi request reprint Insulin-induced mTOR activity exhibits anti-hepatitis C virus activity
    Toru Muraoka
    Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    Mol Med Rep 5:331-5. 2012
    ..mTOR activity may be associated with the HCV life cycle. Future studies should, therefore, attempt to identify new agents that activate mTOR to promote anti-HCV activity...
  73. ncbi request reprint Development of ulcerative colitis during the course of rheumatoid arthritis: Association with selective IgA deficiency
    Yuki Asada
    Department of Internal Medicine, National Nagasaki Medical Center, 1001 1 Kubara, Omura, Japan
    World J Gastroenterol 12:5240-3. 2006
    ..Laboratory tests revealed low serum and saliva IgA levels, which might play a role in the development of UC. To our knowledge, this is the first case of UC occurring during the course of RA, accompanied by selective IgA deficiency...
  74. ncbi request reprint Flow cytometric analysis of expression of transforming growth factor-beta and glucocorticoid-induced tumor necrosis factor receptor on CD4(+) CD25(+) T cells of patients with inflammatory bowel disease
    Maho Ikeda
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Dig Dis Sci 51:178-84. 2006
    ..7 +/- 2.6 and 7.2 +/- 3.9%, respectively). The results suggest that TGF-beta is involved in the induction or sustained remission of UC...
  75. ncbi request reprint Pneumatosis intestinalis in ulcerative colitis
    Ayako Matsumoto
    Department of Internal Medicine, National Nagasaki Medical Center, Omura, Japan
    Med Sci Monit 15:CS139-42. 2009
    ..UC patients are considered to be at risk for pneumatosis intestinalis (PI)...
  76. ncbi request reprint A possible mouse model for spontaneous cholangitis: serological and histological characteristics of MRL/lpr mice
    Kazuo Ohba
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan
    Pathology 34:250-6. 2002
    ..The aim of this study was to determine the suitability of MRL/Mp-lpr/lpr (MRL/lpr) mice as an experimental auto-immune-mediated cholangitis model for PBC...
  77. ncbi request reprint Five minute endoscopic urea breath test with 25 mg of (13)C-urea in the management of Helicobacter pylori infection
    Hajime Isomoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Eur J Gastroenterol Hepatol 14:1093-100. 2002
    ..This study was conducted to determine whether the (13)C-EUBT using low doses of urea and short sampling times could preserve accuracy in the management of H. pylori infection...
  78. ncbi request reprint Preliminary analysis of a newly proposed prognostic scoring system (SLiDe score) for hepatocellular carcinoma
    Katsuhisa Omagari
    Second Department of Internal Medicine, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan
    J Gastroenterol Hepatol 19:805-11. 2004
    ..Therefore, a prognostic classification of HCC should account for both tumor-related variables and liver function...
  79. doi request reprint A new thin endoscopic method of transanal drainage tube insertion for acute colonic obstruction due to colorectal cancer
    Ken Ohnita
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Dig Endosc 21:252-4. 2009
    ..Insertion of a transanal drainage tube is effective in the management of obstructing colorectal cancer. We devised a new method of inserting the transanal drainage tube safely and quickly using a thin endoscope...
  80. ncbi request reprint Proximal extension of backwash ileitis in ulcerative-colitis - associated colon cancer
    Naoyuki Yamaguchi
    2nd Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Med Sci Monit 16:CS87-91. 2010
    ..Ulcerative colitis patients with pancolitis and backwash ileitis may be at increased risk of colorectal carcinoma. A case of ulcerative colitis-associated cancer with backwash ileitis, which extended proximally over time, is described...
  81. ncbi request reprint Influence of Helicobacter pylori infection on in vitro responsiveness of gastric fundus to agonists and to stimulation of enteric nerves in Mongolian gerbils
    Yusuke Takehara
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Gastroenterol 37:589-95. 2002
    ..pylori infection on the responsiveness of smooth muscles of the gastric fundus to agonists or to stimulation of enteric nerves, with particular emphasis on nonadrenergic noncholinergic (NANC) relaxation...
  82. ncbi request reprint Validation of endoscopic 13C-urea breath test with nondispersive infrared spectrometric analysis in the management of Helicobacter pylori infection
    Hajime Isomoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Hepatogastroenterology 50:422-5. 2003
    ..We validated the diagnostic performance of 13C-EUBT using nondispersive infrared spectrometer in the management of H. pylori infection...
  83. ncbi request reprint Clinical significance of positive immunoblotting but negative immunofluorescence for antimitochondrial antibodies in patients with liver diseases other than primary biliary cirrhosis
    Jun Ichi Masuda
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Sakamoto, Japan
    Autoimmunity 35:135-41. 2002
    ..Further prospective studies of larger population should clarify whether anti-2-OADC reaction can precede the clinical development of PBC...
  84. ncbi request reprint Ulcerative colitis complicating pseudomembranous colitis of the right colon
    Aiping Wang
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan
    J Gastroenterol 37:309-12. 2002
    ..Total colonoscopy is recommended for precise diagnosis when patients with ulcerative colitis develop intractable diarrhea during or after antibiotic therapy...
  85. ncbi request reprint A case of acute gastric mucosal lesions associated with Helicobacter heilmannii infection
    Masaya Yoshimura
    Internal Medicine, Omura Municipal Hospital, 132 1 Kogashima, Omura, Japan
    Helicobacter 7:322-6. 2002
    ..heilmannii-associated acute gastric mucosal lesions, diagnosed by morphology using touch cytology and histology. The patient might benefit from antimicrobial treatment employing the regimen effective for H. pylori...
  86. ncbi request reprint Recent insights into digestive motility in functional dyspepsia
    Yohei Mizuta
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Gastroenterol 41:1025-40. 2006
    ..This review discusses recent research on the pathophysiology of and treatment options for FD, with special attention given to digestive dysmotility...
  87. ncbi request reprint Epigenetic alterations associated with cholangiocarcinoma (review)
    Hajime Isomoto
    Department of Endoscopy, Nagasaki University Hospital of Medicine and Dentistry, Nagasaki 852 8501, Japan
    Oncol Rep 22:227-32. 2009
    ..This review provides a comprehensive overview of the genes currently known to be hypermethylated in CCA and their putative roles in cholangiocarcinogenesis. The epigenetic role of mir in the pathogenesis of CCA is also discussed...
  88. ncbi request reprint [A case of sacroiliitis complicated with ulcerative colitis which was treated with leukocytapheresis]
    Daisuke Norimura
    Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Japan
    Nihon Shokakibyo Gakkai Zasshi 107:605-11. 2010
    ..Sacroiliitis complicated with ulcerative colitis is rare in Japan, and its treatment and pathogenesis remain unclear. We report an unusual case of sacroiliitis complicated with ulcerative colitis, which was successfully treated by LCAP...
  89. ncbi request reprint [Helicobacter heilmannii-associated gastritis]
    Hajime Isomoto
    Department of Endoscopy, Nagasaki University School of Medicine
    Nihon Rinsho 60:791-5. 2002
  90. ncbi request reprint Differences in prognostic factors according to viral status in patients with hepatocellular carcinoma
    Hiroshi Akahoshi
    Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852 8501, Japan
    Oncol Rep 23:1317-23. 2010
    ..However, in early-stage patients, patients with HCC-nonBC showed significantly better prognosis than those in the HCC-virus group...
  91. ncbi request reprint Different distribution of mast cells and macrophages in colonic mucosa of patients with collagenous colitis and inflammatory bowel disease
    Yoshiyuki Nishida
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Hepatogastroenterology 49:678-82. 2002
    ..The aim of this study was to compare the distribution of mast cells and macrophages in the colonic mucosa of patients with collagenous colitis, Crohn's disease, and ulcerative colitis...
  92. ncbi request reprint Two cases of adult T-cell leukaemia/lymphoma with oesophageal involvement
    Hajime Isomoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Eur J Gastroenterol Hepatol 14:449-52. 2002
    ..Combination chemotherapy was ineffective in both cases. Prospective and careful examination of additional cases may eventually provide specific advice for treatment of this unusual condition...
  93. ncbi request reprint Enhanced expression of transcription factor E2F in Helicobacter pylori-infected gastric mucosa
    Hajime Isomoto
    The Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan
    Helicobacter 7:152-62. 2002
    ..The aim of this study was to investigate the expression of E2F in H. pylori-infected gastric mucosa and examine the correlation between such expression and gastric epithelial cell proliferation and apoptosis...
  94. ncbi request reprint Analysis of apoptotic effects induced by photodynamic therapy in a human biliary cancer cell line
    Takashi Nonaka
    Department of Regenerative Oral Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
    Anticancer Res 30:2113-8. 2010
    ..This study investigated the mechanisms of human biliary cancer cell death by PDT by focusing on apoptosis induction in vitro and in vivo...
  95. ncbi request reprint Enlarged accessory spleen presenting stomach submucosal tumor
    Shunzen Chin
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    World J Gastroenterol 13:1752-4. 2007
    ..99m)Technetium sulfur colloid scintigraphy revealed the splenic nature of the mass. A diagnosis of accessory spleen mimicking gastric SMT was made. Subsequent follow-up was uneventful without performing splenectomy...
  96. ncbi request reprint Helicobacter pylori infection in patients with gastric involvement by adult T-cell leukemia/lymphoma
    Ken Ohnita
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Cancer 94:1507-16. 2002
    ..pylori infection and ATLL gastric involvement has not been investigated...
  97. ncbi request reprint A case of double pylorus caused by recurrent gastric ulcers: a long-term endoscopic observation
    Yuko Akazawa
    Department of Internal Medicine, Omura Municipal Hospital, Nagasaki, Japan
    Dig Dis Sci 50:2125-8. 2005
  98. pmc Molecular characterization of Helicobacter pylori VacA induction of IL-8 in U937 cells reveals a prominent role for p38MAPK in activating transcription factor-2, cAMP response element binding protein, and NF-kappaB activation
    Junzo Hisatsune
    Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
    J Immunol 180:5017-27. 2008
    ..Thus, in U937 cells, VacA directly increases IL-8 production by activation of the p38 MAPK via intracellular Ca(2+) release, leading to activation of the transcription factors, ATF-2, CREB, and NF-kappaB...
  99. ncbi request reprint Association of polymorphic alleles of CTLA4 with inflammatory bowel disease in the Japanese
    Haruhisa Machida
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852 8501, Japan
    World J Gastroenterol 11:4188-93. 2005
    ....