Masashi Tanaka

Summary

Affiliation: Gifu International Institute of Biotechnology
Country: Japan

Publications

  1. ncbi Golden mean to longevity: rareness of mitochondrial cytochrome b variants in centenarians but not in patients with Parkinson's disease
    Masashi Tanaka
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Mitake, Gifu, Japan
    J Neurosci Res 70:347-55. 2002
  2. ncbi Gene therapy for mitochondrial disease by delivering restriction endonuclease SmaI into mitochondria
    Masashi Tanaka
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Mitake, Japan
    J Biomed Sci 9:534-41. 2002
  3. ncbi Mitochondrial genotypes and cytochrome b variants associated with longevity or Parkinson's disease
    Masashi Tanaka
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Yagi Memorial Park, Mitake, Gifu 505 0116, Japan
    J Neurol 249:II11-8. 2002
  4. ncbi Mitochondrial genome single nucleotide polymorphisms and their phenotypes in the Japanese
    Masashi Tanaka
    Department of Gene Therapy, Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Ann N Y Acad Sci 1011:7-20. 2004
  5. ncbi Genetic risk for coronary artery disease in individuals with or without type 2 diabetes
    Yoshiji Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Kakamigahara, Japan
    Mol Genet Metab 81:282-90. 2004
  6. pmc Mitochondrial genome variation in eastern Asia and the peopling of Japan
    Masashi Tanaka
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Kakamigahara, Gifu 504 0838, Japan
    Genome Res 14:1832-50. 2004
  7. doi Neuromelanin selectively induces apoptosis in dopaminergic SH-SY5Y cells by deglutathionylation in mitochondria: involvement of the protein and melanin component
    Makoto Naoi
    Department of Neurosciences, Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan
    J Neurochem 105:2489-500. 2008
  8. ncbi Association of a polymorphism of the transforming growth factor-beta1 gene with blood pressure in Japanese individuals
    Yoshiji Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology and Institute of Applied Biochemistry, Yagi Memorial Park, 2193 128 Mitake, Mitake cho, Kani gun, Gifu 505 0116, Japan
    J Hum Genet 47:243-8. 2002
  9. ncbi Oxidative stress in mitochondria: decision to survival and death of neurons in neurodegenerative disorders
    Makoto Naoi
    Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan
    Mol Neurobiol 31:81-93. 2005
  10. ncbi CHOP (C/EBP homologous protein) and ASNS (asparagine synthetase) induction in cybrid cells harboring MELAS and NARP mitochondrial DNA mutations
    Yasunori Fujita
    Department of Longevity and Aging Research, Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Mitochondrion 7:80-8. 2007

Detail Information

Publications61

  1. ncbi Golden mean to longevity: rareness of mitochondrial cytochrome b variants in centenarians but not in patients with Parkinson's disease
    Masashi Tanaka
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Mitake, Gifu, Japan
    J Neurosci Res 70:347-55. 2002
    ..A multiplex detection system for various deleterious variations in combination with genetic tests for longevity-associated genotypes will be necessary to predict longevity or age-related diseases...
  2. ncbi Gene therapy for mitochondrial disease by delivering restriction endonuclease SmaI into mitochondria
    Masashi Tanaka
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Mitake, Japan
    J Biomed Sci 9:534-41. 2002
    ..Delivery of restriction enzymes into mitochondria is a novel strategy for gene therapy of a special form of mitochondrial diseases...
  3. ncbi Mitochondrial genotypes and cytochrome b variants associated with longevity or Parkinson's disease
    Masashi Tanaka
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Yagi Memorial Park, Mitake, Gifu 505 0116, Japan
    J Neurol 249:II11-8. 2002
    ....
  4. ncbi Mitochondrial genome single nucleotide polymorphisms and their phenotypes in the Japanese
    Masashi Tanaka
    Department of Gene Therapy, Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Ann N Y Acad Sci 1011:7-20. 2004
    ..e., centenarians, young obese or non-obese subjects, diabetic patients with or without major vascular involvement, patients with Parkinson's disease, and those with Alzheimer's disease)...
  5. ncbi Genetic risk for coronary artery disease in individuals with or without type 2 diabetes
    Yoshiji Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Kakamigahara, Japan
    Mol Genet Metab 81:282-90. 2004
    ..Genotyping of these polymorphisms may prove informative for assessment of the genetic risk for CAD in the absence or presence of type 2 diabetes...
  6. pmc Mitochondrial genome variation in eastern Asia and the peopling of Japan
    Masashi Tanaka
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Kakamigahara, Gifu 504 0838, Japan
    Genome Res 14:1832-50. 2004
    ..All the theories that have been proposed up to now to explain the peopling of Japan seem insufficient to accommodate fully this complex picture...
  7. doi Neuromelanin selectively induces apoptosis in dopaminergic SH-SY5Y cells by deglutathionylation in mitochondria: involvement of the protein and melanin component
    Makoto Naoi
    Department of Neurosciences, Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan
    J Neurochem 105:2489-500. 2008
    ..The novel function of NM is discussed in relation to the pathogenesis of PD...
  8. ncbi Association of a polymorphism of the transforming growth factor-beta1 gene with blood pressure in Japanese individuals
    Yoshiji Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology and Institute of Applied Biochemistry, Yagi Memorial Park, 2193 128 Mitake, Mitake cho, Kani gun, Gifu 505 0116, Japan
    J Hum Genet 47:243-8. 2002
    ..These results suggest that the TGF-beta1 gene at chromosome 19q13.1 may be a candidate susceptibility locus for hypertension in Japanese women...
  9. ncbi Oxidative stress in mitochondria: decision to survival and death of neurons in neurodegenerative disorders
    Makoto Naoi
    Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan
    Mol Neurobiol 31:81-93. 2005
    ..The mechanism was proved to be the result of the modification of the 20S beta-subunit with acrolein and to the binding of other acrolein-modified proteins to the 20S beta-subunit...
  10. ncbi CHOP (C/EBP homologous protein) and ASNS (asparagine synthetase) induction in cybrid cells harboring MELAS and NARP mitochondrial DNA mutations
    Yasunori Fujita
    Department of Longevity and Aging Research, Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Mitochondrion 7:80-8. 2007
    ..These results suggest that the presence of mtDNA mutations elicits upregulation of CHOP and ASNS genes through the elevation of ATF4 expression and its binding to the AARE and NSRE-1, respectively...
  11. ncbi Association of a polymorphism of the phospholipase D2 gene with the prevalence of colorectal cancer
    Yoshiji Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology, 2193 128 Mitake, 505 0116, Gifu, Japan
    J Mol Med (Berl) 81:126-31. 2003
    ..These results suggest that the phospholipase D(2) gene is a susceptibility locus for colorectal cancer in Japanese individuals, although a functional effect of the 1814C-->T (Thr577Ile) polymorphism was not detected...
  12. ncbi Prediction of the risk of myocardial infarction from polymorphisms in candidate genes
    Yoshiji Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Mitake, Japan
    N Engl J Med 347:1916-23. 2002
    ....
  13. ncbi [Mitochondrial cardiomyopathy]
    Masashi Tanaka
    Department of Gene Therapy, Gifu International Institute of Biotechnology
    Nihon Rinsho 60:306-11. 2002
  14. ncbi Reduction in the extent of atherosclerosis in apolipoprotein E-deficient mice induced by electroporation-mediated transfer of the human plasma platelet-activating factor acetylhydrolase gene into skeletal muscle
    Makoto Hase
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Mitake, Japan
    Prostaglandins Other Lipid Mediat 70:107-18. 2002
    ..These results suggest that the electrotransfer of the plasma PAF-AH gene to skeletal muscle reduces the extent of atherosclerosis in apoE(-/-) mice...
  15. ncbi Prediction of genetic risk for dyslipidemia
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514 8507, Japan
    Genomics 90:551-8. 2007
    ....
  16. ncbi Mitochondrial DNA sequence analysis of patients with 'atypical psychosis'
    An a Kazuno
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Saitama, Japan
    Psychiatry Clin Neurosci 59:497-503. 2005
    ..However, the subhaplogroup F1b1a may be a good target for association study of 'atypical psychosis'...
  17. ncbi Mitochondrial genome polymorphisms associated with type-2 diabetes or obesity
    Li jun Guo
    Department of Sports Medicine, Graduate School of Medicine, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601, Japan
    Mitochondrion 5:15-33. 2005
    ..These results suggest that distinct mtSNPs contribute to susceptibility to type-2 diabetes or obesity, pointing out the necessity of large-scale case control studies...
  18. ncbi [Human mitochondrial genome polymorphism database (mtSNP)]
    Noriyuki Fuku
    Tanpakushitsu Kakusan Koso 50:1753-8. 2005
  19. ncbi [Mitochondrial dysfunctions and age-associated diseases]
    Yutaka Nishigaki
    Nihon Ronen Igakkai Zasshi 43:274-82. 2006
  20. pmc Identification of mitochondrial DNA polymorphisms that alter mitochondrial matrix pH and intracellular calcium dynamics
    An a Kazuno
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Saitama, Japan
    PLoS Genet 2:e128. 2006
    ..Our findings suggest that these mtDNA polymorphisms may play a role in the pathophysiology of these complex diseases by affecting mitochondrial matrix pH and intracellular calcium dynamics...
  21. ncbi Mitochondrial haplogroup N9b is protective against myocardial infarction in Japanese males
    Yutaka Nishigaki
    Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakae cho, Itabashi ku, Tokyo, Japan
    Hum Genet 120:827-36. 2007
    ..05). No significant haplogroup-related associations were detected for females. Our data suggest that haplogroup N9b confers resistance against myocardial infarction in Japanese males...
  22. pmc Mitochondrial DNA haplogroup D4a is a marker for extreme longevity in Japan
    Erhan Bilal
    BioMaPS Institute, Rutgers University, Piscataway, New Jersey, United States of America
    PLoS ONE 3:e2421. 2008
    ..The fact that the correlations are from the population structure suggests that hitch-hiking on autosomal events is a possible explanation for the observed correlations...
  23. ncbi Mitochondrial haplogroup A is a genetic risk factor for atherothrombotic cerebral infarction in Japanese females
    Yutaka Nishigaki
    Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Mitochondrion 7:72-9. 2007
    ..Our study shows that haplogroup A confers an increased risk of atherothrombotic cerebral infarction in Japanese females. Validation of our findings will require additional studies with independent subject panels...
  24. ncbi Women with mitochondrial haplogroup N9a are protected against metabolic syndrome
    Masashi Tanaka
    Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology Tokyo, 35 2 Sakae cho, Itabashi ku, Tokyo 173 0015, Japan
    Diabetes 56:518-21. 2007
    ..22 (0.06-0.68, P = 0.0129) for G1 and with an OR of 0.32 (0.10-0.96, P = 0.0469) for D5, respectively. These results indicate that mitochondrial haplogroup N9a may be a protective factor against metabolic syndrome in Japanese women...
  25. pmc Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians
    Noriyuki Fuku
    Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Am J Hum Genet 80:407-15. 2007
    ..0002) with an odds ratio of 0.55 (95% confidence interval 0.40-0.75). Even in the modern environment, which is often characterized by satiety and physical inactivity, this haplogroup might confer resistance against T2DM...
  26. ncbi Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome
    Yoshiji Yamada
    FAHA, Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Mie 514 8507, Japan
    Int J Mol Med 21:801-8. 2008
    ..Genotypes for these polymorphisms, especially for the 2445G-->A (Ala54Thr) polymorphism of FABP2, may prove informative for the prediction of genetic risk for atherothrombotic cerebral infarction among such individuals...
  27. doi Association of a polymorphism of ABCB1 with obesity in Japanese individuals
    Sahoko Ichihara
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514 8507, Japan
    Genomics 91:512-6. 2008
    ..Our results suggest that the ABCB1 genotype may prove informative for assessment of genetic risk for obesity in Japanese individuals...
  28. doi Relationships between mitochondrial DNA subhaplogroups and intracellular calcium dynamics
    An a Kazuno
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Hirosawa 2 1, Wako, Saitama, Japan
    Mitochondrion 8:164-9. 2008
    ..The cybrid having higher calcium levels was subhaplogroup D4a, characterised by a non-synonymous polymorphism, 13651A>G. These mtDNA subhaplogroups might have functional effects...
  29. ncbi Association of polymorphisms of ABCA1 and ROS1 with hypertension in Japanese individuals
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Mie 514 8507, Japan
    Int J Mol Med 21:83-9. 2008
    ..Determination of genotypes for ABCA1 and ROS1 may thus prove informative for the prediction of the genetic risk for hypertension...
  30. ncbi Enrichment of longevity phenotype in mtDNA haplogroups D4b2b, D4a, and D5 in the Japanese population
    Gabriela Alexe
    The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Hum Genet 121:347-56. 2007
    ..Using a simple procedure, we estimated that this event occurred 24.4 +/- 0.9 kYBP...
  31. doi Genetic factors for ischemic and hemorrhagic stroke in Japanese individuals
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Tsu, Mie 514 8507, Japan
    Stroke 39:2211-8. 2008
    ..We performed an association study to identify gene polymorphisms that confer susceptibility to atherothrombotic cerebral infarction, intracerebral hemorrhage, or subarachnoid hemorrhage...
  32. ncbi [Prediction of genetic risk for hypertension]
    Hideo Izawa
    J Cardiol 43:92-3. 2004
    ..Large-scale association studies that examine many gene polymorphisms simultaneously are required to predict genetic risk for hypertension. METHODS and..
  33. ncbi [Haplotype analysis of single nucleotide polymorphisms of mitochondrial DNA]
    Gotaro Watanabe
    Forensic Science Laboratory, Yamagata Prefectural Police Headquarters, Yamagata, Japan
    Nihon Hoigaku Zasshi 58:141-8. 2004
    ..These results show the usefulness of mtDNA haplotype analysis by the presented method for personal identification...
  34. ncbi No association of the mitochondrial genotype (Mt5178A/C) with six cancers in a Japanese population
    Nobuko Iwao
    Health Promotion Research Center, School of Medicine, Aichi Medical University, Aichi, Japan
    Asian Pac J Cancer Prev 4:331-6. 2003
    ..In the present study, the mt5178 genotype seems to have no association with any of the cancers examined here. But an interaction term between the mt5178 genotype and aging on cancer was suggested with the Japanese population under study...
  35. ncbi [Mitochondrial DNA polymorphisms associated with longevity]
    Masashi Tanaka
    Nihon Ronen Igakkai Zasshi 41:384-6. 2004
  36. ncbi A combination of three common inherited mitochondrial DNA polymorphisms promotes longevity in Finnish and Japanese subjects
    Anna Kaisa Niemi
    Department of Neurology, University of Oulu, FIN 90014 Oulu, Finland
    Eur J Hum Genet 13:166-70. 2005
    ..These findings suggest that longevity is partly determined by epistatic interactions involving these three mtDNA loci...
  37. ncbi Association of the mitochondrial DNA 15497G/A polymorphism with obesity in a middle-aged and elderly Japanese population
    Tomohiro Okura
    Department of Epidemiology, National Institute for Longevity Sciences, 36 3 Gengo Morioka cho, Obu shi, 474 8522, Aichi, Japan
    Hum Genet 113:432-6. 2003
    ..062-0.087) in subjects with the A allele compared with the G allele. These data suggest that the Mt15497 polymorphism may be associated with obesity-related variables and lipid metabolism...
  38. ncbi Prediction of genetic risk for hypertension
    Hideo Izawa
    Cardiovascular Division, Department of Pathophysiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Hypertension 41:1035-40. 2003
    ....
  39. ncbi Multiplex amplified product-length polymorphism analysis of 36 mitochondrial single-nucleotide polymorphisms for haplogrouping of East Asian populations
    Kazuo Umetsu
    Department of Experimental and Forensic Pathology, Faculty of Medicine, Yamagata University, Yamagata, Japan
    Electrophoresis 26:91-8. 2005
    ..This is the first panel of mtSNPs in the coding region to be used for haplogrouping of East Asian populations...
  40. ncbi Mitochondrial ATPase subunit 6 and cytochrome B gene polymorphisms in young obese adults
    Noriyuki Fuku
    Department of Sports Medicine, Research Center of Health, Physical Fitness and Sports, Nagoya University, Furo cho, Chikusa ku, Nagoya, 464 8601, Japan
    Biochem Biophys Res Commun 290:1199-205. 2002
    ..The present study indicates that amino acid sequences are less variable for Cytb than for ATP6 in spite of the strong mutational strand asymmetry for the Cytb gene...
  41. ncbi Association of a 5178C-->A (Leu237Met) polymorphism in the mitochondrial DNA with a low prevalence of myocardial infarction in Japanese individuals
    Katsumasa Takagi
    Department of Cardiology, Ogaki Municipal Hospital, Japan
    Atherosclerosis 175:281-6. 2004
    ..These results suggest that the 5178A genotype of mitochondrial ND2 gene polymorphism is protective against MI; and this effect would explain, at least in part, its contribution to longevity...
  42. ncbi Therapeutic potential of pyruvate therapy for mitochondrial diseases
    Masashi Tanaka
    Mitochondrion 7:399-401. 2007
  43. ncbi [Present status of regulation on security concerning medical radioactive sources in Japan]
    Ichiro Yamaguchi
    Nihon Hoshasen Gijutsu Gakkai Zasshi 63:232-6. 2007
  44. ncbi Crystallization and X-ray analysis of the N-terminal core domain of a tumour-associated human DEAD-box RNA helicase, rck/p54
    Tsutomu Matsui
    Department of Life Science, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama 226 8501, Japan
    Acta Crystallogr D Biol Crystallogr 60:156-9. 2004
    ..The crystal belongs to the orthorhombic space group P2(1)2(1)2(1), with unit-cell parameters a = 65.5, b = 73.1, c = 84.8 A, and diffracts X-rays to beyond 2.0 A resolution...
  45. ncbi Progression of alloresponse and tissue-specific immunity during graft coronary artery disease
    Masashi Tanaka
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305 5407, USA
    Am J Transplant 5:1286-96. 2005
    ..Our data suggest that both allo- and tissue-specific immunity might contribute to the induction of GCAD. They indicate that continual autoimmune response against graft tissue antigens may provide for GCAD sustenance...
  46. ncbi An inhibitor of mitochondrial complex I, rotenone, inactivates proteasome by oxidative modification and induces aggregation of oxidized proteins in SH-SY5Y cells
    Masayo Shamoto-Nagai
    Department of Basic Gerontology, National Institute for Longevity Sciences, Obu, Aichi, Japan
    J Neurosci Res 74:589-97. 2003
    ..This mechanism might account for the accumulation of modified protein and, at least partially, for cell death of the dopamine neurons in Parkinson's disease...
  47. pmc Establishment of a new method for precisely determining the functions of individual mitochondrial genes, using Dictyostelium cells
    Junji Chida
    Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Aoba, Sendai 980 8578, Japan
    BMC Genet 9:25. 2008
    ..This is the reason why we tried to establish a novel method for disrupting a certain mitochondrial gene (rps4), using Dictyostelium cells...
  48. ncbi [Electron transfer flavoprotein in mitochondria]
    Kinji Ohno
    Department of Neurology, Mayo Clinic, USA
    Nihon Rinsho 60:113-7. 2002
  49. ncbi Stimulation of paracrine pathways with growth factors enhances embryonic stem cell engraftment and host-specific differentiation in the heart after ischemic myocardial injury
    Theo Kofidis
    Department of Cardiothoracic Surgery, Falk Research Center, Stanford University Medical School, Stanford, Calif 94305, USA
    Circulation 111:2486-93. 2005
    ..We examine the potential of growth factors to enhance cell engraftment and differentiation and to promote functional improvement after transfer of undifferentiated embryonic stem cells into the injured heart...
  50. ncbi Cardiomyocyte-specific Bcl-2 overexpression attenuates ischemia-reperfusion injury, immune response during acute rejection, and graft coronary artery disease
    Masashi Tanaka
    Department of Cardiothoracic Surgery, Falk Cardiovascular Research Center, 300 Pasteur Dr CVRB, Stanford University School of Medicine, Stanford, CA 94305 5407, USA
    Blood 104:3789-96. 2004
    ..In conclusion, our findings suggest that the modulation of Bcl-2 expression by pharmacologic up-regulation or gene transfer may be of clinical benefit in the short- and long-term function of cardiac allografts...
  51. ncbi Early inhibition of caspase-3 activity lessens the development of graft coronary artery disease
    Leora B Balsam
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
    J Heart Lung Transplant 24:827-32. 2005
    ..We hypothesized that early inhibition of apoptosis with a caspase-3 inhibitor would also lessen the development of GCAD...
  52. ncbi Cyclosporine mitigates graft coronary artery disease in murine cardiac allografts: description and validation of a novel fully allogeneic model
    Masashi Tanaka
    Department of Cardiothoracic Surgery, Stanford University Medical Center, Stanford, California 94305, USA
    J Heart Lung Transplant 24:446-53. 2005
    ..We developed a novel allogeneic mouse model of heart transplantation and investigated the effect of CsA on acute rejection and GCAD...
  53. ncbi Dimethylarginine dimethylaminohydrolase overexpression suppresses graft coronary artery disease
    Masashi Tanaka
    Department of Cardiothoracic Surgery, Stanford University Medical Center, Stanford, CA, USA
    Circulation 112:1549-56. 2005
    ..We hypothesized that lowering ADMA concentrations by dimethylarginine dimethylaminohydrolase (DDAH) overexpression in the recipient might suppress GCAD and long-term immune responses in murine cardiac allografts...
  54. ncbi In vivo visualization of cardiac allograft rejection and trafficking passenger leukocytes using bioluminescence imaging
    Masashi Tanaka
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305 5407, USA
    Circulation 112:I105-10. 2005
    ..We investigated the feasibility of bioluminescence imaging (BLI) for the in vivo assessment of cardiac allograft viability and visualization of passenger leukocytes during the course of acute rejection...
  55. ncbi Co-existing point mutations of mitochondrial DNA in a patient with a heart abnormality and Pearson syndrome-like symptoms
    Kae Munakata
    Am J Med Genet A 139:162-4. 2005
  56. ncbi Insulin-like growth factor promotes engraftment, differentiation, and functional improvement after transfer of embryonic stem cells for myocardial restoration
    Theo Kofidis
    Cardiothoracic Surgery, Falk Research Center, Stanford University Medical School, Stanford, CA 94305, USA
    Stem Cells 22:1239-45. 2004
    ..01). IGF did not affect the cellular response to the donor cells or tumorigenicity. IGF-1 promotes expression of cardiomyocyte phenotype in ESCs in vivo. It should be considered as an adjuvant to cell transfer for myocardial restoration...
  57. ncbi A phase II study of weekly paclitaxel combined with carboplatin for elderly patients with advanced non-small cell lung cancer
    Akira Inoue
    Department of Respiratory Oncology and Molecular Medicine, Institute of Development, Aging, and Cancer, Tohoku University, 4 1 Seiryomachi, Aoba ku, Sendai 980 8575, Japan
    Lung Cancer 52:83-7. 2006
    ..A randomized trial comparing this treatment with the conventional tri-weekly regimen of paclitaxel and carboplatin is warranted...
  58. ncbi Mitochondrial DNA 3644T-->C mutation associated with bipolar disorder
    Kae Munakata
    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Hirosawa 2 1, Wako, Saitama 351 0198, Japan
    Genomics 84:1041-50. 2004
    ..The result of modest functional impairment caused by 3644T-->C suggests that this mutation could increase the risk for bipolar disorder...
  59. ncbi Meeting report: mitochondrial DNA and cancer epidemiology
    Mukesh Verma
    Analytic Epidemiology Research Branch, National Cancer Institute, Rockville, Maryland 20852, USA
    Cancer Res 67:437-9. 2007
  60. pmc Preserving genome integrity: the DdrA protein of Deinococcus radiodurans R1
    Dennis R Harris
    Department of Biochemistry, University of Wisconsin, Madison, USA
    PLoS Biol 2:e304. 2004
    ..We propose that DR0423 is part of a DNA end-protection system that helps to preserve genome integrity following exposure to ionizing radiation. We designate the DR0423 protein as DNA damage response A protein...
  61. doi Histone deacetylase inhibitors enhance the chemosensitivity of tumor cells with cross-resistance to a wide range of DNA-damaging drugs
    Kei Ichi Ozaki
    Laboratory of Cell Regulation, Department of Pharmaceutical Sciences, Graduate School of Biomedical Sciences, Nagasaki University, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Cancer Sci 99:376-84. 2008
    ....