Kenji Niwa

Summary

Affiliation: Gifu University
Country: Japan

Publications

  1. ncbi Preventive effects of Glycyrrhizae radix extract on estrogen-related endometrial carcinogenesis in mice
    K Niwa
    Department of Obstetrics, Gifu University School of Medicine
    Jpn J Cancer Res 90:726-32. 1999
  2. ncbi Topical vidarabine or 5-fluorouracil treatment against persistent HPV in genital (pre)cancerous lesions
    Kenji Niwa
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu City 500 8705, Japan
    Oncol Rep 10:1437-41. 2003
  3. ncbi Inhibitory effects of toremifene on N-methyl-N-nitrosourea and estradiol-17beta-induced endometrial carcinogenesis in mice
    Kenji Niwa
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu 500 8705
    Jpn J Cancer Res 93:626-35. 2002
  4. ncbi Preventive effects of isoflavones, genistein and daidzein, on estradiol-17beta-related endometrial carcinogenesis in mice
    Z Lian
    Department of Obstetrics, Gifu University School of Medicine, Gifu 500 8705, Japan
    Jpn J Cancer Res 92:726-34. 2001
  5. ncbi Preventive effects of Juzen-taiho-to on N-methyl-N-nitrosourea and estradiol-17beta-induced endometrial carcinogenesis in mice
    K Niwa
    Department of Obstetrics and Gynecology and Department of Pathology, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu City 500 8705, Japan
    Carcinogenesis 22:587-91. 2001
  6. ncbi Preventive effects of danazol on endometrial carcinogenesis in mice
    K Niwa
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, 40 Tsukasa Machi, 500 8705, Gifu, Japan
    Cancer Lett 158:133-9. 2000
  7. ncbi Inhibitory effects of Hochu-ekki-to on endometrial carcinogenesis induced by N-methyl-N-nitrosourea and 17beta-estradiol in mice
    Kyoko Onogi
    Department of Obstetrics and Gynecology, Gifu University, School of Medicine, Gifu 501-1194, Japan
    Oncol Rep 16:1343-8. 2006
  8. ncbi Shimotsu-to is the agent in Juzen-taiho-to responsible for the prevention of endometrial carcinogenesis in mice
    Zenglin Lian
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu-city 500-8705, Japan
    Cancer Lett 182:19-26. 2002
  9. ncbi Preventive effects of glycyrrhizin on estrogen-related endometrial carcinogenesis in mice
    Kenji Niwa
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu 501 1194, Japan
    Oncol Rep 17:617-22. 2007
  10. ncbi Preventive effect of Juzen-taiho-to on endometrial carcinogenesis in mice is based on Shimotsu-to constituent
    Keiko Tagami
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu 500-8705, Japan
    Biol Pharm Bull 27:156-61. 2004

Collaborators

Detail Information

Publications18

  1. ncbi Preventive effects of Glycyrrhizae radix extract on estrogen-related endometrial carcinogenesis in mice
    K Niwa
    Department of Obstetrics, Gifu University School of Medicine
    Jpn J Cancer Res 90:726-32. 1999
    ..It is suggested that Gl radix has inhibitory effects on E2-related endometrial carcinogenesis in mice, through suppression of estrogen-induced c-fos/jun-expressions...
  2. ncbi Topical vidarabine or 5-fluorouracil treatment against persistent HPV in genital (pre)cancerous lesions
    Kenji Niwa
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu City 500 8705, Japan
    Oncol Rep 10:1437-41. 2003
    ..Topical vidarabine or 5-FU treatment is beneficial for HPV-positive cases after local surgical excision...
  3. ncbi Inhibitory effects of toremifene on N-methyl-N-nitrosourea and estradiol-17beta-induced endometrial carcinogenesis in mice
    Kenji Niwa
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu 500 8705
    Jpn J Cancer Res 93:626-35. 2002
    ..Such suppressive effects of TOR may be related to the decreased ER-alpha and increased ER-beta expressions...
  4. ncbi Preventive effects of isoflavones, genistein and daidzein, on estradiol-17beta-related endometrial carcinogenesis in mice
    Z Lian
    Department of Obstetrics, Gifu University School of Medicine, Gifu 500 8705, Japan
    Jpn J Cancer Res 92:726-34. 2001
    ....
  5. ncbi Preventive effects of Juzen-taiho-to on N-methyl-N-nitrosourea and estradiol-17beta-induced endometrial carcinogenesis in mice
    K Niwa
    Department of Obstetrics and Gynecology and Department of Pathology, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu City 500 8705, Japan
    Carcinogenesis 22:587-91. 2001
    ..01), under estrogenic stimulation. It is suggested that Juzen-taiho-to has an inhibitory effect on E2-related endometrial carcinogenesis in mice, relevantly through suppression of estrogen-induced c-fos/jun-expression...
  6. ncbi Preventive effects of danazol on endometrial carcinogenesis in mice
    K Niwa
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, 40 Tsukasa Machi, 500 8705, Gifu, Japan
    Cancer Lett 158:133-9. 2000
    ..These results suggest that danazol has preventive effects on estrogen-related endometrial carcinogenesis in mice, through the suppression of estrogen-induced c-fos/jun-expression...
  7. ncbi Inhibitory effects of Hochu-ekki-to on endometrial carcinogenesis induced by N-methyl-N-nitrosourea and 17beta-estradiol in mice
    Kyoko Onogi
    Department of Obstetrics and Gynecology, Gifu University, School of Medicine, Gifu 501-1194, Japan
    Oncol Rep 16:1343-8. 2006
    ..The inhibitory effect of Hochu-ekki-to on endometrial carcinogenesis is thus suggested to decrease the expressions of c-jun, TNF-alpha, ER-alpha and -beta...
  8. ncbi Shimotsu-to is the agent in Juzen-taiho-to responsible for the prevention of endometrial carcinogenesis in mice
    Zenglin Lian
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu-city 500-8705, Japan
    Cancer Lett 182:19-26. 2002
    ..01). A similar trend was not found upon treatment with Shikunshi-to. These findings suggest that Shimotsu-to is responsible for the inhibitory effects of Juzen-taiho-to on the estrogen-related endometrial carcinogenesis in mice...
  9. ncbi Preventive effects of glycyrrhizin on estrogen-related endometrial carcinogenesis in mice
    Kenji Niwa
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu 501 1194, Japan
    Oncol Rep 17:617-22. 2007
    ..Gl radix and GL could therefore be a promising formula for the chemoprevention of human endometrial cancer...
  10. ncbi Preventive effect of Juzen-taiho-to on endometrial carcinogenesis in mice is based on Shimotsu-to constituent
    Keiko Tagami
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu 500-8705, Japan
    Biol Pharm Bull 27:156-61. 2004
    ....
  11. ncbi Significant anti-proliferation of human endometrial cancer cells by combined treatment with a selective COX-2 inhibitor NS398 and specific MEK inhibitor U0126
    Jingchun Gao
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu City 501 1194, Japan
    Int J Oncol 26:737-44. 2005
    ....
  12. ncbi Anti-tumor effects of herbal medicines on endometrial carcinomas via estrogen receptor-alpha-related mechanism
    Zenglin Lian
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, Yanagido, Gifu-city 501-1194, Japan
    Oncol Rep 15:1133-6. 2006
    ..The anti-tumor effect of these herbal medicines against endometrial carcinoma might be correlated to the ER-alpha related mechanism...
  13. ncbi Association of cellular apoptosis with anti-tumor effects of the Chinese herbal complex in endocrine-resistant cancer cell line
    Zenglin Lian
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu City, 500-8705, Japan
    Cancer Detect Prev 27:147-54. 2003
    ..Thus, it is suggested that the special herbal complex may be a promising candidate for the treatment of endocrine-resistant gynecologic carcinomas...
  14. ncbi PTEN sensitizes epidermal growth factor-mediated proliferation in endometrial carcinoma cells
    Liu Lin Tang
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu 501 1194, Japan
    Oncol Rep 15:855-9. 2006
    ..These results imply that the dysfunction of PTEN leads cells into a less-sensitive phenotype to peptide growth factors by constitutive activation of the PI3K/Akt/PKB signaling pathway in endometrial carcinoma...
  15. ncbi Non-steroidal anti-inflammatory drugs inhibit cellular proliferation and upregulate cyclooxygenase-2 protein expression in endometrial cancer cells
    Jingchun Gao
    Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu 501-1194
    Cancer Sci 95:901-7. 2004
    ..A cytochrome c-dependent apoptotic pathway and/or cell cycle arrest may contribute to the inhibitory effects of these NSAIDs...
  16. ncbi Cervical large cell neuroendocrine carcinoma with cytologic presentation: a case report
    Kenji Niwa
    Department of Obstetrics and Gynecology, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu City, Gifu 501 1194, Japan
    Acta Cytol 54:977-80. 2010
    ..Large cell neuroendocrine carcinoma (LCNEC) is a rare and aggressive cervical neoplasm. Few cytologic or colposcopic findings of LCNEC have been reported...
  17. ncbi Prognostic implications of cimetidine on advanced serous ovarian carcinoma related to cyclooxygenase-2 expression
    Kenji Niwa
    Department of Obstetrics and Gynecology, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    Mol Med Report 1:119-22. 2008
    ..Platinum-based chemotherapy combined with cimetidine, as a first-line therapy, may improve the prognosis of patients with advanced serous ovarian carcinoma...
  18. ncbi Randomized phase III trial of pelvic radiotherapy versus cisplatin-based combined chemotherapy in patients with intermediate- and high-risk endometrial cancer: a Japanese Gynecologic Oncology Group study
    Nobuyuki Susumu
    School of Medicine, Keio University, Shinjyuku ku, Tokyo, Japan
    Gynecol Oncol 108:226-33. 2008
    ....