Kenji Niwa

Summary

Affiliation: Gifu University
Country: Japan

Publications

  1. ncbi request reprint Preventive effects of Glycyrrhizae radix extract on estrogen-related endometrial carcinogenesis in mice
    K Niwa
    Department of Obstetrics, Gifu University School of Medicine
    Jpn J Cancer Res 90:726-32. 1999
  2. ncbi request reprint Topical vidarabine or 5-fluorouracil treatment against persistent HPV in genital (pre)cancerous lesions
    Kenji Niwa
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu City 500 8705, Japan
    Oncol Rep 10:1437-41. 2003
  3. ncbi request reprint Inhibitory effects of toremifene on N-methyl-N-nitrosourea and estradiol-17beta-induced endometrial carcinogenesis in mice
    Kenji Niwa
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu 500 8705
    Jpn J Cancer Res 93:626-35. 2002
  4. ncbi request reprint Preventive effects of isoflavones, genistein and daidzein, on estradiol-17beta-related endometrial carcinogenesis in mice
    Z Lian
    Department of Obstetrics, Gifu University School of Medicine, Gifu 500 8705, Japan
    Jpn J Cancer Res 92:726-34. 2001
  5. ncbi request reprint Preventive effects of Juzen-taiho-to on N-methyl-N-nitrosourea and estradiol-17beta-induced endometrial carcinogenesis in mice
    K Niwa
    Department of Obstetrics and Gynecology and Department of Pathology, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu City 500 8705, Japan
    Carcinogenesis 22:587-91. 2001
  6. ncbi request reprint Preventive effects of danazol on endometrial carcinogenesis in mice
    K Niwa
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, 40 Tsukasa Machi, 500 8705, Gifu, Japan
    Cancer Lett 158:133-9. 2000
  7. ncbi request reprint Inhibitory effects of Hochu-ekki-to on endometrial carcinogenesis induced by N-methyl-N-nitrosourea and 17beta-estradiol in mice
    Kyoko Onogi
    Department of Obstetrics and Gynecology, Gifu University, School of Medicine, Gifu 501 1194, Japan
    Oncol Rep 16:1343-8. 2006
  8. ncbi request reprint Shimotsu-to is the agent in Juzen-taiho-to responsible for the prevention of endometrial carcinogenesis in mice
    Zenglin Lian
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu City 500 8705, Japan
    Cancer Lett 182:19-26. 2002
  9. ncbi request reprint Preventive effects of glycyrrhizin on estrogen-related endometrial carcinogenesis in mice
    Kenji Niwa
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu 501 1194, Japan
    Oncol Rep 17:617-22. 2007
  10. ncbi request reprint Preventive effect of Juzen-taiho-to on endometrial carcinogenesis in mice is based on Shimotsu-to constituent
    Keiko Tagami
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu 500 8705, Japan
    Biol Pharm Bull 27:156-61. 2004

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Preventive effects of Glycyrrhizae radix extract on estrogen-related endometrial carcinogenesis in mice
    K Niwa
    Department of Obstetrics, Gifu University School of Medicine
    Jpn J Cancer Res 90:726-32. 1999
    ..It is suggested that Gl radix has inhibitory effects on E2-related endometrial carcinogenesis in mice, through suppression of estrogen-induced c-fos/jun-expressions...
  2. ncbi request reprint Topical vidarabine or 5-fluorouracil treatment against persistent HPV in genital (pre)cancerous lesions
    Kenji Niwa
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu City 500 8705, Japan
    Oncol Rep 10:1437-41. 2003
    ..Topical vidarabine or 5-FU treatment is beneficial for HPV-positive cases after local surgical excision...
  3. ncbi request reprint Inhibitory effects of toremifene on N-methyl-N-nitrosourea and estradiol-17beta-induced endometrial carcinogenesis in mice
    Kenji Niwa
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu 500 8705
    Jpn J Cancer Res 93:626-35. 2002
    ..Such suppressive effects of TOR may be related to the decreased ER-alpha and increased ER-beta expressions...
  4. ncbi request reprint Preventive effects of isoflavones, genistein and daidzein, on estradiol-17beta-related endometrial carcinogenesis in mice
    Z Lian
    Department of Obstetrics, Gifu University School of Medicine, Gifu 500 8705, Japan
    Jpn J Cancer Res 92:726-34. 2001
    ....
  5. ncbi request reprint Preventive effects of Juzen-taiho-to on N-methyl-N-nitrosourea and estradiol-17beta-induced endometrial carcinogenesis in mice
    K Niwa
    Department of Obstetrics and Gynecology and Department of Pathology, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu City 500 8705, Japan
    Carcinogenesis 22:587-91. 2001
    ..01), under estrogenic stimulation. It is suggested that Juzen-taiho-to has an inhibitory effect on E2-related endometrial carcinogenesis in mice, relevantly through suppression of estrogen-induced c-fos/jun-expression...
  6. ncbi request reprint Preventive effects of danazol on endometrial carcinogenesis in mice
    K Niwa
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, 40 Tsukasa Machi, 500 8705, Gifu, Japan
    Cancer Lett 158:133-9. 2000
    ..These results suggest that danazol has preventive effects on estrogen-related endometrial carcinogenesis in mice, through the suppression of estrogen-induced c-fos/jun-expression...
  7. ncbi request reprint Inhibitory effects of Hochu-ekki-to on endometrial carcinogenesis induced by N-methyl-N-nitrosourea and 17beta-estradiol in mice
    Kyoko Onogi
    Department of Obstetrics and Gynecology, Gifu University, School of Medicine, Gifu 501 1194, Japan
    Oncol Rep 16:1343-8. 2006
    ..The inhibitory effect of Hochu-ekki-to on endometrial carcinogenesis is thus suggested to decrease the expressions of c-jun, TNF-alpha, ER-alpha and -beta...
  8. ncbi request reprint Shimotsu-to is the agent in Juzen-taiho-to responsible for the prevention of endometrial carcinogenesis in mice
    Zenglin Lian
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu City 500 8705, Japan
    Cancer Lett 182:19-26. 2002
    ..01). A similar trend was not found upon treatment with Shikunshi-to. These findings suggest that Shimotsu-to is responsible for the inhibitory effects of Juzen-taiho-to on the estrogen-related endometrial carcinogenesis in mice...
  9. ncbi request reprint Preventive effects of glycyrrhizin on estrogen-related endometrial carcinogenesis in mice
    Kenji Niwa
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu 501 1194, Japan
    Oncol Rep 17:617-22. 2007
    ..Gl radix and GL could therefore be a promising formula for the chemoprevention of human endometrial cancer...
  10. ncbi request reprint Preventive effect of Juzen-taiho-to on endometrial carcinogenesis in mice is based on Shimotsu-to constituent
    Keiko Tagami
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu 500 8705, Japan
    Biol Pharm Bull 27:156-61. 2004
    ....
  11. ncbi request reprint Significant anti-proliferation of human endometrial cancer cells by combined treatment with a selective COX-2 inhibitor NS398 and specific MEK inhibitor U0126
    Jingchun Gao
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu City 501 1194, Japan
    Int J Oncol 26:737-44. 2005
    ....
  12. ncbi request reprint Anti-tumor effects of herbal medicines on endometrial carcinomas via estrogen receptor-alpha-related mechanism
    Zenglin Lian
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, Yanagido, Gifu City 501 1194, Japan
    Oncol Rep 15:1133-6. 2006
    ..The anti-tumor effect of these herbal medicines against endometrial carcinoma might be correlated to the ER-alpha related mechanism...
  13. ncbi request reprint Association of cellular apoptosis with anti-tumor effects of the Chinese herbal complex in endocrine-resistant cancer cell line
    Zenglin Lian
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu City, 500 8705, Japan
    Cancer Detect Prev 27:147-54. 2003
    ..Thus, it is suggested that the special herbal complex may be a promising candidate for the treatment of endocrine-resistant gynecologic carcinomas...
  14. ncbi request reprint PTEN sensitizes epidermal growth factor-mediated proliferation in endometrial carcinoma cells
    Liu Lin Tang
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu 501 1194, Japan
    Oncol Rep 15:855-9. 2006
    ..These results imply that the dysfunction of PTEN leads cells into a less-sensitive phenotype to peptide growth factors by constitutive activation of the PI3K/Akt/PKB signaling pathway in endometrial carcinoma...
  15. ncbi request reprint Non-steroidal anti-inflammatory drugs inhibit cellular proliferation and upregulate cyclooxygenase-2 protein expression in endometrial cancer cells
    Jingchun Gao
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu 501 1194
    Cancer Sci 95:901-7. 2004
    ..A cytochrome c-dependent apoptotic pathway and/or cell cycle arrest may contribute to the inhibitory effects of these NSAIDs...
  16. ncbi request reprint Cervical large cell neuroendocrine carcinoma with cytologic presentation: a case report
    Kenji Niwa
    Department of Obstetrics and Gynecology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu City, Gifu 501 1194, Japan
    Acta Cytol 54:977-80. 2010
    ..Large cell neuroendocrine carcinoma (LCNEC) is a rare and aggressive cervical neoplasm. Few cytologic or colposcopic findings of LCNEC have been reported...
  17. ncbi request reprint Prognostic implications of cimetidine on advanced serous ovarian carcinoma related to cyclooxygenase-2 expression
    Kenji Niwa
    Department of Obstetrics and Gynecology, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    Mol Med Report 1:119-22. 2008
    ..Platinum-based chemotherapy combined with cimetidine, as a first-line therapy, may improve the prognosis of patients with advanced serous ovarian carcinoma...
  18. ncbi request reprint Randomized phase III trial of pelvic radiotherapy versus cisplatin-based combined chemotherapy in patients with intermediate- and high-risk endometrial cancer: a Japanese Gynecologic Oncology Group study
    Nobuyuki Susumu
    School of Medicine, Keio University, Shinjyuku ku, Tokyo, Japan
    Gynecol Oncol 108:226-33. 2008
    ....