T Yanai

Summary

Affiliation: Gifu University
Country: Japan

Publications

  1. pmc Proliferative potential of a spinal nephroblastoma in a young dog
    George Ohta
    Department of Veterinary Pathology, Faculty of Applied Biological Science, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    J Toxicol Pathol 22:79-82. 2009
  2. ncbi request reprint Susceptibility of BALB/c-nu/nu mice and BALB/c mice to equine herpesvirus 9 infection
    E El-Nahass
    Department of Veterinary Pathology and Microbiology, Faculty of Applied Biological Science, Gifu University, 1 1 Yanagido, Gifu 501 1193 Japan Email
    Vet Pathol 51:581-90. 2014
  3. pmc Constitutive phosphorylation of the mTORC2/Akt/4E-BP1 pathway in newly derived canine hemangiosarcoma cell lines
    Atsuko Murai
    Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1 1 Yanagido, Gifu, 501 1193, Japan
    BMC Vet Res 8:128. 2012
  4. doi request reprint Spontaneous T/NK-cell lymphoma associated with simian lymphocryptovirus in a Japanese macaque (Macaca fuscata)
    A Hirata
    Division of Animal Experiment, Life Science Research Center, Japan
    J Comp Pathol 148:43-6. 2013
  5. doi request reprint Disseminated mycosis in a killer whale (Orcinus orca)
    Walied Abdo
    Laboratory of Veterinary Pathology, Gifu University, Gifu, Japan
    J Vet Diagn Invest 24:211-8. 2012
  6. pmc Establishment of canine hemangiosarcoma xenograft models expressing endothelial growth factors, their receptors, and angiogenesis-associated homeobox genes
    Atsushi Kodama
    Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Gifu University, Gifu, Japan
    BMC Cancer 9:363. 2009
  7. doi request reprint Immunohistochemical demonstration of angiogenesis-associated homeobox proteins in canine vascular tumours
    A Kodama
    Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    J Comp Pathol 141:199-203. 2009
  8. doi request reprint Kinetics and pathogenicity of oral infection by equine herpesvirus-9 in mice and suckling hamsters
    E El-Nahass
    Department of Veterinary Pathology, Faculty of Applied Biological Science, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    J Comp Pathol 146:211-22. 2012
  9. doi request reprint Study on the infectivity of equine herpesvirus 9 (EHV-9) by different routes of inoculation in hamsters
    N El-Habashi
    Department of Veterinary Pathology and Microbiology, Gifu University, Gifu 501 1193 Japan
    Vet Pathol 48:558-64. 2011
  10. ncbi request reprint Activation of matrix metalloproteinase (MMP)-2 by membrane type 1-MMP and abnormal immunolocalization of the basement membrane components laminin and type IV collagen in canine spontaneous hemangiosarcomas
    M Murakami
    Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Yanagido, Gifu, Japan
    Histol Histopathol 24:437-46. 2009

Collaborators

Detail Information

Publications42

  1. pmc Proliferative potential of a spinal nephroblastoma in a young dog
    George Ohta
    Department of Veterinary Pathology, Faculty of Applied Biological Science, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    J Toxicol Pathol 22:79-82. 2009
    ..The present tumor showed a high potential for growth and invasion, which suggests that it the potential to expand into the adjacent spinal cord...
  2. ncbi request reprint Susceptibility of BALB/c-nu/nu mice and BALB/c mice to equine herpesvirus 9 infection
    E El-Nahass
    Department of Veterinary Pathology and Microbiology, Faculty of Applied Biological Science, Gifu University, 1 1 Yanagido, Gifu 501 1193 Japan Email
    Vet Pathol 51:581-90. 2014
    ....
  3. pmc Constitutive phosphorylation of the mTORC2/Akt/4E-BP1 pathway in newly derived canine hemangiosarcoma cell lines
    Atsuko Murai
    Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1 1 Yanagido, Gifu, 501 1193, Japan
    BMC Vet Res 8:128. 2012
    ..Here, we characterized new canine HSA cell lines derived from nude mice-xenografted canine HSAs and investigated the deregulation of the signaling pathways in these cell lines...
  4. doi request reprint Spontaneous T/NK-cell lymphoma associated with simian lymphocryptovirus in a Japanese macaque (Macaca fuscata)
    A Hirata
    Division of Animal Experiment, Life Science Research Center, Japan
    J Comp Pathol 148:43-6. 2013
    ..This is the first report of simian LCV-associated T/NK-cell lymphoma with the predominant expression of T-cell antigens in non-human primates...
  5. doi request reprint Disseminated mycosis in a killer whale (Orcinus orca)
    Walied Abdo
    Laboratory of Veterinary Pathology, Gifu University, Gifu, Japan
    J Vet Diagn Invest 24:211-8. 2012
    ..The present case involves dual infection with Mucor and Aspergillus species in a killer whale with concurrent herpesvirus...
  6. pmc Establishment of canine hemangiosarcoma xenograft models expressing endothelial growth factors, their receptors, and angiogenesis-associated homeobox genes
    Atsushi Kodama
    Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Gifu University, Gifu, Japan
    BMC Cancer 9:363. 2009
    ..In the present study, we established 6 xenograft canine HSA tumors and detected the expression of growth factors, their receptors, and angiogenic homeobox genes...
  7. doi request reprint Immunohistochemical demonstration of angiogenesis-associated homeobox proteins in canine vascular tumours
    A Kodama
    Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    J Comp Pathol 141:199-203. 2009
    ..Overall, homeobox protein expression in HSA appears to have a phenotype similar to that of active ECs in angiogenesis. The expression of homeobox genes associated with angiogenesis might be associated with the malignant growth of HSA...
  8. doi request reprint Kinetics and pathogenicity of oral infection by equine herpesvirus-9 in mice and suckling hamsters
    E El-Nahass
    Department of Veterinary Pathology, Faculty of Applied Biological Science, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    J Comp Pathol 146:211-22. 2012
    ..These findings show that EHV-9 may spread via the trigeminal nerve when mice and hamsters are inoculated orally with virus...
  9. doi request reprint Study on the infectivity of equine herpesvirus 9 (EHV-9) by different routes of inoculation in hamsters
    N El-Habashi
    Department of Veterinary Pathology and Microbiology, Gifu University, Gifu 501 1193 Japan
    Vet Pathol 48:558-64. 2011
    ..These results suggest that in the animals infected by the oral, ocular, and peritoneal routes, EHV-9 might travel to the brain through nerves, other than by the olfactory route, after initial propagation at the site of viral entry...
  10. ncbi request reprint Activation of matrix metalloproteinase (MMP)-2 by membrane type 1-MMP and abnormal immunolocalization of the basement membrane components laminin and type IV collagen in canine spontaneous hemangiosarcomas
    M Murakami
    Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Yanagido, Gifu, Japan
    Histol Histopathol 24:437-46. 2009
    ..In canine HSA, neoplastic cells had active MMP-2, possibly activated by MT1-MMP, and discontinuous status of BM might be associated with activity of active MMP-2...
  11. ncbi request reprint Expression of platelet-derived growth factor and its receptors in spontaneous canine hemangiosarcoma and cutaneous hemangioma
    S Abou Asa
    Laboratory of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan
    Histol Histopathol 27:601-7. 2012
    ..01), while PDGFR-α was highly expressed in cutaneous HA and may be related to pathogenesis of cutaneous HA. Therefore, PDGFR-β may be associated with the malignant nature of canine HSA...
  12. doi request reprint The class A macrophage scavenger receptor CD204 is a useful immunohistochemical marker of canine histiocytic sarcoma
    Y Kato
    Laboratory of Veterinary Pathology, Life Science Research Centre, Gifu University, 1 1 Yanagido, Gifu, Japan
    J Comp Pathol 148:188-96. 2013
    ..None of the pleomorphic sarcomas were immunoreactive for CD204. CD204 would appear to be a useful marker for canine HS...
  13. doi request reprint Immunohistochemical analysis of the Akt/mTOR/4E-BP1 signalling pathway in canine haemangiomas and haemangiosarcomas
    A Murai
    Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan
    J Comp Pathol 147:430-40. 2012
    ..Because mTORC2 and phosphorylates Akt Ser473 was activated in HSA samples, the present findings suggest that the mTORC2/Akt/4E-BP1 pathway, regulated independently of mTORC1, may be important for targeting therapy in canine HSAs...
  14. doi request reprint Kinetics and pathogenicity of equine herpesvirus-9 infection following intraperitoneal inoculation in hamsters
    E El-Nahass
    Department of Veterinary Pathology, Faculty of Applied Biological Science, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    J Comp Pathol 145:271-81. 2011
    ..Examination of other organs also revealed the presence of EHV-9, suggesting that the virus might infect tissues other than those of the nervous system...
  15. doi request reprint Pathological features of Mycobacterium kansasii infection in black bearded sakis (Chiropotes satanas)
    A Murai
    Laboratory of Veterinary Pathology, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    J Comp Pathol 147:566-9. 2012
    ..Mycobacterium kansasii was identified by PCR in the lymph nodes of the animal with disseminated disease. Mycobacterial speciation was not as readily achieved in the animal with cutaneous nodules only...
  16. doi request reprint Expression of the anti-apoptotic factors Bcl-2 and survivin in canine vascular tumours
    M Murakami
    Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    J Comp Pathol 139:1-7. 2008
    ..The discrepancy between bcl-2 mRNA and bcl-2 protein expression requires further investigation, but the results suggest that malignant proliferation in canine HSAs is associated with bcl-2 and survivin expression...
  17. ncbi request reprint Acute neuropathogenicity with experimental infection of equine herpesvirus 9 in common marmosets (Callithrix jacchus)
    A Kodama
    Department of Veterinary Pathology, Gifu University, Gifu, Japan
    J Med Primatol 36:335-42. 2007
    ..Equine herpesvirus 9 (EHV-9) is a new neurotropic equine herpesvirus which induced encephalitis in a variety of animals. However, there was no information on the susceptibility of EHV-9 in primates...
  18. doi request reprint Analysis of KIT expression and KIT exon 11 mutations in canine oral malignant melanomas
    A Murakami
    Laboratory of Veterinary Clinical Oncology, Department of Veterinary Medicine, Gifu University, Gifu, Japan
    Vet Comp Oncol 9:219-24. 2011
    ..For several reasons, however, KIT expression and mutations of various exons including exon 11 should be investigated in more cases...
  19. ncbi request reprint Expression of cyclin kinase inhibitor p27(Kip1) in skin tumours of dogs
    H Sakai
    Department of Veterinary Pathology, Faculty of Agriculture, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
    J Comp Pathol 125:153-8. 2001
    ..In spite of being a benign neoplasm, pilomatrixomas had a low p27 expression; this may be a reflection of the proliferative potential of the hair matrix. The expression of p27 may be a useful marker for the analysis of cell kinetics...
  20. doi request reprint Orbital embryonal rhabdomyosarcoma with metastasis in a young dog
    Y Kato
    Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    J Comp Pathol 147:191-4. 2012
    ..One month later, multiple masses throughout the body were identified, in particular around the cervical region. One of these lesions was sampled and diagnosed as metastatic ERS. The dog died 84 days after the time of first admission...
  21. doi request reprint An ocular infection model using suckling hamsters inoculated with equine herpesvirus 9 (EHV-9): kinetics of the virus and time-course pathogenesis of EHV-9-induced encephalitis via the eyes
    N El-Habashi
    Department of Veterinary Pathology and Microbiology, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    Vet Pathol 50:56-64. 2013
    ..This conjunctival EHV-9 suckling hamster model may be useful in assessing the neuronal spread of neuropathogenic viruses via the eyes to the brain...
  22. ncbi request reprint Experimental infection of equine herpesvirus 9 in dogs
    T Yanai
    Department of Veterinary Pathology and Microbiology, Faculty of Agriculture, Gifu University, Japan
    Vet Pathol 40:263-7. 2003
    ..These findings indicate that dogs are fully susceptible to EHV-9 and that EHV-9 can cause fulminant encephalitis with high mortality in dogs, as in gazelles and goats...
  23. ncbi request reprint Assessment of proliferative potentials of canine osteosarcomas and chondrosarcomas by MIB-1 immunohistochemistry and bromodeoxyuridine incorporation
    G Ohta
    Department of Veterinary Pathology, Faculty of Agriculture, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    J Comp Pathol 131:18-27. 2004
    ..The MIB-1 PI was 21.3% +/- 3.0 S.E.M. P < 0.001 in transitional areas. Proliferative markers may be useful in diagnosis and prognosis...
  24. ncbi request reprint Gazelle herpesvirus 1: a new neurotropic herpesvirus immunologically related to equine herpesvirus 1
    H Fukushi
    Faculty of Agriculture, Gifu University, Gifu, 501 11, Japan
    Virology 227:34-44. 1997
    ..We conclude that GHV-1 is a new type of equine herpesvirus with strong neurotropism...
  25. ncbi request reprint Expression of vascular endothelial growth factor, basic fibroblast growth factor, and their receptors (flt-1, flk-1, and flg-1) in canine vascular tumors
    K Yonemaru
    Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    Vet Pathol 43:971-80. 2006
    ..These results suggest that the expression of the growth factors and their receptors, especially flk-1, might be associated with the malignant proliferation of HSAs...
  26. doi request reprint Effects of equine herpesvirus-9 infection in pregnant mice and hamsters
    N El-Habashi
    Department of Veterinary Pathology, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    J Comp Pathol 144:103-12. 2011
    ..These results suggest that EHV-9 can cause the death of the fetus or abortion and that these events may be secondary to placental vascular compromise...
  27. doi request reprint A pathological study of sepsis associated with sarcoptic mange in raccoon dogs (Nyctereutes procyonoides) in Japan
    T L D R Nakagawa
    Division of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    J Comp Pathol 141:177-81. 2009
    ..This infection was therefore very similar to "crusted scabies" or "Norwegian scabies" in man and was characterized by severe pathology and high mortality, with deaths frequently occurring due to sepsis...
  28. doi request reprint AA amyloidosis in vaccinated growing chickens
    T Murakami
    Laboratory of Food and Environmental Hygiene, Department of Veterinary Medicine, Gifu University, Gifu, Japan
    J Comp Pathol 149:291-7. 2013
    ..Amyloid deposits were also observed at a high rate in the tissues of apparently healthy chickens. Vaccination should therefore be considered as a potential risk factor for the development of AA amyloidosis in poultry. ..
  29. ncbi request reprint Detection of canine pemphigus foliaceus autoantigen by immunoblotting
    T Iwasaki
    Veterinary Medical Teaching Hospital, Gifu University, Japan
    Vet Immunol Immunopathol 59:1-10. 1997
    ..These results suggested that the autoantibodies in sera from canine PF recognised the 160 kDa desmosomal proteins, which may correspond to the desmoglein 1...
  30. doi request reprint Meningoencephalitis associated with Sarcocystis spp. in a free-living Japanese raccoon dog (Nyctereutes procyonoides viverrinus)
    M Kubo
    Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan
    J Comp Pathol 143:185-9. 2010
    ..Analysis of the partial 18S rRNA gene sequence revealed that the protozoa were most closely related to an unidentified Sarcocystis species that was isolated from the white-fronted goose (Anser albifrons)...
  31. ncbi request reprint Expression of myogenic regulating factors, Myogenin and MyoD, in two canine botryoid rhabdomyosarcomas
    M Kobayashi
    Department of Veterinary Pathology and Surgery, Faculty of Agriculture, Gifu University 1 1 Yanagido, Gifu 501 1193, Japan
    Vet Pathol 41:275-7. 2004
    ..The expressions of myogenin and MyoD were closely correlated to the histologic features of myogenic neoplastic cells...
  32. doi request reprint Nasal neuroendocrine carcinoma in a free-living Japanese raccoon dog (Nyctereutes procyonoides viverrinus)
    M Kubo
    United Graduate School of Veterinary Sciences, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    J Comp Pathol 140:67-71. 2009
    ..The tumour had infiltrated the cerebrum and metastasized to the pituitary gland, mandibular and pulmonary lymph nodes, lungs, thyroid gland and adrenal glands...
  33. ncbi request reprint Morphological and immunohistochemical features of Cryptosporidium andersoni in cattle
    K Masuno
    Department of Veterinary Pathology, Faculty of Agriculture, Gifu University 1 1 Yanagido, Gifu 501 1193, Japan
    Vet Pathol 43:202-7. 2006
    ..showed positive reactions at the wall of these oocysts or parasitophorous vacuoles. This report is possibly the first to discuss the prominent hyperplasia of the abomasum mucosa, as well as morphologic features of C. andersoni in cattle...
  34. doi request reprint Genetic characterization of Protostrongylus shiozawai from Japanese serows (Capricornis crispus)
    M Murakami
    Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    J Parasitol 97:1178-80. 2011
    ..PCR using genetic markers in the ITS-2 region should provide a useful tool for expanded studies of P. shiozawai and other Protostrongylus species...
  35. ncbi request reprint Malignant melanoma of the palpebral conjunctiva in a captive fallow deer
    H Sakai
    Department of Veterinary Pathology, Faculty of Agriculture, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    J Wildl Dis 37:816-9. 2001
    ..Numerous mitotic figures and lymphatic invasions were observed. This is a very rare case of a malignant melanoma arising from the palpebral conjunctiva in a wild ruminant...
  36. ncbi request reprint Detection of antibodies against Pasteurella multocida using immunohistochemical staining in an outbreak of rabbit pasteurellosis
    H Takashima
    Department of Veterinary Pathology, Faculty of Agriculture, Gifu University, Japan
    J Vet Med Sci 63:171-4. 2001
    ..multocida were first detected 7 days after the onset of the disease. IgG antibodies began to rise on the 7th or 14th day. These results suggested that the modified immunoperoxidase assay could detect antibodies against P. multocida...
  37. ncbi request reprint Lingual calcinosis circumscripta in a captive sitatunga
    T Yanai
    Department of Veterinary Pathology, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    J Wildl Dis 37:813-5. 2001
    ..The amorphous material was positive for PAS and von Kossa's stain. Calcinosis circumscripta is rare in the Bovidae...
  38. ncbi request reprint Teratoma of the umbilical cord in a giraffe (Giraffa camelopardalis reticulata)
    A Murai
    Department of Veterinary Pathology, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    Vet Pathol 44:204-6. 2007
    ..Based on these findings, the tumor was diagnosed as a teratoma originating from the umbilical cord. This is possibly the second reported case of umbilical cord teratoma in animals...
  39. doi request reprint Levels of infection of gastric nematodes in a flock of great cormorants (Phalacrocorax carbo) from Lake Biwa, Japan
    Kh M El-Dakhly
    Department of Veterinary Pathology, Gifu University, Gifu, Japan
    J Helminthol 86:54-63. 2012
    ..Microscopically, varying degrees of granulomatous inflammatory reactions were seen, in addition to degenerated nematodes which appeared to have deeply penetrated mucosal surfaces and were surrounded by fibrous connective tissues...
  40. ncbi request reprint Lingual squamous cell carcinoma in an ocelot (Felix pardalis)
    T Yanai
    Department of Veterinary Pathology, Faculty of Agriculture, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    Vet Rec 152:656-7. 2003
  41. ncbi request reprint Experimental infection with equine herpesvirus 9 (EHV-9) in cats
    T Yanai
    Department of Veterinary Pathology and Microbiology, Faculty of Agriculture, Gifu University, 1 1 Yanagido, Gifu, 501 1193, Japan
    J Comp Pathol 128:113-8. 2003
    ..These findings indicate that the cat, like certain other species such as the goat, is susceptible to experimental infection with EHV-9, and may be at risk from natural infection...
  42. doi request reprint Pulmonary zygomycosis with Cunninghamella bertholletiae in a killer whale (Orcinus orca)
    W Abdo
    Department of Veterinary Pathology, Faculty of Applied Biological Science, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    J Comp Pathol 147:94-9. 2012
    ..Bacteriological culture revealed the presence of Proteus mirabilis, Pseudomonas aeruginosa and Pseudomonas oryzihabitans. This case represents the first documentation of zygomycosis associated with C. bertholletiae in a marine mammal...