Yukio Okano

Summary

Affiliation: Gifu University
Country: Japan

Publications

  1. ncbi request reprint Synergistic induction of apoptosis by acyclic retinoid and interferon-beta in human hepatocellular carcinoma cells
    Akihiro Obora
    First Department of Internal Medicine and Department of Pathobiochemistry, Gifu University School of Medicine, Japan
    Hepatology 36:1115-24. 2002
  2. ncbi request reprint Human Misato regulates mitochondrial distribution and morphology
    Masashi Kimura
    Department of Molecular Pathobiochemistry, Division of Disease Control, Gifu University Graduate School of Medicine, Yanagido 1 1, Gifu 501 1194, Japan
    Exp Cell Res 313:1393-404. 2007
  3. ncbi request reprint UVC radiation induces downregulation of EGF receptor via phosphorylation at serine 1046/1047 in human pancreatic cancer cells
    Takahiro Yamauchi
    Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu, Japan
    Radiat Res 176:565-74. 2011
  4. pmc Inhibition of Rho-associated coiled-coil containing protein kinase enhances the activation of epidermal growth factor receptor in pancreatic cancer cells
    Masanori Nakashima
    Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    Mol Cancer 10:79. 2011
  5. pmc Ultraviolet irradiation can induce evasion of colon cancer cells from stimulation of epidermal growth factor
    Seiji Adachi
    Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    J Biol Chem 286:26178-87. 2011
  6. ncbi request reprint Aberrant promoter hypermethylation of the CHFR gene in oral squamous cell carcinomas
    Seiji Baba
    Department of Oral and Maxillofacial Sciences, Graduate School of Medicine, Gifu University, Gifu 501 1194, Japan
    Oncol Rep 22:1173-9. 2009
  7. doi request reprint Plk1 is negatively regulated by RNF8
    Takashi Yoshioka
    Department of Molecular Pathobiochemistry, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Biochem Biophys Res Commun 410:57-61. 2011
  8. ncbi request reprint Phosphorylated retinoid X receptor alpha loses its heterodimeric activity with retinoic acid receptor beta
    Kotaro Yoshimura
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu, 501 1194, Japan
    Cancer Sci 98:1868-74. 2007
  9. doi request reprint Suppression by heat shock protein 20 of hepatocellular carcinoma cell proliferation via inhibition of the mitogen-activated protein kinases and AKT pathways
    Rie Matsushima-Nishiwaki
    Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    J Cell Biochem 112:3430-9. 2011
  10. doi request reprint EWS-Fli1 up-regulates expression of the Aurora A and Aurora B kinases
    Kazuhiko Wakahara
    Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu, Japan
    Mol Cancer Res 6:1937-45. 2008

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Synergistic induction of apoptosis by acyclic retinoid and interferon-beta in human hepatocellular carcinoma cells
    Akihiro Obora
    First Department of Internal Medicine and Department of Pathobiochemistry, Gifu University School of Medicine, Japan
    Hepatology 36:1115-24. 2002
    ..In conclusion, these results provide a rationale for combined biochemoprevention of HCC using acyclic retinoid and IFN-beta...
  2. ncbi request reprint Human Misato regulates mitochondrial distribution and morphology
    Masashi Kimura
    Department of Molecular Pathobiochemistry, Division of Disease Control, Gifu University Graduate School of Medicine, Yanagido 1 1, Gifu 501 1194, Japan
    Exp Cell Res 313:1393-404. 2007
    ..These results indicated that human Misato has a role(s) in mitochondrial distribution and morphology and that its unregulated expression leads to cell death...
  3. ncbi request reprint UVC radiation induces downregulation of EGF receptor via phosphorylation at serine 1046/1047 in human pancreatic cancer cells
    Takahiro Yamauchi
    Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu, Japan
    Radiat Res 176:565-74. 2011
    ..Taken together, our results suggest that in pancreatic cancer cells UVC radiation induced desensitization of the cells to EGFR stimuli via phosphorylation of EGFR at S1046/7 by activation of p38 MAPK, independent of c-Cbl...
  4. pmc Inhibition of Rho-associated coiled-coil containing protein kinase enhances the activation of epidermal growth factor receptor in pancreatic cancer cells
    Masanori Nakashima
    Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    Mol Cancer 10:79. 2011
    ..In the present study, we investigated the role of ROCK in EGF receptor (EGFR) signaling in the pancreatic cancer cell lines, Panc1, KP3 and AsPc1...
  5. pmc Ultraviolet irradiation can induce evasion of colon cancer cells from stimulation of epidermal growth factor
    Seiji Adachi
    Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    J Biol Chem 286:26178-87. 2011
    ..Hence, UV-C might be applied for clinical strategy against human colon cancers...
  6. ncbi request reprint Aberrant promoter hypermethylation of the CHFR gene in oral squamous cell carcinomas
    Seiji Baba
    Department of Oral and Maxillofacial Sciences, Graduate School of Medicine, Gifu University, Gifu 501 1194, Japan
    Oncol Rep 22:1173-9. 2009
    ..Although further study is needed, Aurora-A gene expression seems to be independent from methylation status of the CHFR gene in OSCC...
  7. doi request reprint Plk1 is negatively regulated by RNF8
    Takashi Yoshioka
    Department of Molecular Pathobiochemistry, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Biochem Biophys Res Commun 410:57-61. 2011
    ..Conversely, Plk1 in normal cell lines was lower than in cancer cell lines. These results suggest that RNF8 is downregulated in many cancer cells and inversely correlated with Plk1...
  8. ncbi request reprint Phosphorylated retinoid X receptor alpha loses its heterodimeric activity with retinoic acid receptor beta
    Kotaro Yoshimura
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu, 501 1194, Japan
    Cancer Sci 98:1868-74. 2007
    ..In conclusion, the inhibition of RXRalpha phosphorylation and the restoration of its original function as a master regulator of nuclear receptors might therefore be an effective strategy for controlling cancer cell growth...
  9. doi request reprint Suppression by heat shock protein 20 of hepatocellular carcinoma cell proliferation via inhibition of the mitogen-activated protein kinases and AKT pathways
    Rie Matsushima-Nishiwaki
    Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    J Cell Biochem 112:3430-9. 2011
    ..Taken together, our findings strongly suggest that HSP20 suppresses the growth of HCC cells via the MAPKs and AKT signaling pathways, thus suggesting that the HSP20 could be a new therapeutic target for HCC...
  10. doi request reprint EWS-Fli1 up-regulates expression of the Aurora A and Aurora B kinases
    Kazuhiko Wakahara
    Department of Orthopaedic Surgery, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu, Japan
    Mol Cancer Res 6:1937-45. 2008
    ..These results strongly suggest that the mitotic kinases Aurora A and Aurora B are regulated by EWS-Fli1 fusion protein in Ewing sarcoma cells...
  11. doi request reprint Evolutionary features and intracellular behavior of the PRTB protein
    Miki Matsunami
    Department of Molecular Pathobiochemistry, Gifu University Graduate School of Medicine, Yanagido, Gifu, Japan
    Biochem Genet 49:458-73. 2011
    ..Together, these results suggest that Lys residues might play important roles in regulating the intracellular dynamics of the PRTB protein...
  12. ncbi request reprint Retinoids in liver fibrosis and cancer
    Masataka Okuno
    First Department of the Internal Medicine, Gifu University School of Medicine, Gifu, Japan
    Front Biosci 7:d204-18. 2002
    ..We propose the concept of "clonal deletion" therapy for cancer chemoprevention, a new category of cancer chemotherapy...
  13. ncbi request reprint An evolutionarily conserved leucine-rich repeat protein CLERC is a centrosomal protein required for spindle pole integrity
    Yoshinori Muto
    Department of Functional Bioscience, Gifu University School of Medicine, Gifu, Japan
    Cell Cycle 7:2738-48. 2008
    ..These data indicate that the major function of CLERC during mitosis is to maintain the structural integrity of centrosomes, thereby contributing to spindle bipolarity...
  14. ncbi request reprint Expression of mitotic Aurora/Ipl1p-related kinases in renal cell carcinomas: an immunohistochemical study
    Hidetoshi Ehara
    Department of Urology, Gifu University School of Medicine, 40 Tsukasa, Gifu 500 8705, Japan
    Urol Res 31:382-6. 2003
    ..Although the precise physiological functions of these kinases are not known, AIRK subfamily expression may play a role in renal cell carcinoma tumorigenesis...
  15. ncbi request reprint [Aurora kinases and cancer]
    Masashi Kimura
    Dept of Molecular Pathobiochemistry, Division of Disease Control, Gifu University Graduate School of Medicine, Japan
    Gan To Kagaku Ryoho 32:1-5. 2005
    ..Ectopic overexpression of Aurora-A or -B protein leads to aneuploid cells. The cells overexpressing active Aurora A or wildtype Aurora-B are tumorigenic in nude mice...
  16. ncbi request reprint Cell cycle-dependent regulation of the human aurora B promoter
    Masashi Kimura
    Department of Molecular Pathobiochemistry, Gifu University School of Medicine, Tsukasamachi 40, Gifu 500 8705, Japan
    Biochem Biophys Res Commun 316:930-6. 2004
    ..These results demonstrate that aurora B mRNA level is regulated by CDE-CHR and that a subset of E2F/DP family proteins binds to the CDE...
  17. pmc Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation
    Satoshi Nemoto
    Department of Cell Signaling, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    J Biol Chem 284:10422-32. 2009
    ..These findings indicate that SPHK isoforms and neutral sphingomyelinase contribute to the regulation of chemosensitivity by controlling ceramide formation and the downstream Akt pathway in human colon cancer cells...
  18. doi request reprint Rho-kinase inhibitor upregulates migration by altering focal adhesion formation via the Akt pathway in colon cancer cells
    Seiji Adachi
    Department of Gastroenterology, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    Eur J Pharmacol 650:145-50. 2011
    ..Taken together, these results strongly suggest that Rho-kinase negatively regulates the migration of colon cancer cells by altering focal adhesion formation via the Akt pathway...
  19. ncbi request reprint Depolarization-induced differentiation of PC12 cells is mediated by phospholipase D2 through the transcription factor CREB pathway
    Yoshiko Banno
    Department of Cell Signaling, Gifu University Graduate School of Medicine, Gifu, Japan
    J Neurochem 104:1372-86. 2008
    ..This is the first demonstration that PLD2 activation is involved in GAP-43 and synapsin I expression during depolarization-induced neuronal differentiation in PC12 cells...
  20. ncbi request reprint Phosphorylation of retinoid X receptor suppresses its ubiquitination in human hepatocellular carcinoma
    Seiji Adachi
    Department of Molecular Pathobiochemistry, Gifu University School of Medicine, Gifu, Japan
    Hepatology 35:332-40. 2002
    ..In conclusion, switching of the ubiquitin/proteasome-dependent degradation of RXRalpha by phosphorylation at serine 260 may be responsible for the aberrant growth of HCC and its suppression by retinoids...
  21. ncbi request reprint The RING finger protein, RNF8, interacts with retinoid X receptor alpha and enhances its transcription-stimulating activity
    Yukihiko Takano
    Department of Molecular Pathobiochemistry, Gifu University School of Medicine, Gifu 500 8705, Japan
    J Biol Chem 279:18926-34. 2004
    ..These results suggest a novel function of RNF8 as a regulator of RXR alpha-mediated transcriptional activity through interaction between their respective N-terminal regions...
  22. ncbi request reprint Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells
    Kaori Sasai
    Department of Molecular Pathology, Division of Pathology and Laboratory Medicine, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cell Motil Cytoskeleton 59:249-63. 2004
    ..Finally, Aurora-C could rescue the Aurora-B silenced multinucleation phenotype, demonstrating that Aurora-C kinase function overlaps with and complements Aurora-B kinase function in mitosis...
  23. ncbi request reprint Roles of aurora-A kinase in mitotic entry and G2 checkpoint in mammalian cells
    Tomotoshi Marumoto
    Department of Tumor Genetics and Biology, Kumamoto University School of Medicine, 2 2 1 Honjo, Kumamoto 860 0811, Japan
    Genes Cells 7:1173-82. 2002
    ..However, the regulation of aurora-A activation and the commitment of aurora-A in the progression of G2-M phase are largely unknown in mammalian cells...
  24. ncbi request reprint Polo-like kinase 1 (PLK1) is overexpressed in primary colorectal cancers
    Takao Takahashi
    Second Department of Surgery, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu 500 8705
    Cancer Sci 94:148-52. 2003
    ..Our results suggest overexpression of PLK1 might be of pathogenic, prognostic and proliferative importance, so that this kinase might have potential as a new tumor marker for colorectal cancers...
  25. pmc Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases
    Claudia Crosio
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, 67404 Illkirch Strasbourg, France
    Mol Cell Biol 22:874-85. 2002
    ..Since Aurora-A and Aurora-B are known to be overexpressed in a variety of human cancers, our findings provide an attractive link between cell transformation, chromatin modifications and a specific kinase system...
  26. ncbi request reprint The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation
    Vanessa Plans
    Institut de Biologia Molecular de Barcelona, CSIC, Jordi Girona 18 26, 08034 Barcelona, Spain
    J Cell Biochem 97:572-82. 2006
    ..Thus, our screening reveals new potential regulators of non-canonical polyubiquitylation...
  27. ncbi request reprint Development of a high-level expression system for deuterium-labeled human serum albumin
    Mihoko Tomida
    Department of Biochemistry, Gifu University School of Medicine, Gifu, 500 8705 Japan
    Jpn J Physiol 53:65-9. 2003
    ....